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Pascale Chavatte-Palmer

Pascale Chavatte-Palmer, INRAE Director of the BREED Research unit, University Paris-Saclay, INRAE, University Versailles Saint-Quentin, Ecole nationale Vétérinaire d'Alfort France
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Présentation

**Directrice de l'unité Mixte de Recherches Biologie de la Reproduction, Environnement, Epigénétique et Développement** Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France Ecole Nationale Vétérinaire d’Alfort, BREED, 94700, Maisons-Alfort, France Initially trained as a veterinarian, I specialized in animal, and particularly equine reproduction with a focus on pregnancy and neonatology through my internship, residency and PhD, post-doctoral fellowship and initial position. After my recruitment at AgroParisTech and subsequently INRAE in France, I have been more widely focusing on feto-placental development and the developmental origins of health and disease (DOHaD), with a dual purpose in agriculture and as biomedical models. The aim of my research is to understand the role of the placenta in the programming of long term post-natal health, in the context of the developmental origins of health and diseases. First as a veterinarian and subsequently to be able to perform longitudinal studies in research animals, I have also been developing in vivo imaging technologies such as ultrasound and Doppler to assess placental feto-placental development and placental perfusion. After having led a research group at the National Institute of Agronomical Research (now INRAE), with a mean of 12 permanent staff for the past 14 years, I have recently taken the lead of the new Biology of Reproduction, Environment, Epigenetics and Development (BREED) research unit (90 permanent staff), focusing on the development of the mammalian embryo from the formation of the egg cell to birth and development to adulthood. Projects range from fundamental studies on the functioning of the genome during embryo and fetal growth to applied research on the effects of the environment at large on development in the agronomic, veterinary and biomedical fields. The scientific objective is to understand and control the mechanisms of epigenetic programming during prenatal life, leading to the birth of a healthy, fertile and robust individual, able to adapt to changes in his environment. Meanwhile, I pursue my own research programs on effects of maternal and post-natal breeding conditions, including nutrition, on metabolic and osteoarticular outcomes in the foal. I have served as PI or co-PIU to several national and European research projects (see section D).

Publications

"nathalie-sermondade"
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Sedentary behavior, physical inactivity and body composition in relation to idiopathic infertility among men and women

Aude-Marie Foucaut , Céline Faure , Chantal Julia , Sébastien Czernichow , Rachel Levy
PLoS ONE, 2019, 14 (4), ⟨10.1371/journal.pone.0210770⟩
Article dans une revue hal-02628070v1

Are superoxide dismutase 2 and nitric oxide synthase polymorphisms associated with idiopathic infertility?

Cecile Faure , Pauline Leveillé , Charlotte C. Dupont , Chantal Julia , Pascale Chavatte-Palmer
Antioxidants and Redox Signaling, 2014, 21 (4), pp.565-569. ⟨10.1089/ars.2014.5831⟩
Article dans une revue hal-02638153v1
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Body mass index is not associated with sperm-zona pellucida binding ability in subfertile males

Nathalie Sermondade , Charlotte Dupont , Celine Faure , Marouane Boubaya , Isabelle Cedrin-Durnerin
Asian Journal of Andrology, 2013, 15 (5), pp.626 - 629. ⟨10.1038/aja.2013.10⟩
Article dans une revue hal-01053105v1
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Obesity leads to higher risk of sperm DNA damage in infertile patients

Charlotte Dupont , Celine Faure , Nathalie Sermondade , Marouane Boubaya , Florence Eustache
Asian Journal of Andrology, 2013, 15 (5), pp.622 - 625. ⟨10.1038/aja.2013.65⟩
Article dans une revue hal-01003385v1

Nutrition et grossesse : du marché au bébé...

Charlotte Dupont , Catherine Faure , N. Sermondade , Pauline Leveillé , Pascale Chavatte-Palmer
La Revue Sage-Femme, 2012, 11 (1), pp.22-28. ⟨10.1016/j.sagf.2012.01.007⟩
Article dans une revue hal-01190522v1

Origine développementale des maladies de l'adulte et reproduction

Charlotte Dupont , Nathalie Sermondade , Céline Faure , Pascale Chavatte-Palmer , Rachel Levy
Médecine Thérapeutique. Médecine de la Reproduction, Gynécologie, Endocrinologie, 2011, 13 (4), pp.265-274. ⟨10.1684/mte.2011.0375⟩
Article dans une revue hal-01019371v1

L’obésité augmente le risque d’altération de l’ADN spermatique

Charlotte Dupont , N. Sermondade , C. Faure , M. Boubaya , F. Eustache
17. Journées Nationales de la Fédération Française d'Etude de la Reproduction, Sep 2012, Paris, France. , 1 p., 2012
Poster de conférence hal-02810960v1