Olivier Walker I'm Assistant Professor (Franch MCF) and the BIOSYS group leader hosted by the Institut des Sciences Analytiques. My research is currently dealing with the structural and dynamical study of biological systems by Nuclear Magnetic Resonance (NMR) and more particularly complex biomolecular assemblies.

Identifiants chercheurs

IdHAL :

olivier-walker

ORCID :

0000-0001-7284-2555

IdRef :

05992618X

ResearcherID :

B-2580-2016

Publications

Article dans une revue (41)

Molecular dynamics as an efficient process to predict 15 N chemical shift anisotropy at very high NMR magnetic fields Maggy Hologne,Po-Chia Chen,François-Xavier Cantrelle,Olivier Walker Physical Chemistry Chemical Physics, 2025, ⟨10.1039/D4CP03821E⟩ Article dans une revue hal-04882570v1
Structural and dynamical insights into SilE silver binding from combined analytical probes Yoan Monneau,Cyrielle Arrault,Coraline Duroux,Marie Martin,Fabien Chirotet al. Physical Chemistry Chemical Physics, 2023, 25 (4), pp.3061-3071. ⟨10.1039/D2CP04206A⟩ Article dans une revue hal-03960103v1
Divide, conquer and reconstruct: How to solve the 3D structure of recalcitrant Micro-Exon Gene (MEG) protein from Schistosoma mansoni Stepanka Nedvedova,Florence Guillière,Adriana Erica Miele,François-Xavier Cantrelle,Jan Dvoraket al. PLoS ONE, 2023, 18 (8), pp.e0289444. ⟨10.1371/journal.pone.0289444⟩ Article dans une revue hal-04177131v1
The battle for silver binding: How the interplay between the SilE, SilF, and SilB proteins contributes to the silver efflux pump mechanism Cyrielle Arrault,Yoan Rocky Monneau,Marie Martin,François-Xavier Cantrelle,Emmanuelle Bollet al. Journal of Biological Chemistry, 2023, 299 (8), pp.105004. ⟨10.1016/j.jbc.2023.105004⟩ Article dans une revue hal-04172931v1
Revisiting Schistosoma mansoni Micro-Exon Gene (MEG) Protein Family: A Tour into Conserved Motifs and Annotation Štěpánka Nedvědová,Davide de Stefano,Olivier Walker,Maggy Hologne,Adriana Erica Miele Biomolecules, 2023, 13 (9), pp.1275. ⟨10.3390/biom13091275⟩ Article dans une revue hal-04189192v1
NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly Tingting Niu,Charlotte de Rosny,Séverine Chautard,Amaury Rey,Danish Patoliet al. Nature Communications, 2021, 12 (1), pp.Article number: 5862. ⟨10.1038/s41467-021-26142-w⟩ Article dans une revue hal-03401509v1
NMR reveals the interplay between SilE and SilB model peptides in the context of silver resistance Lucille Babel,Minh-Ha Nguyen,Cédric Mittelheisser,Marie Martin,Katharina Frommet al. Chemical Communications, 2021, 57, pp.8726-8729. ⟨10.1039/d1cc02597j⟩ Article dans une revue hal-03324047v1
Accurate Prediction of Protein NMR Spin Relaxation by Means of Polarizable Force Fields. Application to Strongly Anisotropic Rotational Diffusion Moreno Marcellini,Minh-Ha Nguyen,Marie Martin,Maggy Hologne,Olivier Walker Journal of Physical Chemistry B, 2020, 124 (25), pp.5103-5112. ⟨10.1021/acs.jpcb.0c01922⟩ Article dans une revue hal-03968000v1
Regulation of measles virus gene expression by P protein coiled-coil properties Louis-Marie Bloyet,Antoine Schramm,Carine Lazert,Bertrand Raynal,Maggy Hologneet al. Science Advances , 2019, 5 (5), pp.eaaw3702. ⟨10.1126/sciadv.aaw3702⟩ Article dans une revue hal-02133726v1
Molecular recognition of ubiquitin and Lys63-linked diubiquitin by STAM2 UIM-SH3 dual domain: the effect of its linker length and flexibility Minh-Ha Nguyen,Marie Martin,Henry Kim,Frank Gabel,Olivier Walkeret al. Scientific Reports, 2019, 9 (1), pp.14645. ⟨10.1038/s41598-019-51182-0⟩ Article dans une revue hal-03968013v1
Ab Initio Prediction of NMR Spin Relaxation Parameters from Molecular Dynamics Simulations Po-Chia Chen,Maggy Hologne,Olivier Walker,Janosch Hennig Journal of Chemical Theory and Computation, 2018, 14 (2), pp.1009 - 1019. ⟨10.1021/acs.jctc.7b00750⟩ Article dans une revue hal-01767727v1
Alpha-helical folding of SilE models upon Ag(His)(Met) motif formation Valentin Chabert,Maggy Hologne,Olivier Sénèque,Olivier Walker,Katharina Fromm Chemical Communications, 2018, 54 (74), pp.10419 - 10422. ⟨10.1039/c8cc03784a⟩ Article dans une revue hal-01900232v1
Computing the rotational diffusion of biomolecules via molecular dynamics simulation and quaternion orientations Po-Chia Chen,Maggy Hologne,Olivier Walker Journal of Physical Chemistry B, 2017, 121 (8), pp.1812-1823. ⟨10.1021/acs.jpcb.6b11703⟩ Article dans une revue hal-01520066v1
Model peptide studies of Ag + binding sites from the silver resistance protein SilE V. Chabert,Maggy Hologne,O. Sénéque,A. Crochet,Olivier Walkeret al. Chemical Communications, 2017, 53 (45), pp.6105 - 6108. ⟨10.1039/c7cc02630g⟩ Article dans une revue hal-01546472v1
Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway Mark Nakasone,Timothy A. Lewis,Olivier Walker,Anita Thakur,Wissam Mansouret al. Structure, 2017, 25 (12), pp.1839 - 1855.e11. ⟨10.1016/j.str.2017.10.007⟩ Article dans une revue hal-01679528v1
Francisella tularensis IglG Belongs to a Novel Family of PAAR-Like T6SS Proteins and Harbors a Unique N-terminal Extension Required for Virulence Mélanie Rigard,Jeanette E. Bröms,Amandine Mosnier,Maggy Hologne,Amandine Martinet al. PLoS Pathogens, 2016, 12 (9), pp.article number: e1005821. ⟨10.1371/journal.ppat.1005821⟩ Article dans une revue hal-01546486v1
Linkage via K27 bestows ubiquitin chains with unique properties among polyubiquitins Carlos A Castaneda,Emma K Dixon,Olivier Walker,Apurva Chaturvedi,Mark A Nakasoneet al. Structure, 2016, 24 (3), pp.423-436. ⟨10.1016/j.str.2016.01.007⟩ Article dans une revue hal-01359763v1
NMR Reveals the Interplay among the AMSH SH3 Binding Motif, STAM2, and Lys63-Linked Diubiquitin. Maggy Hologne,Xavier Cantrelle,Gwladys Riviere,Florence Guillière,Xavier Trivelliet al. Journal of Molecular Biology, 2016, 428 (22), pp.4544-4558. ⟨10.1016/j.jmb.2016.10.002⟩ Article dans une revue hal-01546483v1
Funnel-metadynamics and solution NMR to estimate protein-ligand affinities Laura Troussicot,Florence Guillière,Vittorio Limongelli,Olivier Walker,Jean-Marc Lancelin Journal of the American Chemical Society, 2015, 137 (3), pp.1273-1281. ⟨10.1021/ja511336z⟩ Article dans une revue hal-01187402v1
DNA-damage-inducible 1 protein (Ddi1) contains an uncharacteristic ubiquitin-like domain that binds ubiquitin Urszula Nowicka,Daoning Zhang,Olivier Walker,Daria Krutauz,Carlos A Castanedaet al. Structure, 2015, 23 (3), pp.542-557. ⟨10.1016/j.str.2015.01.010⟩ Article dans une revue hal-01187309v1
Versatile Roles of K63-Linked Ubiquitin Chains in Trafficking Zoi Erpapazoglou,Olivier Walker,Rosine Haguenauer-Tsapis STEM CELLS, 2014, 3 (4), pp.1027-1088. ⟨10.3390/cells3041027⟩ Article dans une revue hal-01128389v1
BcL-xL Conformational Changes upon Fragment Binding Revealed by NMR Clémentine Aguirre,Tim Ten Brink,Olivier Walker,Florence Guillière,D. Davesneet al. PLoS ONE, 2013, 8, pp.e64400. ⟨10.1371/journal.pone.0064400⟩ Article dans une revue in2p3-00839023v1
Evidence for cooperative and domain-specific binding of the signal transducing adaptor molecule 2 (STAM2) to lys(63)-linked diubiquitin Anja Lange,Carlos Castaneda,Daniela Hoeller,Jean-Marc Lancelin,David Fushmanet al. Journal of Biological Chemistry, 2012, 287 (22), pp.18687-18699. ⟨10.1074/jbc.M111.324954⟩ Article dans une revue hal-00873866v1
Competitive binding of UBPY and ubiquitin to the STAM2 SH3 domain revealed by NMR Anja Lange,Mouhamad-Baligh Ismail,Gwladys Rivière,Maggy Hologne,Denis Lacabanneet al. FEBS Letters, 2012, 586 (19), pp.3379-3384. ⟨10.1016/j.febslet.2012.07.047⟩ Article dans une revue istex hal-00819142v1
NMR Reveals a Different Mode of Binding of the Stam2 VHS Domain to Ubiquitin and Diubiquitin Anja Lange,Daniela Hoeller,Hans Wienk,Olivier Marcillat,Jean-Marc Lancelinet al. Biochemistry, 2011, 50 (1), pp.48-62. ⟨10.1021/bi101594a⟩ Article dans une revue hal-00873854v1
Exploring the Linkage Dependence of Polyubiquitin Conformations Using Molecular Modeling David Fushman,Olivier Walker Journal of Molecular Biology, 2010, 395 (4), pp.803-814. ⟨10.1016/j.jmb.2009.10.039⟩ Article dans une revue hal-04887933v1
NMR Screening Applied to the Fragment-based Generation of Inhibitors of Creatine Kinase exploiting a new interaction proximate to the ATP binding site. A.-S. Bretonnet,A. Jochum,Olivier Walker,Isabelle Krimm,Peter Goekjianet al. Journal of Medicinal Chemistry, 2007, pp.1865-1875 Article dans une revue hal-00445422v1
Protein–protein interactions within peroxiredoxin systems Valérie Noguera-Mazon,Isabelle Krimm,Olivier Walker,Jean-Marc Lancelin Photosynthesis Research, 2006, 89 (2-3), pp.277-290. ⟨10.1007/s11120-006-9106-4⟩ Article dans une revue istex hal-04887927v1
Glutathionylation induces the dissociation of 1-Cys D-peroxiredoxin non-covalent homodimer Valérie Noguera-Mazon,Jérôme Lemoine,Olivier Walker,Nicolas Rouhier,Arnaud Salvadoret al. Journal of Biological Chemistry, 2006, 381 (42), pp.31736-31742. ⟨10.1074/jbc.M602188200⟩ Article dans une revue hal-02661917v1
NMR reveals a novel glutaredoxin-glutaredoxin interaction interface V. Noguera,O. Walker,Nicolas Rouhier,J.P. Jacquot,I. Krimmet al. Journal of Molecular Biology, 2005, 353 (3), pp.629-641. ⟨10.1016/j.jmb.2005.08.035⟩ Article dans une revue istex hal-02679450v1
Crystal Structure and Solution NMR Dynamics of a D (Type II) Peroxiredoxin Glutaredoxin and Thioredoxin Dependent: A New Insight into the Peroxiredoxin Oligomerism Aude Echalier,Xavier Trivelli,Catherine Corbier,Nicolas Rouhier,Olivier Walkeret al. Biochemistry, 2005, 44 (6), pp.1755-1767. ⟨10.1021/bi048226s⟩ Article dans une revue istex hal-02680941v1
Characterization of the Overall Rotational Diffusion of a Protein From &lt;sup&gt;15&lt;/sup&gt;N Relaxation Measurements and Hydrodynamic Calculations Jennifer Blake-Hall,Oliver Walker,David Fushman Methods in Molecular Biology, 2004, 278, pp.139-160. ⟨10.1385/1-59259-809-9:139⟩ Article dans une revue hal-04887900v1
Efficient and accurate determination of the overall rotational diffusion tensor of a molecule from 15N relaxation data using computer program ROTDIF Olivier Walker,Ranjani Varadan,David Fushman Journal of Magnetic Resonance, 2004, 168 (2), pp.336-345. ⟨10.1016/j.jmr.2004.03.019⟩ Article dans une revue istex hal-04887347v1
Determining domain orientation in macromolecules by using spin-relaxation and residual dipolar coupling measurements David Fushman,Ranjani Varadan,Michael Assfalg,Olivier Walker Progress in Nuclear Magnetic Resonance Spectroscopy, 2004, 44 (3-4), pp.189-214. ⟨10.1016/j.pnmrs.2004.02.001⟩ Article dans une revue istex hal-04887351v1
Heteronuclear Overhauser experiments for symmetric molecules O. Walker,P. Mutzenhardt,D. Canet Magnetic Resonance in Chemistry, 2003, 41 (10), pp.776-781. ⟨10.1002/mrc.1255⟩ Article dans une revue istex hal-04887344v1
Structural Properties of Polyubiquitin Chains in Solution Ranjani Varadan,Olivier Walker,Cecile Pickart,David Fushman Journal of Molecular Biology, 2002, 324 (4), pp.637-647. ⟨10.1016/s0022-2836(02)01198-1⟩ Article dans une revue istex hal-04886970v1
Determination of Carbon-13 Chemical Shielding Tensor in the Liquid State by Combining NMR Relaxation Experiments and Quantum Chemical Calculations O. Walker,P. Mutzenhardt,P. Tekely,D. Canet Journal of the American Chemical Society, 2002, 124 (5), pp.865-873. ⟨10.1021/ja0166702⟩ Article dans une revue istex hal-04887321v1
Solvent dependence of rotational anisotropy and molecular geometry as probed by NMR cross-relaxation rates O. Walker,P. Mutzenhardt,J.P. Joly,D. Canet Chemical Physics Letters, 2002, 357 (1-2), pp.103-107. ⟨10.1016/s0009-2614(02)00449-9⟩ Article dans une revue istex hal-04887293v1
Determination of the rotation-diffusion tensor orientation from NMR 13C-1H cross-relaxation rates O. Walker,P. Mutzenhardt,E. Haloui,J.-C. Boubel,D. Canet Molecular Physics, 2002, 100 (17), pp.2755-2761. ⟨10.1080/00268970210141199⟩ Article dans une revue hal-04887317v1
Synthesis and spectral study of (2&lt;i&gt;R&lt;/i&gt;,11&lt;i&gt;R&lt;/i&gt;)‐2,11‐bis{[(2‐methoxyethoxy)methoxy]methyl}‐1,10‐dibenzyl‐4,7,13,16‐tetraoxa‐1,10‐diaza‐cyclooctadecane Jean-Pierre Joly,Olivier Walker,Pierre Mutzenhardt Magnetic Resonance in Chemistry, 2001, 39, pp.212 - 214. ⟨10.1002/mrc.818⟩ Article dans une revue hal-04886960v1
Anisotropy of molecular reorientation and geometrical information as determined from short and long range 13C-1H spin cross-relaxation rates Pierre Mutzenhardt,O. Walker,Daniel Canet,E. Haloui,Istvan Furo Molecular Physics, 1998, 94 (3), pp.565. ⟨10.1080/002689798168079⟩ Article dans une revue hal-04891261v1

Communication dans un congrès (15)

Unveiling the Enigma: Structural Insights into Schistosoma mansoni MEG Proteins Stepanka Nedvedova,Florence Guillière,Adriana E. Miele,François-Xavier Cantrelle,Davide de Stefanoet al. AILM 2024, May 2024, Grenoble, France Communication dans un congrès hal-04967921v1
THE BATTLE FOR SILVER BINDING: HOW THE INTERPLAY BETWEEN THE SILE, SILF AND SILB PROTEINS CONTRIBUTES TO THE SILVER EFFLUX PUMP Maggy Hologne,Cyrielle Arrault,Yoan Monneau,Marie Martin,François-Xavier Cantrelleet al. 4èmes Journées RMN du Grand Sud, May 2023, Lyon, France Communication dans un congrès hal-04708097v1
Combining NMR and molecular dynamics to explore protein motions Moreno Marcellini,Minh-Ha Nguyen,Marie Martin,Maggy Hologne,Olivier Walker Fifth Biological Diffusion and Brownian Dynamics Brainstorm Meeting, Heidelberger Institut für Theoretische Studien, Mar 2021, Heidelberg (virtual), Germany Communication dans un congrès hal-03199977v1
Combining a polarizable force field and experimental data to improve the prediction of NMR spin relaxation parameters Moreno Marcellini,Minh-Ha Nguyen,Marie Martin,Maggy Hologne,Olivier Walker 61st Experimental Nuclear Magnetic Resonance Conference - 61st ENC, Mar 2020, Baltimore, United States Communication dans un congrès hal-02472153v1
NMR studies revealed structural basis for the inhibitory effects of ubistatins in the ubiquitin-mediated signaling pathways Mark Nakasone,Thimothy Lewis,Olivier Walker,Jennifer L. Goeckeler-Fried,Daoning Zhanget al. XXVIII International Conference on Magnetic Resonance in Biological Systems (ICMRBS), University College Dublin, Aug 2018, Dublin, Ireland Communication dans un congrès hal-01862632v1
Combining NMR, SANS and molecular dynamics in the context of biomolecular interactions. Application to proteasomal and lysosomal degradation Maggy Hologne,Francois-Xavier Cantrelle,Xavier Trivelli,Olivier Walker LyonSysBio 2016, Systems Biology Alliance of Lyon - BioSyL, Nov 2016, Lyon, France Communication dans un congrès hal-02134880v1
Using NMR and molecular dynamics as a microscope for life science. Application to the determination of protein-ligand affinity Jean-Marc Lancelin,Florence Guillière,Maggy Hologne,Olivier Walker Rhône-Alpes meeting - Drug screening: From phenotypes to molecular modeling, Feb 2014, Lyon, France Communication dans un congrès hal-00958236v1
Exploring Protein/protein and protein/ligand interactions: What can NMR do for you? Olivier Walker séminaire du CRM2 (UMR 7036 CNRS Université de Nancy 1), Mar 2013, Vandoeuvre-lès-Nancy, France Communication dans un congrès hal-00958253v1
MD exploration of human peroxiredoxin V interactions with ligands Jean-Marc Lancelin,Florence Guillière,V. Limongeli,Olivier Walker High-throughput molecular dynamics workshop, Nov 2013, Barcelone, Spain Communication dans un congrès hal-00958248v1
Molecular dynamics as a tool to understand binding hot spots. Application to the binding of STAM2-SH3 with UBPY and ubiquitin Jean-Marc Lancelin,Florence Guillière,L. Limongeli,Olivier Walker 1st French-Italian joint meeting on subcellular trafficking, Nov 2013, Barcelone, Spain Communication dans un congrès hal-00958321v1
NMR identifies SH3 as a new Ubiquitin Binding Domain of the Signal Transducing Adaptor Molecule 2 (STAM2) M.-B. Ismail,Florence Guillière,Jean-Marc Lancelin,Isabelle Krimm,Olivier Walker XXVth International Conference on Magnetic Resonance in Biological Systems (ICMRBS), Aug 2012, Lyon, France Communication dans un congrès hal-00958283v1
Tackling the Interaction of the Multidomain Protein STAM2 with Ubiquitin and Diubiquitin Chains by NMR. Cooperativity or not, that is the Question ! Florence Guillière,Jean-Marc Lancelin,Isabelle Krimm,Olivier Walker,Anja Lange XXVth International Conference on Magnetic Resonance in Biological Systems (ICMRBS), Aug 2012, Lyon, France Communication dans un congrès hal-00958296v1
Tackling the Interaction of the Multidomain Protein STAM2 with Ubiquitin and Polyubiquitin Chains by NMR. Cooperativity or not, that is the Question ! Anja Lange,Carlos Castaneda,D. Hoeller,H. Wienk,Jean-Marc Lancelinet al. XIIIe Journée Rhône-Alpes de RMN (JRA 2012), Jun 2012, Grenoble, France Communication dans un congrès hal-00958256v1
Tackling the interaction of STAM2 with ubiquitin and polyubiquitin chains by structural and dynamical NMR. Cooperativity or not, that is the question ! Anja Lange,Carlos Castaneda,Daniela Hoeller,Hans Wienk,Jean-Marc Lancelinet al. 1st French-Italian joint meeting on subcellular trafficking, May 2011, Padoue, Italy Communication dans un congrès hal-00958272v1
Evidence for cooperative and specific binding of STAM2 with K63-linked diubiquitin Anja Lange,Carlos Castaneda,Daniela Hoeller,Jean-Marc Lancelin,David Fushmanet al. Lecture, Department of chemistry and biochemistry at University of Maryland, Aug 2011, Maryland, United States Communication dans un congrès hal-00958263v1

Poster de conférence (10)

The interplay between the SilF and SilB proteins contributes to the silver efflux pump mechanism Cyrielle Arrault,Yoan Monneau,Marie Martin,François-Xavier Cantrelle,Emmanuelle Bollet al. 4èmes Journées RMN du Grand Sud, May 2023, Lyon, France Poster de conférence hal-04708177v1
The interplay between the SilF and SilB proteins contributes to the silver efflux pump mechanism Cyrielle Arrault,Yoan Monneau,Marie Martin,François-Xavier Cantrelle,Emmanuelle Bollet al. 2nd MOSBRI Scientific Conference, Jun 2023, Zaragoza, Spain Poster de conférence hal-04708161v1
A better understanding of the interplay between SilF and SilB proteins in the resistance mechanism of the silver efflux pump Cyrielle Arrault,Yoan Monneau,Marie Martin,François-Xavier Cantrelle,Emmanuelle Bollet al. GLP Arbre Symposium, Jun 2023, Lyon, France Poster de conférence hal-04708147v1
Ag influence on SilE, an intrinsically disordered protein C. Comby-Zerbino,Marie Martin,Caroline Duroux,Marion Girod,Yoan Rocky Monneauet al. IMSC 2022, Aug 2022, Maastricht, Netherlands Poster de conférence hal-04968010v1
Modéliser la dynamique des proteins multi-domaines et leurs interactions en combinant modélisation et approches expérimentales Maggy Hologne,Olivier Walker,Marie Martin Journée de restitution MITI Modélisation du vivant, Feb 2022, Paris (en ligne), France Poster de conférence hal-04007020v1
Comprendre la résistance à l’argent de certaines bactéries. Et si la protéine SilE était responsable ? Maggy Hologne,Olivier Walker,Marie Martin Journée de restitution MITI Metallo-mix, Jan 2022, Paris (en ligne), France Poster de conférence hal-04005990v1
Interplay between SilB and SilE derived peptides : a silver story ! Maggy Hologne,Olivier Walker,Marie Martin 62nd ENC, Mar 2021, Virtual conference, France Poster de conférence hal-04006004v1
Ab-initio prediction of NMR spin-relaxation parameters from MD simulations Olivier Walker,Maggy Hologne,Po-Chia Chen 64th Annual Meeting of the Biophysical Society, Feb 2020, San Diego (CA), United States Poster de conférence hal-04006023v1
Dependence of the linker length and stiffness on the molecular recognition of UIM-SH3 with Ub and Ub2-K63 Minh-Ha Nguyen,Marie Martin,Henry Kim,Frank Gabel,Olivier Walkeret al. EUROISMAR 2019, Aug 2019, Berlin, Germany Poster de conférence hal-04708196v1
Investigation of the flexibility of multi-domain protein. An application on a protein complex of the lysosomal degradation pathway Minh-Ha Nguyen,Maggy Hologne,Marie Martin,Olivier Walker XXVIIIth ICMRBS, Aug 2018, Dublin, Ireland Poster de conférence hal-04708214v1

Pré-publication, Document de travail (1)

Mechanism of Ag+-induced Folding of a Bacterial Peptide from Replica-Exchange Molecular Simulations Florian E.C. Blanc,Maggy Hologne,Marion Girod,Mélodie Demontrond,Henry Chermetteet al. 2026 Pré-publication, Document de travail hal-05492425v1

Thèse (1)

Développements méthodologiques destinés à la détermination des propriétés moléculaires à partir de mesures de relaxation hétéronucléaire Olivier Walker Autre. Université Henri Poincaré - Nancy 1, 2001. Français. ⟨NNT : 2001NAN10187⟩ Thèse tel-01746863v1

HDR (1)

Habilitation à diriger des recherches Olivier Walker Theoretical and/or physical chemistry. Lyon 1, 2008 HDR tel-04883049v1