Murielle Lombard Chargée de recherche CNRS

Publications

Article dans une revue (28)

Structural Plasticity of Flavin-Dependent Thymidylate Synthase Controlled by the Enzyme Redox State Ludovic Pecqueur,Murielle Lombard,Djemel Hamdane Biomolecules, 2025, 15 (3), pp.318. ⟨10.3390/biom15030318⟩ Article dans une revue hal-05357083v1
Functional redundancy in tRNA dihydrouridylation Claudia Sudol,Lea-Marie Kilz,V. Marchand,Quentin Thullier,Vincent Guérineauet al. Nucleic Acids Research, 2024, 52 (10), pp.5880-5894. ⟨10.1093/nar/gkae325⟩ Article dans une revue hal-04614743v1
An organic O donor for biological hydroxylation reactions Katayoun Kazemzadeh Ferizhendi,Philippe Simon,Ludovic Pelosi,Emmanuel Séchet,Roache Arulanandamet al. Proceedings of the National Academy of Sciences of the United States of America, 2024, 121 (13), pp.e2321242121. ⟨10.1073/pnas.2321242121⟩ Article dans une revue pasteur-04665824v1
Evolutionary Diversity of Dus2 Enzymes Reveals Novel Structural and Functional Features among Members of the RNA Dihydrouridine Synthases Family Murielle Lombard,Colbie J Reed,Ludovic Pecqueur,Bruno Faivre,Sabrine Toubdjiet al. Biomolecules, 2022, 12 (12), pp.1760. ⟨10.3390/biom12121760⟩ Article dans une revue hal-04238858v1
Dihydrouridine in the transcriptome: New life for this ancient RNA chemical modification Damien Brégeon,Ludovic Pecqueur,Sabrine Toubdji,Claudia Sudol,Murielle Lombardet al. ACS Chemical Biology, 2022, 17 (7), pp.1638-1657. ⟨10.1021/acschembio.2c00307⟩ Article dans une revue hal-03836746v1
An enzymatic activation of formaldehyde for nucleotide methylation Charles Bou-Nader,Frederick W Stull,Ludovic Pecqueur,Philippe Simon,Vincent Guérineauet al. Nature Communications, 2021, 12, pp.4542. ⟨10.1038/s41467-021-24756-8⟩ Article dans une revue hal-03343627v1
Dihydrouridine synthesis in tRNAs is under reductive evolution in Mollicutes Bruno Faivre,Murielle Lombard,Soufyan Fakroun,Chau-Duy-Tam Vo,Catherine Goyenvalleet al. RNA Biology, 2021, 18 (12), pp.2278 - 2289. ⟨10.1080/15476286.2021.1899653⟩ Article dans une revue hal-03837152v1
Ultrafast Dynamics of Fully Reduced Flavin in Catalytic Structures of Thymidylate Synthase ThyX Nadia Dozova,Fabien Lacombat,Murielle Lombard,Djemel Hamdane,Pascal Plaza Physical Chemistry Chemical Physics, 2021, 23, pp.22692-22702. ⟨10.1039/D1CP03379D⟩ Article dans une revue hal-03361405v1
The O2-independent pathway of ubiquinone biosynthesis is essential for denitrification in Pseudomonas aeruginosa Chau-Duy-Tam Vo,Julie Michaud,Sylvie Elsen,Bruno Faivre,Emmanuelle Bouveretet al. Journal of Biological Chemistry, 2020, 295 (27), pp.9021-9032. ⟨10.1074/jbc.RA120.013748⟩ Article dans une revue pasteur-02746713v1
Ubiquinone Biosynthesis over the Entire O2 Range: Characterization of a Conserved O2-Independent Pathway Ludovic Pelosi,Chau-Duy-Tam Vo,Sophie Saphia Abby,Laurent Loiseau,Bérengère Rascalouet al. mBio, 2019, 10 (4), ⟨10.1128/mBio.01319-19⟩ Article dans une revue hal-02183791v1
Structural and Functional Characterization of 4‐Hydroxyphenylacetate 3‐Hydroxylase from Escherichia coli Yifan Deng,Bruno Faivre,Olivier Back,Murielle Lombard,Ludovic Pecqueuret al. ChemBioChem, 2019, 10 (4), ⟨10.1002/cbic.201900277⟩ Article dans une revue hal-02359262v1
A Soluble Metabolon Synthesizes the Isoprenoid Lipid Ubiquinone Mahmoud Hajj Chehade,Ludovic Pelosi,Cameron David Fyfe,Laurent Loiseau,Bérengère Rascalouet al. Cell Chemical Biology, 2019, 26 (4), pp.482-492.e7. ⟨10.1016/j.chembiol.2018.12.001⟩ Article dans une revue hal-02071798v1
Power of protein/tRNA functional assembly against aberrant aggregation Charles Bou-Nader,Ludovic Pecqueur,David Cornu,Murielle Lombard,Manuela Deziet al. Physical Chemistry Chemical Physics, 2017, ⟨10.1039/c7cp05599d⟩ Article dans une revue hal-02187768v1
Flavin-dependent epitranscriptomic world Murielle Lombard,Djemel Hamdane Archives of Biochemistry and Biophysics, 2017, ⟨10.1016/j.abb.2017.06.011⟩ Article dans une revue hal-01542856v1
The UbiK protein is an accessory factor necessary for bacterial ubiquinone (UQ) biosynthesis and forms a complex with the UQ biogenesis factor UbiJ Laurent Loiseau,Cameron Fyfe,Laurent Aussel,Mahmoud Hajj Chehade,Sara B. Hernándezet al. Journal of Biological Chemistry, 2017, 292 (28), pp.11937 - 11950. ⟨10.1074/jbc.M117.789164⟩ Article dans une revue hal-01615493v1
A chemical chaperone induces inhomogeneous conformational changes in flexible proteins Djemel Hamdane,Christophe Velours,David Cornu,Magali Nicaise,Murielle Lombardet al. Physical Chemistry Chemical Physics, 2016, 18 (30), pp.20410--20421. ⟨10.1039/c6cp03635j⟩ Article dans une revue hal-02393836v1
Coenzyme Q Biosynthesis: Evidence for a Substrate Access Channel in the FAD-Dependent Monooxygenase Coq6 Alexandre Ismail,Vincent Leroux,Myriam Smadja,Lucie Gonzalez,Murielle Lombardet al. PLoS Computational Biology, 2016, 12 (1), pp.e1004690. ⟨10.1371/journal.pcbi.1004690⟩ Article dans une revue hal-01424489v1
Expression in yeast, new substrates, and construction of a first 3D model of human orphan cytochrome P450 2U1: Interpretation of substrate hydroxylation regioselectivity from docking studies. Lionel Ducassou,Gabriella Jonasson,Laura Dhers,Nicolas Pietrancosta,Booma Ramassamyet al. BBA - Biochimica et Biophysica Acta, 2015, 1850 (7), pp.1426-37. ⟨10.1016/j.bbagen.2015.03.014⟩ Article dans une revue hal-01449701v1
Biosynthesis and physiology of coenzyme Q in bacteria. Laurent Aussel,Fabien Pierrel,Laurent Loiseau,Murielle Lombard,Marc Fontecaveet al. Biochimica biophysica acta (BBA) - Bioenergetics, 2014, 1837 (7), pp.1004-1011. ⟨10.1016/j.bbabio.2014.01.015⟩ Article dans une revue hal-01077983v1
A new gene involved in coenzyme Q biosynthesis in Escherichia coli: UbiI functions in aerobic C5-hydroxylation Mahmoud Hajj Chehade,Laurent Loiseau,Murielle Lombard,Ludovic Pecqueur,Alexandre Ismailet al. Journal of Biological Chemistry, 2013, 288 (27), pp.20085-92. ⟨10.1074/jbc.M113.480368⟩ Article dans une revue hal-00904907v1
Intermolecular electron transfer in two-iron superoxide reductase: a putative role for the desulforedoxin center as an electron donor to the iron active site. Florence Bonnot,Simon Duval,Murielle Lombard,Julien Valton,Chantal Houée-Levinet al. Journal of Biological Inorganic Chemistry, 2011, 16 (6), pp.889-98. ⟨10.1007/s00775-011-0788-5⟩ Article dans une revue hal-01075287v1
Superoxide reductase from Desulfoarculus baarsii: identification of protonation steps in the enzymatic mechanism. Vincent Nivière,Marcel Asso,Claire O Weill,Murielle Lombard,Bruno Guigliarelliet al. Biochemistry, 2004, 43, pp.808-18. ⟨10.1021/bi035698i⟩ Article dans une revue hal-01075794v1
Identification of iron(III) peroxo species in the active site of the superoxide reductase SOR from Desulfoarculus baarsii. Christelle Mathé,Tony A Mattioli,Olivier Horner,Murielle Lombard,Jean-Marc Latouret al. Journal of the American Chemical Society, 2002, pp.4966-7 Article dans une revue hal-01075797v1
Superoxide reductase from Desulfoarculus baarsii. Vincent Nivière,Murielle Lombard Methods in Enzymology, 2001, 349, pp.123-9 Article dans une revue hal-01075799v1
Pulse radiolysis studies on superoxide reductase from Treponema pallidum. V Nivière,M Lombard,M. Fontecave,C Houée-Levin FEBS Letters, 2001, 497, pp.171-3. ⟨10.1016/S0014-5793(01)02468-1⟩ Article dans une revue hal-01075800v1
Superoxide reductase from Desulfoarculus baarsii: reaction mechanism and role of glutamate 47 and lysine 48 in catalysis. M Lombard,C Houée-Levin,D Touati,M. Fontecave,V Nivière Biochemistry, 2001, pp.5032-40 Article dans une revue hal-01075802v1
Reaction of the desulfoferrodoxin from Desulfoarculus baarsii with superoxide anion. Evidence for a superoxide reductase activity. M Lombard,M. Fontecave,D Touati,V Nivière Journal of Biological Chemistry, 2000, 275, pp.115-21. ⟨10.1074/jbc.275.1.115⟩ Article dans une revue hal-01075803v1
Superoxide reductase as a unique defense system against superoxide stress in the microaerophile Treponema pallidum. M Lombard,D Touati,M. Fontecave,V Nivière Journal of Biological Chemistry, 2000, 275 (35), pp.27021-6 Article dans une revue hal-01075805v1

Communication dans un congrès (1)

Anaerobic ubiquinone biosynthetic pathway in Escherichia coli Katayoun Kazemzadeh,Sophie Abby,Sophie-Carole Chobert,Mahmoud Hajj Chehade,M Lombardet al. Société française de biochimie et biologie moléculaire, Jul 2022, Paris, France Communication dans un congrès hal-04976976v1