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Patrick Midoux

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chantal-pichon
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mRNA Lipoplexes with Cationic and Ionizable α-Amino-lipophosphonates: Membrane Fusion, Transfection, mRNA Translation and Conformation

Sohail Akhter , Mathieu Berchel , Paul-Alain Jaffrès , Chantal Pichon , Patrick Midoux
Pharmaceutics, 2022, 14 (3), pp.581. ⟨10.3390/pharmaceutics14030581⟩
Article dans une revue hal-03927316v1
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Intracellular Routing and Recognition of Lipid-Based mRNA Nanoparticles

Christophe Delehedde , Luc Even , Patrick Midoux , Chantal Pichon , Federico Perche
Pharmaceutics, 2021, 13 (7), pp.945. ⟨10.3390/pharmaceutics13070945⟩
Article dans une revue hal-03335664v1
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LentiRILES, a miRNA-ON Sensor System for Monitoring the Functionality of miRNA in Cancer Biology and Therapy

Viorel Simion , Claire Loussouarn , Yoan Laurent , Loris Roncali , David Gosset
RNA Biology/RNA Biol., 2021, Online ahead of print. ⟨10.1080/15476286.2021.1978202⟩
Article dans une revue inserm-03374619v1
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Intracellular trafficking and functional monitoring of miRNA delivery in glioblastoma using lipopolyplexes and the miRNA-ON RILES reporter system

Viorel Simion , Elodie Henriet , Viktorija Juric , Ruth Aquino , Claire Loussouarn
Journal of Controlled Release, 2020, 327, pp.429-443. ⟨10.1016/j.jconrel.2020.08.028⟩
Article dans une revue hal-02959393v1
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Periodic Mesoporous Organosilica Nanoparticles with BOC Group, towards HIFU Responsive Agents

Hao Li , Carolina Gascó , Anthony Delalande , Clarence Charnay , Laurence Raehm
Molecules, 2020, 25 (4), pp.974. ⟨10.3390/molecules25040974⟩
Article dans une revue hal-02544155v1
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Co-delivery of NS1 and BMP2 mRNAs to murine pluripotent stem cells leads to enhanced BMP-2 expression and osteogenic differentiation

Pinpin Wang , Delphine Logeart-Avramoglou , Hervé Petite , Cristine Gonçalves , Patrick Midoux
Acta Biomaterialia, 2020, 108, pp.337-346. ⟨10.1016/j.actbio.2020.03.045⟩
Article dans une revue hal-02553030v1
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Comparative binding and uptake of liposomes decorated with mannose oligosaccharides by cells expressing the mannose receptor or DC-SIGN

Haifei Gao , Cristine Goncalves , Téo Gallego , Marc Francois-Heude , Virginie Malard
Carbohydrate Research, 2020, 487, pp.107877. ⟨10.1016/j.carres.2019.107877⟩
Article dans une revue hal-02522179v1
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Improved histidinylated lPEI polyplexes for skeletal muscle cells transfection

Jean-Pierre Gomez , Guillaume Tresset , Chantal Pichon , Patrick Midoux
International Journal of Pharmaceutics, 2019, 559, pp.58-67. ⟨10.1016/j.ijpharm.2019.01.003⟩
Article dans une revue hal-02067297v1
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Amino-acid functionalized porous silicon nanoparticles for the delivery of pDNA

Arnaud Chaix , Eduardo Cueto-Diaz , Anthony Delalande , Nikola Knezevic , Patrick Midoux
RSC Advances, 2019, 9 (55), pp.31895-31899. ⟨10.1039/c9ra05461h⟩
Article dans une revue hal-02338857v1
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Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety

Kevin van Der Jeught , Stefaan de Koker , Lukasz Bialkowski , Carlo Heirman , Patrick Tjok Joe
ACS Nano, 2018, 12 (10), pp.9815-9829. ⟨10.1021/acsnano.8b00966⟩
Article dans une revue hal-01889829v1

Preclinical evaluation of mRNA trimannosylated lipopolyplexes as therapeutic cancer vaccines targeting dendritic cells

A. Le Moignic , V. Malard , T. Benvegnu , L. Lemiègre , Mathieu Berchel
Journal of Controlled Release, 2018, 278, pp.110 - 121. ⟨10.1016/j.jconrel.2018.03.035⟩
Article dans une revue hal-01774851v1

Effect of IL-1β, TNF-α and IGF-1 on trans-endothelial passage of synthetic vectors through an in vitro vascular endothelial barrier of striated muscle

Jean-Pierre Gomez , Cristine Gonçalves , Chantal Pichon , Patrick Midoux
Gene Therapy, 2017, 24 (7), pp.416 - 424. ⟨10.1038/gt.2017.40⟩
Article dans une revue hal-01618260v1

Nanoporous metal organic frameworks as hybrid polymer–metal composites for drug delivery and biomedical applications

Sarwar Beg , Mahfoozur Rahman , Atul Jain , Sumant Saini , Patrick Midoux
Drug Discovery Today Biosilico, 2017, 22 (4), pp.625-637. ⟨10.1016/j.drudis.2016.10.001⟩
Article dans une revue hal-02068701v1

Bile Salt Stabilized Vesicles (Bilosomes): A Novel Nano-Pharmaceutical Design for Oral Delivery of Proteins and Peptides

Javed Ahmad , Madhur Singhal , Saima Amin , Md. Rizwanullah , Sohail Akhter
Current Pharmaceutical Design, 2017, 23 (11), pp.1575 - 1588. ⟨10.2174/1381612823666170124111142⟩
Article dans une revue hal-01656515v1
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Cationic gas-filled microbubbles for ultrasound-based nucleic acids delivery

Anthony Delalande , Colette Bastié , Lucie Pigeon , Simona Manta , Matthias Lebertre
Bioscience Reports, 2017, 37 (6), pp.BSR20160619. ⟨10.1042/BSR20160619⟩
Article dans une revue hal-02123147v1

Production of DNA minicircles less than 250 base pairs through a novel concentrated DNA circularization assay enabling minicircle design with NF-κB inhibition activity

Thomas Thibault , Jéril Degrouard , Patrick Baril , Chantal Pichon , Patrick Midoux
Nucleic Acids Research, 2017, 45 (5), pp.e26 - e26. ⟨10.1093/nar/gkw1034⟩
Article dans une revue hal-01618796v1

Synthesis of α-amino-lipophosphonates as cationic lipids or co-lipids for DNA transfection in dendritic cells

Mathieu Berchel , Sohail Akhter , Wilfried Berthe , Cristine Gonçalvez , Marine Dubuisson
Journal of materials chemistry‎ B, 2017, J. Mater. Chem. B, 5, pp.6869-6881. ⟨10.1039/C7TB01080J⟩
Article dans une revue hal-01551638v1

Nanotechnology Based Theranostic Approaches in Alzheimer's Disease Management: Current Status and Future Perspective

Javed Ahmad , Sohail Akhter , Md. Rizwanullah , Mohammad Ahmed Khan , Lucie Pigeon
Current Alzheimer Research, 2017, 14 (11), pp.1164-1181. ⟨10.2174/1567205014666170508121031⟩
Article dans une revue hal-02068674v1
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Cationic microbubbles and antibiotic-free miniplasmid for sustained ultrasound–mediated transgene expression in liver

Simona Manta , Gilles Renault , Anthony Delalande , Olivier Couture , Isabelle Lagoutte
Journal of Controlled Release, 2017, 262, pp.170 - 181. ⟨10.1016/j.jconrel.2017.07.015⟩
Article dans une revue hal-01656574v1
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Curcumin/poly(2-methyl-2-oxazoline-b-tetrahydrofuran-b-2-methyl-2-oxazoline) formulation: An improved penetration and biological effect of curcumin in F508del-CFTR cell lines

Cristine Gonçalves , Pierre Gomez , William Même , Bazoly Rasolonjatovo , David Gosset
European Journal of Pharmaceutics and Biopharmaceutics, 2017, 117, pp.168-181. ⟨10.1016/j.ejpb.2017.04.015⟩
Article dans une revue hal-01618274v1

Peptides mediating DNA transport on microtubules and their impact on non-viral gene transfer efficiency

Patrick Midoux , Lucie Pigeon , Cristine Goncalves , Chantal Pichon
Bioscience Reports, 2017, 37 (5), pp.BSR20170995. ⟨10.1042/BSR20170995⟩
Article dans une revue hal-02068759v1

Toxicity of Inorganic Nanoparticles Used in Targeted Drug Delivery and Other Biomedical Application: An Updated Account on Concern of Biomedical Nanotoxicology

Mohammad Zaki Ahmad , Basel Abdel-Wahab , Afroze Alam , Sobiya Zafar , Javed Ahmad
Journal of Nanoscience and Nanotechnology, 2016, 16 (8), pp.7873-7897. ⟨10.1166/jnn.2016.13032⟩
Article dans une revue hal-02519256v1

Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines

Thomas Démoulins , Panagiota Milona , Pavlos C. Englezou , Thomas Ebensen , Kai Schulze
Nanomedicine: Nanotechnology, Biology and Medicine, 2016, 12 (3), pp.711 - 722. ⟨10.1016/j.nano.2015.11.001⟩
Article dans une revue hal-01406947v1

Engineered Nanoparticles Against MDR in Cancer: The State of the Art and its Prospective

Javed Ahmad , Sohail Akhter , Mohammad Ahmed Khan , Muhammad Wahajuddin , Nigel H. Greig
Current Pharmaceutical Design, 2016, 22 (28), pp.4360-4373. ⟨10.2174/1381612822666160617112111⟩
Article dans une revue hal-02068807v1

Evidence for plasmid DNA exchange after polyplex mixing

L. Pigeon , C. Gonçalves , C. Pichon , P. Midoux
Soft Matter, 2016, 12 (33), pp.7012-7019. ⟨10.1039/c6sm00575f⟩
Article dans une revue hal-02069106v1

Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes

J. Barbeau , L. Lemiègre , A. Quelen , V. Malard , H. Gao
Carbohydrate Research, 2016, 435, pp.142--148. ⟨10.1016/j.carres.2016.10.003⟩
Article dans une revue hal-01398046v1

Intracellular Availability of pDNA and mRNA after Transfection: A Comparative Study among Polyplexes, Lipoplexes, and Lipopolyplexes

Cristine Goncalves , Sohail Akhter , Chantal Pichon , Patrick Midoux
Molecular Pharmaceutics, 2016, 13 (9), pp.3153-3163. ⟨10.1021/acs.molpharmaceut.6b00376⟩
Article dans une revue hal-02069071v1

Lipid-based mRNA vaccine delivery systems

Patrick Midoux , Chantal Pichon
Expert Review of Vaccines, 2015, 14 (2), pp.221-234. ⟨10.1586/14760584.2015.986104⟩
Article dans une revue hal-01171750v1

Enhanced Achilles tendon healing by fibromodulin gene transfer

Anthony Delalande , Marie-Pierre Gosselin , Arnaud Suwalski , William Guilmain , Chloé Leduc
Nanomedicine: Nanotechnology, Biology and Medicine, 2015, 11 (7), pp.1735 - 1744. ⟨10.1016/j.nano.2015.05.004⟩
Article dans une revue hal-01537597v1

Gene delivery efficiency and intracellular trafficking of novel poly(allylamine) derivatives

Magdalena Wytrwal , Chloe Leduc , Michal Sarna , Cristine Goncalves , Mariusz Kepczynski
International Journal of Pharmaceutics, 2015, 478 (1), pp.372-382. ⟨10.1016/j.ijpharm.2014.11.053⟩
Article dans une revue hal-01172009v1
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Efficient gene delivery by sonoporation is associated with microbubble entry into cells and the clathrin-dependent endocytosis pathway

Anthony Delalande , Chloe Leduc , Patrick Midoux , Michiel Postema , Chantal Pichon
Ultrasound in Medicine & Biology, 2015, 41 (7), pp.1913-1926. ⟨10.1016/j.ultrasmedbio.2015.03.010⟩
Article dans une revue hal-03198520v1

Synthetic vectors for gene delivery: An overview of their evolution depending on routes of administration

Nawal Belmadi , Patrick Midoux , Pascal Loyer , Catherine Passirani , Chantal Pichon
Biotechnology Journal, 2015, 10 (9), pp.1370-1389. ⟨10.1002/biot.201400841⟩
Article dans une revue hal-01162373v1

Improved gene transfer with histidine-​functionalized mesoporous silica nanoparticles

David Brevet , Ouahiba Hocine , Anthony Delalande , Laurence Raehm , Clarence Charnay
International Journal of Pharmaceutics, 2014, pp.197-205. ⟨10.1016/j.ijpharm.2014.05.020⟩
Article dans une revue hal-01068026v1

Editorial: Current status and prospects on nucleic acid transfer

Tristan Montier , Chantal Pichon , Marc Blondel , Patrick Midoux
Biotechnology Journal, 2014, 9 (11), pp.1363-1364. ⟨10.1002/biot.201300510⟩
Article dans une revue hal-02135170v1

Improved nuclear delivery of antisense 2′-Ome RNA by conjugation with the histidine-rich peptide H5WYG

Ulysse Asseline , Cristine Gonçalves , Chantal Pichon , Patrick Midoux
The Journal of Gene Medicine, 2014, 16 (7-8), pp.157-165. ⟨10.1002/jgm.2773⟩
Article dans une revue hal-01175483v1

Influence of pDNA availability on transfection efficiency of polyplexes in non-proliferative cells.

Benoit Maury , Cristine Gonçalves , Guillaume Tresset , Mehdi Zeghal , Hervé Cheradame
Biomaterials, 2014, 35 (22), pp.5977-5985. ⟨10.1016/j.biomaterials.2014.04.007⟩
Article dans une revue hal-01179393v1

Lipopolyplexes comprising imidazole/imidazolium lipophosphoramidate, histidinylated polyethyleneimine and siRNA as efficient formulation for siRNA transfection

Cristine Gonçalves , Mathieu Berchel , Marie-Pierre Gosselin , Virginie Malard , Hervé Cheradame
International Journal of Pharmaceutics, 2014, 460 (1-2), pp.264-272. ⟨10.1016/j.ijpharm.2013.11.005⟩
Article dans une revue hal-01179049v1

NF-kB related transgene expression in mouse tibial cranial muscle after pDNA injection followed or not by electrotransfer.

S Mahindhoratep , H Ait Bouda , Nelly El Shafey , D Scherman , A Kichler
BBA - Biochimica et Biophysica Acta, 2014, 1840 (11), pp.3257-3263
Article dans une revue hal-01179311v1

An E3-14.7K Peptide that Promotes Microtubules-Mediated Transport of Plasmid DNA Increases Polyplexes Transfection Efficiency.

Lucie Pigeon , Cristine Gonçalves , David Gosset , Chantal Pichon , Patrick Midoux
Small, 2013, 9 (22), pp.3845-3851. ⟨10.1002/smll.201300217⟩
Article dans une revue hal-00840172v1

Ability of plasmid DNA complexed with histidinylated lPEI and lPEI to cross in vitro lung and muscle vascular endothelial barriers

Jean-Pierre Gomez , Chantal Pichon , Patrick Midoux
Gene, 2013, 525 (2), pp.182-190. ⟨10.1016/j.gene.2013.03.055⟩
Article dans une revue hal-02070843v1
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Exogenous mRNA delivery and bioavailability in gene transfer mediated by piggyBac transposition

Solenne Bire , David Gosset , Gwenhael Jegot , Patrick Midoux , Chantal Pichon
BMC Biotechnology, 2013, 13, pp.1-15. ⟨10.1186/1472-6750-13-75⟩
Article dans une revue hal-01129780v1
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Sonoporation: mechanistic insights and ongoing challenges for gene transfer

Anthony Delalande , Spiros Kotopoulis , Michiel Postema , Patrick Midoux , Chantal Pichon
Gene, 2013, 525 (2), pp.191-199. ⟨10.1016/j.gene.2013.03.095⟩
Article dans une revue hal-03195625v1

RILES, a novel method for temporal analysis of the in vivo regulation of miRNA expression.

Safia Ezzine , Georges Vassaux , Bruno Pitard , Benoit Barteau , Jean-Marc Malinge
Nucleic Acids Research, 2013, epub ahead of print. ⟨10.1093/nar/gkt797⟩
Article dans une revue hal-00874881v1

Gene transfer by chemical vectors, and endocytosis routes of polyplexes, lipoplexes and lipopolyplexes in a myoblast cell line.

Ludivine Billiet , Jean-Pierre Gomez , Mathieu Berchel , Paul-Alain Jaffres , Tony Le Gall
Biomaterials, 2012, 33 (10), pp.2980-2990. ⟨10.1016/j.biomaterials.2011.12.027⟩
Article dans une revue hal-00721795v1
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Ultrasound and microbubble-assisted gene delivery: recent advances and ongoing challenges

Anthony Delalande , Michiel Postema , Nathalie Mignet , Patrick Midoux , Chantal Pichon
Therapeutic Delivery, 2012, 3 (10), pp.1199-1215. ⟨10.4155/TDE.12.100⟩
Article dans une revue hal-03193228v1
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Gene transfer by histidylated lipopolyplexes: A dehydration method allowing preservation of their physicochemical parameters and transfection efficiency

Federico Perche , Olivier Lambert , Mathieu Berchel , Paul-Alain Jaffres , Chantal Pichon
International Journal of Pharmaceutics, 2012, 423 (1), pp.144 - 150. ⟨10.1016/j.ijpharm.2011.04.009⟩
Article dans une revue hal-02995807v1

Ultrasound and microbubble-assisted gene delivery: recent advances and ongoing challenges.

Anthony Delalande , Michiel Postema , Nathalie Mignet , Patrick Midoux , Chantal Pichon
Ther Deliv, 2012, 3 (10), pp.1199-1215
Article dans une revue hal-00817350v1

Supramolecular assemblies of histidinylated α-cyclodextrin in the presence of DNA scaffold during CDplexes formation.

Véronique Bennevault-Celton , Allan Urbach , Olivier Martin , Chantal Pichon , Philippe Guégan
Bioconjugate Chemistry, 2011, 22 (12), pp.2404-14. ⟨10.1021/bc200167p⟩
Article dans une revue hal-00720527v1

Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer.

Emilie Bertrand , Cristine Gonçalves , Ludivine Billiet , Jean Pierre Gomez , Chantal Pichon
Chemical Communications, 2011, 47 (46), pp.12547-12549. ⟨10.1039/c1cc15716g⟩
Article dans une revue hal-00720539v1
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Ultrasound and microbubble-assisted gene delivery in Achilles tendons: long lasting gene expression and restoration of fibromodulin KO phenotype

Anthony Delalande , Ayache Bouakaz , Gilles Renault , Flore Tabareau , Spiros Kotopoulis
Journal of Controlled Release, 2011, 156 (2), pp.223-230. ⟨10.1016/j.jconrel.2011.08.020⟩
Article dans une revue hal-03195121v1

Selective gene delivery in dendritic cells with mannosylated and histidylated lipopolyplexes.

Federico Perche , David Gosset , Mathieu Mével , Marie-Laure Miramon , Jean-Jacques Yaouanc
Journal of Drug Targeting, 2011, 19 (5), pp.315-25. ⟨10.3109/1061186X.2010.504262⟩
Article dans une revue hal-00753554v1

Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA.

Federico Perche , Thierry Benvegnu , Mathieu Berchel , Loic Lebegue , Chantal Pichon
Nanomedicine: Nanotechnology, Biology and Medicine, 2011, 7 (4), pp.445-53. ⟨10.1016/j.nano.2010.12.010⟩
Article dans une revue hal-00754373v1

Chemical vectors for gene delivery: uptake and intracellular trafficking

Chantal Pichon , Ludivine Billiet , Patrick Midoux
Current Opinion in Biotechnology, 2010, 21 (5), pp.640-645. ⟨10.1016/j.copbio.2010.07.003⟩
Article dans une revue hal-00602488v1

Ultrasound-assisted microbubbles gene transfer in tendons for gene therapy

Anthony Delalande , Michel-Francis Bureau , Patrick Midoux , Ayache Bouakaz , Chantal Pichon
Ultrasonics Sonochemistry, 2010, 50 (2), pp.269-272. ⟨10.1016/j.ultras.2009.09.035⟩
Article dans une revue hal-00529321v1

Uptake of Functionalized Mesoporous Silica Nanoparticles by Human Cancer Cells

Matthieu Fisichella , Hinda Dabboue , Sanjib Bhattacharyya , Gerald Lelong , Marie-Louise Saboungi
Journal of Nanoscience and Nanotechnology, 2010, 10 (4), pp.314-2324. ⟨10.1166/jnn.2010.1917⟩
Article dans une revue hal-00529333v1

Transient transmembrane release of green fluorescent proteins with sonoporation

K. Kaddur , L. Lebegue , F. Tranquart , P. Midoux , C. Pichon
IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 2010, 57 (7), pp.1558-1567. ⟨10.1109/TUFFC.2010.1586⟩
Article dans une revue hal-00529340v1
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Accelerated Achilles tendon healing by PDGF gene delivery with mesoporous silica nanoparticles

Arnaud Suwalski , Hinda Dabboue , Anthony Delalande , Sabine F. Bensamoun , Francis Canon
Biomaterials, 2010, 31 (19), pp.5237-5245. ⟨10.1016/j.biomaterials.2010.02.077⟩
Article dans une revue hal-00529475v1

Histidine-rich peptide: evidence for a single zinc-binding site on H5WYG peptide that promotes membrane fusion at neutral pH

Corinne Bure , Régine Maget , Agnès F. Delmas , Chantal Pichon , Patrick Midoux
Journal of Mass Spectrometry, 2009, 44 (1), pp.81-89. ⟨10.1002/jms.1473⟩
Article dans une revue hal-00521834v1

An optimized extended DNA kappa B site that enhances plasmid DNA nuclear import and gene expression

Cristine Gonçalves , Maryvonne Ardourel , Martine Decoville , Gilles Breuzard , Patrick Midoux
The Journal of Gene Medicine, 2009, 11 (5), pp.401-411. ⟨10.1002/jgm.1312⟩
Article dans une revue hal-00522437v1
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Comparative gene transfer between cationic and thiourea lipoplexes

Marie Breton , Jeanne Leblond , Johanne Seguin , Patrick Midoux , Daniel Scherman
The Journal of Gene Medicine, 2009, 12 (1), pp.45-54. ⟨10.1002/jgm.1417⟩
Article dans une revue hal-02512540v1

Involvement of histidines 11, 15 and 19 in the binding of zinc to the fusogenic H5WYG peptide

Corinne Bure , Chantal Pichon , Patrick Midoux
Journal of Mass Spectrometry, 2009, 44 (8), pp.1163-1170. ⟨10.1002/jms.1591⟩
Article dans une revue hal-00521851v1

Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers

Patrick Midoux , Chantal Pichon , Jean-Jacques Yaouanc , Paul-Alain Jaffres
British Journal of Pharmacology, 2009, 157 (2), pp.166-178. ⟨10.1111/j.1476-5381.2009.00288.x⟩
Article dans une revue hal-00525108v1
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Cationic Lipids Based on Phosphonate and Phosphoramidate Chemistry: Synthesis and Application to Gene Therapy

Mathieu Mével , Jean-Jacques Yaouanc , Pascal Laurent , Claude Clément , Dominique Cartier
Phosphorus, Sulfur, and Silicon and the Related Elements, 2008, 183 (2-3), pp.460-468. ⟨10.1080/10426500701761300⟩
Article dans une revue hal-01580434v1

Extraction of green fluorescent proteins with sonoporation

Kadija Kaddur , Anthony Delalande , François Tranquart , Patrick Midoux , Chantal Pichon
Journal of the Acoustical Society of America, 2008, 123 (5), pp.3218-3218. ⟨10.1121/1.2933412⟩
Article dans une revue hal-02128161v1

Recent advances in gene delivery with ultrasound and microbubbles

Chantal Pichon , Kadija Kaddur , Patrick Midoux , François Tranquart , Ayache Bouakaz
Journal of Experimental Nanoscience, 2008, 3 (1), pp.17-40. ⟨10.1080/17458080801993422⟩
Article dans une revue hal-00518203v1

Nuclear delivery of NFkappaB-assisted DNA/polymer complexes: plasmid DNA quantitation by confocal laser scanning microscopy and evidence of nuclear polyplexes by FRET imaging.

Gilles Breuzard , Magdalena Tertil , Cristine Gonçalves , Hervé Cheradame , Philippe Géguan
Nucleic Acids Research, 2008, 36 (12), pp.e71. ⟨10.1093/nar/gkn287⟩
Article dans une revue hal-00408004v1

Synthesis and transfection activity of new cationic phosphoramidate lipids: High efficiency of an imidazolium derivative

M. Mevel , Gilles Breuzard , J.-J. Yaouanc , J.-C. Clement , P. Lehn
ChemBioChem, 2008, 9 (9), pp.1462-1471. ⟨10.1002/cbic.200700727⟩
Article dans une revue hal-00518184v1

Polymer-Based Gene Delivery: A Current Review on the Uptake and Intracellular Trafficking of Polyplexes

Patrick Midoux , Gilles Breuzard , Jean-Pierre Gomez , Chantal Pichon
Current Gene Therapy, 2008, 8 (5), pp.335-352
Article dans une revue hal-00518197v1

Novel neutral imidazole-lipophosphoramides for transfection assays

M. Mevel , C. Neveu , Cristine Goncalves , J.-J. Yaouanc , Chantal Pichon
Chemical Communications, 2008, 27, pp.3124-3126. ⟨10.1039/b805226c⟩
Article dans une revue hal-00518192v1

mRNA-based cancer vaccine: prevention of B16 melanoma progression and metastasis by systemic injection of MART1 mRNA histidylated lipopolyplexes.

M. Mockey , E. Bourseau , V. Chandrashekhar , A. Chaudhuri , S. Lafosse
Cancer Gene Therapy, 2007, 14 (9), pp.802-14. ⟨10.1038/sj.cgt.7701072⟩
Article dans une revue hal-00318514v1

mRNA-based cancer vaccine: prevention of B16 melanoma progression and metastasis by systemic injection of MART1 mRNA histidylated lipopolyplexes

M. Mockey , E Bourseau , V Chandrashekhar , A. Chaudhuri , S. Lafosse
Cancer Gene Therapy, 2007, 14 (9), pp.802-814. ⟨10.1038/sj.cgt.7701072⟩
Article dans une revue hal-03065277v1

Intracellular trafficking and nuclear import of polyplexes by FRET coupled with cellular imaging

Gilles Breuzard , M. Tertil , Chantal Pichon , Patrick Midoux
Human Gene Therapy, 2007, 18, pp.1048
Article dans une revue hal-00275215v1

DNA/cationic polymer complex attachment on a human vascular endothelial cell monolayer exposed to a steady laminar flow

Eric Mennesson , Patrick Erbacher , Mateusz Kuzak , Claudine Kieda , Patrick Midoux
Journal of Controlled Release, 2006, 114 (3), pp.389-397. ⟨10.1016/j.jconrel.2006.06.006⟩
Article dans une revue hal-00112894v1

mRNA transfection of dendritic cells: synergistic effect of ARCA mRNA capping with Poly(A) chains in cis and in trans for a high protein expression level

M. Mockey , C. Goncalves , F.P. Dupuy , F.M. Lemoine , C. Pichon
Biochemical and Biophysical Research Communications, 2006, 340, pp.1062-1068. ⟨10.1016/j.bbrc.2005.12.105⟩
Article dans une revue hal-00088921v1

Transfection efficiency and uptake process of polyplexes in human lung endothetial cells: a comparative study in non-polarized and polarized cells

E. Mennesson , P. Erbacher , V. Piller , C. Kieda , P. Midoux
The Journal of Gene Medicine, 2005, 7, pp.729-738
Article dans une revue hal-00088642v1

Non-viral vectors in cystic fibrosis gene therapy: progress and challenges

T. Montier , P. Delépine , C. Pichon , C. Férec , D.J. Porteous
Trends in biotechnology., 2004, 22, pp.586-592
Article dans une revue hal-00088424v1

Macropinocytosis of polyplexes and recycling of plasmid via the clathrin-dependant pathway impair the transfection efficiency into human hepatocarcinoma cells

C. Goncalves , E. Mennesson , R. Fuchs , Gorvel J.P. , Patrick Midoux
Molecular Therapy, 2004, 10, pp.373-385
Article dans une revue hal-00113047v1

Optimization of in vitro vascular cell transfection with non-viral vectors for in vivo applications

Ibrahim Elmadbouh , Patrick Rossignol , Olivier Meilhac , Roger Vranckx , Chantal Pichon
The Journal of Gene Medicine, 2004, 6 (10), pp.1112-1124
Article dans une revue hal-00014241v1

On the gene delivery efficacies of pH-sensitive cationic lipids via endosomal protonation: a chemical biology investigation

R.S. Singh , C. Gonçalves , P. Sandrin , C. Pichon , P. Midoux
Chemistry & biology, 2004, 11, pp.713-723
Article dans une revue hal-00088426v1

Poly[Lys-(AEDTP)]: A Cationic Polymer That Allows Dissociation of pDNA/Cationic Polymer Complexes in a Reductive Medium and Enhances Polyfection

Chantal Pichon , Eric Le Cam , Brigitte Guérin , Dominique Coulaud , Etienne Delain
Bioconjugate Chemistry, 2002, 13 (1), pp.76-82. ⟨10.1021/bc015503o⟩
Article dans une revue hal-03065338v1

Intracellular processing and stability of DNA complexed with histidylated polylysine conjugates

Christine Gonçalves , Chantal Pichon , Brigitte Guérin , Patrick Midoux
The Journal of Gene Medicine, 2002, 4 (3), pp.271-281. ⟨10.1002/jgm.277⟩
Article dans une revue hal-02135970v1

Zinc improves gene transfer mediated by DNA/cationic polymer complexes

Chantal Pichon , Brigitte Guérin , Matthieu M. Refregiers , Christine Gonçalves , Paul Vigny
The Journal of Gene Medicine, 2002, 4 (5), pp.548 - 559. ⟨10.1002/jgm.303⟩
Article dans une revue hal-01596013v1

Single histidine residue in head-group region is sufficient to impart remarkable gene transfection properties to cationic lipids: evidence for histidine-mediated membrane fusion at acidic pH

V Kumar , Chantal Pichon , M. Refregiers , B Guerin , P. Midoux
Gene Therapy, 2002, 10 (15), pp.1206 - 1215. ⟨10.1038/sj.gt.3301979⟩
Article dans une revue hal-01596052v1

Histidine containing peptides and polypeptides as nucleic acid vectors.

Patrick Midoux , Eric Le Cam , Dominique Coulaud , Etienne Delain , Chantal Pichon
Somatic Cell and Molecular Genetics, 2002, 27 (1-6), pp.27-47. ⟨10.1023/a:1022931923153⟩
Article dans une revue hal-03065331v1

Histidine-rich peptides and polymers for nucleic acids delivery.

Chantal Pichon , C Gonçalves , P. Midoux
Advanced Drug Delivery Reviews, 2001, 53 (1), pp.75-94
Article dans une revue hal-02135973v1

Histidylated oligolysines increase the transmembrane passage and the biological activity of antisense oligonucleotides

Chantal Pichon , Mahajoub Bello Roufaï , Michel Monsigny , Patrick Midoux
Nucleic Acids Research, 2000, 28 (2), pp.504-512. ⟨10.1093/nar/28.2.504⟩
Article dans une revue hal-02135979v1

Histidylated polylysine as a synthetic vector for gene transfer into immortalized cystic fibrosis airway surface and airway gland serous cells

Isabelle Fajac , J.C Allo , Evelyne Souil , Marc Merten , Chantal Pichon
The Journal of Gene Medicine, 2000, 2 (5), pp.368-378. ⟨10.1002/1521-2254(200009/10)2:5<368::AID-JGM118>3.0.CO;2-F⟩
Article dans une revue hal-02135988v1

Glycotargeting: the preparation of glyco-amino acids and derivatives from unprotected reducing sugars.

M Monsigny , C. Quétard , S. Bourgerie , D. Delay , Chantal Pichon
Biochimie, 1998, 80 (2), pp.99-108
Article dans une revue hal-02136005v1

Fluorescent labelling of unmodified phosphorothioate oligodeoxynucleotides: Synthesis and characterization

A.J. Stewart , Chantal Pichon , Patrick Midoux , R. Mayer , Michel Monsigny
New Journal of Chemistry, 1997, 21 (1), pp.87-98
Article dans une revue hal-02161369v1

Cytosolic and Nuclear Delivery of Oligonucleotides Mediated by an Amphiphilic Anionic Peptide

Chantal Pichon , Isabelle Freulon , Patrick Midoux , Roger Mayer , Michel Monsigny
Antisense and Nucleic Acid Drug Development, 1997, 7 (4), pp.335-343. ⟨10.1089/oli.1.1997.7.335⟩
Article dans une revue hal-02136009v1

Enhanced biological activity of antisense oligonucleotides complexed with glycosylated poly-L-lysine.

A. Stewart , Chantal Pichon , L Meunier , P Midoux , M. Monsigny
Molecular Pharmacology, 1996, 50 (6), pp.1487-94
Article dans une revue hal-02136015v1

Influence of the charge of mRNA mannosylated lipopolyplexes on the binding and uptake by dendritic cells

C Delehedde , G Haifei , C Gonçalves , Virginie Malard , N Rameix
33e colloque Biotechnocentre, Oct 2021, Seillac, France
Communication dans un congrès hal-03668427v1

High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells

N Laroui , C Delehedde , C Goncalves , F Godin , Federico Perche
SFNano 2021, Dec 2021, Angers, France
Communication dans un congrès hal-03668422v1
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Positively charged microbubbles to target nucleic acid delivery with ultrasound

Simona Manta , Anthony Delalande , Gilles Renault , Michel Francis Bureau , Matthias Lebertre
Journées RITS 2015, Mar 2015, Dourdan, France
Communication dans un congrès inserm-01154976v1
Image document

Ultrasound and microbubble-assisted gene delivery: insights for intracellular mechanism

Anthony Delalande , Spiros Kotopoulis , Patrick Midoux , Michiel Postema , Chantal Pichon
Micro-acoustics in marine and medical research: 1st workshop, Dec 2011, Bergen, Norway. pp.119-130, ⟨10.5281/zenodo.4779438⟩
Communication dans un congrès hal-03197797v2
Image document

Investigations of microbubble-cell interactions during the sonoporation process

Anthony Delalande , Patrick Midoux , Chantal Pichon , Spiros Kotopoulis , Michiel Postema
18th International Congress on Sound and Vibration, Rio de Janeiro, Brazil, 10-14 July 2011, Jul 2011, Rio de Janeiro, Brazil
Communication dans un congrès hal-03195597v1
Image document

Ultrasound-activated microbubbles for tendon gene transfer: in vivo efficiency and confocal microscopy real time intracellular investigations

Anthony Delalande , Ayache Bouakaz , Patrick Midoux , Michiel Postema , Chantal Pichon
20th International Congress on Acoustics, ICA 2010, Aug 2010, Sydney, Australia. pp.524
Communication dans un congrès hal-03195559v1

Mannosylated and Histidylated LPR Technology for Vaccination with Tumor Antigen mRNA

Chantal Pichon , Patrick Midoux
Synthetic Messenger RNA and Cell Metabolism Modulation, pp.247-274, 2013, ⟨10.1007/978-1-62703-260-5_16⟩
Chapitre d'ouvrage hal-02070913v1

Histidine containing peptides and polypeptides as nucleic acid vectors

P. Midoux , E. Lecam , D. Coulaud , E. Delain , C. Pichon
Luo D., Saltzman W.M. Synthetic DNA Delivery Systems, Kluwer Academic/Plenum Publishers, New-York, pp.23-44, 2003
Chapitre d'ouvrage hal-00115810v1

Histidylated polycationic molecules for nucleic acids transfer

P. Midoux , C. Pichon
Pandalai S.G. Recent research developments in bioconjugate chemistry, Transworld Research Network, Trivandrum, pp.95-111, 2002
Chapitre d'ouvrage hal-00115805v1

Glycoconjugates as vectors for gene and oligonucleotide delivery

M. Monsigny , C. Quétard , E. Duverger , C. Pichon , V. Altemayer
Aubery M. Glycans in cellular interaction and recognition: therapeutic, Harwood Academic Publishers, Amsterdam, pp.193-215, 2002
Chapitre d'ouvrage hal-00115807v1

Peptide-based gene delivery systems

P. Midoux , C. Pichon
Mahato R.I., Kim S.W. Pharmaceutical perspectives of nucleic acid-based, Taylor & Francis, London and New York, pp.334-366, 2002
Chapitre d'ouvrage hal-00115804v1