Nicolas Tchitchek

Identifiants chercheurs

IdHAL :

nicolas-tchitchek

ORCID :

0000-0003-3307-0446

IdRef :

161678300

VIAF :

281776371

ISNI :

0000000388611051

Présentation

Ma recherche se concentre sur la caractérisation des dysrégulations moléculaires, cellulaires et microbiennes dans les troubles auto-immuns et auto-inflammatoires, à la fois en état stable et en réponse aux immunothérapies, en utilisant des approches d'immunologie systémique.

Publications

Article dans une revue (89)

Prognostic factors and predictive model for severe multiple sclerosis at first onset in a pediatric French cohort Aliénor de Chalus,Gonzalo Barraza,Nicolas Tchitchek,Yahya Debza,Hélène Maureyet al. European Journal of Paediatric Neurology, 2026, 60, pp.71 - 77. ⟨10.1016/j.ejpn.2025.12.002⟩ Article dans une revue hal-05561847v1
Immune checkpoint-engineered virus-like particles induce antigen-specific immune tolerance and protect against food allergy Pierre-Axel Vinot,James Vigneron,Julie Marsande,Béatrice Levacher,Nicolas Tchitcheket al. NPJ vaccines, 2026, 11 (1), pp.43. ⟨10.1038/s41541-026-01379-y⟩ Article dans une revue hal-05561845v1
Immunologic Profiling Suggests an Association Between Treg Cell Dysfunction and Pain in Knee Osteoarthritis Marie Binvignat,Johanna Dubois,Maria Marco Salvador,Paul Stys,Fabien Pitoisetet al. Arthritis & rheumatology, 2026, Online ahead of print. ⟨10.1002/art.43437⟩ Article dans une revue hal-05561849v1
Low-dose interleukin-2 in patients with bipolar depression: A phase 2 randomised double-blind placebo-controlled trial Marion Leboyer,Marianne Foiselle,Nicolas Tchitchek,Ryad Tamouza,Roberta Lorenzonet al. Brain, Behavior, and Immunity, 2025, 123, pp.177-184. ⟨10.1016/j.bbi.2024.09.005⟩ Article dans une revue hal-05472377v1
IL-1β signaling modulates T follicular helper and regulatory cells in human lymphoid tissues Romain Vaineau,Raphaël Jeger-Madiot,Samir Ali-Moussa,Laura Prudhomme,Hippolyte Debarnotet al. JCI Insight, 2025, 10 (12), pp.e188724. ⟨10.1172/jci.insight.188724.⟩ Article dans une revue hal-05561617v1
BLIMP-1 and CEACAM1 cooperatively regulate human Treg homeostasis and function to control xenogeneic GVHD Ying Ding,Aixin Yu,Milos Vujanac,Sabrina Copsel,Alejandro Moroet al. JCI Insight, 2025, 10 (18), pp.e183676. ⟨10.1172/jci.insight.183676⟩ Article dans une revue hal-05561851v1
Interleukin-1 regulates follicular T cells during the germinal center reaction Aude Belbezier,Paul Engeroff,Gwladys Fourcade,Hélène Vantomme,Romain Vaineauet al. Frontiers in Immunology, 2024, 15, ⟨10.3389/fimmu.2024.1393096⟩ Article dans une revue hal-04997740v1
Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types Nicolas Tchitchek,Marie Binvignat,Alexandra Roux,Fabien Pitoiset,Johanna Duboiset al. Annals of the Rheumatic Diseases, 2024, ⟨10.1136/ard-2023-225179⟩ Article dans une revue hal-04490369v1
A randomized double-blind placebo-controlled trial of low-dose interleukin-2 in relapsing–remitting multiple sclerosis C Louapre,M Rosenzwajg,M Golse,A Roux,F Pitoisetet al. Journal of Neurology, 2023, 270, pp.4403 - 4414. ⟨10.1007/s00415-023-11690-6⟩ Article dans une revue hal-04490382v1
Maternal immune activation during pregnancy is associated with more difficulties in socio-adaptive behaviors in autism spectrum disorder Pierre Ellul,Anna Maruani,Valérie Vantalon,Élise Humeau,Anouck Amestoyet al. Scientific Reports, 2023, 13, pp.17687. ⟨10.1038/s41598-023-45060-z⟩ Article dans une revue hal-04605111v1
Early systemic inflammation induces neurodevelopmental disorders: results from ARTEMIS, a French multicenter study of juvenile rheumatisms and systemic autoimmune and auto-inflammatory disorders and meta-analysis Pierre Ellul,Isabelle Melki,Stephanie Antoun,Laura Lavialle,Eric Acquavivaet al. Molecular Psychiatry, 2023, ⟨10.1038/s41380-023-01980-w⟩ Article dans une revue hal-03985785v1
Naive and memory CD4 + T cell subsets can contribute to the generation of human Tfh cells Raphaël Jeger-Madiot,Romain Vaineau,Maud Heredia,Nicolas Tchitchek,Lisa Bertrandet al. iScience, 2022, 25 (1), pp.103566. ⟨10.1016/j.isci.2021.103566⟩ Article dans une revue hal-03854774v2
The route of vaccine administration determines whether blood neutrophils undergo long-term phenotypic modifications Yanis Feraoun,Jean-Louis Palgen,Candie Joly,Nicolas Tchitchek,Ernesto Marcos-Lopezet al. Frontiers in Immunology, 2022, 12, pp.784813. ⟨10.3389/fimmu.2021.784813⟩ Article dans une revue hal-03787905v1
Long‐term outcome of paediatric &lt;scp&gt;anti‐&lt;i&gt;N&lt;/i&gt;‐methyl‐D&lt;/scp&gt;&lt;scp&gt;‐&lt;/scp&gt;aspartate receptor encephalitis Lorraine Flet‐berliac,Nicolas Tchitchek,Anne Lépine,Anca Florea,Hélène Maureyet al. Developmental Medicine and Child Neurology - Developmental Medicine & Child Neurology, 2022, 65, pp.691 - 700. ⟨10.1111/dmcn.15429⟩ Article dans une revue hal-04490426v1
Long-term outcome of paediatric anti-N-methyl-D-aspartate receptor encephalitis. Lorraine Flet-Berliac,Nicolas Tchitchek,Anne Lépine,Anca Florea,Hélène Maureyet al. Developmental Medicine and Child Neurology - Developmental Medicine & Child Neurology, 2022, ⟨10.1111/dmcn.15429⟩ Article dans une revue hal-03960996v1
The Tsallis generalized entropy enhances the interpretation of transcriptomics datasets Nicolas Dérian,Hang-Phuong Pham,Djamel Nehar-Belaid,Nicolas Tchitchek,David Klatzmannet al. PLoS ONE, 2022, 17 (4), pp.e0266618. ⟨10.1371/journal.pone.0266618⟩ Article dans une revue hal-03854768v1
Identification of Symptoms Phenotypes of Hand Osteoarthritis using Hierarchical Clustering: Results from the &lt;scp&gt;DIGICOD&lt;/scp&gt; Cohort Marie Binvignat,Gabriel Pires,Nicolas Tchitchek,Félicie Costantino,Alice Courtieset al. Arthritis Care & Research = Arthritis Care and Research, In press, ⟨10.1002/acr.25047⟩ Article dans une revue hal-03843031v1
Low-dose IL-2 shapes a tolerogenic gut microbiota that improves autoimmunity and gut inflammation Nicolas Tchitchek,Otriv Nguekap Tchoumba,Gabriel Pires,Sarah Dandou,Julien Campagneet al. JCI Insight, 2022, 7 (17), ⟨10.1172/jci.insight.159406⟩ Article dans une revue hal-03797609v1
Naive and memory CD4+ T cell subsets can contribute to the generation of human Tfh cells Raphaël Jeger-Madiot,Romain Vaineau,Maud Heredia,Nicolas Tchitchek,Lisa Bertrandet al. iScience, 2022, 25 (1), pp.103566. ⟨10.1016/j.isci.2021.103566⟩ Article dans une revue hal-03977505v1
Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial Antoine Monsel,Caroline Hauw-Berlemont,Miryam Mebarki,Nicholas Heming,Julien Mayauxet al. Critical Care, 2022, 26 (1), ⟨10.1186/s13054-022-03930-4⟩ Article dans une revue hal-03604084v1
Role of NKG2a/c+CD8+ T cells in pathogenic versus non-pathogenic SIV infections Nicolas Huot,Philippe Rascle,Nicolas Tchitchek,Benedikt Wimmer,Caroline Passaeset al. iScience, 2021, 24 (4), pp.102314. ⟨10.1016/j.isci.2021.102314⟩ Article dans une revue hal-03225293v1
Vaccine Inoculation Route Modulates Early Immunity and Consequently Antigen-Specific Immune Response Pierre Rosenbaum,Nicolas Tchitchek,Candie Joly,André Rodriguez Pozo,Lev Stimmeret al. Frontiers in Immunology, 2021, 12, pp.645210. ⟨10.3389/fimmu.2021.645210⟩ Article dans une revue hal-03321921v1
Predictive Markers of Immunogenicity and Efficacy for Human Vaccines Matthieu van Tilbeurgh,Katia Lemdani,Anne-Sophie Beignon,Catherine Chapon,Nicolas Tchitcheket al. Vaccines, 2021, 9 (6), pp.579. ⟨10.3390/vaccines9060579⟩ Article dans une revue hal-03278510v1
Vaccine Inoculation Route Modulates Early Immunity and Consequently Antigen-Specific Immune Response Pierre Rosenbaum,Nicolas Tchitchek,Candie Joly,André Rodriguez Pozo,Lev Stimmeret al. Frontiers in Immunology, 2021, 12, ⟨10.3389/fimmu.2021.645210⟩ Article dans une revue hal-04489521v1
Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3'Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21 Erminia Rubino,Melania Cruciani,Nicolas Tchitchek,Anna Le Tortorec,Antoine Rollandet al. Frontiers in Genetics, 2021, 11, ⟨10.3389/fgene.2020.627007⟩ Article dans une revue hal-03154598v1
Leukocytospermia induces intraepithelial recruitment of dendritic cells and increases SIV replication in colorectal tissue explants Mariangela Cavarelli,Stéphane Hua,Naima Hantour,Sabine Tricot,Nicolas Tchitcheket al. Communications Biology, 2021, 4, ⟨10.1038/s42003-021-02383-9⟩ Article dans une revue hal-04510006v1
Leukocytospermia induces intraepithelial recruitment of dendritic cells and increases SIV replication in colorectal tissue explants Mariangela Cavarelli,Stéphane Hua,Naima Hantour,Sabine Tricot,Nicolas Tchitcheket al. Communications Biology, 2021, 4, pp.861. ⟨10.1038/s42003-021-02383-9⟩ Article dans une revue hal-03287057v1
Bacnet: a user-friendly platform for building multi-omics websites. Loane Danès,Nicolas Tchitchek,Christophe Bécavin Bioinformatics (Oxford, England), 2021, 37 (9), pp.1335--1336. ⟨10.1093/bioinformatics/btaa828⟩ Article dans une revue hal-03961011v1
DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infections Simon P. Jochems,Beatrice Jacquelin,Nicolas Tchitchek,Florence Busato,Fabien Pichonet al. Clinical Epigenetics, 2020, 12 (1), pp.188. ⟨10.1186/s13148-020-00971-w⟩ Article dans une revue hal-03225306v1
Innate Molecular and Cellular Signature in the Skin Preceding Long-Lasting T Cell Responses After Electroporated DNA Vaccination Lucille Adam,Nicolas Tchitchek,Biliana Todorova,Pierre Rosenbaum,Candie Jolyet al. Journal of Immunology, 2020, 204 (12), pp.3375-3388. ⟨10.4049/jimmunol.1900517⟩ Article dans une revue inserm-02869578v1
Innate Molecular and Cellular Signature in the Skin Preceding Long-Lasting T Cell Responses after Electroporated DNA Vaccination Lucille Adam,Nicolas Tchitchek,Biliana Todorova,Pierre Rosenbaum,Candie Jolyet al. The Journal of Immunology, 2020, 9 (12), pp.3375-3388. ⟨10.3389/fimmu.2018.00870⟩ Article dans une revue hal-04489426v1
Innate and secondary humoral responses are improved by increasing the time between MVA vaccine immunizations Jean-Louis Palgen,Nicolas Tchitchek,André Rodriguez-Pozo,Quentin Jouhault,Hadjer Abdelhouahabet al. NPJ vaccines, 2020, 5, ⟨10.1038/s41541-020-0175-8⟩ Article dans une revue hal-03079492v1
Mechanisms of innate events during skin reaction following intradermal injection of seasonal influenza vaccine Jessica Gonnet,Lauranne Poncelet,Celine Meriaux,Elena Gonçalves,Lina Weisset al. Journal of Proteomics, 2020, 216, pp.103670. ⟨10.1016/j.jprot.2020.103670⟩ Article dans une revue hal-03984601v2
Modulation of Cell Surface Receptor Expression by Modified Vaccinia Virus Ankara in Leukocytes of Healthy and HIV-Infected Individuals Adrien Leite Pereira,Quentin Jouhault,Ernesto Marcos Lopez,Antonio Cosma,Olivier Lambotteet al. Frontiers in Immunology, 2020, 11 (6), pp.579. ⟨10.3389/fimmu.2020.02096⟩ Article dans une revue hal-03960814v1
Salivary gland epithelial cells from patients with Sjögren's syndrome induce B-lymphocyte survival and activation Elodie Riviere,Juliette Pascaud,Nicolas Tchitchek,Saida Boudaoud,Audrey Paolettiet al. Annals of the Rheumatic Diseases, 2020, 79 (11), pp.1468-1477. ⟨10.1136/annrheumdis-2019-216588⟩ Article dans une revue inserm-03150054v1
Low-dose IL-2 in children with recently diagnosed type 1 diabetes: a Phase I/II randomised, double-blind, placebo-controlled, dose-finding study Michelle Rosenzwajg,Randa Salet,Roberta Lorenzon,Nicolas Tchitchek,Alexandra Rouxet al. Diabetologia, 2020, 63 (9), pp.1808-1821. ⟨10.1007/s00125-020-05200-w⟩ Article dans une revue hal-03345047v1
Interleukin‐7/Interferon axis drives T‐cell and salivary gland epithelial cell interactions in Sjögren’s syndrome Elodie Rivière,Juliette Pascaud,Alexandre Virone,Anastasia Dupré,Bineta Lyet al. Arthritis & rheumatology, 2020, 73 (4), pp.631-640. ⟨10.1002/art.41558⟩ Article dans une revue pasteur-03036519v1
Early blood transcriptomic signature predicts patients’ outcome after out-of-hospital cardiac arrest Renaud Tissier,Hakim Hocini,Nicolas Tchitchek,Nicolas Deye,Stéphane Legrielet al. Resuscitation, 2019, 138, pp.222 - 232. ⟨10.1016/j.resuscitation.2019.03.006⟩ Article dans une revue hal-03485659v1
Characterization of Leukocytes From HIV-ART Patients Using Combined Cytometric Profiles of 72 Cell Markers. Adrien Leite Pereira,Nicolas Tchitchek,Olivier Lambotte,Roger Le Grand,Antonio Cosma Frontiers in Immunology, 2019, 10, pp.1777. ⟨10.3389/fimmu.2019.01777⟩ Article dans une revue hal-03961014v1
CytoBackBone: an algorithm for merging of phenotypic information from different cytometric profiles. Adrien Leite Pereira,Olivier Lambotte,Roger Le Grand,Antonio Cosma,Nicolas Tchitchek Bioinformatics, 2019, 35 (20), pp.4187-4189. ⟨10.1093/bioinformatics/btz212⟩ Article dans une revue hal-03961015v1
Characterization of Phenotypes and Functional Activities of Leukocytes From Rheumatoid Arthritis Patients by Mass Cytometry. Adrien Leite Pereira,Samuel Bitoun,Audrey Paoletti,Gaetane Nocturne,Ernesto Marcos Lopezet al. Frontiers in Immunology, 2019, 10, pp.2384. ⟨10.3389/fimmu.2019.02384⟩ Article dans une revue hal-03961013v1
Cynomolgus macaque IL37 polymorphism and control of SIV infection Takashi Shiina,Shingo Suzuki,Nicolas Congy-Jolivet,Alice Aarnink,Henri-Jean Garchonet al. Scientific Reports, 2019, 9 (1), pp.7981. ⟨10.1038/s41598-019-44235-x⟩ Article dans une revue hal-02149363v1
Dynamics of Vaginal and Rectal Microbiota Over Several Menstrual Cycles in Female Cynomolgus Macaques Marie-Thérèse Nugeyre,Nicolas Tchitchek,Cindy Adapen,Claude Cannou,Vanessa Contreraset al. Frontiers in Cellular and Infection Microbiology, 2019, 9, pp.188. ⟨10.3389/fcimb.2019.00188⟩ Article dans une revue inserm-02433779v1
Progenitors from the central nervous system drive neurogenesis in cancer Philippe Mauffrey,Nicolas Tchitchek,Vilma Barroca,Alexis-Pierre Bemelmans,Virginie Firlejet al. Nature, 2019, 569 (7758), pp.672-678. ⟨10.1038/s41586-019-1219-y⟩ Article dans une revue hal-03987060v1
Innate gene signature distinguishes humoral versus cytotoxic responses to influenza vaccination Elena Gonçalves,Olivia Bonduelle,Angèle Soria,Pierre Loulergue,Alexandra Rousseauet al. The Journal of clinical investigation, 2019, 129 (5), pp.1960-1971. ⟨10.1172/jci125372⟩ Article dans une revue hal-03160706v1
NK cell immune responses differ after prime and boost vaccination Jean‐louis Palgen,Nicolas Tchitchek,Nicolas Huot,Jamila Elhmouzi-Younes,Cécile Lefebvreet al. Journal of Leukocyte Biology, 2019, 105 (5), pp.1055-1073. ⟨10.1002/JLB.4A1018-391RR⟩ Article dans une revue hal-02385954v1
Intradermal vaccination prevents anti-MOG autoimmune encephalomyelitis in macaques Claire-Maëlle Fovet,Lev Stimmer,Vanessa Contreras,Philippe Horellou,Audrey Hubertet al. EBioMedicine, 2019, 47, pp.492-505. ⟨10.1016/j.ebiom.2019.08.052⟩ Article dans une revue hal-02305565v1
Seminal Plasma Exposures Strengthen Vaccine Responses in the Female Reproductive Tract Mucosae Romain Marlin,Marie-Thérèse Nugeyre,Nicolas Tchitchek,Matteo Parenti,Cécile Lefebvreet al. Frontiers in Immunology, 2019, 10, pp.430. ⟨10.3389/fimmu.2019.00430⟩ Article dans une revue inserm-02433796v1
Progenitors from the central nervous system drive neurogenesis in cancer Philippe Mauffrey,Nicolas Tchitchek,Vilma Barroca,Alexis-Pierre Bemelmans,Virginie Firlejet al. Nature, 2019, 569 (7758), pp.672-678. ⟨10.1038/s41586-019-1219-y⟩ Article dans une revue cea-02186559v1
Mass Cytometry Analysis Reveals Complex Cell-State Modifications of Blood Myeloid Cells During HIV Infection Sixtine Coindre,Nicolas Tchitchek,Lamine Alaoui,Bruno Vaslin,Christine Bourgeoiset al. Frontiers in Immunology, 2019, ⟨10.3389/fimmu.2019.02677⟩ Article dans une revue hal-02386129v1
Anti-MOG autoantibodies pathogenicity in children and macaques demyelinating diseases Che Serguera,Lev Stimmer,Claire-Maëlle Fovet,Philippe Horellou,Vanessa Contreraset al. Journal of Neuroinflammation, 2019, 16, pp.244. ⟨10.1186/s12974-019-1637-7⟩ Article dans une revue cea-02397764v1
Navigating in the vast and deep oceans of high-dimensional biological data. Nicolas Tchitchek Methods (San Diego, Calif.), 2018, 132, pp.1--2. ⟨10.1016/j.ymeth.2017.11.009⟩ Article dans une revue hal-03961017v1
Molecular and Cellular Dynamics in the Skin, the Lymph Nodes, and the Blood of the Immune Response to Intradermal Injection of Modified Vaccinia Ankara Vaccine Pierre Rosenbaum,Nicolas Tchitchek,Candie Joly,Lev Stimmer,Hakim Hociniet al. Frontiers in Immunology, 2018, 9, ⟨10.3389/fimmu.2018.00870⟩ Article dans une revue hal-03984590v1
Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response Jean-Louis Palgen,Nicolas Tchitchek,Jamila Elhmouzi-Younes,Simon Delandre,Inana Nametet al. Scientific Reports, 2018, 8 (1), pp.3087. ⟨10.1038/s41598-018-21222-2⟩ Article dans une revue hal-03984523v1
Stage-specific IFN-induced and IFN gene expression reveal convergence of type I and type II IFN and highlight their role in both acute and chronic stage of pathogenic SIV infection Nadia Echebli,Nicolas Tchitchek,Stéphanie Dupuy,Timothée Bruel,Caroline Passaeset al. PLoS ONE, 2018, 13 (1), pp.e0190334. ⟨10.1371/journal.pone.0190334⟩ Article dans une revue hal-02861901v1
A high-resolution mass cytometry analysis reveals a delay of cytokines production after TLR4 or TLR7/8 engagements in HIV-1 infected humans Adrien Leite Pereira,Nicolas Tchitchek,Ernesto Marcos Lopez,Olivier Lambotte,Roger Le Grandet al. Cytokine, 2018, 111, pp.97 - 105. ⟨10.1016/j.cyto.2018.08.018⟩ Article dans une revue hal-03854788v1
Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response Jean-Louis Palgen,Nicolas Tchitchek,Jamila Elhmouzi-Younes,Simon Delandre,Inana Nametet al. Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-21222-2⟩ Article dans une revue hal-02385941v1
Mass Cytometry Analysis Reveals the Landscape and Dynamics of CD32a+ CD4+ T Cells From Early HIV Infection to Effective cART Sixtine Coindre,Nicolas Tchitchek,Lamine Alaoui,Bruno Vaslin,Christine Bourgeoiset al. Frontiers in Immunology, 2018, 9, ⟨10.3389/fimmu.2018.01217⟩ Article dans une revue hal-02386113v1
Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response Jean-Louis Palgen,Nicolas Tchitchek,Jamila Elhmouzi-Younes,Simon Delandre,Inana Nametet al. Scientific Reports, 2018, 8 (1), pp.3087. ⟨10.1038/s41598-018-21222-2⟩ Article dans une revue hal-04489471v1
Molecular and cellular Dynamics in the skin, the lymph nodes, and the Blood of the immune response to intradermal injection of Modified Vaccinia ankara Vaccine Pierre Rosenbaum,Nicolas Tchitchek,Candie Joly,Lev Stimmer,Hakim Hociniet al. Frontiers in Immunology, 2018, 9, pp.870. ⟨10.3389/fimmu.2018.00870⟩ Article dans une revue hal-02386077v1
Modified Vaccinia Virus Ankara Vector Induces Specific Cellular and Humoral Responses in the Female Reproductive Tract, the Main HIV Portal of Entry Romain Marlin,Marie-Thérèse Nugeyre,Nicolas Tchitchek,Matteo Parenti,Hakim Hociniet al. Journal of Immunology, 2017, 199 (5), pp.1923 - 1932. ⟨10.4049/jimmunol.1700320⟩ Article dans une revue pasteur-01597708v1
A computational approach for phenotypic comparisons of cell populations in high-dimensional cytometry data Ludovic Platon,David Pejoski,Guillaume Gautreau,Brice Targat,Roger Le Grandet al. MethodsX, 2017, ⟨10.1016/j.ymeth.2017.09.005⟩ Article dans une revue hal-02386051v1
In depth comparative phenotyping of blood innate myeloid leukocytes from healthy humans and macaques using mass cytometry. Jamila Elhmouzi-Younes,Jean-Louis Palgen,Nicolas Tchitchek,Simon Delandre,Inana Nametet al. Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2017, 91 (10), pp.969--982. ⟨10.1002/cyto.a.23107⟩ Article dans une revue hal-03961018v1
Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus. Pierre Roques,Karl Ljungberg,Beate M. Kümmerer,Leslie Gosse,Nathalie Dereuddre-Bosquetet al. JCI Insight, 2017, 2 (6), pp.e83527. ⟨10.1172/jci.insight.83527⟩ Article dans une revue hal-03961019v1
Listeriomics : an Interactive Web Platform for Systems Biology of Listeria Christophe Bécavin,Mikael Koutero,Nicolas Tchitchek,Franck Cerutti,Pierre Lechatet al. mSystems, 2017, 2 (2), pp.e00186-16. ⟨10.1128/mSystems.00186-16⟩ Article dans une revue pasteur-01574970v1
SPADEVizR: an R package for Visualization, Analysis and Integration of SPADE results Guillaume Gautreau,David Pejoski,Roger Le Grand,Antonio Cosma,Anne-Sophie Beignonet al. Bioinformatics, 2017, pp.btw708. ⟨10.1093/bioinformatics/btw708⟩ Article dans une revue hal-02385937v1
Analysis methodology and development of a statistical tool for biodistribution data from internal contamination with actinides Stephanie Lamart,Nina Griffiths,Nicolas Tchitchek,Jaime Angulo,Anne van der Meeren Journal of Radiological Protection, 2017, 37 (1), pp.296-308. ⟨10.1088/1361-6498/37/1/296⟩ Article dans une revue hal-03856452v1
Erythropoietin Levels Increase during Cerebral Malaria and Correlate with Heme, Interleukin-10 and Tumor Necrosis Factor-Alpha in India E. Dalko,N. Tchitchek,Laurent Pays,F. Herbert,P. A. Cazenaveet al. PLoS ONE, 2016, 11 (7), pp.e0158420. ⟨10.1371/journal.pone.0158420⟩ Article dans une revue hal-01850300v1
Identification of Vaccine-Altered Circulating B Cell Phenotypes Using Mass Cytometry and a Two-Step Clustering Analysis. David Pejoski,Nicolas Tchitchek,André Rodriguez Pozo,Jamila Elhmouzi-Younes,Rahima Yousfi-Bogniahoet al. Journal of immunology (Baltimore, Md. : 1950), 2016, 196 (11), pp.4814--4831. ⟨10.4049/jimmunol.1502005⟩ Article dans une revue hal-03961021v1
The 1918 influenza virus PB2 protein enhances virulence through the disruption of inflammatory and Wnt-mediated signaling in mice Adriana Forero,Jennifer Tisoncik-Go,Tokiko Watanabe,Gongxun Zhong,Masato Hattaet al. Journal of Virology, 2016, 90 (5), pp.2240-2253. ⟨10.1128/JVI.02974-15⟩ Article dans une revue hal-03851553v1
Myocardial Gene Expression Profiling to Predict and Identify Cardiac Allograft Acute Cellular Rejection: The GET-Study Diane Bodez,Hakim Hocini,Nicolas Tchitchek,Pascaline Tisserand,Nicole Benhaiemet al. PLoS ONE, 2016, 11 (11), pp.e0167213. ⟨10.1371/journal.pone.0167213⟩ Article dans une revue hal-03987039v1
Delayed Inflammatory and Cell Death Responses Are Associated with Reduced Pathogenicity in Lujo Virus-Infected Cynomolgus Macaques Angela L Rasmussen,Nicolas Tchitchek,David Safronetz,Victoria S Carter,Christopher M Williamset al. Journal of Virology, 2015, 89 (5), pp.2543 - 2552. ⟨10.1128/jvi.02246-14⟩ Article dans une revue hal-03851569v1
Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria. Fabien Herbert,Nicolas Tchitchek,Devendra Bansal,Julien Jacques,Sulabha Pathaket al. Journal of Translational Medicine, 2015, 13, pp.369. ⟨10.1186/s12967-015-0731-6⟩ Article dans une revue hal-02051283v1
Sequencing, annotation and analysis of the Syrian hamster (Mesocricetus auratus) transcriptome. Nicolas Tchitchek,David Safronetz,Angela L. Rasmussen,Craig Martens,Kimmo Virtanevaet al. PLoS ONE, 2014, 9 (11), pp.e112617. ⟨10.1371/journal.pone.0112617⟩ Article dans une revue hal-03961022v1
A comprehensive collection of systems biology data characterizing the host response to viral infection. Brian D. Aevermann,Brett E. Pickett,Sanjeev Kumar,Edward B. Klem,Sudhakar Agnihothramet al. Scientific Data, 2014, 1, pp.140033. ⟨10.1038/sdata.2014.33⟩ Article dans une revue hal-03961036v1
H7N9 and other pathogenic avian influenza viruses elicit a three-pronged transcriptomic signature that is reminiscent of 1918 influenza virus and is associated with lethal outcome in mice. Juliet Morrison,Laurence Josset,Nicolas Tchitchek,Jean Chang,Jessica A. Belseret al. Journal of virology, 2014, 88 (18), pp.10556--10568. ⟨10.1128/JVI.00570-14⟩ Article dans une revue hal-03961023v1
Annotation of long non-coding RNAs expressed in collaborative cross founder mice in response to respiratory virus infection reveals a new class of interferon-stimulated transcripts. Laurence Josset,Nicolas Tchitchek,Lisa E. Gralinski,Martin T. Ferris,Amie J. Eisfeldet al. RNA Biology, 2014, 11 (7), pp.875--890. ⟨10.4161/rna.29442⟩ Article dans une revue hal-03961024v1
Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice Nicolas Tchitchek,Amie Eisfeld,Jennifer Tisoncik-Go,Laurence Josset,Lisa Gralinskiet al. BMC Systems Biology, 2013, 7 (1), pp.69. ⟨10.1186/1752-0509-7-69⟩ Article dans une revue pasteur-00850969v1
Systems approaches to influenza-virus host interactions and the pathogenesis of highly virulent and pandemic viruses. Marcus J. Korth,Nicolas Tchitchek,Arndt G. Benecke,Michael G. Katze Seminars in immunology, 2013, 25 (3), pp.228--239. ⟨10.1016/j.smim.2012.11.001⟩ Article dans une revue hal-03961025v1
A Network Integration Approach to Predict Conserved Regulators Related to Pathogenicity of Influenza and SARS-CoV Respiratory Viruses Hugh D. Mitchell,Amie J. Eisfeld,Amy C. Sims,Jason E. Mcdermott,Melissa M. Matzkeet al. PLoS ONE, 2013, 8 (7), pp.e69374. ⟨10.1371/journal.pone.0069374⟩ Article dans une revue hal-01543316v1
1918 Influenza Virus Hemagglutinin (HA) and the Viral RNA Polymerase Complex Enhance Viral Pathogenicity, but Only HA Induces Aberrant Host Responses in Mice Tokiko Watanabe,Jennifer Tisoncik-Go,Nicolas Tchitchek,Shinji Watanabe,Arndt G. Beneckeet al. Journal of Virology, 2013, 87 (9), pp.5239-5254. ⟨10.1128/JVI.02753-12⟩ Article dans une revue hal-01543311v1
Expression sequence tag library derived from peripheral blood mononuclear cells of the chlorocebus sabaeus. Nicolas Tchitchek,Béatrice Jacquelin,Patrick Wincker,Carole Dossat,Corinne Da Silvaet al. BMC Genomics, 2012, 13 (1), pp.279. ⟨10.1186/1471-2164-13-279⟩ Article dans une revue inserm-00771549v1
2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models Jennifer Go,Sarah Belisle,Nicolas Tchitchek,Terrence Tumpey,Wenjun Maet al. BMC Genomics, 2012, 13 (1), pp.627. ⟨10.1186/1471-2164-13-627⟩ Article dans une revue hal-03849383v1
CDS: A Fold-change Based Statistical Test for Concomitant Identification of Distinctness and Similarity in Gene Expression Analysis Nicolas Tchitchek,José Felipe Golib Dzib,Brice Targat,Sebastian Noth,Arndt Beneckeet al. Genomics, Proteomics and Bioinformatics, 2012, 10 (3), pp.127-135. ⟨10.1016/j.gpb.2012.06.002⟩ Article dans une revue hal-01544156v1
Early transcriptional programming links progression to hepatitis C virus-induced severe liver disease in transplant patients Angela L Rasmussen,Nicolas Tchitchek,Nathan J Susnow,Alexei L Krasnoselsky,Deborah L Diamondet al. Hepatology, 2012, 56 (1), pp.17-27. ⟨10.1002/hep.25612⟩ Article dans une revue hal-01544155v1
Mineralocorticoid receptor mutations differentially affect individual gene expression profiles in pseudohypoaldosteronism type 1. Fábio L. Fernandes-Rosa,Edwige-Ludiwyne Hubert,Jérome Fagart,Nicolas Tchitchek,Debora Gomeset al. Journal of Clinical Endocrinology and Metabolism, 2011, 96 (3), pp.E519--527. ⟨10.1210/jc.2010-1486⟩ Article dans une revue hal-03961027v1
A chemokine gene expression signature derived from meta-analysis predicts the pathogenicity of viral respiratory infections Stewart Chang,Nicolas Tchitchek,Debashis Ghosh,Arndt Benecke,Michael Katze BMC Systems Biology, 2011, 5 (1), pp.202. ⟨10.1186/1752-0509-5-202⟩ Article dans une revue hal-03849356v1
Improving the efficiency of multidimensional scaling in the analysis of high-dimensional data using singular value decomposition. Christophe Bécavin,Nicolas Tchitchek,Colette Mintsa-Eya,Annick Lesne,Arndt Benecke Bioinformatics (Oxford, England), 2011, 27 (10), pp.1413--1421. ⟨10.1093/bioinformatics/btr143⟩ Article dans une revue hal-03961026v1
The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal salmonella diarrhea. Kathrin Endt,Bärbel Stecher,Samuel Chaffron,Emma Slack,Nicolas Tchitcheket al. PLoS Pathogens, 2010, 6 (9), pp.e1001097. ⟨10.1371/journal.ppat.1001097⟩ Article dans une revue inserm-00520162v1