Patrick Chames

Identifiants chercheurs

IdHAL :

patrick-chames

ORCID :

0000-0002-6104-6286

IdRef :

16514985X

ResearcherID :

http://www.researcherid.com/rid/R-1800-2016

Présentation

The main interest of our lab is to use antibody engineering solutions to generate innovative molecules able to efficiently modulate the anti-tumor immune response through the recruitment and activation of immune cells using multispecific cell engagers or multispecific immune checkpoint inhibitors, or through the vectorization of radionuclides and nanoparticles.

Our team has developed a solid expertise in the generation and use of nanobodies, corresponding to the variable domain of antibodies naturally devoid of light chain found in camelids, for cancer therapy and diagnostic using in vitro selection methods. We are exploring the possibilities offered by this technology for the development of innovative cancer imaging and therapy approaches.

Publications

Pré-publication, Document de travail (6)

A syndecan-based genetic approach to coat the surface of small extracellular vesicles with Nanobodies Lukas Hyka,Sofie Meeussen,Rania Ghossoub,Michiel de Coster,Elke de Bruyneet al. 2026 Pré-publication, Document de travail hal-05526712v1
Cell-Based Immunization Combined with Single-Round Cell Panning Enables Discovery of PSMA-Targeting Nanobodies from Phage Display Libraries Tong Yang,Joke Veldhoven-Zweistra,Maarten Ligtenberg,Sigrun Erkens,Mirella Vredenbregt-van den Berget al. 2025 Pré-publication, Document de travail hal-05370885v1
Identification and optimization of trans-species reactive TfR1-binding VHH as tools for drug delivery across the blood-brain barrier Marion David,Romy Cohen,Diane Beuzelin,Géraldine Ferracci,Marina Cresciet al. 2025 Pré-publication, Document de travail hal-05088982v1
Chronic potentiation of metabotropic glutamate receptor 2 with a nanobody accelerates amyloidogenesis in Alzheimer’s disease. Pierre-André Lafon,Mireille Elodie Tsitokana,Ugo Alenda,Clémentine Eva Philibert,Mathieu Oosterlakenet al. 2024 Pré-publication, Document de travail hal-04762110v1
Combining DNA scaffolds and acoustic force spectroscopy to characterize individual protein bonds Yong Jian Wang,Claire Valotteau,Adrien Aimard,Lorenzo Villanueva,Dorota Kostrzet al. 2022 Pré-publication, Document de travail hal-03861138v1
Engineering of ultra-small diagnostic nanoprobes through oriented conjugation of single-domain antibodies and quantum dots Igor Nabiev,Alyona Sukhanova,Klervi Even-Desrumeaux,Patrick Chames,Daniel Batyet al. 2021 Pré-publication, Document de travail hal-03182577v1

Article dans une revue (70)

Cell-Based Immunization Combined with Single-Round Cell Panning Enables Discovery of PSMA-Targeting Nanobodies from Phage Display Libraries Tong Yang,Joke Veldhoven-Zweistra,Maarten Ligtenberg,Sigrun Erkens,Mirella Vredenbregt-van Den Berget al. Biomolecules, 2026, 16 (2), pp.307. ⟨10.3390/biom16020307⟩ Article dans une revue hal-05515507v1
Protection against lethal canine distemper virus infection by a dual epitope-targeting synthetic antibody Melanie Scherer,Nadia Djabeur,Oliver Siering,Jean-Marc Jeckelmann,Marianne Wysset al. Nature Communications, 2026, 17 (1), pp.103. ⟨10.1038/s41467-025-67600-z⟩ Article dans une revue hal-05515511v1
Mesothelin biology and the evolving landscape of targeted immunotherapy Remy Boisgard,Patrick Chames,Brigitte Kerfelec Molecular Therapy: Oncology, 2026, 34 (1), pp.201148. ⟨10.1016/j.omton.2026.201148⟩ Article dans une revue hal-05530530v1
Quantitative Microscopy for Cell–Surface and Cell–Cell Interactions in Immunology Beatriz Díaz-Bello,Dalia El Arawi,Rémy Torro,Patrick Chames,Kheya Senguptaet al. Bio-protocol , 2025, 15 (1379), pp.e5427. ⟨10.21769/bioprotoc.5427⟩ Article dans une revue hal-05363758v1
Nanobody-enhanced T cell cancer immunotherapy: Advancing precision medicine Remy Boisgard,Juliette Prothon,Celia Torrielli,Patrick Chames,Brigitte Kerfelec Molecular Therapy, 2025, Online ahead of print. ⟨10.1016/j.ymthe.2025.10.043⟩ Article dans une revue hal-05363771v1
Nanobody therapy rescues behavioural deficits of NMDA receptor hypofunction Mathieu Oosterlaken,Angelina Rogliardo,Tatiana Lipina,Pierre-André Lafon,Mireille Elodie Tsitokanaet al. Nature, In press, 645 (8079), pp.262-270. ⟨10.1038/s41586-025-09265-8⟩ Article dans une revue hal-05213386v1
Selection and optimization strategy for Rap1-targeting single-domain antibodies as platelet activation markers Marie-Christine Alessi,Maxime Moulard,Daniele Boulay-Moine,Cyril Pons,Marielle Margieret al. Research and Practice in Thrombosis and Haemostasis, 2025, 10 (1), pp.103294. ⟨10.1016/j.rpth.2025.103294⟩ Article dans une revue hal-05515537v1
Celldetective: an AI-enhanced image analysis tool for unraveling dynamic cell interactions Rémy Torro,Beatriz Díaz-Bello,Dalia El Arawi,Ksenija Dervanova,Lorna Ammeret al. eLife, 2025, ⟨10.7554/eLife.105302.1⟩ Article dans une revue hal-05371772v1
Novel single-domain antibodies targeting a unique transferrin receptor 1 epitope for cross-species delivery of drugs in the central nervous system Marion David,Romy Cohen,Diane Beuzelin,Géraldine Ferracci,Marina Cresciet al. Journal of Controlled Release, 2025, 388, pp.114344. ⟨10.1016/j.jconrel.2025.114344⟩ Article dans une revue hal-05340484v1
Nanobody-based canine PD-L1-targeting immune checkpoint inhibitors for cancer therapy in dogs Morgane Di Palma Subran,Marianne Wyss,Betül Taskoparan,Mathischan Maheswaran,Johannes Vom Berget al. Molecular Therapy: Oncology, 2025, 33 (3), pp.201036. ⟨10.1016/j.omton.2025.201036⟩ Article dans une revue hal-05363743v1
Decoupling individual host response and immune cell engager cytotoxic potency Cristina Gonzalez Gutierrez,Adrien Aimard,Martine Biarnes-Pélicot,Brigitte Kerfelec,Pierre-Henri Puechet al. ACS Nano, 2025, 19 (2), pp.2089-2098. ⟨10.1021/acsnano.4c08541⟩ Article dans une revue hal-04778416v1
Functional targeting of Glypican-4 by a conformation-specific single-domain antibody Remi Bonjean,Rossana Cuciniello,Brigitte Kerfelec,Patrick Chames,Rosanna Dono Biomaterials, 2025, 328, pp.123864. ⟨10.1016/j.biomaterials.2025.123864⟩ Article dans une revue hal-05409215v1
Antigen density and applied force control enrichment of nanobody-expressing yeast cells in microfluidics Merlin Sanicas,Remy Torro,Laurent Limozin,Patrick Chames Lab on a Chip, 2024, Online ahead of print. ⟨10.1039/D4LC00011K⟩ Article dans une revue hal-04562911v2
Specific Targeting of Mesothelin-Expressing Malignant Cells Using Nanobody-Functionalized Magneto-Fluorescent Nanoassemblies Tina Briolay,Judith Fresquet,Damien Meyer,Brigitte Kerfelec,Patrick Chameset al. International Journal of Nanomedicine, 2024, 19, pp.633 - 650. ⟨10.2147/ijn.s435787⟩ Article dans une revue inserm-04465814v1
Combination of T cell-redirecting strategies with a bispecific antibody blocking TGF-β and PD-L1 enhances antitumor responses Antonio Tapia-Galisteo,Iñigo Sánchez-Rodríguez,Javier Narbona,Patricia Iglesias-Hernández,Saray Aragón-Garcíaet al. OncoImmunology, 2024, 13 (1), pp.2338558. ⟨10.1080/2162402X.2024.2338558⟩ Article dans une revue hal-04583762v1
Epitope Identification of an mGlu5 Receptor Nanobody Using Physics-Based Molecular Modeling and Deep Learning Techniques Floriane Eshak,Léo Pion,Pauline Scholler,Damien Nevoltris,Patrick Chameset al. Journal of Chemical Information and Modeling, 2024, 64 (11), pp.4436-4461. ⟨10.1021/acs.jcim.3c01620⟩ Article dans une revue hal-04723363v1
A single-domain antibody for the detection of pathological Tau protein in the early stages of oligomerization Nicolas de Leiris,Pascale Perret,Charlotte Lombardi,Bülent Gözel,Sabine Chiericiet al. Journal of Translational Medicine, 2024, 22 (1), pp.163. ⟨10.1186/s12967-024-04987-1⟩ Article dans une revue hal-04583802v1
Rapid nanobody-based imaging of mesothelin expressing malignancies compatible with blocking therapeutic antibodies Abdennour Benloucif,Damien Meyer,Laure Balasse,Armelle Goubard,Lucile Danneret al. Frontiers in Immunology, 2023, 14, pp.1200652. ⟨10.3389/fimmu.2023.1200652⟩ Article dans une revue hal-04259727v1
Tissue clearing and 3D reconstruction of digitized, serially sectioned slides provide novel insights into pancreatic cancer Ashley Kiemen,Alexander Ioannis Damanakis,Alicia M Braxton,Jin He,Daniel Laheruet al. Med, 2023, 4 (2), pp.75-91. ⟨10.1016/j.medj.2022.11.009⟩ Article dans une revue hal-04054727v1
Combining DNA scaffolds and acoustic force spectroscopy to characterize individual protein bonds Yong Jian Wang,Claire Valotteau,Adrien Aimard,Lorenzo Villanueva,Dorota Kostrzet al. Biophysical Journal, 2023, 122 (12), pp.2518-2530. ⟨10.1016/j.bpj.2023.05.004⟩ Article dans une revue hal-04165173v1
Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer Antonio Tapia-Galisteo,Íñigo Sánchez Rodríguez,Oscar Aguilar-Sopeña,Seandean Lykke Harwood,Javier Narbonaet al. OncoImmunology, 2022, 11, ⟨10.1080/2162402x.2022.2034355⟩ Article dans une revue hal-03745498v1
Nanobody-based sensors reveal a high proportion of mGlu heterodimers in the brain Jiyong Meng,Chanjuan Xu,Pierre-André Lafon,Salomé Roux,Michaël Mathieuet al. Nature Chemical Biology, 2022, 18, pp.894-903. ⟨10.1038/s41589-022-01050-2⟩ Article dans une revue hal-03699580v1
A nanobody activating metabotropic glutamate receptor 4 discriminates between homo- and heterodimers Jordi Haubrich,Joan Font,Robert Quast,Anne Goupil-Lamy,Pauline Scholleret al. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (33), pp.e2105848118. ⟨10.1073/pnas.2105848118⟩ Article dans une revue hal-03322348v1
Special Issue: Nanobody Patrick Chames,Ulrich Rothbauer Antibodies, 2020, 9 (1), pp.6. ⟨10.3390/antib9010006⟩ Article dans une revue hal-03017191v1
Anti-NKG2D single domain-based antibodies for the modulation of anti-tumor immune response Adeline Raynaud,Klervi Desrumeaux,Laurent Vidard,Elise Termine,Daniel Batyet al. OncoImmunology, 2020, 10, ⟨10.1080/2162402x.2020.1854529⟩ Article dans une revue hal-03371613v1
A Novel Anti-Kv10.1 Nanobody Fused to Single-Chain TRAIL Enhances Apoptosis Induction in Cancer Cells Franziska Hartung,Thomas Krüwel,Xiaoyi Shi,Klaus Pfizenmaier,Roland Kontermannet al. Frontiers in Pharmacology, 2020, 11, ⟨10.3389/fphar.2020.00686⟩ Article dans une revue hal-03017218v1
Nanobody-CD16 Catch Bond Reveals NK Cell Mechanosensitivity Cristina González,Patrick Chames,Brigitte Kerfelec,Daniel Baty,Philippe Robertet al. Biophysical Journal, 2019, 116 (8), pp.1516-1526. ⟨10.1016/j.bpj.2019.03.012⟩ Article dans une revue hal-02323625v1
A Bispecific Antibody-Based Approach for Targeting Mesothelin in Triple Negative Breast Cancer Joanie del Bano,Rémy Florès-Florès,Emmanuelle Josselin,Armelle Goubard,Laëtitia Ganieret al. Frontiers in Immunology, 2019, 10, pp.1593. ⟨10.3389/fimmu.2019.01593⟩ Article dans une revue hal-02520930v1
Nanobody Engineering: Toward Next Generation Immunotherapies and Immunoimaging of Cancer Timothée Chanier,Patrick Chames Antibodies, 2019, 8 (1), pp.13. ⟨10.3390/antib8010013⟩ Article dans une revue hal-02002577v1
Les anticorps et scaffold bispécifiques, des médicaments innovants en oncologie impliquant le ciblage des cellules immunitaires Patrick Chames,Thierry Wurch Médecine/Sciences, 2019, 35 (12), pp.1072-1082. ⟨10.1051/medsci/2019242⟩ Article dans une revue hal-03017227v1
Nanophotonic tools based on the conjugates of nanoparticles with the single-domain antibodies for multi-photon micrometastases detection and ultrasensitive biochemical assays Alyona Sukhanova,Fernanda Ramos-Gomes,Patrick Chames,Daniel Baty,Frauke Alveset al. Proceedings of SPIE, the International Society for Optical Engineering, 2019, pp.112072A. ⟨10.1117/12.2530233⟩ Article dans une revue hal-03007502v1
Advanced Nanotools for Imaging of Solid Tumors and Circulating and Disseminated Cancer Cells D. Baty,I. Nabiev,A. Sukhanova,F. Ramos-Gomes,F. Alveset al. Optics and Spectroscopy, 2018, 125 (5), pp.703-707. ⟨10.1134/S0030400X18110309⟩ Article dans une revue hal-02143643v1
Single- and two-photon imaging of human micrometastases and disseminated tumour cells with conjugates of nanobodies and quantum dots Fernanda Ramos-Gomes,Julia Bode,Alyona Sukhanova,Svetlana V Bozrova,Mara Saccomanoet al. Scientific Reports, 2018, 8 (1), pp.4595. ⟨10.1038/s41598-018-22973-8⟩ Article dans une revue hal-01765351v1
Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation Pauline Scholler,Damien Nevoltris,Dimitri de Bundel,Simon Bossi,David Moreno-Delgadoet al. Nature Communications, 2017, 8 (1), pp.1967. ⟨10.1038/s41467-017-01489-1⟩ Article dans une revue hal-01672805v2
Multiphoton Imaging of Tumor Biomarkers in situ Using Single-domain Antibodies Conjugated with Quantum Dots in a Set Orientation Alyona Sukhanova,Hilal Hafian,Marc Turini,Patrick Chames,Daniel Batyet al. Materials Today: Proceedings, 2016, 3 (2), pp.523-526. ⟨10.1016/j.matpr.2016.01.084⟩ Article dans une revue hal-03112311v1
Nanosized Fluorescent Diagnostic Probes Consisting of Single-domain Antibodies Conjugated with Quantum Dots Alyona Sukhanova,Klervi Even-Desrumeaux,Jean-Marc Millot,Patrick Chames,Daniel Batyet al. Materials Today: Proceedings, 2016, 3 (2), pp.518-522. ⟨10.1016/j.matpr.2016.01.083⟩ Article dans une revue hal-03112307v1
V1/V2 Neutralizing Epitope is Conserved in Divergent Non-M Groups of HIV-1 Marion Morgand,Mélanie Bouvin-Pley,Jean-Christophe Plantier,Moreau Alain,Elodie Alessandriet al. Journal of Acquired Immune Deficiency Syndromes - JAIDS, 2016, 71 (3), pp.237-245. ⟨10.1097/QAI.0000000000000854⟩ Article dans une revue hal-01314296v1
In vivo detection of small tumour lesions by multi-pinhole SPECT applying a (99m)Tc-labelled nanobody targeting the Epidermal Growth Factor Receptor Thomas Krüwel,Damien Nevoltris,Julia Bode,Christian Dullin,Daniel Batyet al. Scientific Reports, 2016, 6, pp.21834. ⟨10.1038/srep21834⟩ Article dans une revue hal-01450793v1
Taking up Cancer Immunotherapy Challenges: Bispecific Antibodies, the Path Forward? Joanie del Bano,Patrick Chames,Daniel Baty,Brigitte Kerfelec Antibodies, 2016, 5 (1), ⟨10.3390/antib5010001⟩ Article dans une revue hal-01450799v1
Conformational nanobodies reveal tethered epidermal growth factor receptor involved in EGFR/ErbB2 predimers. Damien Nevoltris,Benjamin Lombard,Elodie Dupuis,Gérard Mathis,Patrick Chameset al. ACS Nano, 2015, 9 (2), pp.1388-99. ⟨10.1021/nn505752u⟩ Article dans une revue hal-01450765v1
Oriented Conjugates of Single-domain Antibodies and Fluorescent Quantum Dots for Highly Sensitive Detection of Tumor-associated Biomarkers in Cells and Tissues Regina Bilan,Kristina Brazhnik,Patrick Chames,Daniel Baty,Igor Nabievet al. Physics Procedia, 2015, 73, pp.228-234. ⟨10.1016/j.phpro.2015.09.162⟩ Article dans une revue hal-03112376v1
Detection of carcinoembryonic antigen using single-domain or full-size antibodies stained with quantum dot conjugates. Gilles Rousserie,Regina Grinevich,Kristina Brazhnik,Klervi Even-Desrumeaux,Brigitte Reveilet al. Analytical Biochemistry, 2015, 478, pp.26-32. ⟨10.1016/j.ab.2015.02.029⟩ Article dans une revue hal-01450782v1
Anti-Mesothelin Nanobodies for Both Conventional and Nanoparticle-Based Biomedical Applications. Andrew M Prantner,Marc Turini,Brigitte Kerfelec,Shree Joshi,Daniel Batyet al. Journal of Biomedical Nanotechnology, 2015, pp.1201-12 Article dans une revue hal-01450786v1
Highly Sensitive Single Domain Antibody–Quantum Dot Conjugates for Detection of HER2 Biomarker in Lung and Breast Cancer Cells Tatsiana Rakovich,Omar Mahfoud,Bashir Mohamed,Adriele Prina-Mello,Kieran Crosbie-Stauntonet al. ACS Nano, 2014, 8 (6), pp.5682-5695. ⟨10.1021/nn500212h⟩ Article dans une revue hal-03136167v1
Selection of Intracellular Single-Domain Antibodies Targeting the HIV-1 Vpr Protein by Cytoplasmic Yeast Two-Hybrid System Julie Matz,Cécile Hérate,Jérôme Bouchet,Nelson Dusetti,Odile Gayetet al. PLoS ONE, 2014, 9 (12), pp.e113729. ⟨10.1371/journal.pone.0113729⟩ Article dans une revue inserm-01093997v1
Masked Selection: A Straightforward and Flexible Approach for the Selection of Binders Against Specific Epitopes and Differentially Expressed Proteins by Phage Display Klervi Even-Desrumeaux,Damien Nevoltris,Marie Noelle Lavaut,Karima Alim,Jean-Paul Borget al. Molecular and Cellular Proteomics, 2014, 13 (2), pp.653-665. ⟨10.1074/mcp.O112.025486⟩ Article dans une revue hal-02115444v1
Multiphoton imaging of tumor biomarkers with conjugates of single-domain antibodies and quantum dots Hilal Hafian,Alyona Sukhanova,Marc Turini,Patrick Chames,Daniel Batyet al. Nanomedicine: Nanotechnology, Biology and Medicine, 2014, 10 (8), pp.1701-1709. ⟨10.1016/j.nano.2014.05.014⟩ Article dans une revue hal-03136281v1
A FcγRIII-engaging bispecific antibody expands the range of HER2-expressing breast tumors eligible to antibody therapy Marc Turini,Patrick Chames,Pierre Bruhns,Daniel Baty,Brigitte Kerfelec Oncotarget, 2014, 5 (14), ⟨10.18632/oncotarget.2093⟩ Article dans une revue hal-02115462v1
Detection of carcinoembryonic antigen on colon cancer cells using single-domain antibodies and quantum dots R. Grinevich,G. Rousserie,K. Brazhnik,R. Even-Desrumeaux,B. Reveilet al. Acta Naturae, 2014, Abstr. Conf. Science of the Future, St. Petersburg, 17-20 Sep 2014, Special issue, pp.76 Article dans une revue hal-03136098v1
Single-Domain Antibody-Based and Linker-Free Bispecific Antibodies Targeting Fc RIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells C. Rozan,A. Cornillon,C. Petiard,M. Chartier,G. Beharet al. Molecular Cancer Therapeutics, 2013, 12 (8), pp.1481-1491. ⟨10.1158/1535-7163.MCT-12-1012⟩ Article dans une revue hal-02115468v1
Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites P. Acharya,T. Luongo,I. Georgiev,J. Matz,S. Schmidtet al. Journal of Virology, 2013, 87 (18), pp.10173-10181. ⟨10.1128/JVI.01332-13⟩ Article dans une revue hal-02530765v1
Single-domain antibody-based and linker-free bispecific antibodies targeting FcγRIII induce potent antitumor activity without recruiting regulatory T cells. Caroline Rozan,Amélie Cornillon,Corinne Petiard,M. Chartier,G. Beharet al. Molecular Cancer Therapeutics, 2013, 12 (8), pp.1481-1491. ⟨10.1158/1535-7163.MCT-12-1012⟩ Article dans une revue hal-02454959v1
Oriented conjugates of monoclonal and single-domain antibodies with quantum dots for flow cytometry and immunohistochemistry diagnostic applications Alyona Sukhanova,Klervi Even-Desrumeaux,Jean-Marc Millot,Patrick Chames,Daniel Batyet al. Proceedings of SPIE, the International Society for Optical Engineering, 2012, Colloidal Nanocrystals for Biomedical Applications VII, 8232, pp.82320T. ⟨10.1117/12.905896⟩ Article dans une revue hal-03184792v1
Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and co-receptor binding sites of HIV-1 gp120 Julie Matz,Pacal Kessler,Jérome Bouchet,Olivier Combes,Daniel Batyet al. Retrovirology, 2012, 9 (Suppl 2), pp.P214 Article dans une revue inserm-00731772v1
Structural definition of a novel CD4-induced epitope that is targeted by a single-headed immunoglobulin to effect broad and potent HIV neutralization Priyamvada Acharya,Timothy S. Luongo,Julie Matz,Stephen D. Schmidt,Gwo-Yu Chuanget al. Retrovirology, 2012, 9 (Suppl 2), pp.P346 Article dans une revue inserm-00731776v1
Oriented conjugates of single-domain antibodies and quantum dots: toward a new generation of ultrasmall diagnostic nanoprobes Alyona Sukhanova,Klervi Even-Desrumeaux,Aymric Kisserli,Thierry Tabary,Brigitte Reveilet al. Nanomedicine: Nanotechnology, Biology and Medicine, 2012, 8 (4), pp.516-525. ⟨10.1016/j.nano.2011.07.007⟩ Article dans une revue istex hal-03184846v1
Single-domain antibodies: a versatile and rich source of binders for breast cancer diagnostic approaches. Klervi Even-Desrumeaux,Patrick Fourquet,Véronique Secq,Daniel Baty,Patrick Chames Molecular BioSystems, 2012, 8 (9), pp.2385-2394. ⟨10.1039/c2mb25063b⟩ Article dans une revue inserm-00722930v1
Bi-photon imaging and diagnostics using ultra-small diagnostic probes engineered from semiconductor nanocrystals and single-domain antibodies Hilal Hafian,Alyona Sukhanova,Patrick Chames,Daniel Baty,Michel Pluotet al. Proceedings of SPIE, the International Society for Optical Engineering, 2012, Nanosystems in Engineering and Medicine, 8548, pp.85480R. ⟨10.1117/12.960493⟩ Article dans une revue hal-03177842v1
Straightforward Selection of Broadly Neutralizing Single-Domain Antibodies Targeting the Conserved CD4 and Coreceptor Binding Sites of HIV-1 gp120 J. Matz,P. Kessler,J. Bouchet,O. Combes,O. Ramoset al. Journal of Virology, 2012, 87 (2), pp.1137-1149. ⟨10.1128/JVI.00461-12⟩ Article dans une revue cea-02530610v1
Single-Domain Antibody-SH3 Fusions for Efficient Neutralization of HIV-1 Nef Functions Jérôme Bouchet,Cécile Hérate,Carolin Guenzel,Christel Vérollet,Annika Järviluomaet al. Journal of Virology, 2012, 86 (9), pp.4856-4867. ⟨10.1128/JVI.06329-11⟩ Article dans une revue hal-04958842v1
Strong and oriented immobilization of single domain antibodies from crude bacterial lysates for high-throughput compatible cost-effective antibody array generation. Klervi Even-Desrumeaux,Daniel Baty,Patrick Chames Molecular BioSystems, 2010, 6 (11), pp.2241-8. ⟨10.1039/c005279e⟩ Article dans une revue inserm-00521371v1
Therapeutic antibodies for the treatment of pancreatic cancer. Patrick Chames,Brigitte Kerfelec,Daniel Baty TheScientificWorldJournal, 2010, 10, pp.1107-20. ⟨10.1100/tsw.2010.103⟩ Article dans une revue inserm-00497886v1
Therapeutic Antibodies for the Treatment of Pancreatic Cancer Patrick Chames,Brigitte Kerfelec,Daniel Baty The Scientific World Journal, 2010, 10, pp.1107-1120. ⟨10.1100/tsw.2010.103⟩ Article dans une revue hal-02115485v1
Semiconductor quantum dots for multiplexed bio-detection on solid-state microarrays. G. Rousserie,A. Sukhanova,K. Even-Desrumeaux,F. Fleury,P. Chameset al. Critical Reviews in Oncology/Hematology, 2009, 00 (00), pp.00 Article dans une revue hal-00415311v1
Bispecific antibodies for cancer therapy: the light at the end of the tunnel? Patrick Chames,Daniel Baty mAbs, 2009, 1 (6), pp.539-47 Article dans une revue inserm-00448211v1
Llama single-domain antibodies directed against nonconventional epitopes of tumor-associated carcinoembryonic antigen absent from nonspecific cross-reacting antigen. Ghislaine Behar,Patrick Chames,Isabelle Teulon,Amélie Cornillon,Faisal Alshoukret al. FEBS Journal, 2009, 276 (14), pp.3881-93. ⟨10.1111/j.1742-4658.2009.07101.x⟩ Article dans une revue hal-00420547v1
[The future of antibody fragments, made of a single immunoglobulin domain.] Patrick Chames,Daniel Baty Médecine/Sciences, 2009, 25 (12), pp.1159-62 Article dans une revue inserm-00443810v1
Isolation and characterization of anti-Fc{gamma}RIII (CD16) llama single-domain antibodies that activate natural killer cells. Ghislaine Behar,Sophie Sibéril,Agnès Groulet,Patrick Chames,Martine Pugnièreet al. Protein Engineering, Design and Selection, 2008, 21 (1), pp.1-10. ⟨10.1093/protein/gzm064⟩ Article dans une revue hal-00258940v1
Isolation and characterization of anti-FcgRIII (CD16) llama single-domain antibodies that activate natural killer cells Ghislaine Béhar,Sophie Sibéril,Agnès Groulet,Patrick Chames,Martine Pugnièreet al. Protein Engineering, Design and Selection, 2007, 21 (1), pp.1-10. ⟨10.1093/protein/gzm064⟩ Article dans une revue hal-02454965v1
Intracellular Immunization of Prokaryotic Cells against a Bacteriotoxin Patrick Chames,Jacques Fieschi,Daniel Baty,Denis Duché Journal of Bacteriology, 1998, 180 (3), pp.514-518. ⟨10.1128/JB.180.3.514-518.1998⟩ Article dans une revue hal-03269515v1

Brevet (4)

Anti-mGluR2 biparatopic nanobodies and uses thereof Jean-Philippe Pin,Philippe Rondard,Patrick Chames,Julie Kniazeff,Mathieu Oosterlakenet al. France, N° de brevet: WO2024003389A1. 2023 Brevet hal-04875743v1
Nanobodies dirigées contre la protéine G alpha Thomas Roux,Elodie Dupuis,Eric Trinquet,Mélanie da Silva,Patrick Chameset al. France, N° de brevet: FR3084365B1. 2020 Brevet hal-04875831v1
CUSTOM-MADE MEGANUCLEASE AND USE THEREOF Sylvia Bruneau,Sylvain Arnould,Jean-Pierre Cabaniols,Patrick Chames,André Choulikaet al. France, Patent n° : WO2004067736. 2004 Brevet hal-05033599v1
WO2004067753 - USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF. Sylvia Bruneau,Sylvain Arnould,Jean-Pierre Cabaniols,Patrick Chames,André Choulikaet al. France, Patent n° : WO2004067753. 2004, https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2004067753 Brevet hal-05033575v1

Chapitre d'ouvrage (2)

Multiphoton Deep-Tissue Imaging of Micrometastases and Disseminated Cancer Cells Using Conjugates of Quantum Dots and Single-Domain Antibodies Alyona Sukhanova,Fernanda Ramos-Gomes,Patrick Chames,Pavel Sokolov,Daniel Batyet al. Methods in Molecular Biology, 2350, Springer US, pp.105-123, 2021, Multiplexed Imaging, ⟨10.1007/978-1-0716-1593-5_8⟩ Chapitre d'ouvrage hal-03500875v1
Phage Display and Selections on Purified Antigens Magali Colazet,Patrick Chames Methods in Molecular Biology, 1827, pp.165-178, 2018, ⟨10.1007/978-1-4939-8648-4_9⟩ Chapitre d'ouvrage hal-02146005v1

Communication dans un congrès (3)

Nanophotonic tools based on the conjugates of nanoparticles with the single-domain antibodies for multi-photon micrometastases detection and ultrasensitive biochemical assays Alyona Sukhanova,Fernanda Ramos-Gomes,Patrick Chames,Daniel Baty,Frauke Alveset al. IV International Conference on Applications of Optics and Photonics, May 2019, Lisbon, France. pp.186, ⟨10.1117/12.2530233⟩ Communication dans un congrès hal-03017208v1
Single-photon and two-photon tumor imaging and diagnosis using oriented conjugates of single-domain antibodies and quantum dots. A. Sukhanova,I. Nabiev,H. Hafian,M. Pluot,J.H.M. Cohenet al. Physics, Chemistry And Applications Of Nanostructures - Proceedings Of The International Conference Nanomeeting - 2015, 2015, Minsk, Belarus. pp.O-31, 495-498 Communication dans un congrès hal-03134832v1
Multiphoton imaging of tumor biomarkers in situ using highly oriented conjugates of single-domain antibodies and quantum dots Alyona Sukhanova,Hilal Hafian,Michel Pluot,Jacques Cohen,Jean-Marc Millotet al. 2015 International Conference on Biomedical Engineering and Computational Technologies (SIBIRCON), Oct 2015, Novosibirsk, France. pp.119-121, ⟨10.1109/SIBIRCON.2015.7361864⟩ Communication dans un congrès hal-03112342v1