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Ovidiu Radulescu
116
Documents
Presentation
**EDUCATION
Habilitation in Applied Mathematics (University of Rennes 1, 11/12/2006)
Master degree in Probability theory and analysis (University of Marne-la-Vallée, 1996)
PhD in Theoretical Solid State Physics (Orsay, University of Paris 11, 1994)
Engineering degree in Solid State Physics (University of Bucharest, 1989)
PROFESSIONAL CAREER
====================
**Current position :** Full Professor (Professeur classe exceptionnelle), Team leader in the Laboratory of Pathogen Host Interactions (LPHI) UMR 5235, University of Montpellier, since 2009.
**Other positions**
01/09/1999-31/08/2009, Institute for Mathematical Research (IRMAR), University of Rennes 1, Rennes, France, Associate Professor in mathematics (MCF classe normale, CNU26)
01/09/2005-31/08/2007, National Institute for Computer Science and Applied Mathematics (INRIA), team SYMBIOSE, Rennes, France, Visiting professor (secondment, délégation).
01/03/1998-31/08/2009, IRC in Polymer Physics and Department of Physics, University of Leeds, Leeds, UK, Post-doc in theoretical polymer physics.
01/03/1996-28/02/1998 Institute of Theoretical Physics, Raadboud University, Nijmegen, The Netherlands, HCM EU fellow in theoretical condensed matter physics.
01/09/1993-28/02/1996, University of Marne-la-Vallée, Noisy le Grand, France, Assistant Professor (untenured teaching and research position, ATER) in theoretical condensed matter physics.
01/09/1990-31/08/1993, University of Paris 11, Orsay, France, Teaching assistant (Moniteur).
01/01/1990-31/08/1990, Institute of Research on Materials, Bucharest, Romania, Researcher in theoretical condensed matter theory.
**Recent Management Activities:**
Member of the Councils of University of Rennes 1 (2008-2009) and University of Montpellier (2011-2015); Adjoint chief of the BioHealth Department at University of Montpellier (2013-2014)
**Participation to National and International Scientific Networks Management**
Coordinator of the Interdisciplinary axis of Pole Rabelais; Member of Labex Epigenmed; Member of the international network IPols (International Physics of Living Systems Program).
**Participation to National and International Expert Committees**
Expert for ERC (European Research Council), ANR (French National Research Agency), HCERES (High Council for the Evaluation of Research and Higher Education), NW0 (Netherlands Organisation for Scientific Research)
Member of the interdisciplinary committee CID51 of CNRS (2013-2016).
**Editorial activity:**
Associated Editor of Frontiers in Bioinformatics and Computational Biology.
**Participation to program committees (PC) of international conferences:**
Member of the PC of the International Workshop on Static Analysis and Systems Biology SASB (2011-12)
Member of the PC of the International Conference on Computational Methods in Systems Biology CMSB (2011-12, 2015-20)
Member of the PC of the Workshop on Interactions between Computer Science and Biology CS2BIO (2014)
Member of the PC of the IEEE International Conference on Computational Intelligence in Bioinformatics and Computational Biology CIBCB (2019-20)
**Supervision:**
Supervision of 10 phD students, 31 master students, 5 post-docs
Direction of the master program “Biophysics Structure and Systems”
**Recent invited international conferences:**
1\) **Keynote talk**, CASC 2020 (Computer Algebra in Scientific Computing), Linz, Austria, Sept 14-18, 2020.
2\) **Plenary invited talk**, Workshop on Robustness, Heterogeneity and Adaptation, Gordon Center for Integrative Sciences, University of Chicago, June 20-21, 2016.
3\) **Plenary invited talk**, Symmetry and Dynamics in Biology, Paulista Medical School, (EPM – Unifesp), São Paulo -SP-Brazil, April 17, 2015.
4\) **Plenary invited talk**, workshop Mathematical Trends in Reaction Network Theory, Copenhagen, July 1-3, 2015.
5\) **Plenary invited talk**, Applications of statistical physics in quantitative biology mini-symposium, 9th European Conference on Mathematical and Theoretical Biology, Gothenburg, Sweden, 2014.
6\) **Invited talk**, Franco-Indian Technology Summit, IT & Health, 24 Octobre 2013, New Delhi, India.
7\) **Keynote talk**, 9th BioMalPar - Evimalar Conference, 13-15 Octobre 2013, EMBL Heidelberg, Germany.
HONORSANDAWARDS
================
Medals at International Physics Olympiads (1981 bronze, 1982 silver); BGF (French government) fellow (1990-94); DAAD fellow (1995); HCM EU fellow (1996-98); bonus for scientific excellence (PES, PEDR) since 2009.
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Efficient 3D Reconstruction of H&E Whole Slide Images in MelanomaSPIE Medical Imaging 2023, Feb 2023, San Diego, California, United States
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Reconstruction vasculaire 3D et analyse de lames virtuelles H&E dans l'étude du mélanomeIABM2023 : Colloque Français d'Intelligence Artificielle en Imagerie Biomédicale, Mar 2023, Paris, France
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Stochasticity of Meiotic Entry in Xenopus OocytesInternational Conference in Systems Biology, Oct 2022, Berlin, Germany
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Data driven mechanistic modeling of oxygen distribution and hypoxia profile in tumor microenvironmentCOMPSYSCAN2022: A complex systems approach to cancer understanding, Oct 2022, Lyon, France
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3D reconstruction and mathematical modelling of whole slide images to elucidate resistance to the targeted therapy in melanomaInternational Conference in Systems Biology, Oct 2022, Berlin, Germany
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Introducing [MALMO]: Mathematical approaches to modelling metabolic plasticity and heterogeneity in MelanomaRITS 2022 - Recherche en Imagerie et Technologie pour la Santé, May 2022, Brest, France
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Mitotic Memory as Spontaneous Symmetry Breaking in the CellInternational Conference in Systems Biology, Oct 2022, Berlin, Germany
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LNetReduce: tool for reducing linear dynamic networks with separated time scalesComputational Methods in Systems Biology, Sep 2021, Bordeaux, France. ⟨10.1007/978-3-030-85633-5_15⟩
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Tropical Geometry of Biological SystemsCASC 2020, Sep 2020, Linz, Austria
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Interval Constraint Satisfaction and Optimization for Biological Homeostasis and MultistationarityCMSB 2020 - 18th International Conference on Computational Methods in Systems Biology, Sep 2020, Konstanz, Germany. pp.79-101, ⟨10.1007/978-3-030-60327-4_5⟩
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A Case Study on the Parametric Occurrence of Multiple Steady StatesISSAC 2017 - International Symposium on Symbolic and Algebraic Computation, Jul 2017, Kaiserslautern, Germany. pp.45-52, ⟨10.1145/3087604.3087622⟩
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Symbolic Versus Numerical Computation and Visualization of Parameter Regions for Multistationarity of Biological NetworksCASC 2017 - 19th International Workshop on Computer Algebra in Scientific Computing, Sep 2017, Beijing, China. ⟨10.1007/978-3-319-66320-3⟩
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A Constraint Solving Approach to Tropical Equilibration and Model ReductionWCB - ninth Workshop on Constraint Based Methods for Bioinformatics, colocated with CP 2013, Sep 2013, Uppsala, Sweden. pp.27--36
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Hybrid models of the cell cycle molecular machineryHybrid Systems and Biology (HSB 2012), Sep 2012, Newcastle, United States. pp.88-105, ⟨10.4204/EPTCS.92⟩
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Tropicalization and tropical equilibration of chemical reactionsInternational Workshop on Tropical and Idempotent Mathematics, Independent University of Moscow, Aug 2012, Moscow, Russia. pp.261-275, ⟨10.1090/conm/616/12316⟩
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Two types of transcriptional repression in living cells of [i]Bacillus subtilis[/i] characterized by number and brightness analysis55. Annual Meeting of the Biophysical-Society, Mar 2011, Baltimore, Maryland, United States. ⟨10.1016/j.bpj.2010.12.1179⟩
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Method for Relating Inter-patient Gene Copy Numbers Variations with Gene Expression via Gene Influence NetworksAIAI 2009 Workshop -- Workshop on Biomedical Informatics and Intelligent Approaches in the Support of Genomic Medicine (BMIINT), Apr 2009, Thessalonik, Greece. pp.72-87
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Asymptotology of Chemical Reaction NetworksInternational Symposium on Mathematics in Chemical Kinetics and Engineering (MACKIE-2009), Nov 2009, Ghent, Belgium
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CURATING A LARGE-SCALE REGULATORY NETWORK BY EVALUATING ITS CONSISTENCY WITH EXPRESSION DATASETSCIBB 2008: COMPUTATIONAL INTELLIGENCE METHODS FOR BIOINFORMATICS AND BIOSTATISTICS, Oct 2008, Salerno, Italy. pp.144-155
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inria-00331385v1
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Timescales and instabilities of shear thinning solutions of wormlike micelles15th International Congress on Rheology 2008, Aug 2008, Monterey, United States. pp.CF36
Conference papers
inria-00331217v1
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A minimal and dynamic model for fatty acid metabolism in mouse liverJournées Ouvertes de Biologie, Informatique et Mathématique (JOBIM), Jun 2008, Lille (FR), France
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Modélisation multi-organes et multi-espèces du métabolisme des lipides2. Journées d'Animation Scientifique du Département PHASE, Oct 2007, Tours, France
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Qualitative response of interaction networks: application to the validation of biological models6th International Congress on Industrial and Applied Mathematics. ICIAM 07, Jul 2007, Zurich, Switzerland
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Estimating spatial distribution of oxygen and hypoxia in tumor microenvironment: a mechanistic approachConference poster hal-04021831v1 |
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The SYMBIONT Project: Symbolic Methods for Biological NetworksISSAC 2018, Jul 2018, New York City, NY, United States
Conference poster
hal-02397143v1
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Comprehensive Analysis of Parasite Biology: From Metabolism to Drug DiscoveryWiley-VCH Verlag GmbH & Co. KGaA, 2016, ⟨10.1002/9783527694082⟩
Books
hal-03644343v1
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Integrative models for TGF-$\beta$ signaling and extracellular matrixSylvie Ricard-Blum. Extracellular Matrix Omics, 7, Springer, pp.17, 2020, Biology of Extracellular Matrix, 978-3-030-58329-3. ⟨10.1007/978-3-030-58330-9_10⟩
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Tropical Geometry of Biological Systems (Invited Talk)Computer Algebra in Scientific Computing, 12291, Springer International Publishing, pp.1-13, 2020, Lecture Notes in Computer Science, ⟨10.1007/978-3-030-60026-6_1⟩
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hal-03644251v1
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A Linear Algebra Approach for Detecting Binomiality of Steady State Ideals of Reversible Chemical Reaction NetworksComputer Algebra in Scientific Computing: 22nd International Workshop - CASC 2020, pp.492-509, 2020, ⟨10.1007/978-3-030-60026-6_29⟩
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hal-02977486v1
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Metastable Regimes and Tipping Points of Biochemical Networks with Potential Applications in Precision MedicineAutomated Reasoning for Systems Biology and Medicine, 30, Springer International Publishing, pp.269-295, 2019, Computational Biology, ⟨10.1007/978-3-030-17297-8_10⟩
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Effective Computational Methods for Hybrid Stochastic Gene NetworksComputational Methods in Systems Biology, 11773 (21-22), Springer International Publishing, pp.60-77, 2019, Lecture Notes in Computer Science, ⟨10.1007/978-3-030-31304-3_4⟩
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Hybrid Reductions of Computational Models of Ion Channels Coupled to Cellular BiochemistryComputational Methods in Systems Biology, 9859, Springer International Publishing, pp.273-288, 2016, Lecture Notes in Computer Science, ⟨10.1007/978-3-319-45177-0_17⟩
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Mathematical Modeling and Omic Data Integration to Understand Dynamic Adaptation of Apicomplexan Parasites and Identify Pharmaceutical TargetsComprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery, Wiley-VCH Verlag GmbH & Co. KGaA, pp.455-486, 2016, ⟨10.1002/9783527694082.ch20⟩
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Algorithm for identification of piecewise smooth hybrid systems: application to Eukaryotic Cell Cycle regulationTeresa Przytycka, Marie-France Sagot. Algorithms in Bioinformatics, Springer, pp.225-236, 2011, Lecture Notes in Computer Science, vol. 6833, 9783642230370. ⟨10.1007/978-3-642-23038-7_20⟩
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The SYMBIONT Project: Symbolic Methods for Biological Networks2018
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French Roadmap for complex Systems 2008-20092009
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Symbolic Methods for Biological Networks D2.1 Report on Scalable Methods for Tropical Solutions (T1.2)[Research Report] Inria Saclay. 2022
Reports
hal-03648027v1
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Checking Consistency Between Expression Data and Large Scale Regulatory Networks: A Case Study[Research Report] RR-6190, INRIA. 2007, pp.14
Reports
inria-00145537v2
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Inferring the role of transcription factors in regulatory networks[Research Report] 2007
Reports
inria-00185038v1
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