Pascal Arnoux

Documents

Publications

Pseudopaline-mediated zinc uptake by Pseudomonas aeruginosa drives clinically relevant phenotypes and infection outcomes

Lola Bosc , Thomas Sécher , Genevieve Ball , Deborah Le Pennec , Mathilde Tribout et al.

Infection and Immunity, 2026, 94 (2), pp.e00453-25. ⟨10.1128/iai.00453-25⟩

Article dans une revue hal-05458347v1

Pseudogenization of the cntQ permease confers distinct yersinopine-metal uptake selectivity in Yersinia species

Clémentine Laffont , Elizabeth Pradel , Laurent Ouerdane , Amélie Dewitte , Nicolas Oswaldo Gomez et al.

BioMetals, In press, ⟨10.1007/s10534-026-00816-8⟩

Article dans une revue hal-05660427v1

Sec Signal Peptide Doubles Up as a Leader Sequence in Bufferin Biosynthesis

Sophie Jünger , Laura Leprevost , Severine Zirah , Chloé Carassus , Pascal Arnoux et al.

ACS Chemical Biology, 2026, 21 (6), pp.1309-1318. ⟨10.1021/acschembio.6c00045⟩

Article dans une revue hal-05732316v1

A new family of TonB-dependent copper transporters linked to respiratory oxidase function

Majda Hachmi , Manon Mirgaux , René Wintjens , Chloé Carassus , Pascal Arnoux et al.

Journal of Biological Chemistry, 2026, 302 (3), pp.111180. ⟨10.1016/j.jbc.2026.111180⟩

Article dans une revue hal-05502055v1

Acclimation of Photosynthesis to the Environment 1 acts as a copper-binding superoxide detoxification enzyme

Soazig Malesinski , André Vidal-Meireles , Eve Giovannetti , Marie Chazaux , Anja Krieger-Liszkay et al.

Nature Communications, 2026, 17 (1), pp.5192. ⟨10.1038/s41467-026-71893-z⟩

Article dans une revue hal-05759906v1

Quantitative mapping of methionine sensitivity to oxidation in the copper-bound PcuC chaperone

Lionel Tarrago , Lise Molinelli , Maya Belghazi , Mathilde Tribout , David Lemaire et al.

Redox Biology, 2026, 90, pp.104037. ⟨10.1016/j.redox.2026.104037⟩

Article dans une revue hal-05482074v1

A scaffold for quinone channeling between membrane and soluble bacterial oxidoreductases

M. Broc , M. Cherrier , A. Uzel , R. Arias-Cartin , P. Arnoux et al.

Nature Structural and Molecular Biology, 2025, 32, pp.2196-2202. ⟨10.1038/s41594-025-01607-4⟩

Article dans une revue hal-05229188v1

Discovery and characterization of UipA, a uranium- and iron-binding PepSY protein involved in uranium tolerance by soil bacteria

Nicolas Gallois , Béatrice Alpha-Bazin , Nicolas Bremond , Philippe Ortet , mohamed Barakat et al.

The International Society of Microbiologial Ecology Journal, 2022, 16 (3), pp.705-716. ⟨10.1038/s41396-021-01113-7⟩

Article dans une revue hal-03355370v1

Periplasmic Bacterial Biomineralization of Copper Sulfide Nanoparticles

Yeseul Park , Zohar Eyal , Péter Pekker , Daniel M. Chevrier , Christopher T Lefèvre et al.

Advanced Science, 2022, 9 (28), pp.2203444. ⟨10.1002/advs.202203444⟩

Article dans une revue hal-03830264v1

A novel enterococcus faecalis heme transport regulator (FhtR) senses host heme to control its intracellular homeostasis

Vincent Saillant , Damien Lipuma , Emeline Ostyn , Laetitia Joubert , Alain Boussac et al.

mBio, 2021, 12 (1), pp.e03392-20. ⟨10.1128/mBio.03392-20⟩

Article dans une revue hal-03141621v1

Involvement of the Pseudomonas aeruginosa MexAB–OprM efflux pump in the secretion of the metallophore pseudopaline

Nicolas Oswaldo Gomez , Alexandre Tetard , Laurent Ouerdane , Clémentine Laffont , Catherine Brutesco et al.

Molecular Microbiology, 2021, 115 (1), pp.84-98. ⟨10.1111/mmi.14600⟩

Article dans une revue hal-02957366v1

Mechanism and dynamics of fatty acid photodecarboxylase

Damien Sorigué , Kyprianos Hadjidemetriou , S. Blangy , G. Gotthard , A. Bonvalet et al.

Science, 2021, 372 (6538), pp.eabd5687. ⟨10.1126/science.abd5687⟩

Article dans une revue hal-03208662v1

Reduction of Protein Bound Methionine Sulfoxide by a Periplasmic Dimethyl Sulfoxide Reductase

Lionel Tarrago , Sandrine Grosse , David Lemaire , Laetitia Faure , Mathilde Tribout et al.

Antioxidants , 2020, 9 (7), pp.616. ⟨10.3390/antiox9070616⟩

Article dans une revue hal-02904811v1

Synthesis of Two Epimers of Pseudopaline

Gregorio Cullia , Roberto Fanelli , Romé Voulhoux , Pascal Arnoux , Florine Cavelier

European Journal of Organic Chemistry, 2020, 2020 (26), pp.3975-3980. ⟨10.1002/ejoc.202000278⟩

Article dans une revue cea-02962458v1

The ancient roots of nicotianamine: diversity, role, regulation and evolution of nicotianamine-like metallophores

Clémentine Laffont , Pascal Arnoux

Metallomics, 2020, 12 (10), pp.1480-1493. ⟨10.1039/D0MT00150C⟩

Article dans une revue cea-03125731v1

Simple rules govern the diversity of bacterial nicotianamine-like metallophores

Clémentine Laffont , Catherine Brutesco , Christine Hajjar , Gregorio Cullia , Roberto Fanelli et al.

Biochemical Journal, 2019, 476 (15), pp.2221-2233. ⟨10.1042/bcj20190384⟩

Article dans une revue cea-02275929v1

Tuning the redox properties of a [4Fe-4S] center to modulate the activity of Mo-bisPGD periplasmic nitrate reductase

Kamal Zeamari , Guillaume Gerbaud , Sandrine Grosse , Vincent Fourmond , Florence Chaspoul et al.

Biochimica biophysica acta (BBA) - Bioenergetics, 2019, 1860 (5), pp.402-413. ⟨10.1016/j.bbabio.2019.01.003⟩

Article dans une revue hal-02106668v1

Crystal structure of the transcriptional repressor DdrO: insight into the metalloprotease/repressor-controlled radiation response in Deinococcus

Arjan de Groot , Marina I. Siponen , Romaric Magerand , Nicolas Eugenie , Raquel Martin-Arevalillo et al.

Nucleic Acids Research, 2019, 47 (21), pp.11403-11417. ⟨10.1093/nar/gkz883⟩

Article dans une revue cea-02315882v1

Control by Metals of Staphylopine Dehydrogenase Activity during Metallophore Biosynthesis

Christine Hajjar , Roberto Fanelli , Clémentine Laffont , Catherine Brutesco , Gregorio Cullia et al.

Journal of the American Chemical Society, 2019, 141 (3), pp.5555-5562. ⟨10.1021/jacs.9b01676⟩

Article dans une revue cea-02078121v1

Independent and cooperative regulation of staphylopine biosynthesis and trafficking by Fur and Zur

Clémentine Fojcik , Marina Aigle , Laura Alfonsi , Elise Borezee-Durant , Pascal Arnoux et al.

Molecular Microbiology, 2018, ⟨10.1111/mmi.13927⟩

Article dans une revue hal-01710600v1

$Rhodobacter\ sphaeroides$ methionine sulfoxide reductase P reduces $R$ ‑ and $S$ ‑diastereomers of methionine sulfoxide from a broad‑spectrum of protein substrates

Lionel Tarrago , Sandrine Grosse , Marina I. Siponen , David Lemaire , Béatrice Alonso et al.

Biochemical Journal, 2018, 475 (23), pp.3779-3795. ⟨10.1042/BCJ20180706⟩

Article dans une revue cea-01936753v1

An algal photoenzyme converts fatty acids to hydrocarbons

Damien Sorigué , Bertrand Legeret , Stéphan Cuiné , Stephanie Blangy , Solène Y. Moulin et al.

Science, 2017, 357 (6354), pp.903 - 907. ⟨10.1126/science.aan6349⟩

Article dans une revue hal-01775093v1

Pseudomonas aeruginosa zinc uptake in chelating environment is primarily mediated by the metallophore pseudopaline

Sebastien Lhospice , Nicolas Oswaldo Gomez , Laurent Ouerdane , Catherine Brutesco , Ghassan Ghssein et al.

Scientific Reports, 2017, 7 (1), pp.1-10. ⟨10.1038/s41598-017-16765-9⟩

Article dans une revue hal-01679478v1

Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus

Ghassan Ghssein , Catherine Brutesco , Laurent Ouerdane , Clémentine Fojcik , Amélie Izaute et al.

Science, 2016, 352 (6289), pp.1105-1109. ⟨10.1126/science.aaf1018⟩

Article dans une revue hal-03133612v1

Sulphur shuttling across a chaperone during molybdenum cofactor maturation

Pascal Arnoux , Christian Ruppelt , Flore Oudouhou , Jérôme Lavergne , Marina I. Siponen et al.

Nature Communications, 2015, 6, pp.6148. ⟨10.1038/ncomms7148⟩

Article dans une revue hal-01452068v1

MamA as a Model Protein for Structure-Based Insight into the Evolutionary Origins of Magnetotactic Bacteria

Natalie Zeytuni , Samuel Cronin , Christopher T. Lefèvre , Pascal Arnoux , Dror Baran et al.

PLoS ONE, 2015, ⟨10.1371/journal.pone.0130394.s006⟩

Article dans une revue hal-01201844v1

Reductive activation in periplasmic nitrate reductase involves chemical modifications of the Mo-cofactor beyond the first coordination sphere of the metal ion

Julien G.J. Jacques , Vincent Fourmond , Pascal Arnoux , Monique Sabaty , Emilien Etienne et al.

Biochimica biophysica acta (BBA) - Bioenergetics, 2014, 1837 (2), pp.277 - 286. ⟨10.1016/j.bbabio.2013.10.013⟩

Article dans une revue hal-01481487v1

Cu binding by the Escherichia coli metal-efflux accessory protein RcnB

Camille Bleriot , Manon Gault , Erwan Gueguen , Pascal Arnoux , David Pignol et al.

Metallomics, 2014, 6 (8), pp.1400 - 1409. ⟨10.1039/c4mt00036f⟩

Article dans une revue hal-01652718v1

Comparative genomic analysis provides insights into the evolution and niche adaptation of marine Magnetospira sp. QH-2 strain

Boyang Ji , Sheng-Da Zhang , Pascal Arnoux , Zoe Rouy , François Alberto et al.

Environmental Microbiology, 2014, 16 (2), pp.525-544. ⟨10.1111/1462-2920.12180⟩

Article dans une revue istex hal-02463127v1

Kinetics of substrate inhibition of periplasmic nitrate reductase

Julien G.J. Jacques , Bénédicte Burlat , Pascal Arnoux , Monique Sabaty , Bruno Guigliarelli et al.

Biochimica biophysica acta (BBA) - Bioenergetics, 2014, BBA Bioenergetics, 1837 (10), pp.1801 - 1809. ⟨10.1016/j.bbabio.2014.05.357⟩

Article dans une revue hal-01494456v1

Structural insight into magnetochrome-mediated magnetite biomineralization

Marina I. Siponen , Pierre Legrand , Marc Widdrat , Stephanie Jones , Wei-Jia Zhang et al.

Nature, 2013, 502 (7473), pp.681-684. ⟨10.1038/nature12573⟩

Article dans une revue cea-02074556v1

Cardiolipin-based respiratory complex activation in bacteria.

Rodrigo Arias‐cartin , Stephane Grimaldi , Janine Pommier , P. Lanciano , C. Schaefer et al.

Proceedings of the National Academy of Sciences of the United States of America, 2011, 19 (108), pp.7781-7786

Article dans une revue hal-00677353v1

The crystallographic structure of thermoNicotianamine synthase with a synthetic reaction intermediate highlights the sequential processing mechanism

Cyril Dreyfus , Manuel Larrouy , Florine Cavelier , Jean Martinez , David Pignol et al.

Chemical Communications, 2011, 47, pp.5825-5827. ⟨10.1039/c1cc10565e⟩

Article dans une revue hal-00599286v1

Reassessing the Strategies for Trapping Catalytic Intermediates during Nitrate Reductase Turnover

Vincent Fourmond , Monique Sabaty , Pascal Arnoux , Patrick Bertrand , David Pignol et al.

Journal of Physical Chemistry B, 2010, 9 (114), pp.3341-3347

Article dans une revue hal-00677469v1

Correcting for Electrocatalyst Desorption and Inactivation in Chronoamperometry Experiments

Vincent Fourmond , Thomas Lautier , Carole Baffert , Fanny Leroux , Pierre-Pol Liebgott et al.

Analytical Chemistry, 2009, 81 (8), pp.2962 - 2968. ⟨10.1021/ac8025702⟩

Article dans une revue hal-01825488v1

Crystallographic snapshots of iterative substrate translocations during nicotianamine synthesis in Archaea.

Cyril Dreyfus , David Lemaire , Stéphane Mari , David Pignol , Pascal Arnoux

Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 (38), pp.16180-4. ⟨10.1073/pnas.0904439106⟩

Article dans une revue hal-00445313v1

Crystal structures of an Extracytoplasmic Solute Receptor from a TRAP transporter in its open and closed forms reveal a helix-swapped dimer requiring a cation for alpha-keto acid binding.

Sophie Gonin , Pascal Arnoux , Bénédicte Pierru , Jérôme Lavergne , Béatrice Alonso et al.

BMC Structural Biology, 2007, 7, pp.11. ⟨10.1186/1472-6807-7-11⟩

Article dans une revue cea-00164193v1

“Access to the Active Site of Periplasmic Nitrate Reductase: Insights from Site-Directed Mutagenesis and Zinc Inhibition Studies”

S. Dementin , Pascal Arnoux , B. Frangioni , S. Grosse , Christophe Léger et al.

Biochemistry, 2007, 38, pp.12240

Article dans une revue hal-00336040v1

“Effects of slow substrate binding and release in redox enzymes: theory and application to periplasmic nitrate reductase.

Pierre Bertrand , B. Frangioni , S. Dementin , M. Sabaty , Pascal Arnoux et al.

Journal of Physical Chemistry B, 2007, 111, pp.10300

Article dans une revue hal-00336030v1

“In Rhodobacter sphaeroides respiratory nitrate reductase, the kinetics of substrate binding favors intramolecular electron transfer”

B. Frangioni , Pascal Arnoux , Monique Sabaty , David Pignol , Patrick Bertrand et al.

Journal of the American Chemical Society, 2004, 126, pp.1328

Article dans une revue hal-00336072v1

Functional aspects of the heme bound hemophore HasA by structural analysis of various crystal forms.

Pascal Arnoux , Richard Haser , Nadia Izadi-Pruneyre , Anne Lecroisey , Mirjam Czjzek

Proteins - Structure, Function and Bioinformatics, 2000, 41 (2), pp.202-10. ⟨10.1002/1097-0134(20001101)41:2<202::AID-PROT50>3.0.CO;2-8⟩

Article dans une revue istex pasteur-00371384v1

The crystal structure of HasA, a hemophore secreted by Serratia marcescens.

Pascal Arnoux , R. Haser , N. Izadi , A. Lecroisey , M. Delepierre et al.

Nature Structural Biology, 1999, 6 (6), pp.516-20. ⟨10.1038/9281⟩

Article dans une revue pasteur-00368051v1

Pseudopaline-mediated zinc uptake by Pseudomonas aeruginosa determines several clinically relevant phenotypes and infection outcomes

L Bosc , Thomas Secher , G Ball , Deborah Le Pennec , M Tribout et al.

2026

Pré-publication, Document de travail hal-05458361v1

Quantitative mapping of methionine sensitivity to oxidation in the copper-bound PcuC chaperone

Lionel Tarrago , Lise Molinelli , Maya Belghazi , Mathilde Tribout , David Lemaire et al.

2026

Pré-publication, Document de travail hal-05454595v1

HssS activation by membrane heme defines a paradigm for 2-component system signaling in<i>Staphylococcus aureus</i>

Vincent Saillant , Léo Morey , Damien Lipuma , Pierre Boëton , Pascal Arnoux et al.

2023

Pré-publication, Document de travail (preprint/prepublication) hal-04184231v1

The Rhodobacter sphaeroides methionine sulfoxide reductase MsrP can reduce R - and S -diastereomers of methionine sulfoxide from a broad-spectrum of protein substrates

Lionel Tarrago , Sandrine Grosse , Marina Siponen , David Lemaire , Béatrice Alonso et al.

2024

Pré-publication, Document de travail hal-04468188v1

In Rhodobacter sphaeroides Respiratory Nitrate Reductase, the Kinetics of Substrate Binding Favors Intramolecular Electron Transfer

Bettina Frangioni , Pascal Arnoux , Monique Sabaty , David Pignol , Patrick Bertrand et al.

European Biological Inorganic Chemistry Conference (EUROBIC 7), Aug 2004, Garmisch-Partenkirchen, Germany. pp.1328 - 1329, ⟨10.1021/ja0384072⟩

Communication dans un congrès istex hal-00338609v1

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