Nathalie Sans Directrice de Recherche Inserm

Présentation

Cursus Académique

1996 - Doctorat de l'Université Montpellier II, Montpellier.

2014 Habilitation à diriger des recherches, Université de Bordeaux Segalen

Carrière

1997-2002 : Post-Doc National Institutes of Health, USA

2003-2005: Senior Research Fellow, NIH, MD, USA

2007 : Chargée de recherche Inserm

2014 : Directrice de recherche Inserm

Fonctions

2015-2021 Directrice Adjointe de l’UMR U1215 INSERM-UM et Responsable équipe &quot;planar Polarity and Plasticity&quot;

2016-2019 Directrice Adjointe du département SVS de l'Univ. de Bordeaux

2019-2021 Directrice du département Bordeaux Neurocampus de l'Univ. de Bordeaux

2022-2026 Vice -présidente en charge de la recherche, Univ. de Bordeaux

Publications

Article dans une revue (22)

The correct connectivity of the DG-CA3 circuits involved in declarative memory processes depends on Vangl2-dependent planar cell polarity signaling Noémie Depret,Marie Gleizes,Maïté Marie Moreau,Sonia Poirault-Chassac,Anne Quiedevilleet al. Progress in Neurobiology, 2025, pp.102728. ⟨10.1016/j.pneurobio.2025.102728⟩ Article dans une revue hal-04960513v1
MuSK cysteine-rich domain antibodies are pathogenic in a mouse model of autoimmune myasthenia gravis Marius Halliez,Steve Cottin,Axel You,Céline Buon,Antony Grondinet al. The Journal of clinical investigation, 2025, 135, ⟨10.1172/jci173308⟩ Article dans une revue hal-05344474v1
The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling Ana Dorrego-Rivas,Jerome Ezan,Maïté Moreau,Sonia Poirault-Chassac,Nathalie Aubaillyet al. Science Advances , 2022, 8 (36), ⟨10.1126/sciadv.abo6333⟩ Article dans une revue hal-03856056v1
Scribble Controls Social Motivation Behavior through the Regulation of the ERK/Mnk1 Pathway Maite M. Moreau,Susanna Pietropaolo,Jerome Ezan,Benjamin J. A. Robert,Sylvain Mirauxet al. Cells, 2022, 11 (10), pp.1601. ⟨10.3390/cells11101601⟩ Article dans une revue hal-03709848v1
Neuron-Specific Deletion of in Mice Leads to Neuroanatomical and Locomotor Deficits. Jerome Ezan,Maite Moreau,Tamrat M Mamo,Miki Shimbo,Maureen Decrooet al. Frontiers in Genetics, 2022, 13, pp.872700. ⟨10.3389/fgene.2022.872700⟩ Article dans une revue hal-03709715v1
The cell polarity protein Vangl2 in the muscle shapes the neuromuscular synapse by binding to and regulating the tyrosine kinase MuSK Myriam Boëx,Steve Cottin,Marius Halliez,Stéphanie Bauché,Céline Buonet al. Science Signaling, 2022, 15 (734), pp.eabg4982. ⟨10.1126/scisignal.abg4982⟩ Article dans une revue inserm-03768653v1
Early loss of Scribble affects cortical development, interhemispheric connectivity and psychomotor activity Jerome Ezan,Maite M. Moreau,Tamrat M. Mamo,Miki Shimbo,Maureen Decrooet al. Scientific Reports, 2021, 11, pp.9106. ⟨10.1038/s41598-021-88147-1⟩ Article dans une revue hal-03424316v1
Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth Steve Dos-Santos Carvalho,Maite Moreau,Yeri Esther Hien,Mikael Garcia,Nathalie Aubaillyet al. eLife, 2020, 9, ⟨10.7554/eLife.51822⟩ Article dans une revue hal-02996265v1
Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion Benjamin J.A. Robert,Maïté M Moreau,Steve dos Santos Carvalho,Gael Barthet,Claudia Raccaet al. Cell Reports, 2020, 31 (10), pp.107743. ⟨10.1016/j.celrep.2020.107743⟩ Article dans une revue hal-03402580v1
Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion Benjamin J.A. Robert,Maïté Moreau,Steve dos Santos Carvalho,Gael Barthet,Claudia Raccaet al. Cell Reports, 2020, 31 (10), pp.107743. ⟨10.1016/j.celrep.2020.107743⟩ Article dans une revue hal-03367473v1
Alpha technology: A powerful tool to detect mouse brain intracellular signaling events Marion Zanese,Giovanni Tomaselli,Valérie Roullot-Lacarrière,Maïté Moreau,Luigi Bellocchioet al. Journal of Neuroscience Methods, 2020, 332, pp.108543. ⟨10.1016/j.jneumeth.2019.108543⟩ Article dans une revue hal-02990027v1
Age‐related impairment of declarative memory: linking memorization of temporal associations to GluN2B redistribution in dorsal CA1 Alice Shaam Al Abed,Azza Sellami,Mylene Potier,Eva‐gunnel Ducourneau,Pauline Gerbeaud‐lassauet al. Aging Cell, 2020, 19 (10), pp.e13243. ⟨10.1111/acel.13243⟩ Article dans une revue hal-02960264v1
Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways Julien Messéant,Jérôme Ezan,Perrine Delers,Konstantin Glebov,Carmen Marchiolet al. Development (Cambridge, England), 2017, 144 (9), pp.1712 - 1724. ⟨10.1242/dev.146167⟩ Article dans une revue hal-01542853v1
Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome Stephanie A. Mauriac,Yeri E. Hien,Jonathan E. Bird,Steve dos Santos Carvalho,Ronan Peyroutouet al. Nature Communications, 2017, 8, pp.14907. ⟨10.1038/ncomms14907⟩ Article dans une revue hal-03724003v1
Activity-Dependent Neuroplasticity Induced by an Enriched Environment Reverses Cognitive Deficits in Scribble Deficient Mouse Muna L Hilal,Maité M Moreau,Claudia Racca,Vera L Pinheiro,Nicolas H Piguelet al. Cerebral Cortex, 2017, 27 (12), pp.5635-5651. ⟨10.1093/cercor/bhw333⟩ Article dans une revue hal-01789668v1
Nutritional omega-3 deficiency alters glucocorticoid receptor-signaling pathway and neuronal morphology in regionally distinct brain structures associated with emotional deficits Thomas Larrieu,Muna L. Hilal,Veronique de Smedt-Peyrusse,Nathalie Sans,Sophie Layé Neural plasticity, 2016, pp.1-9. ⟨10.1155/2016/8574830⟩ Article dans une revue hal-02631971v1
Scribble1/AP2 complex coordinates NMDA receptor endocytic recycling Nicolas H. Piguel,Sabine Fievre,Jean-Michel Blanc,Mario Carta,Maïté M. Moreauet al. Cell Reports, 2014, 9 (2), pp.712-727. ⟨10.1016/j.celrep.2014.09.017⟩ Article dans une revue hal-01944934v1
Dendritic channelopathies contribute to neocortical and sensory hyperexcitability in Fmr1 −/y mice Yu Zhang,Audrey Bonnan,Guillaume Bony,Isabelle Ferezou,Susanna Pietropaoloet al. Nature Neuroscience, 2014, 17 (12), pp.1701-1709. ⟨10.1038/nn.3864⟩ Article dans une revue hal-02064702v1
Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton. Jerome Ezan,Léa Lasvaux,Aysegul Gezer,Ana Novakovic,Helen May-Simeraet al. Nature Cell Biology, 2013, 15 (9), pp.1107-15. ⟨10.1038/ncb2819⟩ Article dans une revue hal-00862161v1
Gipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear Arnaud P. Giese,Jerome Ezan,Lingyan Wang,Lea Lasvaux,Frederique Lemboet al. Development (Cambridge, England), 2012, 139 (20), pp.3775-3785. ⟨10.1242/dev.074229⟩ Article dans une revue hal-03710271v1
SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism Nathalie Sans,Christelle M Durand,Julie Perroy,Francois Loll,David Perraiset al. Molecular Psychiatry, 2011, ⟨10.1038/mp.2011.57⟩ Article dans une revue hal-00644264v1
The Planar Polarity Protein Scribble1 Is Essential for Neuronal Plasticity and Brain Function Maïté M Moreau,Nicolas Piguel,Thomas Papouin,Muriel Koehl,Christelle M Durandet al. Journal of Neuroscience, 2010, 30 (29), pp.9738-9752. ⟨10.1523/JNEUROSCI.6007-09.2010⟩ Article dans une revue hal-02326134v1

Poster de conférence (1)

Core PCP protein Vangl2 is essential to the structural and functional development of the hippocampal mossy fiber bouton/thorny excrescences (MfB/TE) synapse. Marie Gleizes,Noémie Depret,Gael Barthet,Christophe Mulle,Claudia Raccaet al. NeuroFrance, May 2023, Lyon (Centre des Congrès), France Poster de conférence hal-04932317v1

Pré-publication, Document de travail (1)

Scribble controls social behaviors through the regulation of the ERK/Mnk1 pathway Maïté M Moreau,Susanna Pietropaolo,Jérôme Ezan,Benjamin J A Robert,Sylvain Mirauxet al. 2020 Pré-publication, Document de travail hal-03029888v1