Nicolas FLOQUET

Publications

Article dans une revue (43)

Unveiling G-Protein-Coupled Receptor Conformational Dynamics via Metadynamics Simulations and Markov State Models Rita Ann Roessner,Nicolas Floquet,Maxime Louet Journal of Chemical Information and Modeling, 2025, 65 (9), pp.4630-4642. ⟨10.1101/2025.01.21.634062⟩ Article dans une revue hal-04922565v1
Extended Sampling of Macromolecular Conformations from Uniformly Distributed Points on Multidimensional Normal Mode Hyperspheres Antoniel A S. Gomes,Mauricio G S Costa,Maxime Louet,Nicolas Floquet,Paulo M Bischet al. Journal of Chemical Theory and Computation, 2024, 20 (24), pp.10770-10786. ⟨10.1021/acs.jctc.4c01054⟩ Article dans une revue hal-05127915v1
Sodium is a negative allosteric regulator of the ghrelin receptor Guillaume Ferré,Antoniel A.S. Gomes,Maxime Louet,Marjorie Damian,Paulo Bischet al. Cell Reports, 2023, 42 (4), pp.112320. ⟨10.1016/j.celrep.2023.112320⟩ Article dans une revue hal-04265315v1
MDexciteR: Enhanced Sampling Molecular Dynamics by Excited Normal Modes or Principal Components Obtained from Experiments Mauricio Costa,Paulo R Batista,Antoniel Gomes,Leonardo S Bastos,Maxime Louetet al. Journal of Chemical Theory and Computation, 2023, 19 (2), pp.412-425. ⟨10.1021/acs.jctc.2c00599⟩ Article dans une revue hal-04277555v1
Allosteric modulation of ghrelin receptor signaling by lipids Marjorie Damian,Maxime Louet,Antoniel Augusto Severo Gomes,Céline M’kadmi,Séverine Denoyelleet al. Nature Communications, 2021, 12 (1), pp.3938. ⟨10.1038/s41467-021-23756-y⟩ Article dans une revue hal-03407522v1
Cryo–electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex Julien Bous,Hélène Orcel,Nicolas Floquet,Cédric Leyrat,Josephine Lai Kee Himet al. Science Advances , 2021, 7 (21), pp.eabg5628. ⟨10.1126/sciadv.abg5628⟩ Article dans une revue hal-03240488v1
Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor Maxime Louet,Marina Casiraghi,Marjorie Damian,Mauricio Gs Costa,Pedro Renaultet al. eLife, 2021, 10, pp.e63201. ⟨10.7554/elife.63201⟩ Article dans une revue hal-03407524v1
Allosteric modulation of ghrelin receptor signaling by lipids Marjorie Damian,Maxime Louet,Antoniel Augusto Severo Gomes,Céline M’kadmi,Séverine Denoyelleet al. Nature Communications, 2021, 12 (1), pp.3938. ⟨10.1038/s41467-021-23756-y⟩ Article dans une revue hal-03852471v1
Molecular Dynamics Simulations of the Allosteric Modulation of the Adenosine A2a Receptor by a Mini-G Protein Pedro Renault,Maxime Louet,Jacky Marie,Gilles Labesse,Nicolas Floquet Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-41980-x⟩ Article dans une revue hal-02322127v1
Structure and dynamics of G protein-coupled receptor–bound ghrelin reveal the critical role of the octanoyl chain Guillaume Ferré,Maxime Louet,Oliver Saurel,Bartholomé Delort,Georges Czaplickiet al. Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (35), pp.17525-17530. ⟨10.1073/pnas.1905105116⟩ Article dans une revue hal-02322092v1
GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation Marjorie Damian,Véronique Pons,Pedro Renault,Céline M’kadmi,Bartholomé Delortet al. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (17), pp.4501-4506. ⟨10.1073/pnas.1712725115⟩ Article dans une revue hal-02322168v1
Structure and Dynamics of the Receptor-Bound Ghrelin Lipopeptide Guillaume Ferré,Marjorie Damian,Céline M'Kadmi,Olivier Saurel,Georges Czaplickiet al. Biophysical Journal, 2018, 114 (3), pp.235a. ⟨10.1016/J.BPJ.2017.11.1308⟩ Article dans une revue hal-02405941v1
Crystal structure and functional domains of the Mambaquaretin-1, a vasopressin type 2 receptor peptide inhibitor for kidney cysts treatment Laura Droctové,Justyna Ciolek,Manon Lancien,Enrico Stura,Laura Veraet al. Toxicon, 2018, 149, pp.91-92. ⟨10.1016/j.toxicon.2017.12.021⟩ Article dans une revue istex hal-03572739v1
Coarse-Grained Prediction of Peptide Binding to G-Protein Coupled Receptors Bartholomé Delort,Pedro Renault,Landry Charlier,Florent Raussin,Jean Martinezet al. Journal of Chemical Information and Modeling, 2017, 57 (3), pp.562-571. ⟨10.1021/acs.jcim.6b00503⟩ Article dans une revue hal-02322212v1
Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues Roberto Fanelli,Nicolas Floquet,Élie Besserer-Offroy,Bartholomé Delort,Mélanie Vivancoset al. Journal of Medicinal Chemistry, 2017, 60 (8), pp.3303-3313. ⟨10.1021/acs.jmedchem.6b01848⟩ Article dans une revue hal-02322191v1
Structural and Molecular Determinants of Membrane Binding by the HIV-1 Matrix Protein Peter Mercredi,Nadine Bucca,Burk Loeliger,Christy Gaines,Mansi Mehtaet al. Journal of Molecular Biology, 2016, 428 (8), pp.1637-1655. ⟨10.1016/j.jmb.2016.03.005⟩ Article dans une revue hal-02322236v1
Conformational Equilibrium of CDK/Cyclin Complexes by Molecular Dynamics with Excited Normal Modes Nicolas Floquet,Mauricio g.S. Costa,Paulo r. Batista,Pedro Renault,Paulo m. Bischet al. Biophysical Journal, 2015, 109 (6), pp.1179-1189. ⟨10.1016/j.bpj.2015.07.003⟩ Article dans une revue hal-02322259v1
Identification of TAX2 peptide as a new unpredicted anti-cancer agent Albin Jeanne,Emilie Sick,Jerôme Devy,Nicolas Floquet,N. Belloyet al. Oncotarget, 2015, 6, pp.17981-18000. ⟨10.18632/oncotarget.4025⟩ Article dans une revue hal-01280451v1
Coarse-Grained Simulations of the HIV-1 Matrix Protein Anchoring: Revisiting Its Assembly on Membrane Domains. Landry Charlier,Maxime Louet,Laurent Chaloin,Patrick Fuchs,Jean Martinezet al. Biophysical Journal, 2014, 106 (3), pp.577-585. ⟨10.1016/j.bpj.2013.12.019⟩ Article dans une revue hal-01105330v1
Interaction between the elastin peptide VGVAPG and human elastin binding protein. Charlotte Blanchevoye,Nicolas Floquet,Amandine Scandolera,Stéphanie Baud,Pascal Mauriceet al. Journal of Biological Chemistry, 2013, 288 (2), pp.1317-1328. ⟨10.1074/jbc.M112.419929⟩ Article dans une revue hal-01109325v1
Interaction between the Elastin Peptide VGVAPG and Human Elastin Binding Protein Charlotte Blanchevoye,Nicolas Floquet,Amandine Scandolera,Stéphanie Baud,Pascal Mauriceet al. Journal of Biological Chemistry, 2013, 288 (2), pp.1317-1328. ⟨10.1074/jbc.M112.419929⟩ Article dans une revue hal-02347668v1
Design of thrombospondin-binding peptides exhibiting strong anti- angiogenesis and anti-tumor properties A. Jeanne,E. Sick,C. Schneider,Nicolas Floquet,J. Devyet al. FEBS Journal, 2013, 280 (S1), pp.307-307. ⟨10.1111/febs.12340⟩ Article dans une revue hal-03574560v1
Conformational restriction of G-proteins Coupled Receptors (GPCRs) upon complexation to G-proteins: A putative activation mode of GPCRs? Maxime Louet,Esra Karakas,Alexandre Perret,David Perahia,Jean Martinezet al. FEBS Letters, 2013, 587 (16), pp.2656-2661. ⟨10.1016/j.febslet.2013.06.052⟩ Article dans une revue hal-01107226v1
GDP release preferentially occurs on the phosphate side in heterotrimeric G-proteins. Maxime Louet,Jean Martinez,Nicolas Floquet PLoS Computational Biology, 2012, 8 (7), pp.e1002595. ⟨10.1371/journal.pcbi.1002595⟩ Article dans une revue hal-01109342v1
Dissociation of Membrane-Anchored Heterotrimeric G-Protein Induced by Gα Subunit Binding to GTP. Maxime Louet,Landry Charlier,Jean Martinez,Nicolas Floquet Journal of Chemical Information and Modeling, 2012, 52 (11), pp.3022-3027. ⟨10.1021/ci3003717⟩ Article dans une revue hal-01109335v1
Chemical optimization of new ligands of the low-density lipoprotein receptor as potential vectors for central nervous system targeting. Jean-Daniel Malcor,Nadine Payrot,Marion David,Aude Faucon,Karima Abouzidet al. Journal of Medicinal Chemistry, 2012, 55 (5), pp.2227-41. ⟨10.1021/jm2014919⟩ Article dans une revue hal-00839126v1
Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor. Sophie Mary,Marjorie Damian,Maxime Louet,Nicolas Floquet,Jean-Alain Fehrentzet al. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (21), pp.8304-9. ⟨10.1073/pnas.1119881109⟩ Article dans une revue hal-00713574v1
L-Arginine Binding to Human Inducible Nitric Oxide Synthase: An Antisymmetric Funnel Route toward Isoform-Specific Inhibitors? Nicolas Floquet,Jean-François Hernandez,Jean-Luc Boucher,Jean Martinez Journal of Chemical Information and Modeling, 2011, 51, pp.1325-1335. ⟨10.1021/ci100422v⟩ Article dans une revue hal-00770855v1
A Concerted Mechanism for Opening the GDP Binding Pocket and Release of the Nucleotide in Hetero-Trimeric G-Proteins Maxime Louet,David Perahia,Jean Martinez,Nicolas Floquet Journal of Molecular Biology, 2011, 411, pp.296-312. ⟨10.1016/j.jmb.2011.05.034⟩ Article dans une revue istex hal-00771168v1
The YSNSG cyclopeptide derived from tumstatin inhibits tumor angiogenesis by down-regulating endothelial cell migration. Jessica Thevenard,Laurent Ramont,Jérome Devy,Bertrand Brassart,Aurélie Dupont-Deshorgueet al. International Journal of Cancer Supplement, 2010, 126 (5), pp.1055-1066. ⟨10.1002/ijc.24688⟩ Article dans une revue hal-01109849v1
Activation of the Ghrelin Receptor is Described by a Privileged Collective Motion: A Model for Constitutive and Agonist-induced Activation of a Sub-class A G-Protein Coupled Receptor (GPCR) Nicolas Floquet,C. Mikadmi,D. Perahia,Didier Gagne,Gilbert Bergeet al. Journal of Molecular Biology, 2010, 395 (4), pp.769-784. ⟨10.1016/j.jmb.2009.09.051⟩ Article dans une revue istex hal-00485751v1
The YSNSG cyclopeptide derived from tumstatin inhibits tumor angiogenesis by down-regulating endothelial cell migration Jessica Thévenard,Laurent Ramont,Bertrand Brassart,Aurélie Dupont-Deshorgue,Nicolas Floquetet al. International Journal of Cancer, 2010, 126 (5), pp.1055-1066 Article dans une revue hal-00771934v1
Involvement of tryptophan W276 and of two surrounding amino acid residues in the high constitutive activity of the ghrelin receptor GHS-R1a C. Goze,Gilbert Berge,Celine M\'Kadmi,Nicolas Floquet,Didier Gagneet al. European Journal of Pharmacology Molecular Pharmacology, 2010, 643 (2-3), pp.153-161. ⟨10.1016/j.ejphar.2010.06.018⟩ Article dans une revue istex hal-00583009v1
The spirocyclopropyl moiety as a methyl surrogate in the structure of L-fucosidase and L-rhamnosidase inhibitors Morwenna Pearson,Nicolas Floquet,Claudia Bello,Pierre Vogel,Richard Plantier-Royonet al. Bioorganic and Medicinal Chemistry, 2009, 17 (23), pp.8020-8026. ⟨10.1016/j.bmc.2009.10.010⟩ Article dans une revue hal-00439568v1
Collective motions in glucosamine-6-phosphate synthase: influence of ligand binding and role in ammonia channelling and opening of the fructose-6-phosphate binding site. Nicolas Floquet,Philippe Durand,Bernard Maigret,Bernard Badet,Marie-Ange Badet-Denisotet al. Journal of Molecular Biology, 2009, 385 (2), pp.653-664. ⟨10.1016/j.jmb.2008.10.032⟩ Article dans une revue istex hal-00365799v1
The role of aspartyl-rich pentapeptides in comparative complexation of actinide(IV) and iron(III). Part 1 Aurélie Jeanson,Claude Berthon,S. Coantic,Christophe den Auwer,Nicolas Floquetet al. New Journal of Chemistry, 2009, 33 (5), pp.976-985. ⟨10.1039/B813523A⟩ Article dans une revue istex hal-00583012v1
Expanding the borononucleotide family: synthesis of borono-analogues of dCMP, dGMP and dAMP. Anthony R. Martin,Kishor Mohanan,Delphine Luvino,Nicolas Floquet,Carine Baragueyet al. Organic & Biomolecular Chemistry, 2009, 7 (21), pp.4369-4377. ⟨10.1039/b912616c⟩ Article dans une revue istex hal-01109915v1
Human thrombospondin’s (TSP-1) C-terminal domain opens to interact with the CD-47 receptor: A molecular modeling study Nicolas Floquet,Stéphane Dedieu,Laurent Martiny,Manuel Dauchez,David Perahia Archives of Biochemistry and Biophysics, 2008, 478 (1), pp.103-109. ⟨10.1016/j.abb.2008.07.015⟩ Article dans une revue istex hal-01109933v1
Expression and purification of active human internal His6-tagged l-glutamine: d-Fructose-6P amidotransferase I Celine Richez,Joachim Boetzel,Nicolas Floquet,Kinnera Koteshwar,Julie Stevenset al. Protein Expression and Purification, 2007, 54 (1), pp.45-53. ⟨10.1016/j.pep.2007.01.015⟩ Article dans une revue istex hal-02144676v1
Discovery new inhibitors of bacterial glucosamine-6P synthase (GlmS) by docking simulations Nicolas Floquet,C. Richez,P. Durand,Bernard Maigret,B. Badetet al. Bioorganic and Medicinal Chemistry Letters, 2007, 17 (7), pp.1966-1970. ⟨10.1016/j.bmcl.2007.01.052⟩ Article dans une revue istex hal-00146254v1
Ammonia channeling in bacterial glucosamine-6-phosphate synthase (Glms): Molecular dynamics simulations and kinetic studies of protein mutants. Nicolas Floquet,Stéphane Mouilleron,Rasha Daher,Bernard Maigret,Bernard Badetet al. FEBS Letters, 2007, 581 (16), pp.2981-7. ⟨10.1016/j.febslet.2007.05.068⟩ Article dans une revue istex hal-00161331v1
Structural and antitumor properties of the YSNSG cyclopeptide derived from Tumstatin Jessica Thévenard,Nicolas Floquet,Laurent Ramont,Elise Prost,Jean-Marc Nuzillardet al. Chemistry and Biology, 2006, 13, pp.1307-1315 Article dans une revue hal-00134047v1
Elastin as a matrikine Laurent Duca,Nicolas Floquet,Alain J.P Alix,Bernard Haye,Laurent Debelle Critical Reviews in Oncology/Hematology, 2004, 49 (3), pp.235-244. ⟨10.1016/j.critrevonc.2003.09.007⟩ Article dans une revue istex hal-02330586v1

Communication dans un congrès (3)

An intricate link between membrane lipids and GPCR signaling Damian Marjorie,Michela Di Michele,Pauline Henri,Ludovic Berto,Maxime Louetet al. Symposium on GPCR Conformational Dynamics, Daniel Huster, Université de Leipzig, Jan 2025, Leipzig (DE), Germany Communication dans un congrès hal-04921963v1
Structure and dynamics of GPCR-bound ghrelin reveal the critical role of the octanoyl chain Guillaume Ferré,Maxime Louet,Oliver Saurel,Bartholomé Delort,Georges Czaplickiet al. Joint 12th EBSA congress and 10th ICBP – IUPAP Biophysics congress (EBSA-IUBAP 2019), European Biophysical Societies' Association (EBSA); International Union for Pure and Applied Biophysics (IUPAB); Sociedad de Biofísica de España, Jul 2019, Madrid, Spain Communication dans un congrès hal-04847921v1
Elastin in silico. Alain J.P. Alix,Brigida Bochicchio,Manuel Dauchez,Laurent Debelle,Philippe Derreumauxet al. Second European Symposium ELASTIN 2002, Jul 2002, Acquafredda di Maratea, Italy Communication dans un congrès hal-02333204v1

Pré-publication, Document de travail (2)

Lipids modulate the dynamics of gpcr:β-arrestin interaction Antoniel Gomes,Michela Di Michele,Rita Ann Roessner,Marjorie Damian,Paulo M Bischet al. 2024 Pré-publication, Document de travail (preprint/prepublication) hal-04790648v1
Structure of the antidiuretic hormone vasopressin receptor signalling complex. Julien Bous,Hélène Orcel,Nicolas Floquet,Cedric Leyrat,Josephine Lai-Kee-Himet al. 2020 Pré-publication, Document de travail hal-03088027v1

Autre publication scientifique (1)

Nos récepteurs déroulent leur mécanique ! Maxime Louet,Landry Charlier,Jean Martinez,Nicolas Floquet 2013, pp.380:26 Autre publication scientifique hal-01105310v1

Chapitre d'ouvrage (1)

Structure-function relationships of elastin-derived peptides: determination of a structural motif involved in the peptides-receptor(s) interactions. Nicolas Floquet,Laurent Duca,Stéphanie Héry-Hyunh,Gauthier Moroy,Manuel Dauchezet al. Elastin 2002, 2003 Chapitre d'ouvrage hal-02333101v1