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Pascale Chavatte-Palmer

Pascale Chavatte-Palmer, INRAE Director of the BREED Research unit, University Paris-Saclay, INRAE, University Versailles Saint-Quentin, Ecole nationale Vétérinaire d'Alfort France
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Présentation

**Directrice de l'unité Mixte de Recherches Biologie de la Reproduction, Environnement, Epigénétique et Développement** Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France Ecole Nationale Vétérinaire d’Alfort, BREED, 94700, Maisons-Alfort, France Initially trained as a veterinarian, I specialized in animal, and particularly equine reproduction with a focus on pregnancy and neonatology through my internship, residency and PhD, post-doctoral fellowship and initial position. After my recruitment at AgroParisTech and subsequently INRAE in France, I have been more widely focusing on feto-placental development and the developmental origins of health and disease (DOHaD), with a dual purpose in agriculture and as biomedical models. The aim of my research is to understand the role of the placenta in the programming of long term post-natal health, in the context of the developmental origins of health and diseases. First as a veterinarian and subsequently to be able to perform longitudinal studies in research animals, I have also been developing in vivo imaging technologies such as ultrasound and Doppler to assess placental feto-placental development and placental perfusion. After having led a research group at the National Institute of Agronomical Research (now INRAE), with a mean of 12 permanent staff for the past 14 years, I have recently taken the lead of the new Biology of Reproduction, Environment, Epigenetics and Development (BREED) research unit (90 permanent staff), focusing on the development of the mammalian embryo from the formation of the egg cell to birth and development to adulthood. Projects range from fundamental studies on the functioning of the genome during embryo and fetal growth to applied research on the effects of the environment at large on development in the agronomic, veterinary and biomedical fields. The scientific objective is to understand and control the mechanisms of epigenetic programming during prenatal life, leading to the birth of a healthy, fertile and robust individual, able to adapt to changes in his environment. Meanwhile, I pursue my own research programs on effects of maternal and post-natal breeding conditions, including nutrition, on metabolic and osteoarticular outcomes in the foal. I have served as PI or co-PIU to several national and European research projects (see section D).

Publications

"rachel-levy"
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Robotisation de la fécondation in vitro : avantages, état actuel et perspectives

Edison Gerena , Charlotte Dupont , Bernadette B. Banrezes , Pascale Chavatte-Palmer , Rachel Levy
Médecine de la Reproduction, inPress, ⟨10.1684/mte.2024.0992⟩
Article dans une revue hal-04513438v1

Female ponderal index at birth and idiopathic infertility

Charlotte Dupont , Audrey Hulot , Florence Jaffrezic , Céline Faure , Sébastien Czernichow
Journal of Developmental Origins of Health and Disease, 2020, 11 (2), pp.154-158. ⟨10.1017/S2040174419000394⟩
Article dans une revue hal-02197023v1
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Metabolic syndrome and smoking are independent risk factors of male idiopathic infertility

Charlotte Dupont , Céline Faure , Frederic Daoud , Benoit Gautier , Sébastien Czernichow
Basic and clinical andrology, 2019, 29, pp.9. ⟨10.1186/s12610-019-0090-x⟩
Article dans une revue hal-02263110v1

Impact of a gestational exposure to diesel exhaust on offspring gonadal development: experimental study in the rabbit.

Mathilde Bourdon , Laura Torres-Rovira , Danielle Monniaux , Catherine Archilla , R Levy
Journal of Developmental Origins of Health and Disease, 2018, 9 (5), pp.519-529. ⟨10.1017/S2040174418000351⟩
Article dans une revue hal-02621655v1

Are superoxide dismutase 2 and nitric oxide synthase polymorphisms associated with idiopathic infertility?

Cecile Faure , Pauline Leveillé , Charlotte C. Dupont , Chantal Julia , Pascale Chavatte-Palmer
Antioxidants and Redox Signaling, 2014, 21 (4), pp.565-569. ⟨10.1089/ars.2014.5831⟩
Article dans une revue hal-02638153v1

Maternal high-fat diet induces follicular atresia but does not affect fertility in adult rabbit offspring

Pauline Léveillé , Anne Couturier-Tarrade , Charlotte Dupont , Thibaut Larcher , Michèle Dahirel
Journal of Developmental Origins of Health and Disease, 2014, 5 (2), pp.88-97. ⟨10.1017/S2040174414000014⟩
Article dans une revue hal-03609938v1

Impact of maternal hyperlipidic hypercholesterolaemic diet on male reproductive organs and testosterone concentration in rabbits

Charlotte C. Dupont , Delphine Rousseau-Ralliard , Anne Couturier-Tarrade , C. Faure , Michèle Dahirel
Journal of Developmental Origins of Health and Disease, 2014, 5 (3), pp.183-188. ⟨10.1017/S204017/4414000087⟩
Article dans une revue hal-02630542v1
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Obesity leads to higher risk of sperm DNA damage in infertile patients

Charlotte Dupont , Celine Faure , Nathalie Sermondade , Marouane Boubaya , Florence Eustache
Asian Journal of Andrology, 2013, 15 (5), pp.622 - 625. ⟨10.1038/aja.2013.65⟩
Article dans une revue hal-01003385v1
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Dietary lipid and cholesterol induce ovarian dysfunction and abnormal LH response to stimulation in rabbits

Anne Gaël Cordier , Pauline Leveille , Charlotte Dupont , Anne Couturier-Tarrade , Olivier Picone
PLoS ONE, 2013, 8 (5), pp.1-11. ⟨10.1371/journal.pone.0063101⟩
Article dans une revue hal-01004078v1
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Body mass index is not associated with sperm-zona pellucida binding ability in subfertile males

Nathalie Sermondade , Charlotte Dupont , Celine Faure , Marouane Boubaya , Isabelle Cedrin-Durnerin
Asian Journal of Andrology, 2013, 15 (5), pp.626 - 629. ⟨10.1038/aja.2013.10⟩
Article dans une revue hal-01053105v1

Origines développementales de la santé et des maladies de l'adulte : rôle de l'environnement maternel

Pascale Chavatte-Palmer , Anne Couturier-Tarrade , Rachel Levy
Gynécologie Obstétrique & Fertilité, 2012, 40 (9), pp.517-519. ⟨10.1016/j.gyobfe.2012.07.010⟩
Article dans une revue hal-01190418v1

Maternal environment and the reproductive function of the offspring

Charlotte Dupont , Anne Gaël Cordier , Claudine Junien , Béatrice Mandon-Pepin , Rachel Levy
Theriogenology, 2012, 78 (7), pp.1405-1414. ⟨10.1016/j.theriogenology.2012.06.016⟩
Article dans une revue hal-01190203v1

Origine développementale des maladies de l'adulte et reproduction

Charlotte Dupont , Nathalie Sermondade , Céline Faure , Pascale Chavatte-Palmer , Rachel Levy
Médecine Thérapeutique. Médecine de la Reproduction, Gynécologie, Endocrinologie, 2011, 13 (4), pp.265-274. ⟨10.1684/mte.2011.0375⟩
Article dans une revue hal-01019371v1
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Les apports de la génétique et de l’épigénétique :

Pascale Chavatte-Palmer , Rachel Lévy
Colloque du samedi 9 décembre 2023 dans le cadre de la commémoration du 75 ème anniversaire de la convention de l'ONU pour la prévention et la répression du crime de génocide, Musée de l'Homme; ANA S-J « Avenirs de Femmes », Dec 2023, Paris ( France), France
Communication dans un congrès hal-04342317v1

Effects of a preconceptional and gestational mutli-vitamin-mineral-omega3 supplementation on fetoplacental development in a rabbit model

Eve Mourier , Anne Couturier-Tarrade , Delphine Rousseau-Ralliard , Thibaut Larcher , Jean-Pierre Albert
40th Annual Conference of the IETS, International Embryo Transfer Society (IETS). USA., Jan 2014, Reno, Nevada, United States. pp.150, ⟨10.1071/RDv26n1Ab72⟩
Communication dans un congrès hal-01019240v1

Effets d’une supplémentation multi-vitamines-minéraux-oméga3 préconceptionnelle et gestationnelle sur le développement fœtoplacentaire dans un modèle lapin

Eve Mourier , Anne Couturier-Tarrade , Delphine Rousseau-Ralliard , Thibaut Larcher , Jean-Pierre Albert
Journées nationales de la société française de médecine périnatale, Nov 2013, Monaco, R.A.S. chinoise de Macao
Communication dans un congrès hal-01189852v1

In utero. L'origine développementale de la santé et des maladies (DOHaD), une science en évolution

Claudine C. Junien , Pascale Chavatte-Palmer , Isabelle I. Cédrin-Durnerin , Rachel Levy , Joëlle J. Belaisch-Allart
1. Congrès de Médecine Périconceptionnelle, Mar 2012, Paris, France. pp.4-11
Communication dans un congrès hal-01000839v1

Une reproduction sans utérus? État des lieux de l'ectogenèse

Pascale Chavatte-Palmer , Rachel Levy , P Boileau
43. Journée thématique de la SFEF, Société Française pour l'Etude de la Fertilité (SFEF). FRA., Mar 2012, Paris, France. ⟨10.1016/j.gyobfe.2012.09.008⟩
Communication dans un congrès hal-01190417v1

Maternal nutrition and its effects on offspring fertility and importance of the periconceptional period on long-term development

Charlotte C. Dupont , Anne Gaël Cordier , Claudine Junien , Rachel Levy , Pascale Chavatte-Palmer
The Molecular Basis for the link between maternal Health and Origin of Fetal Congenital Abnormalities: An overview of Association with Oxidative Stress., Bentham Science Publishers Ltd., pp.128, 2011, 978-1-60805-286-8. ⟨10.2174/97816080528681110101⟩
Chapitre d'ouvrage hal-02809769v1

Effets d’une supplémentation multi-vitamines, minéraux, Oméga 3, préconceptionelle et gestationnelle sur le développement foetoplacentaire dans un modèle lapin

Eve Mourier Mourier , Anne Couturier-Tarrade , Delphine Rousseau-Ralliard , Thibaut T. Larcher , Jean-Pierre Albert
43. Journées Nationales de la Société Française de Médecine Périnatale, Nov 2013, Monaco, France. Editions Springer, Revue de Médecine Périnatale, 5 (Supplément 1), 164 p., 2013, 43es Journées Nationales de la Société Française de Médecine Périnatale
Poster de conférence hal-02747523v1

Role of leptin in milk for development programming using a rabbit model

Charlotte C. Dupont , Anne Couturier-Tarrade , Sylvaine S. Camous , Madia Charlier , Rachel Levy
GEMINI Group III Workshop, May 2011, Jerusalem, Israel. Cost Office, pp.65, 2011, GEMINI Periconceptional Developmental Programming
Poster de conférence hal-02747404v1