Murat Saparbaev

Publications

Article dans une revue (54)

Deciphering the Foundations of Mitochondrial Mutational Spectra: Replication-Driven and Damage-Induced Signatures Across Chordate Classes Dmitrii Iliushchenko,Bogdan Efimenko,Alina G Mikhailova,Victor Shamanskiy,Murat K Saparbaevet al. Molecular Biology and Evolution, 2025, 42 (2), ⟨10.1093/molbev/msae261⟩ Article dans une revue hal-05350827v1
Study of the Patterns of DNA Methylation in Human Cells Through the Prism of Intra-Strand DNA Symmetry Zamart Ramazanova,Aizhan Alikul,Dinara Begimbetova,Sabira Taipakova,Bakhyt T Matkarimovet al. International Journal of Molecular Sciences, 2025, 26 (19), pp.9504. ⟨10.3390/ijms26199504⟩ Article dans une revue hal-05350805v1
Thymines opposite to bulky aristolactam-DNA adducts in duplex DNA are not targeted by human thymine-DNA glycosylase Diana Manapkyzy,Gulzhan Zhamanbayeva,Viktoriya Sidorenko,Radha Bonala,Francis Johnsonet al. PeerJ, 2025, 13, pp.e19577. ⟨10.7717/peerj.19577⟩ Article dans une revue hal-05350847v1
Role of Individual Amino Acid Residues Directly Involved in Damage Recognition in Active Demethylation by ABH2 Dioxygenase Anastasiia T Davletgildeeva,Timofey E Tyugashev,Mingxing Zhao,Alexander A Ishchenko,Murat Saparbaevet al. International Journal of Molecular Sciences, 2025, 26 (14), pp.6912. ⟨10.3390/ijms26146912⟩ Article dans une revue hal-05351193v1
An Insight into the Mechanism of DNA Cleavage by DNA Endonuclease from the Hyperthermophilic Archaeon Pyrococcus furiosus Anastasiia Davletgildeeva,Aleksandra Kuznetsova,Alexander Ishchenko,Murat Saparbaev,Nikita Kuznetsov International Journal of Molecular Sciences, 2024, Molecular Genetics and Genomics, 25 (16), pp.8897. ⟨10.3390/ijms25168897⟩ Article dans une revue hal-04795724v1
Enhanced thermal stability enables human mismatch-specific thymine–DNA glycosylase to catalyse futile DNA repair Diana Manapkyzy,Botagoz Joldybayeva,Alexander Ishchenko,Bakhyt T Matkarimov,Dmitry O Zharkovet al. PLoS ONE, 2024, 19 (10), pp.e0304818. ⟨10.1371/journal.pone.0304818⟩ Article dans une revue (data paper) hal-04794225v1
Chargaff’s second parity rule lies at the origin of additive genetic interactions in quantitative traits to make omnigenic selection possible Bakhyt T Matkarimov,Murat K Saparbaev PeerJ, 2023, 11, pp.e16671. ⟨10.7717/peerj.16671⟩ Article dans une revue hal-04425843v1
Abasic site–peptide cross-links are blocking lesions repaired by AP endonucleases Anna V Yudkina,Nikita A Bulgakov,Daria V Kim,Svetlana V Baranova,Alexander A Ishchenkoet al. Nucleic Acids Research, 2023, 51 (12), pp.6321-6336. ⟨10.1093/nar/gkad423⟩ Article dans une revue hal-04289451v1
NEIL3-mediated proteasomal degradation facilitates the repair of cisplatin-induced DNA damage in human cells Umit Aliyaskarova,Yeldar Baiken,Flore Renaud,Sophie Couve,Alexei Kisselevet al. Scientific Reports, 2023, 13 (1), pp.5174. ⟨10.1038/s41598-023-32186-3⟩ Article dans une revue hal-04289483v1
Individual Contributions of Amido Acid Residues Tyr122, Ile168, and Asp173 to the Activity and Substrate Specificity of Human DNA Dioxygenase ABH2 Anastasiia T Davletgildeeva,Timofey E Tyugashev,Mingxing Zhao,Nikita A Kuznetsov,Alexander A Ishchenkoet al. Cells, 2023, 12 (14), pp.1839. ⟨10.3390/cells12141839⟩ Article dans une revue hal-04289624v1
Pre-steady-state kinetic and mutational insights into mechanisms of endo- and exonuclease DNA processing by mutant forms of human AP endonuclease Artemiy Bakman,Alexander Ishchenko,Murat Saparbaev,Olga Fedorova,Nikita Kuznetsov Biochimica et Biophysica Acta (BBA) - General Subjects, 2022, 1866 (12), pp.130198. ⟨10.1016/j.bbagen.2022.130198⟩ Article dans une revue hal-03858673v1
Kinetic Features of 3′–5′–Exonuclease Activity of Apurinic/Apyrimidinic Endonuclease Apn2 from Saccharomyces cerevisiae Aleksandra A Kuznetsova,Anastasia A Gavrilova,Alexander A Ishchenko,Murat Saparbaev,Olga S Fedorovaet al. International Journal of Molecular Sciences, 2022, 23 (22), pp.14404. ⟨10.3390/ijms232214404⟩ Article dans une revue hal-04289790v1
Conformational Dynamics of Human ALKBH2 Dioxygenase in the Course of DNA Repair as Revealed by Stopped-Flow Fluorescence Spectroscopy Lyubov Yu. Kanazhevskaya,Denis Smyshliaev,Nadezhda Timofeyeva,Alexander Ishchenko,Murat Saparbaevet al. Molecules, 2022, 27 (15), pp.4960. ⟨10.3390/molecules27154960⟩ Article dans une revue hal-03858651v1
Comparative Analysis of Exo- and Endonuclease Activities of APE1-like Enzymes Anastasiia Davletgildeeva,Alexandra Kuznetsova,Darya Novopashina,Alexander Ishchenko,Murat Saparbaevet al. International Journal of Molecular Sciences, 2022, 23 (5), pp.2869. ⟨10.3390/ijms23052869⟩ Article dans une revue hal-03859362v1
The Kinetic Mechanism of 3′-5′ Exonucleolytic Activity of AP Endonuclease Nfo from E. coli Svetlana I Senchurova,Aleksandra A Kuznetsova,Alexander A Ishchenko,Murat Saparbaev,Olga S Fedorovaet al. Cells, 2022, 11, ⟨10.3390/cells11192998⟩ Article dans une revue hal-03858645v1
Cloning and characterization of the major AP endonuclease from Staphylococcus aureus Aigerim Turgimbayeva,Ulan Zein,Dmitry Zharkov,Yerlan Ramankulov,Murat Saparbaevet al. DNA Repair, 2022, 119, pp.103390. ⟨10.1016/j.dnarep.2022.103390⟩ Article dans une revue hal-03858686v1
Common Kinetic Mechanism of Abasic Site Recognition by Structurally Different Apurinic/Apyrimidinic Endonucleases Alexandra A Kuznetsova,Svetlana I Senchurova,Alexander Ishchenko,Murat A Saparbaev,Olga S Fedorovaet al. International Journal of Molecular Sciences, 2021, 22 (16), pp.8874. ⟨10.3390/ijms22168874⟩ Article dans une revue hal-03432659v1
Evolutionary origins of DNA repair pathways: Role of oxygen catastrophe in the emergence of DNA glycosylases Paulina Prorok,Inga R Grin,Bakhyt T Matkarimov,Alexander A Ishchenko,Jacques Lavalet al. Cells, 2021, 10 (7), pp.1591. ⟨10.3390/cells10071591⟩ Article dans une revue hal-04289943v2
Role of Base Excision Repair Pathway in the Processing of Complex DNA Damage Generated by Oxidative Stress and Anticancer Drugs Yeldar Baiken,Damira Kanayeva,Sabira Taipakova,Regina Groisman,Alexander A Ishchenkoet al. Frontiers in Cell and Developmental Biology, 2021, 8, pp.617884. ⟨10.3389/fcell.2020.617884⟩ Article dans une revue hal-03432685v1
Reading targeted DNA damage in the active demethylation pathway: role of accessory domains of eukaryotic AP endonucleases and thymine-DNA glycosylases Alexander V Popov,Inga R Grin,Antonina P Dvornikova,Bakhyt T Matkarimov,Regina Groismanet al. Journal of Molecular Biology, 2020, 432 (6), pp.1747-1768. ⟨10.1016/j.jmb.2019.12.020⟩ Article dans une revue hal-03060641v1
The Arabidopsis thaliana Poly(ADP-Ribose) Polymerases 1 and 2 Modify DNA by ADP-Ribosylating Terminal Phosphate Residues Sabira Taipakova,Aigerim Kuanbay,Christine Saint-Pierre,Didier Gasparutto,Yeldar Baikenet al. Frontiers in Cell and Developmental Biology, 2020, 8, pp.606596. ⟨10.3389/fcell.2020.606596⟩ Article dans une revue hal-03432679v1
Wheat Germination Is Dependent on Plant Target of Rapamycin Signaling Bauyrzhan Smailov,Sanzhar Alybayev,Izat Smekenov,Aibek Mursalimov,Murat A Saparbaevet al. Frontiers in Cell and Developmental Biology, 2020, 8, pp.606685. ⟨10.3389/fcell.2020.606685⟩ Article dans une revue hal-03432696v2
DNA-Histone Cross-Links: Formation and Repair Manideep C Pachva,Alexei F Kisselev,Bakhyt T Matkarimov,Murat A Saparbaev,Regina Groisman Frontiers in Cell and Developmental Biology, 2020, 8, pp.647045. ⟨10.3389/fcell.2020.607045⟩ Article dans une revue hal-03432690v1
An Assay for the Activity of Base Excision Repair Enzymes in Cellular Extracts Using Fluorescent DNA Probes O. A Kladova,D. A Iakovlev,R. Groisman,A. Ishchenko,M. K Saparbaevet al. Биохимия / Biochemistry, In press, 85 (4), pp.480-489. ⟨10.1134/S0006297920040082⟩ Article dans une revue hal-03068193v1
Mechanistic insight into the role of Poly(ADP-ribosyl)ation in DNA topology modulation and response to DNA damage Bakhyt Matkarimov,Dmitry Zharkov,Murat Saparbaev Mutagenesis, In press, 35 (1), pp.107-117. ⟨10.1093/mutage/gez045⟩ Article dans une revue hal-02392725v1
Modulation of the Apurinic/Apyrimidinic Endonuclease Activity of Human APE1 and of Its Natural Polymorphic Variants by Base Excision Repair Proteins Olga A Kladova,Irina V Alekseeva,Murat A Saparbaev,Olga S Fedorova,Nikita A Kuznetsov International Journal of Molecular Sciences, 2020, 21 (19), pp.7147. ⟨10.3390/ijms21197147⟩ Article dans une revue hal-03066830v1
Mechanism of stimulation of DNA binding of the transcription factors by human apurinic/apyrimidinic endonuclease 1, APE1 Milena Bazlekowa-Karaban,Paulina Prorok,Sonia Baconnais,Sabira Taipakova,Zhiger Akishevet al. DNA Repair, 2019, 82, pp.102698. ⟨10.1016/j.dnarep.2019.102698⟩ Article dans une revue hal-02322130v1
Aberrant repair initiated by the adenine-DNA glycosylase does not play a role in UV-induced mutagenesis in Escherichia coli Caroline Zutterling,Aibek Mursalimov,Ibtissam Talhaoui,Zhanat Koshenov,Zhiger Akishevet al. PeerJ, 2018, 6, pp.e6029. ⟨10.7717/peerj.6029⟩ Article dans une revue hal-02322261v1
Characterization of biochemical properties of an apurinic/apyrimidinic endonuclease from Helicobacter pylori Aigerim Turgimbayeva,Sailau Abeldenov,Dmitry Zharkov,Alexander Ishchenko,Yerlan Ramankulovet al. PLoS ONE, 2018, 13 (8), pp.e0202232. ⟨10.1371/journal.pone.0202232⟩ Article dans une revue hal-02322329v1
The role of the N-terminal domain of human apurinic/apyrimidinic endonuclease 1, APE1, in DNA glycosylase stimulation Olga Kladova,Milena Bazlekowa-Karaban,Sonia Baconnais,Olivier Pietrement,Alexander Ishchenkoet al. DNA Repair, 2018, 64, pp.10-25. ⟨10.1016/j.dnarep.2018.02.001⟩ Article dans une revue hal-02322373v1
Aberrant base excision repair pathway of oxidatively damaged DNA: Implications for degenerative diseases Ibtissam Talhaoui,Bakhyt Matkarimov,Thierry Tchenio,Dmitry Zharkov,Murat Saparbaev Free Radical Biology and Medicine, 2017, 107, pp.266-277. ⟨10.1016/j.freeradbiomed.2016.11.040⟩ Article dans une revue hal-02393543v1
The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure Peter Martin,Sophie Couvé,Caroline Zutterling,Mustafa Albelazi,Regina Groismanet al. Scientific Reports, 2017, 7 (1), pp.17438. ⟨10.1038/s41598-017-17693-4⟩ Article dans une revue hal-02393493v1
Pre-steady-state kinetic analysis of damage recognition by human single-strand selective monofunctional uracil-DNA glycosylase SMUG1 Alexandra Kuznetsova,Danila Iakovlev,Inna Misovets,Alexander Ishchenko,Murat Saparbaevet al. Molecular BioSystems, 2017, 13 (12), pp.2638-2649. ⟨10.1039/c7mb00457e⟩ Article dans une revue hal-02393555v1
The major Arabidopsis thaliana apurinic/apyrimidinic endonuclease, ARP is involved in the plant nucleotide incision repair pathway Zhiger Akishev,Sabira Taipakova,Botagoz Joldybayeva,Caroline Zutterling,Izat Smekenovet al. DNA Repair, 2016, 48, pp.30-42. ⟨10.1016/j.dnarep.2016.10.009⟩ Article dans une revue hal-02393578v1
TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis Emna Mahfoudhi,Ibtissam A Talhaoui,Xenia Cabagnols,Véronique Della Valle,Lise Secardinet al. DNA Repair, 2016, 43, pp.78 - 88. ⟨10.1016/j.dnarep.2016.05.031⟩ Article dans une revue pasteur-01405648v1
Structural comparison of AP endonucleases from the exonuclease III family reveals new amino acid residues in human AP endonuclease 1 that are involved in incision of damaged DNA. Modesto Redrejo-Rodríguez,Armelle Vigouroux,Aibek Mursalimov,Inga Grin,Doria Aliliet al. Biochimie, 2016, ⟨10.1016/j.biochi.2016.06.011⟩ Article dans une revue hal-01356083v1
Characterization of DNA substrate specificities of apurinic/apyrimidinic endonucleases from Mycobacterium tuberculosis Vladimir Shafirovich,Zhi Liu,Christine Saint-Pierre,Zhiger Akishev,Bakhyt Matkarimovet al. DNA Repair, 2015, 33 (23), pp.1-16. ⟨10.1016/j.dnarep.2015.05.007⟩ Article dans une revue istex hal-02393612v1
Lipid peroxidation product 4-hydroxy-2-nonenal modulates base excision repair in human cells Alicja Winczura,Alicja Czubaty,Kinga Winczura,Katarzyna Masłowska,Matylda Nałęczet al. DNA Repair, 2014, 22, pp.1-11. ⟨10.1016/j.dnarep.2014.06.002⟩ Article dans une revue hal-02393629v1
Pre-steady-state fluorescence analysis of damaged DNA transfer from human DNA glycosylases to AP endonuclease APE1 Alexandra Kuznetsova,Nikita Kuznetsov,Alexander Ishchenko,Murat Saparbaev,Olga Fedorova Biochimica et Biophysica Acta (BBA) - General Subjects, 2014, 1840 (10), pp.3042-3051. ⟨10.1016/j.bbagen.2014.07.016⟩ Article dans une revue hal-02393724v1
Step-by-step mechanism of DNA damage recognition by human 8-oxoguanine DNA glycosylase Alexandra Kuznetsova,Nikita Kuznetsov,Alexander Ishchenko,Murat Saparbaev,Olga Fedorova Biochimica et Biophysica Acta (BBA) - General Subjects, 2014, 1840 (1), pp.387-395. ⟨10.1016/j.bbagen.2013.09.035⟩ Article dans une revue hal-02393729v1
Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands Ibtissam Talhaoui,Sophie Couvé,Laurent Gros,Alexander Ishchenko,Bakhyt Matkarimovet al. Nucleic Acids Research, 2014, 42 (10), pp.6300-6313. ⟨10.1093/nar/gku246⟩ Article dans une revue hal-02393707v1
Cloning and Characterization of a Wheat Homologue of Apurinic/Apyrimidinic Endonuclease Ape1L Botagoz Joldybayeva,Paulina Prorok,Inga Grin,Dmitry Zharkov,Alexander Ishenkoet al. PLoS ONE, 2014, 9 (3), pp.e92963. ⟨10.1371/journal.pone.0092963⟩ Article dans une revue hal-02393740v1
Functional variants of human APE1 rescue the DNA repair defects of the yeast AP endonuclease/3′-diesterase-deficient strain Zhiqiang Wang,Emily Ayoub,Abdelghani Mazouzi,Inga Grin,Alexander Ishchenkoet al. DNA Repair, 2014, 22, pp.53-66. ⟨10.1016/j.dnarep.2014.07.010⟩ Article dans une revue hal-02393647v1
The mechanism of human tyrosyl-DNA phosphodiesterase 1 in the cleavage of AP site and its synthetic analogs Natalia Lebedeva,Nadejda Rechkunova,Alexander Ishchenko,Murat Saparbaev,Olga Lavrik DNA Repair, 2013, 12 (12), pp.1037-1042. ⟨10.1016/j.dnarep.2013.09.008⟩ Article dans une revue istex hal-02393777v1
Excision of 8-oxoguanine from methylated CpG dinucleotides by human 8-oxoguanine DNA glycosylase Alexandra Kuznetsova,Nikita Kuznetsov,Olga Fedorova,Rustem Kasymov,Inga Grinet al. FEBS Letters, 2013, 587 (18), pp.3129-3134. ⟨10.1016/j.febslet.2013.08.008⟩ Article dans une revue hal-02393785v1
Direct DNA Lesion Reversal and Excision Repair in Escherichia coli Sophie Couvé,Jacques Laval,Erlan Ramanculov,Olga Fedorova,Alexander Ishchenkoet al. EcoSal Plus, 2013, 5 (2), ⟨10.1128/ecosalplus.7.2.4⟩ Article dans une revue hal-02393792v1
7,8-dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases Ibtissam Talhaoui,Sophie Couvé,Alexander Ishchenko,Christophe Kunz,Primo Schäret al. Nucleic Acids Research, 2013, 41 (2), pp.912-923. ⟨10.1093/nar/gks1149⟩ Article dans une revue hal-02393748v1
Highly Mutagenic Exocyclic DNA Adducts Are Substrates for the Human Nucleotide Incision Repair Pathway Paulina Prorok,Christine Saint-Pierre,Didier Gasparutto,Olga Fedorova,Alexander Ishchenkoet al. PLoS ONE, 2012, 7 (12), pp.e51776. ⟨10.1371/journal.pone.0051776⟩ Article dans une revue hal-02368498v1
New Insights in the Removal of the Hydantoins, Oxidation Product of Pyrimidines, via the Base Excision and Nucleotide Incision Repair Pathways Modesto Redrejo-Rodríguez,Christine Saint-Pierre,Sophie Couvé,Abdelghani Mazouzi,Alexander Ishchenkoet al. PLoS ONE, 2011, 6 (7), pp.e21039. ⟨10.1371/journal.pone.0021039⟩ Article dans une revue cea-02074458v1
Crystallization and preliminary X-ray analysis of human endonuclease 1 (APE1) in complex with an oligonucleotide containing a 5,6-dihydrouracil (DHU) or an alpha-anomeric 2'-deoxyadenosine (alphadA) modified base. Pascal Retailleau,Alexander A Ishchenko,Nikita A Kuznetsov,Murat Saparbaev,Solange Moréra Acta crystallographica Section F : Structural biology communications [2014-..], 2010, 66 (Pt 7), pp.798-800. ⟨10.1107/S1744309110017021⟩ Article dans une revue hal-00512071v1
Uncoupling of the base excision and nucleotide incision repair pathways reveals their respective biological roles. Alexander A Ishchenko,Eric Deprez,Andrei V. Maksimenko,Jean-Claude Brochon,Patrick Taucet al. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 (8), pp.2564-9. ⟨10.1073/pnas.0508582103⟩ Article dans une revue hal-00216010v1
Apoptotic Topoisomerase I-DNA Complexes Induced by Staurosporine-mediated Oxygen Radicals Olivier Sordet,Qasim Khan,Isabelle Plo,Philippe Pourquier,Yoshimasa Urasakiet al. Journal of Biological Chemistry, 2004, 279 (48), pp.50499-50504. ⟨10.1074/jbc.M410277200⟩ Article dans une revue inserm-02438646v1
2'-Deoxyribonolactone lesion produces G>A transitions in Escherichia coli V. Faure,Pascal Dumy,M. Saparbaev Nucleic Acids Research, 2004, 32 (9), pp.2937-2946. ⟨10.1093/nar/gkh622⟩ Article dans une revue hal-04980658v1
The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway. Laurent Gros,Alexander A Ishchenko,Hiroshi Ide,Rhoderick H Elder,Murat K Saparbaev Nucleic Acids Research, 2004, 32 (1), pp.73-81. ⟨10.1093/nar/gkh165⟩ Article dans une revue hal-00277634v1

Chapitre d'ouvrage (3)

DNA repair and mutagenesis in vertebrate mitochondria: evidence for asymmetric DNA strand inheritance Bakhyt Matkarimov,Murat A Saparbaev Dmitry O. Zharkov. Mechanisms of genome protection and repair, 1241, Springer, pp.77-100, 2020, Advances in Experimental Medicine and Biology, 978-3-030-41282-1. ⟨10.1007/978-3-030-41283-8_6⟩ Chapitre d'ouvrage hal-03060578v1
Chapter X Alternative DNA repair pathways to handle complex DNA damage generated by oxidative stress and anticancer drugs E Matta,U Aliyaskarova,A A Kuznetsova,B T Matkarimov,O S Fedorovaet al. DNA Damage, DNA Repair and Disease, 1, Royal Society of Chemistry, 2020, Chemical Biology, 978-1-78801-889-0. ⟨10.1039/9781839160769⟩ Chapitre d'ouvrage hal-03432737v1
Alternative DNA repair pathways to handle complex DNA damage generated by oxidative stress and anticancer drugs E. Matta,U. Aliyaskarova,A. A Kuznetsova,B. T Matkarimov,O. S Fedorovaet al. Miral Dizdaroglu; R Stephen Lloyd. DNA Damage, DNA Repair and Disease, 1, Royal Society of Chemistry, pp.249-278, 2020, 978-1-78801-889-0. ⟨10.1039/9781839160769-00249⟩ Chapitre d'ouvrage hal-03301429v1