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Pascale Chavatte-Palmer

Pascale Chavatte-Palmer, INRAE Director of the BREED Research unit, University Paris-Saclay, INRAE, University Versailles Saint-Quentin, Ecole nationale Vétérinaire d'Alfort France
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Présentation

**Directrice de l'unité Mixte de Recherches Biologie de la Reproduction, Environnement, Epigénétique et Développement** Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France Ecole Nationale Vétérinaire d’Alfort, BREED, 94700, Maisons-Alfort, France Initially trained as a veterinarian, I specialized in animal, and particularly equine reproduction with a focus on pregnancy and neonatology through my internship, residency and PhD, post-doctoral fellowship and initial position. After my recruitment at AgroParisTech and subsequently INRAE in France, I have been more widely focusing on feto-placental development and the developmental origins of health and disease (DOHaD), with a dual purpose in agriculture and as biomedical models. The aim of my research is to understand the role of the placenta in the programming of long term post-natal health, in the context of the developmental origins of health and diseases. First as a veterinarian and subsequently to be able to perform longitudinal studies in research animals, I have also been developing in vivo imaging technologies such as ultrasound and Doppler to assess placental feto-placental development and placental perfusion. After having led a research group at the National Institute of Agronomical Research (now INRAE), with a mean of 12 permanent staff for the past 14 years, I have recently taken the lead of the new Biology of Reproduction, Environment, Epigenetics and Development (BREED) research unit (90 permanent staff), focusing on the development of the mammalian embryo from the formation of the egg cell to birth and development to adulthood. Projects range from fundamental studies on the functioning of the genome during embryo and fetal growth to applied research on the effects of the environment at large on development in the agronomic, veterinary and biomedical fields. The scientific objective is to understand and control the mechanisms of epigenetic programming during prenatal life, leading to the birth of a healthy, fertile and robust individual, able to adapt to changes in his environment. Meanwhile, I pursue my own research programs on effects of maternal and post-natal breeding conditions, including nutrition, on metabolic and osteoarticular outcomes in the foal. I have served as PI or co-PIU to several national and European research projects (see section D).

Publications

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Analysis of Predictive Factors for Successful Vascular Anastomoses in a Sheep Uterine Transplantation Model

Claire Le Gal , Marie Carbonnel , Vincent Balaya , Christophe Richard , Valerie Gelin
Journal of Clinical Medicine, 2022, 11, pp.5262. ⟨10.3390/jcm11185262⟩
Article dans une revue hal-03770597v1
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Involving Animal Models in Uterine Transplantation

Angeline Favre-Inhofer , Marie Carbonnel , Johanna Domert , Nathalie Cornet , Sylvie Chastant
Frontiers in Surgery, 2022, 9, pp.830826. ⟨10.3389/fsurg.2022.830826⟩
Article dans une revue hal-03588798v1
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Analysis of blood parameters and molecular endometrial markers during early reperfusion in two ovine models of uterus transplantation

Marie Carbonnel , Nathalie Cornet , Aurélie Revaux , Angéline Favre-Inhofer , Laurent Galio
PLoS ONE, 2021, 16 (5), pp.e0251474. ⟨10.1371/journal.pone.0251474⟩
Article dans une revue hal-03232288v1
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Pressurized intra-peritoneal aerosol chemotherapy (PIPAC): increased intraperitoneal pressure does not affect distribution patterns but leads to deeper penetration depth of doxorubicin in a sheep model

Myriam Mimouni , Christophe Richard , Pierre Adenot , Martine Letheule , Anne Couturier-Tarrade
BMC Cancer, 2021, 21, pp.461. ⟨10.1186/s12885-021-07955-w⟩
Article dans une revue hal-03211408v1

Critical steps for initiating an animal uterine transplantation model in sheep: experience from a case serie.

Angeline Favre-Inhofer , Marie Carbonnel , Aurélie Revaux , Olivier Sandra , Valérie Mougenot
International Journal of Surgery, 2018, 60, pp.245-251. ⟨10.1016/j.ijsu.2018.11.017⟩
Article dans une revue hal-02623603v1

Transcervical collection of bovine embryos up to Day 21: An 8-year overview

Christophe Richard , Isabelle Hue , Valerie Gelin , Alexandre Neveux , Evelyne E. Campion
Theriogenology, 2015, 83 (7), pp.1101-1109. ⟨10.1016/j.theriogenology.2014.12.005⟩
Article dans une revue hal-02630658v1

Effect of Maternal Exposure to a Cocktail of Food Contaminants on Feto-Placental Development and Growth in a Rabbit Model

Jeanne Bozec , Delphine Rousseau-Ralliard , Christophe Richard , Valerie Gelin , Audrey Prézelin
European Placenta Group, Nov 2022, Jouy-en-Josas, France
Communication dans un congrès hal-03883821v1

Exposition maternelle aux nanoparticules métalliques (Au-pvp, Ag, CeO2) par instillation: effets sur la fonction placentaire et le phénotype fœtal.

Anne Couturier-Tarrade , Delphine Rousseau-Ralliard , Audrey Geeverding , Luc Jouneau , Valerie Gelin
SF-DOHaD, Nov 2021, Jouy-en-Josas, France
Communication dans un congrès hal-03483311v1

Effets de l'exposition aux nanoparticules d'or par inhalation sur la fonction placentaire et le phénotype de la descendance

Delphine Rousseau-Ralliard , Valérie Fessard , Michèle Dahirel , John Boere , Christophe Richard
GFP-Groupe de la Francophonie Placentaire, Sep 2021, Nantes, France
Communication dans un congrès hal-03341279v1
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Effets de l’exposition maternelle aux nanoparticules d’or par ingestion, pendant la gestation, sur le développement foeto-placentaire et la fonction placentaire, dans un modèle lapin.

Camille Rousseau , Delphine Rousseau-Ralliard , Michèle Dahirel , Luc Jouneau , Josiane Aioun
7. Rencontre du Groupe de la Francophonie Placentaire 2019, Groupe de la francophonie Placentaire (GfP). FRA., Mar 2019, Paris, France. 36 p
Communication dans un congrès hal-02734084v1
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Effects of maternal au-np exposure by inhalation on foeto-placental development and placental function, in a rabbit model

Delphine Rousseau-Ralliard , Valérie Fessard , John A. Boere , Paul Fokkens , Michèle Dahirel
IPTC, Sep 2019, Salzburg, Austria
Communication dans un congrès hal-02733978v1

Autotransplantation utérine dans un modèle ovin

Nathalie Cornet , Marie Carbonnel , Aurélie Revaux , Raphaël Coscas , Christophe Richard
16. journée de chirurgie gynécologique et pelvienne (SCGP) « La chirurgie gynécologique à l’heure de la francophonie », Sep 2019, Lille, France
Communication dans un congrès hal-02785848v1
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Effets de l’exposition maternelle aux nanoparticules d’or par ingestion pendant la gestation, sur le développement foeto-placentaire et la fonction placentaire, dans un modèle lapin

Camille Rousseau , Delphine Rousseau-Ralliard , Michèle Dahirel , Christophe Richard , Luc Jouneau
4. Congrès de la SF-Dohad, Société Francophone-DOHaD. FRA., Nov 2018, Grenoble, France. pp.120
Communication dans un congrès hal-02734001v1

Courbe d'apprentissage de la transplantation utérine chez la brebis

Angeline Favre-Inhofer , Marie Carbonnel , Aurélie Revaux , Olivier Sandra , Romain Bosc
42. Journées Nationales du CNGOF, Collège National des Gynécologues et Obstétriciens Français. FRA., Dec 2018, Strasbourg, France
Communication dans un congrès hal-02736608v1
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Embryo collection in clone cattle offspring

Christophe Richard , Valerie Gelin , Alexandre Neveux , Isabelle Hue , Yvan Heyman
31. Colloque Scientifique de l'AETE, Association Européenne de Transfert Embryonnaire - European Embryo Transfer Association (AETE). FRA., Sep 2015, Ghent, Belgium
Communication dans un congrès hal-02740072v1

Transcervical embryo collection in late stage in cattle

Christophe Richard , Valerie Gelin , Alexandre Neveux , Isabelle Hue , Yvan Heyman
29. Annual Meeting AETE 2013, Association Européenne de Transfert Embryonnaire - European Embryo Transfer Association (AETE). FRA., Sep 2013, Istanbul, Turkey. pp.194
Communication dans un congrès hal-01019550v1

Birth and characteristics of clone offspring: preliminary results.

Christophe Richard , Pascale Chavatte-Palmer , Valerie Gelin , Yvan Heyman
24. Scientific Meeting AETE, Sep 2008, Pau, France
Communication dans un congrès hal-02750683v1