Ovidiu Radulescu

116
Documents

Présentation

**EDUCATION

Habilitation in Applied Mathematics (University of Rennes 1, 11/12/2006)

Master degree in Probability theory and analysis (University of Marne-la-Vallée, 1996)

PhD in Theoretical Solid State Physics (Orsay, University of Paris 11, 1994)

Engineering degree in Solid State Physics (University of Bucharest, 1989)

PROFESSIONAL CAREER

Current position : Full Professor (Professeur classe exceptionnelle), Team leader in the Laboratory of Pathogen Host Interactions (LPHI) UMR 5235, University of Montpellier, since 2009.

Other positions

01/09/1999-31/08/2009, Institute for Mathematical Research (IRMAR), University of Rennes 1, Rennes, France, Associate Professor in mathematics (MCF classe normale, CNU26)

01/09/2005-31/08/2007, National Institute for Computer Science and Applied Mathematics (INRIA), team SYMBIOSE, Rennes, France, Visiting professor (secondment, délégation).

01/03/1998-31/08/2009, IRC in Polymer Physics and Department of Physics, University of Leeds, Leeds, UK, Post-doc in theoretical polymer physics.

01/03/1996-28/02/1998 Institute of Theoretical Physics, Raadboud University, Nijmegen, The Netherlands, HCM EU fellow in theoretical condensed matter physics.

01/09/1993-28/02/1996, University of Marne-la-Vallée, Noisy le Grand, France, Assistant Professor (untenured teaching and research position, ATER) in theoretical condensed matter physics.

01/09/1990-31/08/1993, University of Paris 11, Orsay, France, Teaching assistant (Moniteur).

01/01/1990-31/08/1990, Institute of Research on Materials, Bucharest, Romania, Researcher in theoretical condensed matter theory.

Recent Management Activities:

Member of the Councils of University of Rennes 1 (2008-2009) and University of Montpellier (2011-2015); Adjoint chief of the BioHealth Department at University of Montpellier (2013-2014)

Participation to National and International Scientific Networks Management

Coordinator of the Interdisciplinary axis of Pole Rabelais; Member of Labex Epigenmed; Member of the international network IPols (International Physics of Living Systems Program).

Participation to National and International Expert Committees

Expert for ERC (European Research Council), ANR (French National Research Agency), HCERES (High Council for the Evaluation of Research and Higher Education), NW0 (Netherlands Organisation for Scientific Research)

Member of the interdisciplinary committee CID51 of CNRS (2013-2016).

Editorial activity:

Associated Editor of Frontiers in Bioinformatics and Computational Biology.

Participation to program committees (PC) of international conferences:

Member of the PC of the International Workshop on Static Analysis and Systems Biology SASB (2011-12)

Member of the PC of the International Conference on Computational Methods in Systems Biology CMSB (2011-12, 2015-20)

Member of the PC of the Workshop on Interactions between Computer Science and Biology CS2BIO (2014)

Member of the PC of the IEEE International Conference on Computational Intelligence in Bioinformatics and Computational Biology CIBCB (2019-20)

Supervision:

Supervision of 10 phD students, 31 master students, 5 post-docs

Direction of the master program “Biophysics Structure and Systems”

Recent invited international conferences:

1) Keynote talk, CASC 2020 (Computer Algebra in Scientific Computing), Linz, Austria, Sept 14-18, 2020.

2) Plenary invited talk, Workshop on Robustness, Heterogeneity and Adaptation, Gordon Center for Integrative Sciences, University of Chicago, June 20-21, 2016.

3) Plenary invited talk, Symmetry and Dynamics in Biology, Paulista Medical School, (EPM – Unifesp), São Paulo -SP-Brazil, April 17, 2015.

4) Plenary invited talk, workshop Mathematical Trends in Reaction Network Theory, Copenhagen, July 1-3, 2015.

5) Plenary invited talk, Applications of statistical physics in quantitative biology mini-symposium, 9th European Conference on Mathematical and Theoretical Biology, Gothenburg, Sweden, 2014.

6) Invited talk, Franco-Indian Technology Summit, IT & Health, 24 Octobre 2013, New Delhi, India.

7) Keynote talk, 9th BioMalPar - Evimalar Conference, 13-15 Octobre 2013, EMBL Heidelberg, Germany.

HONORSANDAWARDS

Medals at International Physics Olympiads (1981 bronze, 1982 silver); BGF (French government) fellow (1990-94); DAAD fellow (1995); HCM EU fellow (1996-98); bonus for scientific excellence (PES, PEDR) since 2009.

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Publications

A Computational Approach to Polynomial Conservation Laws

Aurélien Desoeuvres , Alexandru Iosif , Christoph Lüders , Ovidiu Radulescu , Hamid Rahkooy et al.
SIAM Journal on Applied Dynamical Systems, 2024, 23 (1), pp.813-854. ⟨10.1137/22M1544014⟩
Article dans une revue hal-04795722 v1

Reduction of Chemical Reaction Networks with Approximate Conservation Laws

Aurélien Desoeuvres , Alexandru Iosif , Christoph Lüders , Ovidiu Radulescu , Hamid Rahkooy et al.
SIAM Journal on Applied Dynamical Systems, 2024, 23 (1), pp.256-296. ⟨10.1137/22M1543963⟩
Article dans une revue hal-04797423 v1

Identifying Markov Chain Models from Time-to-Event Data: An Algebraic Approach

Ovidiu Radulescu , Dima Grigoriev , Matthias Seiss , Maria Douaihy , Mounia Lagha et al.
Bulletin of Mathematical Biology, 2024, 87 (1), pp.11. ⟨10.1007/s11538-024-01385-y⟩
Article dans une revue hal-04958556 v1
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Deciphering oxygen distribution and hypoxia profiles in the tumor microenvironment: a data-driven mechanistic modeling approach

Pawan Kumar , Matthieu Lacroix , Pierrick Dupré , Janan Arslan , Lise Fenou et al.
Physics in Medicine and Biology, 2024, 69 (12), pp.125023. ⟨10.1088/1361-6560/ad524a⟩
Article dans une revue hal-04612770 v1
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BurstDECONV: a signal deconvolution method to uncover mechanisms of transcriptional bursting in live cells

Maria Douaihy , Rachel Topno , Mounia Lagha , Edouard Bertrand , Ovidiu Radulescu
Nucleic Acids Research, 2023, 51 (16), pp.e88-e88. ⟨10.1093/nar/gkad629⟩
Article dans une revue hal-04286170 v1
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A Skin Microbiome Model with AMP interactions and Analysis of Quasi-Stability vs Stability in Population Dynamics

Eléa Thibault Greugny , François Fages , Ovidiu Radulescu , Peter Szmolyan , Georgios Stamatas
Theoretical Computer Science, 2023, pp.114294. ⟨10.1016/j.tcs.2023.114294⟩
Article dans une revue hal-04253028 v1
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Transcriptional Stochasticity as a Key Aspect of HIV-1 Latency

Alexia Damour , Vera Slaninova , Ovidiu Radulescu , Edouard Bertrand , Eugenia Basyuk
Viruses, 2023, 15 (9), pp.1969. ⟨10.3390/v15091969⟩
Article dans une revue hal-04235056 v1
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La résistance aux inhibiteurs de BRAF, les leçons de la clinique

Cylia Dahmani , Eulalie Corre , Sarah Dandou , Alain Mangé , Ovidiu Radulescu et al.
Médecine/Sciences, 2022, 38 (6-7), pp.570-578. ⟨10.1051/medsci/2022083⟩
Article dans une revue hal-03805000 v1

ODEbase: A Repository of ODE Systems for Systems Biology

Christoph Lüders , Thomas Sturm , Ovidiu Radulescu
Bioinformatics Advances, 2022, 2 (1), ⟨10.1093/bioadv/vbac027⟩
Article dans une revue hal-03651751 v1
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Computational Model of Heterogeneity in Melanoma: Designing Therapies and Predicting Outcomes

Arran Hodgkinson , Dumitru Trucu , Matthieu Lacroix , Laurent Le Cam , Ovidiu Radulescu
Frontiers in Oncology, 2022, 12, pp.857572. ⟨10.3389/fonc.2022.857572⟩
Article dans une revue hal-03644347 v1
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The control of transcriptional memory by stable mitotic bookmarking

Maëlle Bellec , Jérémy Dufourt , George Hunt , Hélène Lenden-Hasse , Antonio Trullo et al.
Nature Communications, 2022, 13 (1), pp.1176. ⟨10.1038/s41467-022-28855-y⟩
Article dans une revue hal-03858303 v1
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Push-forward method for piecewise deterministic biochemical simulations

Guilherme C.P. Innocentini , Arran Hodgkinson , Fernando Antoneli , Arnaud Debussche , Ovidiu Radulescu
Theoretical Computer Science, 2021, 893, pp.17-40. ⟨10.1016/j.tcs.2021.05.025⟩
Article dans une revue hal-03644175 v1
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Comparison of SYK Signaling Networks Reveals the Potential Molecular Determinants of Its Tumor-Promoting and Suppressing Functions

Marion Buffard , Aurélien Naldi , Gilles Gf Freiss , Marcel Deckert , Ovidiu Radulescu et al.
Biomolecules, 2021, 11 (2), pp.308. ⟨10.3390/biom11020308⟩
Article dans une revue hal-03160560 v1
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Stochastic pausing at latent HIV-1 promoters generates transcriptional bursting

Katjana Tantale , Encar Garcia-Oliver , Marie-Cécile Robert , Adèle L’hostis , Yueyuxiao Yang et al.
Nature Communications, 2021, 12 (1), pp.4503. ⟨10.1038/s41467-021-24462-5⟩
Article dans une revue hal-03382893 v1
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Push-forward method for piecewise deterministic biochemical simulations

Guilherme C. P. Innocentini , Arran Hodgkinson , Fernando Antoneli , Arnaud Debussche , Ovidiu Radulescu
Theoretical Computer Science, 2021, 893, pp.17-40. ⟨10.1016/j.tcs.2021.05.025⟩
Article dans une revue hal-03137189 v1
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Algorithmic Reduction of Biological Networks with Multiple Time Scales

Niclas Kruff , Christoph Lüders , Ovidiu Radulescu , Thomas Sturm , Sebastian Walcher
Mathematics in Computer Science, 2021, 15 (3), pp.499 - 534. ⟨10.1007/s11786-021-00515-2⟩
Article dans une revue hal-03438176 v1
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Quantitative imaging of transcription in living Drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics

Virginia L Pimmett , Matthieu Dejean , Carola Fernandez , Antonio Trullo , Edouard Bertrand et al.
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-021-24461-6⟩
Article dans une revue hal-03382887 v1
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Identifying the parametric occurrence of multiple steady states for some biological networks

Russell Bradford , James Harold Davenport , Matthew England , Hassan Errami , Vladimir Gerdt et al.
Journal of Symbolic Computation, 2020, 98, pp.84-119. ⟨10.1016/j.jsc.2019.07.008⟩
Article dans une revue hal-02397154 v1
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An in silico analysis of robust but fragile gene regulation links enhancer length to robustness

Kenneth Barr , John Reinitz , Ovidiu Radulescu
PLoS Computational Biology, 2019, 15 (11), pp.e1007497. ⟨10.1371/journal.pcbi.1007497⟩
Article dans une revue hal-03644267 v1
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Spatio-Genetic and phenotypic modelling elucidates resistance and re-sensitisation to treatment in heterogeneous melanoma

Arran Hodgkinson , Laurent Le Cam , Dumitru Trucu , Ovidiu Radulescu
Journal of Theoretical Biology, 2019, 466, pp.84 - 105. ⟨10.1016/j.jtbi.2018.11.037⟩
Article dans une revue hal-03486027 v1
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Zelda, le maestro du réveil du génome zygotique

Jeremy Dufourt , Maëlle Bellec , Olivier Messina , Antonio Trullo , Cyril Favard et al.
Médecine/Sciences, 2019, 35 (11), pp.821-841. ⟨10.1051/medsci/2019160⟩
Article dans une revue hal-03644266 v1
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Is biological randomness a statistical physics concept?

Ovidiu Radulescu , Adrian Devenyi
LINKs series, 2019, pp.120-123
Article dans une revue hal-02532029 v1
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Network Reconstruction and Significant Pathway Extraction Using Phosphoproteomic Data from Cancer Cells

Marion Buffard , Aurélien Naldi , Ovidiu Radulescu , Peter Coopman , Romain Larive et al.
Proteomics, 2019, 19 (21-22), pp.1800450. ⟨10.1002/pmic.201800450⟩
Article dans une revue hal-03049205 v1
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Cyclin A-cdk1-Dependent Phosphorylation of Bora Is the Triggering Factor Promoting Mitotic Entry

Suzanne Vigneron , Lena Sundermann , Jean-Claude Labbé , Lionel Pintard , Ovidiu Radulescu et al.
Developmental Cell, 2018, 45 (5), pp.637--650.e7. ⟨10.1016/j.devcel.2018.05.005⟩
Article dans une revue hal-01872979 v1
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Signal Propagation in Sensing and Reciprocating Cellular Systems with Spatial and Structural Heterogeneity

Arran Hodgkinson , Ovidiu Radulescu , · Gilles Uzé , Dumitru Trucu
Bulletin of Mathematical Biology, 2018, 80 (7), pp.1900-1936. ⟨10.1007/s11538-018-0439-x⟩
Article dans une revue hal-02322020 v1

The SYMBIONT project: symbolic methods for biological networks

François Boulier , François Fages , Ovidiu Radulescu , Satya Swarup Samal , Andreas Schuppert et al.
ACM Communications in Computer Algebra, 2018, 52 (3), pp.67-70. ⟨10.1145/3313880.3313885⟩
Article dans une revue hal-02061018 v1
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Remembering the past: Mitotic bookmarking in a developing embryo

Maëlle Bellec , Ovidiu Radulescu , Mounia Lagha
Current Opinion in Systems Biology, 2018, 11, pp.41-49. ⟨10.1016/j.coisb.2018.08.003⟩
Article dans une revue hal-02323370 v1
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Time Dependent Stochastic mRNA and Protein Synthesis in Piecewise-Deterministic Models of Gene Networks

Guilherme Innocentini , Arran Hodgkinson , Ovidiu Radulescu
Frontiers in Physics, 2018, 6, pp.46. ⟨10.3389/fphy.2018.00046⟩
Article dans une revue hal-03644316 v1
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Temporal control of gene expression by the pioneer factor Zelda through transient interactions in hubs

Jeremy Dufourt , Antonio Trullo , Jennifer Hunter , Carola Fernandez , Jorge Lazaro et al.
Nature Communications, 2018, 9 (1), pp.821 - 841. ⟨10.1038/s41467-018-07613-z⟩
Article dans une revue hal-02323402 v1

Transcriptional Memory in the Drosophila Embryo

Mounia Lagha , Teresa Ferraro , Jeremy Dufourt , Ovidiu Radulescu , Matilde Mantovani
Mechanisms of Development, 2017, 145, pp.S137. ⟨10.1016/j.mod.2017.04.382⟩
Article dans une revue hal-03644293 v1
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Reconstruction and signal propagation analysis of the Syk signaling network in breast cancer cells

Aurélien Naldi , Romain Larive , Urszula Czerwinska , Serge Urbach , Philippe Montcourrier et al.
PLoS Computational Biology, 2017, 13 (3), pp.e1005432. ⟨10.1371/journal.pcbi.1005432⟩
Article dans une revue hal-02073659 v1
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Far-From-Equilibrium Time Evolution between Two Gamma Distributions

Eun-Jin Kim , Lucille-Marie Tenkès , Rainer Hollerbach , Ovidiu Radulescu
Entropy, 2017, 19 (10), pp.511. ⟨10.3390/e19100511⟩
Article dans une revue hal-03644310 v1

Linking metabolic network features to phenotypes using sparse group lasso

Satya Swarup Samal , Ovidiu Radulescu , Andreas Weber , Holger Fröhlich
Bioinformatics, 2017, 33 (21), pp.3445-3453. ⟨10.1093/bioinformatics/btx427⟩
Article dans une revue hal-03644287 v1
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Centralized Networks to Generate Human Body Motions

Sergei Vakulenko , Ovidiu Radulescu , Ivan Morozov , Andres Weber
Sensors, 2017, 17 (12), pp.2907. ⟨10.3390/s17122907⟩
Article dans une revue hal-03644285 v1

Protein Synthesis Driven by Dynamical Stochastic Transcription

Guilherme Innocentini , Michael Forger , Ovidiu Radulescu , Fernando Antoneli
Bulletin of Mathematical Biology, 2016, 78 (1), pp.110-131. ⟨10.1007/s11538-015-0131-3⟩
Article dans une revue hal-03644309 v1
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Geometric analysis of pathways dynamics: application to versatility of TGF-β receptors

Satya Swarup Samal , Aurélien Naldi , Dima Grigoriev , Andreas Weber , Nathalie Théret et al.
BioSystems, 2016, 149, pp.3-14. ⟨10.1016/j.biosystems.2016.07.004⟩
Article dans une revue hal-01379033 v1

Maximal switchability of centralized networks

Sergei Vakulenko , Ivan Morozov , Ovidiu Radulescu
Nonlinearity, 2016, 29 (8), pp.2327-2354. ⟨10.1088/0951-7715/29/8/2327⟩
Article dans une revue hal-03644308 v1
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Analytic framework for a stochastic binary biological switch

Guilherme Innocentini , Sarah Guiziou , Jerome Bonnet , Ovidiu Radulescu
Physical Review E , 2016, 94 (6), pp.062413. ⟨10.1103/PhysRevE.94.062413⟩
Article dans une revue hal-03644297 v1

Stress diffusion in shear banding wormlike micelles

Marc-Antoine Fardin , Ovidiu Radulescu , Alexander Morozov , Olivier Cardoso , Julien Browaeys et al.
Journal of Rheology, 2015, 59 (6), pp.1335-1362. ⟨10.1122/1.4930858⟩
Article dans une revue hal-03195234 v1
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A constraint solving approach to model reduction by tropical equilibration

Sylvain Soliman , François Fages , Ovidiu Radulescu
Algorithms for Molecular Biology, 2014, 9 (1), pp.24. ⟨10.1186/s13015-014-0024-2⟩
Article dans une revue hal-01098530 v1

Tropical Geometries and Dynamics of Biochemical Networks Application to Hybrid Cell Cycle Models

Vincent Noël , Dima Grigoriev , Sergey A. Vakulenko , Ovidiu Radulescu
Electronic Notes in Theoretical Computer Science, 2012, 284, pp.75-91. ⟨10.1016/j.entcs.2012.05.016⟩
Article dans une revue hal-00714358 v1
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Reconciling molecular regulatory mechanisms with noise patterns of bacterial metabolic promoters in induced and repressed states

Matthew L. M. L. Ferguson , Dominique D. Le Coq , Matthieu Jules , Stephane S. Aymerich , Ovidiu O. Radulescu et al.
Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (1), pp.155 - 160. ⟨10.1073/pnas.1110541108⟩
Article dans une revue hal-01004232 v1
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Reduction of dynamical biochemical reaction networks in computational biology

Ovidiu Radulescu , Alexander N. Gorban , Andrei Zinovyev , Vincent Noël
Frontiers in Genetics, 2012, 131 (2), ⟨10.3389/fgene.2012.00131⟩
Article dans une revue hal-00770213 v1
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Convergence of stochastic gene networks to hybrid piecewise deterministic processes

Alina Crudu , Arnaud Debussche , Aurélie Muller , Ovidiu Radulescu
The Annals of Applied Probability, 2012, 22 (5), pp.1822-1859. ⟨10.1214/11-AAP814⟩
Article dans une revue hal-00553482 v1

Designing Logical Rules to Model the Response of Biomolecular Networks with Complex Interactions: An Application to Cancer Modeling.

Carito Guziolowski , Sylvain Blachon , Tatiana Baumuratova , Gautier Stoll , Ovidiu Radulescu et al.
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2011, 8 (5), pp.1223-1234. ⟨10.1109/TCBB.2010.71⟩
Article dans une revue inria-00538134 v1

Genetically regulated metabolic networks: Gale-Nikaido modules and differential inequalities

Ovidiu Radulescu , Anne Siegel , Elisabeth Pecou , Clément Chatelain , Sandrine Lagarrigue
Transactions on Computational Systems Biology, 2011, Transactions on Computational Systems Biology XIII, 6575 (Lecture Notes in Computer Science 6575), pp.110-130. ⟨10.1007/978-3-642-19748-2_6⟩
Article dans une revue istex inria-00538136 v1
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Localizing potentially active post-transcriptional regulations in the Ewing's sarcoma gene regulatory network.

Tatiana Baumuratova , Didier Surdez , Bernard Delyon , Gautier Stoll , Olivier Delattre et al.
BMC Systems Biology, 2010, 4 (1), pp.146. ⟨10.1186/1752-0509-4-146⟩
Article dans une revue inserm-00984711 v1

Asymptotology of Chemical Reaction Networks

Alexander N. Gorban , Ovidiu Radulescu , Andrei Zinovyev
Chemical Engineering Science, 2010, 65 (7), pp.2310-2324. ⟨10.1016/j.ces.2009.09.005⟩
Article dans une revue inria-00431225 v1
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A minimal model for hepatic fatty acid balance during fasting: Application to PPAR alpha-deficient mice

Pierre Blavy , Florence Gondret , Hervé Guillou , Sandrine Lagarrigue , P.G.P. Martin et al.
Journal of Theoretical Biology, 2009, 261 (2), pp.266. ⟨10.1016/j.jtbi.2009.07.025⟩
Article dans une revue hal-00559147 v1

Size Regulation in the Segmentation of Drosophila: Interacting Interfaces between Localized Domains of Gene Expression Ensure Robust Spatial Patterning

S.A. Vakulenko , Manu Manu , John Reinitz , Ovidiu Radulescu
Physical Review Letters, 2009, 103, pp.168102
Article dans une revue inria-00431224 v1
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Hybrid stochastic simplifications for multiscale gene networks

Alina Crudu , Arnaud Debussche , Ovidiu Radulescu
BMC Systems Biology, 2009, 3 (1), pp.89. ⟨10.1186/1752-0509-3-89⟩
Article dans une revue hal-00784449 v1

Canalization of gene expression in the Drosophila blastoderm by gap genes cross regulation

Manu Manu , Svetlana Surkova , Alexander V. Spirov , Vitaly Gursky , Hilde Janssens et al.
PLoS Biology, 2009, 7, pp.3
Article dans une revue inria-00431229 v1

Canalization of gene expression and domain shifts in the Drosophila blastoderm by dynamical attractors

Manu Manu , Svetlana Surkova , Alexander V. Spirov , Vitaly Gursky , Hilde Janssens et al.
PLoS Computational Biology, 2009, 5, pp.3
Article dans une revue inria-00431228 v1

From Molecules to Organisms: Towards Multiscale Integrated Models of Biological Systems

Christophe Lavelle , Hugues Berry , Guillaume Beslon , Francisco Ginelli , Jean-Louis Giavitto et al.
Theoretical Biology Insights, 2008, 1, pp.13-22
Article dans une revue inria-00331281 v1

Robust simplifications of multiscale biochemical networks

Ovidiu Radulescu , Alexander N. Gorban , Andrei Zinovyev , Alain Lilienbaum
BMC Systems Biology, 2008, 2:86
Article dans une revue inria-00331212 v1

Dynamic and static limitation in multiscale reaction networks, revisited

Alexander N. Gorban , Ovidiu Radulescu
Chemical Engineering Science, 2008, Advances in Chemical Engineering, 34, pp.103-173
Article dans une revue inria-00184976 v1

Inferring the role of transcription factors in regulatory networks

Philippe Veber , Carito Guziolowski , Michel Le Borgne , Ovidiu Radulescu , Anne Siegel
BMC Bioinformatics, 2008, 9, ⟨10.1186/1471-2105-9-228⟩
Article dans une revue inria-00330578 v1

Théorèmes limites pour des processus de Markov à sauts. Synthèse des résultats et applications en biologie moleculaire

Ovidiu Radulescu , Aurélie Muller , Alina Crudu
Revue des Sciences et Technologies de l'Information - Série TSI : Technique et Science Informatiques, 2007, 26 (3-4), pp.443-469. ⟨10.3166/tsi.26.443-469⟩
Article dans une revue istex inria-00181451 v1
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Checking Consistency Between Expression Data and Large Scale Regulatory Networks: A Case Study

Carito Guziolowski , Philippe Veber , Michel Le Borgne , Ovidiu Radulescu , Anne Siegel
Journal of Biological Physics and Chemistry, 2007, 7, pp.37-43
Article dans une revue inria-00178914 v1
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Optimiser un plan d'expérience à partir de modèles qualitatifs?

Anne Siegel , Carito Guziolowski , Philippe Veber , Ovidiu Radulescu , Michel Le Borgne
Biofutur, 2007, 275, pp.27-31
Article dans une revue inria-00178791 v1

Dynamical robustness of biological networks with hierarchical distribution of time scales

Alexander N. Gorban , Ovidiu Radulescu
IET Systems Biology, 2007
Article dans une revue inria-00181450 v1
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Topology and static response of interaction networks in molecular biology

Ovidiu Radulescu , Sandrine Lagarrigue , Anne Siegel , Philippe Veber , Michel Le Borgne
Journal of the Royal Society Interface, 2006, 3 (6), pp.185 - 196. ⟨10.1098/rsif.2005.0092⟩
Article dans une revue inria-00178842 v1
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Qualitative analysis of the relation between DNA microarray data and behavioral models of regulation networks

Anne Siegel , Ovidiu Radulescu , Michel Le Borgne , Philippe Veber , Julien Ouy et al.
BioSystems, 2006, 84, pp.153-174
Article dans une revue inria-00178809 v1

Complex Qualitative Models in Biology: a new approach

Philippe Veber , Michel Le Borgne , Anne Siegel , Sandrine Lagarrigue , Ovidiu Radulescu
Complexus, 2005, 2, pp.140-151
Article dans une revue inria-00178819 v1

Timescales in shear banding of wormlike micelles

Ovidiu Radulescu , Peter D. Olmsted , Jean-Paul Decruppe , Sandra Lerouge , Jean-François Berret et al.
EPL - Europhysics Letters, 2003, 62 (2), pp.230-236. ⟨10.1209/epl/i2003-00351-x⟩
Article dans une revue hal-00136480 v1

Dynamics of modulated and composite aperiodic crystals: the signature of the inner polarization in the neutron coherent inelastic scattering

Ovidiu Radulescu , T. Janssen , J. Etrillard
The European Physical Journal B: Condensed Matter and Complex Systems, 2002, 29, pp.385-398
Article dans une revue hal-00122070 v1
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A classification of the periodic directions in the rational approximants of icosahedral quasicrystals

Ovidiu Radulescu
Journal de Physique I, 1993, 3 (10), pp.2099-2113. ⟨10.1051/jp1:1993234⟩
Article dans une revue istex jpa-00246854 v1
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Efficient 3D Reconstruction of H&E Whole Slide Images in Melanoma

Janan Arslan , Mehdi Ounissi , Haocheng Luo , Matthieu Lacroix , Pierrick Dupré et al.
SPIE Medical Imaging 2023, Feb 2023, San Diego, California, United States
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Reconstruction vasculaire 3D et analyse de lames virtuelles H&E dans l'étude du mélanome

Janan Arslan , Haocheng Luo , Pawan Kumar , Matthieu Lacroix , Pierrick Dupré et al.
IABM2023 : Colloque Français d'Intelligence Artificielle en Imagerie Biomédicale, Mar 2023, Paris, France
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Mitotic Memory as Spontaneous Symmetry Breaking in the Cell

Arran Hodgkinson , Maelle Bellec , Maria Douaihy , Adrian Devenyi , Mounia Lagha et al.
International Conference in Systems Biology, Oct 2022, Berlin, Germany
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3D reconstruction and mathematical modelling of whole slide images to elucidate resistance to the targeted therapy in melanoma

Janan Arslan , Pawan Kumar , Arran Hodgkinson , Haocheng Luo , Pierrick Dupré et al.
International Conference in Systems Biology, Oct 2022, Berlin, Germany
Communication dans un congrès hal-03814995 v1

Data driven mechanistic modeling of oxygen distribution and hypoxia profile in tumor microenvironment

Pawan Kumar , Janan Arslan , Arran Hodgkinson , Haocheng Luo , Sarah Dandou et al.
COMPSYSCAN2022: A complex systems approach to cancer understanding, Oct 2022, Lyon, France
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Stochasticity of Meiotic Entry in Xenopus Oocytes

Deniz Fettahoglu , Charbel Choufani , Pawan Kumar , Anna Castro , Thierry Lorca et al.
International Conference in Systems Biology, Oct 2022, Berlin, Germany
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Introducing [MALMO]: Mathematical approaches to modelling metabolic plasticity and heterogeneity in Melanoma

Janan Arslan , Laurent Le Cam , Matthieu Lacroix , Emmanuel Faure , Pierrick Dupré et al.
RITS 2022 - Recherche en Imagerie et Technologie pour la Santé, May 2022, Brest, France
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LNetReduce: tool for reducing linear dynamic networks with separated time scales

Marion Buffard , Aurélien Desoeuvres , Aurélien Naldi , Clément Requilé , Andrei Zinovyev et al.
Computational Methods in Systems Biology, Sep 2021, Bordeaux, France. ⟨10.1007/978-3-030-85633-5_15⟩
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Tropical Geometry of Biological Systems

Ovidiu Radulescu
CASC 2020, Sep 2020, Linz, Austria
Communication dans un congrès hal-02949563 v1
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Interval Constraint Satisfaction and Optimization for Biological Homeostasis and Multistationarity

Aurélien Desoeuvres , Gilles Trombettoni , Ovidiu Radulescu
CMSB 2020 - 18th International Conference on Computational Methods in Systems Biology, Sep 2020, Konstanz, Germany. pp.79-101, ⟨10.1007/978-3-030-60327-4_5⟩
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Symbolic Versus Numerical Computation and Visualization of Parameter Regions for Multistationarity of Biological Networks

Matthew England , Hassan Errami , Dima Grigoriev , Ovidiu Radulescu , Thomas Sturm et al.
CASC 2017 - 19th International Workshop on Computer Algebra in Scientific Computing, Sep 2017, Beijing, China. ⟨10.1007/978-3-319-66320-3⟩
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A Case Study on the Parametric Occurrence of Multiple Steady States

Russell Bradford , James H. Davenport , Matthew England , Hassan Errami , Vladimir Gerdt et al.
ISSAC 2017 - International Symposium on Symbolic and Algebraic Computation, Jul 2017, Kaiserslautern, Germany. pp.45-52, ⟨10.1145/3087604.3087622⟩
Communication dans un congrès hal-01648694 v1

Tropicalization and tropical equilibration of chemical reactions

Vincent Noël , Dima Grigoriev , Sergey A. Vakulenko , Ovidiu Radulescu
International Workshop on Tropical and Idempotent Mathematics, Independent University of Moscow, Aug 2012, Moscow, Russia. pp.261-275, ⟨10.1090/conm/616/12316⟩
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A Constraint Solving Approach to Tropical Equilibration and Model Reduction

Sylvain Soliman , François Fages , Ovidiu Radulescu
WCB - ninth Workshop on Constraint Based Methods for Bioinformatics, colocated with CP 2013, Sep 2013, Uppsala, Sweden. pp.27--36
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Hybrid models of the cell cycle molecular machinery

Vincent Noël , Dima Grigoriev , Sergey A. Vakulenko , Ovidiu Radulescu
Hybrid Systems and Biology (HSB 2012), Sep 2012, Newcastle, United States. pp.88-105, ⟨10.4204/EPTCS.92⟩
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Two types of transcriptional repression in living cells of [i]Bacillus subtilis[/i] characterized by number and brightness analysis

Matthew L. Ferguson , Dominique Le Coq , Matthieu Jules , Bryan Chun , Stephane Aymerich et al.
55. Annual Meeting of the Biophysical-Society, Mar 2011, Baltimore, Maryland, United States. ⟨10.1016/j.bpj.2010.12.1179⟩
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Asymptotology of Chemical Reaction Networks

Alexander N. Gorban , Ovidiu Radulescu , Andrei Zinovyev
International Symposium on Mathematics in Chemical Kinetics and Engineering (MACKIE-2009), Nov 2009, Ghent, Belgium
Communication dans un congrès inria-00599258 v1
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CURATING A LARGE-SCALE REGULATORY NETWORK BY EVALUATING ITS CONSISTENCY WITH EXPRESSION DATASETS

Carito Guziolowski , Jérémy Gruel , Ovidiu Radulescu , Anne Siegel
CIBB 2008: COMPUTATIONAL INTELLIGENCE METHODS FOR BIOINFORMATICS AND BIOSTATISTICS, Oct 2008, Salerno, Italy. pp.144-155
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Method for Relating Inter-patient Gene Copy Numbers Variations with Gene Expression via Gene Influence Networks

Sylvain Blachon , Gautier Stoll , Carito Guziolowski , Andrei Zinovyev , Emmanuel Barillot et al.
AIAI 2009 Workshop -- Workshop on Biomedical Informatics and Intelligent Approaches in the Support of Genomic Medicine (BMIINT), Apr 2009, Thessalonik, Greece. pp.72-87
Communication dans un congrès inria-00429801 v1
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A minimal and dynamic model for fatty acid metabolism in mouse liver

Pierre Blavy , Florence Gondret , Hervé Guillou , Sandrine Lagarrigue , Pascal G.P. Martin et al.
Journées Ouvertes de Biologie, Informatique et Mathématique (JOBIM), Jun 2008, Lille (FR), France
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Timescales and instabilities of shear thinning solutions of wormlike micelles

Ovidiu Radulescu , Sandra Lerouge , Benoit Lasne
15th International Congress on Rheology 2008, Aug 2008, Monterey, United States. pp.CF36
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Qualitative response of interaction networks: application to the validation of biological models

Anne Siegel , Carito Guziolowski , Philippe Veber , Ovidiu Radulescu , Michel Le Borgne
6th International Congress on Industrial and Applied Mathematics. ICIAM 07, Jul 2007, Zurich, Switzerland
Communication dans un congrès inria-00178854 v1

Modélisation multi-organes et multi-espèces du métabolisme des lipides

Pierre Blavy , Anne Siegel , Ovidiu Radulescu , Florence Gondret , Jaap J. van Milgen et al.
2. Journées d'Animation Scientifique du Département PHASE, Oct 2007, Tours, France
Communication dans un congrès hal-02756643 v1

A Linear Algebra Approach for Detecting Binomiality of Steady State Ideals of Reversible Chemical Reaction Networks

Hamid Rahkooy , Ovidiu Radulescu , Thomas Sturm
Computer Algebra in Scientific Computing: 22nd International Workshop - CASC 2020, pp.492-509, 2020, ⟨10.1007/978-3-030-60026-6_29⟩
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Tropical Geometry of Biological Systems (Invited Talk)

Ovidiu Radulescu
Computer Algebra in Scientific Computing, 12291, Springer International Publishing, pp.1-13, 2020, Lecture Notes in Computer Science, ⟨10.1007/978-3-030-60026-6_1⟩
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Integrative models for TGF-$\beta$ signaling and extracellular matrix

Nathalie Theret , Jérôme Feret , Arran Hodgkinson , Pierre Boutillier , Pierre Vignet et al.
Sylvie Ricard-Blum. Extracellular Matrix Omics, 7, Springer, pp.17, 2020, Biology of Extracellular Matrix, 978-3-030-58329-3. ⟨10.1007/978-3-030-58330-9_10⟩
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Metastable Regimes and Tipping Points of Biochemical Networks with Potential Applications in Precision Medicine

Satya Swarup Samal , Jeyashree Krishnan , Ali Hadizadeh Esfahani , Christoph Lüders , Andreas Weber et al.
Automated Reasoning for Systems Biology and Medicine, 30, Springer International Publishing, pp.269-295, 2019, Computational Biology, ⟨10.1007/978-3-030-17297-8_10⟩
Chapitre d'ouvrage hal-03644180 v1

Effective Computational Methods for Hybrid Stochastic Gene Networks

Ovidiu Radulescu , Guilherme Innocentini , Fernando Antoneli , Arran Hodgkinson
Computational Methods in Systems Biology, 11773 (21-22), Springer International Publishing, pp.60-77, 2019, Lecture Notes in Computer Science, ⟨10.1007/978-3-030-31304-3_4⟩
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Mathematical Modeling and Omic Data Integration to Understand Dynamic Adaptation of Apicomplexan Parasites and Identify Pharmaceutical Targets

Partho Sen , Henri Vial , Ovidiu Radulescu
Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery, Wiley-VCH Verlag GmbH & Co. KGaA, pp.455-486, 2016, ⟨10.1002/9783527694082.ch20⟩
Chapitre d'ouvrage hal-03644305 v1

Hybrid Reductions of Computational Models of Ion Channels Coupled to Cellular Biochemistry

Jasha Sommer-Simpson , John Reinitz , Leonid Fridlyand , Louis Philipson , Ovidiu Radulescu
Computational Methods in Systems Biology, 9859, Springer International Publishing, pp.273-288, 2016, Lecture Notes in Computer Science, ⟨10.1007/978-3-319-45177-0_17⟩
Chapitre d'ouvrage hal-03644304 v1

Algorithm for identification of piecewise smooth hybrid systems: application to Eukaryotic Cell Cycle regulation

Vincent Noël , Sergey A. Vakulenko , Ovidiu Radulescu
Teresa Przytycka, Marie-France Sagot. Algorithms in Bioinformatics, Springer, pp.225-236, 2011, Lecture Notes in Computer Science, vol. 6833, 9783642230370. ⟨10.1007/978-3-642-23038-7_20⟩
Chapitre d'ouvrage istex hal-00725282 v1

Dissecting the dynamics of coordinated active transcriptional repression in a multicellular organism

Virginia Pimmett , Maria Douaihy , Louise Maillard , Antonio Trullo , Jeremy Dufourt et al.
2024
Pré-publication, Document de travail hal-04730394 v1
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Mathematical Basis and Toolchain for Hierarchical Optimization of Biochemical Networks

Nisha Ann Viswan , Alexandre Tribut , Manvel Gasparyan , Ovidiu Radulescu , Upinder S Bhalla
2024
Pré-publication, Document de travail hal-04593669 v4

Diverse and weakly immunogenic var gene expression facilitates malaria infection

Inayat Bhardwaj , Prince Nyarko , Asrar Ba Ashn , Camille Cohen , Sukai Ceesay et al.
2025
Pré-publication, Document de travail hal-04958548 v1
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Improved prediction of the response duration to MAPK inhibitors in patients with advanced melanoma using baseline genomic data and machine learning algorithms

Sarah Dandou , Kriti Amin , Véronique D’hondt , Jérôme Solassol , Olivier Dereure et al.
2023
Pré-publication, Document de travail hal-04781510 v1

Quantitative imaging of transcription in living Drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics

Virginia Pimmett , Matthieu Dejean , Carola Fernandez , Antonio Trullo , Edouard Bertrand et al.
2021
Pré-publication, Document de travail hal-03155482 v1

The control of transcriptional memory by stable mitotic bookmarking

Mounia Lagha , Maëlle Bellec , Jérémy Dufourt , George Hunt , Hélène Lenden-Hasse et al.
2021
Pré-publication, Document de travail hal-03442288 v1
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Stochastic pausing at latent HIV-1 promoters generates transcriptional bursting

Katiana Tantale , Encarnation Garcia-Oliver , Adèle L'Hostis , Yueyuxio Yang , Marie- Cécile Robert et al.
2020
Pré-publication, Document de travail hal-03019157 v1

A Linear Algebra Approach for Detecting Binomiality of Steady State Ideals of Reversible Chemical Reaction Networks

Hamid Rahkooy , Ovidiu Radulescu , Thomas Sturm
2020
Pré-publication, Document de travail hal-03017913 v1

Algorithmic Reduction of Biological Networks With Multiple Time Scales

Niclas Kruff , Christoph Lüders , Ovidiu Radulescu , Thomas Sturm , Sebastian Walcher
2020
Pré-publication, Document de travail hal-02977490 v1

A hybrid mammalian cell cycle model

Vincent Noël , Sergey Vakulenko , Ovidiu Radulescu
2013
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