Maxime MAHE

Présentation

Publications

Article dans une revue (32)

Differentiating Enteric Glial Cells Within Intestinal Organoids Derived from Human Pluripotent Stem Cells Simon Vales,Lola Bonneau,Maxime Mahe Methods in Molecular Biology, 2026, Methods in Molecular Biology, 2971, pp.67-80. ⟨10.1007/978-1-0716-4795-0_7⟩ Article dans une revue hal-05538176v1
Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature Charlie J Childs,Holly M Poling,Kevin Chen,Yu-Hwai Tsai,Angeline Wuet al. Cell Stem Cell, 2025, 32 (4), pp.640 - 651.e9. ⟨10.1016/j.stem.2025.02.007⟩ Article dans une revue hal-05245243v1
Generation of Intestinal and Colonic Organoids Derived From Human Pluripotent Stem Cells Lola Bonneau,Lisa Brossard,Theo Noël,Victor Perreaux,Laura Bachiret al. Biology of the Cell, 2025, 117 (12), pp.e70044. ⟨10.1111/boc.70044⟩ Article dans une revue hal-05535984v1
Unraveling enteroendocrine cell lineage dynamics and associated gene regulatory networks during intestinal development Sara Jiménez,Florence Blot,Aline Meunier,Rishabh Kapoor,Valérie Schreiberet al. Biology Open, 2025, 14 (10), pp.bio062083. ⟨10.1242/bio.062083⟩ Article dans une revue inserm-05324757v2
HUMESS: integrating quantitative transcriptomic analysis and metabolic modeling to unveil condition-specific gene signatures Louis Paré,Philippe Bordron,Laurent David,Maxime Mahé,Audrey Bihouéeet al. Bioinformatics, 2025, 41 (8), pp.btaf448. ⟨10.1093/bioinformatics/btaf448⟩ Article dans une revue hal-05232371v1
Gut-liver interaction study on an all-polydimethylsiloxane microfluidic device integrating intestinal paracellular permeability assay Ryuya Kida,Alan Rajendran,Mamiko Tsugane,Jean-Charles Duclos-Vallée,Maxime M Maheet al. Talanta Open, 2024, 9, pp.100289. ⟨10.1016/j.talo.2024.100289⟩ Article dans une revue hal-04437999v1
Human pluripotent stem cell-derived organoids repair damaged bowel in vivo Holly Poling,Nambirajan Sundaram,Garrett Fisher,Akaljot Singh,Joseph Shileyet al. Cell Stem Cell, 2024, 31 (10), pp.1513-1523.e7. ⟨10.1016/j.stem.2024.08.009⟩ Article dans une revue hal-04753428v1
Community metabolic modeling of host-microbiota interactions through multi-objective optimization Anna Lambert,Marko Budinich,Maxime Mahé,Damien Eveillard,Samuel Chaffron iScience, 2024, 27 (6), ⟨10.1016/j.isci.2024.110092⟩ Article dans une revue hal-04674843v1
Multi-disciplinary Insights from the First European Forum on Visceral Myopathy 2022 Meeting Federica Viti,Roberto de Giorgio,Isabella Ceccherini,Arti Ahluwalia,Maria Alveset al. Digestive Diseases and Sciences, In press, ⟨10.1007/s10620-023-08066-1⟩ Article dans une revue (article de synthèse) hal-04193171v1
Gut microbiota remodeling and intestinal adaptation to lipid malabsorption after enteroendocrine cell loss in adult mice Florence Blot,Justine Marchix,Miriam Ejarque,Sara Jiménez,Aline Meunieret al. Cellular and Molecular Gastroenterology and Hepatology, 2023, ⟨10.1016/j.jcmgh.2023.02.013⟩ Article dans une revue hal-04007457v1
Pour une bonne compréhension et un bon usage du terme « organoïdes » Hervé Chneiweiss,Anne Dubart-Kupperschmitt,Jean-Charles Duclos-Vallée,Bruno Clément,Vincent Flacheret al. Médecine/Sciences, 2023, 39 (11), pp.876-878. ⟨10.1051/medsci/2023155⟩ Article dans une revue hal-04314955v1
In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice Carine Bouffi,Kathryn A Wikenheiser-Brokamp,Praneet Chaturvedi,Nambirajan Sundaram,Gillian R Goddardet al. Nature Biotechnology, 2023, 41 (6), pp.824 - 831. ⟨10.1038/s41587-022-01558-x⟩ Article dans une revue hal-04821020v1
Redesigning hydrogel geometry for enhanced organoids Killian Hillion,Maxime Mahe Nature Methods, 2022, 19 (11), pp.1347-1348. ⟨10.1038/s41592-022-01656-3⟩ Article dans une revue hal-04821213v1
Intestinal Organoids: New Tools to Comprehend the Virulence of Bacterial Foodborne Pathogens Mayra Aguirre Garcia,Killian Hillion,Jean-Michel Cappelier,Michel Neunlist,Maxime Mahéet al. Foods, 2022, 11 (1), pp.108. ⟨10.3390/foods11010108⟩ Article dans une revue (article de synthèse) hal-03635060v1
UNC45A deficiency causes microvillus inclusion disease-like phenotype by impairing myosin VB-dependent apical trafficking Rémi Duclaux-Loras,Corinne Lebreton,Jérémy Berthelet,Fabienne Charbit-Henrion,Ophélie Nicolleet al. Journal of Clinical Investigation, 2022, 132 (10), ⟨10.1172/JCI154997⟩ Article dans une revue hal-03756921v2
PGI 2 Inhibits Intestinal Epithelial Permeability and Apoptosis to Alleviate Colitis Camille Pochard,Jacques Gonzales,Anne Bessard,Maxime Mahé,Arnaud Bourreilleet al. Cellular and Molecular Gastroenterology and Hepatology, 2021, 12 (3), pp.1037-1060. ⟨10.1016/j.jcmgh.2021.05.001⟩ Article dans une revue inserm-03287962v2
Modeling Gastrointestinal Diseases Using Organoids to Understand Healing and Regenerative Processes Alexane Ollivier,Maxime Mahé,Géraldine Guasch Cells, 2021, 10 (6), pp.1331. ⟨10.3390/cells10061331⟩ Article dans une revue hal-03324435v1
Intestinal multicellular organoids to study colorectal cancer Musa Idris,Maria M Alves,Robert M.W. Hofstra,Maxime Mahé,Veerle Melotte Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2021, 1876 (2), pp.188586. ⟨10.1016/j.bbcan.2021.188586⟩ Article dans une revue hal-03324410v1
Intestinal Stem Cell-on-Chip to Study Human Host-Microbiota Interaction Fatina Siwczak,Elise Loffet,Mathilda Kaminska,Hristina Koceva,Maxime Mahéet al. Frontiers in Immunology, 2021, 12, pp.798552. ⟨10.3389/fimmu.2021.798552⟩ Article dans une revue hal-03509981v1
In Vivo Human PSC-Derived Intestinal Organoids to Study Stem Cell Maintenance Simon Vales,Holly M Poling,Nambirajan Sundaram,Michael A Helmrath,Maxime Mahé Methods in Molecular Biology, 2020, 2171, pp.201-214. ⟨10.1007/978-1-0716-0747-3_12⟩ Article dans une revue hal-03619037v1
Secretion of acid sphingomyelinase and ceramide by endothelial cells contributes to radiation induced intestinal toxicity Daniela Leonetti,Hala Estephan,Natacha Ripoche,Nolwenn Dubois,Audrey Aguesseet al. Cancer Research, 2020, ⟨10.1158/0008-5472.CAN-19-1527⟩ Article dans une revue inserm-02539662v1
An Organoid-Based Preclinical Model of Human Gastric Cancer Nina Steele,Jayati Chakrabarti,Jiang Wang,Jacek Biesiada,Loryn Holokaiet al. Cellular and Molecular Gastroenterology and Hepatology, 2019, 7 (1), pp.161-184. ⟨10.1016/j.jcmgh.2018.09.008⟩ Article dans une revue hal-02537887v1
Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on Single-Cell Transcriptome Analyses Sin-Ting Lau,Zhixin Li,Frank Pui-Ling Lai,Kathy Nga-Chu Lui,Peng Liet al. Gastroenterology, 2019, 157 (6), pp.1556-1571.e5. ⟨10.1053/j.gastro.2019.08.019⟩ Article dans une revue hal-02533083v1
Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling Jorge O. Múnera,Nambirajan Sundaram,Scott A. Rankin,David Hill,Carey Watsonet al. Cell Stem Cell, 2019, 24 (5), pp.829. ⟨10.1016/j.stem.2017.05.020⟩ Article dans une revue hal-02533282v1
IL-13–induced intestinal secretory epithelial cell antigen passages are required for IgE-mediated food-induced anaphylaxis Taeko K. Noah,Kathryn A. Knoop,Keely G. Mcdonald,Jenny K. Gustafsson,Lisa Waggoneret al. Journal of Allergy and Clinical Immunology, 2019, 144 (4), pp.1058-1073.e3. ⟨10.1016/j.jaci.2019.04.030⟩ Article dans une revue hal-02533221v1
Façonner l'intestin à partir des cellules souches pluripotentes humaines Charlotte Flatres,Élise Loffet,Michel Neunlist,Maxime Mahé Médecine/Sciences, 2019, 35 (6-7), pp.549-555. ⟨10.1051/medsci/2019096⟩ Article dans une revue hal-02533078v1
Engineering a second brain in a dish Maxime Mahé Brain Research, 2018, 1693, pp.165-168. ⟨10.1016/j.brainres.2018.04.015⟩ Article dans une revue hal-02537921v1
Mechanically induced development and maturation of human intestinal organoids in vivo Holly Poling,David Wu,Nicole Brown,Michael Baker,Taylor Hausfeldet al. Nature Biomedical Engineering, 2018, 2 (6), pp.429 - 442. ⟨10.1038/s41551-018-0243-9⟩ Article dans une revue hal-01816387v1
Transplantation of human intestinal organoids into the mouse mesentery: A more physiologic and anatomic engraftment site Alexander R Cortez,Holly M Poling,Nicole E Brown,Akaljot Singh,Maxime Mahéet al. Surgery, 2018, 164 (4), pp.643-650. ⟨10.1016/j.surg.2018.04.048⟩ Article dans une revue hal-02537905v1
Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system Michael Workman,Maxime Mahe,Stephen Trisno,Holly Poling,Carey Watsonet al. Nature Medicine, 2017, 23 (1), pp.49-59. ⟨10.1038/nm.4233⟩ Article dans une revue hal-04166109v1
The digestive neuronal–glial–epithelial unit: a new actor in gut health and disease Michel Neunlist,Laurianne van Landeghem,Maxime Mahé,Pascal Derkinderen,Stanislas Bruley Des Varanneset al. Nature reviews. Gastroenterology & hepatology, 2012, 10 (2), pp.90-100. ⟨10.1038/nrgastro.2012.221⟩ Article dans une revue hal-04905625v1
Regulation of intestinal epithelial cells transcriptome by enteric glial cells: impact on intestinal epithelial barrier functions. Laurianne van Landeghem,Maxime Mahé,Raluca Teusan,Jean Léger,Isabelle Guisleet al. BMC Genomics, 2009, 10 (1), pp.507. ⟨10.1186/1471-2164-10-507⟩ Article dans une revue inserm-00663570v1

Communication dans un congrès (2)

Monolithic co-culture system for the gut-liver interaction study integrating paracellular barrier function assay Ryuya Kida,Alan Raj Jeffrey Rajendran,Mamiko Tsugane,Jean-Charles Duclos-Vallée,Maxime Mahéet al. MicroTAS, Oct 2023, Katowice, Poland Communication dans un congrès hal-04466148v1
Effets protecteurs combinés de bactéries propioniques laitières et des acides gras polyinsaturés n-6 sur la barrière épithéliale intestinale Mantel Marine,Julie Beaudeau,Maxime Mahé,Fillipe Luiz Rosa Do Carmo,Nassima Illikoudet al. Réunion virtuelle "Glande mammaire lait" / Galactinnov, réseau, Galactinnov, est porté par Pierre Germon (INRA, UMR1282 Infectiologie et Santé Publique-ISP, Nouzilly)., Nov 2021, live, France Communication dans un congrès hal-03435200v1

Poster de conférence (1)

Combined protective effects of dairy propionic bacteria and n-6 polyunsaturated fatty acids on the intestinal epithelial barrier Mantel Marine,Maxime M Mahe,Nassima Illikoud,Nicolas Cenac,Michel Neunlistet al. 17e congrès national de la SFM « La microbiologie dans tous ses états », Oct 2022, Montpellier, France. , 2022 Poster de conférence hal-03817222v1

Chapitre d'ouvrage (2)

In vivo human PSC-derived intestinal organoids to study stem cell maintenance Vales Simon,Poling Holly,Sundaram Nambirajan,Michael A Helmrath,Maxime Mahé Intestinal Stem Cells, Epub ahead of print, In press Chapitre d'ouvrage inserm-02578852v1
Pluripotent stem cell derived intestinal organoids with an enteric nervous system Elise Loffet,Lisa Brossard,Maxime Mahé Human Pluripotent Stem Cell Derived Organoid Models, pp.175-199, 2020, ⟨10.1016/bs.mcb.2020.04.012⟩ Chapitre d'ouvrage hal-03327960v1

Pré-publication, Document de travail (2)

HUMESS: Integrating Quantitative Transcriptomic Analysis and Metabolic Modeling to Unveil Condition-Specific Gene Signatures Louis Paré,Philippe Bordron,Laurent David,Maxime Mahé,Audrey Bihouéeet al. 2025 Pré-publication, Document de travail hal-05044080v1
Community metabolic modeling of host-microbiota interactions through multi-objective optimization Anna Lambert,Marko Budinich,Maxime Mahé,Samuel Chaffron,Damien Eveillard 2023 Pré-publication, Document de travail hal-04316271v1