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Pascale Chavatte-Palmer

Pascale Chavatte-Palmer, INRAE Director of the BREED Research unit, University Paris-Saclay, INRAE, University Versailles Saint-Quentin, Ecole nationale Vétérinaire d'Alfort France
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Présentation

**Directrice de l'unité Mixte de Recherches Biologie de la Reproduction, Environnement, Epigénétique et Développement** Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France Ecole Nationale Vétérinaire d’Alfort, BREED, 94700, Maisons-Alfort, France Initially trained as a veterinarian, I specialized in animal, and particularly equine reproduction with a focus on pregnancy and neonatology through my internship, residency and PhD, post-doctoral fellowship and initial position. After my recruitment at AgroParisTech and subsequently INRAE in France, I have been more widely focusing on feto-placental development and the developmental origins of health and disease (DOHaD), with a dual purpose in agriculture and as biomedical models. The aim of my research is to understand the role of the placenta in the programming of long term post-natal health, in the context of the developmental origins of health and diseases. First as a veterinarian and subsequently to be able to perform longitudinal studies in research animals, I have also been developing in vivo imaging technologies such as ultrasound and Doppler to assess placental feto-placental development and placental perfusion. After having led a research group at the National Institute of Agronomical Research (now INRAE), with a mean of 12 permanent staff for the past 14 years, I have recently taken the lead of the new Biology of Reproduction, Environment, Epigenetics and Development (BREED) research unit (90 permanent staff), focusing on the development of the mammalian embryo from the formation of the egg cell to birth and development to adulthood. Projects range from fundamental studies on the functioning of the genome during embryo and fetal growth to applied research on the effects of the environment at large on development in the agronomic, veterinary and biomedical fields. The scientific objective is to understand and control the mechanisms of epigenetic programming during prenatal life, leading to the birth of a healthy, fertile and robust individual, able to adapt to changes in his environment. Meanwhile, I pursue my own research programs on effects of maternal and post-natal breeding conditions, including nutrition, on metabolic and osteoarticular outcomes in the foal. I have served as PI or co-PIU to several national and European research projects (see section D).

Publications

"audrey-prezelin"

Effect of Maternal Exposure to a Cocktail of Food Contaminants on Feto-Placental Development and Growth in a Rabbit Model

Jeanne Bozec , Delphine Rousseau-Ralliard , Christophe Richard , Valerie Gelin , Audrey Prézelin
European Placenta Group, Nov 2022, Jouy-en-Josas, France
Communication dans un congrès hal-03883821v1
Image document

Nursing in the periconceptional period alters placental gene expression and subsequent foal growth

Emilie Derisoud , Orianne Valais , Luc Jouneau , Alexia Durand , Michèle Dahirel
18th European Placenta Group IFPA meeting, European Placenta Group, Nov 2022, Jouy en Josas, France
Communication dans un congrès hal-03903205v1

Exposition maternelle aux nanoparticules métalliques (Au-pvp, Ag, CeO2) par instillation: effets sur la fonction placentaire et le phénotype fœtal.

Anne Couturier-Tarrade , Delphine Rousseau-Ralliard , Audrey Geeverding , Luc Jouneau , Valerie Gelin
SF-DOHaD, Nov 2021, Jouy-en-Josas, France
Communication dans un congrès hal-03483311v1
Image document

Effets de la supplémentation alimentaire en arginine chez les juments gravides sur le métabolisme maternal, la fonction placentaire et le poids de naissance des poulains

Pascale Chavatte-Palmer , Morgane Robles , Emilie Derisoud , Audrey Geeverding , Josiane Aioun
4. Congrès de la SF-Dohad, Société Francophone de la Dohad., Nov 2018, Grenoble, France. pp.120
Communication dans un congrès hal-02735937v1

Conséquences tardives de perturbations épigénétiques précoces : exemple des clones bovins

Hélène Kiefer , Luc Jouneau , Evelyne Campion , Delphine Rousseau-Ralliard , Thibaut Larcher
1. Journée de Séminaires du Département Phase sur l'Epigénétique EpiPhase, Institut National de Recherche Agronomique (INRA). UAR Département Physiologie Animale et Systèmes d'Elevage (0558)., Jun 2015, Paris, France
Communication dans un congrès hal-01197642v1

An aberrant age of liver DNA methylation is associated with cloning-induced pathologies

Hélène Kiefer , Luc Jouneau , Evelyne E. Campion , Delphine Rousseau-Ralliard , Thibaut T. Larcher
Conférence Jacques Monod, DNA methylation and demethylation, Centre National de la Recherche Scientifique (CNRS). FRA., Nov 2015, Roscoff, France
Communication dans un congrès hal-02797595v1

Placental gene expression reveals reduced angiogenesis in primiparous mares

Emilie Derisoud , Orianne Valais , Luc Jouneau , Alexia Durand , Audrey Prézelin
XIIth International Symposium on Equine Reproduction (ISER), Jul 2023, Fos do Iguaçu, Brazil. Journal of equine veterinary science, 125, pp.104763, 2023, ⟨10.1016/j.jevs.2023.104763⟩
Poster de conférence hal-04147559v1

Conséquences d’une exposition maternelle à un cocktail de contaminants alimentaires sur le développement et la croissance foeto-placentaire chez le lapin

Jeanne Bozec , Delphine Rousseau-Ralliard , Christophe Richard , Valerie Gelin , Audrey Prézelin
Journées francophones de nutrition, Nov 2022, Toulouse, France
Poster de conférence hal-03883817v1
Image document

NURSING IN THE PERICONCEPTIONAL PERIOD ALTERS PLACENTAL GENE EXPRESSION AND SUBSEQUENT FOAL GROWTH

Emilie Derisoud , Juliette Auclair-Ronzaud , Orianne Valais , Luc Jouneau , Alexia Durand
DOHAD World Congress 2022, Aug 2022, Vancouver, Canada.
Poster de conférence hal-03793660v1
Image document

Maternal age alters gene expression in blastocyst trophoblast and term placenta as well as term placental structure

Emilie Derisoud , Sarah Gastaldo , Orianne Valais , Luc Jouneau , Cedric Dubois
IFPA meeting 2021, Aug 2021, online, Netherlands.
Poster de conférence hal-03348714v1

Effets de la supplémentation alimentaire en arginine chez les juments gravides sur le métabolisme maternel, la fonction placentaire et le poids de naissance des poulains.

Pascale Chavatte-Palmer , Morgane Robles , Emilie Derisoud , Audrey Geeverding , Josiane Aioun
7. Rencontre du Groupe de la Francophonie Placentaire 2019, Mar 2019, Paris, France. 36p, 2019
Poster de conférence hal-02264920v1

230 Slight alterations of trophoblast gene expression are related to the term placenta morphology and gene expression in horses

Emilie Derisoud , O. Valais , Luc Jouneau , C. Dubois , A. Durand
International Embryo Technology Society (IETS), Reproduction, Fertility and Development, 35 (2), pp. 244-244, 2022, ⟨10.1071/RDv35n2Ab230⟩
Proceedings/Recueil des communications hal-04444899v1