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Pascale Chavatte-Palmer

Pascale Chavatte-Palmer, INRAE Director of the BREED Research unit, University Paris-Saclay, INRAE, University Versailles Saint-Quentin, Ecole nationale Vétérinaire d'Alfort France
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Présentation

**Directrice de l'unité Mixte de Recherches Biologie de la Reproduction, Environnement, Epigénétique et Développement** Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France Ecole Nationale Vétérinaire d’Alfort, BREED, 94700, Maisons-Alfort, France Initially trained as a veterinarian, I specialized in animal, and particularly equine reproduction with a focus on pregnancy and neonatology through my internship, residency and PhD, post-doctoral fellowship and initial position. After my recruitment at AgroParisTech and subsequently INRAE in France, I have been more widely focusing on feto-placental development and the developmental origins of health and disease (DOHaD), with a dual purpose in agriculture and as biomedical models. The aim of my research is to understand the role of the placenta in the programming of long term post-natal health, in the context of the developmental origins of health and diseases. First as a veterinarian and subsequently to be able to perform longitudinal studies in research animals, I have also been developing in vivo imaging technologies such as ultrasound and Doppler to assess placental feto-placental development and placental perfusion. After having led a research group at the National Institute of Agronomical Research (now INRAE), with a mean of 12 permanent staff for the past 14 years, I have recently taken the lead of the new Biology of Reproduction, Environment, Epigenetics and Development (BREED) research unit (90 permanent staff), focusing on the development of the mammalian embryo from the formation of the egg cell to birth and development to adulthood. Projects range from fundamental studies on the functioning of the genome during embryo and fetal growth to applied research on the effects of the environment at large on development in the agronomic, veterinary and biomedical fields. The scientific objective is to understand and control the mechanisms of epigenetic programming during prenatal life, leading to the birth of a healthy, fertile and robust individual, able to adapt to changes in his environment. Meanwhile, I pursue my own research programs on effects of maternal and post-natal breeding conditions, including nutrition, on metabolic and osteoarticular outcomes in the foal. I have served as PI or co-PIU to several national and European research projects (see section D).

Publications

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Effets d’un régime maternel hypergras sur le transcriptome ovocytaire et embryonnaire

Sophie Calderari , Catherine Archilla , Luc Jouneau , Nathalie Daniel , Nathalie N. Peynot
Société Francophone du Diabète, May 2022, Nice, France
Communication dans un congrès hal-03808248v1

Impact d’un environnement (pré)-diabétique sur le développement embryonnaire précoce

Sophie Calderari , Catherine Archilla , Luc Jouneau , Nathalie Daniel , Nathalie N. Peynot
SF-DOHAD, Nov 2021, Jouy-en-Josas, France
Communication dans un congrès hal-03808220v1
Image document

Détermination de la fenêtre de vulnérabilité à une surnutrition lipidique maternelle pour le développement foeto-placentaire: période pré-conceptionnelle et/ou période gestationnelle?

Delphine Rousseau-Ralliard , Marie Sylvie Lallemand , Marie-Christine Aubrière , Michèle Dahirel , Nathalie Daniel
4. Congrès de la SF-Dohad, Société Francophone-DOHaD. FRA., Nov 2018, Grenoble, France. pp.120
Communication dans un congrès hal-02734768v1

Reproductive effects of gestational exposure to diesel exhaust in a rabbit model

Sarah Valentino , Véronique Duranthon , Anne Couturier-Tarrade , Delphine Rousseau-Ralliard , Eve Mourier Mourier
18. International Congress on Animal Reproduction (ICAR), International Organisation on Animal Reproduction. FRA., Jun 2016, Tours, France. 676 p
Communication dans un congrès hal-02740895v1

Reproductive effects of gestational exposure to diesel exhaust in a rabbit model

Sarah Valentino , Anne Couturier-Tarrade , Delphine Rousseau-Ralliard , Eve Mourier , Christophe Richard
3. congrès de la SF-DOHaD, Société Francophone pour la Recherche et l'Education sur les Origines Développementales, Environnementales et Epigénétiques de la Santé et des Maladies (SF-DOHAD). FRA., Dec 2016, Paris, France. 84 p
Communication dans un congrès hal-02743432v1

Maternal exposure to diesel engine exhaust during pregnancy affects early embryo development in a rabbit model

Sarah Valentino , Michèle Dahirel , Eve Mourier Mourier , Catherine Archilla , Christophe Richard
41. Annual Conference of IETS, International Embryo Transfer Society (IETS). USA., Jan 2015, Versailles, France. ⟨10.1071/RDv27n1Ab120⟩
Communication dans un congrès hal-02741151v1

A short periconceptional maternal hyperglycemia is sufficient to disrupt the feto-placental phenotype in a rabbit model

Delphine Rousseau-Ralliard , Anne Couturier-Tarrade , R. Thieme , Roselyne Brat , Marie-Christine Aubrière
41. Annual Conference of IETS, International Embryo Transfer Society (IETS). USA., Jan 2015, Versailles, France. ⟨10.1071/RDv27n1Ab119⟩
Communication dans un congrès hal-02741096v1

A short periconceptional maternal hyperglycemia is sufficient to disrupt the feto-placental phenotype in a rabbit model

Delphine Rousseau-Ralliard , Anne Couturier-Tarrade , René Thieme , Roselyne Brat , Marie-Christine Aubrière
2. Colloque de la SF-DOHaD, Origine Développementale de la santé et des maladies et épigénétique, Société Francophone pour la Recherche et l'Education sur les Origines Développementales, Environnementales et Epigénétiques de la Santé et des Maladies (SF-DOHAD). FRA., Nov 2014, Nantes, France. 57 p
Communication dans un congrès hal-02741228v1
Image document

A short periconceptional exposure to maternal type-1 diabetes is sufficient to disrupt the feto-placental phenotype in a rabbit model

Delphine Rousseau-Ralliard , Anne Couturier-Tarrade , René Thieme , Roselyne Brat , Audrey Rolland
Journée Aviesan, Jun 2019, Paris, France. , 2019, ITMO " Translational research on diabetic cardiomyopathy"
Poster de conférence hal-02733977v1
Image document

A new culture model of rabbit trophoblastic cells to explore cell function and transplacental transfers

Guenhaël Sanz , Nathalie Daniel , Vincent Brochard , Marie-Christine Aubrière , Martine Letheule
Annual Meeting 2018 CellFit, Oct 2018, Hvar Island, Croatia. School of Medicine University of Zagreb, Editors Tiziana Brevini, Alireza Fazeli, Ana Katusic, Ana Vidos, Georgia May, pp.109, 2018, Proceedings of CellFit Meeting 2018 « in vitro 3-D Total Cell Guidance and fitness »
Poster de conférence hal-02738050v1

A new culture model of rabbit trophoblastic cells to explore cell function and transplacental transfers

Guenhaël Sanz , Nathalie Daniel , Vincent Brochard , Marie-Christine Aubrière , Martine Letheule
Regenerative medicine: organoids and model species, Oct 2018, Paris, France. , 2018
Poster de conférence hal-02788443v1
Image document

A short periconceptional exposure to maternal type-1 diabetes is sufficient to disrupt the feto-placentalphenotypein a rabbit model

Delphine Rousseau-Ralliard , Anne Couturier-Tarrade , René Thieme , Roselyne Brat , Audrey Rolland
IFPA 2018, Sep 2018, Tokyo, Japan. , Placenta, 9, pp.93, 2018, Abstracts for the forthcoming International Federation of Placenta Associations Meeting, Tokyo, Japan
Poster de conférence hal-02734076v1
Image document

Détermination de la plus critique fenêtre d'exposition d'une surnutrition lipidique maternelle pour le développement foeto-placentaire: entre la période préconceptionnelle et la période gestationnelle

Delphine Rousseau-Ralliard , Marie-Christine Aubrière , Marie Sylvie Lallemand , Michèle Dahirel , Nathalie Daniel
JFN 2017, Journées Francophones de Nutrition, Dec 2017, Nantes, France. , pp.460, 2017, Livre des résumés Journées Francophones de Nutrition
Poster de conférence hal-02735162v1

High fat maternal diet impacts the nutrient sensing signaling network in rabbit blastocyst

Sophie Calderari , Catherine Archilla , Luc Jouneau , Nathalie N. Peynot , Nathalie N. Daniel
Epiconcept Conference 2016, Sep 2016, Giardini Naxos, Italy. COST Office, 84 p., 2016, Epigenetics and Periconception Environment
Poster de conférence hal-02741142v1

High fat maternal diet impacts the nutrient sensing signaling network in rabbit blastocyst

Sophie Calderari , Catherine Archilla , Luc Jouneau , Nathalie Peynot , Nathalie Daniel
3. congrès de la SF-DOHaD, Dec 2016, Paris, France. , 84 p., 2016, 3ème congrès de la SF-DOHaD
Poster de conférence hal-02741274v1

Reproductive effects of gestational exposure to diesel exhaust in a rabbit model

Sarah Valentino , Véronique Duranthon , Anne Couturier-Tarrade , Delphine Rousseau-Ralliard , Eve Mourier
XIV. International Congress of Toxicology, Oct 2016, Merida, Mexico. Elsevier Ireland Ltd, Toxicology Letters, 259, pp.269, 2016, Toxicology Letters. ⟨10.1016/j.toxlet.2016.07.100⟩
Poster de conférence hal-01533918v1