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Patrick Midoux

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mRNA Lipoplexes with Cationic and Ionizable α-Amino-lipophosphonates: Membrane Fusion, Transfection, mRNA Translation and Conformation

Sohail Akhter , Mathieu Berchel , Paul-Alain Jaffrès , Chantal Pichon , Patrick Midoux et al.
Pharmaceutics, 2022, 14 (3), pp.581. ⟨10.3390/pharmaceutics14030581⟩
Journal articles hal-03927316v1

Tuneable thermal properties of PTHF-based copolymers by incorporation of epoxide units

Pauline Le Bellec , Patrick Midoux , Hervé Cheradame , Véronique Bennevault , Philippe Guégan et al.
European Polymer Journal, 2022, 168, pp.111096. ⟨10.1016/j.eurpolymj.2022.111096⟩
Journal articles hal-03927816v1
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Intracellular Routing and Recognition of Lipid-Based mRNA Nanoparticles

Christophe Delehedde , Luc Even , Patrick Midoux , Chantal Pichon , Federico Perche et al.
Pharmaceutics, 2021, 13 (7), pp.945. ⟨10.3390/pharmaceutics13070945⟩
Journal articles hal-03335664v1
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LentiRILES, a miRNA-ON Sensor System for Monitoring the Functionality of miRNA in Cancer Biology and Therapy

Viorel Simion , Claire Loussouarn , Yoan Laurent , Loris Roncali , David Gosset et al.
RNA Biology/RNA Biol., 2021, Online ahead of print. ⟨10.1080/15476286.2021.1978202⟩
Journal articles inserm-03374619v1
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Periodic Mesoporous Organosilica Nanoparticles with BOC Group, towards HIFU Responsive Agents

Hao Li , Carolina Gascó , Anthony Delalande , Clarence Charnay , Laurence Raehm et al.
Molecules, 2020, 25 (4), pp.974. ⟨10.3390/molecules25040974⟩
Journal articles hal-02544155v1
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Comparative binding and uptake of liposomes decorated with mannose oligosaccharides by cells expressing the mannose receptor or DC-SIGN

Haifei Gao , Cristine Goncalves , Téo Gallego , Marc Francois-Heude , Virginie Malard et al.
Carbohydrate Research, 2020, 487, pp.107877. ⟨10.1016/j.carres.2019.107877⟩
Journal articles hal-02522179v1

Gene transfer to skeletal muscle using hydrodynamic limb vein injection: current applications, hurdles and possible optimizations

Yann Thierry Le Guen , Tony Le Gall , Patrick Midoux , Philippe Guégan , Serge Braun et al.
The Journal of Gene Medicine, 2020, 22 (2), ⟨10.1002/jgm.3150⟩
Journal articles hal-03668402v1
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Intracellular trafficking and functional monitoring of miRNA delivery in glioblastoma using lipopolyplexes and the miRNA-ON RILES reporter system

Viorel Simion , Elodie Henriet , Viktorija Juric , Ruth Aquino , Claire Loussouarn et al.
Journal of Controlled Release, 2020, 327, pp.429-443. ⟨10.1016/j.jconrel.2020.08.028⟩
Journal articles hal-02959393v1
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Controlled star poly(2-oxazoline)s: Synthesis, characterization

Laetitia Plet , Gwendoline Delecourt , Mohamed Hanafi , Nadège Pantoustier , Gaelle Pembouong et al.
European Polymer Journal, 2020, 122, pp.109323. ⟨10.1016/j.eurpolymj.2019.109323⟩
Journal articles hal-02541990v1
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Co-delivery of NS1 and BMP2 mRNAs to murine pluripotent stem cells leads to enhanced BMP-2 expression and osteogenic differentiation

Pinpin Wang , Delphine Logeart-Avramoglou , Hervé Petite , Cristine Gonçalves , Patrick Midoux et al.
Acta Biomaterialia, 2020, 108, pp.337-346. ⟨10.1016/j.actbio.2020.03.045⟩
Journal articles hal-02553030v1
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Temperature‐Sensitive Amphiphilic Non‐Ionic Triblock Copolymers for Enhanced In Vivo Skeletal Muscle Transfection

Bazoly Rasolonjatovo , Nicolas Illy , Véronique Bennevault , Jérôme Mathé , Patrick Midoux et al.
Macromolecular Bioscience, 2020, 20 (3), pp.1900276. ⟨10.1002/mabi.201900276⟩
Journal articles hal-02451051v1
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Amino-acid functionalized porous silicon nanoparticles for the delivery of pDNA

Arnaud Chaix , Eduardo Cueto-Diaz , Anthony Delalande , Nikola Knezevic , Patrick Midoux et al.
RSC Advances, 2019, 9 (55), pp.31895-31899. ⟨10.1039/c9ra05461h⟩
Journal articles hal-02338857v1
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Improved histidinylated lPEI polyplexes for skeletal muscle cells transfection

Jean-Pierre Gomez , Guillaume Tresset , Chantal Pichon , Patrick Midoux
International Journal of Pharmaceutics, 2019, 559, pp.58-67. ⟨10.1016/j.ijpharm.2019.01.003⟩
Journal articles hal-02067297v1

Preclinical evaluation of mRNA trimannosylated lipopolyplexes as therapeutic cancer vaccines targeting dendritic cells

A. Le Moignic , V. Malard , T. Benvegnu , L. Lemiègre , Mathieu Berchel et al.
Journal of Controlled Release, 2018, 278, pp.110 - 121. ⟨10.1016/j.jconrel.2018.03.035⟩
Journal articles hal-01774851v1
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Group quenching and galactic conformity at low redshift

M. Treyer , K. Kraljic , S. Arnouts , S. de La Torre , C. Pichon et al.
Monthly Notices of the Royal Astronomical Society, 2018, 477 (2), pp.2684-2704. ⟨10.1093/mnras/sty769⟩
Journal articles hal-01876752v1
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Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety

Kevin van Der Jeught , Stefaan de Koker , Lukasz Bialkowski , Carlo Heirman , Patrick Tjok Joe et al.
ACS Nano, 2018, 12 (10), pp.9815-9829. ⟨10.1021/acsnano.8b00966⟩
Journal articles hal-01889829v1

Poly( N -methylvinylamine)-based copolymers for improved gene transfection

Mathilde Dréan , Antoine Debuigne , Christine Jérôme , Cristine Gonçalves , Patrick Midoux et al.
Macromolecular Bioscience, 2018, 18 (4), pp.1700353. ⟨10.1002/mabi.201700353⟩
Journal articles hal-01966107v1

Bile Salt Stabilized Vesicles (Bilosomes): A Novel Nano-Pharmaceutical Design for Oral Delivery of Proteins and Peptides

Javed Ahmad , Madhur Singhal , Saima Amin , Md. Rizwanullah , Sohail Akhter et al.
Current Pharmaceutical Design, 2017, 23 (11), pp.1575 - 1588. ⟨10.2174/1381612823666170124111142⟩
Journal articles hal-01656515v1

Nanoporous metal organic frameworks as hybrid polymer–metal composites for drug delivery and biomedical applications

Sarwar Beg , Mahfoozur Rahman , Atul Jain , Sumant Saini , Patrick Midoux et al.
Drug Discovery Today Biosilico, 2017, 22 (4), pp.625-637. ⟨10.1016/j.drudis.2016.10.001⟩
Journal articles hal-02068701v1

Effect of IL-1β, TNF-α and IGF-1 on trans-endothelial passage of synthetic vectors through an in vitro vascular endothelial barrier of striated muscle

Jean-Pierre Gomez , Cristine Gonçalves , Chantal Pichon , Patrick Midoux
Gene Therapy, 2017, 24 (7), pp.416 - 424. ⟨10.1038/gt.2017.40⟩
Journal articles hal-01618260v1
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Use of Primary and Secondary Polyvinylamines for Efficient Gene Transfection

Mathilde Dréan , Antoine Debuigne , Cristine Gonçalves , Christine Jérôme , Patrick Midoux et al.
Biomacromolecules, 2017, 18 (2), pp.440-451. ⟨10.1021/acs.biomac.6b01526⟩
Journal articles hal-01427315v1

Production of DNA minicircles less than 250 base pairs through a novel concentrated DNA circularization assay enabling minicircle design with NF-κB inhibition activity

Thomas Thibault , Jéril Degrouard , Patrick Baril , Chantal Pichon , Patrick Midoux et al.
Nucleic Acids Research, 2017, 45 (5), pp.e26 - e26. ⟨10.1093/nar/gkw1034⟩
Journal articles hal-01618796v1

Synthesis of α-amino-lipophosphonates as cationic lipids or co-lipids for DNA transfection in dendritic cells

Mathieu Berchel , Sohail Akhter , Wilfried Berthe , Cristine Gonçalvez , Marine Dubuisson et al.
Journal of materials chemistry‎ B, 2017, J. Mater. Chem. B, 5, pp.6869-6881. ⟨10.1039/C7TB01080J⟩
Journal articles hal-01551638v1
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Cationic gas-filled microbubbles for ultrasound-based nucleic acids delivery

Anthony Delalande , Colette Bastié , Lucie Pigeon , Simona Manta , Matthias Lebertre et al.
Bioscience Reports, 2017, 37 (6), pp.BSR20160619. ⟨10.1042/BSR20160619⟩
Journal articles hal-02123147v1

Nanotechnology Based Theranostic Approaches in Alzheimer's Disease Management: Current Status and Future Perspective

Javed Ahmad , Sohail Akhter , Md. Rizwanullah , Mohammad Ahmed Khan , Lucie Pigeon et al.
Current Alzheimer Research, 2017, 14 (11), pp.1164-1181. ⟨10.2174/1567205014666170508121031⟩
Journal articles hal-02068674v1

Peptides mediating DNA transport on microtubules and their impact on non-viral gene transfer efficiency

Patrick Midoux , Lucie Pigeon , Cristine Goncalves , Chantal Pichon
Bioscience Reports, 2017, 37 (5), pp.BSR20170995. ⟨10.1042/BSR20170995⟩
Journal articles hal-02068759v1
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Cationic microbubbles and antibiotic-free miniplasmid for sustained ultrasound–mediated transgene expression in liver

Simona Manta , Gilles Renault , Anthony Delalande , Olivier Couture , Isabelle Lagoutte et al.
Journal of Controlled Release, 2017, 262, pp.170 - 181. ⟨10.1016/j.jconrel.2017.07.015⟩
Journal articles hal-01656574v1
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Curcumin/poly(2-methyl-2-oxazoline-b-tetrahydrofuran-b-2-methyl-2-oxazoline) formulation: An improved penetration and biological effect of curcumin in F508del-CFTR cell lines

Cristine Gonçalves , Pierre Gomez , William Même , Bazoly Rasolonjatovo , David Gosset et al.
European Journal of Pharmaceutics and Biopharmaceutics, 2017, 117, pp.168-181. ⟨10.1016/j.ejpb.2017.04.015⟩
Journal articles hal-01618274v1

Toxicity of Inorganic Nanoparticles Used in Targeted Drug Delivery and Other Biomedical Application: An Updated Account on Concern of Biomedical Nanotoxicology

Mohammad Zaki Ahmad , Basel Abdel-Wahab , Afroze Alam , Sobiya Zafar , Javed Ahmad et al.
Journal of Nanoscience and Nanotechnology, 2016, 16 (8), pp.7873-7897. ⟨10.1166/jnn.2016.13032⟩
Journal articles hal-02519256v1

Intracellular Availability of pDNA and mRNA after Transfection: A Comparative Study among Polyplexes, Lipoplexes, and Lipopolyplexes

Cristine Goncalves , Sohail Akhter , Chantal Pichon , Patrick Midoux
Molecular Pharmaceutics, 2016, 13 (9), pp.3153-3163. ⟨10.1021/acs.molpharmaceut.6b00376⟩
Journal articles hal-02069071v1

The promise of gene therapy for pancreatic cancer

Georges Vassaux , Assia Angelova , Patrick Baril , Patrick Midoux , Jean Rommelaere et al.
Human Gene Therapy, 2016, 27 (2), pp.127 - 133. ⟨10.1089/hum.2015.141⟩
Journal articles hal-01407834v1

Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines

Thomas Démoulins , Panagiota Milona , Pavlos C. Englezou , Thomas Ebensen , Kai Schulze et al.
Nanomedicine: Nanotechnology, Biology and Medicine, 2016, 12 (3), pp.711 - 722. ⟨10.1016/j.nano.2015.11.001⟩
Journal articles hal-01406947v1

Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes

J. Barbeau , L. Lemiègre , A. Quelen , V. Malard , H. Gao et al.
Carbohydrate Research, 2016, 435, pp.142--148. ⟨10.1016/j.carres.2016.10.003⟩
Journal articles hal-01398046v1

Evidence for plasmid DNA exchange after polyplex mixing

L. Pigeon , C. Gonçalves , C. Pichon , P. Midoux
Soft Matter, 2016, 12 (33), pp.7012-7019. ⟨10.1039/c6sm00575f⟩
Journal articles hal-02069106v1

Engineered Nanoparticles Against MDR in Cancer: The State of the Art and its Prospective

Javed Ahmad , Sohail Akhter , Mohammad Ahmed Khan , Muhammad Wahajuddin , Nigel H. Greig et al.
Current Pharmaceutical Design, 2016, 22 (28), pp.4360-4373. ⟨10.2174/1381612822666160617112111⟩
Journal articles hal-02068807v1

Synthetic phospholipids and phospho-bola-amphiphiles for nucleic acid delivery

Mathieu Berchel , Olivier Lozach , Wilfried Berthe , Sylvie Hernot , Hélène Couthon et al.
Phosphorus, Sulfur, and Silicon and the Related Elements, 2016, 191 (11-12), pp.1485 - 1487. ⟨10.1080/10426507.2016.1212049⟩
Journal articles hal-01539538v1

Twelfth Annual Meeting of the French Society of Cell and Gene Therapy

Els Verhoeyen , Sophie Gomez , Anne Galy , Eduard Ayuso , Patrick Midoux et al.
Human Gene Therapy, 2016, 27 (7), pp.555-558. ⟨10.1089/hum.2016.29031.eve⟩
Journal articles hal-01469045v1

Gene delivery efficiency and intracellular trafficking of novel poly(allylamine) derivatives

Magdalena Wytrwal , Chloe Leduc , Michal Sarna , Cristine Goncalves , Mariusz Kepczynski et al.
International Journal of Pharmaceutics, 2015, 478 (1), pp.372-382. ⟨10.1016/j.ijpharm.2014.11.053⟩
Journal articles hal-01172009v1

Lipid-based mRNA vaccine delivery systems

Patrick Midoux , Chantal Pichon
Expert Review of Vaccines, 2015, 14 (2), pp.221-234. ⟨10.1586/14760584.2015.986104⟩
Journal articles hal-01171750v1
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Efficient gene delivery by sonoporation Is associated with microbubble entry into cells and the clathrin-dependent endocytosis pathway

Anthony Delalande , Chloe Leduc , Patrick Midoux , Michiel Postema , Chantal Pichon et al.
Ultrasound in Medicine & Biology, 2015, 41 (7), pp.1913-1926. ⟨10.1016/j.ultrasmedbio.2015.03.010⟩
Journal articles hal-03198520v1

Enhanced Achilles tendon healing by fibromodulin gene transfer

Anthony Delalande , Marie-Pierre Gosselin , Arnaud Suwalski , William Guilmain , Chloé Leduc et al.
Nanomedicine: Nanotechnology, Biology and Medicine, 2015, 11 (7), pp.1735 - 1744. ⟨10.1016/j.nano.2015.05.004⟩
Journal articles hal-01537597v1

Poly(2-methyl-2-oxazoline)-b-poly(tetrahydrofuran)-b-poly(2-methyl-2-oxazoline) Amphiphilic Triblock Copolymers: Synthesis, Physicochemical Characterizations, and Hydrosolubilizing Properties

Bazoly Rasolonjatovo , Jean-Pierre Gomez , William Même , Cristine Gonçalves , Cécile Huin et al.
Biomacromolecules, 2015, 16 (3), pp.748-756. ⟨10.1021/bm5016656⟩
Journal articles hal-01171865v1

Synthetic vectors for gene delivery: An overview of their evolution depending on routes of administration

Nawal Belmadi , Patrick Midoux , Pascal Loyer , Catherine Passirani , Chantal Pichon et al.
Biotechnology Journal, 2015, 10 (9), pp.1370-1389. ⟨10.1002/biot.201400841⟩
Journal articles hal-01162373v1

A robust transfection reagent for the transfection of CHO and HEK293 cells and production of recombinant proteins and lentiviral particles - PTG1

Cristine Gonçalves , Fabian Gross , Philippe Guégan , Hervé Cheradame , Patrick Midoux et al.
Biotechnology Journal, 2014, 9 (11), pp.1380-1388. ⟨10.1002/biot.201400324⟩
Journal articles hal-01179065v1

Lipopolyplexes comprising imidazole/imidazolium lipophosphoramidate, histidinylated polyethyleneimine and siRNA as efficient formulation for siRNA transfection

Cristine Gonçalves , Mathieu Berchel , Marie-Pierre Gosselin , Virginie Malard , Hervé Cheradame et al.
International Journal of Pharmaceutics, 2014, 460 (1-2), pp.264-272. ⟨10.1016/j.ijpharm.2013.11.005⟩
Journal articles hal-01179049v1

Improved gene transfer with histidine-​functionalized mesoporous silica nanoparticles

David Brevet , Ouahiba Hocine , Anthony Delalande , Laurence Raehm , Clarence Charnay et al.
International Journal of Pharmaceutics, 2014, pp.197-205. ⟨10.1016/j.ijpharm.2014.05.020⟩
Journal articles hal-01068026v1

Different affinity of nuclear factor-kappa B proteins to DNA modified by antitumor cisplatin and its clinically ineffective trans isomer

Jana Kasparkova , Thomas Thibault , Hana Kostrhunova , Jana Stepankova , Marie Vojtiskova et al.
FEBS Journal, 2014, 281 (5), pp.:1393-1408. ⟨10.1111/febs.12711⟩
Journal articles hal-01179156v1

Influence of pDNA availability on transfection efficiency of polyplexes in non-proliferative cells.

Benoit Maury , Cristine Gonçalves , Guillaume Tresset , Mehdi Zeghal , Hervé Cheradame et al.
Biomaterials, 2014, 35 (22), pp.5977-5985. ⟨10.1016/j.biomaterials.2014.04.007⟩
Journal articles hal-01179393v1

Improved nuclear delivery of antisense 2′-Ome RNA by conjugation with the histidine-rich peptide H5WYG

Ulysse Asseline , Cristine Gonçalves , Chantal Pichon , Patrick Midoux
The Journal of Gene Medicine, 2014, 16 (7-8), pp.157-165. ⟨10.1002/jgm.2773⟩
Journal articles hal-01175483v1

Editorial: Current status and prospects on nucleic acid transfer

Tristan Montier , Chantal Pichon , Marc Blondel , Patrick Midoux
Biotechnology Journal, 2014, 9 (11), pp.1363-1364. ⟨10.1002/biot.201300510⟩
Journal articles hal-02135170v1

NF-kB related transgene expression in mouse tibial cranial muscle after pDNA injection followed or not by electrotransfer.

S Mahindhoratep , H Ait Bouda , Nelly El Shafey , D Scherman , A Kichler et al.
BBA - Biochimica et Biophysica Acta, 2014, 1840 (11), pp.3257-3263
Journal articles hal-01179311v1

Poly- l -Lysine Compacts DNA, Kills Bacteria, and Improves Protease Inhibition in Cystic Fibrosis Sputum

Alice Dubois , Patrick Midoux , Delphine Gras , Mustapha Si-Tahar , Deborah Brea et al.
American Journal of Respiratory and Critical Care Medicine, 2013, 188 (6), pp.703-709. ⟨10.1164/rccm.201305-0912OC⟩
Journal articles hal-02070798v1

An E3-14.7K Peptide that Promotes Microtubules-Mediated Transport of Plasmid DNA Increases Polyplexes Transfection Efficiency.

Lucie Pigeon , Cristine Gonçalves , David Gosset , Chantal Pichon , Patrick Midoux et al.
Small, 2013, 9 (22), pp.3845-3851. ⟨10.1002/smll.201300217⟩
Journal articles hal-00840172v1

Trimethylarsonium-Based Cationic Phospholipids for Gene Delivery

Mathieu Berchel , Stéphanie Le Corre , Tony Le Gall , Hélène Couthon , Jean-Pierre Haelters et al.
Phosphorus, Sulfur, and Silicon and the Related Elements, 2013, 188 (1-3), pp.91-94. ⟨10.1080/10426507.2012.741161⟩
Journal articles hal-02070718v1
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Exogenous mRNA delivery and bioavailability in gene transfer mediated by piggyBac transposition

Solenne Bire , David Gosset , Gwenhael Jegot , Patrick Midoux , Chantal Pichon et al.
BMC Biotechnology, 2013, 13, pp.1-15. ⟨10.1186/1472-6750-13-75⟩
Journal articles hal-01129780v1

Interaction studies of muts and mutl with DNA containing the major cisplatin lesion and its mismatched counterpart under equilibrium and nonequilibrium conditions.

Yuliya Sedletska , Françoise Culard , Patrick Midoux , Jean-Marc Malinge
Biopolymers, 2013, 99 (9), pp.636-47. ⟨10.1002/bip.22232⟩
Journal articles hal-00874890v1
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Sonoporation: mechanistic insights and ongoing challenges for gene transfer

Anthony Delalande , Spiros Kotopoulis , Michiel Postema , Patrick Midoux , Chantal Pichon et al.
Gene, 2013, 525 (2), pp.191-199. ⟨10.1016/j.gene.2013.03.095⟩
Journal articles hal-03195625v1

Ability of plasmid DNA complexed with histidinylated lPEI and lPEI to cross in vitro lung and muscle vascular endothelial barriers

Jean-Pierre Gomez , Chantal Pichon , Patrick Midoux
Gene, 2013, 525 (2), pp.182-190. ⟨10.1016/j.gene.2013.03.055⟩
Journal articles hal-02070843v1

RILES, a novel method for temporal analysis of the in vivo regulation of miRNA expression.

Safia Ezzine , Georges Vassaux , Bruno Pitard , Benoit Barteau , Jean-Marc Malinge et al.
Nucleic Acids Research, 2013, epub ahead of print. ⟨10.1093/nar/gkt797⟩
Journal articles hal-00874881v1
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Gene transfer by histidylated lipopolyplexes: A dehydration method allowing preservation of their physicochemical parameters and transfection efficiency

Federico Perche , Olivier Lambert , Mathieu Berchel , Paul-Alain Jaffres , Chantal Pichon et al.
International Journal of Pharmaceutics, 2012, 423 (1), pp.144 - 150. ⟨10.1016/j.ijpharm.2011.04.009⟩
Journal articles hal-02995807v1

Ultrasound and microbubble-assisted gene delivery: recent advances and ongoing challenges.

Anthony Delalande , Michiel Postema , Nathalie Mignet , Patrick Midoux , Chantal Pichon et al.
Ther Deliv, 2012, 3 (10), pp.1199-1215
Journal articles hal-00817350v1

Lipophosphonate/lipophosphoramidates: a family of synthetic vectors efficient for gene delivery.

Mathieu Berchel , Tony Le Gall , Hélène Couthon , Jean-Pierre Haelters , Tristan Montier et al.
Biochimie, 2012, 94 (1), pp.33-41. ⟨10.1016/j.biochi.2011.07.026⟩
Journal articles hal-00721772v1

Gene transfer by chemical vectors, and endocytosis routes of polyplexes, lipoplexes and lipopolyplexes in a myoblast cell line.

Ludivine Billiet , Jean-Pierre Gomez , Mathieu Berchel , Paul-Alain Jaffres , Tony Le Gall et al.
Biomaterials, 2012, 33 (10), pp.2980-2990. ⟨10.1016/j.biomaterials.2011.12.027⟩
Journal articles hal-00721795v1
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Ultrasound and microbubble-assisted gene delivery: recent advances and ongoing challenges

Anthony Delalande , Michiel Postema , Nathalie Mignet , Patrick Midoux , Chantal Pichon et al.
Therapeutic Delivery, 2012, 3 (10), pp.1199-1215. ⟨10.4155/TDE.12.100⟩
Journal articles hal-03193228v1

Supramolecular assemblies of histidinylated α-cyclodextrin in the presence of DNA scaffold during CDplexes formation.

Véronique Bennevault-Celton , Allan Urbach , Olivier Martin , Chantal Pichon , Philippe Guégan et al.
Bioconjugate Chemistry, 2011, 22 (12), pp.2404-14. ⟨10.1021/bc200167p⟩
Journal articles hal-00720527v1

New Lipo-Phosphoramidates for Gene Delivery

Paul-Alain Jaffres , Aurore Fraix , Christophe Lorilleux , Mathieu Berchel , Hélène Couthon et al.
Phosphorus, Sulfur, and Silicon and the Related Elements, 2011, 186 (4), pp.918-920. ⟨10.1080/10426507.2010.522639⟩
Journal articles hal-00614938v1

Modular Construction of Fluorescent Lipophosphoramidates by Click Chemistry

Mathieu Berchel , Jean-Piere Haelters , Hélène Couthon , Laure Burel-Deschamps , Patrick Midoux et al.
European Journal of Organic Chemistry, 2011, 31, pp.6294-6303. ⟨10.1002/ejoc.201100900⟩
Journal articles hal-00720537v1

Selective gene delivery in dendritic cells with mannosylated and histidylated lipopolyplexes.

Federico Perche , David Gosset , Mathieu Mével , Marie-Laure Miramon , Jean-Jacques Yaouanc et al.
Journal of Drug Targeting, 2011, 19 (5), pp.315-25. ⟨10.3109/1061186X.2010.504262⟩
Journal articles hal-00753554v1
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Ultrasound and microbubble-assisted gene delivery in Achilles tendons: long lasting gene expression and restoration of fibromodulin KO phenotype

Anthony Delalande , Ayache Bouakaz , Gilles Renault , Flore Tabareau , Spiros Kotopoulis et al.
Journal of Controlled Release, 2011, 156 (2), pp.223-230. ⟨10.1016/j.jconrel.2011.08.020⟩
Journal articles hal-03195121v1

Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer.

Emilie Bertrand , Cristine Gonçalves , Ludivine Billiet , Jean Pierre Gomez , Chantal Pichon et al.
Chemical Communications, 2011, 47 (46), pp.12547-12549. ⟨10.1039/c1cc15716g⟩
Journal articles hal-00720539v1

Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA.

Federico Perche , Thierry Benvegnu , Mathieu Berchel , Loic Lebegue , Chantal Pichon et al.
Nanomedicine: Nanotechnology, Biology and Medicine, 2011, 7 (4), pp.445-53. ⟨10.1016/j.nano.2010.12.010⟩
Journal articles hal-00754373v1

Transient transmembrane release of green fluorescent proteins with sonoporation

K. Kaddur , L. Lebegue , F. Tranquart , P. Midoux , C. Pichon et al.
IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 2010, 57 (7), pp.1558-1567. ⟨10.1109/TUFFC.2010.1586⟩
Journal articles hal-00529340v1

Chemical vectors for gene delivery: uptake and intracellular trafficking

Chantal Pichon , Ludivine Billiet , Patrick Midoux
Current Opinion in Biotechnology, 2010, 21 (5), pp.640-645. ⟨10.1016/j.copbio.2010.07.003⟩
Journal articles hal-00602488v1

Uptake of Functionalized Mesoporous Silica Nanoparticles by Human Cancer Cells

Matthieu Fisichella , Hinda Dabboue , Sanjib Bhattacharyya , Gerald Lelong , Marie-Louise Saboungi et al.
Journal of Nanoscience and Nanotechnology, 2010, 10 (4), pp.314-2324. ⟨10.1166/jnn.2010.1917⟩
Journal articles hal-00529333v1

Ultrasound-assisted microbubbles gene transfer in tendons for gene therapy

Anthony Delalande , Michel-Francis Bureau , Patrick Midoux , Ayache Bouakaz , Chantal Pichon et al.
Ultrasonics Sonochemistry, 2010, 50 (2), pp.269-272. ⟨10.1016/j.ultras.2009.09.035⟩
Journal articles hal-00529321v1
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Accelerated Achilles tendon healing by PDGF gene delivery with mesoporous silica nanoparticles

Arnaud Suwalski , Hinda Dabboue , Anthony Delalande , Sabine F. Bensamoun , Francis Canon et al.
Biomaterials, 2010, 31 (19), pp.5237-5245. ⟨10.1016/j.biomaterials.2010.02.077⟩
Journal articles hal-00529475v1

Histidine-rich peptide: evidence for a single zinc-binding site on H5WYG peptide that promotes membrane fusion at neutral pH

Corinne Bure , Régine Maget , Agnès F. Delmas , Chantal Pichon , Patrick Midoux et al.
Journal of Mass Spectrometry, 2009, 44 (1), pp.81-89. ⟨10.1002/jms.1473⟩
Journal articles hal-00521834v1

An optimized extended DNA kappa B site that enhances plasmid DNA nuclear import and gene expression

Cristine Gonçalves , Maryvonne Ardourel , Martine Decoville , Gilles Breuzard , Patrick Midoux et al.
The Journal of Gene Medicine, 2009, 11 (5), pp.401-411. ⟨10.1002/jgm.1312⟩
Journal articles hal-00522437v1

Involvement of histidines 11, 15 and 19 in the binding of zinc to the fusogenic H5WYG peptide

Corinne Bure , Chantal Pichon , Patrick Midoux
Journal of Mass Spectrometry, 2009, 44 (8), pp.1163-1170. ⟨10.1002/jms.1591⟩
Journal articles hal-00521851v1
Image document

Comparative gene transfer between cationic and thiourea lipoplexes

Marie Breton , Jeanne Leblond , Johanne Seguin , Patrick Midoux , Daniel Scherman et al.
The Journal of Gene Medicine, 2009, 12 (1), pp.45-54. ⟨10.1002/jgm.1417⟩
Journal articles hal-02512540v1

Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers

Patrick Midoux , Chantal Pichon , Jean-Jacques Yaouanc , Paul-Alain Jaffres
British Journal of Pharmacology, 2009, 157 (2), pp.166-178. ⟨10.1111/j.1476-5381.2009.00288.x⟩
Journal articles hal-00525108v1

Novel neutral imidazole-lipophosphoramides for transfection assays

M. Mevel , C. Neveu , Cristine Goncalves , J.-J. Yaouanc , Chantal Pichon et al.
Chemical Communications, 2008, 27, pp.3124-3126. ⟨10.1039/b805226c⟩
Journal articles hal-00518192v1

Polymer-Based Gene Delivery: A Current Review on the Uptake and Intracellular Trafficking of Polyplexes

Patrick Midoux , Gilles Breuzard , Jean-Pierre Gomez , Chantal Pichon
Current Gene Therapy, 2008, 8 (5), pp.335-352
Journal articles hal-00518197v1

Glycofection: The Ubiquitous Roles of Sugar Bound on Glycoplexes

Valerie Boutin , Alain Legrand , Roger Mayer , Maurice Nachtigal , Michel Monsigny et al.
Drug Delivery, 2008, 6 (1), pp.45-50. ⟨10.1080/107175499267156⟩
Journal articles hal-02138035v1

Synthesis and transfection activity of new cationic phosphoramidate lipids: High efficiency of an imidazolium derivative

M. Mevel , Gilles Breuzard , J.-J. Yaouanc , J.-C. Clement , P. Lehn et al.
ChemBioChem, 2008, 9 (9), pp.1462-1471. ⟨10.1002/cbic.200700727⟩
Journal articles hal-00518184v1

Nuclear delivery of NFkappaB-assisted DNA/polymer complexes: plasmid DNA quantitation by confocal laser scanning microscopy and evidence of nuclear polyplexes by FRET imaging.

Gilles Breuzard , Magdalena Tertil , Cristine Gonçalves , Hervé Cheradame , Philippe Géguan et al.
Nucleic Acids Research, 2008, 36 (12), pp.e71. ⟨10.1093/nar/gkn287⟩
Journal articles hal-00408004v1

Recent advances in gene delivery with ultrasound and microbubbles

Chantal Pichon , Kadija Kaddur , Patrick Midoux , François Tranquart , Ayache Bouakaz et al.
Journal of Experimental Nanoscience, 2008, 3 (1), pp.17-40. ⟨10.1080/17458080801993422⟩
Journal articles hal-00518203v1
Image document

Cationic Lipids Based on Phosphonate and Phosphoramidate Chemistry: Synthesis and Application to Gene Therapy

Mathieu Mével , Jean-Jacques Yaouanc , Pascal Laurent , Claude Clément , Dominique Cartier et al.
Phosphorus, Sulfur, and Silicon and the Related Elements, 2008, 183 (2-3), pp.460-468. ⟨10.1080/10426500701761300⟩
Journal articles hal-01580434v1

Extraction of green fluorescent proteins with sonoporation

Kadija Kaddur , Anthony Delalande , François Tranquart , Patrick Midoux , Chantal Pichon et al.
Journal of the Acoustical Society of America, 2008, 123 (5), pp.3218-3218. ⟨10.1121/1.2933412⟩
Journal articles hal-02128161v1

Intracellular trafficking and nuclear import of polyplexes by FRET coupled with cellular imaging

Gilles Breuzard , M. Tertil , Chantal Pichon , Patrick Midoux
Human Gene Therapy, 2007, 18, pp.1048
Journal articles hal-00275215v1

mRNA-based cancer vaccine: prevention of B16 melanoma progression and metastasis by systemic injection of MART1 mRNA histidylated lipopolyplexes.

M. Mockey , E. Bourseau , V. Chandrashekhar , A. Chaudhuri , S. Lafosse et al.
Cancer Gene Therapy, 2007, 14 (9), pp.802-14. ⟨10.1038/sj.cgt.7701072⟩
Journal articles hal-00318514v1

mRNA-based cancer vaccine: prevention of B16 melanoma progression and metastasis by systemic injection of MART1 mRNA histidylated lipopolyplexes

M. Mockey , E Bourseau , V Chandrashekhar , A. Chaudhuri , S. Lafosse et al.
Cancer Gene Therapy, 2007, 14 (9), pp.802-814. ⟨10.1038/sj.cgt.7701072⟩
Journal articles hal-03065277v1

DNA/cationic polymer complex attachment on a human vascular endothelial cell monolayer exposed to a steady laminar flow

Eric Mennesson , Patrick Erbacher , Mateusz Kuzak , Claudine Kieda , Patrick Midoux et al.
Journal of Controlled Release, 2006, 114 (3), pp.389-397. ⟨10.1016/j.jconrel.2006.06.006⟩
Journal articles hal-00112894v1

mRNA transfection of dendritic cells: synergistic effect of ARCA mRNA capping with Poly(A) chains in cis and in trans for a high protein expression level

M. Mockey , C. Goncalves , F.P. Dupuy , F.M. Lemoine , C. Pichon et al.
Biochemical and Biophysical Research Communications, 2006, 340, pp.1062-1068. ⟨10.1016/j.bbrc.2005.12.105⟩
Journal articles hal-00088921v1

Transfection efficiency and uptake process of polyplexes in human lung endothetial cells: a comparative study in non-polarized and polarized cells

E. Mennesson , P. Erbacher , V. Piller , C. Kieda , P. Midoux et al.
The Journal of Gene Medicine, 2005, 7, pp.729-738
Journal articles hal-00088642v1

Macropinocytosis of polyplexes and recycling of plasmid via the clathrin-dependant pathway impair the transfection efficiency into human hepatocarcinoma cells

C. Goncalves , E. Mennesson , R. Fuchs , Gorvel J.P. , Patrick Midoux et al.
Molecular Therapy, 2004, 10, pp.373-385
Journal articles hal-00113047v1

Optimization of in vitro vascular cell transfection with non-viral vectors for in vivo applications

Ibrahim Elmadbouh , Patrick Rossignol , Olivier Meilhac , Roger Vranckx , Chantal Pichon et al.
The Journal of Gene Medicine, 2004, 6 (10), pp.1112-1124
Journal articles hal-00014241v1

Non-viral vectors in cystic fibrosis gene therapy: progress and challenges

T. Montier , P. Delépine , C. Pichon , C. Férec , D.J. Porteous et al.
Trends in biotechnology., 2004, 22, pp.586-592
Journal articles hal-00088424v1

On the gene delivery efficacies of pH-sensitive cationic lipids via endosomal protonation: a chemical biology investigation

R.S. Singh , C. Gonçalves , P. Sandrin , C. Pichon , P. Midoux et al.
Chemistry & biology, 2004, 11, pp.713-723
Journal articles hal-00088426v1

An efficient and facile nitration of phenols with nitric acid/zinc chloride under ultrasonic conditions

A. Kamal , B.A. Kumar , M. Arifuddin , P. Midoux
Ultrasonics Sonochemistry, 2004, 11, pp.455-457
Journal articles hal-00088378v1

Poly[Lys-(AEDTP)]: A Cationic Polymer That Allows Dissociation of pDNA/Cationic Polymer Complexes in a Reductive Medium and Enhances Polyfection

Chantal Pichon , Eric Le Cam , Brigitte Guérin , Dominique Coulaud , Etienne Delain et al.
Bioconjugate Chemistry, 2002, 13 (1), pp.76-82. ⟨10.1021/bc015503o⟩
Journal articles hal-03065338v1

Single histidine residue in head-group region is sufficient to impart remarkable gene transfection properties to cationic lipids: evidence for histidine-mediated membrane fusion at acidic pH

V Kumar , Chantal Pichon , M. Refregiers , B Guerin , P. Midoux et al.
Gene Therapy, 2002, 10 (15), pp.1206 - 1215. ⟨10.1038/sj.gt.3301979⟩
Journal articles hal-01596052v1

Zinc improves gene transfer mediated by DNA/cationic polymer complexes

Chantal Pichon , Brigitte Guérin , Matthieu M. Refregiers , Christine Gonçalves , Paul Vigny et al.
The Journal of Gene Medicine, 2002, 4 (5), pp.548 - 559. ⟨10.1002/jgm.303⟩
Journal articles hal-01596013v1

Intracellular processing and stability of DNA complexed with histidylated polylysine conjugates

Christine Gonçalves , Chantal Pichon , Brigitte Guérin , Patrick Midoux
The Journal of Gene Medicine, 2002, 4 (3), pp.271-281. ⟨10.1002/jgm.277⟩
Journal articles hal-02135970v1

Histidine containing peptides and polypeptides as nucleic acid vectors.

Patrick Midoux , Eric Le Cam , Dominique Coulaud , Etienne Delain , Chantal Pichon et al.
Somatic Cell and Molecular Genetics, 2002, 27 (1-6), pp.27-47. ⟨10.1023/a:1022931923153⟩
Journal articles hal-03065331v1

Nonviral gene transfer into primary cultures of human and porcine mesothelial cells.

J Ohan , M.A Gilbert , G Leseche , Y Panis , P. Midoux et al.
In Vitro Cellular & Developmental Biology - Animal, 2001, 37 (7), pp.402-7
Journal articles hal-02161118v1

Histidylated polylysine as DNA vector: elevation of the imidazole protonation and reduced cellular uptake without change in the polyfection efficiency of serum stabilized negative polyplexes.

M Bello Roufaï , P. Midoux
Bioconjugate Chemistry, 2001, 12 (1), pp.92-9. ⟨10.1021/bc0000738⟩
Journal articles hal-02161122v1

Histidine-rich peptides and polymers for nucleic acids delivery.

Chantal Pichon , C Gonçalves , P. Midoux
Advanced Drug Delivery Reviews, 2001, 53 (1), pp.75-94
Journal articles hal-02135973v1

Efficient Gene Transfer into Human Normal and Cystic Fibrosis Tracheal Gland Serous Cells with Synthetic Vectors

J.C Allo , Patrick Midoux , Marc Merten , Evelyne Souil , Joanna Lipecka et al.
American Journal of Respiratory Cell and Molecular Biology, 2000, 22 (2), pp.166-175. ⟨10.1165/ajrcmb.22.2.3722⟩
Journal articles hal-02161132v1

Histidylated oligolysines increase the transmembrane passage and the biological activity of antisense oligonucleotides

Chantal Pichon , Mahajoub Bello Roufaï , Michel Monsigny , Patrick Midoux
Nucleic Acids Research, 2000, 28 (2), pp.504-512. ⟨10.1093/nar/28.2.504⟩
Journal articles hal-02135979v1

Histidylated polylysine as a synthetic vector for gene transfer into immortalized cystic fibrosis airway surface and airway gland serous cells

Isabelle Fajac , J.C Allo , Evelyne Souil , Marc Merten , Chantal Pichon et al.
The Journal of Gene Medicine, 2000, 2 (5), pp.368-378. ⟨10.1002/1521-2254(200009/10)2:5<368::AID-JGM118>3.0.CO;2-F⟩
Journal articles hal-02135988v1

Spacer length dependence on the efficiency of dimeric anionic peptides in gene transfer by glycosylated polylysine/plasmid complexes.

I. Freulon , M. Monsigny , P. Midoux , R. Mayer
Bioscience Reports, 2000, 20 (5), pp.383-398. ⟨10.1023/a:1010382001654⟩
Journal articles hal-02161127v1

Efficient Gene Transfer by Histidylated Polylysine/pDNA Complexes

Patrick Midoux , Michel Monsigny
Bioconjugate Chemistry, 1999, 10 (3), pp.406-411. ⟨10.1021/bc9801070⟩
Journal articles hal-02161145v1

GlycofectionTM in the presence of anionic fusogenic peptides: a study of the parameters affecting the peptide-mediated enhancement of the transfection efficiency

Antoine Kichler , Isabelle Freulon , Valerie Boutin , Roger Mayer , Michel Monsigny et al.
The Journal of Gene Medicine, 1999, 1 (2), pp.134-143. ⟨10.1002/(SICI)1521-2254(199903/04)1:2<134::AID-JGM17>3.0.CO;2-B⟩
Journal articles hal-02161144v1

Sugar-Mediated Uptake of Glycosylated Polylysines and Gene Transfer into Normal and Cystic Fibrosis Airway Epithelial Cells

Isabelle Fajac , Pascale Briand , Michel Monsigny , Patrick Midoux
Human Gene Therapy, 1999, 10 (3), pp.395-406. ⟨10.1089/10430349950018841⟩
Journal articles hal-02161152v1

Membrane Permeabilization and Efficient Gene Transfer by a Peptide Containing Several Histidines

Patrick Midoux , Antoine Kichler , Valerie Boutin , Jean-Claude Maurizot , Michel Monsigny et al.
Bioconjugate Chemistry, 1998, 9 (2), pp.260-267. ⟨10.1021/bc9701611⟩
Journal articles hal-02161162v1

Novel Glycosynthons for Glycoconjugate Preparation: Oligosaccharylpyroglutamylanilide Derivatives

Christophe Quétard , Sylvain Bourgerie , Nadia Normand-Sdiqui , Roger Mayer , Gérard Strecker et al.
Bioconjugate Chemistry, 1998, 9 (2), pp.268-276. ⟨10.1021/bc970122p⟩
Journal articles hal-02161157v1

Glycotargeting: the preparation of glyco-amino acids and derivatives from unprotected reducing sugars.

M Monsigny , C. Quétard , S. Bourgerie , D. Delay , Chantal Pichon et al.
Biochimie, 1998, 80 (2), pp.99-108
Journal articles hal-02136005v1

Specific Gene Transfer Based on Biotinylated and Gluconoylated Polylysine/Plasmid Complexes

Patrick Erbacher , Annie Claude Roche , Michel Monsigny , Patrick Midoux
Drug Delivery, 1997, 4 (3), pp.173-179. ⟨10.3109/10717549709051889⟩
Journal articles hal-02161332v1

Glycosylated Polylysines. Nonviral vectors for gene transfer into cystic fibrosis airway epithelial cells.

Wouter Kollen , Patrick Erbacher , Patrick Midoux , Annie-Claude Roche , Michel Monsigny et al.
Chest, 1997, 111 (6), pp.95S-96S. ⟨10.1378/chest.111.6_supplement.95s⟩
Journal articles hal-02161319v1

Fluorescent labelling of unmodified phosphorothioate oligodeoxynucleotides: Synthesis and characterization

A.J. Stewart , Chantal Pichon , Patrick Midoux , R. Mayer , Michel Monsigny et al.
New Journal of Chemistry, 1997, 21 (1), pp.87-98
Journal articles hal-02161369v1

Cytosolic and Nuclear Delivery of Oligonucleotides Mediated by an Amphiphilic Anionic Peptide

Chantal Pichon , Isabelle Freulon , Patrick Midoux , Roger Mayer , Michel Monsigny et al.
Antisense and Nucleic Acid Drug Development, 1997, 7 (4), pp.335-343. ⟨10.1089/oli.1.1997.7.335⟩
Journal articles hal-02136009v1

The reduction of the positive charges of polylysine by partial gluconoylation increases the transfection efficiency of polylysine/DNA complexes

Patrick Erbacher , Annie Claude Roche , Michel Monsigny , Patrick Midoux
Biochimica et Biophysica Acta:Biomembranes, 1997, 1324 (1), pp.27-36. ⟨10.1016/s0005-2736(96)00204-0⟩
Journal articles hal-02161372v1

Gluconoylated and Glycosylated Polylysines As Vectors for Gene Transfer into Cystic Fibrosis Airway Epithelial Cells

Wouter Kollen , Patrick Midoux , Patrick Erbacher , Alex Yip , Annie Claude Roche et al.
Human Gene Therapy, 1996, 7 (13), pp.1577-1586. ⟨10.1089/hum.1996.7.13-1577⟩
Journal articles hal-02161378v1

Gene Transfer by DNA/Glycosylated Polylysine Complexes into Human Blood Monocyte-Derived Macrophages

Patrick Erbacher , Marie-Thérèse Bousser , Jacques Raimond , Michel Monsigny , Patrick Midoux et al.
Human Gene Therapy, 1996, 7 (6), pp.721-729. ⟨10.1089/hum.1996.7.6-721⟩
Journal articles hal-02161390v1

Expression of a mannose/fucose membrane lectin on human dendritic cells

Alexandre Avraméas , Dorian Mcilroy , Anne Hosmalin , Brigitte Autran , Patrice Debré et al.
European Journal of Immunology, 1996, 26 (2), pp.394-400. ⟨10.1002/eji.1830260219⟩
Journal articles hal-02161396v1

Enhanced biological activity of antisense oligonucleotides complexed with glycosylated poly-L-lysine.

A. Stewart , Chantal Pichon , L Meunier , P Midoux , M. Monsigny et al.
Molecular Pharmacology, 1996, 50 (6), pp.1487-94
Journal articles hal-02136015v1

Putative Role of Chloroquine in Gene Transfer into a Human Hepatoma Cell Line by DNA/Lactosylated Polylysine Complexes

Patrick Erbacher , Annie Claude Roche , Michel Monsigny , Patrick Midoux
Experimental Cell Research, 1996, 225 (1), pp.186-194. ⟨10.1006/excr.1996.0169⟩
Journal articles hal-02161382v1

Glycosylated polylysine/DNA complexes: gene transfer efficiency in relation with the size and the sugar substitution level of glycosylated polylysines and with the plasmid size.

P Erbacher , A.C. Roche , M. Monsigny , P. Midoux
Bioconjugate Chemistry, 1995, 6 (4), pp.401-10. ⟨10.1021/bc00034a010⟩
Journal articles hal-02161414v1

Membrane permeabilization by α-helical peptides: a flow cytometry study

Patrick Midoux , Roger Mayer , Michel Monsigny
Biochimica et Biophysica Acta:Biomembranes, 1995, 1239 (2), pp.249-256. ⟨10.1016/0005-2736(95)00163-w⟩
Journal articles hal-02161407v1

Inhibition of Human Mammary Cell Line Proliferation by Membrane Lectin-Mediated Uptake of Ha- ras Antisense Oligodeoxynucleotide

Nadia Sdiqui , Khalil Arar , Patrick Midoux , Roger Mayer , Michel Monsigny et al.
Drug Delivery, 1994, 2 (1), pp.63-72. ⟨10.3109/10717549509031353⟩
Journal articles hal-02161404v1

Glycoconjugates as carriers for specific delivery of therapeutic drugs and genes

Michel Monsigny , Annie-Claude Roche , Patrick Midoux , Roger Mayer
Advanced Drug Delivery Reviews, 1994, 14 (1), pp.1-24. ⟨10.1016/0169-409X(94)90003-5⟩
Journal articles hal-02163748v1

Endocytosis of alpha 1-acid glycoprotein variants by human monocytic lineage cells.

V. Carpentier , Patrick Midoux , M. Monsigny , A.C. Roche
Biology of the Cell, 1993, 77 (2), pp.187-93. ⟨10.1016/S0248-4900(05)80187-X⟩
Journal articles hal-02161453v1

Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells

Patrick Midoux , Christina Mendes , Alain Legrand , Jacques Raimond , Roger Mayer et al.
Nucleic Acids Research, 1993, 21 (4), pp.871-878. ⟨10.1093/nar/21.4.871⟩
Journal articles hal-02138456v1

Perspectives ex vivo et in vivo pour la thérapie génique, de la transfection sélective à l'aide de complexes plasmide-polylysine ciblés

M. Monsigny , P. Midoux , A.C. Roche
médecine/sciences, 1993, 9 (4), pp.441. ⟨10.4267/10608/2938⟩
Journal articles hal-02163755v1

Drug targeting: synthesis and endocytosis of oligonucleotide-neoglycoprotein conjugates

N Bonfils , C. Depierreux , P. Midoux , N.T. Thuong , M. Monsigny et al.
Nucleic Acids Research, 1992, 20 (17), pp.4621-4629. ⟨10.1093/nar/20.17.4621⟩
Journal articles hal-02161479v1

Uptake by macrophages of a biotinylated oligo-alpha-deoxythymidylate by using mannosylated streptavidin.

E Bonfils , C. Mendes , A.C. Roche , M. Monsigny , P. Midoux et al.
Bioconjugate Chemistry, 1992, 3 (4), pp.277-284. ⟨10.1021/bc00016a004⟩
Journal articles hal-02161474v1

Activation of mouse macrophages by muramyl dipeptide coupled with an anti-macrophage monoclonal antibody.

Patrick Midoux , A. Martin , B Collet , M. Monsigny , A.C. Roche et al.
Bioconjugate Chemistry, 1992, 3 (2), pp.194-9. ⟨10.1021/bc00014a016⟩
Journal articles hal-02161456v1

Characterization and isolation of an intracellular D-mannose-specific receptor from human promyelocytic HL60 cells.

V Pimpaneau , Patrick Midoux , M. Monsigny , A.C. Roche
Carbohydrate Research, 1991, 213, pp.95-108. ⟨10.1016/S0008-6215(00)90601-3⟩
Journal articles hal-02162388v1

Production of macrophage-derived cytotoxic factor by N-[3-[(carbamoylmethyl)thio]propionylated] neoglycoproteins.

P Breton , Patrick Midoux , Christian Petit , M Bousser , A.C Roche et al.
Bioconjugate Chemistry, 1991, 2 (1), pp.16-8
Journal articles hal-02162393v1

Benzoxazinone kanamycin A conjugate. A new fluorescent probe suitable to detect mycoplasmas in cell culture.

M Monsigny , Patrick Midoux , C. Depierreux , C Bebear , M.T Le Bris et al.
Biology of the Cell, 1990, 70 (3), pp.101-105. ⟨10.1016/0248-4900(90)90365-A⟩
Journal articles hal-02163189v1

Drug targeting: Anti-HSV-1 activity of mannosylated polymer-bound 9-(2-phosphonylmethoxyethyl)adenine

Patrick Midoux , Eric Negre , Annie-Claude Roche , Roger Mayer , Michel Monsigny et al.
Biochemical and Biophysical Research Communications, 1990, 167 (3), pp.1044-1049. ⟨10.1016/0006-291x(90)90628-z⟩
Journal articles hal-02163192v1

Macrophage antigens associated with adhesion: identification by a monoclonal antibody specific for Lewis lung carcinoma cells.

Patrick Midoux , Christian Petit , P Pellen , L Toujas , M. Monsigny et al.
Experimental Cell Research, 1989, 183 (1), pp.168-178. ⟨10.1016/0014-4827(89)90427-8⟩
Journal articles hal-02163384v1

Benzoxazinone derivatives: new fluorescent probes for two-color flow cytometry analysis using one excitation wavelength.

M Monsigny , Patrick Midoux , M.T Le Bris , A.C Roche , B Valeur et al.
Biology of the Cell, 1989, 67 (2), pp.193-200. ⟨10.1111/j.1768-322X.1989.tb00862.x⟩
Journal articles hal-02163198v1

Muramyl dipeptide bound to poly-L-lysine substituted with mannose and gluconoyl residues as macrophage activators.

D Derrien , Patrick Midoux , Christian Petit , E. Negre , R. Mayer et al.
Glycoconjugate Journal, 1989, 6 (2), pp.241-255. ⟨10.1007/BF01050652⟩
Journal articles hal-02163397v1

Endocytosis of alpha 1-acid glycoprotein variants and of neoglycoproteins containing mannose derivatives by a mouse hybridoma cell line (2C11-12). Comparison with mouse peritoneal macrophages.

V Pimpaneau , Patrick Midoux , Geoffroy Durand , P de Baetselier , M. Monsigny et al.
Glycoconjugate Journal, 1989, 6 (4), pp.561-574. ⟨10.1007/BF01053778⟩
Journal articles hal-02163197v1

Endogenous Lectins and Drug Targeting

M. Monsigny , A.C Roche , P. Midoux
Annals of the New York Academy of Sciences, 1988, 551, pp.399-414. ⟨10.1111/j.1749-6632.1988.tb22373.x⟩
Journal articles hal-02163799v1

Characterization and biological implications of membrane lectins in tumor, lymphoid and myeloid cells.

M Monsigny , Annie Claude Roche , C. Kieda , P. Midoux , A Obrénovitch et al.
Biochimie, 1988, 70 (11), pp.1633-49. ⟨10.1016/0300-9084(88)90299-4⟩
Journal articles hal-02163758v1

Quantitation of the binding, uptake, and degradation of fluoresceinylated neoglycoproteins by flow cytometry

Patrick Midoux , Annie-Claude Roche , Michel Monsigny
Cytometry, 1987, 8 (3), pp.327-334. ⟨10.1002/cyto.990080314⟩
Journal articles hal-02163401v1

Characterization of membrane lectins in human colon carcinoma cells by flow cytofluorometry, drug targeting and affinity chromatography.

Hj Gabius , R Engelhardt , T Hellmann , Patrick Midoux , M. Monsigny et al.
Anticancer Research, 1987, 7 (1), pp.109-112
Journal articles hal-02163405v1

Estimation of the degradation of endocytosed material by flow cytofluorometry using two neoglycoproteins containing different numbers of fluorescein molecules.

Patrick Midoux , A.C Roche , M. Monsigny
Biology of the Cell, 1986, 58 (3), pp.221-225
Journal articles hal-02163590v1

Analysis of sugar-binding sites in mammalian cell nuclei by quantitative flow microfluorometry.

A Sève , J. Hubert , D. Bouvier , C. Bourgeois , P. Midoux et al.
Proceedings of the National Academy of Sciences of the United States of America, 1986, 83 (16), pp.5997-6001. ⟨10.1073/pnas.83.16.5997⟩
Journal articles hal-02163583v1

Membrane lectins on human monocytes. Maturation-dependent modulation of 6-phosphomannose and mannose receptors.

Annie-Claude Roche , Patrick Midoux , Philippe Bouchard , Michel Monsigny
FEBS Letters, 1985, 193 (1), pp.63-68. ⟨10.1016/0014-5793(85)80080-6⟩
Journal articles hal-02163594v1

Selective macrophage activation by muramyldipeptide bound to monoclonal antibodies specific for mouse tumor cells.

Annie Claude Roche , P Bailly , Patrick Midoux , M. Monsigny
Cancer Immunology, Immunotherapy, 1984, 18 (3), pp.155-159
Journal articles hal-02163604v1

Monoclonal antibodies (IgM) against a murine carcinoma, Lewis lung carcinoma (3LL): production, purification and in vitro selectivity.

Patrick Midoux , Annie-Claude Roche , M. Monsigny
Immunology Letters, 1984, 8 (3), pp.131-136. ⟨10.1016/0165-2478(84)90065-8⟩
Journal articles hal-02163712v1

The binding of monosaccharides to wheat germ agglutinin: Fluorescence and NMR investigations

P. Midoux , J.P Grivet , F. Delmotte , M. Monsigny
Biochemical and Biophysical Research Communications, 1984, 119 (2), pp.603-611. ⟨10.1016/s0006-291x(84)80292-2⟩
Journal articles hal-02163716v1

Uptake of neoglycoproteins via membrane lectin(s) of L1210 cells evidenced by quantitative flow cytofluorometry and drug targeting.

M. Monsigny , Annie-Claude Roche , P. Midoux
Biology of the Cell, 1984, 51 (2), pp.187-196. ⟨10.1111/j.1768-322X.1984.tb00298.x⟩
Journal articles hal-02163609v1

Tumor localization of Lewis lung carcinoma with radiolabeled monoclonal antibodies

Patrick Midoux , Thierry Maillet , Fabienne Therain , Michel Monsigny , Annie-Claude Roche et al.
Cancer Immunology, Immunotherapy, 1984, 18 (1), pp.19-23. ⟨10.1007/BF00205394⟩
Journal articles hal-02163698v1

Fluorescence quenching of tryptophan by trifluoroacetamide

Patrick Midoux , Philippe Wahl , Jean-Claude Auchet , Michel Monsigny
Biochimica et Biophysica Acta (BBA) - General Subjects, 1984, 801 (1), pp.16-25. ⟨10.1016/0304-4165(84)90207-1⟩
Journal articles hal-02163704v1

Protein-sugar interactions: Environmental effect on the fluorescence of O-(4-methylumbelliferyl)-glycosides

P. Midoux , F. Delmotte , J.Ph Grivet , M. Monsigny
Biochemical and Biophysical Research Communications, 1983, 110 (3), pp.926-933. ⟨10.1016/0006-291X(83)91051-3⟩
Journal articles hal-02163727v1

Sugar-specific endocytosis of glycoproteins by Lewis lung carcinoma cells

A.C Roche , M. Barzilay , P. Midoux , S. Junqua , N. Sharon et al.
Journal of Cellular Biochemistry, 1983, 22 (3), pp.131-140. ⟨10.1002/jcb.240220302⟩
Journal articles hal-02163725v1

Lectin-sugar interactions: the binding of 1- O -methyl-di- N -trifluoroacetyl-β-chitobioside to wheat germ agglutinin

M Midoux , J.-Ph. Grivet , M. Monsigny , P. Midoux
FEBS Letters, 1980, 120 (1), pp.29-32. ⟨10.1016/0014-5793(80)81038-6⟩
Journal articles hal-02163732v1

Influence of the charge of mRNA mannosylated lipopolyplexes on the binding and uptake by dendritic cells

C Delehedde , G Haifei , C Gonçalves , Virginie Malard , N Rameix et al.
33e colloque Biotechnocentre, Oct 2021, Seillac, France
Conference papers hal-03668427v1

High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells

N Laroui , C Delehedde , C Goncalves , F Godin , Federico Perche et al.
SFNano 2021, Dec 2021, Angers, France
Conference papers hal-03668422v1
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Positively charged microbubbles to target nucleic acid delivery with ultrasound

Simona Manta , Anthony Delalande , Gilles Renault , Michel Francis Bureau , Matthias Lebertre et al.
Journées RITS 2015, Mar 2015, Dourdan, France
Conference papers inserm-01154976v1
Image document

Ultrasound and microbubble-assisted gene delivery: insights for intracellular mechanism

Anthony Delalande , Spiros Kotopoulis , Patrick Midoux , Michiel Postema , Chantal Pichon et al.
Micro-acoustics in marine and medical research: 1st workshop, Dec 2011, Bergen, Norway. pp.119-130, ⟨10.5281/zenodo.4779438⟩
Conference papers hal-03197797v2
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Investigations of microbubble-cell interactions during the sonoporation process

Anthony Delalande , Patrick Midoux , Chantal Pichon , Spiros Kotopoulis , Michiel Postema et al.
18th International Congress on Sound and Vibration, Rio de Janeiro, Brazil, 10-14 July 2011, Jul 2011, Rio de Janeiro, Brazil
Conference papers hal-03195597v1
Image document

Ultrasound-activated microbubbles for tendon gene transfer: in vivo efficiency and confocal microscopy real time intracellular investigations

Anthony Delalande , Ayache Bouakaz , Patrick Midoux , Michiel Postema , Chantal Pichon et al.
20th International Congress on Acoustics, ICA 2010, Aug 2010, Sydney, Australia. pp.524
Conference papers hal-03195559v1

Mannosylated and Histidylated LPR Technology for Vaccination with Tumor Antigen mRNA

Chantal Pichon , Patrick Midoux
Synthetic Messenger RNA and Cell Metabolism Modulation, pp.247-274, 2013, ⟨10.1007/978-1-62703-260-5_16⟩
Book sections hal-02070913v1

Histidine containing peptides and polypeptides as nucleic acid vectors

P. Midoux , E. Lecam , D. Coulaud , E. Delain , C. Pichon et al.
Luo D., Saltzman W.M. Synthetic DNA Delivery Systems, Kluwer Academic/Plenum Publishers, New-York, pp.23-44, 2003
Book sections hal-00115810v1

Histidylated polycationic molecules for nucleic acids transfer

P. Midoux , C. Pichon
Pandalai S.G. Recent research developments in bioconjugate chemistry, Transworld Research Network, Trivandrum, pp.95-111, 2002
Book sections hal-00115805v1

Glycoconjugates as vectors for gene and oligonucleotide delivery

M. Monsigny , C. Quétard , E. Duverger , C. Pichon , V. Altemayer et al.
Aubery M. Glycans in cellular interaction and recognition: therapeutic, Harwood Academic Publishers, Amsterdam, pp.193-215, 2002
Book sections hal-00115807v1

Peptide-based gene delivery systems

P. Midoux , C. Pichon
Mahato R.I., Kim S.W. Pharmaceutical perspectives of nucleic acid-based, Taylor & Francis, London and New York, pp.334-366, 2002
Book sections hal-00115804v1

Sugar Specific Delivery of Drugs, Oligonucleotides and Genes

M. Monsigny , A.-C. Roche , P. Midoux , R. Mayer
Targeting of drugs4, Springer US, pp.31-50, 1994, 978-1-4899-1209-1
Book sections hal-02163778v1

Endocytosis Analysis by Flow Cytometry : Study of the Endocytosis of Fluoresceinylated Neoglycoproteins Via Membrane Lectins of Macrophages

P. Midoux , A.C Roche , M. Monsigny
Flow cytometry NATO ASI Series, 67, Springer Berlin Heidelberg, pp.49-64, 1993
Book sections hal-02163788v1

Glycosylated Polymers as Carriers for Targeting Antiviral and Antiparasite Drugs

Michel Monsigny , Annie-Claude Roche , Roger Mayer , Patrick Midoux , Eric Negre et al.
Endocytosis - NATO ASI Series, 62, Springer Berlin Heidelberg, pp.489-496, 1992
Book sections hal-02163791v1

Peptide and Carbohydrate Moieties as Molecular Signals in Animal Cell Recognition

M. Monsigny , A.C Roche , C. Kieda , R. Mayer , P. Midoux et al.
Cell to Cell Signals in Plant, Animal and Microbial Symbiosis, Springer Berlin Heidelberg, pp.237-254, 1988
Book sections hal-02163831v1

Wheat Germ Agglutinin: A Review of Recent Results

J.-Ph Grivet , P. Midoux , P. Gatellier , F. Delmotte , M. Monsigny et al.
Structure, Dynamics, Interactions and Evolution of Biological Macromolecules, Springer Netherlands, pp.329-349, 1983
Book sections hal-02163840v1