Nathalie LE BRIS

Publications

Article dans une revue (30)

Trehalose-polyamine/DNA nanocomplexes: impact of vector architecture on cell and organ transfection selectivity Fernando Ortega-Caballero,María L Santana-Armas,Conchita Tros de Ilarduya,Christophe Di Giorgio,Raphäel Tripieret al. Journal of materials chemistry‎ B, 2024, 12 (14), pp.3445-3452. ⟨10.1039/d3tb02889e⟩ Article dans une revue hal-04542122v1
Highly inert Cu(II) complexes of C-aryl bifunctional cyclam-picolinates with remarkable Cu-64-labelling and biodistribution Julie Pineau,Luis M P Lima,M Le Roy,Séverine Marionneau-Lambot,Marie Cordieret al. Chemical Communications, 2023, 59 (7), pp.888-891. ⟨10.1039/d2cc06602e⟩ Article dans une revue hal-03969219v1
Preclinical Evaluation of a 64Cu-Based Theranostic Approach in a Murine Model of Multiple Myeloma Cassandra Métivier,Patricia Le Saëc,Joëlle Gaschet,Catherine Chauvet,Séverine Marionneau-Lambotet al. Pharmaceutics, 2023, 15 (7), pp.1817. ⟨10.3390/pharmaceutics15071817⟩ Article dans une revue hal-04161269v1
Palladium(II) coordination with polyazacycloalkanes Nathalie Le Bris,Julie Pineau,Luís M.P. Lima,Raphaël Tripier Coordination Chemistry Reviews, 2022, 455, pp.214343. ⟨10.1016/j.ccr.2021.214343⟩ Article dans une revue hal-03583088v1
Relevance of Palladium to Radiopharmaceutical Development Considering Enhanced Coordination Properties of TE1PA Julie Pineau,Luís M P Lima,Carlos Platas-Iglesias,Jan Rijn Zeevaart,Cathryn H S Driveret al. Chemistry - A European Journal, 2022, 28 (41), pp.e202200942. ⟨10.1002/chem.202200942⟩ Article dans une revue hal-04638161v1
Cyclam-Based Chelators Bearing Phosphonated Pyridine Pendants for 64 Cu-PET Imaging: Synthesis, Physicochemical Studies, Radiolabeling, and Bioimaging Richard C Knighton,Thibault Troadec,Valérie Mazan,Patricia Le Saëc,Séverine Marionneau-Lambotet al. Inorganic Chemistry, 2021, 60 (4), pp.2634-2648. ⟨10.1021/acs.inorgchem.0c03492⟩ Article dans une revue hal-03123032v1
In Vivo Albumin‐Binding of a C ‐Functionalized Cyclam Platform for 64 Cu‐PET/CT Imaging in Breast Cancer Model Thomas Le Bihan,Cathryn Driver,Thomas Ebenhan,Nathalie Le Bris,Jan Rijn Zeevaartet al. ChemMedChem, 2020, ⟨10.1002/cmdc.202000800⟩ Article dans une revue hal-03079054v1
Reactivities of cyclam derivatives with metal–amyloid-β Gunhee Kim,Evan Lelong,Juhye Kang,Jong-Min Suh,Nathalie Le Briset al. Inorganic Chemistry Frontiers, 2020, ⟨10.1039/D0QI00791A⟩ Article dans une revue hal-02961463v1
Synthesis of Orthogonal N -Protected C -Functional Side-Bridged Cyclams to Give Access to Unsymmetrical Constrained BCAs Thomas Le Bihan,Nathalie Le Bris,Hélène Bernard,Carlos Platas-Iglesias,Raphaël Tripier European Journal of Organic Chemistry, 2019, ⟨10.1002/ejoc.201901013⟩ Article dans une revue hal-02270928v1
TE1PA as innovating chelator for 64Cu immuno-TEP imaging: a comparative in vivo study with DOTA/NOTA by conjugation on 9E7.4 mAb in a syngeneic multiple myeloma model Anne-Sophie Navarro,Thomas Le Bihan,Patricia Le Saec,Nathalie Le Bris,Clément Baillyet al. Bioconjugate Chemistry, 2019, ⟨10.1021/acs.bioconjchem.9b00510⟩ Article dans une revue inserm-02266369v1
Synthesis of C-functionalized TE1PA and comparison with its analogues. An example of bioconjugation on 9E7.4 mAb for multiple myeloma 64 Cu-PET imaging Thomas Le Bihan,Anne-Sophie Navarro,Nathalie Le Bris,Patricia Le Saec,Sébastien Gouardet al. Organic & Biomolecular Chemistry, 2018, Epub ahead of print. ⟨10.1039/c8ob00499d⟩ Article dans une revue inserm-01804657v1
Tuning the copper( ii ) coordination properties of cyclam by subtle chemical modifications Nathalie Le Bris,Nathalie Camus,Selbi Nuryyeva,Matthieu Chessé,David Esteban-Gómezet al. Dalton Transactions, 2017, 46 (34), pp.11479 - 11490. ⟨10.1039/C7DT00750G⟩ Article dans une revue hal-01629506v1
Catching anions with coloured assemblies: binding of pH indicators by a giant-size polyammonium macrocycle for anion naked-eye recognition Nathalie Le Bris,Francesco Bartoli,Andrea Bencini,Luca Conti,Claudia Giorgiet al. Organic & Biomolecular Chemistry, 2016, 14 (35), pp.8309 - 8321. ⟨10.1039/c6ob01474g⟩ Article dans une revue hal-01629492v1
A [two-step/one week] synthesis of C-functionalized homocyclens and cyclams. Application to the preparation of conjugable BCAs without chelating properties alteration Nathalie Camus,Zakaria Halime,Nathalie Le Bris,Hélène Bernard,Maryline Beyleret al. RSC Advances, 2015, 5 (104), pp.85898 - 85910. ⟨10.1039/c5ra17133d⟩ Article dans une revue hal-01517785v1
Full Control of the Regiospecific N -Functionalization of C -Functionalized Cyclam Bisaminal Derivatives and Application to the Synthesis of their TETA, TE2A, and CB-TE2A Analogues Nathalie Le Bris,Nathalie Camus,Zakaria Halime,Hélène Bernard,Carlos Platas-Iglesiaset al. Journal of Organic Chemistry, 2014, 79 (5), pp.1885 - 1899. ⟨10.1021/jo4028566⟩ Article dans une revue hal-01629496v1
A new bis-tetraamine ligand with a chromophoric 4-(9-anthracenyl)-2,6-dimethylpyridinyl linker for glyphosate and ATP sensing Jacky Pouessel,Nathalie Le Bris,Sabah Abada,Mourad Elhabiri,Loïc J. Charbonnièreet al. Dalton Transactions, 2013, 42 (14), ⟨10.1039/c3dt32325k⟩ Article dans une revue hal-01629499v1
Glyphosate and ATP binding by mononuclear Zn(ii) complexes with non-symmetric ditopic polyamine ligands Jacky Pouessel,Nathalie Le Bris,Andrea Bencini,Claudia Giorgi,Barbara Valtancoliet al. Dalton Transactions, 2012, 41 (35), ⟨10.1039/C2DT31110K⟩ Article dans une revue hal-01556793v1
1,2,4-Triazine method of bipyridine ligand synthesis for the preparation of new luminescent Eu(III) complexes Nathalie Le Bris,Anton Prokhorov,Valery N. Kozhevnikov,Dmitry S. Kopchuk,Hélène Bernardet al. Tetrahedron, 2011, 67 (3), pp.597 - 607. ⟨10.1016/j.tet.2010.11.058⟩ Article dans une revue istex hal-01629509v1
Selective Binding of Glyphosate by a Ditopic Cyclic-Open-Chain Polyazaligand in Aqueous Solution Nathalie Le Bris,Jacky Pouessel,Andrea Bencini,Claudia Giorgi,Henri Handelet al. European Journal of Organic Chemistry, 2011, 2011 (34), pp.6965 - 6973. ⟨10.1002/ejoc.201100972⟩ Article dans une revue istex hal-01629511v1
Exploring New Molecular Architectures for Anion Recognition: Synthesis and ATP Binding Properties of New Cyclam-Based Ditopic Polyammonium Receptors. Nathalie Le Bris,Jacky Pouessel,Carla Bazzicalupi,Andrea Bencini,Hélène Bernardet al. Chemistry - An Asian Journal, 2011, 6 (6), pp.1582 - 1594. ⟨10.1002/asia.201100046⟩ Article dans une revue istex hal-01629512v1
Selective mono-N-alkylation of triethylenetetraamine. A new versatile route to polylinear aza-ligands Nathalie Le Bris,Anne-Sophie Delépine,Raphaël Tripier,Hélène Bernard,Henri Handel Tetrahedron Letters, 2009, 50 (21), pp.2521 - 2524. ⟨10.1016/j.tetlet.2009.03.088⟩ Article dans une revue istex hal-01580187v1
ATP and triphosphate anions complexation by bis-linear tetraamines: Strong interactions at neutral pH Nathalie Le Bris,Anne-Sophie Delépine,Raphaël Tripier,Hélène Bernard,Aurelien Honraedtet al. Inorganica Chimica Acta Reviews, 2009, 362 (10), pp.3829 - 3834. ⟨10.1016/j.ica.2009.05.003⟩ Article dans une revue istex hal-01629518v1
Synthesis of a New Linear-Cyclic Ditopic Polyazaligand with a Xylenyl Linker Nathalie Le Bris,Hélène Bernard,Zein El Abidine Chamas,Henri Handel Synthetic Communications, 2009, 39 (11), pp.1992 - 2000. ⟨10.1080/00397910802630203⟩ Article dans une revue hal-01629515v1
Selective mono-N-alkylation of triethylenetetraamine. A new versatile route to polylinear aza-ligands Nathalie Le Bris,Anne-Sophie Delépine,Raphaël Tripier,Hélène Bernard,Henri Handel Tetrahedron Letters, 2009, 50 (21), pp.2521 - 2524. ⟨10.1016/j.tetlet.2009.03.088⟩ Article dans une revue istex hal-01629513v1
Synthesis of a New Ditopic Ligand Possessing Linear and Cyclic Tetraaza Subunits Nathalie Le Bris,Anton Prokhorov,Hélène Bernard,Nicolas Marquet,Henri Handel Synthetic Communications, 2008, 38 (10), pp.1589 - 1600. ⟨10.1080/00397910801929481⟩ Article dans une revue hal-01629521v1
A potentiometric and NMR investigation of triphosphate recognition by linear and bismacrocyclic octaamines possessing a 1,4-xylenyl linker Nathalie Le Bris,Hélène Bernard,Raphaël Tripier,Henri Handel Inorganica Chimica Acta Reviews, 2007, 360 (9), pp.3026 - 3032. ⟨10.1016/j.ica.2007.02.041⟩ Article dans une revue istex hal-01629525v1
Cyclohexanedione Bisaminals as Intermediates for Cyclen, Homocyclen, and Cyclam Synthesis Nathalie Le Bris,Anton Prokhorov,Hélène Bernard,Géraldine Claudon,Henri Handel Synthetic Communications, 2006, 36 (21), pp.3271 - 3282. ⟨10.1080/00397910600910633⟩ Article dans une revue hal-01629526v1
PowerfulN-Monoalkylation of Linear Tetraamines via Bisaminal Intermediates Géraldine Claudon,Nathalie Le Bris,Hélène Bernard,Henri Handel European Journal of Organic Chemistry, 2004, 2004 (24), pp.5027 - 5030. ⟨10.1002/ejoc.200400459⟩ Article dans une revue istex hal-01629489v1
Rhodium Complexes of Bidentate and Potentially Hemilabile Phosphorus Ligands for Hydroformylation of Styrene at Low Temperature Pascale Laurent,Nathalie Le Bris,Herve Des Abbayes ChemInform, 2004, 35 (45), ⟨10.1002/chin.200445272⟩ Article dans une revue istex hal-04547457v1
Phosphonolipids as non-viral vectors for gene therapy V. Floch,G. Le Bolc'H,C. Gable-Guillaume,Nathalie Le Bris,J.-J. Yaouancet al. European Journal of Medicinal Chemistry, 1998, 33, pp.923--934. ⟨10.1016/S0223-5234(99)80017-8⟩ Article dans une revue istex hal-01770726v1

Communication dans un congrès (9)

Optimisation d’un Agent Chélatant Avancé pour la Production de Radiopharmaceutiques en Médecine Nucléaire Personnalisée Julie Pineau,Nathalie Le Bris,Raphaël Tripier Journée IBSAM, Mar 2024, Brest, France Communication dans un congrès hal-04547231v1
A competitive chelating agent for the development of radiopharmaceuticals in personalized nuclear medicine Julie Pineau,Nathalie Le Bris,Raphaël Tripier GECOM-CONCOORD 2024, May 2024, Ax-les-Thermes, France Communication dans un congrès hal-04547260v1
New CuAAC-based method to reach bifunctional cyclam derivatives application in cancer imaging and therapy Cédric Ollier,Nathalie Le Bris,Raphaël Tripier SCF Western section, Jun 2024, Logonna-Daoulas, France Communication dans un congrès hal-04547240v1
Vers de nouveaux radiopharmaceutiques au cuivre pour l’imagerie TEP et la thérapie des cancers Cédric Ollier,Nathalie Le Bris,Raphaël Tripier Journée IBSAM, Nov 2023, Brest, France Communication dans un congrès hal-04547221v1
Functionalization of TE1PA derivatives via CuAAC for cancer imaging and therapy Cédric Ollier,Nathalie Le Bris,Raphaël Tripier SECO, May 2023, Arëches-Beaufort, France Communication dans un congrès hal-04547205v1
Cyclam as Relevant Platform to Design 99mTc, 64Cu, or 109Pd Radiopharmaceuticals in Nuclear Medicine Maher Hojorat,Nathalie Le Bris,Raphaël Tripier ISMEC, Jun 2023, Urbino, Italy Communication dans un congrès hal-04547213v1
In vivo albumin-binding of a cyclam-based platform for imaging and therapy of cancers Julie Pineau,Nathalie Le Bris,Raphaël Tripier GECOM Mini, Jul 2021, Webinaire, France Communication dans un congrès hal-04547156v1
Développement de radiopharmaceutiques à base de cyclam pour l'imagerie TEP au cuivre-64 et la thérapie des cancers Nathalie Le Bris,Julie Pineau,Raphaël Tripier Journée de l'Ecole Doctorale 3M, May 2021, Webinaire, France Communication dans un congrès hal-04547151v1
Novel 64Cu/109Pd theranostic pair for a TE1PA-based trifunctional chelating agent Julie Pineau,Nathalie Le Bris,Raphaël Tripier SCF western section, Sep 2021, Rennes, France Communication dans un congrès hal-04547167v1

Poster de conférence (3)

64Cu/*Pd-GluCAB: an in vivo albumin-binding theranostic radiopharmaceutical for dual active and passive targeting of breast cancer Nathalie Le Bris,Raphaël Tripier International Symposium on Trends in Radiopharmaceuticals, Apr 2023, Vienna, Austria Poster de conférence hal-04547303v1
Neutral Copper(II) TE1PA-based chelate for 64Cu-PET imaging: when an additional carboxyl group makes the difference Julie Pineau,Nathalie Le Bris,Raphaël Tripier New Modalities in Cancer Imaging and Therapy. Cancéropôle Grand-Ouest, Oct 2022, Erquy, France Poster de conférence hal-04547281v1
Relevance of palladium to radiopharmaceutical development considering enhanced. Julie Pineau,Nathalie Le Bris,Raphaël Tripier New Modalities in Cancer Imaging and Therapy. Cancéropôle Grand Ouest, Oct 2022, Erquy, France Poster de conférence hal-04547294v1

Brevet (1)

PICOLINATE CYCLAM PALLADIUM CHELATES AND USES THEREOF Raphaël Tripier,Nathalie Le Bris,Julie Pineau France, Patent n° : EP 4 273 142 A1. 2022 Brevet hal-04545875v1