Nicolas Lapaque

Identifiants chercheurs

IdHAL :

nicolas-lapaque

ORCID :

0000-0003-0824-0108

IdRef :

083490302

Publications

Article dans une revue (37)

Anorexia nervosa symptoms are induced after specific gut microbiota dysbiosis transfer in germ-free mice Tristan Gabriel-Segard,Christine Heberden,Stanislas Mondot,Maeva Duquesnoy,Marika Dicembreet al. Gut microbes, 2025, 17 (1), pp.2563701. ⟨10.1080/19490976.2025.2563701⟩ Article dans une revue hal-05418639v1
Deciphering the mechanisms of action underlying probiotic properties of Shouchella clausii by a functional genomics approach A. Lashermes,E. Mathieu,L. Marinelli,V. Léjard,E. Dervynet al. Beneficial Microbes, 2025, 16 (3), pp.347-362. ⟨10.1163/18762891-bja00050⟩ Article dans une revue hal-05322017v1
Adaptive immunity shapes innate and epithelial cell landscapes by silencing tonic IFN-γ in innate lymphoid cells during homeostasis Ousséma Mejri,Li Ma,Amneh Aoudi,Ossama Labiad,Stanislas Mondotet al. BioRxiv, In press, ⟨10.1101/2024.09.19.613869⟩ Article dans une revue hal-05401952v1
Role of pattern recognition receptors and microbiota-derived ligands in obesity Alice Rolland,Véronique Douard,Nicolas N. Lapaque Frontiers in Microbiomes, 2024, 3, ⟨10.3389/frmbi.2024.1324476⟩ Article dans une revue hal-04600251v1
Fusobacterium nucleatum promotes inflammatory and anti-apoptotic responses in colorectal cancer cells via ADP-heptose release and ALPK1/TIFA axis activation Camille Martin-Gallausiaux,Laurène Salesse,Diego Garcia-Weber,Ludovica Marinelli,Fabienne Beguet-Crespelet al. Gut microbes, 2024, 16 (1), pp.2295384. ⟨10.1080/19490976.2023.2295384⟩ Article dans une revue hal-04484107v1
An Insight into Functional Metagenomics: a High-Throughput Approach to Decipher Food–Microbiota–Host Interactions in the Human Gut Elliot Mathieu,Véronique Léjard,Chaima Ezzine,Pauline Govindin,Aurélien Moratet al. International Journal of Molecular Sciences, 2023, 24 (24), pp.17630. ⟨10.3390/ijms242417630⟩ Article dans une revue (article de synthèse) hal-04353544v1
Adlercreutzia equolifaciens Is an Anti-Inflammatory Commensal Bacterium with Decreased Abundance in Gut Microbiota of Patients with Metabolic Liver Disease Florian Plaza Oñate,Célia Chamignon,Sebastian Burz,Nicolas Lapaque,Magali Monnoyeet al. International Journal of Molecular Sciences, 2023, 24 (15), pp.12232. ⟨10.3390/ijms241512232⟩ Article dans une revue hal-04214482v1
Exposure to anti-seizure medications impact growth of gut bacterial species and subsequent host response Zehra Esra Ilhan,Vincent Brochard,Nicolas Lapaque,Stéphane Auvin,Patricia Lepage Neurobiology of Disease, 2022, 167, pp.105664. ⟨10.1016/j.nbd.2022.105664⟩ Article dans une revue hal-03954506v1
&lt;i&gt;Akkermansia muciniphila&lt;/i&gt; upregulates genes involved in maintaining the intestinal barrier function via ADP-heptose-dependent activation of the ALPK1/TIFA pathway Camille Martin-Gallausiaux,Diego Garcia-Weber,Amandine Lashermes,Pierre Larraufie,Ludovica Marinelliet al. Gut microbes, 2022, 14 (1), pp.2110639. ⟨10.1080/19490976.2022.2110639⟩ Article dans une revue hal-03787581v2
Short Chain Fatty Acids – mechanisms and functional importance in the gut Camille Martin-Gallausiaux,Ludovica Marinelli,Herve H. Blottiere,Pierre Larraufie,Nicolas Lapaque Proceedings of the Nutrition Society, 2021, 80 (1), pp. 37-49. ⟨10.1017/S0029665120006916⟩ Article dans une revue hal-02536149v1
Extracellular vesicles produced by the probiotic Propionibacterium freudenreichii CIRM-BIA 129 mitigate inflammation by modulating the NF-κB pathway Vinicius de Rezende Rodovalho,Brenda Silva Rosa da Luz,Houem Rabah,Fillipe Luiz Rosa Do Carmo,Edson L Foladoret al. Frontiers in Microbiology, 2020, 11, ⟨10.3389/fmicb.2020.01544⟩ Article dans une revue hal-02885846v1
Fructose malabsorption induces cholecystokinin expression in the ileum and cecum by changing microbiota composition and metabolism Xufei Zhang,Alexandra Grosfeld,Edek Williams,Daniel Vasiliauskas,Sharon Barrettoet al. FASEB Journal, 2019, 33 (6), pp.7126-7142. ⟨10.1096/fj.201801526RR⟩ Article dans une revue hal-02191008v1
Intestinal translocation of enterococci requires a threshold level of enterococcal overgrowth in the lumen Cristel Archambaud,Aurelie Derre-Bobillot,Nicolas Lapaque,Lionel Rigottier-Gois,Pascale Serror Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-45441-3⟩ Article dans une revue hal-02618379v1
Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells Ludovica Marinelli,Camille Martin-Gallausiaux,Jean-Marie Bourhis,Fabienne Beguet-Crespel,Herve Blottiereet al. Scientific Reports, 2019, 9 (1), pp.643. ⟨10.1038/s41598-018-37019-2⟩ Article dans une revue hal-01996381v1
Identification of New Factors Modulating Adhesion Abilities of the Pioneer Commensal Bacterium Streptococcus salivarius Benoit Couvigny,Saulius Kulakauskas,Nicolas Pons,Benoit Quinquis,Anne-Laure Abrahamet al. Frontiers in Microbiology, 2018, 9 (article 273), ⟨10.3389/fmicb.2018.00273⟩ Article dans une revue hal-01713777v1
SCFAs strongly stimulate PYY production in human enteroendocrine cells Pierre Larraufie,Camille Martin-Gallausiaux,Nicolas Lapaque,Joel Dore,F. M. Gribbleet al. Scientific Reports, 2018, 8, pp.1-9. ⟨10.1038/s41598-017-18259-0⟩ Article dans une revue hal-02628091v1
Butyrate produced by gut commensal bacteria activates TGF-beta1 expression through the transcription factor SP1 in human intestinal epithelial cells Camille Martin-Gallausiaux,Fabienne Beguet-Crespel,Ludovica Marinelli,Alexandre Jamet,Florence Ledueet al. Scientific Reports, 2018, 8, pp.1-13. ⟨10.1038/s41598-018-28048-y⟩ Article dans une revue hal-02624971v1
Butyrate produced by commensal bacteria down-regulates indolamine 2, 3-dioxygenase 1 (IDO-1) expression via a dual mechanism in human intestinal epithelial cells Camille Martin-Gallausiaux,Pierre Larraufie,Anne Jarry,Fabienne Beguet-Crespel,Ludovica Marinelliet al. Frontiers in Immunology, 2018, 9, ⟨10.3389/fimmu.2018.02838⟩ Article dans une revue inserm-01937996v1
The Enterococcus faecalis virulence factor ElrA interacts with the human Four-and-a-Half LIM Domains Protein 2 Alexandre Jamet,Rozenn Dervyn,Nicolas Lapaque,Francesca Bugli,Naima Bermudezet al. Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-04875-3⟩ Article dans une revue hal-01607001v1
Commensal gut bacteria modulate phosphorylation-dependent PPAR gamma transcriptional activity in human intestinal epithelial cells Malgorzata Nepelska,Tomas T. de Wouters,Elsa Jacouton,Fabienne Beguet-Crespel,Nicolas Lapaqueet al. Scientific Reports, 2017, 7, ⟨10.1038/srep43199⟩ Article dans une revue hal-02628360v1
TLR ligands and butyrate increase Pyy expression through two distinct but inter-regulated pathways Pierre Larraufie,Joel Dore,Nicolas Lapaque,Herve Blottiere Cellular Microbiology, 2017, 19 (2), ⟨10.1111/cmi.12648⟩ Article dans une revue hal-01530823v1
Three glycosylated serine-rich repeat proteins play a pivotal role in adhesion and colonization of the pioneer commensal bacterium, Streptococcus salivarius Benoit Couvigny,Nicolas Lapaque,Lionel Rigottier-Gois,Alain Guillot,Sophie Chatet al. Environmental Microbiology, 2017, 19 (9), pp.3579-3594. ⟨10.1111/1462-2920.13853⟩ Article dans une revue hal-01608428v1
The Salmonella effector SteD Mediates MARCH8-dependent ubiquitination of MHC II molecules and inhibits T cell activation Ethel Bayer-Santos,Charlotte H. Durkin,Luciano A. Rigano,Andreas Kupz,Eric Alixet al. Cell Host and Microbe, 2016, 20 (5), pp.584-595. ⟨10.1016/j.chom.2016.10.007⟩ Article dans une revue hal-01606854v1
Microorganisms linked to inflammatory bowel disease-associated dysbiosis differentially impact host physiology in gnotobiotic mice Thomas W Hoffmann,Hang-Phuong Pham,Chantal Bridonneau,Camille Aubry,Bruno Lamaset al. The International Society of Microbiologial Ecology Journal, 2016, 10 (2), pp.460-477. ⟨10.1038/ismej.2015.127⟩ Article dans une revue hal-01303788v1
Lactobacillus rhamnosus CNCMI-4317 Modulates Fiaf/Angptl4 in Intestinal Epithelial Cells and Circulating Level in Mice Elsa Jacouton,Núria Mach,Julie Cadiou,Nicolas Lapaque,Karine Clémentet al. PLoS ONE, 2015, 10 (10), pp.e0138880. ⟨10.1371/journal.pone.0138880⟩ Article dans une revue hal-01272988v1
Commensal [i]Streptococcus salivarius[/i] modulates PPARγ transcriptional activity in human intestinal epithelial cells Benoit Couvigny,Tomas de Wouters,Ghalia Kaci,Elsa Jacouton,Christine Delormeet al. PLoS ONE, 2015, 10 (5), ⟨10.1371/journal.pone.0125371⟩ Article dans une revue hal-01204466v1
Metagenomics of the human intestinal tract: from who is there to what is done there Antonietta Cultrone,Julien Tap,Nicolas Lapaque,Joël Doré,Herve H. Blottiere Current Opinion in Food Science, 2015, 4, pp.64-68. ⟨10.1016/j.cofs.2015.05.011⟩ Article dans une revue hal-02632823v1
A robust and adaptable high throughput screening method to study host-microbiota interactions in the human intestine Tomas de Wouters,Florence Ledue,Malgorzata Nepelska,Joel Dore,Herve Blottiereet al. PLoS ONE, 2014, 9 (8), ⟨10.1371/journal.pone.0105598⟩ Article dans une revue hal-01204452v1
ANGPTL4 expression induced by butyrate and rosiglitazone in human intestinal epithelial cells utilizes independent pathways Agata A. Korecka,Tomas T. de Wouters,Antonietta A. Cultrone,Nicolas N. Lapaque,Sven S. Petterssonet al. AJP - Gastrointestinal and Liver Physiology, 2013, 304 (11), pp.G1025 - G1037. ⟨10.1152/ajpgi.00293.2012⟩ Article dans une revue hal-01001518v1
The NF-kappa B binding site located in the proximal region of the TSLP promoter is critical for TSLP modulation in human intestinal epithelial cells Antonietta A. Cultrone,Tomas T. de Wouters,Omar O. Lakhdari,Denise D. Kelly,Imke I. Mulderet al. European Journal of Immunology, 2013, 43 (4), pp.1053 - 1062. ⟨10.1002/eji.201142340⟩ Article dans une revue hal-01001083v1
Enterococcus faecalis prophage dynamics and contributions to pathogenic traits Renata Filipa Cruz de Matos,Nicolas Lapaque,Lionel Rigottier-Gois,Laurent Debarbieux,Thierry Meylheucet al. PLoS Genetics, 2013, 9 (6), ⟨10.1371/journal.pgen.1003539⟩ Article dans une revue hal-01190746v1
HLA Class I Allelic Sequence and Conformation Regulate Leukocyte Ig-Like Receptor Binding Des C. Jones,Vasilis Kosmoliaptsis,Richard Apps,Nicolas Lapaque,Isobel Smithet al. Journal of Immunology, 2011, 186 (5), pp.2990 - 2997. ⟨10.4049/jimmunol.1003078⟩ Article dans une revue hal-01190489v1
Interactions between human NK cells and macrophages in response to Salmonella infection. Nicolas Lapaque,Thierry Walzer,Stéphane Méresse,Eric Vivier,John Trowsdale Journal of Immunology, 2009, 182 (7), pp.4339-48. ⟨10.4049/jimmunol.0803329⟩ Article dans une revue hal-00380263v1
Brucella abortus induces Irgm3 and Irga6 expression via type-I IFN by a MyD88-dependent pathway, without the requirement of TLR2, TLR4, TLR5 and TLR9. Nicolas Lapaque,Alexandre Muller,Lena Alexopoulou,Jonathan C Howard,Jean-Pierre Gorvel Microbial Pathogenesis, 2009, epub ahead of print. ⟨10.1016/j.micpath.2009.09.005⟩ Article dans une revue istex hal-00431861v1
Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1 Suzana P Salcedo,María Ines Marchesini,Hugues Lelouard,Emilie Fugier,Gilles Jollyet al. PLoS Pathogens, 2008, 4 (2), pp.e21. ⟨10.1371/journal.ppat.0040021⟩ Article dans une revue hal-00294210v1
Brucella lipopolysaccharide acts as a virulence factor. Nicolas Lapaque,Ignacio Moriyon,Edgardo Moreno,Jean-Pierre Gorvel Current Opinion in Microbiology, 2005, 8 (1), pp.60-6. ⟨10.1016/j.mib.2004.12.003⟩ Article dans une revue istex hal-00165710v1
Cyclic beta-1,2-glucan is a Brucella virulence factor required for intracellular survival. Beatriz Arellano-Reynoso,Nicolas Lapaque,Susana Salcedo,Gabriel Briones,Andrés Eduardo Ciocchiniet al. Nature Immunology, 2005, 6 (6), pp.618-25. ⟨10.1038/ni1202⟩ Article dans une revue istex hal-00165692v1

Communication dans un congrès (4)

Keynote Presentations - 1. An update on current methods for studying microbiome-host interactions in health and diseases Maxime Naour,Chaima Ezzine,Catherine Michel,Elliot Mathieu,Véronique Lejardet al. 16. International Symposium on Digestive Physiology of Pigs (DPP2025), May 2025, Lake Geneva, United States. pp.299-303, ⟨10.1016/j.anscip.2025.07.002⟩ Communication dans un congrès hal-05549822v1
ALPK1. Deletion protected from body weight gain and glucose intolerance induced by HFD Alice Rolland,Amandine Lashermes,Julie Cadiou,Stanislas Mondot,Véronique Douardet al. European Society for Clinical Nutrition and Metabolism, Sep 2022, Vienna, Austria Communication dans un congrès hal-04352091v1
&lt;em&gt;Propionibacterium freudenreichii&lt;/em&gt; secretes extracellular vesicles with anti-inflammatory activity via NF-κB pathway modulation Vinicius de Rezende Rodovalho,Brenda Silva Rosa da Luz,Fillipe Luiz Rosa Do Carmo,Herve Blottiere,Nicolas Lapaqueet al. 2. French Society of Extracellular Vesicles Congress, Oct 2019, Nantes, France Communication dans un congrès hal-02735885v1
Prophage-crosstalk and prophage-associated cytotoxicity in Enterococcus faecalis v583 Renata Filipa Cruz de Matos,Naima G Cortes-Perez,Nicolas N. Lapaque,Albertas Navickas,Thierry Meylheucet al. Journées des Microbiologistes de l’INRA, Nov 2012, L’Isle-sur-la-Sorgue, France Communication dans un congrès hal-03584441v1

Poster de conférence (3)

[i]Streptococcus thermophilus[/i] strains reduce expression of NF-κB in human intestinal epithelial cells Victoria Chuat,Sophie Bobet,Nicolas Lapaque,Herve Blottiere,Sylvie Lortalet al. FoodMicro 2016, Jul 2016, Dublin, Ireland. 2016 Poster de conférence hal-01349147v1
The three Serine rich Proteins encoded in the secA2Y2 system of the human commensal bacterium Streptococcus salivarius promotes binding to different targets of the host Benoit Couvigny,Romain Briandet,Celine Gautier,Lionel Rigottier-Gois,Manfred Rohdeet al. 7th international conference on Gram-positive microorganisms, Jun 2013, Montecatini, Italy. 2013 Poster de conférence hal-01454649v1
The commensal bacterium [i]Streptococcus salivarius[/i] inhibits PPARg activity and its target genes in human intestinal epithelial cells Benoit Couvigny,Tomas de Wouters,Ghalia Kaci,Christine Delorme,Joel Doreet al. IHMC, International Human Microbiome Congress : Paris 2012, Sep 2012, Paris, France. 2012 Poster de conférence hal-01359134v1