Pascal Bonnet Professeur de Chimie ; Vice-Président de la Recherche de l'Université d'Orléans

Identifiants chercheurs

IdHAL :

pascal-bonnet

ORCID :

0000-0001-6485-138X

IdRef :

069441405

VIAF :

197041422

ISNI :

000000041917668X

ResearcherID :

http://www.researcherid.com/rid/F-7887-2011

Publications

Article dans une revue (44)

New fluoxetine analogues as anti-enterovirus agents targeting 2C protein Safeh Khemiri,Marine Faucher,Stephane Bourg,Sarah Attoumani-Madi,Carole Yaacoubet al. European Journal of Medicinal Chemistry, 2026, pp.118621. ⟨10.1016/j.ejmech.2026.118621⟩ Article dans une revue hal-05481159v1
Prozac 2.0 : from antidepressant to antiviral Marine O Faucher,Safeh Khemiri,Carole Yaacoub,Franck Touret,Sarah Attoumani-Madiet al. Virologie, 2025, 29 (5), pp.380-381. ⟨10.1684/vir.2025.1111⟩ Article dans une revue hal-05379132v1
Spatio-temporal learning from molecular dynamics simulations for protein–ligand binding affinity prediction Pierre-Yves Libouban,Camille Parisel,Maxime Song,Samia Aci-Sèche,Jose C Gómez-Tamayoet al. Bioinformatics, 2025, 41 (8), pp.btaf429. ⟨10.1093/bioinformatics/btaf429⟩ Article dans une revue hal-05346168v1
Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization Anthony Champiré,Rayan Berabez,Abdennour Braka,Aurélie Cosson,Justine Corretet al. European Journal of Medicinal Chemistry, 2024, 271, pp.116391-116391. ⟨10.1016/j.ejmech.2024.116391⟩ Article dans une revue hal-04575964v1
The Identification of New c-FLIP Inhibitors for Restoring Apoptosis in TRAIL-Resistant Cancer Cells Katherine Yaacoub,Rémy Pedeux,Pierre Lafite,Ulrich Jarry,Samia Aci-Sècheet al. Current Issues in Molecular Biology, 2024, 46 (1), pp.710 - 728. ⟨10.3390/cimb46010046⟩ Article dans une revue hal-04439697v1
Highlighting the Major Role of Cyclin C in Cyclin-Dependent Kinase 8 Activity through Molecular Dynamics Simulations Sonia Ziada,Julien Diharce,Dylan Serillon,Pascal Bonnet,Samia Aci-Sèche International Journal of Molecular Sciences, 2024, 25 (10), pp.5411. ⟨10.3390/ijms25105411⟩ Article dans une revue hal-04662241v1
DESIGN, SYNTHESIS AND CHARACTERISATION OF A NOVEL TYPE II B-RAF PARADOX BREAKER INHIBITOR Rohit Arora,Joannes T.M. Linders,Samia Aci-Sèche,Thomas Verheyen,Erika van Heerdeet al. European Journal of Medicinal Chemistry, 2023, 250, pp.115231. ⟨10.1016/j.ejmech.2023.115231⟩ Article dans une revue hal-04037562v1
The Impact of Data on Structure-Based Binding Affinity Predictions Using Deep Neural Networks Pierre-Yves Libouban,Samia Aci-Sèche,Jose Carlos Gómez-Tamayo,Gary Tresadern,Pascal Bonnet International Journal of Molecular Sciences, 2023, 24 (22), pp.16120. ⟨10.3390/ijms242216120⟩ Article dans une revue hal-04662295v1
Design of ERK2 inhibitors for cancer therapy Magdalena Mizerska-Kowalska,Samia Aci-Seche,Stéphane Bourg,Elżbieta Łastawiecka,Pascal Bonnet LE STUDIUM Multidisciplinary Journal, 2023, 7 (16), pp.114-116. ⟨10.34846/le-studium.275.02.fr.09-2023⟩ Article dans une revue hal-05077872v2
A perspective on the sharing of docking data Samia Aci-Sèche,Stéphane Bourg,Pascal Bonnet,Joseph Rebehmed,Alexandre de Brevernet al. Data in Brief, 2023, 49 (22), pp.109386. ⟨10.1016/j.dib.2023.109386⟩ Article dans une revue hal-04251910v1
Design and biological evaluation of substituted 5,7-dihydro-6 H -indolo[2,3- c ]quinolin-6-one as novel selective Haspin inhibitors Sreenivas Avula,Xudan Peng,Xingfen Lang,Micky Tortorella,Béatrice Josselinet al. Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37 (1), pp.1632-1650. ⟨10.1080/14756366.2022.2082419⟩ Article dans une revue hal-03818922v1
Estimation of Drug-Target Residence Time by Targeted Molecular Dynamics Simulations Sonia Ziada,Julien Diharce,Eric Raimbaud,Samia Aci-Sèche,Pierre Ducrotet al. Journal of Chemical Information and Modeling, 2022, ⟨10.1021/acs.jcim.2c00852⟩ Article dans une revue hal-03855904v1
Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-d]Pyrimidine Series as Novel PI3K/mTOR Inhibitors Frédéric Buron,Nuno Rodrigues,Thibault Saurat,Marie-Aude Hiebel,Stéphane Bourget al. Molecules, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩ Article dans une revue hal-03348966v1
Palladium‐Catalyzed Regioselective C−H Arylation of 4‐Azaindazole at C3, C5 and C7 Positions Soukaina Faarasse,Saïd El Kazzouli,Otmane Bourzikat,Stéphane Bourg,Samia Aci-Secheet al. Advanced Synthesis and Catalysis, 2021, 363 (16), pp.3937-3945. ⟨10.1002/adsc.202001421⟩ Article dans une revue hal-03416452v1
Computational Analysis of Crystallization Additives for the Identification of New Allosteric Sites Jade Fogha,Julien Diharce,Alan Obled,Samia Aci-Seche,Pascal Bonnet ACS Omega, 2020, 5 (5), pp.2114-2122. ⟨10.1021/acsomega.9b02697⟩ Article dans une revue hal-02904687v1
Comparative Assessment of Protein Kinase Inhibitors in Public Databases and in PKIDB Colin Bournez,Fabrice Carles,Gautier Peyrat,Samia Aci-Seche,Stéphane Bourget al. Molecules, 2020, 25 (14), pp.3226. ⟨10.3390/molecules25143226⟩ Article dans une revue hal-02904776v1
VSPrep: A KNIME workflow for the preparation of molecular databases for virtual screening Jose-Manuel Gally,Stéphane Bourg,Jade Fogha,Quoc-Tuan Do,Samia Aci-Sècheet al. Current Medicinal Chemistry, 2020, 27 (38), pp.6480-6494. ⟨10.2174/0929867326666190614160451⟩ Article dans une revue hal-02387324v1
Fr-PPIChem: An Academic Compound Library Dedicated to Protein-Protein Interactions Nicolas Bosc,Christophe Muller,Laurent Hoffer,David Lagorce,Stéphane Bourget al. ACS Chemical Biology, 2020, 15 (6), pp.1566-1574. ⟨10.1021/acschembio.0c00179⟩ Article dans une revue hal-02569625v1
Identification of a new series of flavopiridol-like structures as kinase inhibitors with high cytotoxic potency Nada Ibrahim,Pascal Bonnet,Jean-Daniel Brion,Jean-François Peyrat,Jerome Bignonet al. European Journal of Medicinal Chemistry, 2020, 199 (31), pp.112355. ⟨10.1016/j.ejmech.2020.112355⟩ Article dans une revue hal-03036489v1
Cinchona-based zwitterionic stationary phases: Exploring retention and enantioseparation mechanisms in supercritical fluid chromatography with a fragmentation approach Adrien Raimbault,Cam Mai Anh Ma,Martina Ferri,Stefanie Bäurer,Pascal Bonnetet al. Journal of Chromatography A, 2020, 1612, pp.460689. ⟨10.1016/j.chroma.2019.460689⟩ Article dans une revue hal-02904771v1
Design of new disubstituted imidazo[1,2- b ]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation Jonathan Elie,Omid Feizbakhsh,Nathalie Desban,Béatrice Josselin,Blandine Baratteet al. Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35 (1), pp.1840-1853. ⟨10.1080/14756366.2020.1825408⟩ Article dans une revue hal-03004407v1
Hyphenation of ultra-high performance supercritical fluid chromatography with atmospheric pressure chemical ionisation high resolution mass spectrometry: Part 2. Study of chromatographic and mass spectrometry parameters for the analysis of natural non-polar compounds Johanna Duval,Cyril Colas,Pascal Bonnet,Eric Lesellier Journal of Chromatography A, 2019, 1596, pp.199 - 208. ⟨10.1016/j.chroma.2019.03.018⟩ Article dans une revue hal-03484950v1
An original class of small sized molecules as versatile fluorescent probes for cellular imaging Doina Sirbu,Julien Diharce,Ivana Martinić,Nicolas Chopin,Svetlana Eliseevaet al. Chemical Communications, 2019, 55 (54), pp.7776-7779. ⟨10.1039/C9CC03765A⟩ Article dans une revue hal-02373125v1
In silico peptide ligation: Iterative Residue Docking and Linking as a new approach to predict protein-peptide interactions Julien Diharce,Mickaël Cueto,Massimiliano Beltramo,Vincent Aucagne,Pascal Bonnet Molecules, 2019, 24 (7), pp.1-14. ⟨10.3390/molecules24071351⟩ Article dans une revue hal-03525312v1
Residence Time Prediction of Type 1 and 2 Kinase Inhibitors from Unbinding Simulations Abdennour Braka,Norbert Garnier,Pascal Bonnet,Samia Aci-Seche Journal of Chemical Information and Modeling, 2019, 60 (1), pp.342-348. ⟨10.1021/acs.jcim.9b00497⟩ Article dans une revue hal-02494409v1
PKIDB: A Curated, Annotated and Updated Database of Protein Kinase Inhibitors in Clinical Trials Fabrice Carles,Stéphane Bourg,Christophe Meyer,Pascal Bonnet Molecules, 2018, 23 (4), pp.908. ⟨10.3390/molecules23040908⟩ Article dans une revue hal-02904769v1
Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors Bruno Oyallon,Marie Brachet-Botineau,Cédric Logé,Pascal Bonnet,Mohamed Souabet al. European Journal of Medicinal Chemistry, 2018, 154, pp.101-109. ⟨10.1016/j.ejmech.2018.04.056⟩ Article dans une revue hal-03408667v1
Enhanced molecular dynamics methods applied to drug design projects Sonia Ziada,Abdennour Braka,Julien Diharce,Samia Aci-Seche,Pascal Bonnet Methods in Molecular Biology, 2018, 1762, pp.403-426. ⟨10.1007/978-1-4939-7756-7_20⟩ Article dans une revue hal-01966502v1
Synthesis of novel series of 7,7 '-(substituted methylene) bis-imidazo 1,2-b pyrazoles via an acid catalyzed one-pot three-component reaction Mohsine Driowya,Hassan Allouchi,Jose Manuel Gally,Pascal Bonnet,Gérald Guillaumet New Journal of Chemistry, 2018, 42 (8), pp.5728-5741. ⟨10.1039/c7nj05088g⟩ Article dans une revue hal-02620165v1
Development of Kinase Inhibitors via Metal-Catalyzed C–H Arylation of 8-Alkyl-thiazolo[5,4-f]-quinazolin-9-ones Designed by Fragment-Growing Studies Florence Couly,Marine Harari,Carole Dubouilh-Benard,Laëtitia Bailly,Emilie Petitet al. Molecules, 2018, 23 (9), pp.2181. ⟨10.3390/molecules23092181⟩ Article dans une revue hal-02024491v1
PKIDB: A Curated, Annotated and Updated Database of Protein Kinase Inhibitors in Clinical Trials Fabrice Carles,Stéphane Bourg,Christophe Meyer,Pascal Bonnet Molecules, 2018, 23 (4), pp.908. ⟨10.3390/molecules23040908⟩ Article dans une revue hal-04272950v1
Comprehensive Network Map of ADME-Tox Databases Baptiste Canault,Stéphane Bourg,Philippe Vayer,Pascal Bonnet Molecular Informatics, 2017, 36 (10), pp.1700029. ⟨10.1002/minf.201700029⟩ Article dans une revue hal-02904766v1
VSPrep: A General KNIME Workflow for the Preparation of Molecules for Virtual Screening José-Manuel Gally,Stéphane Bourg,Quoc-Tuan Do,Samia Aci-Seche,Pascal Bonnet Molecular Informatics, 2017, 36 (10), pp.1700023. ⟨10.1002/minf.201700023⟩ Article dans une revue hal-02904764v1
30th Franco-Belgian conference of pharmacochemistry Charlotte Bouckaert,Eric Goffin,Sebastien Dilly,Julien Hanson,Lionel Pochetet al. Pharmaceuticals, 2016, 9 (4), pp.73. ⟨10.3390/ph9040073⟩ Article dans une revue hal-02141338v1
Advanced molecular dynamics simulation methods for kinase drug discovery Samia Aci-Seche,Sonia Ziada,Abdennour Braka,Rohit Arora,Pascal Bonnet Future Medicinal Chemistry, 2016, 8 (5), pp.545-566. ⟨10.4155/fmc.16.9⟩ Article dans une revue hal-02494426v1
Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors Aziz Ouach,Rajâa Boulahjar,Christine Vala,Stéphane Bourg,Pascal Bonnetet al. European Journal of Medicinal Chemistry, 2016, 115, pp.311--325. ⟨10.1016/j.ejmech.2016.02.072⟩ Article dans une revue hal-01295635v1
Iron-Catalyzed Trifluoromethylation of Enamide Romain Rey-Rodriguez,Pascal Retailleau,Pascal Bonnet,Isabelle Gillaizeau Chemistry - A European Journal, 2015, 21 (9), pp.3572-3575. ⟨10.1002/chem.201406333⟩ Article dans une revue istex hal-01163306v1
Synthesis of dihydropyrimidine α,γ-diketobutanoic acid derivatives targeting HIV integrase Ozkan Sari,Vincent Roy,Mathieu Métifiot,Christophe Marchand,Yves Pommieret al. European Journal of Medicinal Chemistry, 2015, 104, pp.127-138. ⟨10.1016/j.ejmech.2015.09.015⟩ Article dans une revue hal-02904762v1
Advances in tetrahydropyrido[1,2-a]isoindolone (valmerins) series: Potent glycogen synthase kinase 3 and cyclin dependent kinase 5 inhibitors. Rajâa Boulahjar,Aziz Ouach,Stéphane Bourg,Pascal Bonnet,Olivier Lozachet al. European Journal of Medicinal Chemistry, 2015, 101, pp.274-287. ⟨10.1016/j.ejmech.2015.06.046⟩ Article dans une revue hal-01212495v1
Design, Synthesis, and Biological Activity of Pyridopyrimidine Scaffolds as Novel PI3K/mTOR Dual Inhibitors Thibault Saurat,Frédéric Buron,Nuno Rodrigues,Marie-Ludivine de Tauzia,Lionel Colliandreet al. Journal of Medicinal Chemistry, 2014, 57 (3), pp.613-631. ⟨10.1021/jm401138v⟩ Article dans une revue hal-01180887v1
Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness Pierre-Francois Cartron,Mathilde Cheray,Arulraj Nadaradjane,Pascal Bonnet,Sylvain Routieret al. Epigenomics, 2014, 6 (3), pp.267-275. ⟨10.2217/epi.14.18⟩ Article dans une revue inserm-02478615v1
Synthesis and optimization of an original V-shaped collection of 4-7-disubstituted Pyrido[3,2-d]pyrimidines as CDK5 and DYRK1A inhibitors Oussama Dehbi,Abdellatif Tikad,Stéphane Bourg,Pascal Bonnet,Olivier Lozachet al. European Journal of Medicinal Chemistry, 2014, 80, pp.352-363. ⟨10.1016/j.ejmech.2014.04.055⟩ Article dans une revue istex hal-02904758v1
Two-Step One-Pot Synthesis of Benzoannulated Spiroacetals by Suzuki–Miyaura Coupling/Acid-Catalyzed Spiroacetalization Alexey N. Butkevich,Andrei Corbu,Lieven Meerpoel,Ian Stansfield,Patrick Angibaudet al. Organic Letters, 2012, 14, pp.4998 - 5001. ⟨10.1021/ol302088w⟩ Article dans une revue hal-03102296v1
Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase João Neres,Pascal Bonnet,Philip N Edwards,Pravin L Kotian,Alejandro Buschiazzoet al. Bioorganic and Medicinal Chemistry, 2007, 15 (5), pp.2106-2119. ⟨10.1016/j.bmc.2006.12.024⟩ Article dans une revue istex pasteur-02554109v1

Communication dans un congrès (7)

Synthesis and preclinical validation of LIMKs inhibitors: Promising drugs for osteosarcoma treatment? Rayan Berabez,Anthony Champiré,Margaux Sainjon,Abdennour Braka,Samia Aci-Secheet al. SCT 29th Young Research Fellow Meeting, Jul 2022, Nantes, France Communication dans un congrès hal-04822252v1
Synthesis and preclinical validation of LIMKs inhibitors: Promising drugs for osteosarcoma treatment? Anthony Champiré,Margaux Sainjon,Abdennour Braka,Samia Aci-Seche,Pascal Bonnetet al. XXVII EFMC International Symposium on Medicinal Chemistry, Sep 2022, NICE, France Communication dans un congrès hal-04823073v1
Fragment covalent docking (FCD) approach: An innovative in silico tools for the prediction of peptide-protein interaction Julien Diharce,Mickaël Cueto,Vincent Aucagne,Massimiliano Beltramo,Pascal Bonnet 256th National Meeting and Exposition of the American-Chemical-Society Nanoscience, Nanotechnology and Beyond (ACS), American Chemical Society (ACS). USA., Aug 2018, Boston, United States. pp.2 Communication dans un congrès hal-02734800v1
Développement de petites molécules inhibitrices des LIM kinases, nouvelles cibles thérapeutiques pour lutter contre le cancer, les maladies neurologiques et la neurofibromatose Béatrice Vallée,Karen Plé,A. Cosson,M. Doudeau,F. Godinet al. Journée Fédération CBM-ICOA, Jan 2018, Orléans, France Communication dans un congrès hal-02928530v1
Conception of DYRK1A kinase inhibitors via metal-catalyzed C-H arylation, inspired by fragment-growing studies Florence Couly,Julien Diharce,Pascal Bonnet,Meijer Laurent,Corinne Fruitet al. International Electronic Conference on Medicinal Chemistry (ECMC, 4, 2018), Jean-Jacques Vanden Eynde (coord.), Nov 2018, [online], Belgium. ⟨10.3390/ecmc-4-05580⟩ Communication dans un congrès hal-02383907v1
PrePeP – A Tool for the Identification and Characterization of Pan Assay Interference Compounds Maksim Koptelov,Albrecht Zimmermann,Pascal Bonnet,Ronan Bureau,Bruno Crémilleux 24th ACM SIGKDD International Conference on Knowledge Discovery & Data Mining, Aug 2018, Londres, United Kingdom. pp.462-471, ⟨10.1145/3219819.3219849⟩ Communication dans un congrès hal-01939468v1
Neurofibromatosis type I: from basic to applied research Béatrice Vallée,A. Cosson,M. Doudeau,F Godin,A. Brakaet al. 4th LIA Workshop, Jun 2017, Cracovie, Poland Communication dans un congrès hal-02928517v1

Poster de conférence (6)

ChemBioFrance small molecules for health and research Pascal Bonnet,Florence Mahuteau-Betzer,Mikaël Le Clech,Kiet Tran RICT 2025 - 59th International Conference on Medicinal Chemistry, Jul 2025, Orléans, France Poster de conférence hal-05151514v1
Development of small molecule inhibitors of LIM kinases, new therapeutic targets to treat Neurofibromatosis type I Béatrice Vallée,A. Cosson,M. Doudeau,F. Godin,A. Champiréet al. Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France Poster de conférence hal-02924077v1
LIM Kinases: new anticancer therapeutic targets Béatrice Vallée,A. Cosson,M. Doudeau,F. Godin,Anthony Champiréet al. Breast Cancer Symposium, Jun 2017, Nantes, France Poster de conférence hal-03680148v1
Computational study of ligand-receptor binding process using enhanced molecular dynamics simulations A. Braka,Samia Aci-Seche,S. Bourg,Norbert Garnier,Pascal Bonnet 21st European Symposium on Quantitative Structure-Activity Relationship, Sep 2016, Vérone, Italy Poster de conférence hal-02919149v1
LIM kinases: new therapeutic targets to treat Neurofibromatosis type I Béatrice Vallée,Michel Doudeau,Fabienne Godin,Anthony Champiré,Karen Pléet al. The 7th EMBO meeting, Sep 2016, Mannheim, Germany. Poster de conférence hal-02453490v1
Projet Région LiCorNe: LIMK protein inhibitors, new therapeutic agents for treatment of cognitive disorders associated with type I Neurofibromatosis Béatrice Vallée,Michel Doudeau,F. Godin,H. Cubéros,A. Champiréet al. Journée Fédération PCV FR2708, Jan 2016, Orléans, France Poster de conférence hal-02924056v1

Chapitre d'ouvrage (1)

The vision of ATHENA research-based cooperation by the University of Orléans (UORL) Ioan Todinca,Pascal Bonnet József Györkös; Ron Blonder; Anne Friderike Delouis; Konstantinos Petridis. ATHENA Advanced Technology Higher Education Network Alliance The Vision of ATHENA Research-based Cooperation, 2, University of Maribor, University Press, 2023, 978-961-286-783-6. ⟨10.18690/um.4.2023⟩ Chapitre d'ouvrage hal-05500075v1

Brevet (1)

4-(7H-Pyrrolo[2,3-D]pyrimidin-4-yl)-3,6-dihydropyridine-(2H)-carboxamide derivatives as Limk and/or Rock kinases inhibitors for use in the treatment of cancer Sylvain Routier,Hélène Bénédetti,Béatrice Vallée,Pascal Bonnet,Karen Pléet al. France, Patent n° : WO2021239727 A1. AMV. 2021 Brevet hal-03555349v1