Pascale MARCHOT

Présentation

AFMB lab (AMU-CNRS)

&quot;Architecture et Fonction des Macromolécules Biologiques&quot; laboratory

Publications

Article dans une revue (88)

Report from the 31st Meeting on Toxinology, “Toxins: Playing with and Fighting Them!”, Organized by the French Society for Toxinology on 1–2 December 2025 Sylvie Diochot,Raphaële Le Garrec,Michel M Dugon,Pascale Marchot Toxins, 2026, 18 (3), pp.138. ⟨10.3390/toxins18030138⟩ Article dans une revue hal-05550916v1
Report from the 30th Meeting on Toxinology, &quot;Unlocking the Deep Secrets of Toxins&quot;, Organized by the French Society of Toxinology on 2-3 December 2024 Pascale Marchot,Ziad Faljoun,Évelyne Benoit,Sylvie Diochot Toxins, 2025, 17 (94), pp.1-31. ⟨10.3390/toxins17020000⟩ Article dans une revue hal-04948435v2
Report from the 29th Meeting on Toxinology, “Toxins: From the Wild to the Lab”, Organized by the French Society of Toxinology on 30 November–1 December 2023 Pascale Marchot,Ziad Fajloun,Christian Legros,Évelyne Benoit,Sylvie Diochot Toxins, 2024, 16 (3), pp.147. ⟨10.3390/toxins16030147⟩ Article dans une revue hal-04508917v1
Web of venom: exploration of big data resources in animal toxin research Giulia Zancolli,Björn Marcus von Reumont,Gregor Anderluh,Figen Caliskan,Maria Luisa Chiusanoet al. GigaScience, 2024, 13, pp.giae054. ⟨10.1093/gigascience/giae054⟩ Article dans une revue hal-04693027v1
The cyclic imine core common to the marine macrocyclic toxins is sufficient to dictate nicotinic acetylcholine receptor antagonism Yves Bourne,Gerlind Sulzenbacher,Laurent Chabaud,Rómulo Aráoz,Zoran Radićet al. Marine drugs, 2024, Marine Biotoxins 2.0, 22 (4), pp.149. ⟨10.3390/md22040149⟩ Article dans une revue hal-04542228v1
Report from the 28th Meeting on Toxinology, “Toxins: What’s up, Doc?”, Organized by the French Society of Toxinology on 28–29 November 2022 Pascale Marchot,Évelyne Benoit,Ziad Fajloun,Sylvie Diochot Toxins, 2023, 15 (126), pp.1-25. ⟨10.3390/toxins15020126⟩ Article dans une revue hal-03978955v1
The ESTHER database on alpha/beta hydrolase fold proteins - An overview of recent developments Arnaud Chatonnet,Michel Perochon,Eric Velluet,Pascale Marchot Chemico-Biological Interactions, 2023, 383, pp.110671. ⟨10.1016/j.cbi.2023.110671⟩ Article dans une revue hal-04195109v1
Obituary - Hervé Paul Marie Antoine ROCHAT 1937–2023 Marie-France Martin-Eauclaire,Pascale Marchot Toxicon, 2023, 233, pp.107249. ⟨10.1016/j.toxicon.2023.107249⟩ Article dans une revue hal-04195329v1
Report from the 27th (Virtual) Meeting on Toxinology, “Toxins: Mr Hyde or Dr Jekyll?”, Organized by the French Society of Toxinology, 9–10 December 2021 Daniel Ladant,Pascale Marchot,Sylvie Diochot,Gilles Prévost,Michel Popoffet al. Toxins, 2022, 14 (110), pp.1-32. ⟨10.3390/toxins14020110⟩ Article dans une revue hal-03551958v1
Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1 Jorge Ramirez-Franco,Kévin Debreux,Johanna Extremet,Yves Maulet,Maya Belghaziet al. Brain - A Journal of Neurology , 2022, pp.awac218. ⟨10.1093/brain/awac218⟩ Article dans une revue hal-03701887v1
Comparative mapping of selected structural determinants on the extracellular domains of cholinesterase-like cell-adhesion molecules. Davide Comoletti,Laura Trobiani,Arnaud Chatonnet,Yves Bourne,Pascale Marchot Neuropharmacology, 2021, 184, pp.108381. ⟨10.1016/j.neuropharm.2020.108381⟩ Article dans une revue hal-03021748v1
The neuroligins and the synaptic pathway in Autism Spectrum Disorder. Laura Trobiani,Maria Meringolo,Tamara Diamanti,Yves Bourne,Pascale Marchotet al. Neuroscience and Biobehavioral Reviews, 2020, 119, pp.37-51. ⟨10.1016/j.neubiorev.2020.09.017⟩ Article dans une revue hal-03021773v1
The Ig-like domain of Punctin/MADD-4 is the primary determinant for interaction with the ectodomain of neuroligin NLG-1 Semeli Platsaki,Xin Zhou,Bérangère Pinan-Lucarré,Vincent Delauzun,Haijun Tuet al. Journal of Biological Chemistry, 2020, pp.16267-16279. ⟨10.1074/jbc.RA120.014591⟩ Article dans une revue hal-03021788v1
Report from the 26th Meeting on Toxinology, Bioengineering of Toxins, Organized by the French Society of Toxinology (SFET) and Held in Paris, France, 4-5 December 2019 Pascale Marchot,Sylvie Diochot,Michel R Popoff,Evelyne Benoit Toxins, 2020, 12 (E31), pp.1-30. ⟨10.3390/toxins12010031⟩ Article dans une revue hal-02441465v1
An evolutionary perspective on the first disulfide bond in members of the cholinesterase-carboxylesterase (COesterase) family: Possible outcomes for cholinesterase expression in prokaryotes Arnaud Chatonnet,Xavier Brazzolotto,Thierry Hotelier,Nicolas Lenfant,Pascale Marchotet al. Chemico-Biological Interactions, 2019, 308 (308), pp.179-184. ⟨10.1016/j.cbi.2019.05.016⟩ Article dans une revue hal-02269496v1
Hot Spots for Protein Partnerships at the Surface of Cholinesterases and Related α/β Hydrolase Fold Proteins or Domains—A Structural Perspective Yves Bourne,Pascale Marchot Molecules, 2018, 23 (1), ⟨10.3390/molecules23010035⟩ Article dans une revue hal-01802955v1
Cyclic imine toxins from dinoflagellates: a growing family of potent antagonists of the nicotinic acetylcholine receptors Jordi Molgó,Pascale Marchot,Rómulo Aráoz,Evelyne Benoit,Bogdan I Iorgaet al. Journal of Neurochemistry, 2017, 142, pp.41 - 51. ⟨10.1111/jnc.13995⟩ Article dans une revue hal-01661784v1
Natural genomic amplification of cholinesterase genes in animals Arnaud Chatonnet,Nicolas Lenfant,Pascale Marchot,Murray E. Selkirk Journal of Neurochemistry, 2017, Cholinergic Mechanisms, 142 (2), pp.73-81. ⟨10.1111/jnc.13990⟩ Article dans une revue hal-01608096v1
The three-finger toxin fold: a multifunctional structural scaffold able to modulate cholinergic functions Pascal Kessler,Pascale Marchot,Marcela Silva,Denis Servent Journal of Neurochemistry, 2017, 142, pp.7 - 18. ⟨10.1111/jnc.13975⟩ Article dans une revue hal-01802811v1
Preface: Cholinergic Mechanisms Marco Prado,Pascale Marchot,Israel Silman,Marco A.M. Prado Journal of Neurochemistry, 2017, 142, pp.3 - 6. ⟨10.1111/jnc.14027⟩ Article dans une revue hal-01802851v1
A Triad of Crystals Sheds Light on MDGA Interference with Neuroligation Olivier Thoumine,Pascale Marchot Neuron, 2017, 95 (4), pp.729 - 732. ⟨10.1016/j.neuron.2017.08.001⟩ Article dans une revue hal-01802853v1
Relationships of human alpha/beta hydrolase fold proteins and other organophosphate-interacting proteins Nicolas Lenfant,Yves Bourne,Pascale Marchot,Arnaud Chatonnet Chemico-Biological Interactions, 2016, 259 (B, SI), pp.343-351. ⟨10.1016/j.cbi.2016.04.027⟩ Article dans une revue hal-01439103v1
Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase Yves Bourne,K. Barry Sharpless,Palmer Taylor,Pascale Marchot Journal of the American Chemical Society, 2016, 138 (5), pp.1611-1621. ⟨10.1021/jacs.5b11384⟩ Article dans une revue hal-01439081v1
Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal α7 from Muscle α12βγδ nAChRs. Yves Bourne,Gerlind Sulzenbacher,Zoran Radić,Rómulo Aráoz,Morgane Reynaudet al. Structure, 2015, 23 (6), pp.1106-15. ⟨10.1016/j.str.2015.04.009⟩ Article dans une revue hal-01178822v1
Crystal structure of snake venom acetylcholinesterase in complex with inhibitory antibody fragment Fab410 bound at the peripheral site - Evidence for open and closed states of a back door channel Yves Bourne,Ludovic Renault,Pascale Marchot Journal of Biological Chemistry, 2015, 290 (3), pp.1522-1535. ⟨10.1074/jbc.M114.603902⟩ Article dans une revue hal-01439005v1
The neuroligins and their neurexin ligands: from structure to function at the synapse Yves Bourne,Pascale Marchot Journal of Molecular Neuroscience, 2014, 53, pp.387-396. ⟨10.1007/s12031-014-0234-6⟩ Article dans une revue hal-03270068v1
Special Issue on “freshwater and marine toxins” Evelyne Benoit,César Mattei,Julien Barbier,Pascale Marchot,Jordi Molgóet al. Toxicon, 2014, 91, pp.1-4. ⟨10.1016/j.toxicon.2014.11.217⟩ Article dans une revue istex hal-04215133v1
Tracking the origin and divergence of cholinesterases and neuroligins: the evolution of synaptic proteins Nicolas Lenfant,Thierry Hotelier,Yves Bourne,Pascale Marchot,Arnaud Chatonnet Journal of Molecular Neuroscience, 2014, 53 (3), pp.362-369. ⟨10.1007/s12031-013-0194-2⟩ Article dans une revue hal-01190082v1
Editorial : Special Issue on &quot;freshwater and marine toxins&quot;. Evelyne Benoit,César Mattei,Julien Barbier,Pascale Marchot,Jordi Molgóet al. Toxicon, 2014, 91, pp.1-4. ⟨10.1016/j.toxicon.2014.11.217⟩ Article dans une revue istex hal-01165542v1
ESTHER, the database of the α/β-hydrolase fold superfamily of proteins: tools to explore diversity of functions Nicolas Lenfant,Thierry Hotelier,Eric Velluet,Yves Bourne,Pascale Marchotet al. Nucleic Acids Research, 2013, 41, pp.423-429. ⟨10.1093/nar/gks1154⟩ Article dans une revue hal-01218998v1
Molecular Characterization of Monoclonal Antibodies that Inhibit Acetylcholinesterase by Targeting the Peripheral Site and Backdoor Region Yves Bourne,Ludovic Renault,Sosthène Essono,Grégoire Mondielli,Patricia Lamouretteet al. PLoS ONE, 2013, 8, pp.e77226. ⟨10.1371/journal.pone.0077226⟩ Article dans une revue hal-01771534v1
Editorial : Special issue on &quot;toxins: from threats to benefits&quot;. Marie-France Martin-Eauclaire,Evelyne Benoit,Pascale Marchot,Julien Barbier,Jordi Molgóet al. Toxicon, 2013, 75, pp.1-2. ⟨10.1016/j.toxicon.2013.08.001⟩ Article dans une revue hal-00919888v1
Proteins with an alpha/beta hydrolase fold: Relationships between subfamilies in an ever-growing superfamily. Nicolas Lenfant,Thierry Hotelier,Yves Bourne,Pascale Marchot,Arnaud Chatonnet Chemico-Biological Interactions, 2013, 203 (1), pp.266-268. ⟨10.1016/j.cbi.2012.09.003⟩ Article dans une revue istex hal-01837554v1
Enzymatic activity and protein interactions in alpha/beta hydrolase fold proteins: moonlighting versus promiscuity. Pascale Marchot,Arnaud Chatonnet Protein and Peptide Letters, 2012, 19 (2), pp.132-143. ⟨10.2174/092986612799080284⟩ Article dans une revue hal-00755665v1
Structural Insights into Antibody Sequestering and Neutralizing of Na+ Channel α-Type Modulator from Old World Scorpion Venom. Igor P Fabrichny,Grégoire Mondielli,Sandrine Conrod,Marie-France Martin-Eauclaire,Yves Bourneet al. Journal of Biological Chemistry, 2012, 287 (17), pp.14136-48. ⟨10.1074/jbc.M111.315382⟩ Article dans une revue hal-00701162v1
Hydrolase versus other functions of members of the alpha/beta-hydrolase fold superfamily of proteins. Pascale Marchot,Arnaud Chatonnet Protein and Peptide Letters, 2012, 19 (2), pp.130-131. ⟨10.2174/092986612799080239⟩ Article dans une revue hal-00755664v1
Structure-function relationships of the alpha/beta-hydrolase fold domain of neuroligin: A comparison with acetylcholinesterase. Philippe Leone,Davide Comoletti,Palmer Taylor,Yves Bourne,Pascale Marchot Chemico-Biological Interactions, 2010, epub ahead of print. ⟨10.1016/j.cbi.2010.01.030⟩ Article dans une revue istex hal-00482300v1
Insecticide resistance through mutations in cholinesterases or carboxylesterases : data mining in the ESTHER database Thierry Hotelier,Vincent Negre,Pascale Marchot,Arnaud Chatonnet Journal of Pesticide Science, 2010, 35 (3), pp.315-320. ⟨10.1584/jpestics.R10-10⟩ Article dans une revue hal-02661971v1
Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions. Philippe Leone,Davide Comoletti,Géraldine Ferracci,Sandrine Conrod,Simon U Garciaet al. EMBO Journal, 2010, 29 (14), pp.2461-71. ⟨10.1038/emboj.2010.123⟩ Article dans une revue hal-00625337v1
Conformational remodeling of femtomolar inhibitor-acetylcholinesterase complexes in the crystalline state. Yves Bourne,Zoran Radić,Palmer Taylor,Pascale Marchot Journal of the American Chemical Society, 2010, 132 (51), pp.18292-300. ⟨10.1021/ja106820e⟩ Article dans une revue hal-00625332v1
Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism. Yves Bourne,Zoran Radic,Rómulo Aráoz,Todd T Talley,Evelyne Benoitet al. Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (13), pp.6076-81. ⟨10.1073/pnas.0912372107⟩ Article dans une revue hal-00464306v1
Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor Ryan Hibbs,Gerlind Sulzenbacher,Jianxin Shi,Todd Talley,Sandrine Conrodet al. EMBO Journal, 2009, 28 (19), pp.3040 - 3051. ⟨10.1038/emboj.2009.227⟩ Article dans une revue hal-01809973v1
Structural Analysis of the Synaptic Protein Neuroligin and Its β-Neurexin Complex: Determinants for Folding and Cell Adhesion Igor Fabrichny,Philippe Leone,Gerlind Sulzenbacher,Davide Comoletti,Meghan Milleret al. Neuron, 2007, 56 (6), pp.979-991. ⟨10.1016/j.neuron.2007.11.013⟩ Article dans une revue hal-02989328v1
Structural comparison of three crystalline complexes of a peptidic toxin with a synaptic acetylcholine recognition protein. Yves Bourne,Scott B Hansen,Gerlind Sulzenbacher,Todd T Talley,Tom Huxfordet al. Journal of Molecular Neuroscience, 2006, 30 (1-2), pp.103-4 Article dans une revue hal-00134316v1
Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding. Yves Bourne,Zoran Radic,Gerlind Sulzenbacher,Esther Kim,Palmer Tayloret al. Journal of Biological Chemistry, 2006, 281 (39), pp.29256-67. ⟨10.1074/jbc.M603018200⟩ Article dans une revue hal-00134313v1
Structural characterization of agonist and antagonist-bound acetylcholine-binding protein from Aplysia californica. Scott B Hansen,Gerlind Sulzenbacher,Tom Huxford,Pascale Marchot,Yves Bourneet al. Journal of Molecular Neuroscience, 2006, 30 (1-2), pp.101-2 Article dans une revue hal-00134314v1
A. niger protein “EstA”, perhaps a new electrotactin, defines a new class of fungal esterases within the α/β hydrolase fold superfamily Yves Bourne,Alinda Hasper,Henri Chahinian,Ludovic Renault,Marianick Juinet al. Chemico-Biological Interactions, 2005, 157-158, pp.395-396. ⟨10.1016/j.cbi.2005.10.072⟩ Article dans une revue istex hal-03263187v1
Expression of the standard scorpion alpha-toxin AaH II and AaH II mutants leading to the identification of some key bioactive elements C. Legros,B. Ceard,H. Vacher,Pascale Marchot,Bougis P. E.et al. BBA - Biochimica et Biophysica Acta, 2005, 1723, pp.91 99 Article dans une revue hal-00021020v1
New friendly tools for users of ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins, L. Renault,V. Negre,T. Hotelier,Xavier Cousin,Pascale Marchotet al. Chemico-Biological Interactions, 2005, 157-158, pp.339-43. ⟨10.1016/j.cbi.2005.10.100⟩ Article dans une revue istex hal-00018798v1
Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors, Yves Bourne,T. T. Talley,Hansen S. B.,P. Taylor,Pascale Marchot EMBO Journal, 2005, 24, pp.1512-1522 Article dans une revue hal-00021395v1
Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE, Chem Biol Interact. 157-158, 159-65. Yves Bourne,Z. Radic,Kolb H. C.,Sharpless K. B.,P. Tayloret al. Chemico-Biological Interactions, 2005, 157-158, pp.159-65 Article dans une revue hal-00018799v1
Structural insights into AChE inhibition by monoclonal antibodies Ludovic Renault,Sosthène Essono,Marianick Juin,Didier Boquet,Jacques Grassiet al. Chemico-Biological Interactions, 2005, 157-158, pp.397-400. ⟨10.1016/j.cbi.2005.10.073⟩ Article dans une revue istex hal-03263196v1
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations Scott B Hansen,Gerlind Sulzenbacher,Tom Huxford,Pascale Marchot,Palmer Tayloret al. EMBO Journal, 2005, 24 (20), pp.3635-3646. ⟨10.1038/sj.emboj.7600828⟩ Article dans une revue hal-03160548v1
Aspergillus niger Protein EstA Defines a New Class of Fungal Esterases within the α/β Hydrolase Fold Superfamily of Proteins Yves Bourne,Alinda A Hasper,Henri Chahinian,Marianick Juin,Leo H de Graaffet al. Structure, 2004, 12, pp.677 - 687. ⟨10.1016/j.str.2004.03.005⟩ Article dans une revue hal-03263177v1
Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation Y. Bourne,H. Kolb,Z. Radic,K. Sharpless,P. Tayloret al. Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (6), pp.1449-1454. ⟨10.1073/pnas.0308206100⟩ Article dans une revue hal-03263174v1
ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins Thierry Hotelier,Ludovic Renault,Xavier Cousin,Vincent Negre,Pascale Marchotet al. Nucleic Acids Research, 2004, 32, pp.D145-D147. ⟨10.1093/nar/gkh141⟩ Article dans une revue hal-02679326v1
Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site Yves Bourne,Palmer Taylor,Zoran Radic,Pascale Marchot EMBO Journal, 2003, 22 (1), pp.1-12. ⟨10.1093/emboj/cdg005⟩ Article dans une revue hal-03263169v1
Use of a purified and functional recombinant calcium-channel β4 subunit in surface-plasmon resonance studies Sandrine Geib,Guillaume Sandoz,Kamel Mabrouk,Alessandra Matavel,Pascale Marchotet al. Biochemical Journal, 2002, 364 (1), pp.285-292. ⟨10.1042/bj3640285⟩ Article dans une revue hal-03263160v1
Mechanism of Acetylcholinesterase Inhibition by Fasciculin: A 5-ns Molecular Dynamics Simulation Kaihsu Tai,Tongye Shen,Richard Henchman,Yves Bourne,Pascale Marchotet al. Journal of the American Chemical Society, 2002, 124 (21), pp.6153-6161. ⟨10.1021/ja017310h⟩ Article dans une revue istex hal-03263152v1
On the kaliotoxin and dendrotoxin binding sites on rat brain synaptosomes N Tricaud,Pascale Marchot,M.F Martin-Eauclaire Toxicon, 2000, 38 (12), pp.1749-1758. ⟨10.1016/s0041-0101(00)00104-5⟩ Article dans une revue istex hal-03262596v1
Immunocytochemical Localization and Crystal Structure of Human Frequenin (Neuronal Calcium Sensor 1) Yves Bourne,Jens Dannenberg,Verena Pollmann,Pascale Marchot,Olaf Pongs Journal of Biological Chemistry, 2000, 276, pp.11949 - 11955. ⟨10.1074/jbc.m009373200⟩ Article dans une revue hal-03263149v1
L’interaction fasciculine-acétylcholinestérase Pascale Marchot Journal de la Société de Biologie, 1999, 193 (6), pp.505-508. ⟨10.1051/jbio/1999193060505⟩ Article dans une revue istex hal-03363691v1
Electron paramagnetic resonance reveals altered topography of the active center gorge of acetylcholinesterase after binding of fasciculin to the peripheral site Marjeta Šentjurc,Slavko Pečar,Jure Stojan,Pascale Marchot,Zoran Radićet al. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1999, 1430 (2), pp.349-358. ⟨10.1016/s0167-4838(99)00018-7⟩ Article dans une revue istex hal-03262546v1
Conformational Flexibility of the Acetylcholinesterase Tetramer Suggested by X-ray Crystallography* Yves Bourne,Jacques Grassi,Pierre E Bougis,Pascale Marchot Journal of Biological Chemistry, 1999, 274 (43), pp.30370-30376 Article dans une revue hal-03262571v1
Crystal Structure of Mouse Acetylcholinesterase Yves Bourne,Palmer Taylor,Pierre E Bougis,Pascale Marchot Journal of Biological Chemistry, 1999, 274 (5), pp.2963-2970. ⟨10.1074/jbc.274.5.2963⟩ Article dans une revue hal-03262510v1
Inhibition of mouse acetylcholinesterase by fasciculin: Crystal structure of the complex and mutagenesis of fasciculin Pascale Marchot,Yves Bourne,Claudine Prowse,Pierre Bougis,Palmer Taylor Toxicon, 1998, 36 (11), pp.1613-1622. ⟨10.1016/s0041-0101(98)00154-8⟩ Article dans une revue istex hal-03262468v1
Residues at the Subunit Interfaces of the Nicotinic Acetylcholine Receptor That Contribute to α-Conotoxin M1 Binding Naoya Sugiyama,Pascale Marchot,Chiaki Kawanishi,Hitoshi Osaka,Brian Molleset al. Molecular Pharmacology, 1998, 53 (4), pp.787-794. ⟨10.1124/mol.53.4.787⟩ Article dans une revue hal-03262437v1
Toxins selective for subunit interfaces as probes of nicotinic acetylcholine receptor structure Palmer Taylor,Hitoshi Osaka,Brian Molles,Naoya Sugiyama,Pascale Marchotet al. Journal of Physiology - Paris, 1998, 92 (2), pp.79-83. ⟨10.1016/S0928-4257(98)80142-3⟩ Article dans une revue istex hal-03262491v1
Expression and Activity of Mutants of Fasciculin, a Peptidic Acetylcholinesterase Inhibitor from Mamba Venom* Pascale Marchot,Claudine N Prowse,Joan Kanter,Shelley Camp,Elizabeth J Ackermannet al. Journal of Biological Chemistry, 1997, 272 (6), pp.3502-3510 Article dans une revue hal-03262147v1
Structure of fasciculin 2 from green mamba snake venom: evidence for unusual loop flexibility Marie-Hélène Le Du,Pascale Marchot,D. Housset,P. Bougis,J. Navazaet al. Acta crystallographica Section D : Structural biology [1993-..], 1996, 52 (1), pp.87-92. ⟨10.1107/S0907444995007517⟩ Article dans une revue istex hal-03262107v1
Soluble monomeric acetylcholinesterase from mouse: Expression, purification, and crystallization in complex with fasciculin Pascale Marchot,Raimond B.G. Ravelli,Mia Raves,Yves Bourne,Daniel Vellomet al. Protein Science, 1996, 5 (4), pp.672-679. ⟨10.1002/pro.5560050411⟩ Article dans une revue hal-03262129v1
Afaacytin, an alphabeta-fibrinogenase from Cerastes cerastes (Horned Viper) Venom, Activates Purified Factor X and Induces Serotonin Release from Human Blood Platelets Fatirna Laraba-Djebari,Marie-France Martin-Eauclaire,Gerard Mauco,Pascale Marchot European Journal of Biochemistry, 1995, 233 (3), pp.756-765. ⟨10.1111/j.1432-1033.1995.756_3.x⟩ Article dans une revue hal-03261962v1
Theoretical analysis of the structure of the peptide fasciculin and its docking to acetylcholinesterase Harald van den Born,Zoran Radić,Pascale Marchot,Palmer Taylor,Igor Tsigelny Protein Science, 1995, 4 (4), pp.703-715. ⟨10.1002/pro.5560040410⟩ Article dans une revue hal-03261936v1
Acetylcholinesterase Inhibition by Fasciculin: Crystal Structure of the Complex Yves Bourne,Palmer Taylor,Pascale Marchot Cell, 1995, 83 (3), pp.503-512. ⟨10.1016/0092-8674(95)90128-0⟩ Article dans une revue hal-03262026v1
Structural bases for the specificity of cholinesterase catalysis and inhibition Palmer Taylor,Zoran Radic,Natilie Hosea,Shelley Camp,Pascale Marchotet al. Toxicology Letters, 1995, 82-83, pp.453-458. ⟨10.1016/0378-4274(95)03575-3⟩ Article dans une revue istex hal-03262048v1
Binding of 125I-fasciculin to rat brain acetylcholinesterase. The complex still binds diisopropyl fluorophosphate Pascale Marchot,Akila Khelif,Yong-Hua Ji,Pascal Mansuelle,Pierre E. Bougis Journal of Biological Chemistry, 1993, 268 (17), pp.12458-12467 Article dans une revue hal-03261921v1
1.9 A resolution structure of fasciculin 1, an anti-acetylcholinesterase toxin from green mamba snake venom Marie-Hélène Le Du,Pascale Marchot,Pierre E Bougis,Juan-Carlos Fontecilla-Camps Journal of Biological Chemistry, 1992, 267 (31), pp.22122-22130. ⟨10.2210/pdb1fas/pdb⟩ Article dans une revue hal-03261892v1
A fibrinogen-clotting serine proteinase from Cerastes cerastes (horned viper) venom with arginine-esterase and amidase activities. Purification, characterization and kinetic parameter determination Fatima Laraba-Djebari,Marie-France Martin-Eauclaire,Pascale Marchot Toxicon, 1992, 30 (11), pp.1399-1410. ⟨10.1016/0041-0101(92)90515-7⟩ Article dans une revue istex hal-03261910v1
Neurotoxicité chez la souris de portions riches en cystéines des protéines Tat du virus visna et de VIH-1 Isabelle Gourdou,Kamel Mabrouk,Gordon Harkiss,Pascale Marchot,Neil Wattet al. Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie, 1990, 311 (4), pp.149-55 Article dans une revue hal-03363668v1
Homologues of a K+ channel blocker α-dendrotoxin: characterization of synaptosomal binding sites and their coupling to elevation of cytosolic free calcium concentration Z.M. Muniz,G.R. Tibbs,Pascale Marchot,P. Bougis,D.G. Nichollset al. Neurochemistry International, 1990, 16 (1), pp.105-112. ⟨10.1016/0197-0186(90)90130-L⟩ Article dans une revue istex hal-03261848v1
Crystals of fasciculin 2 from green mamba snake venom. Preparation and preliminary x-ray analysis Marie Hélène Le Du,Pascale Marchot,Pierre E Bougis,Juan-C Fontecilla-Camps Journal of Biological Chemistry, 1989, 264 (35), pp.21401-21402. ⟨10.1016/S0021-9258(19)30094-8⟩ Article dans une revue hal-03261830v1
Selective distinction at equilibrium between the two alpha-neurotoxin binding sites of Torpedo acetylcholine receptor by microtitration Pascale Marchot,Paule Frachon,Pierre Bougis European Journal of Biochemistry, 1988, 174 (3), pp.537-542. ⟨10.1111/j.1432-1033.1988.tb14132.x⟩ Article dans une revue hal-03261788v1
Selective loss of binding sites for the iodinated alpha-neurotoxin I from Naja mossambica mossambica venom upon enzymatic deglycosylation of Torpedo electric organ membranes Saadia Zeghloul,Pascale Marchot,Pierre Bougis,Catherine Ronin European Journal of Biochemistry, 1988, 174 (3), pp.543-550. ⟨10.1111/j.1432-1033.1988.tb14133.x⟩ Article dans une revue hal-03261835v1
Localization of the toxic site of Naja mossambica cardiotoxins: small synthetic peptides express an in vivo lethality Pascale Marchot,P.E. Bougis,B. Ceard,J. van Rietschoten,H. Rochat Biochemical and Biophysical Research Communications, 1988, 153 (2), pp.642-647. ⟨10.1016/s0006-291x(88)81143-4⟩ Article dans une revue istex hal-03261771v1
In vivo synergy of cardiotoxin and phospholipase A2 from the elapid snake Naja mossambica mossambica Pierre E Bougis,Pascale Marchot,Hervé Rochat Toxicon, 1987, 25 (4), pp.427-431. ⟨10.1016/0041-0101(87)90076-6⟩ Article dans une revue istex hal-03261744v1
Monitoring the purification by high-performance liquid chromatography of cardiotoxins from Naja mossambica mossambica using phase-sensitive two-dimensional nuclear magnetic resonance Gottfried Otting,Pascale Marchot,Pierre E Bougis,Hervé Rochat,Kurt Wüthrich European Journal of Biochemistry, 1987, 168 (3), pp.603-607. ⟨10.1111/j.1432-1033.1987.tb13459.x⟩ Article dans une revue hal-03261768v1
Use of high performance liquid chromatography to demonstrate quantitative variation in components of venom from the scorpion Androctonus australis hector M.F Martin,Hervé Rochat,Pascale Marchot,Pierre E Bougis Toxicon, 1987, 25 (5), pp.569-573. ⟨10.1016/0041-0101(87)90293-5⟩ Article dans une revue istex hal-03261750v1
Characterization of elapidae snake venom components using optimized reverse-phase high-performance liquid chromatographic conditions and screening assays for alpha-neurotoxin and phospholipase A2 activities Pierre E Bougis,Pascale Marchot,Hervé Rochat Biochemistry, 1986, 25 (22), pp.7235-43. ⟨10.1021/bi00370a070⟩ Article dans une revue istex hal-03261741v1

Communication dans un congrès (6)

Is the cyclic imine core common to the marine macrocyclic toxins sufficient to dictate nicotinic acetylcholine receptor antagonism? Yves Bourne,Gerlind Sulzenbacher,Laurent Chabaud,Rómulo Aráoz,Zoran Radićet al. Report from the 29th Meeting on Toxinology, “Toxins: From the Wild to the Lab”, Organized by the French Society of Toxinology on 30 November–1 December 2023, SFET, Nov 2023, Paris, France. pp.147 (16-17), ⟨10.3390/toxins16030147⟩ Communication dans un congrès hal-04797916v1
Diversity in the binding interactions of nicotinic ligands to the nAChRs and associated conformational fluctuations − Insights into the core motif dictating antagonism Yves Bourne,Gerlind Sulzenbacher,Zoran Radić,Laurent Chabaud,Rómulo Aráozet al. RT26 – 26th Meeting of the French Society of Toxinology – Bioengineering of Toxins, French Society of Toxinology (SFET), Dec 2019, Paris, France Communication dans un congrès hal-04469851v1
Evolution of the first disulfide bond in the cholinesterase-carboxylesterase (coesterase) family: possible consequences for cholinesterase expression in prokaryotes Arnaud Chatonnet,Xavier Brazzolotto,Thierry Hotelier,Nicolas Lenfant,Pascale Marchot 13th International Meeting on Cholinesterases - 7th International Conference on Paraoxonases, Sep 2018, Hradec Kralove, Czech Republic. pp.55 Communication dans un congrès hal-03541521v1
Diversity in the binding interactions of marine phycotoxins to AChBP, the soluble nAChR surrogate Pascale Marchot,Gerlind Sulzenbacher,Zoran Radic,Rómulo Aráoz,Emmanuelle Reynaudet al. XVth International Symposium on Cholinergic Mechanisms, Oct 2017, Marseille, France. pp.196, ⟨10.1111/jnc.13925⟩ Communication dans un congrès hal-02334376v1
Tracking origin and divergence of Cholinesterases and Neuroligins Nicolas Lenfant,Thierry Hotelier,Yves Bourne,Pascale Marchot,Arnaud Chatonnet 14. International Symposium on Cholinergic Mechanisms, May 2013, Hangzhou, China. 1 p Communication dans un congrès hal-01837602v1
New friendly tools for users of ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins Ludovic Renault,Vincent Negre,Thierry Hotelier,Xavier Cousin,Pascale Marchotet al. 8. International Meeting on Cholinesterases, Sep 2004, Perugia, Italy. ⟨10.1016/j.cbi.2005.10.100⟩ Communication dans un congrès istex hal-02764503v1

Poster de conférence (8)

ESTHER: the database dedicated to the analysis of protein sequences within the superfamily of alpha/beta hydrolases and cholinesterase relatives (CHEPON2024, poster PO31) Arnaud Chatonnet,Zhou Yu,Nicolas Roche,Pascale Marchot CHEPON 2024 15th International Meeting on Cholinesterases 9th International Conference on Paraoxonases, Sep 2024, Brdo pri Kranju, Slovenia. Poster de conférence hal-04752374v1
Is the cyclic imine core common to the marine macrocyclic toxins sufficient to dictate nicotinic ACh receptor antagonism? (BSI 2023, Session &quot;Neurons&quot;, Poster P80) Yves Bourne,Gerlind Sulzenbacher,Laurent Chabaud,Rómulo Aráoz,Zoran Radićet al. BSI 2023 - 3rd edition of the Integrative Structural Biology Meeting, Nov 2023, Marseille, France. Poster de conférence hal-04752741v1
Is the cyclic imine core common to the marine macrocyclic toxins sufficient to dictate nicotinic acetylcholine receptor antagonism? (SFET RT29, Session “Toxin functional exploration”, Poster) Yves Bourne,Gerlind Sulzenbacher,Laurent Chabaud,Rómulo Aráoz,Zoran Radićet al. RT29 - 29èmes Rencontres de la Société Française pour l'Etude des Toxines (SFET) / 29th Meeting of the French Society of Toxinoogy (SFET), Nov 2023, Paris Institut Pasteur, France Poster de conférence hal-04752751v1
Hot spots for partnership at the surface of the cell-adhesion molecule neuroligin versus the enzyme acetylcholinesterase, two cousins in the same structural superfamily (FEBS2021, Poster) Pascale Marchot,Yves Bourne FEBS2021, Jul 2021, Ljubljana, Slovenia Poster de conférence hal-04799243v1
Diversity in the binding interactions of nicotinic ligands to the nAChRs and associated conformational fluctuations: Insights into the core motif dictating antagonism (JMC 2019, Poster) Yves Bourne,Gerlind Sulzenbacher,Zoran Radić,Laurent Chabaud,Rómulo Aráozet al. Canaux ioniques activés par les ligands: de la structure atomique à la transmission synaptique / Ligand-gated ion channels: from atomic structure to synaptic transmission, May 2019, Roscoff, France. , 2024 Poster de conférence hal-04771646v1
Diversity in the binding interactions of nicotinic ligands to the nAChRs and associated conformational fluctuations − Insights into the core motif dictating antagonism Yves Bourne,Gerlind Sulzenbacher,Zoran Radić,Laurent Chabaud,Rómulo Aráozet al. RT26 – 26th Meeting of the French Society of Toxinology – Bioengineering of Toxins, Dec 2019, Paris, France Poster de conférence hal-04471364v1
ESTHER database: update on the alpha/beta hydrolase fold superfamily of proteins Arnaud Chatonnet,Pascale Marchot,Yves Bourne,Nicolas Lenfant,Thierry Hotelier 15th International Symposium on Cholinergic Mechanisms (ISCM), Oct 2016, Marseille, France. Wiley-Blackwell, Journal of Neurochemistry, 142 (Supplément 2), 226 p., 2017, Journal of Neurochemistry Poster de conférence hal-01604848v1
Evolution of animal cholinesterases Nicolas Lenfant,Murray E. Selkirk,Thierry Hotelier,Yves Bourne,Pascale Marchotet al. 15th International Symposium on Cholinergic Mechanisms (ISCM), Oct 2016, Marseille, France. Wiley-Blackwell, Journal of Neurochemistry, 142 (Supplément 2), 226 p., 2017, Journal of Neurochemistry Poster de conférence hal-01602789v1

Ouvrages (5)

Advances and new technologies in Toxinology Julien Barbier,Evelyne Benoit,Pascale Marchot,César Mattei,Denis Servent SFET Publications, Gif-sur-Yvette, France, pp.186, 2010 Ouvrages hal-00738636v1
Toxins and Signalling Evelyne Benoit,Françoise Goudey-Perriere,Pascale Marchot,Denis Servent SFET Publications, Châtenay-Malabry, France, pp.204, 2009 Ouvrages hal-00738643v1
Toxines et fonctions cholinergiques neuronales et non neuronales Evelyne Benoit,Françoise Goudey-Perriere,Pascale Marchot,Denis Servent SFET Publications, Châtenay-Malabry, France, pp.160, 2008 Ouvrages hal-00738646v1
Toxines émergentes: nouveaux risques, (Coll. Rencontres en toxinologie) Françoise Goudey-Perriere,Evelyne Benoit,Pascale Marchot,Michel R Popoff F. Goudey-Perrière, E. Benoit, P. Marchot & MR Popoff (Eds.). Librairie Lavoisier, Paris, France, pp.208, 2007 Ouvrages hal-00204750v1
Toxines et cancer (Coll. Rencontres en Toxinologie) Françoise Goudey-Perriere,Evelyne Benoit,Max Goyffon,Pascale Marchot F. Goudey-Perrière, E. Benoit, M. Goyffon & P. Marchot (Eds.). Librairie Lavoisier, Paris, France, pp.326, 2006 Ouvrages hal-00203288v1

Chapitre d'ouvrage (5)

Utilisation des &quot; protéines liant l'acétylcholine &quot; (AChBP) en toxinologie structurale : nouveaux exemples Yves Bourne,Z. Radic,Tt Talley,S. Conrod,P. Tayloret al. Toxines et fonctions cholinergiques neuronales et non neuronales, SFET Publications, Châtenay-Malabry, France, pp.27-8, 2008, Collection Rencontres en Toxinologie Chapitre d'ouvrage hal-00738967v1
Crystal structure of mouse acetylcholinesterase Yves Bourne,P Taylor,J R Kanter,Pierre E Bougis,Pascale Marchot Doctor BP, Taylor P, Quinn DM, Rotundo RL, & Gentry MK, Eds. Structure and Function of Cholinesterases and Related Proteins, Plenum Publishing Corp, pp.315-322, 1998, 978-1-4899-1540-5 Chapitre d'ouvrage hal-03338905v1
Acetylcholinesterase, recombinant monomeric form (mouse) / fasciculin 2 (mamba) complex Yves Bourne,P Taylor,Pascale Marchot Macromolecular Structures, Hendrickson WA & Wüthrich K, Eds, pp.8-9, 1996, 978-9997819673 Chapitre d'ouvrage hal-03338882v1
Structural determinants of fasciculin specificity for acetylcholinesterase Pascale Marchot,Shelley Camp,Zoran Radić,Pierre E Bougis,Palmer Taylor Enzymes of the Cholinesterase Family, Plenum Publishing Corp, 1995, 978-1-4899-1051-6 Chapitre d'ouvrage hal-03338447v1
Fasciculin 1 (Green mamba) Marie-Hélène Le Du,Pascale Marchot,Pierre E Bougis,Juan Carlos Fontecilla-Camps Macromolecular Structures, Hendrickson WA & Wüthrich K, pp.152-153, 1993, 978-1859221884 Chapitre d'ouvrage hal-03338432v1

Pré-publication, Document de travail (1)

Syllabus for a Master's-level course on Animal Venomics Ronald Jenner,Gregor Anderluh,Agostinho Antunes,Figen Caliskan,Maik Dammet al. 2025 Pré-publication, Document de travail hal-05057958v1