Michel Boisbrun Maître de Conférences HDR, Université de LorraineEnseignement : Faculté de ParmacieRecherche : Laboratoire Lorraine de Chimie Moléculaire (L2CM), UMR CNRS 7053

Identifiants chercheurs

IdHAL :

michel-boisbrun

ORCID :

0000-0001-6588-0027

IdRef :

087260093

Présentation

Publications

Article dans une revue (34)

Synthesis and Pharmacological Characterization of Fluorescent Ligands Targeting the Angiotensin II Receptors Derived from Agonists, β-Arrestin-Biased Agonists, and Antagonists Céline Delaitre,Michel Boisbrun,Samir Acherar,André Dias,Alexandra Kleinclausset al. Journal of Medicinal Chemistry, 2024, 67 (22), pp.20275-20297. ⟨10.1021/acs.jmedchem.4c01693⟩ Article dans une revue hal-04785925v1
The troglitazone derivative EP13 disrupts energy metabolism through respiratory chain complex I inhibition in breast cancer cells and potentiates the antiproliferative effect of glycolysis inhibitors Claire Muller,Victorine Lacroix-Malgras,Jérôme Kluza,William Laine,Yonca Güleret al. Cancer Cell International, 2024, 24 (1), pp.132. ⟨10.1186/s12935-024-03319-z⟩ Article dans une revue hal-04564424v1
Characterization of Biological Properties of Individual Phenolamides and Phenolamide-Enriched Leaf Tomato Extracts Marwa Roumani,Armelle Ropars,Christophe Robin,Raphaël E Duval,Jean-Pol Frippiatet al. Molecules, 2023, 28 (4), pp.1552. ⟨10.3390/molecules28041552⟩ Article dans une revue hal-03975870v1
Unexplored Vinylic-Substituted 5-Benzylidenethiazolidine-2,4-diones: Synthesis and DFT/NMR Stereochemical Assignment Dorian Dupommier,Michel Boisbrun,Gerald Monard,Corinne Comoy Journal of Organic Chemistry, 2023, 88 (6), pp.3724-3739. ⟨10.1021/acs.joc.2c02996⟩ Article dans une revue hal-04186308v1
AB186 inhibits migration of triple-negative breast cancer cells and interacts with α-tubulin Marine Geoffroy,Marine Lemesle,Alexandra Kleinclauss,Sabine Mazerbourg,Levy Batistaet al. International Journal of Molecular Sciences, 2022, 23 (12), pp.6859. ⟨10.3390/ijms23126859⟩ Article dans une revue hal-04238267v1
Transcriptomics and Metabolomics Analyses Reveal High Induction of the Phenolamide Pathway in Tomato Plants Attacked by the Leafminer Tuta absoluta Marwa Roumani,Jacques Le Bot,Michel Boisbrun,Florent Magot,Arthur Péréet al. Metabolites, 2022, 12 (6), pp.484. ⟨10.3390/metabo12060484⟩ Article dans une revue hal-03681534v1
Photoisomerization of Arylidene Heterocycles: Toward the Formation of Fused Heterocyclic Quinolines Elodie Cortelazzo-Polisini,Michel Boisbrun,Axel Hans Gansmüller,Corinne Comoy Journal of Organic Chemistry, 2022, 87 (15), pp.9699-9713. ⟨10.1021/acs.joc.2c00748⟩ Article dans une revue hal-03826852v1
Targeting the Angiotensin II Type 1 Receptor in Cerebrovascular Diseases: Biased Signaling Raises New Hopes Céline Delaitre,Michel Boisbrun,Sandra Lecat,François Dupuis International Journal of Molecular Sciences, 2021, 22 (13), pp.6738. ⟨10.3390/ijms22136738⟩ Article dans une revue hal-03287839v1
Corrigendum to “New desulfured troglitazone derivatives: Improved synthesis and biological evaluation” [Eur. J. Med. Chem. 187 (2020) 111939] Dorian Dupommier,Claire Muller,Corinne Comoy,Sabine Mazerbourg,Andrea Bordessaet al. European Journal of Medicinal Chemistry, 2020, 208, pp.112834. ⟨10.1016/j.ejmech.2020.112834⟩ Article dans une revue hal-03503731v1
New desulfured troglitazone derivatives: Improved synthesis and biological evaluation Dorian Dupommier,Claire Muller,Corinne Comoy,Sabine Mazerbourg,Andrea Bordessaet al. European Journal of Medicinal Chemistry, 2020, 187, pp.111939. ⟨10.1016/j.ejmech.2019.111939⟩ Article dans une revue hal-02421051v1
Synthesis and antibacterial evaluation of bis-thiazolium, bis- imidazolium and bis-triazolium derivatives Benoît Thomas,Raphael E Duval,Stéphane Fontanay,Mihayl Varbanov,Michel Boisbrun ChemMedChem, 2019, 14 (13), pp.1232-1237. ⟨10.1002/cmdc.201900151⟩ Article dans une revue hal-02146002v1
Synthesis and evaluation of new designed multiple ligands directed towards both peroxisome proliferator-activated receptor-γ and angiotensin II type 1 receptor Maxime Meyer,Sébastien Foulquier,François Dupuis,Stéphane Flament,Linda Grimaudet al. European Journal of Medicinal Chemistry, 2018, 158, pp.334-352. ⟨10.1016/j.ejmech.2018.08.082⟩ Article dans une revue hal-01905470v1
Biotinylation enhances the anticancer effects of 15d-PGJ2 against breast cancer cells Christelle Colin,Maxime Meyer,Claudia Cerella,Alexandra Kleinclauss,Gérald Monardet al. International Journal of Oncology, 2018, 52 (6), pp.1991-2000. ⟨10.3892/ijo.2018.4338⟩ Article dans une revue hal-01824428v1
Pro-apoptotic effect of Δ2-TGZ in &quot;claudin-1-low&quot; triple-negative breast cancer cells: involvement of claudin-1 Marine Geoffroy,Alexandra Kleinclauss,Stéphanie Grandemange,Sébastien Hupont,Michel Boisbrunet al. Breast Cancer Research and Treatment, 2017, 165 (3), pp.517-527. ⟨10.1007/s10549-017-4378-2⟩ Article dans une revue hal-01589665v1
Δ2-Troglitazone promotes cytostatic rather than pro-apoptotic effects in breast cancer cells cultured in high serum conditions Audrey Berthe,Stéphane Flament,Stéphanie Grandemange,Marie Zaffino,Michel Boisbrunet al. Cell Cycle, 2016, 15 (24), pp.3402-3412. ⟨10.1080/15384101.2016.1245248⟩ Article dans une revue hal-01411104v1
Stimulating effect of both 4’- O -methylnorbelladine feeding and temporary immersion conditions on galanthamine and lycorine production by Leucojum aestivum L. bulblets Sahar Saliba,Agata Ptak,Michel Boisbrun,Rosella Spina,François Dupireet al. Engineering in Life Sciences, 2016, 16 (8), pp.731-739. ⟨10.1002/elsc.201600045⟩ Article dans une revue istex hal-02087800v1
Reprofiling of troglitazone towards more active and less toxic derivatives: a new hope for cancer treatment? Sabine Mazerbourg,Sandra Kuntz,Isabelle Grillier-Vuissoz,Audrey Berthe,Marine Geoffroyet al. Current Topics in Medicinal Chemistry, 2016, 16 (19), pp.2115-2124. ⟨10.2174/1568026616666160216153036⟩ Article dans une revue hal-01281602v1
PPARγ-inactive Δ2-troglitazone independently triggers ER stress and apoptosis in breast cancer cells. Christelle Colin-Cassin,Xiao Yao,Claudia Cerella,Sarra Chbicheb,Sandra Kuntzet al. Molecular Carcinogenesis, 2015, 54 (5), pp.393-404. ⟨10.1002/mc.22109⟩ Article dans une revue istex hal-00917939v1
From D-glucuronic acid to L-iduronic acid derivatives via a radical tandem decarboxylation-cyclization Stephane Salamone,Michel Boisbrun,Claude Didierjean,Yves Chapleur Carbohydrate Research, 2014, 386, pp.99-105. ⟨10.1016/j.carres.2014.01.006⟩ Article dans une revue hal-01494402v1
Synthesis and anti-proliferative activity of new biphenyle-benzylidenethiazolidine-2,4-dione bis-adducts containing various heterocyclic cores Maxime Meyer,Sandra Kuntz,Isabelle Grillier-Vuissoz,Hélène Martin,Lysiane Richertet al. Letters in Drug Design and Discovery, 2014, 11 (3), pp.256-264. ⟨10.2174/15701808113106660080⟩ Article dans une revue hal-01094215v1
Optimization of troglitazone derivatives as potent anti-proliferative agents: towards more active and less toxic compounds. Andrea Bordessa,Christelle Colin-Cassin,Isabelle Grillier-Vuissoz,Sandra Kuntz,Sabine Mazerbourget al. European Journal of Medicinal Chemistry, 2014, 83, pp.129-140. ⟨10.1016/j.ejmech.2014.06.015⟩ Article dans une revue istex hal-01094210v1
Energy restriction mimetic agents to target cancer cells: Comparison between 2-deoxyglucose and thiazolidinediones. Sandra Kuntz,Sabine Mazerbourg,Michel Boisbrun,Claudia Cerella,Marc Diederichet al. Biochemical Pharmacology, 2014, 92 (1), pp.102-111. ⟨10.1016/j.bcp.2014.07.021⟩ Article dans une revue istex hal-01094216v1
Synthesis of new troglitazone derivatives: Anti-proliferative activity in breast cancer cell lines and preliminary toxicological study Stéphane Salamone,Christelle Colin,Isabelle Grillier-Vuissoz,Sandra Kuntz,Sabine Mazerbourget al. European Journal of Medicinal Chemistry, 2012, 51, pp.206-215. ⟨10.1016/j.ejmech.2012.02.044⟩ Article dans une revue istex hal-00746870v1
PPARγ-independent activity of thiazolidinediones: a promising mechanism of action for new anticancer drugs? Isabelle Grillier-Vuissoz,Sabine Mazerbourg,Michel Boisbrun,Sandra Kuntz,Yves Chapleuret al. Journal of Carcinogenesis & Mutagenesis, 2012, pp.S8:002. ⟨10.4172/2157-2518.S8-002⟩ Article dans une revue hal-00747318v1
Structure-Activity Relationships and Drug Allergy Frédéric Hasdenteufel,Samuel Luyasu,Nicolas Hougardy,Malcolm Fisher,Michel Boisbrunet al. Current Clinical Pharmacology, 2012, 7 (1), pp.15-27. ⟨10.2174/157488412799218815⟩ Article dans une revue hal-02186020v1
EGR1 expression: a calcium and ERK1/2 mediated PPAR-independent event involved in the antiproliferative effect of 15-deoxy-(12,14-prostaglandin J2 and Thiazolidinediones in breast cancer cells Sarra Chbicheb,Xiao Yao,Jean-Luc Rodeau,Stéphane Salamone,Michel Boisbrunet al. Biochemical Pharmacology, 2011, 81 (9), pp.1087. ⟨10.1016/j.bcp.2011.02.006⟩ Article dans une revue istex hal-00685074v1
Kinetic study of the rearrangement of deuterium-labeled 4'-O-methylnorbelladine in Leucojum aestivum shoot cultures by mass spectrometry. Influence of precursor feeding on amaryllidaceae alkaloid accumulation. Anna El Tahchy,Agata Ptak,Michel Boisbrun,Elvina Barre,Catherine Guillouet al. Journal of Natural Products, 2011, 74 (11), pp.2356-2361. ⟨10.1021/np200285j⟩ Article dans une revue hal-00662945v1
New method for the study of Amaryllidaceae alkaloid biosynthesis using biotransformation of deuterium-labeled precursor in tissue cultures. Anna El Tahchy,Michel Boisbrun,Agata Ptak,François Dupire,François Chrétienet al. Acta Biochimica Polonica, 2010, 57 (1), ⟨10.18388/abp.2010_2375⟩ Article dans une revue hal-02186004v1
New troglitazone derivatives devoid of PPARγ agonist activity display an increased antiproliferative effect in both hormone-dependent and hormone-independent breast cancer cell lines Christelle Colin,Stéphane Salamone,Isabelle Grillier-Vuissoz,Michel Boisbrun,Sandra Kuntzet al. Breast Cancer Research and Treatment, 2010, 124 (1), pp.101-110. ⟨10.1007/s10549-009-0700-y⟩ Article dans une revue istex hal-00526202v1
Exploration of potential prodrug approach of the bis-thiazolium salts T and T4 for orally delivered antimalarials. S. Caldarelli,Michel Boisbrun,Karine Alarcon,Abdallah Hamzé,Mahama Ouattaraet al. Bioorganic and Medicinal Chemistry Letters, 2010, 20, pp.3953-3956. ⟨10.1016/j.bmcl.2010.05.001⟩ Article dans une revue istex hal-00501627v1
Design and photophysical properties of new RGD targeted tetraphenylchlorins and porphyrins Michel Boisbrun,Régis Vanderesse,Philippe Engrand,Alexis Olié,Sébastien Hupontet al. Tetrahedron, 2008, 64 (16), pp.3494-3504. ⟨10.1016/j.tet.2008.01.142⟩ Article dans une revue istex hal-00241268v1
Disruption of ERα signalling pathway by PPARγ agonists: evidences of PPARγ-independent events in two hormone-dependent breast cancer cell lines Julie Lecomte,Stéphane Flament,Stéphane Salamone,Michel Boisbrun,Sabine Mazerbourget al. Breast Cancer Research and Treatment, 2008, 112 (3), pp.437-451. ⟨10.1007/s10549-007-9886-z⟩ Article dans une revue istex hal-04417363v1
Diastereocontrolled multicomponent pathway to 3,4-heterocycle-annulated tetrahydro-b-carbolines Emmanuel Dardennes,Arpad Kovacs-Kulyassa,Michel Boisbrun,Christian Petermann,Jean-Yves Laronzeet al. Tetrahedron: Asymmetry, 2005, 16, pp.1329-1339 Article dans une revue hal-00019131v1
Synthesis and anticancer activity of new pyrrolocarbazoles and pyrrolo-β-carbolines Marie Laronze,Michel Boisbrun,S. Leonce,B. Pfeiffer,P. Renardet al. Bioorganic and Medicinal Chemistry, 2005, 13, pp.2263-2283 Article dans une revue hal-00020821v1

Brevet (2)

Process of preparation of L-iduronic acid comprising a decarboxylation/intramolecular cyclisation tandem reaction Stéphane Salamone,Yves Chapleur,Michel Boisbrun France, Patent n° : EP 2 578 594A1. 2013 Brevet hal-02276275v1
Dérivés de thiazolidinedione, leur préparation et leur utilisation dans le traitement des cancers Michel Boisbrun,Yves Chapleur,Andrea Bordessa,Stéphane Flament,Isabelle Grillier-Vuissozet al. France, N° de brevet: FR2986231A1. SBS. 2013 Brevet hal-00920599v1

Communication dans un congrès (32)

Desulfured troglitazone derivatives: improvement of the antiproliferative activity Dorian Dupommier,Claire Muller,Corinne Comoy,Sabine Mazerbourg,Andrea Bordessaet al. Journées de Chimie Organique, JCO 2019, Siciété Chimique de France, Oct 2019, Palaiseau, France Communication dans un congrès hal-02335964v1
Potential interest of troglitazone derivatives for the treatment of cancer Claire Muller,Dorian Dupommier,Badrul H Yahaya,Md Toha Zaleha,Sabine Mazerbourget al. 5th USM-UL colloquium, Aug 2019, Penang, Malaysia Communication dans un congrès hal-02417125v1
Modulation of claudin-1 expression by ∆2-TGZ in triple negative breast cancer cells is correlated to apoptosis Marine Geoffroy,Alexandra Kleinclauss,Michel Boisbrun,Marine Lemesle,Stéphane Flamentet al. 20th World Congress of Senologic International Society on Breast HealthCare, Dec 2018, Strasbourg, France Communication dans un congrès hal-01947874v1
A new derivative of troglitazone affects energy metabolism of triple negative breast cancer cells: potential interest for anticancer treatment Claire Muller,Stéphanie Grandemange,Jerome Kluza,Frédéric Bost,Eline Piquardet al. 11ème Forum du Cancéropôle Est, Nov 2018, Reims, France Communication dans un congrès hal-01937228v1
Energy metabolism alteration and anticancer treatment: study of a troglitazone derivative in triple-negative breast cancer cells Claire Muller,Stéphanie Grandemange,Jerome Kluza,Frédéric Bost,Eline Piquardet al. Cancer and Metabolism 2018, Jun 2018, Cambridge, United Kingdom Communication dans un congrès hal-01946195v1
Modulation of claudin-1 expression by ∆2-TGZ in triple negative breast cancer. Marine Geoffroy,Alexandra Kleinclauss,Michel Boisbrun,Stéphane Flament,Sandra Kuntzet al. Make it personal: precision medicine - European Association for Cancer Research conference series, Mar 2017, Amsterdam, Netherlands Communication dans un congrès hal-02278135v1
Modulation of claudin 1 expression by ∆2-TGZ in triple negative breast cancer cells is correlated to apoptosis. Marine Geoffroy,Alexandra Kleinclauss,Gauthier Husson,Michel Boisbrun,Stéphane Flamentet al. 18° journée scientifique de la Ligue contre le Cancer, Nov 2017, Illkirch, France Communication dans un congrès hal-02278076v1
Modulation of claudin-1 expression by ∆2-TGZ in triple negative breast cancer cells is correlated to apoptosis Marine Geoffroy,Alexandra Kleinclauss,Michel Boisbrun,Stéphane Flament,Sandra Kuntzet al. 2nd EACR-OECI Conference Making it Personal - Cancer Precision Medicine, Mar 2017, Amsterdam, Netherlands Communication dans un congrès hal-01665256v1
Le « drug reprofiling » appliqué à la troglitazone : vers un nouveau traitement anticancéreux ? Michel Boisbrun,Andrea Bordessa,Audrey Berthe,Marine Geoffroy,Hélène Martinet al. 16èmes REncontres de Chimie Organique Biologique, Recob.16, Mar 2016, Aussois, France Communication dans un congrès hal-01416900v1
Effets précoces de dérivés troglitazone dans les cellules cancéreuses mammaires « claudin 1-low ». Marine Geoffroy,Alexandra Kleinclauss,Levy Batistat,Michel Boisbrun,Muriel Barberi-Heyobet al. 10ème forum du Cancéropole Grand-Est, Cancéropole Grand-Est, Dec 2016, Nancy, France Communication dans un congrès hal-01407174v1
Le repositionnement de la TGZ, une stratégie intéressante pour le traitement des tumeurs mammaires triple-négatives? Isabelle Grillier-Vuissoz,Sandra Kuntz,Sabine Mazerbourg,Christelle Colin-Cassin,Marine Geoffroyet al. 3ème Journée d’échanges sur la recherche en cancérologie en Lorraine, ICL, Oct 2016, Vandoeuvre-lès-Nancy, France Communication dans un congrès hal-01418787v1
Delta-2-Troglitazone targets mitochondria in triple-negative breast cancer cells: a metabolic change contributing to sensitization of cancer cells to chemotherapy? Audrey Berthe,Stéphanie Grandemange,Michel Boisbrun,Bost Frédéric,Marie Zaffinoet al. 9e Forum du Cancéropôle Grand Est , Nov 2015, Strasbourg, France Communication dans un congrès hal-01243561v1
Modulation of Claudin-1 expression by thiazolidinediones in breast cancer cells. Marine Geoffroy,Gauthier Husson,Alexandra Kleinclauss,Michel Boisbrun,Stéphane Flamentet al. 2nd International Symposium of the Cancer Research Center of Lyon, CRCL 2015, Sep 2015, Lyon, France Communication dans un congrès hal-01242179v1
Thiazolidinediones derivatives: a promising compounds for the treatment of Claudin-1 low breast cancer cells Marine Geoffroy,Gauthier Husson,Alexandra Kleinclauss,Michel Boisbrun,Stéphane Flamentet al. 9e Forum du Cancéropole Grand-Est, Nov 2015, Strasbourg, France Communication dans un congrès hal-01242191v1
Delta2-Troglitazone alters energetic metabolism in triple-negative breast cancer cells: a mechanism to sensitize cancer cells to chemotherapy? Audrey Berthe,Stéphanie Grandemange,Michel Boisbrun,Frédéric Bost,Stéphane Flamentet al. Journée d’Echanges sur la Recherche en Cancérologie en Lorraine, Nov 2015, Vandoeuvre-lès-Nancy, France Communication dans un congrès hal-01820259v1
Modulation of Claudin-1 expression by thiazolidinediones in breast cancer cells. Marine Geoffroy,Gauthier Husson,Alexandra Kleinclauss,Michel Boisbrun,Sandra Kuntzet al. Deuxième Journée d’Echanges sur la Recherche en Cancérologie en Lorraine : Approches innovantes dans le diagnostic et les traitements des cancers, Institut de Cancérologie de Lorraine (ICL) Nov 2015, Vandoeuvre-les-Nancy, France Communication dans un congrès hal-01242156v1
Les dérivés de TZD : une piste prometteuse pour le traitement des tumeurs triple-négatives &quot;claudine 1 low&quot; ? Marine Geoffroy,Gauthier Husson,Alexandra Kleinclauss,Michel Boisbrun,Stéphane Flamentet al. Journée d’Echanges sur la Recherche en Cancérologie en Lorraine. La personnalisation du diagnostic et des traitements, Institut de cancérologie de Lorraine, Sep 2014, Vandoeuvre -les-Nancy, France Communication dans un congrès hal-01094494v1
∆2-Troglitazone and 2-Deoxyglucose inhibit breast cancer cell proliferation: a consequence of the alteration of the cancer cell metabolism? Audrey Berthe,Michel Boisbrun,Stéphane Flament,Sabine Mazerbourg 8ème forum du Cancéropôle Grand-Est, Nov 2014, Strasbourg, France Communication dans un congrès hal-01094607v1
Optimization of troglitazone derivatives as potent anti-proliferative agents: towards more active and less toxic compounds Andrea Bordessa,Christelle Colin-Cassin,Isabelle Grillier-Vuissoz,Sandra Kuntz,Sabine Mazerbourget al. 50th International Conference on Medicinal Chemistry, RICT 2014, Jul 2014, Rouen, France Communication dans un congrès hal-01094539v1
The potential energy restriction mimetic agent Delta2-troglitazone independently triggers ER stress and apoptosis in breast cancer cells Christelle Colin-Cassin,Xiao Yao,Claudia Cerella,Audrey Berthe,Sarra Chbichebet al. Metabolism 2014. Alterations of metabolic pathways as therapeutic targets, Jan 2014, Esch-sur Alzette, Luxembourg Communication dans un congrès hal-01094413v1
Les dérivés de TZD: une piste prometteuse pour le traitement des tumeurs triple-négatives &quot;claudine 1 low&quot; ? Marine Geoffroy,Gauthier Husson,Alexandra Kleinclauss,Michel Boisbrun,Stéphane Flamentet al. 8ème forum du Cancéropole Grand-Est, Nov 2014, Strasbourg, France Communication dans un congrès hal-01094501v1
The potential energy restriction mimetic agent delta2-troglitazone independently triggers ER stress and apoptosis in breast cancer cells Christelle Colin-Cassin,Xiao Yao,Claudia Cerella,Audrey Berthe,Sarra Chbichebet al. Metabolism 2014: Alterations of metabolic pathways as therapeutic targets, Marc Diederich, Jan 2014, Esch-sur-Alzette, Luxembourg Communication dans un congrès hal-01095563v1
Effects of the potential energy restriction mimetic agent delta2-troglitazone in breast cancer cells Isabelle Grillier-Vuissoz,Christelle Colin-Cassin,Xiao Yao,Claudia Cerella,Audrey Bertheet al. 23rd Biennial Congress of the European Association for Cancer Research, EACR-23, Jul 2014, Munich, Germany. pp.S57-S58 Communication dans un congrès hal-01094634v1
Effets PPARgamma indépendants des glitazones : vers le développement de dérivés de troglitazone à visée anticancéreuse Michel Boisbrun,Andrea Bordessa,Stéphane Salamone,M. Vo,Christelle Colinet al. 14èmes Rencontres en Chimie Organique Biologique, RECOB 14, Mar 2012, Aussois, France. pp.CDROM Communication dans un congrès hal-00747910v1
Synthèse de nouveaux dérivés de troglitazone à visée anticancéreuse Michel Boisbrun,Andrea Bordessa,Stéphane Salamone,M. Vo,Christelle Colinet al. Congrès SCF Grand-Est 7, Mar 2012, Reims, France. pp.CDROM Communication dans un congrès hal-00747913v1
Etude du facteur de transcription précoce Nur77/NR4A1 dans les cellules cancéreuses mammaires : intérêt pour la compréhension du mode d'action des thiazolidinediones Ali Karoune,Xiao Yao,Michel Boisbrun,Yves Chapleur,Sandra Kuntzet al. 6ème Forum du Cancéropole Grand-Est, Nov 2012, Strasbourg, France Communication dans un congrès hal-00747532v1
Design, synthesis, docking studies, and evaluation of losartan derivatives with potential dual activity at angiotensine II type 1 receptor and Peroxisome Proliferator Activated Receptor gamma Maxime Meyer,Sébastien Foulquier,Gerald Monard,François Dupuis,Isabelle Grillier-Vuissozet al. 4th Congress of the European Association for Chemical and Molecular Sciences, EuCheMS'2012, Aug 2012, Prague, Czech Republic. pp.CDROM Communication dans un congrès hal-00747370v1
Elaboration de nouveaux dérivés de thiazolidinediones à activité PPARgamma-indépendante pour le traitement des cancers mammaires Christelle Colin,Stéphane Flament,Michel Boisbrun,Hélène Martin,Yves Chapleuret al. 7ème Journée Claude HURIET de Recherche Biomédicale du CHU & Faculté de Médecine de Nancy, Mar 2012, Vandoeuvre-les-Nancy, France Communication dans un congrès hal-00747515v1
Nouveaux dérivés du losartan à double activité antagoniste des récepteurs de l'angiotensine II et agonistes des PPAR-gamma Maxime Meyer,Sébastien Foulquier,Gerald Monard,François Dupuis,Isabelle Grillier-Vuissozet al. 32èmes Journées de l'Hypertension Artérielle, Dec 2012, Paris, France. pp.CO-30 Communication dans un congrès hal-00777144v1
New thiazolidinedione derivatives with PPARg-independent activity: high inhibition of breast cancer cell proliferation with low toxicity towards human hepatocytes Christelle Colin,Sarra Chbicheb,Xiao Yao,Andrea Bordessa,Michel Boisbrunet al. 22nd Biennial Congress of the European Association for Cancer Research, EACR-22, Jul 2012, Barcelone, Spain. pp.CDROM, ⟨10.1016/S0959-8049(12)71613-1⟩ Communication dans un congrès hal-00747357v1
PPARgamma-independent effects of thiazolidinediones: a promising mechanism for new anticancer drugs Christelle Colin,Sarra Chbicheb,Michel Boisbrun,Isabelle Grillier-Vuissoz,Sandra Kuntzet al. 5ème Forum du Cancéropôle Grand-Est, Nov 2011, Strasbourg, France Communication dans un congrès hal-00747832v1
PPARgamma-independent activity of thiazolidinediones: a promising mechanism of action for new anticancer drugs Christelle Colin,Sarra Chbicheb,Michel Boisbrun,Isabelle Grillier-Vuissoz,Sandra Kuntzet al. 2ème Colloque Inter-régional Grand-Est de Recherche Translationnelle en Oncologie, ONCOTRANS 2011, Sep 2011, Nancy, France Communication dans un congrès hal-00747856v1

Poster de conférence (9)

Identification de la tubuline comme une cible du composé anticancéreux AB186 par une analyse protéomique basée sur une approche Surface Plasmon Resonance (SPR)-Mass Spectrometry (MS) Sabine Mazerbourg,Michel Boisbrun,Wilfrid Boireau,Alain Rouleau,Marine Geoffroyet al. 14e Forum Cancéropôle Est, Nov 2025, Besançon, France Poster de conférence hal-05412194v1
Convenient synthesis of substituted thiazolo [4,5-b] quinolines Elodie Cortelazzo-Polisini,Michel Boisbrun,Axel Gansmuller,Corinne Comoy BOSS XVII 17th Belgian Organic Synthesis Symposium, Jul 2022, Namur, Belgium. Poster de conférence hal-03975258v1
Synthesis of new desulfured troglitazone derivatives with improved anti-proliferative activity Dorian Dupommier,Claire Muller,Andrea Bordessa,Eline Piquard,Manon Pawlaket al. 17e Rencontres en Chimie Organique Biologique, RECOB17, Mar 2018, Aussois, France Poster de conférence hal-01946177v1
Synthesis and antibacterial evaluation of new bis-thiazolium, bis-imidazolium, and bis-triazolium derivatives. Benoît Thomas,Stéphane Fontanay,Raphaël E. Duval,Michel Boisbrun RICT 2017 : 53th International Conference on Medicinal Chemistry, Jul 2017, Toulouse, France Poster de conférence hal-02278103v1
Delta-2-troglitazone sensitizez triple-negative breast cancer cells to chemotherapy: a consequence of mitochondrial dysfunction? Audrey Berthe,Stéphanie Grandemange,Michel Boisbrun,Bost Frédéric,Marie Zaffinoet al. 6th World Congress on Targeting Mitochondria, Oct 2015, Berlin, Germany. 2015 Poster de conférence hal-01214922v1
D2-Troglitazone alters energetic metabolism in triple-negative breast cancer cells: a mechanism to sensitize cancer cells to chemotherapy? Audrey Berthe,Stéphanie Grandemange,Michel Boisbrun,Bost Frédéric,Stéphane Flamentet al. Cancer and Metabolism conference, 2015, Sep 2015, Cambridge, United Kingdom. Poster de conférence hal-01214915v1
Influence of both 4,-O-methylnorbelladine feeding and temporary immersion conditions on galanthamine and lycorine production by leucojum aestivum bulblets. Sahar Saliba,Agata Ptak,Michel Boisbrun,François Dupire,Dominique Laurain-Mattar 9th Internationnal Symposium on Chromatography of naturel Products, May 2014, Lublin (POL), Poland Poster de conférence hal-04556929v1
Anchorage of ∆2-Troglitazone on the dendrimer PAMAM demonstrates that early events in breast cancer cells occur independently of a nuclear action Audrey Berthe,Andrea Bordessa,Michel Boisbrun,Stéphane Flament,Sabine Mazerbourg 7ème forum Cancéropôle Grand-Est, Nov 2013, Strasbourg, France. page 40 résumé 31 Poster de conférence hal-00919936v1
Elicitation of galanthamine and lycorine biosynthetic pathway with deuterium-labelled-4’-O-methylnorbelladine added to leucojum aestivum bulblets. Sahar Saliba,Agata Ptak,Michel Boisbrun,François Dupire,Dominique Laurain-Mattar AFERP & STOLON International Symposium, May 2013, Brussel, Belgium Poster de conférence hal-04556928v1