Pascal Rihet

Présentation

Le parcours académique de Pascal Rihet a débuté à l'École Normale Supérieure (ENS) de Saint-Cloud, où il a été élève normalien de 1982 à 1986. Pascal Rihet a obtenu son doctorat en immunologie à l'Université de la Méditerranée pour ses travaux sur le rôle protecteur des IgE dans la schistosomiase. Il a été nommé maître de conférences en immunologie à l'Université de la Méditerranée en 1992. Il a été promu professeur titulaire de génomique à l'université d'Aix-Marseille en 2008. Il a dirigé le master en bio-informatique, biologie structurale et génomique de 2008 à 2017. Il a supervisé la thèse de doctorat de 16 étudiants et a participé à 65 jurys de thèse et HDR. Il a été membre du conseil de l'école doctorale des sciences de la vie et de la santé ED62 de 2007 à 2024. Par ailleurs, il a été directeur adjoint ou directeur du laboratoire TAGC, une unité de recherche labellisée par l’INSERM et Aix-Marseille Université, de 2012 à 2026.

Ses recherches portent sur la génétique et la génomique de maladies multifactorielles, telles que le paludisme, le sepsis, la Covid-19 et le cancer (le projet principal concernant le paludisme). L'objectif global est d'identifier les gènes, les réseaux de gènes et leurs variations impliqués dans le contrôle de l'infection, l'élimination des cellules tumorales et l'apparition de la maladie. Le projet combine une approche de clonage positionnel chez l'homme et la souris, des études transcriptomiques, des analyses bioinformatiques et une validation expérimentale sur des modèles animaux et des modèles cellulaires. Il a i) identifié des signatures transcriptionnelles associées à des phénotypes cliniques, ii) cartographié plusieurs gènes impliqués dans le paludisme et le sepsis chez l'homme ou la souris, et iii) identifié plusieurs variants génétiques régulateurs situés dans des promoteurs, des enhancers ou des silencers, ayant un impact à la fois sur l’expression des gènes et sur les phénotypes cliniques.

Publications

Article dans une revue (79)

A Functional Intronic Variant of LILRB1 Associated with Clinical Malaria in the Senegalese Population Christelle Dieppois,Gaël Chambonnier,Frederic Gallardo,Magali Torres,Alassane Thiamet al. Journal of Infectious Diseases, 2026, Online ahead of print. ⟨10.1093/infdis/jiag007⟩ Article dans une revue hal-05443497v1
Unraveling an enhancer-silencer regulatory element showing epistatic interaction with a variant that escaped genome-wide association studies Mathieu Adjemout,Samia Nisar,Amélie Escandell,Romain Torres,Magali Torreset al. Cell Genomics, 2025, 5 (7), pp.100889. ⟨10.1016/j.xgen.2025.100889⟩ Article dans une revue hal-05173109v1
An Expression Quantitative Trait Locus of Fc Gamma Receptor Genes is Associated with Anti-Malarial IgG Responses and Infection Levels in Burkinabe Families Running Title: Association of rs1771575 with Malaria Christelle Dieppois,Mathieu Adjemout,Jules Cretin,Frederic Gallardo,Magali Torreset al. Journal of Infectious Diseases, In press, 2231 (4), pp.1008-1019. ⟨10.1093/infdis/jiae528⟩ Article dans une revue hal-04750444v1
From Genome-wide Association Studies to Functional Variants: ARL14 Cis - regulatory Variants Are Associated With Severe Malaria Mathieu Adjemout,Frederic Gallardo,Magali Torres,Alassane Thiam,Babacar Mbengueet al. Journal of Infectious Diseases, 2024, pp.jiae159. ⟨10.1093/infdis/jiae159⟩ Article dans une revue hal-04549763v1
The Contribution of Multiplexing Single Cell RNA Sequencing in Acute Myeloid Leukemia Lamia Madaci,Charlyne Gard,Sébastien Nin,Geoffroy Venton,Pascal Rihetet al. Diseases, 2023, 11 (3), pp.96. ⟨10.3390/diseases11030096⟩ Article dans une revue hal-04161267v1
Concurrent PIEZO1 activation and ATP2B4 blockade effectively reduce the risk of cerebral malaria and inhibit in vitro Plasmodium falciparum multiplication in red blood cells Mathieu Adjemout,Bruno Pouvelle,Fatou Thiam,Alassane Thiam,Magali Torreset al. Genes & Diseases, 2023, 10 (6), pp.2210-2214. ⟨10.1016/j.gendis.2023.02.029⟩ Article dans une revue hal-04179608v1
A Non-Coding Fc Gamma Receptor Cis-Regulatory Variant within the 1q23 Gene Cluster Is Associated with Plasmodium falciparum Infection in Children Residing in Burkina Faso Jules Cretin,Mathieu Adjemout,Christelle Dieppois,Frederic Gallardo,Magali Torreset al. International Journal of Molecular Sciences, 2023, 24 (21), pp.15711. ⟨10.3390/ijms242115711⟩ Article dans une revue hal-04268017v1
Single-Cell Transcriptome Analysis of Acute Myeloid Leukemia Cells Using Methanol Fixation and Cryopreservation Lamia Madaci,Charlyne Gard,Sébastien Nin,Alexandre Sarrabay,Céline Baieret al. Diseases, 2023, 12 (1), pp.1. ⟨10.3390/diseases12010001⟩ Article dans une revue hal-04501292v1
ATP2B4 regulatory genetic variants are associated with mild malaria Alassane Thiam,Samia Nisar,Mathieu Adjemout,Frederic Gallardo,Oumar Kaet al. Malaria Journal, 2023, 22 (68), ⟨10.1186/s12936-023-04503-8⟩ Article dans une revue hal-04006760v1
Identification of ATP2B4 Regulatory Element Containing Functional Genetic Variants Associated with Severe Malaria Samia Nisar,Magali Torres,Alassane Thiam,Bruno Pouvelle,Florian Rosieret al. International Journal of Molecular Sciences, 2022, 23 (9), pp.4849. ⟨10.3390/ijms23094849⟩ Article dans une revue hal-03690258v1
Transcriptional Response in a Sepsis Mouse Model Reflects Transcriptional Response in Sepsis Patients Florian Rosier,Nicolas Fernandez Nuñez,Magali Torres,Béatrice B. Loriod,Pascal Rihetet al. International Journal of Molecular Sciences, 2022, 23 (2), pp.821. ⟨10.3390/ijms23020821⟩ Article dans une revue hal-03528060v1
Genetic Predisposition to the Mortality in Septic Shock Patients: From GWAS to the Identification of a Regulatory Variant Modulating the Activity of a CISH Enhancer Florian Rosier,Audrey Brisebarre,Claire Dupuis,Sabrina Baaklini,Denis Puthieret al. International Journal of Molecular Sciences, 2021, 22, ⟨10.3390/ijms22115852⟩ Article dans une revue hal-03245766v1
TAGOOS: genome-wide supervised learning of non-coding loci associated to complex phenotypes Aitor Gonzalez,Marie Artufel,Pascal Rihet Nucleic Acids Research, 2019, ⟨10.1093/nar/gkz320⟩ Article dans une revue hal-02119716v1
Gene expression profiling in blood from cerebral malaria patients and mild malaria patients living in Senegal Alassane Thiam,Michel Sanka,Rokhaya Ndiaye Diallo,Magali Torres,Babacar Mbengueet al. BMC Medical Genomics, 2019, 12 (1), pp.148. ⟨10.1186/s12920-019-0599-z⟩ Article dans une revue hal-02340853v1
Genetic and enzymatic characterization of 3-O-sulfotransferase SNPs associated with Plasmodium falciparum parasitaemia Ngoc Thy Nguyen,Romain R Vivès,Magali Iché-Torres,Vincent Delauzun,Els Saesenet al. Glycobiology, 2018, 28 (7), pp.534-541. ⟨10.1093/glycob/cwy038⟩ Article dans une revue hal-02045171v1
NCR3 polymorphism, haematological parameters, and severe malaria in Senegalese patients Alassane Thiam,Sabrina Baaklini,Babacar Mbengue,Samia Nisar,Maryam Diarraet al. PeerJ, 2018, 6, pp.e6048. ⟨10.7717/peerj.6048⟩ Article dans une revue hal-01947567v1
A transcriptomic signature predicting septic outcome in patients undergoing autologous stem cell transplantation Yasmine Labiad,Geoffroy Venton,Farnault Laure,Céline Baier,Julien Colleet al. Experimental Hematology, 2018, ⟨10.1016/j.exphem.2018.06.001⟩ Article dans une revue hal-01850637v1
Deletion of Nkx2-5 in trabecular myocardium reveals the developmental origins of pathological heterogeneity associated with ventricular non-compaction cardiomyopathy Caroline Choquet,Thi Hong Minh Nguyen,Pierre Sicard,Emeline Buttigieg,Thi Thom Tranet al. PLoS Genetics, 2018, 14 (7), pp.e1007502. ⟨10.1371/journal.pgen.1007502⟩ Article dans une revue hal-01832385v1
Vorinostat and Mithramycin A in combination therapy as an interesting strategy for the treatment of Sézary T lymphoma: a transcriptomic approach R. Ragheb,G. Venton,R. Chelbi,N. Bonnet,T. Le Treutet al. Archives of Dermatological Research, 2017, 309 (8), pp.611-623. ⟨10.1007/s00403-017-1761-0⟩ Article dans une revue hal-01595894v1
Interplay between trauma and Pseudomonas entomophila infection in flies: a central role of the JNK pathway and of CrebA Ramy Ragheb,Alexandre Chuyen,Magali Torres,Arnaud Defaye,Denis Seyreset al. Scientific Reports, 2017, 7 (1), pp.16222. ⟨10.1038/s41598-017-14969-7⟩ Article dans une revue hal-01662954v1
Association of a functional TNF variant with Plasmodium falciparum parasitaemia in a congolese population T. N. Nguyen,S. Baaklini,F. Koukouikila-Koussounda,M. Ndounga,M. Torreset al. Genes and Immunity, 2017, ⟨10.1038/gene.2017.13⟩ Article dans une revue hal-01595896v1
Beyond genome-wide scan: Association of a cis-regulatory NCR3 variant with mild malaria in a population living in the Republic of Congo Sabrina Baaklini,Sarwat Afridi,Thy Ngoc Nguyen,Felix Koukouikila-Koussounda,Mathieu Ndoungaet al. PLoS ONE, 2017, 12 (11), pp.e0187818. ⟨10.1371/journal.pone.0187818⟩ Article dans une revue hal-01633311v1
Natural killer cells in acute myeloid leukemia patients: from phenotype to transcriptomic analysis G. Venton,Y. Labiad,J. Colle,A. Fino,S. Afridiet al. Immunologic Research, 2016, 64 (5-6), pp.1225-1236. ⟨10.1007/s12026-016-8848-0⟩ Article dans une revue hal-01460129v1
Genome-wide significant linkage to IgG subclass responses against Plasmodium falciparum antigens on chromosomes 8p22-p21, 9q34 and 20q13 A. Brisebarre,B. Kumulungui,S. Sawadogo,S. Afridi,F. Fumouxet al. Genes and Immunity, 2015, 16 (3), pp.187-192. ⟨10.1038/gene.2014.66⟩ Article dans une revue hal-01595902v1
Natural killer cells in patients with polycythemia vera Carole Sanchez,Céline Baier,Julien G. Colle,Rabie Chelbi,Pascal Rihetet al. Human Immunology, 2015, 76 (9), pp.644-650. ⟨10.1016/j.humimm.2015.09.010⟩ Article dans une revue hal-01595901v1
Technical data of the transcriptomic analysis performed on tsetse fly symbionts, Sodalis glossinidius and Wigglesworthia glossinidia, harbored, respectively by non-infected, Trypanosoma brucei gambiense infected and self-cured Glossina palpalis gambiensis tsetse flies Anne Geiger,Bernadette Tchicaya,Pascal Rihet Genomics Data, 2015, 4, pp.133-136. ⟨10.1016/j.gdata.2015.04.007⟩ Article dans une revue hal-01595897v1
Serum Pantetheinase/Vanin Levels Regulate Erythrocyte Homeostasis and Severity of Malaria Samuel Rommelaere,Virginie Millet,Pascal Rihet,Scott Atwell,Emmanuèle Helferet al. American Journal of Pathology, 2015, 185 (11), pp.3039-3052. ⟨10.1016/j.ajpath.2015.07.011⟩ Article dans une revue hal-01595898v1
Sperm mRNAs and microRNAs as candidate markers for the impact of toxicants on human spermatogenesis: an application to tobacco smoking Catherine Metzler-Guillemain,Genevieve Victorero,Cyrille Lepoivre,Aurélie Bergon,Miriam Yammineet al. Systems Biology in Reproductive Medicine, 2015, 61 (3), pp.139--149. ⟨10.3109/19396368.2015.1022835⟩ Article dans une revue hal-01445195v1
Inflammation and sepsis as part of hematopoietic stem cell transplantation: a transcriptomic approach Y. Labiad,C. Mercier,I. Vadim,L. Farnault,J. Colleet al. Bone Marrow Transplantation, 2015, 50, pp.S418 Article dans une revue hal-01595899v1
Identification of AREG and PLK1 pathway modulation as a potential key of the response of intracranial 9L tumor to microbeam radiation therapy Audrey Bouchet,Nathalie Sakakini,Michèle El Atifi,Céline Le Clec'H,Elke Braeuer-Krischet al. International Journal of Cancer, 2015, 136 (11), pp.2705-2716. ⟨10.1002/ijc.29318⟩ Article dans une revue hal-01595900v1
The transcriptional signatures of Sodalis glossinidius in the Glossina palpalis gambiensis flies negative for Trypanosoma brucei gambiense contrast with those of this symbiont in tsetse flies positive for the parasite: possible involvement of a Sodalis-hosted prophage in fly Trypanosoma refractoriness? Illiassou Hamidou Soumana,Béatrice B. Loriod,Sophie Ravel,Bernadette Tchicaya,Gustave Simoet al. Infection, Genetics and Evolution, 2014, 24, pp.41-56. ⟨10.1016/j.meegid.2014.03.005⟩ Article dans une revue istex hal-01612139v1
Host susceptibility to malaria in human and mice: compatible approaches to identify potential resistant genes Maria Hernandez-Valladares,Pascal Rihet,Fuad A. Iraqi Physiological Genomics, 2014, 46 (1), pp.1-16. ⟨10.1152/physiolgenomics.00044.2013⟩ Article dans une revue hal-01595905v1
A genome scan for Plasmodium falciparum malaria identifies quantitative trait loci on chromosomes 5q31, 6p21.3, 17p12, and 19p13 Audrey Brisebarre,Brice Kumulungui,Serge Sawadogo,Alexandre Atkinson,Séverine Garnieret al. Malaria Journal, 2014, 13, pp.198. ⟨10.1186/1475-2875-13-198⟩ Article dans une revue hal-01461374v1
Identification of AREG and PLK1 pathway modulation as a potential key of the response of intracranial 9L tumor to microbeam radiation therapy Audrey Bouchet,Nathalie Sakakini,Michèle El Atifi,Céline Le Clec'H,Elke Bräuer-Krischet al. International Journal of Cancer, 2014, 136 (11), pp.2705-2716. ⟨10.1002/ijc.29318⟩ Article dans une revue hal-05142300v1
Approaches combining mice and Drosophila melanogaster models to decipher human sepsis R Ramy,S Garnier,Lydie Pradel,Laurence Röder,Béatrice B. Loriodet al. Critical Care, 2014, 18 (S2), ⟨10.1186/cc14070⟩ Article dans une revue hal-01619083v1
Identification of overexpressed genes in Sodalis glossinidius inhabiting trypanosome-infected self-cured tsetse flies Illiassou Hamidou Soumana,Bernadette Tchicaya,Béatrice B. Loriod,Pascal Rihet,Anne Geiger Frontiers in Microbiology, 2014, 5, pp.255. ⟨10.3389/fmicb.2014.00255⟩ Article dans une revue hal-01612141v1
Striatal molecular signature of subchronic subthalamic nucleus high frequency stimulation in parkinsonian rat Sylviane Lortet,Emilie Lacombe,Nicolas Boulanger,Pascal Rihet,Catherine Nguyenet al. PLoS ONE, 2013, 8 (4), pp.e60447. ⟨10.1371/journal.pone.0060447⟩ Article dans une revue hal-00862146v1
Natural killer cells modulation in hematological malignancies Céline T Baier,Aurore T Fino,Carole T Sanchez,Laure Farnault,Pascal Rihetet al. Frontiers in Immunology, 2013, NK and lymphoid cell biology (4), pp.459. ⟨10.3389/fimmu.2013.00459⟩ Article dans une revue hal-01455668v1
Early Gene Expression Analysis in 9L Orthotopic Tumor-Bearing Rats Identifies Immune Modulation in Molecular Response to Synchrotron Microbeam Radiation Therapy Audrey Bouchet,Nathalie Sakakini,Michèle El Atifi,Céline Le Clec'H,Elke Braueret al. PLoS ONE, 2013, 8 (12), pp.e81874. ⟨10.1371/journal.pone.0081874⟩ Article dans une revue hal-05142307v1
Early gene expression analysis in 9L orthotopic tumor-bearing rats identifies immune modulation in molecular response to synchrotron microbeam radiation therapy. Audrey Bouchet,Nathalie Sakakini,Michèle El Atifi,Céline Le Clec'H,Elke Braueret al. PLoS ONE, 2013, 8 (12), pp.e81874. ⟨10.1371/journal.pone.0081874⟩ Article dans une revue inserm-00955553v1
Functional Polymorphisms in the Regulatory Regions of the VNN1 Gene Are Associated with Susceptibility to Inflammatory Bowel Diseases Thomas Gensollen,Christophe Bourges,Pascal Rihet,Agathe Rostan,Virginie Milletet al. Inflammatory Bowel Diseases, 2013, 19 (11), pp.2315-2325. ⟨10.1097/MIB.0b013e3182a32b03⟩ Article dans une revue hal-01595906v1
IL-12Rβ2 is essential for the development of experimental cerebral malaria. Mathilde Fauconnier,Jennifer Palomo,Marie-Laure Bourigault,Sandra Meme,Frédéric Szeremetaet al. Journal of Immunology, 2012, 188 (4), pp.1905-14. ⟨10.4049/jimmunol.1101978⟩ Article dans une revue hal-00721858v1
Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology Denise Lemaire,Theoliz Barbosa,Pascal Rihet Brazilian Journal of Medical and Biological Research, 2012, 45 (5), pp.376-385. ⟨10.1590/S0100-879X2011007500142⟩ Article dans une revue hal-01455691v1
Genetic variations in genes involved in heparan sulphate biosynthesis are associated with Plasmodium falciparum parasitaemia: a familial study in Burkina Faso. Alexandre Atkinson,Séverine Garnier,Sarwat Afridi,Francis Fumoux,Pascal Rihet Malaria Journal, 2012, 11 (1), pp.108. ⟨10.1186/1475-2875-11-108⟩ Article dans une revue inserm-00703058v1
Malaria resistance genes are associated with the levels of IgG subclasses directed against Plasmodium falciparum blood-stage antigens in Burkina Faso. Sarwat Afridi,Alexandre Atkinson,Séverine Garnier,Francis Fumoux,Pascal Rihet Malaria Journal, 2012, 11 (1), pp.308. ⟨10.1186/1475-2875-11-308⟩ Article dans une revue inserm-00780329v1
Platelets Alter Gene Expression Profile in Human Brain Endothelial Cells in an In Vitro Model of Cerebral Malaria Mathieu Barbier,Dorothée Faille,Béatrice B. Loriod,Julien Textoris,Claire Camuset al. PLoS ONE, 2011, 6 (5), pp.e19651. ⟨10.1371/journal.pone.0019651⟩ Article dans une revue hal-01743259v1
Evidence for epistasis between hemoglobin C and immune genes in human P. falciparum malaria: a family study in Burkina Faso A. Atkinson,M. Barbier,S. Afridi,F. Fumoux,P. Rihet Genes and Immunity, 2011, 12 (6), pp.481-489. ⟨10.1038/gene.2011.19⟩ Article dans une revue hal-01595908v1
Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. Nicolas F Delahaye,Sylvie Rusakiewicz,Isabelle Martins,Cédric Ménard,Stephan Rouxet al. Nature Medicine, 2011, 17 (6), pp.700-7. ⟨10.1038/nm.2366⟩ Article dans une revue hal-00665651v1
Genome-Wide Expression Profiling Deciphers Host Responses Altered during Dengue Shock Syndrome and Reveals the Role of Innate Immunity in Severe Dengue Stephanie Devignot,Cedric Sapet,Veasna Duong,Aurélie Bergon,Pascal Rihetet al. PLoS ONE, 2010, 5 (7), ⟨10.1371/journal.pone.0011671⟩ Article dans une revue hal-01595911v1
Peripheral T-cell lymphoma gene expression profiling and potential therapeutic exploitations Régis Costello,Carole Sanchez,Therese Le Treut,Pascal Rihet,Jean Imbertet al. British Journal of Haematology, 2010, 150 (1), pp.21-27 Article dans une revue hal-01595909v1
Family-based association of a low producing lymphotoxin-alpha allele with reduced Plasmodium falciparum parasitemia Mathieu Barbier,Nicolas F. Delahaye,Francis Fumoux,Pascal Rihet Microbes and Infection, 2008, 10 (6), pp.673-679 Article dans une revue hal-01595913v1
IL12B polymorphisms are linked but not associated with Plasmodium falciparum parasitemia: a familial study in Burkina Faso M. Barbier,A. Atkinson,F. Fumoux,P. Rihet Genes and Immunity, 2008, 9 (5), pp.405-411 Article dans une revue hal-01595912v1
Association analyses of NCR3 polymorphisms with P-falciparum mild malaria Nicolas F. Delahaye,Mathieu Barbier,Francis Fumoux,Pascal Rihet Microbes and Infection, 2007, 9 (2), pp.160-166. ⟨10.1016/j.micinf.2006.11.002⟩ Article dans une revue istex hal-01595914v1
Gene expression analysis reveals early changes in several molecular pathways in cerebral malaria-susceptible mice versus cerebral malaria-resistant mice N. F. Delahaye,N. Coltel,Denis Puthier,M. Barbier,P. Benechet al. BMC Genomics, 2007, 8, pp.452 Article dans une revue hal-01595820v1
Gene-expression profiling discriminates between cerebral malaria (CM)-susceptible mice and CM-resistant mice. N.F. Delahaye,N. Coltel,D. Puthier,Laurence Flori,R. Houlgatteet al. Journal of Infectious Diseases, 2006, 193, pp.312-321 Article dans une revue hal-02654443v1
Gene-expression profiling discriminates between cerebral malaria (CM)-susceptible mice and CM-resistant mice. Nicolas F. Delahaye,Nicolas Coltel,Denis Puthier,Laurence Flori,Rémi Houlgatteet al. Journal of Infectious Diseases, 2006, 193 (2), pp.312-21. ⟨10.1086/498579⟩ Article dans une revue inserm-00276272v1
Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ M. Hernandez-Valladares,J. Naessens,A. J. Musoke,K. Sekikawa,P. Rihetet al. Experimental Parasitology, 2006, 114 (4), pp.271-278 Article dans une revue hal-01595915v1
TNF as a malaria candidate gene: polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso. Laurence Flori,N.F. Delahaye,F.A. Iraqi,M. Hernandez-Valladares,F. Fumouxet al. Genes and Immunity, 2005, 6, pp.472-480 Article dans une revue hal-02680051v1
TNF as a malaria candidate gene: polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso L Flori,Nf Delahaye,Fa Iraqi,M Hernandez-Valladares,F Fumouxet al. Genes and Immunity, 2005, 6 (6), pp.472-480 Article dans une revue hal-01595917v1
Influence of carriage of hemoglobin AS and the Fc gamma receptor IIa-R-131 allele on levels of immunoglobulin G2 antibodies to Plasmodium falciparum merozoite antigens in Gabonese children F Ntoumi,L Flori,Pi Mayengue,Dwm Maya,S Issifouet al. Journal of Infectious Diseases, 2005, 192 (11), pp.1975-1980. ⟨10.1086/497611⟩ Article dans une revue hal-01595918v1
Influence of carriage of hemoglobin AS and the Fcg receptor IIa-R131 allele on levels of immunoglobulin G2 antibodies to plasmodium falciparum merozoite antigens in Gabonese children. F. Ntoumi,Laurence Flori,P.I. Mayengue,D.W. Matondo Maya,S. Issifouet al. Journal of Infectious Diseases, 2005, 192, pp.1975-1980 Article dans une revue hal-02676176v1
Hemoglobin C is associated with reduced Plasmodium falciparum parasitemia and low risk of mild malaria attack Pascal Rihet,L Flori,F Tall,As Traore,F Fumoux Human Molecular Genetics, 2004, 13 (1), pp.1-6 Article dans une revue hal-01595920v1
Comparison of pathology in susceptible A/J and resistant C57BL/6J mice after infection with different sub-strains of Plasmodium chabaudi M Hernandez-Valladares,J Naessens,S Nagda,Aj Musoke,Pascal Rihetet al. Experimental Parasitology, 2004, 108 (3-4), pp.134-141 Article dans une revue hal-01595922v1
Mapping of a new quantitative trait locus for resistance to malaria in mice by a comparative mapping approach with human Chromosome 5q31-q33 M Hernandez-Valladares,Pascal Rihet,Ok Ole-Moiyoi,Fa Iraqi Immunogenetics, 2004, 56 (2), pp.115-117 Article dans une revue hal-01595919v1
Confirmation and dissection of QTL controlling resistance to malaria in mice M Hernandez-Valladares,J Naessens,Jp Gibson,Aj Musoke,S Nagdaet al. Mammalian Genome, 2004, 15 (5), pp.390-398 Article dans une revue hal-01595921v1
Linkage and association between Plasmodium falciparum blood infection levels and chromosome 5q31-q33 L Flori,B Kumulungui,C Aucan,C Esnault,As Traoreet al. Genes and Immunity, 2003, 4 (4), pp.265-268 Article dans une revue hal-01595924v1
Linkage of mild malaria to the major histocompatibility complex in families living in Burkina Faso L Flori,S Sawadogo,C Esnault,Nf Delahaye,F Fumouxet al. Human Molecular Genetics, 2003, 12 (4), pp.375-378 Article dans une revue hal-01595923v1
Familial correlation of immunoglobulin g subclass responses to Plasmodium falciparum antigens in Burkina Faso C Aucan,Y Traore,F Fumoux,Pascal Rihet Infection and Immunity, 2001, 69 (2), pp.996-1001 Article dans une revue hal-01595925v1
Modification of P-selectin glycoprotein ligand-1 with a natural killer cell-restricted sulfated lactosamine creates an alternate ligand for L-selectin P André,O Spertini,S Guia,Pascal Rihet,Francoise Dignat-Georgeet al. Proceedings of the National Academy of Sciences of the United States of America, 2000, 97 (7), pp.3400-3405. ⟨10.1073/pnas.97.7.340⟩ Article dans une revue hal-01595927v1
High immunoglobulin G2 (IgG2) and low IgG4 levels are associated with human resistance to Plasmodium falciparum malaria C Aucan,Y Traore,F Tall,B Nacro,T Traore-Lerouxet al. Infection and Immunity, 2000, 68 (3), pp.1252-1258 Article dans une revue hal-01595926v1
[Analysis of the genetic factors controlling malarial infection in man]. Y Traore,Pascal Rihet,Thérèse Traore-Leroux,C Aucan,P Gazinet al. Sante (Montrouge, France), 1999, 9 (1), pp.53-9 Article dans une revue hal-01595928v1
Genetic dissection of Plasmodium falciparum blood infection levels and other complex traits related to human malaria infection. Pascal Rihet,Y Traore,C Aucan,T Traore-Leroux,B Kumulunguiet al. Parassitologia, 1999, 41 (1-3), pp.83-7 Article dans une revue hal-01595929v1
Human malaria: Segregation analysis of blood infection levels in a suburban area and a rural area in Burkina Faso Pascal Rihet,L Abel,Y Traore,C Aucan,F Fumoux Genetic Epidemiology, 1998, 15 (5), pp.435-450 Article dans une revue hal-01595932v1
Malaria in humans: Plasmodium falciparum blood infection levels are linked to chromosome 5q31-q33 Pascal Rihet,Y Traore,L Abel,C Aucan,T Traore-Lerouxet al. American Journal of Human Genetics, 1998, 63 (2), pp.498-505 Article dans une revue hal-01595931v1
RESISTANCE TO SCHISTOSOMA-MANSONI IN HUMANS - INFLUENCE OF THE IGE/IGG4 BALANCE AND IGG2 IN IMMUNITY TO REINFECTION AFTER CHEMOTHERAPY Ce Demeure,Pascal Rihet,L Abel,M Ouattara,A Bourgoiset al. Journal of Infectious Diseases, 1993, 168 (4), pp.1000-1008 Article dans une revue hal-01595933v1
FACTORS CONTROLLING RESISTANCE TO SCHISTOSOMIASIS IN ENDEMIC AREA A Dessein,Pascal Rihet,C Demeure,P Couissinier,O Bacellaret al. Médecine/Sciences, 1992, 8 (2), pp.108-118 Article dans une revue hal-01595938v1
STRONG SERUM INHIBITION OF SPECIFIC IGE CORRELATED TO COMPETING IGG4, REVEALED BY A NEW METHODOLOGY IN SUBJECTS FROM A SCHISTOSOMA-MANSONI ENDEMIC AREA Pascal Rihet,Ce Demeure,Aj Dessein,A Bourgois European Journal of Immunology, 1992, 22 (8), pp.2063-2070 Article dans une revue hal-01595934v1
ENVIRONMENTAL, GENETIC AND IMMUNOLOGICAL FACTORS IN HUMAN RESISTANCE TO SCHISTOSOMA-MANSONI A Prata,Aj Dessein,P Couissinier,C Demeure,Pascal Rihetet al. Immunological Investigations, 1992, 21 (5), pp.423-453 Article dans une revue hal-01595935v1
EVIDENCE FOR AN ASSOCIATION BETWEEN HUMAN RESISTANCE TO SCHISTOSOMA-MANSONI AND HIGH ANTI-LARVAL IGE LEVELS Pascal Rihet,Ce Demeure,A Bourgois,A Prata,Aj Dessein European Journal of Immunology, 1991, 21 (11), pp.2679-2686 Article dans une revue hal-01595940v1

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122 - Temporal deletions of Nkx2-5 induce hypertrabeculation and progressive conduction defects and heart failure M. Nguyen,C. Choquet,Pierre Sicard,F. Kober,I. Varletet al. Printemps de la Cardiologie : Recherche Fondamentale et Clinique, Apr 2017, Nantes, France. pp.208, ⟨10.1016/S1878-6480(17)30515-3⟩ Communication dans un congrès hal-01784720v1

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IMMUNOLOGICAL MECHANISMS OF HUMAN RESISTANCE TO SCHISTOSOME INFECTION - THE PROTECTIVE EFFECT OF IMMUNOGLOBULIN-E IS BALANCED BY A BLOCKING ACTION OF IMMUNOGLOBULIN-G4 Pascal Rihet,C. E. Demeure,M. Ouattara,A. Bourgois,D. Carvalhoet al. Godard, P. and Bousquet, J. and Michel, F. B. pp.83-91, 1992, Advances in Allergology and Clinical Immunology Ouvrages hal-01595937v1
SCHISTOSOMA-MANSONI P-37 ANTIGEN - IDENTIFICATION BY ANTIBODIES FROM RESISTANT SUBJECTS AND MOLECULAR-CLONING V. Goudotcrozel,Pascal Rihet,C. Demeure,P. Couissinier,A. Prataet al. Agabian, N. and Cerami, A. 130, pp.391-400, 1990, Parasites: Molecular Biology, Drug and Vaccine Design Ouvrages hal-01595941v1

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Identification and Functional Characterization of Regulatory Variants in DPP9 Associated with COVID-19 Severity Gaelle Farah,Magali Torres,Leo Henches,Hugues Aschard,Jade Ghosnet al. 2026 Pré-publication, Document de travail hal-04891442v1