Natalia de Isla

Publications

Article dans une revue (38)

Optimized GMP-grade Wharton’s jelly’s mesenchymal stromal cells manufacturing and administration protocol for Graft versus Host disease prevention Cécile Pochon,Romain Perouf,Anne-Béatrice Notarantonio,Allan Bertrand,Naceur Charifet al. Current Research in Translational Medicine, 2025, 73 (4), pp.103543. ⟨10.1016/j.retram.2025.103543⟩ Article dans une revue hal-05496220v1
Experimental study of transient particle suspension in bioreactors using a light attenuation technique Charlotte Maillot,Angélique Delafosse,Natalia de Isla,Eric Olmos,Dominique Toye Chemical Engineering Science, 2024, 285, pp.119633. ⟨10.1016/j.ces.2023.119633⟩ Article dans une revue hal-04616428v1
Highly immunosuppressive myeloid cells correlate with early relapse after allogeneic stem cell transplantation Anne-Béatrice Notarantonio,Allan Bertrand,Romain Piucco,Ghislain Fievet,Hervé Sarteletet al. Experimental Hematology & Oncology, 2024, 13 (1), pp.50. ⟨10.1186/s40164-024-00516-4⟩ Article dans une revue hal-04576863v1
Scale-Up of Academic Mesenchymal Stromal Cell Production Caroline Laroye,Mélanie Gauthier,Jessica Morello,Naceur Charif,Véronique Latger-Cannardet al. Journal of Clinical Medicine, 2023, 12 (13), pp.4414. ⟨10.3390/jcm12134414⟩ Article dans une revue hal-04503576v1
Secretome of Mesenchymal Stem Cells from Consecutive Hypoxic Cultures Promotes Resolution of Lung Inflammation by Reprogramming Anti-Inflammatory Macrophages Zhihong Xu,Lulu Lin,Yuxuan Fan,Céline Huselstein,Natalia de Islaet al. International Journal of Molecular Sciences, 2022, 23 (8), pp.4333. ⟨10.3390/ijms23084333⟩ Article dans une revue hal-04504687v1
Impact of microcarrier concentration on mesenchymal stem cell growth and death: Experiments and modeling Charlotte Maillot,Natalia De Isla,Celine Loubiere,Dominique Toye,Eric Olmos Biotechnology and Bioengineering, 2022, 119 (12), pp.3537 - 3548. ⟨10.1002/bit.28228⟩ Article dans une revue hal-04504478v1
Quality by design to define critical process parameters for mesenchymal stem cell expansion Charlotte Maillot,Caroline Sion,Natalia de Isla,Dominique Toye,Eric Olmos Biotechnology Advances, 2021, 50, pp.107765. ⟨10.1016/j.biotechadv.2021.107765⟩ Article dans une revue hal-03505285v1
Characterization of Bone Marrow and Wharton’s Jelly Mesenchymal Stromal Cells Response on Multilayer Braided Silk and Silk/PLCL Scaffolds for Ligament Tissue Engineering Xing Liu,Adrien Baldit,Emilie de Brosses,Frédéric Velard,Ghislaine Cauchoiset al. Polymers, 2020, 12 (9), pp.2163. ⟨10.3390/polym12092163⟩ Article dans une revue hal-02973729v1
Impact of the type of microcarrier and agitation modes on the expansion performances of mesenchymal stem cells derived from umbilical cord Céline Loubière,Caroline Sion,Natalia de Isla,Loïc Reppel,Emmanuel Guedonet al. Biotechnology Progress, 2019, 35 (6), pp.e2887. ⟨10.1002/btpr.2887⟩ Article dans une revue hal-02968491v1
Mesenchymal stem cell interacted with PLCL braided scaffold coated with poly- l -lysine/hyaluronic acid for ligament tissue engineering Xing Liu,Cédric Laurent,Qiaoyue Du,Laurie Targa,Ghislaine Cauchoiset al. Journal of Biomedical Materials Research Part A, 2018, 106 (12), pp.3042-3052. ⟨10.1002/jbm.a.36494⟩ Article dans une revue hal-02070806v1
Defining a scaffold for ligament tissue engineering: What has been done, and what still needs to be done Cédric P. Laurent,Xing Liu,Natalia de Isla,Xiong Wang,Rachid Rahouadj Journal of Cellular Immunotherapy, 2018, 4 (1), pp.4-9. ⟨10.1016/j.jocit.2018.09.002⟩ Article dans une revue hal-02070833v1
Laser photobiomodulation in pressure ulcer healing of human diabetic patients: gene expression analysis of inflammatory biochemical markers Anelice Calixto Ruh,Lucio Frigo,Marcos Fernando Xisto Braga Cavalcanti,Paulo Svidnicki,Viviane Nogaroto Vicariet al. Lasers in Medical Science, 2018, 33 (1), pp.165 - 171. ⟨10.1007/s10103-017-2384-6⟩ Article dans une revue hal-01831939v1
Influence of mechanical forces on bone: Introduction to mechanobiology and mechanical adaptation concept Jean-François Stoltz,Jacques Magdalou,Daniel George,Yun Chen,Yinping Liet al. Journal of Cellular Immunotherapy, 2018, 4 (1), pp.10 - 12. ⟨10.1016/j.jocit.2018.09.003⟩ Article dans une revue hal-05475490v1
Stem cells and vascular regenerative medicine: A mini review Jean-François Stoltz,Danièle Bensoussan,Natalia de Isla,L. Zhang,Z. Hanet al. Clinical Hemorheology and Microcirculation, 2017, 64 (4), pp.613 - 633. ⟨10.3233/CH-168036⟩ Article dans une revue hal-01715476v1
Revisiting MSC expansion from critical quality attributes to critical culture process parameters Céline Martin,Eric Olmos,Marie-Laure Collignon,Natalia de Isla,Fabrice Blanchardet al. Process Biochemistry, 2017, 59, pp.231 - 243. ⟨10.1016/j.procbio.2016.04.017⟩ Article dans une revue hal-01921144v1
MyD88/ERK/NFkB pathways and pro-inflammatory cytokines release in periodontal ligament stem cells stimulated by Porphyromonas gingivalis Francesca Diomede,Maria Zingariello,Marcos F.X.B. Cavalcanti,Ilaria Merciaro,Jacopo Pizzicannellaet al. European Journal of Histochemistry, 2017, 61 (2), ⟨10.4081/ejh.2017.2791⟩ Article dans une revue hal-01831940v1
Mechanical stimulations on human bone marrow mesenchymal stem cells enhance cells differentiation in a three-dimensional layered scaffold Jessica Schiavi,Loïc Reppel,Naceur Charif,Natalia de Isla,Didier Mainardet al. Journal of Tissue Engineering and Regenerative Medicine, 2017, 12 (2), pp.360-369. ⟨10.1002/term.2461⟩ Article dans une revue hal-01715211v1
Comparative Study of the Physiotherapeutic and Drug Protocol and Low-Level Laser Irradiation in the Treatment of Pain Associated with Temporomandibular Dysfunction Marcos Fernando Xisto Braga Cavalcanti,Uoston Holder Silva,Ernesto Cesar Pinto Leal-Junior,Rodrigo A.B. Lopes-Martins,Rodrigo Labat Marcoset al. Photomedicine and Laser Surgery, 2016, 34 (12), pp.652-656. ⟨10.1089/pho.2016.4195⟩ Article dans une revue hal-02973719v1
Stem Cells and Regenerative Medicine Jean-François Stoltz,Natalia de Isla,Y. P. Li,,Danièle Bensoussan,L. Zhang,et al. Stem Cells International, 2015, 2015, pp.734731. ⟨10.1155/2015/734731⟩ Article dans une revue hal-01465786v1
Active implant combining human stem cell microtissues and growth factors for bone-regenerative nanomedicine. Jessica Schiavi,Laetitia Keller,David-Nicolas Morand,Natalia De Isla,Olivier Hucket al. Nanomedicine, 2015, 10 (5), pp.753-63. ⟨10.2217/nnm.14.228⟩ Article dans une revue hal-01451383v1
Evaluation of the Proliferative Effects Induced by Low-Level Laser Therapy in Bone Marrow Stem Cell Culture Marcos Fernando Xisto Braga Cavalcanti,Durvanei A. Maria,Natalia De Isla,Ernesto Cesar Pinto Leal-Junior,Jon Joensenet al. Photomedicine and Laser Surgery, 2015, 33 (12), pp.610-616. ⟨10.1089/pho.2014.3864⟩ Article dans une revue hal-01451667v1
Signalling pathways involved in the process of mesenchymal stem cells differentiating into hepatocytes Jun-Song Ye,Xiao-San Su,Jean-François Stoltz,Natalia de Isla,Lei Zhang Cell Proliferation, 2015, 48 (2), pp.157-165. ⟨10.1111/cpr.12165⟩ Article dans une revue hal-01451903v1
Toward an understanding of mechanism of aging-induced oxidative stress in human mesenchymal stem cells Laila Benameur,Naceur Charif,Yueying Li,Jean-François Stoltz,Natalia De Isla Bio-Medical Materials and Engineering, 2015, 25 (1), pp.S41-S46. ⟨10.3233/BME-141247⟩ Article dans une revue hal-01452235v1
Stem cells and applications: A survey Jean-François Stoltz,D. Bensoussan,L. Zhang,V. Decot,Natalia de Islaet al. Bio-Medical Materials and Engineering, 2015, 25 (1), pp.S3-S26. ⟨10.3233/BME-141225⟩ Article dans une revue hal-01452233v1
Application potential of mesenchymal stem cells derived from Wharton's jelly in liver tissue engineering Lei Zhang,Yong-Hen Zhao,Zheng Guan,Jun-Song Ye,Natalia De Islaet al. Bio-Medical Materials and Engineering, 2015, 25 (1), pp.S137-S143. ⟨10.3233/BME-141232⟩ Article dans une revue hal-01452241v1
An approach to preparing decellularized whole liver organ scaffold in rat Jun-Song Ye,Jean-François Stoltz,Natalia De Isla,Yang Liu,Yan-Feng Yinet al. Bio-Medical Materials and Engineering, 2015, 25 (1), pp.S159-S166. ⟨10.3233/BME-141233⟩ Article dans une revue hal-01452240v1
Donor's age dependent proliferation decrease of human bone marrow mesenchymal stem cells is linked to diminished clonogenicity Natalia de Isla,Yueying Li,Naceur Charif,Didier Mainard,Danisle Bensoussanet al. Bio-Medical Materials and Engineering, 2014, 24 (1), pp.S47-S52. ⟨10.3233/BME-140973⟩ Article dans une revue hal-01453218v1
Towards a Tissue-Engineered Ligament: Design and Preliminary Evaluation of a Dedicated Multi-Chamber Tension-Torsion Bioreactor Cédric Laurent,Cédryck Vaquette,Céline Martin,Emmanuel Guedon,Xiude Wuet al. Processes, 2014, 2 (1), pp.167. ⟨10.3390/pr2010167⟩ Article dans une revue hal-01424974v1
Mechanical properties evolution of a PLGA-PLCL composite scaffold for ligament tissue engineering under static and cyclic traction-torsion in vitro culture conditions Cyril Kahn,Kahina Ziani,Ye Min Zang,Jian Liu,Nguyen Tranet al. Journal of Biomaterials Science, Polymer Edition, 2012, 24 (8), pp.899-911. ⟨10.1080/09205063.2012.727265⟩ Article dans une revue hal-00867834v1
Does Making Method of Alginate Hydrogel Influence the Chondrogenic Differentiation of Human Mesenchymal Stem Cells? Jessica Schiavi,Naceur Charif,Natalia De Isla,Danièle Bensoussan,Jean-François Stoltzet al. Engineering, 2012, 04 (10), pp.110-113. ⟨10.4236/eng.2012.410B028⟩ Article dans une revue hal-03782979v1
Human Stem Cells and Articular Cartilage Tissue Engineering J-F. Stoltz,Céline Huselstein,Jessica Schiavi,Y.Y. Li,Danièle Bensoussanet al. Current Pharmaceutical Biotechnology, 2012, 13 (15), pp.2682-2691. ⟨10.2174/138920112804724846⟩ Article dans une revue hal-03782970v1
Research on stem cells as candidates to be differentiated into hepatocytes Lei Zhang,Jun-Song Ye,Veronique Decot,Jean-François Stoltz,Natalia de Isla Bio-Medical Materials and Engineering, 2012, 22 (1-3), pp.105-111. ⟨10.3233/BME-2012-0695⟩ Article dans une revue hal-02973708v1
Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status Leticia Basciano,Christophe Nemos,Bernard Foliguet,Natalia de Isla,Marcelo de Carvalhoet al. BMC Cell Biology, 2011, 12 (1), pp.12. ⟨10.1186/1471-2121-12-12⟩ Article dans une revue hal-02973723v1
Original approach for cartilage tissue engineering with mesenchymal stem cells Jessica Tritz-Schiavi,Naceur Charif,Christel Henrionnet,Natalia de Isla,Danièle Bensoussanet al. Bio-Medical Materials and Engineering, 2010, 20 (3-4), pp.167-174. ⟨10.3233/BME-2010-0628⟩ Article dans une revue hal-03782996v1
Designing a three-dimensional alginate hydrogel by spraying method for cartilage tissue engineering Jessica Tritz,Rachid Rahouadj,Natalia de Isla,Naceur Charif,Astrid Pinzanoet al. Soft Matter, 2010, 6 (20), pp.5165-5174. ⟨10.1039/c000790k⟩ Article dans une revue hal-03697373v1
Collagenous extracellular matrix of cartilage submitted to mechanical forces studied by second harmonic generation microscopy. Elisabeth Werkmeister,Natalia de Isla,Patrick Netter,Jean-François Stoltz,Dominique Dumas Photochemistry and Photobiology, 2010, 86 (2), pp.302-10. ⟨10.1111/j.1751-1097.2009.00648.x⟩ Article dans une revue istex hal-00558986v1
Interest of multimodal imaging in tissue engineering. Elisabeth Werkmeister,Dominique Dumas,Natalia de Isla,Luc Marchal,Jean-François Stoltz Bio-Medical Materials and Engineering, 2008, 18 (4-5), pp.329-33. ⟨10.3233/BME-2008-0548⟩ Article dans une revue hal-00559018v1
Evaluation of human MSCs cell cycle, viability and differentiation in micromass culture. Jing-Wei Yang,Natalia De Isla,Céline Huselstein,Marie-Nathalie Sarda-Kolopp,Na Liet al. Biorheology, 2006, 43 (3,4), pp.489-96 Article dans une revue hal-01981088v1

Communication dans un congrès (16)

The Mechanoadaptation Concept of Cells Jean François Stoltz,Yves Rémond,Daniel George,Jacques Magdalou,Yinping Liet al. 9th International Europe-China Symposium on Stem Cells and Regenerative Medicine, Université de Strasbourg; Association Bioingénierie, Oct 2019, Strasbourg, France. pp.47-59, ⟨10.3233/BHR210010⟩ Communication dans un congrès hal-03245667v1
Relationship between bone marrow mesenchymal stromal cells (MSCs) senescence and clinical evolution of AML and MDS patients after hematopoietic stem cells (HSC) transplantation Meriem El Ouafy,Naceur Charif,Laura Boulangé,Romain Perouf,Allan Bertrandet al. International Cell Senescence Association 2020 Conference (ICSA2020), Dec 2021, Osaka, Japan Communication dans un congrès hal-03626470v1
Impact of in vitro expansion on immunomodulation properties of mesenchymal stromal cells Naceur Charif,Meriem El Ouafy,Dima Ghannoum,Anne-Béatrice Notarantonio,Yinping Liet al. 9th International Symposium Europe China on Stem Cells and Regenerative Medicine, Oct 2019, Strasbourg, France Communication dans un congrès hal-02973617v1
Higher Proliferative Potential of Human Mesenchymal Stromal Cells from Wharton's Jelly Compared to Bone Marrow Is Linked to Decreased Senescence Naceur Charif,Yueying Li,Laurie Targa,Lei Zhang,Yinping Liet al. 2nd International Meeting of the GDRI CNRS 851 CeSMeR “Mesenchymal Stem Cells and Regenerative Medicine”, Oct 2017, Shangrao, China. ⟨10.3233/BHR190019⟩ Communication dans un congrès hal-02973117v1
Senescence of mesenchymal stem cells and its impact on clinical applications Natalia De Isla,Laurie Targa,Naceur Charif,Émilie Roeder,Ghislaine Cauchoiset al. 8th InternationalSymposium China-Europe Stem cells and regenerative medicine, Jun 2018, Wuhan, China Communication dans un congrès hal-02973662v1
Impact of culture conditions on the behavior of mesenchymal stem cells: choosing critical parameters related to cell quality Naceur Charif,Meriem El Ouafy,Laurie Targa,Xing Liu,Audrey Fortunat Zeh Eto'Oet al. 8th InternationalSymposium China-Europe Stem cells and regenerative medicine, Jun 2018, Wuhan, China Communication dans un congrès hal-02973631v1
Mesenchymal stem cells heterogeneity considering surface markers and senescence Laurie Targa,Naceur Charif,Xing Liu,Audrey Fortunat Zeh Eto'O,Mayssa Kacemet al. 8th InternationalSymposium China-Europe Stem cells and regenerative medicine, Jun 2018, Wuhan, China Communication dans un congrès hal-02973642v1
Senescence of mesenchymal stroma cells and clinical applications Dima Ghannoum,Laurie Targa,Naceur Charif,Meriem El Ouafy,Ghislaine Cauchoiset al. 9th International Symposium Europe China on Stem Cells and Regenerative Medicine, Jun 2018, Strasbourg, France Communication dans un congrès hal-03629665v1
Research progress in liver tissue engineering Lei Zhang,Zheng Guan,Jun-Song Ye,Yan-Feng Yin,Jean-François Stoltzet al. 6th China–France International Symposium “Stem Cells and Regenerative Medicine” and the first meeting of the France–China International CNRS Network (GDRI) CeSMeR, Jul 2016, Nancy, France. pp.S113-S119, ⟨10.3233/BME-171632⟩ Communication dans un congrès hal-02973692v1
Rat BMSC infusion was unable to ameliorate inflammatory injuries in tissues of mice with LPS-induced endotoxemia Xiaolin Xie,Hanhan Liu,Jinhua Wu,Yun Chen,Zhui Yuet al. 6th China–France International Symposium “Stem Cells and Regenerative Medicine” and the first meeting of the France–China International CNRS Network (GDRI) CeSMeR, Oct 2016, Nancy, France. pp.S129-S138, ⟨10.3233/BME-171634⟩ Communication dans un congrès hal-02973711v1
New advanced therapy medicinal product for cartilage defect treatment with extemporaneous association of a scaffold and Wharton's jelly mesenchymal stromal cells Loïc Reppel,Céline Huselstein,Natalia de Isla,Nathalie Rouas-Freiss,Philippe Moreauet al. 7th international symposium Europe-China Stem cells and Médecine Regenerative, Oct 2017, Shangrao, China Communication dans un congrès hal-03612827v1
RNM as MCS aging biomarkers : pertinence for regenerative medicine Naceur Charif,Li, Yy,T Kaoma,,Vallar, L,Li, Ypet al. 6th International Symposium Europe-China, Jul 2016, Nancy, France Communication dans un congrès hal-03033120v1
Comprendre l'hétérogénéité des CSM pour des produits de thérapie cellulaire personnalisés Laurie Targa,Yueying Li,Naceur Charif,Mainard Didier,Danièle Bensoussanet al. FR CNRS-UL 3209 Bioingénierie Moléculaire Cellulaire & Thérapeutique "La médecine personnalisée", Dec 2016, Nancy, France Communication dans un congrès hal-02974089v1
Surface markers expressed differently according to MSC source and aging reflects MCS heterogeneity and define MSC subset Laurie Targa,Li, Y,Ye, J,Naceur Charif,Du, Wet al. 6th International Symposium Europe-China, Jul 2016, Nancy, France Communication dans un congrès hal-03033148v1
The importance of mesenchymal stem cell donor’s age for cartilage engineering Yueying Li,Naceur Charif,Didier Mainard,Jean-Francois Stoltz,Natalia De Isla 2014 World Congress on Osteoarthritis, Osteoarthritis Research Society International (OARSI) Apr 2014, Paris, France. pp.S61 Communication dans un congrès hal-01532044v1
Changes in chondrogenesis differentiation potential of bone marrow mesenchymal stem cells according to donor age Yueying Li,Naceur Charif,Didier Mainard,Natalia De Isla,Jean-Francois Stoltz 2013 Osteoarthritis Research Society International (OARSI) World Congress, Apr 2013, Philadelphie, United States. pp.S283 Communication dans un congrès hal-01511185v1

Chapitre d'ouvrage (2)

Response of bone cells to mechanical stimulations: an overview Jean-François Stoltz,Yun Chen,Jacques Magdalou,Daniel George,Céline Huselsteinet al. Stem Cells and Regenerative Medicine, 2019, Biomedical and Health Research, 978-1-61499-925-6. ⟨10.3233/BHR190025⟩ Chapitre d'ouvrage hal-04795586v1
Multimodality of Microscopy Imaging Applied to Cartilage Tissue Engineering. Dominique Dd Dumas,Bibiana Riquelme,Elisabeth Werkmeister,Natalia de Isla,Jean François Stoltz J. Buckwalter, M. Lotz and J.-.Stoltz. Osteoarthritis, Inflammation and Degradation : A Continuum., IOS Press, pp.254-266, 2011, Biomedical and Health Research Chapitre d'ouvrage hal-00559042v1

Poster de conférence (2)

Replicative senescent bone marrow mesenchymal stem cells spotting by surface protein expression Laurie Targa,Naceur Charif,G. Cauchois,Jean-François Stoltz,Jean-Baptiste Vincourtet al. ICSA Conference "The ins and outs of cellular senescence, May 2017, Paris, France Poster de conférence hal-02974106v1
Differences in the expression of cell surface proteins between young and replicative senescent bone marrow mesenchymal stromal / stem cells Laurie Targa,Naceur Charif,Ghislaine Cauchois,Jean-François Stoltz,Jean-Baptiste Vincourtet al. 6th International Symposium Europe-China Mesenchymal Stem Cells and Regenerative Medicine "Molecular, cellular and tissue engineering, and clinical applications”, Jul 2016, Vandoeuvre-Lès-Nancy, France Poster de conférence hal-02974097v1

Thèse (1)

Etude des interactions antigènes-anticorps par des techniques optiques : application aux protéines de surface erythrocytaires Natalia De Isla Autre. Université Henri Poincaré - Nancy 1, 2003. Français. ⟨NNT : 2003NAN11308⟩ Thèse tel-01746925v1