Nicolas Blondeau Directeur de Recherche CNRS

Identifiants chercheurs

IdHAL :

nicolas-blondeau

ORCID :

0000-0001-5954-4094

IdRef :

074474936

ResearcherID :

M-5002-2016

Publications

Article dans une revue (69)

How to Pick a Neuroprotective Drug in Stroke Without Losing Your Mind? Joseph S Tauskela,Nicolas Blondeau Life, 2025, 15 (6), pp.883. ⟨10.3390/life15060883⟩ Article dans une revue hal-05131058v1
Deciphering the brain glucose metabolism: A gateway to innovative stroke therapies Didier F Pisani,Nicolas Blondeau Journal of Cerebral Blood Flow and Metabolism, In press, ⟨10.1177/0271678x251346277⟩ Article dans une revue hal-05130005v1
Targeting seryl-tRNA synthetase to unlock ischemic resilience in stroke – Insights from a proof-of-concept study Miled Bourourou,Nicolas Melis,Marc Cougnon,Gilbert Laffet,Christophe Durantonet al. Journal of Cerebral Blood Flow and Metabolism, 2025, ⟨10.1177/0271678x251347810⟩ Article dans une revue hal-05129982v1
Enhancing Solubility and Bioefficacy of Stilbenes by Liposomal Encapsulation─The Case of Macasiamenene F Veronika Brezani,Nicolas Blondeau,Jan Kotouček,Eva Klásková,Karel Šmejkalet al. ACS Omega, 2024, ⟨10.1021/acsomega.3c07380⟩ Article dans une revue hal-04477610v1
Decoding the science behind antioxidant -antiinflammatory nutraceuticals in stroke Sophie Béraud-Dufour,Ilona Legroux,Thierry Coppola,Patricia Lebrun,Nicolas Blondeau Conditioning Medicine, 2024, 7 Article dans une revue hal-05360773v1
Unlocking Therapeutic Synergy: Tailoring Drugs for Comorbidities such as Depression and Diabetes through Identical Molecular Targets in Different Cell Types Thierry Coppola,Guillaume Daziano,Ilona Legroux,Sophie Béraud-Dufour,Nicolas Blondeauet al. Cells, 2023, 12 (23), pp.2768. ⟨10.3390/cells12232768⟩ Article dans une revue hal-04322771v1
Linotrins: Omega-3 oxylipins featuring an E,Z,E conjugated triene motif are present in the plant kingdom and alleviate inflammation in LPS-challenged microglial cells Laurence Balas,Sujit Kumar Dey,Sophie Béraud-Dufour,Dean Edward Riechers,Olivia Augusta Landauet al. European Journal of Medicinal Chemistry, 2022, 231, pp.114157. ⟨10.1016/j.ejmech.2022.114157⟩ Article dans une revue hal-03560829v1
Dietary fat exacerbates postprandial hypothalamic inflammation involving glial fibrillary acidic protein-positive cells and microglia in male mice Céline Cansell,Katharina Stobbe,Clara Sanchez,Ophélia Le Thuc,Coralie-Anne Mosseret al. Glia, 2021, 69 (1), pp.42-60. ⟨10.1002/glia.23882⟩ Article dans une revue hal-02899910v1
Inhibition of eIF5A hypusination reprogrammes metabolism and glucose handling in mouse kidney Marc Cougnon,Romain Carcy,Nicolas Melis,Isabelle Rubera,Christophe Durantonet al. Cell Death and Disease, 2021, 12 (4), ⟨10.1038/s41419-021-03577-z⟩ Article dans une revue hal-03176556v1
Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathway Guillaume Daziano,Nicolas Blondeau,Sophie Béraud-Dufour,Amar Abderrahmani,Carole Rovèreet al. Pharmacological Research, 2021, 167, pp.105539. ⟨10.1016/j.phrs.2021.105539⟩ Article dans une revue hal-03176756v1
Combattre l’accident vasculaire cérébral en inhibant une enzyme liée à la voie de synthèse des polyamines Nicolas Blondeau Médecine/Sciences, 2021, 37 (6-7), pp.575-577. ⟨10.1051/medsci/2021068⟩ Article dans une revue hal-03273129v1
Therapeutic potential of prenylated stilbenoid macasiamenene F through its anti-inflammatory and cytoprotective effects on LPS-challenged monocytes and microglia Veronika Leláková,Sophie Béraud-Dufour,Jan Hošek,Karel Šmejkal,Vilailak Prachyawarakornet al. Journal of Ethnopharmacology, 2020, pp.113147. ⟨10.1016/j.jep.2020.113147⟩ Article dans une revue hal-02912692v1
Inhibition of eIF5A hypusination pathway as a new pharmacological target for stroke therapy Miled Bourourou,Elsa Gouix,Nicolas Melis,Jonas Friard,Catherine Heurteauxet al. Journal of Cerebral Blood Flow and Metabolism, 2020, pp.0271678X2092888. ⟨10.1177/0271678X20928882⟩ Article dans une revue hal-02899981v1
A new pharmacological preconditioning-based target: from drosophila to kidney transplantation Michel Tauc,Nicolas Melis,Miled Bourourou,Sébastien Giraud,Thierry Hauetet al. Conditioning Medicine, 2019 Article dans une revue hal-02265197v1
An acute coronary syndrome in Antarctica Mathieu Carron,Fanny Hamard,Jacques Levraut,Nicolas Blondeau International maritime health, 2019, 70 (3), pp.167-170. ⟨10.5603/IMH.2019.0026⟩ Article dans une revue hal-02336412v1
Bridging the Gap Between Diabetes and Stroke in Search of High Clinical Relevance Therapeutic Targets Thierry Coppola,Sophie Béraud-Dufour,Patricia Lebrun,Nicolas Blondeau NeuroMolecular Medicine, 2019, ⟨10.1007/s12017-019-08563-5⟩ Article dans une revue hal-02322686v1
Sortilin in Glucose Homeostasis: From Accessory Protein to Key Player? Nicolas Blondeau,Sophie Béraud-Dufour,Patricia Lebrun,Céline Hivelin,Thierry Coppola Frontiers in Pharmacology, 2019, 9, ⟨10.3389/fphar.2018.01561⟩ Article dans une revue hal-02265199v1
Requirement for preclinical prioritization of neuroprotective strategies in stroke: Incorporation of preconditioning Tauskela Joseph S.,Blondeau Nicolas Conditioning Medicine, 2018 Article dans une revue hal-02057375v1
Ionic Homeostasis Maintenance in ALS: Focus on New Therapeutic Targets Rossana Sirabella,Valeria Valsecchi,Serenella Anzilotti,Ornella Cuomo,Antonio Vinciguerraet al. Frontiers in Neuroscience, 2018, 12, ⟨10.3389/fnins.2018.00510⟩ Article dans une revue hal-02265200v1
Cruise ship pathologies in remote regions Mathieu Carron,Nicolas Emeyriat,Jacques Levraut,Nicolas Blondeau International maritime health, 2018, 69 (2), pp.75-83. ⟨10.5603/IMH.2018.0012⟩ Article dans une revue hal-02265201v1
Tackling issues in the path toward clinical translation in brain conditioning: Potential offered by nutraceuticals Joseph S Tauskela,Miled Bourourou,Nicolas Blondeau Brain Circulation, 2017, ⟨10.4103/bc.bc_8_17⟩ Article dans une revue hal-02265208v1
Targeting eIF5A Hypusination Prevents Anoxic Cell Death through Mitochondrial Silencing and Improves Kidney Transplant Outcome Nicolas Melis,Isabelle Rubera,Marc Cougnon,Sébastien Giraud,Baharia Mograbiet al. Journal of the American Society of Nephrology, 2017, 28 (3), pp.811-822. ⟨10.1681/ASN.2016010012⟩ Article dans une revue hal-02465982v1
Hypothalamic Inflammation and Energy Balance Disruptions: Spotlight on Chemokines Ophélia Le Thuc,Katharina Stobbe,Céline Cansell,Jean-Louis Nahon,Nicolas Blondeauet al. Frontiers in Endocrinology, 2017, 8, ⟨10.3389/fendo.2017.00197⟩ Article dans une revue hal-02265209v1
Alpha-linolenic acid given as enteral or parenteral nutritional intervention against sensorimotor and cognitive deficits in a mouse model of ischemic stroke Miled Bourourou,Catherine Heurteaux,Nicolas Blondeau Neuropharmacology, 2016, 108, pp.60-72. ⟨10.1016/j.neuropharm.2016.04.040⟩ Article dans une revue hal-02266080v1
Central CCL2 signaling onto MCH neurons mediates metabolic and behavioral adaptation to inflammation Ophélia Le Thuc,Céline Cansell,Miled Bourourou,Raphaël Gp Denis,Katharina Stobbeet al. EMBO Reports, 2016, 17 (12), pp.1738-1752. ⟨10.15252/embr.201541499⟩ Article dans une revue hal-02266078v1
A Potent Protective Role of Lysophospholipids Against Global Cerebral Ischemia and Glutamate Excitotoxicity in Neuronal Cultures Nicolas Blondeau,Inger Lauritzen,Catherine Widmann,Michel Lazdunski,Catherine Heurteaux Journal of Cerebral Blood Flow and Metabolism, 2016, 22 (7), pp.821-834. ⟨10.1097/00004647-200207000-00007⟩ Article dans une revue hal-02266278v1
The nutraceutical potential of omega-3 alpha-linolenic acid in reducing the consequences of stroke Nicolas Blondeau Biochimie, 2016, 120, pp.49-55. ⟨10.1016/j.biochi.2015.06.005⟩ Article dans une revue hal-02266089v1
Failure and rescue of preconditioning-induced neuroprotection in severe stroke-like insults Joseph Tauskela,Amy Aylsworth,Melissa Hewitt,Eric Brunette,Nicolas Blondeau Neuropharmacology, 2016, 105, pp.533-542. ⟨10.1016/j.neuropharm.2016.02.007⟩ Article dans une revue hal-02265212v1
The complex contribution of chemokines to neuroinflammation: switching from beneficial to detrimental effects Ophélia Le Thuc,Nicolas Blondeau,Jean-Louis Nahon,Carole Rovère Annals of the New York Academy of Sciences, 2015, 1351 (1), pp.127-140. ⟨10.1111/nyas.12855⟩ Article dans une revue istex hal-02266096v1
Alpha-Linolenic Acid: An Omega-3 Fatty Acid with Neuroprotective Properties—Ready for Use in the Stroke Clinic? Nicolas Blondeau,Robert Lipsky,Miled Bourourou,Mark Duncan,Philip Gorelicket al. BioMed Research International , 2015, 2015, pp.1-8. ⟨10.1155/2015/519830⟩ Article dans une revue hal-02266097v1
Oxygen glucose deprivation-induced astrocyte dysfunction provokes neuronal death through oxidative stress E. Gouix,A. Buisson,A. Nieoullon,L. Kerkerian-Legoff,Js Tauskelaet al. Pharmacological Research, 2014, 87, pp.8-17. ⟨10.1016/j.phrs.2014.06.002⟩ Article dans une revue istex hal-01112536v1
Alpha-linolenic acid: A promising nutraceutical for the prevention of stroke Carine Nguemeni,Elsa Gouix,Miled Bourourou,Catherine Heurteaux,Nicolas Blondeau PharmaNutrition, 2013, 1 (1), pp.1-8 Article dans une revue hal-02057392v1
Alpha-linolenic acid: A promising nutraceutical for the prevention of stroke Carine Nguemeni,Elsa Gouix,Miled Bourourou,Catherine Heurteaux,Nicolas Blondeau PharmaNutrition, 2013, 1 (1), pp.1-8. ⟨10.1016/j.phanu.2012.12.002⟩ Article dans une revue hal-02266098v1
Alpha-linolenic omega-3 fatty acid for stroke protection: from brain preconditioning paradigm to nutrition Nicolas Blondeau Oléagineux, Corps Gras, Lipides, 2011, ⟨10.1684/ocl.2011.0389⟩ Article dans une revue hal-02266100v1
Peroxisome proliferator-activated receptor gamma induces apoptosis and inhibits autophagy of human monocyte-derived macrophages via induction of cathepsin L: potential role in atherosclerosis. Dler Faieeq Darweesh Mahmood,Imene Jguirim-Souissi,El-Hadri Khadija,Nicolas Blondeau,Vimala Diderotet al. Journal of Biological Chemistry, 2011, 286 (33), pp.28858-66. ⟨10.1074/jbc.M111.273292⟩ Article dans une revue hal-00726335v1
Association of phenylbutazone usage with horses bought for slaughter: a public health risk. Nicholas Dodman,Nicolas Blondeau,Ann M Marini Food and Chemical Toxicology, 2010, 48 (5), pp.1270-4. ⟨10.1016/j.fct.2010.02.021⟩ Article dans une revue istex hal-00496982v1
Dietary supplementation of alpha-linolenic acid in an enriched rapeseed oil diet protects from stroke. C. Nguemeni,B. Delplanque,C. Rovère,N. Simon-Rousseau,C. Gandinet al. Pharmacological Research, 2010, 61 (3), pp.226-33. ⟨10.1016/j.phrs.2009.12.007⟩ Article dans une revue istex hal-00497117v1
The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases. Grégory Conductier,Nicolas Blondeau,Alice Guyon,Jean-Louis Nahon,Carole Rovère Journal of Neuroimmunology, 2010, 224 (1-2), pp.93-100. ⟨10.1016/j.jneuroim.2010.05.010⟩ Article dans une revue istex hal-00858500v1
Subchronic Alpha-Linolenic Acid Treatment Enhances Brain Plasticity and Exerts an Antidepressant Effect: A Versatile Potential Therapy for Stroke. Nicolas Blondeau,C. Nguemeni,David N Debruyne,Marie Piens,Xuan Wuet al. Neuropsychopharmacology, 2009, epub ahead of print. ⟨10.1038/npp.2009.84⟩ Article dans une revue hal-00418411v1
Concomitant transitory up-regulation of X-linked inhibitor of apoptosis protein (XIAP) and the heterogeneous nuclear ribonucleoprotein C1-C2 in surviving cells during neuronal apoptosis. A. Spahn,N. Blondeau,C. Heurteaux,F. Dehghani,A. Rami Neurochemical Research, 2008, 33 (9), pp.1859-68. ⟨10.1007/s11064-008-9658-0⟩ Article dans une revue istex hal-00312699v1
Brain adaptation to stressful stimuli: a new perspective on potential therapeutic approaches based on BDNF and NMDA receptors. Ann M Marini,Margherita Popolo,Hongna Pan,Nicolas Blondeau,Robert H Lipsky CNS Neurol Disord Drug Targets, 2008, 7 (4), pp.382-90 Article dans une revue hal-00435991v1
Polyunsaturated fatty acids are cerebral vasodilators via the TREK-1 potassium channel. Nicolas Blondeau,Olivier Pétrault,Stella Manta,Valérie Giordanengo,Pierre Gounonet al. Circulation Research, 2007, 101 (2), pp.176-84. ⟨10.1161/CIRCRESAHA.107.154443⟩ Article dans une revue hal-00171737v1
Preconditioning and neurotrophins: a model for brain adaptation to seizures, ischemia and other stressful stimuli A. Marini,X. Jiang,X. Wu,H. Pan,Z. Guoet al. Amino Acids, 2007, 32 (3), pp.299-304. ⟨10.1007/s00726-006-0414-y⟩ Article dans une revue istex hal-02266112v1
Distribution of sphingosine kinase activity and mRNA in rodent brain Nicolas Blondeau,Yushuan Lai,Sarah Tyndall,Margherita Popolo,Kamil Topalkaraet al. Journal of Neurochemistry, 2007, 103 (2), pp.509-517. ⟨10.1111/j.1471-4159.2007.04755.x⟩ Article dans une revue hal-02266122v1
Altered acetylcholine, bradykinin and cutaneous pressure-induced vasodilation in mice lacking the TREK1 potassium channel: the endothelial link. Ambroise Garry,Bérengère Fromy,Nicolas Blondeau,Daniel Henrion,Frédéric Brauet al. EMBO Reports, 2007, 8 (4), pp.354-9. ⟨10.1038/sj.embor.7400916⟩ Article dans une revue hal-00171740v1
Preconditioning and neurotrophins: a model for brain adaptation to seizures, ischemia and other stressful stimuli. A. M. Marini,X. Jiang,X. Wu,H. Pan,Z. Guoet al. Amino Acids, 2007, 32 (3), pp.299-304. ⟨10.1007/s00726-006-0414-y⟩ Article dans une revue istex hal-00312712v1
A tarantula peptide against pain via ASIC1a channels and opioid mechanisms. Michel Mazzuca,Catherine Heurteaux,Abdelkrim Alloui,Sylvie Diochot,Anne Baronet al. Nature Neuroscience, 2007, 10 (8), pp.943-945. ⟨10.1038/nn1940⟩ Article dans une revue hal-00171736v1
Alpha-Linolenic acid and riluzole treatment confer cerebral protection and improve survival after focal brain ischemia C. Heurteaux,C. Laigle,N. Blondeau,G. Jarretou,M. Lazdunski Neuroscience, 2006, 137, pp.241-251 Article dans une revue hal-00091215v1
Les acides gras essentiels de la famille des oméga-3 et la santé de la mère et de l'enfant Nicolas Blondeau,Stéphane M. Schneider Nutrition Clinique et Métabolisme, 2006, 20 (2), pp.68-72. ⟨10.1016/j.nupar.2006.04.008⟩ Article dans une revue istex hal-02266269v1
Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype C. Heurteaux,G. Lucas,N. Guy,Malika El Yacoubi,S. Thümmleret al. Nature Neuroscience, 2006, 9, pp.1134-1141. ⟨10.1038/nn1749⟩ Article dans une revue hal-00091223v1
TREK-1, a K+ channel involved in polymodal pain perception. A. Alloui,K. Zimmermann,J. Mamet,Frederic Duprat,J. Noëlet al. EMBO Journal, 2006, 25, pp.2368-2376 Article dans une revue hal-00091208v1
Le rôle majeur du canal potassique TREK-1 dans la protection neuronale induite par les oméga-3 Catherine Heurteaux,Nicolas Blondeau Oléagineux, Corps Gras, Lipides, 2005, 12 (1), pp.68-77. ⟨10.1051/ocl.2005.0068⟩ Article dans une revue hal-02266268v1
Le role majeur du canal potassique TREK-1 dans la protection neuronale induite par les omega-3 C. Heurteaux,N. Blondeau OCL, 2005, xx, pp.77 Article dans une revue hal-00091446v1
Cerebral Tolerance: a new challenge to identify targets for cerebral protection N. Blondeau,C. Heurteaux Médecine/Sciences, 2004, 20, pp.1109-1114 Article dans une revue hal-00091456v1
Vascular sphingosine-1-phosphate S1P(1) and S1P(3) receptors C. Waeber,N. Blondeau,S. Salomone Drug News perspect., 2004, xx, pp.382 Article dans une revue hal-00091448v1
TREK-1, a K+ channel involved in neuroprotection and general anaesthesia C. Heurteaux,N. Guy,C. Laigle,N. Blondeau,M. Mazzucaet al. EMBO Journal, 2004, 23, pp.2684-2695 Article dans une revue hal-00091468v1
Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors Christian Waeber,Nicolas Blondeau,Salvatore Salomone Drug News perspect., 2004, 17 Article dans une revue hal-02266274v1
TREK-1, a K+ channel involved in neuroprotection and general anesthesia C. Heurteaux,N. Guy,C. Laigle,N. Blondeau,Frederic Dupratet al. EMBO Journal, 2004, 23 (13), pp.2684-2695. ⟨10.1038/sj.emboj.7600234⟩ Article dans une revue hal-02266418v1
Cerebral tolerance: a new challenge to identify targets for cerebral protection Nicolas Blondeau,Catherine Heurteaux Médecine/Sciences, 2004, 20 (12), pp.1109-1114. ⟨10.1051/medsci/200420121109⟩ Article dans une revue hal-02266270v1
Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats Loïc Lang-Lazdunski,Nicolas Blondeau,Gisele Jarretou,Michel Lazdunski,Catherine Heurteaux Journal of Vascular Surgery, 2003, 38 (3), pp.564-575. ⟨10.1016/S0741-5214(03)00473-7⟩ Article dans une revue hal-02266277v1
Linolenic acid prevents neuronal cell death and paraplegia following transient spinal cord ischemia in rats L. Lang-Lazdunski,N. Blondeau,G. Jarretou,M. Lazdunski,C. Heurteaux Journal of Vascular Surgery, 2003, 38, pp.564-575 Article dans une revue hal-00090986v1
A potent protective role of lysophospholipids against global cerebral ischemia and glutamate-excitotoxicity in neuronal cultures N. Blondeau,I. Lauritzen,C. Widmann,M. Lazdunski,C. Heurteaux Journal of Cerebral Blood Flow and Metabolism, 2002, 22, pp.821-834 Article dans une revue hal-00090913v1
Polyunsaturated fatty acids induce ischemic and epileptic tolerance N. Blondeau,C. Widmann,M. Lazdunski,C. Heurteaux Neuroscience, 2002, 109, pp.231-241 Article dans une revue hal-00090948v1
POLYUNSATURATED FATTY ACIDS INDUCE ISCHEMIC AND EPILEPTIC TOLERANCE N. Blondeau,C Widmann,M. Lazdunski,C. Heurteaux Neuroscience, 2002, 109 (2), pp.231-241. ⟨10.1016/s0306-4522(01)00473-0⟩ Article dans une revue istex hal-02266275v1
ATP-sensitive potassium channels (K ) in retina: a key role for ATP delayed ischemic tolerance Mohamed Ettaiche,Catherine Heurteaux,Nicolas Blondeau,Marc Borsotto,Norbert Tinelet al. Brain Research, 2001, 890 (1), pp.118 - 129. ⟨10.1016/s0006-8993(00)03152-8⟩ Article dans une revue istex hal-02266411v1
Activation of the Nuclear Factor-κB Is a Key Event in Brain Tolerance Nicolas Blondeau,Catherine Widmann,Michel Lazdunski,Catherine Heurteaux Journal of Neuroscience, 2001, 21 (13), pp.4668-4677. ⟨10.1523/JNEUROSCI.21-13-04668.2001⟩ Article dans une revue hal-02266280v1
K ATP CHANNEL OPENERS, ADENOSINE AGONISTS AND EPILEPTIC PRECONDITIONING ARE STRESS SIGNALS INDUCING HIPPOCAMPAL NEUROPROTECTION N. Blondeau,H Plamondon,C Richelme,C. Heurteaux,M Lazdunski² Neuroscience, 2000, 100 (3), pp.465-474. ⟨10.1016/S0306-4522(00)00304-3⟩ Article dans une revue istex hal-02266281v1
Polyunsaturated fatty acids are potent neuroprotectors Inger Lauritzen,Nicolas Blondeau,Catherine Heurteaux,Catherine Widmann,Georges Romeyet al. EMBO Journal, 2000, 19 (8), pp.1784-1793. ⟨10.1093/emboj/19.8.1784⟩ Article dans une revue hal-02266283v1
Mutually Protective Actions of Kainic Acid Epileptic Preconditioning and Sublethal Global Ischemia on Hippocampal Neuronal Death: Involvement of Adenosine A 1 Receptors and K ATP Channels Hélène Plamondon,Nicolas Blondeau,Catherine Heurteaux,Michel Lazdunski Journal of Cerebral Blood Flow and Metabolism, 1999, 19 (12), pp.1296-1308. ⟨10.1097/00004647-199912000-00002⟩ Article dans une revue hal-02266284v1