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Nadine Millot



**Until 2007**: The originality of the approach I have undertaken to synthesize and study nanomaterials was to jointly control the morphology, the size distribution, the nature of the interfaces and the stoichiometry of the products. Indeed, many controversies in literature come from the non-control of one of these parameters (evolution of the lattice parameters, phase transition temperatures…). Some of these controversies have thus been excluded thanks to the approach I have developed. **After 2007** (after my habilitation): I refocused my work to initiate, in my laboratory, a new thematic about bioapplications of nanopowders. **Founder of the Research Team** [(Bio-)hybrid nanoparticles & nanostructures BH2N]( The key nanomaterials studied are: - SPIONs (SuperParamagnetic Iron Oxide Nanoparticles) for multimodal imaging (MRI/PET and MRI/optical imaging). Two strengths are put to use (i) the originality of their simultaneous synthesis and colloidal stabilization in one step through a hydrothermal synthesis device working continuously (synthesis time <10 s, conditions T, P up to the supercritical water field) and (ii) the association of these nanoparticles with innovative chelating agents (NODAGA, MANOTA etc.) or innovative fluorophores (phtalocyanine in particular). - Titanate nanotubes (TiONts) that few teams in the world are able to synthesize. For the first time, these nanoparticles are developed for applications related to their ability to be internalized in various cell types. They have proven themselves for DNA transfection and radiosensitizing of tumors (glioblastoma and prostate cancer).


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A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

Ankur Sood , Margaux Desseigne , Atul Dev , Lionel Maurizi , Anuj Kumar et al.
Journal articles hal-03921672v1
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Titanate nanoribbon-based nanobiohybrid for potential applications in regenerative medicine

Lionel Maurizi , Vanessa Bellat , Mathieu Moreau , Emmanuel de Maistre , Julien Boudon et al.
RSC Advances, 2022, 12 (41), pp.26875-26881. ⟨10.1039/D2RA04753E⟩
Journal articles hal-03782926v1
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Mechanosynthesis of carbonate and lithium co-substituted hydroxyfluorapatite

Hanen Hajji , Sophie Le Gallet , Lucien Saviot , Ezzedine Ben Salem , Nadine Millot et al.
Materials Research Bulletin, 2022, 150, pp.111750. ⟨10.1016/j.materresbull.2022.111750⟩
Journal articles hal-03548824v1

Size effect and mucus role on the intestinal toxicity of the E551 food additive and engineered silica nanoparticles

Taghrid Zaiter , Raphaël Cornu , Nadine Millot , Michaële Herbst , Yann Pellequer et al.
Nanotoxicology, 2022, pp.1-18. ⟨10.1080/17435390.2022.2063084⟩
Journal articles hal-03683083v1

Use of Super Paramagnetic Iron Oxide Nanoparticles as Drug Carriers in Brain and Ear: State of the Art and Challenges

Caroline Guigou , Nadine Millot , Karim Belharet , Alexis Bozorg Grayeli , Kibrom Berihu Girum et al.
IEEE Transactions on Medical Imaging, 2021, 40 (6), pp.1542-1554. ⟨10.3390/brainsci11030358⟩
Journal articles hal-03270803v1
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In vivo protein corona on nanoparticles: does the control of all material parameters orient the biological behavior?

Nimisha Singh , Célia Marets , Julien Boudon , Nadine Millot , Lucien Saviot et al.
Nanoscale Advances, 2021, ⟨10.1039/D0NA00863J⟩
Journal articles hal-03132542v1
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Cu-Doped ZnO Nanoparticles for Non-Enzymatic Glucose Sensing

Amira Mahmoud , Mosaab Echabaane , Karim Omri , Julien Boudon , Lucien Saviot et al.
Molecules, 2021, 26 (4), pp.929. ⟨10.3390/molecules26040929⟩
Journal articles hal-03321414v1
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Anti‐Platelet Effect Induced by Iron Oxide Nanoparticles: Correlation with Conformational Change in Fibrinogen

Regina Komal Kottana , Lionel Maurizi , Brian Schnoor , Kenise Morris , Jessica Ann Webb et al.
Small, 2021, 17 (1), pp.2004945. ⟨10.1002/smll.202004945⟩
Journal articles hal-03052354v1

In vivo protein corona on nanoparticles: does the control of all material parameters orient the biological behavior? (Inside front cover)

Nimisha Singh , Célia Marets , Julien Boudon , Nadine Millot , Lucien Saviot et al.
Nanoscale Advances, 2021, 3 (5), pp.1156-1156. ⟨10.1039/D1NA90021H⟩
Journal articles hal-03793275v1
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Kinematic modelisation and parametric study of mechanosynthesis of hydroxyfluorapatite

Hanen Hajji , Mohieddine Abdellaoui , Lionel Maurizi , Samia Nasr , Nadine Millot et al.
Advanced Powder Technology, 2021, 32 (10), pp.3585-3600. ⟨10.1016/j.apt.2021.08.013⟩
Journal articles hal-03323626v1
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About the Influence of PEG Spacers on the Cytotoxicity of Titanate Nanotubes-Docetaxel Nanohybrids against a Prostate Cancer Cell Line

Alexis Loiseau , Julien Boudon , Céline Mirjolet , Véronique Morgand , Nadine Millot et al.
Nanomaterials, 2021, 11 (10), pp.2733. ⟨10.3390/nano11102733⟩
Journal articles hal-03793181v1
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Taurine-Conjugated Mussel-Inspired Iron Oxide Nanoparticles with an Elongated Shape for Effective Delivery of Doxorubicin into the Tumor Cells

Nimisha Singh , Nadine Millot , Lionel Maurizi , Gérard Lizard , Rajender Kumar et al.
ACS Omega, 2020, 5 (26), pp.16165-16175. ⟨10.1021/acsomega.0c01747⟩
Journal articles hal-02902885v1
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Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging

Guillaume Thomas , Julien Boudon , Lionel Maurizi , Mathieu Moreau , Paul Walker et al.
ACS Omega, 2019, 4 (2), pp.2637-2648. ⟨10.1021/acsomega.8b03283⟩
Journal articles hal-02068644v1
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Efficient Quantification by X-ray Photoelectron Spectroscopy and Thermogravimetric Analyses of the One-Pot Grafting of Two Molecules on the Surface of Iron Oxide Nanoparticles

Lionel Maurizi , Fadoua Sallem , Julien Boudon , Olivier Heintz , Harender Bisht et al.
Journal of Nanoscience and Nanotechnology, 2019, 19 (8), pp.4920-4929. ⟨10.1166/jnn.2019.16796⟩
Journal articles hal-02163532v1

Superparamagnetic Nanoparticle Delivery to the Cochlea Through Round Window by External Magnetic Field: Feasibility and Toxicity

Gaëlle Leterme , Caroline Guigou , Alexandra Oudot , Bertrand Collin , Julien Boudon et al.
Surgical Innovation, 2019, pp.155335061986721. ⟨10.1177/1553350619867217⟩
Journal articles hal-02342085v1
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Titanate Nanotubes Engineered with Gold Nanoparticles and Docetaxel to Enhance Radiotherapy on Xenografted Prostate Tumors

Alexis Loiseau , Julien Boudon , Alexandra Oudot , Mathieu Moreau , Romain Boidot et al.
Cancers, 2019, 11 (12), pp.1962. ⟨10.3390/cancers11121962⟩
Journal articles hal-02735286v1
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Elaboration of Trans-Resveratrol Derivative-Loaded Superparamagnetic Iron Oxide Nanoparticles for Glioma Treatment

Fadoua Sallem , Rihab Haji , Dominique Vervandier-Fasseur , Thomas Nury , Lionel Maurizi et al.
Nanomaterials, 2019, 9 (2), pp.287. ⟨10.3390/nano9020287⟩
Journal articles hal-02163534v1
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Cellular interactions of functionalized superparamagnetic iron oxide nanoparticles on oligodendrocytes without detrimental side effects: Cell death induction, oxidative stress and inflammation

S. Sruthi , Lionel Maurizi , T. Nury , F. Sallem , J. Boudon et al.
Colloids and Surfaces B: Biointerfaces, 2018, 170, pp.454-462. ⟨10.1016/j.colsurfb.2018.06.041⟩
Journal articles hal-02163524v1
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In vitro interaction and biocompatibility of titanate nanotubes with microglial cells

S. Sruthi , A. Loiseau , J. Boudon , F. Sallem , Lionel Maurizi et al.
Toxicology and Applied Pharmacology, 2018, 353, pp.74-86. ⟨10.1016/j.taap.2018.06.013⟩
Journal articles hal-02163529v1

Taxane-Grafted Metal-Oxide Nanoparticles as a New Theranostic Tool against Cancer: The Promising Example of Docetaxel-Functionalized Titanate Nanotubes on Prostate Tumors

Alexis Loiseau , Julien Boudon , Céline Mirjolet , Gilles Créhange , Nadine Millot et al.
Advanced Healthcare Materials, 2017, ⟨10.1002/adhm.201700245⟩
Journal articles hal-01553114v1

Docetaxel-titanate nanotubes enhance radiosensitivity in an androgen-independent prostate cancer model

Céline Mirjolet , Julien Boudon , Alexis Loiseau , Sandy Chevrier , Romain Boidot et al.
International Journal of Nanomedicine, 2017, 12, pp.6357 - 6364. ⟨10.2147/IJN.S139167⟩
Journal articles hal-01614449v1

Synthesis and characterization of chitosan-coated titanate nanotubes: towards a new safe nanocarrier

Fadoua Sallem , Julien Boudon , Olivier Heintz , Isabelle Séverin , Adel Megriche et al.
Dalton Transactions, 2017, 46, pp.15386-15398. ⟨10.1039/c7dt03029k⟩
Journal articles hal-01625668v1

Efficient functionalization of magnetite nanoparticles with phosphonate using a one-step continuous hydrothermal process

Guillaume Thomas , Frédéric Demoisson , Julien Boudon , Nadine Millot
Dalton Transactions, 2016, 45 (26), pp.10821 - 10829. ⟨10.1039/C6DT01050D⟩
Journal articles hal-01698664v1

Preclinical development of a docetaxel nanocarrier to enhance prostate cancer radiosensitivity.

Gilles Crehange , Julien Boudon , Romain Boidot , Sandy Chevrier , Cecile Dalban et al.
Journal of Clinical Oncology, 2015, 33 (7_suppl), pp.41. ⟨10.1200/jco.2015.33.7_suppl.41⟩
Journal articles hal-03793096v1
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Influence of Surface Charge and Polymer Coating on Internalization and Biodistribution of Polyethylene Glycol-Modified Iron Oxide Nanoparticles

Lionel Maurizi , Anne-Laure Papa , Laure Dumont , Frédéric Bouyer , Paul Walker et al.
Journal of Biomedical Nanotechnology, 2015, 11 (1), pp.126-136. ⟨10.1166/jbn.2015.1996⟩
Journal articles hal-02163365v1
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Dispersion of titanate nanotubes for nanomedicine: comparison of PEI and PEG nanohybrids

Anne-Laure Papa , Julien Boudon , Vanessa Bellat , Alexis Loiseau , Harender Bisht et al.
Dalton Transactions, 2015, 44 (2), pp.739-746. ⟨10.1039/C4DT02552K⟩
Journal articles hal-03793107v1
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Phthalocyanine–titanate nanotubes: a promising nanocarrier detectable by optical imaging in the so-called imaging window

Jérémy Paris , Yann Bernhard , Julien Boudon , Olivier Heintz , Nadine Millot et al.
RSC Advances, 2014, 5 (9), pp.6315-6322. ⟨10.1039/c4ra13988g⟩
Journal articles hal-03263264v1

The enhancement of radiotherapy efficacy with docetaxel-titanate nanotubes as a new nanohybrid for localized high risk prostate cancer

Céline Mirjolet , Julien Boudon , Alexis Loiseau , Sandy Chevrier , Thomas Gautier et al.
European Journal of Cancer, 2014, 50 (6), pp.67. ⟨10.1016/S0959-8049(14)70333-8⟩
Journal articles hal-03793079v1

Immobilized Pd on magnetic nanoparticles bearing proline as a highly efficient and retrievable Suzuki–Miyaura catalyst in aqueous media

E. Nehlig , B. Waggeh , N. Millot , Y. Lalatonne , L. Motte et al.
Dalton Transactions, 2014, 44 (2), pp.2015 Jan 14;44(2):501-5. ⟨10.1039/c4dt02899f⟩
Journal articles hal-01113619v1
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Fast and continuous synthesis of nanostructured iron spinel in supercritical water: influence of cations and citrates

Lionel Maurizi , F. Bouyer , M. Ariane , R. Chassagnon , N. Millot et al.
RSC Advances, 2014, 4 (86), pp.45673-45678. ⟨10.1039/C4RA08562K⟩
Journal articles hal-02163438v1

Magneto-optical nanomaterials: a SPIO–phthalocyanine scaffold built step-by-step towards bimodal imaging

Julien Boudon , Jérémy Paris , Yann Bernhard , Elena Popova , Richard Decréau et al.
Chemical Communications, 2013, 49 (67), pp.7394. ⟨10.1039/c3cc41898g⟩
Journal articles hal-03262936v1

The Radiosensitization Effect of Titanate Nanotubes as a Promising Tool in Radiotherapy: A Proof-of-Concept

Céline Mirjolet , Anne-Laure Papa , Gilles Créhange , Julien Boudon , Olivier Raguin et al.
Radiotherapy & Oncology, 2012, 104, pp.24. ⟨10.1016/S0167-8140(15)34565-5⟩
Journal articles hal-03792958v1

Deposition and characterization of cold sprayed nanocrystalline NiTi

S. Tria , O. Elkedim , R. Hamzaoui , X. Guo , F. F. Bernard et al.
Powder Technology, 2011, 210 (2), pp.181 - 188. ⟨10.1016/j.powtec.2011.02.026⟩
Journal articles hal-01620669v1
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One step continuous hydrothermal synthesis of very fine stabilized superparamagnetic nanoparticles of magnetite

Lionel Maurizi , Frédéric Bouyer , Jérémy Paris , Frédéric Demoisson , Lucien Saviot et al.
Chemical Communications, 2011, 47, pp.11706. ⟨10.1039/C1CC15470B⟩
Journal articles hal-00638205v1
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Synthesis of Titanate Nanotubes Directly Coated with USPIO in Hydrothermal Conditions: A New Detectable Nanocarrier

Anne-Laure Papa , Lionel Maurizi , David Vandroux , Paul Walker , N. Millot et al.
Journal of Physical Chemistry C, 2011, 115 (39), pp.19012-19017. ⟨10.1021/jp2056893⟩
Journal articles hal-00785179v1

Synthesis and characterization of nanometric powders of UO2+x, (Th,U)O2+x and (La,U)O2+x

G. Rousseau , M. Fattahi , Bernd Grambow , L. Desgranges , Florent Boucher et al.
Journal of Solid State Chemistry, 2009, 182 (10), pp.2591. ⟨10.1016/j.jssc.2009.06.039⟩
Journal articles hal-00432849v1
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Easy Route to Functionalize Iron Oxide Nanoparticles via Long-Term Stable Thiol Groups

L Maurizi , H Bisht , Frédéric Bouyer , Nadine Millot
Langmuir, 2009, 25 (16), pp.8857-8859. ⟨10.1021/la901602w⟩
Journal articles hal-00447491v1

Effect of Reaction Parameters on Composition and Morphology of Titanate Nanomaterials

Anne-Laure Papa , Nadine Millot , Lucien Saviot , Rémi Chassagnon , Olivier Heintz et al.
Journal of Physical Chemistry C, 2009, 113 (29), pp.12682-12689. ⟨10.1021/jp903195h⟩
Journal articles hal-00404290v1
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On the origin of the sigmoid shape in the UO2 oxidation weight gain curves

Ludovic Quémard , Lionel Desgranges , Vincent Bouineau , Michèle Pijolat , G. Baldinozzi et al.
Journal of the European Ceramic Society, 2009, 29 (13), pp.2791-2798. ⟨10.1016/j.jeurceramsoc.2009.04.010⟩
Journal articles hal-00439251v2

Inelastic neutron scattering due to acoustic vibrations confined in nanoparticles: theory and experiment

Lucien Saviot , Caleb H. Netting , Daniel B. Murray , Stéphane Rols , Alain Mermet et al.
Physical Review B: Condensed Matter and Materials Physics (1998-2015), 2008, 78, pp.245426. ⟨10.1103/PhysRevB.78.245426⟩
Journal articles hal-00394360v1

Temperature dependent photoluminescence of photocatalytically active titania nanopowders

H. Bieber , P. Gilliot , M. Gallart , N. Keller , V. Keller et al.
Catalysis Today, 2007, 122, pp.101-108. ⟨10.1016/j.cattod.2007.01.036⟩
Journal articles hal-00212091v1

Spark plasma sintering of cobalt ferrite nanopowders prepared by coprecipitation and hydrothermal synthesis.

N. Millot , S. Le Gallet , D. Aymes , F. Bernard , Y. Grin et al.
Journal of the European Ceramic Society, 2007, 27, pp.921-926. ⟨10.1016/j.jeurceramsoc.2006.04.141⟩
Journal articles hal-00116595v1

Continuous hydrothermal synthesis of nanometric BaZrO3 in supercritical water

Daniel Aymes , Baowei B. Xin , Anne Aimable , Nadine Millot
Journal of Solid State Chemistry, 2007, 181, pp.183-189. ⟨10.1016/j.jssc.2007.11.015⟩
Journal articles hal-00400376v1

In situ and time resolved study of the g/a-Fe2O3 transition in nanometric particles.

T. Belin , N. Millot , N. Bovet , Marc Gailhanou
Journal of Solid State Chemistry, 2007, 180 (8), pp.2377
Journal articles hal-00312812v1

Low-frequency Raman characterization of size-controlled anatase TiO2 nanopowders prepared by continuous hydrothermal syntheses

Catherine Pighini , Daniel Aymes , Nadine Millot , Lucien Saviot
Journal of Nanoparticle Research, 2007, 9, pp.309. ⟨10.1007/s11051-005-9061-6⟩
Journal articles hal-00136053v1

Far infrared absorption by acoustic phonons in titanium dioxide nanopowders

Daniel B. Murray , Caleb H. Netting , Lucien Saviot , Catherine Pighini , Nadine Millot et al.
Journal of Nanoelectronics and Optoelectronics, 2006, 1, pp.92. ⟨10.1166/jno.2006.010⟩
Journal articles hal-00094084v1

A detailed study of UO2 to U3O8 oxidation phases and the associated rate-limiting steps

G. Rousseau , L. Desgranges , F. Charlot , N. Millot , Jc Niepce et al.
Journal of Nuclear Materials, 2006, 355 (1-3), pp.10-20. ⟨10.1016/j.jnucmat.2006.03.015⟩
Journal articles hal-00115276v1

Surface adsorption effects on the lattice expansion of copper nanocrystals

Y. Champion , F. Bernard , Nadine Millot , Pascal Perriat
Applied Physics Letters, 2005, pp.1-3
Journal articles hal-00436774v1

Control of grain size and morphologies of nanograined ferrites by adaptation of the synthesis route. Mechanosynthesis and soft chemistry

N. Guigue-Millot , Sylvie Begin-Colin , Y. Champion , Martin Hÿtch , Gérard Le Caër et al.
Journal of Solid State Chemistry, 2003, pp.30-38
Journal articles hal-00475138v1

Sintering of copper nanopowders under hydrogen: an in situ X-ray diffraction analysis.

Y. Champion , F. Bernard , N. Guigue-Millot , Pascal Perriat
Materials Science & Engineering, AStructural Materials: Properties, Microstructure and Processing, 2003, pp.258-263
Journal articles hal-00475132v1

Particle Size Dependency of Ternary Diagrams at the Nanometer Scale: Evidence of TiO2 Clusters in Fe-Based Spinels

Nadine Millot , D. Aymes , F. Bernard , J.C. Niepce , A. Traverse et al.
Journal of Physical Chemistry B, 2003, pp.5740-5750
Journal articles hal-00475136v1

Apparent magic numbers in embedded Ti-O clusters

N. Guigue-Millot , Olivier Tillement , Pascal Perriat
Physical Review B: Condensed Matter and Materials Physics (1998-2015), 2003, pp.1-4
Journal articles hal-00475155v1

Segregation phenomena in nanometric titanium ferrites: Complementarity of different experimental techniques (DRX, XPS, EXAFS...)

N. Guigue-Millot , F. Bernard , J.C. Niepce , A. Traverse , Pascal Perriat et al.
Journal de Physique IV Proceedings, 2002, pp.473-479
Journal articles hal-00475483v1

Chemical heterogeneities in nanometric titanomagnetites prepared by soft chemistry and studied ex situ : evidence for fe-segregation and oxidation kinetics

N. Guigue-Millot , Y. Champion , Martin Hÿtch , F. Bernard , Sylvie Begin-Colin et al.
Journal of Physical Chemistry B, 2001, pp.7125-7132
Journal articles hal-00475337v1

HIV-1 subtyping using phylogenetic analysis of pol gene sequences.

C. Pasquier , N. Millot , R. Njouom , K. Sandres , M. Cazabat et al.
Journal of Virological Methods, 2001, 94 (1-2), pp.45-54. ⟨10.1016/S0166-0934(01)00272-5⟩
Journal articles hal-00542209v1

Evidence for the verwey transition in highly nonstoichiometric nanometric fe-based ferrites

N. Guigue-Millot , N. Keller , Pascal Perriat
Physical Review B: Condensed Matter and Materials Physics (1998-2015), 2001, pp.24-26
Journal articles hal-00475328v1
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Correlation Between the Reactivity Towards Oxygen and the Coercitivity in Submicron Vanadium Ferrite Spinels

V. Nivoix , B. Gillot , D. Aymes , P. Perriat , N. Millot et al.
Journal de Physique IV Proceedings, 1997, 07 (C1), pp.C1-237-C1-238. ⟨10.1051/jp4:1997190⟩
Journal articles jpa-00255137v1
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In vitro hazard assessment of nanoparticles developed for biomedical applications

Annette Luce , Y Saibi , Isabelle Séverin , Julien Boudon , Nadine Millot et al.
European Society of Toxicology In Vitro (ESTIV) 2016 meeting, Oct 2016, Juan-les-Pins, France. 2016
Conference poster hal-01986190v1
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Development of Novel Versatile Theranostic Platforms Based on Titanate Nanotubes: Towards Safe Nanocarriers for Biomedical Applications

Julien Boudon , Fadoua Sallem , Alexis Loiseau , Lionel Maurizi , Anne-Laure Papa et al.
New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications, Springer International Publishing, pp.151-178, 2021, ⟨10.1007/978-3-030-57456-7_8⟩
Book sections hal-03276177v1
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Toxicological Risk Assessment of Emerging Nanomaterials: Cytotoxicity, Cellular Uptake, Effects on Biogenesis and Cell Organelle Activity, Acute Toxicity and Biodistribution of Oxide Nanoparticles

Lionel Maurizi , Anne-Laure Papa , Julien Boudon , Sruthi Sudhakaran , Benoist Pruvot et al.
Unraveling the Safety Profile of Nanoscale Particles and Materials-From Biomedical to Environmental Applications, InTech, 2018, ⟨10.5772/intechopen.71833⟩
Book sections hal-02163546v1

Titanate Nanotubes as a Versatile Platform for Nanomedicine

Julien Boudon , Anne-Laure Papa , Jérémy Paris , Nadine Millot
One Central Press (OCP); Alexander Seifalian; Achala de Mel; Deepak M. Kalaskar. Nanomedicine, Chapter 26, , pp.403-428, 2014, 978-1-910086-01-8 (eBook-PDF); 978-1-910086-00-1 (Hardback). ⟨10.13140/2.1.2892.7045⟩
Book sections hal-03793057v1