Mickael Di-Luoffo Chercheur post-doctorant

Identifiants chercheurs

IdHAL :

mickael-di-luoffo

ORCID :

0000-0003-0537-6501

ResearcherID :

http://www.researcherid.com/rid/W-8015-2019

Publications

Communication dans un congrès (17)

Impact of mechanical compressive stress on pancreatic cancer progression Mickael Di-Luoffo,Silvia Arcucci,Tristan Marty,Nicole Therville,Sanzhar Aitbayet al. de Duve institut (Brussels), de Duve institut, Jun 2025, Bruxelles, Belgium Communication dans un congrès hal-05301039v1
PI3K signaling controls metabolic adaptations in pancreatic cancer Coralie Cayron,Benoît Thibault,Silvia Arcucci,Mickael Di-Luoffo,Nicole Thervilleet al. 46th Symposium on hormones and cell regulation - Cancer signalling and metabolism, Oct 2024, Mont Sainte Odile, France Communication dans un congrès hal-04922360v1
Imaging the 3D cellular effects of compression in oncology: Application in pancreatic cancer Romina D’Angelo,Silvia Arcucci,Nicole Therville,Celine Denais,Morgan Delarueet al. Atelier pour le 1st meeting of the France-BioImaging Mechanobiology WG, Mechanobiology Working Group FBI, Dec 2024, Toulouse, France Communication dans un congrès hal-04908796v1
Oral bacteria accelerate pancreatic cancer development in mice Mickael Di-Luoffo 38ième réunion du Club Français du Pancréas, Sep 2024, Toulouse, France Communication dans un congrès hal-04908702v1
Mechanical stress & signal integration by PI3Ks for the control of tumour growth. Sanzhar Aitbay,Hala Shalhoub,Romina D’Angelo,Nicole Therville,Silvia Arcucciet al. 4th PIPgen annual meeting, PIPgen, Sep 2024, Cambridge, United Kingdom Communication dans un congrès hal-04924047v1
Inflammation-induced epithelial plasticity can be by-passed through Vps34 inactivation to limit pancreatic cancer initiation Benoît Thibault,Fernanda Ramos-Delgado,Hala Shalhoub,Camille Guyon,Handschin Charleset al. GSO Annual Meeting, Nov 2023, Arcachon, France Communication dans un congrès hal-04915257v1
Mechanics & Genetics of pancreatic cancer Mechanical compressive stress favors selective mutational contexts and intracellular signaling during pancreatic cancer development Mickael Di-Luoffo,Silvia Arcucci,Tristan Marty,Nicole Therville,Sanzhar Aitbayet al. PANCREATIC CANCER SYMPOSIUM AFRCP 2023, Oct 2023, Bordeaux, France Communication dans un congrès hal-04908777v1
Impact of mechanical compressive stress on pancreatic cancer progression Mickael Di-Luoffo,Nicole Therville,Silvia Arcucci,Romina D’Angelo,Benoît Thibaultet al. Mechanobiology Club of Toulouse, Jan 2023, Toulouse, France Communication dans un congrès hal-04908762v1
La plasticité épithéliale induite par l'inflammation peut être contournée par l'inactivation de Vps34 pour limiter l'initiation du cancer du pancréas Benoît Thibault,Fernanda Ramos-Delgado,Hala Shalhoub,Camille Guyon,Charles Handschinet al. Club Français du Pancréas, Sep 2023, Lille, France Communication dans un congrès hal-04915308v1
PI3Kα and PI3Kγ cooperation: a new target to limit metabolic heterogeneity in pancreatic cancer Coralie Cayron,Benoît Thibault,Mickael Di-Luoffo,Nicole Therville,Camille Guyonet al. Workshop oncogenic pathways in cancer, Mar 2023, Toulouse, France Communication dans un congrès hal-04922379v1
Impact of mechanical compressive stress on pancreatic cancer progression Mickael Di-Luoffo,Nicole Therville,Benoit Thibault,Morgan Delarue,Julie Guillermet-Guibert Axe 1 : voies oncogéniques du cancer, Dec 2022, Toulouse, France Communication dans un congrès hal-04908623v1
La croissance sous pression impacte la progression et le traitement du cancer du pancréas Mickael Di-Luoffo,Nicole Therville,Sanzhar Aitbay,Pauline Lefebvre,Morgan Delarueet al. Club Français du Pancréas 2022, Sep 2022, Paris, France Communication dans un congrès hal-04908684v1
PI3K signaling and tumoral metabolism in pancreatic cancer Coralie Cayron,Benoît Thibault,Mickael Di-Luoffo,Nicole Therville,Camille Guyonet al. Congrès annuel du Cancéropole Grand Sud-Ouest, Nov 2021, Carcassonne, France Communication dans un congrès hal-04922370v1
PI3K signaling and tumoral metabolism in pancreatic cancer Coralie Cayron,Benoît Thibault,Mickael Di-Luoffo,Nicole Therville,Camille Guyonet al. Congrès annuel de l'AFRCP, Nov 2021, Clichy, France Communication dans un congrès hal-04922364v1
Tumor progression in bile duct cancer Mickael Di-Luoffo,S Pirenne,T Saandi,A Loriot,C Gérardet al. CRCT Scientific Animation, Jul 2020, Toulouse, France Communication dans un congrès hal-04908585v1
MEF2 and COUP-TFII cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells Mickaël Di-Luoffo,Catherine Brousseau,Raifish E. Mendoza Villarroel,Jacques J. Tremblay RQR 2015, Nov 2015, Montreal (Canada), Canada Communication dans un congrès hal-04906977v1
The MEF2 transcription factor regulates Gsta1 gene expression in MA-10 Leydig cells Mickaël Di-Luoffo,Catherine Brousseau,Francis Bergeron,Jacques J. Tremblay RQR 2014, Nov 2014, Québec (Canada), Canada Communication dans un congrès hal-04906959v1

Article dans une revue (10)

Mechanical compressive forces increase PI3K output signaling in breast and pancreatic cancer cells Mickaël Di-Luoffo,Céline Schmitter,Emma C Barrere,Nicole Therville,Maria Chaoukiet al. Life Science Alliance, 2025, 8 (3), pp.e202402854. ⟨10.26508/lsa.202402854⟩ Article dans une revue hal-04874687v1
Transducing compressive forces into cellular outputs in cancer and beyond Céline Schmitter,Mickaël Di-Luoffo,Julie Guillermet-Guibert Life Science Alliance, 2023, 6 (9), pp.e202201862. ⟨10.26508/lsa.202201862⟩ Article dans une revue hal-04821449v1
A microfluidic mechano-chemostat for tissues and organisms reveals that confined growth is accompanied with increased macromolecular crowding Zacchari Ben Meriem,Tiphaine Mateo,Julien Faccini,Céline Denais,Romane Dusfour-Castanet al. Lab on a Chip, 2023, 20, pp.4445-4455. ⟨10.1039/d3lc00313b⟩ Article dans une revue hal-04214597v1
The nuclear receptors SF1 and COUP-TFII cooperate on the Insl3 promoter in Leydig cells Mickaël Di-Luoffo,Kenley Joule Pierre,Nicholas M Robert,Marie-Joëlle Girard,Jacques J Tremblay Reproduction [Cambridge], 2022, ⟨10.1530/rep-22-0109⟩ Article dans une revue hal-04891620v1
PI3K functions as a hub in mechanotransduction M. Di-Luoffo,Zacchari Ben-Meriem,P. Lefebvre,Morgan Delarue,Julie Guillermet-Guibert Trends in Biochemical Sciences, 2021, 46 (11), pp.878-888. ⟨10.1016/j.tibs.2021.05.005⟩ Article dans une revue hal-03252135v1
Dynamics and predicted drug response of a gene network linking dedifferentiation with beta-catenin dysfunction in hepatocellular carcinoma Claude Gérard,Mickaël Di-Luoffo,Léolo Gonay,Stefano Caruso,Gabrielle Couchyet al. Journal of Hepatology, 2019, 71 (2), ⟨10.1016/j.jhep.2019.03.024⟩ Article dans une revue hal-04888966v1
MEF2 Cooperates With Forskolin/cAMP and GATA4 to Regulate Star Gene Expression in Mouse MA-10 Leydig Cells Caroline Daems,Mickaël Di-Luoffo,Élise Paradis,Jacques J Tremblay Endocrinology, 2015, 156 (7), pp.2693-2703. ⟨10.1210/en.2014-1964⟩ Article dans une revue hal-04891040v1
Novel Targets for the Transcription Factors MEF2 in MA-10 Leydig Cells1 Mickaël Di-Luoffo,Caroline Daems,Francis Bergeron,Jacques J Tremblay Biology of Reproduction, 2015, 93 (1), ⟨10.1095/biolreprod.114.127761⟩ Article dans une revue hal-04891337v1
The Transcription Factor MEF2 Is a Novel Regulator of Gsta Gene Class in Mouse MA-10 Leydig Cells Mickaël Di-Luoffo,Catherine Brousseau,Francis Bergeron,Jacques J Tremblay Endocrinology, 2015, 156 (12), pp.4695 - 4706. ⟨10.1210/en.2015-1500⟩ Article dans une revue hal-04891150v1
The INSL3 gene is a direct target for the orphan nuclear receptor, COUP-TFII, in Leydig cells Raifish E Mendoza-Villarroel,Mickaël Di-Luoffo,Etienne Camiré,Xavier C Giner,Catherine Brousseauet al. Journal of Molecular Endocrinology, 2014, 53 (1), pp.43-55. ⟨10.1530/jme-13-0290⟩ Article dans une revue hal-04890889v1

Pré-publication, Document de travail (2)

Mutants of p53 sustain tumor growth under mechanical compression Mickael Di-Luoffo,Silvia Arcucci,Nicole Therville,Tristan Marty,Romina D’Angeloet al. 2025 Pré-publication, Document de travail hal-05346744v1
The biomechanical context influences the PI3K output signaling in breast and pancreatic cancer cells M. Di-Luoffo,C. Schmitter,E.C. Barrere,N. Therville,Morgan Delarueet al. 2022 Pré-publication, Document de travail hal-03808261v1

Poster de conférence (19)

Pancreatic cancer cells adapt to compressive mechanical stress through regulation of PI3K – MAPK interdynamics. Sanzhar Aitbay,Nicole Therville,Mickael Di-Luoffo,Hala Shalhoub,Romina D’Angeloet al. 48th FEBS Congress – ‘Mining biochemistry for human health and well-being’, Jun 2024, Milano, Italy. , 2024 Poster de conférence hal-04923950v1
PI3K signaling controls metabolic adaptations in pancreatic cancer Benoît Thibault,Coralie Cayron,Mickael Di-Luoffo,Nicole Therville,Camille Guyonet al. EACR Annual Meeting, Jun 2024, Rotterdam, Netherlands. 2024 Poster de conférence hal-04915342v1
PI3K signaling controls metabolic adaptations in pancreatic cancer Coralie Cayron,Benoît Thibault,Silvia Arcucci,Mickael Di-Luoffo,Nicole Thervilleet al. 46th Symposium on Hormones and cell regulation - Cancer signalling and metabolism, Oct 2024, Mont Sainte Odile, France Poster de conférence hal-04922358v1
Imaging the 3D cellular effects of confinement in oncology: Application in pancreatic cancer Romina D’Angelo,Silvia Arcucci,Laetitia Ligat,Nicole Therville,Celine Denaiset al. Signaling, Microenvironment and Targeting - GSO Workshop, Feb 2024, Toulouse, France. 2024 Poster de conférence hal-04917240v1
“TREATING B CELL LYMPHOMA PATIENTS WITH INHIBITORS OF PI3Kδ (PHOSPHOINOSITIDE 3-KINASES): how to increase the efficacy?” Maria Chaouki,Anne Quillet-Mary,Benoît Thibault,Loic Ysebaert,Michael Lahnet al. 46 th Symposium on Hormones and Cell Regulation, Oct 2024, STRASBOURG (FRANCE), France Poster de conférence hal-04919848v1
Inflammation-induced epithelial plasticity can be by-passed through Vps34 inactivation to limit pancreatic cancer initiation Benoît Thibault,Fernanda Ramos-Delgado,Hala Shalhoub,Camille Guyon,Charles Handschinet al. Biochemical Society: PI3K/PTEN pathway: a new era in basic research & clinical translation, Sep 2023, Barcelona, Spain. 2023 Poster de conférence hal-04915379v1
Targeting PI3K pathway in pancreatic cancer reduces metabolic flexibility and sensitises tumour to new therapeutic strategies Coralie Cayron,Benoît Thibault,Mickael Di-Luoffo,Nicole Therville,Camille Guyonet al. PI3K pathway meeting, Sep 2023, Casteldefels, Barcelona, Spain Poster de conférence hal-04922344v1
“TREATING B CELL LYMPHOMA PATIENTS WITH INHIBITORS OF PI3Kδ (PHOSPHOINOSITIDE 3-KINASES): how to increase the efficacy?” Maria Chaouki,Anne Quillet-Mary,Loic Ysebaert,Benoît Thibault,Mickael Di-Luoffoet al. PI3K/PTEN pathway: a new era in basic research & clinical translation, Sep 2023, BARCELONA, Spain Poster de conférence hal-04919857v1
Imaging the 3D cellular effects of confinement in oncology: Application in pancreatic cancer Romina D’Angelo,Silvia Arcucci,Laetitia Ligat,Nicole Therville,Celine Denaiset al. Multiscale Mechanobiology of Cells and Cell Systems, France Bio-Imaging Annual Meeting, Dec 2023, Centre de Biologie Intégrative of the UT3 – Paul Sabatier, Toulouse, France. , 2023 Poster de conférence hal-04920614v1
PI3Kβ controls mechanical parameters of pancreatic tumours predictive of poor survival. Sanzhar Aitbay,Nicole Therville,Silvia Arcucci,Pauline Lefebvre,Mickael Di-Luoffoet al. EMBO | EMBL Symposium Mechanobiology in development and disease, May 2022, Heidelberg, Germany. 2022 Poster de conférence hal-04923995v1
PI3K signaling controls metabolic adaptations in pancreatic cancer Coralie Cayron,Benoît Thibault,Mickael Di-Luoffo,Nicole Therville,Camille Guyonet al. Congrès annuel du Club Français du PAncréas, Sep 2022, Paris, France Poster de conférence hal-04922329v1
PI3K signaling controls metabolic adaptations in pancreatic cancer Coralie Cayron,Benoît Thibault,Mickael Di-Luoffo,Nicole Therville,Camille Guyonet al. Abcam Cancer and Metabolism 2022, Jul 2022, Londres, United Kingdom Poster de conférence hal-04922324v1
L’impact des contraintes mécaniques compressives sur la progression et le traitement du cancer du pancréas Mickael Di-Luoffo,Pauline Lefebvre,Nicole Therville,Morgan Delarue,Julie Guillermet-Guibert Club Français du Pancréas 2021, Sep 2021, Lyon, France. 2021 Poster de conférence hal-04908669v1
MEF2 regulates Nrf2 gene expression in mouse MA-10 Leydig cells Nicholas M. Robert,Mickaël Di-Luoffo,Jacques J. Tremblay ASA 2016, Apr 2016, Nouvelle Orléans (LA), United States Poster de conférence hal-04906984v1
MEF2 and COUP-TFII cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells Mickaël Di-Luoffo,Catherine Brousseau,Raifish E. Mendoza Villarroel,Jacques J. Tremblay ASA 2015, Apr 2015, Salt lake city, UTAH, United States Poster de conférence hal-04906964v1
The transcription factor MEF2 is a novel regulator of Gsta1 expression in MA-10 Leydig cells Mickaël Di-Luoffo,Catherine Brousseau,Francis Bergeron,Jacques J. Tremblay ASA 2014, Apr 2014, Atlanta (Georgia), United States Poster de conférence hal-04906943v1
Le facteur de transcription MEF2 (Myocyte Enhancer Factor 2) : un nouveau régulateur de l'expression de Gsta1 dans les cellules de Leydig MA-10 Mickaël Di-Luoffo,Catherine Brousseau,Francis Bergeron,Jacques J. Tremblay Journée annuelle de la recherche Faculté de Médecine ULAVAL 2014, Mar 2014, Québec (Canada), Canada Poster de conférence hal-04906949v1
Rôle des facteurs de transcription MEF2 dans le maintien des fonctions stéroïdogéniques Mickael Di-Luoffo,Catherine Brousseau,Francis Bergeron,Caroline Daems,J. Tremblay Jacques Journée annuelle de la recherche Faculté de Médecine ULAVAL 2013, Jun 2013, Québec (Canada), Canada Poster de conférence hal-04906861v1
Identification of target genes for the transcription factor myocyte enhancer factor 2 in MA-10 Leydig cells Mickaël Di-Luoffo,Catherine Brousseau,Francis Bergeron,Caroline Daems,Jacques J. Tremblay SSR 2013, Jul 2013, Montréal (Canada (QC)), Canada Poster de conférence hal-04906899v1

Thèse (1)

Myocyte Enhancer Factor 2 (MEF2) : un facteur impliqué dans le maintien des fonctions stéroïdogéniques des cellules de Leydig Thèse Mickael Di-Luoffo Sciences du Vivant [q-bio]. Faculté de médecine de l'université Laval Québec, 2015. Français. ⟨NNT : ⟩ Thèse tel-04909020v1