Patrick Vourc'h Professeur des Universités-Praticien Hospitalier, Université de Tours, Faculté de médecine, CHU de Tours, Hôpital Bretonneau

Identifiants chercheurs

IdHAL :

patrick-vourch

ORCID :

0000-0001-7960-8139

Publications

Article dans une revue (78)

Intracerebral drug delivery using microbubble/nanodroplet-assisted ultrasound to address neurodegenerative diseases Karen Ea,Nicolas Taulier,Christiane Contino-Pépin,Wladimir Urbach,Stéphane Desgrangeset al. Journal of Clinical and Translational Research, 2025, pp.00061. ⟨10.36922/jctr.24.00061⟩ Article dans une revue hal-04974610v1
MAPT mutations in amyotrophic lateral sclerosis: clinical, neuropathological and functional insights Sibylle de Bertier,Géraldine Lautrette,Maria-Del-Mar Amador,Tomoko Miki,Séverine Boilléeet al. Journal of Neurology, 2025, 272, pp.272. ⟨10.1007/s00415-025-13007-1⟩ Article dans une revue hal-05008980v1
Metabolomic and Proteomic Profiling of Serum-Derived Extracellular Vesicles from Early-Stage Amyotrophic Lateral Sclerosis Patients Yara Al Ojaimi,Nicolas Vallet,Audrey Dangoumau,Débora Lanznaster,Clement Brunoet al. Journal of Molecular Neuroscience, 2025, 75, pp.21. ⟨10.1007/s12031-025-02315-w⟩ Article dans une revue hal-05582450v1
Gut metabolomic and microbiota analyses in ALS mice reveal specific metabolites despite the absence of significant gut dysbiosis Charlotte Veyrat-Durebex,Samira Osman,Yara Al Ojaimi,Philippe Gosset,Camille Dupuyet al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2025, 26 (3-4), pp.368-374. ⟨10.1080/21678421.2024.2433578⟩ Article dans une revue hal-04877256v1
PFMG2025–integrating genomic medicine into the national healthcare system in France Caroline Abadie,Aldja Abderrahmane,Ouarda Abdous,Carine Abel,Oanez Ackermannet al. The Lancet Regional Health - Europe, 2025, 50, pp.101183. ⟨10.1016/j.lanepe.2024.101183⟩ Article dans une revue hal-04988732v1
Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data Sara Saez-Atienzar,Cleide dos Santos Souza,Ruth Chia,Selina Beal,Ileana Lorenziniet al. Cell Genomics, 2024, 4 (11), pp.100679. ⟨10.1016/j.xgen.2024.100679⟩ Article dans une revue hal-04921891v1
PET Study of Microglial Activation in Kleine-Levin Syndrome Lucie Barateau,Anis Krache,Alexandre da Costa,Michel Lecendreux,Sofiene Cheniniet al. Neurology Neuroimmunology & Neuroinflammation, 2024, 11 (4), pp.e200263. ⟨10.1212/NXI.0000000000200263⟩ Article dans une revue hal-04615146v1
N-Terminal Fragments of TDP-43—In Vitro Analysis and Implication in the Pathophysiology of Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration Anna Chami,Léa Bedja-Iacona,Elodie Richard,Debora Lanznaster,Sylviane Marouillatet al. Genes, 2024, 15 (9), pp.1157. ⟨10.3390/genes15091157⟩ Article dans une revue hal-04755409v1
Microglia Density and Its Association With Disease Duration, Severity, and Orexin Levels in Patients With Narcolepsy Type 1 Lucie Barateau,Anis Krache,Alexandre da Costa,Michel Lecendreux,Rachel Debset al. Neurology, 2024, 102 (10), ⟨10.1212/WNL.0000000000209326⟩ Article dans une revue hal-04561871v1
Pharmacometabolomics applied to low-dose interleukin-2 treatment in amyotrophic lateral sclerosis Hugo Alarcan,Clément Bruno,Patrick Emond,Cédric Raoul,Patrick Vourc’het al. Annals of the New York Academy of Sciences, 2024, 1536 (1), pp.82-91. ⟨10.1111/nyas.15147⟩ Article dans une revue hal-04767126v1
French National Protocol for genetic of amyotrophic lateral sclerosis P. Corcia,Patrick Vourc’h,E. Bernard,J. Cassereau,P. Codronet al. Revue Neurologique, 2023, 179 (9), pp.1020-1029. ⟨10.1016/j.neurol.2023.05.005⟩ Article dans une revue hal-04456548v1
Study of Ubiquitin Pathway Genes in a French Population with Amyotrophic Lateral Sclerosis: Focus on HECW1 Encoding the E3 Ligase NEDL1 Shanez Haouari,Christian R Andres,Debora Lanznaster,Sylviane Marouillat,Céline Brulardet al. International Journal of Molecular Sciences, 2023, 24 (2), pp.1268. ⟨10.3390/ijms24021268⟩ Article dans une revue hal-04541653v1
Taking Advantages of Blood–Brain or Spinal Cord Barrier Alterations or Restoring Them to Optimize Therapy in ALS? Hugo Alarcan,Yara Al Ojaimi,Debora Lanznaster,Jean-Michel Escoffre,Philippe Corciaet al. Journal of Personalized Medicine, 2022, 12, pp.1071. ⟨10.3390/jpm12071071⟩ Article dans une revue inserm-03723283v1
Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis Ahmad Al Khleifat,Alfredo Iacoangeli,Joke van Vugt,Harry Bowles,Matthieu Moisseet al. npj Genomic Medicine, 2022, 7 (1), pp.8. ⟨10.1038/s41525-021-00267-9⟩ Article dans une revue hal-03939759v1
Reply to the letter from Gazulla et al. Philippe Corcia,Christian Lunetta,Philippe Couratier,Patrick Vourc’h,Marta Gromichoet al. European Journal of Neurology, 2022, 29 (1), ⟨10.1111/ene.15134⟩ Article dans une revue hal-03521270v1
Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS Paul Hop,Ramona Zwamborn,Eilis Hannon,Gemma Shireby,Marta Nabaiset al. Science Translational Medicine, 2022, 14 (633), pp.eabj0264. ⟨10.1126/scitranslmed.abj0264⟩ Article dans une revue hal-03939741v1
The future of ALS might move towards Genetic Therapy Philippe Corcia,Philippe Couratier,Patrick Vourc’h Revue Neurologique, 2021, 177 (6), pp.613-614. ⟨10.1016/j.neurol.2021.01.007⟩ Article dans une revue hal-03332250v1
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology Wouter van Rheenen,Rick van der Spek,Mark Bakker,Joke J.F.A. van Vugt,Paul J Hopet al. Nature Genetics, 2021, 53 (12), pp.1636-1648. ⟨10.1038/s41588-021-00973-1⟩ Article dans une revue hal-03939733v1
Impact of a frequent nearsplice SOD1 variant in Amyotrophic Lateral Sclerosis: optimizing SOD1 genetic screening for gene therapy opportunities François Muratet,Elisa Teyssou,Aude Chiot,Séverine Boillée,Christian S Lobsigeret al. Journal of Neurology, Neurosurgery and Psychiatry, 2021, 92 (9), pp.942-949. ⟨10.1136/jnnp-2020-325921⟩ Article dans une revue hal-03353407v1
Familial clustering of primary lateral sclerosis and amyotrophic lateral sclerosis: Supplementary evidence for a continuum Philippe Corcia,Christian Lunetta,Philippe Couratier,Patrick Vourc’h,Marta Gromichoet al. European Journal of Neurology, 2021, 28 (8), pp.2780-2783. ⟨10.1111/ene.14960⟩ Article dans une revue hal-03390641v1
Primary Lateral Sclerosis: Clinical, radiological and molecular features P. Bede,P.-F. Pradat,J. Lope,Patrick Vourc’h,Hélène Blascoet al. Revue Neurologique, 2021, ⟨10.1016/j.neurol.2021.04.008⟩ Article dans une revue hal-03284185v1
Effect of familial clustering in the genetic screening of 235 French ALS families Philippe Corcia,William Camu,Celine Brulard,Sylviane Marouillat,Philippe Couratieret al. Journal of Neurology, Neurosurgery and Psychiatry, 2021, 92 (5), pp.479-484. ⟨10.1136/jnnp-2020-325064⟩ Article dans une revue hal-03369962v1
Genes containing hexanucleotide repeats resembling C9ORF72 and expressed in the central nervous system are frequent in the human genome Patrick Vourc’h,François Wurmser,Céline Brulard,Kevin Mouzat,Sandra Kassemet al. Neurobiology of Aging, 2021, 97, pp.148.e1 - 148.e7. ⟨10.1016/j.neurobiolaging.2020.07.027⟩ Article dans une revue hal-03493473v1
The Effect of SMN Gene Dosage on ALS Risk and Disease Severity Matthieu Moisse,Ramona Zwamborn,Joke Vugt,Rick Spek,Wouter Rheenenet al. Annals of Neurology, 2021, 89 (4), pp.686-697. ⟨10.1002/ana.26009⟩ Article dans une revue hal-03350820v1
Targeting synaptic dysfunction using SINEUP ncRNA enhancer in neurodegenerative diseases Kathia Zaleta-Rivera,Stefano Espinoza,Roberto F. Delgadillo,Emmanuel Astoul,Sylviane Marouillatet al. LE STUDIUM Multidisciplinary Journal, 2021, 5, pp.62-69. ⟨10.34846/le-studium.214.02.fr.10-2021⟩ Article dans une revue hal-04198506v1
ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization Gijs H P Tazelaar,Steven Boeynaems,Mathias De Decker,Joke J F a Van Vugt,Lindy Koolet al. Brain Communications, 2020, 2 (2), pp.fcaa064. ⟨10.1093/braincomms/fcaa064⟩ Article dans une revue hal-02991948v1
Pre-symptomatic diagnosis in ALS P. Corcia,S. Lumbroso,C. Cazeneuve,K. Mouzat,W. Camuet al. Revue Neurologique, 2020, 176 (3), pp.166-169. ⟨10.1016/j.neurol.2019.07.027⟩ Article dans une revue hal-03351418v1
Advances in disease-modifying pharmacotherapies for the treatment of amyotrophic lateral sclerosis Rudolf Hergesheimer,Débora Lanznaster,Patrick Vourc’h,Christian R Andres,Se Bakkoucheet al. Expert Opinion on Pharmacotherapy, 2020, 21 (9), pp.1103-1110. ⟨10.1080/14656566.2020.1746270⟩ Article dans une revue hal-02869854v1
The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism Hélène Blasco,C Bessy,L Plantier,A Lefevre,E Piveret al. Scientific Reports, 2020, 10 (1), pp.16824. ⟨10.1038/s41598-020-73966-5⟩ Article dans une revue inserm-03412059v1
LIMK2-1 is a Hominidae-Specific Isoform of LIMK2 Expressed in Central Nervous System and Associated with Intellectual Disability Julie Tastet,Hélène Cuberos,Béatrice Vallée,Annick Toutain,Martine Raynaudet al. Neuroscience, 2019, 399, pp.199-210. ⟨10.1016/j.neuroscience.2018.12.017⟩ Article dans une revue istex hal-02067472v1
The debated toxic role of aggregated TDP-43 in amyotrophic lateral sclerosis: a resolution in sight? Rudolf C Hergesheimer,Anna A Chami,Denis Reis de Assis,Patrick Vourc’h,Christian Andreset al. Brain - A Journal of Neurology , 2019, 142 (5), pp.1176-1194. ⟨10.1093/brain/awz078⟩ Article dans une revue hal-02612470v1
Recombinant Intrabodies as Molecular Tools and Potential Therapeutics for Amyotrophic Lateral Sclerosis Dênis Reis de Assis,Anna Chami,Rudolf Hergesheimer,Judith Halewa,Seyedeh Tayebeh Ahmad Pouret al. LE STUDIUM Multidisciplinary Journal, 2019, pp.1-7. ⟨10.34846/le-studium.173.02.fr.03-2019⟩ Article dans une revue hal-03218538v1
Metabo-lipidomics of Fibroblasts and Mitochondrial-Endoplasmic Reticulum Extracts from ALS Patients Shows Alterations in Purine, Pyrimidine, Energetic, and Phospholipid Metabolisms Charlotte Veyrat-Durebex,Céline Bris,Philippe Codron,Cinzia Bocca,Stephanie Chupinet al. Molecular Neurobiology, 2019 Article dans une revue hal-02032108v1
The Relevancy of Data Regarding the Metabolism of Iron to Our Understanding of Deregulated Mechanisms in ALS; Hypotheses and Pitfalls Camille Petillon,Rudolf Hergesheimer,Hervé Puy,Philippe Corcia,Patrick Vourc’het al. Frontiers in Neuroscience, 2019, 12, pp.1031. ⟨10.3389/fnins.2018.01031⟩ Article dans une revue hal-02351424v1
Ferritin and LDL-cholesterol as biomarkers of fat-free mass loss in ALS Pierre Jésus,Hélène Blasco,Franck Patin,Salah Eddine Bakkouche,Stéphane Beltranet al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2019, 20 (5-6), pp.441-444. ⟨10.1080/21678421.2019.1597126⟩ Article dans une revue hal-02363239v1
C-reactive protein: A promising biomarker in ALS? Philippe Corcia,Hélène Blasco,C Beltran,Christian R Andres,Patrick Vourc’het al. Revue Neurologique, 2018, 174 (3), pp.104-105. ⟨10.1016/j.neurol.2017.07.001⟩ Article dans une revue hal-02051961v1
LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b Béatrice Vallée,Hélène Cuberos,Michel Doudeau,Fabienne Godin,David Gossetet al. Biochemical Journal, 2018, 475 (23), pp.3745-3761 Article dans une revue hal-01966439v1
Primary fibroblasts derived from sporadic amyotrophic lateral sclerosis patients do not show ALS cytological lesions Philippe Codron,Julien Cassereau,Patrick Vourc'H,Charlotte Veyrat-Durebex,Hélène Blascoet al. Amyotrophic lateral sclerosis & frontotemporal degeneration, 2018, 19 (5-6), pp.446-456. ⟨10.1080/21678421.2018.1431787⟩ Article dans une revue hal-01964500v1
The combination of four analytical methods to explore skeletal muscle metabolomics: Better coverage of metabolic pathways or a marketing argument? C. Bruno,F. Patin,C. Bocca,Lydie Nadal-Desbarats,F. Bonnieret al. Journal of Pharmaceutical and Biomedical Analysis, 2018, 148, pp.273 - 279. ⟨10.1016/j.jpba.2017.10.013⟩ Article dans une revue hal-01655608v1
Changes in glomerular filtration rate and outcomes in patients with atrial fibrillation Laurent Fauchier,Arnaud Bisson,Nicolas Clementy,Patrick Vourc’h,Denis Angoulvantet al. American Heart Journal, 2018, 198, pp.39-45. ⟨10.1016/j.ahj.2017.12.017⟩ Article dans une revue hal-03655485v1
Identification of metabolic pathway disturbances using multimodal metabolomics in autistic disorders in a Middle Eastern population Sylvie Mavel,Tania Bitar,Patrick Emond,Lydie Nadal-Desbarats,Antoine Lefèvreet al. Journal of Pharmaceutical and Biomedical Analysis, 2018, 152, pp.57 - 65. ⟨10.1016/j.jpba.2018.01.007⟩ Article dans une revue hal-01826422v1
Search for RASA1 Variants in Capillary Malformations of the Legs in 113 Children: Results from the French National Paediatric Cohort CONAPE Annabel Maruani,Marine Durieux-Verde,Juliette Mazereeuw-Hautier,Olivia Boccara,Ludovic Martinet al. Acta Dermato-Venereologica, 2018, 98 (2), pp.251-255. ⟨10.2340/00015555-2835⟩ Article dans une revue hal-02621329v1
In ALS, a mutation could be worth two steps Philippe Corcia,Hélène Blasco,S. Beltran,Christian R Andres,Patrick Vourc’het al. Revue Neurologique, 2018, 174 (10), pp.669-670 Article dans une revue hal-02025282v1
Phenotypic and genotypic studies of ALS cases in ALS-SMA families Philippe Corcia,Patrick Vourc’h,Hélène Blasco,Philippe Couratier,Audrey Dangoumauet al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2018, 19 (5-6), pp.432-437 Article dans une revue hal-02029592v1
The Metabolic Disturbances of Motoneurons Exposed to Glutamate Sylvie Mavel,Blandine Madji Hounoum,Hélène Blasco,Emmanuelle Coque,Patrick Vourc’het al. Molecular Neurobiology, 2018, ⟨10.1007/s12035-018-0945-8⟩ Article dans une revue hal-01826389v1
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia Russell L Mclaughlin,Dick Schijven,Wouter van Rheenen,Kristel R van Eijk,Margaret O’brienet al. Nature Communications, 2017, 8 (1), pp.14774. ⟨10.1038/ncomms14774⟩ Article dans une revue hal-04423266v1
Wildtype motoneurons, ALS‐Linked SOD1 mutation and glutamate profoundly modify astrocyte metabolism and lactate shuttling Blandine Madji Hounoum,Sylvie Mavel,Emmanuelle Coque,Franck Patin,Patrick Vourc’het al. Glia, 2017, 65 (4), pp.592 - 605. ⟨10.1002/glia.23114⟩ Article dans une revue hal-04767249v1
Omics to Explore Amyotrophic Lateral Sclerosis Evolution: the Central Role of Arginine and Proline Metabolism Franck Patin,Philippe Corcia,Patrick Vourc’h,Lydie Nadal-Desbarats,Thomas Baraneket al. Molecular Neurobiology, 2017, 54 (7), pp.5361-5374. ⟨10.1007/s12035-016-0078-x⟩ Article dans une revue hal-03534393v1
Ductal adenocarcinoma of the prostate: Clinical and biological profiles Armelle Vinceneux,Franck Bruyere,Olivier Haillot,Thomas Charles,Alexandre de La Tailleet al. Prostate, 2017, 77 (12), pp.1242 - 1250. ⟨10.1002/pros.23383⟩ Article dans une revue hal-01893586v1
SOD1 mutation can mask C9orf72 abnormal expansion P. Corcia,Hélène Blasco,G. Besson,J.P. Camdessanché,V. Pautotet al. European Journal of Neurology, 2017, 24 (4), pp.e24 - e24. ⟨10.1111/ene.13257⟩ Article dans une revue hal-01774095v1
Lipidomics Reveals Cerebrospinal-Fluid Signatures of ALS Hélène Blasco,Charlotte Veyrat-Durebex,Cinzia Bocca,Franck Patin,Patrick Vourc'Het al. Scientific Reports, 2017, 7, pp.17652. ⟨10.1038/s41598-017-17389-9⟩ Article dans une revue hal-02104331v1
Panel of oxidative stress and inflammatory biomarkers in als: a pilot study Helene Blasco,Guillaume Garcon,Franck Patin,Charlotte Veyrat-Durebex,Judith Boyeret al. Canadian Journal of Neurological Sciences, 2016, The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 44 (1), pp.90-95. ⟨10.1017/cjn.2016.284⟩ Article dans une revue hal-03776862v1
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis Wouter van Rheenen,Aleksey Shatunov,Annelot Dekker,Russell Mclaughlin,Frank Diekstraet al. Nature Genetics, 2016, 48 (9), pp.1043-1048. ⟨10.1038/ng.3622⟩ Article dans une revue hal-03939751v1
NSC-34 Motor Neuron-Like Cells Are Unsuitable as Experimental Model for Glutamate-Mediated Excitotoxicity Blandine Madji Hounoum,Patrick Vourc’h,Romain Felix,Philippe Corcia,Franck Patinet al. Frontiers in Cellular Neuroscience, 2016, 10, pp.118. ⟨10.3389/fncel.2016.00118⟩ Article dans une revue hal-04767258v1
Mutation screening of the ubiquitin ligase gene RNF135 in French patients with autism Julie Tastet,Loïc Decalonne,Sylviane Marouillat,Joëlle Malvy,Rose-Anne Thépaultet al. Psychiatric Genetics, 2015, 25 (6), pp.263-267. ⟨10.1097/ypg.0000000000000100⟩ Article dans une revue hal-02072312v1
A common functional allele of the Nogo receptor gene, reticulon 4 receptor (RTN4R), is associated with sporadic amyotrophic lateral sclerosis in a French population Maïté Amy,Oliver Staehlin,Frédérique René,Hélène Blasco,Sylviane Marouillatet al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2015, 16 (7-8), pp.490--496 Article dans une revue hal-01985793v1
Deficits in Information Transfer between Hospital-Based and Primary-Care Physicians, the Case of Kidney Disease: A Cross-Sectional Study Benedicte Sautenet,Agnès Caille,Bruno Giraudeau,Julie Léger,Patrick Vourc’het al. Journal of Nephrology, 2015, 28 (5), pp.563-570. ⟨10.1007/s40620-015-0175-3⟩ Article dans une revue hal-03156122v1
Roles of LIM kinases in central nervous system function and dysfunction H. Cuberos,B. Vallée,Patrick Vourc’h,J. Tastet,Christian R Andreset al. FEBS Letters, 2015, 589 (24PartB), pp.3795-3806. ⟨10.1016/j.febslet.2015.10.032⟩ Article dans une revue hal-02072231v1
Serum influence on in-vitro gene delivery using microbubble-assisted ultrasound Aya Zeghimi,Novell Anthony,Rose-Anne Thepault,Patrick Vourc'H,Ayache Bouakazet al. Journal of Drug Targeting, 2014, 22 (8), pp.748-760. ⟨10.3109/1061186X.2014.921922⟩ Article dans une revue inserm-02438479v1
A Prospective Study of Estimated Glomerular Filtration Rate and Outcomes in Patients With Atrial Fibrillation Amitava Banerjee,Laurent Fauchier,Patrick Vourc'H,Christian Andres,Sophie Taillandieret al. Chest, 2014, 145 (6), pp.1370-1382. ⟨10.1378/chest.13-2103⟩ Article dans une revue hal-03677545v1
Renal Impairment and Ischemic Stroke Risk Assessment in Patients With Atrial Fibrillation Amitava Banerjee,Laurent Fauchier,Patrick Vourc’h,Christian R Andres,Sophie Taillandieret al. Journal of the American College of Cardiology, 2013, 61 (20), pp.2079-2087. ⟨10.1016/j.jacc.2013.02.035⟩ Article dans une revue hal-03679433v1
Xq27 FRAXA Locus is a Strong Candidate for Dyslexia: Evidence from a Genome-Wide Scan in French Families M. Huc-Chabrolle,Céline Charon,A. Guilmatre,Patrick Vourc’h,G. Tripiet al. Behavior Genetics, 2013, 43 (2), pp.132-140. ⟨10.1007/s10519-012-9575-5⟩ Article dans une revue cea-04608759v1
Total protein level in cerebrospinal fluid is stable in elderly adults Diane Dufour-Rainfray,Emilie Beaufils,Patrick Vourc’h,Emilie Vierron,Laurent Mereghettiet al. Journal of the American Geriatrics Society, 2013, 61 (10), pp.1819-1821. ⟨10.1111/jgs.12489⟩ Article dans une revue istex hal-02650316v1
1H-13C NMR-based urine metabolic profiling in autism spectrum disorders. Sylvie Mavel,Lydie Nadal-Desbarats,Hélène Blasco,Frédérique Bonnet-Brilhault,Catherine Barthélémyet al. Talanta, 2013, 114, pp.95-102. ⟨10.1016/j.talanta.2013.03.064⟩ Article dans une revue inserm-00908985v1
GC-MS-based urine metabolic profiling of autism spectrum disorders. Patrick Emond,Sylvie Mavel,Nacima Aïdoud,Lydie Nadal-Desbarats,Frédéric Montignyet al. Analytical and Bioanalytical Chemistry, 2013, 405 (15), pp.5291-300. ⟨10.1007/s00216-013-6934-x⟩ Article dans une revue inserm-00908948v1
Idiopathic Parkinson's disease phenotype related to C9ORF72 repeat expansions: contribution of the neuropsychological assessment. Mariam Annan,Émilie Beaufils,Ursule-Catherine Viola,Patrick Vourc’h,Caroline Hommetet al. BMC Research Notes, 2013, 6 (1), pp.343. ⟨10.1186/1756-0500-6-343⟩ Article dans une revue inserm-00871180v1
mRNA-selective translation induced by FSH in primary Sertoli cells Astrid Musnier,K. Leon,J. Morales,Eric Reiter,Thomas Bouloet al. Molecular Endocrinology -Baltimore-, 2012, 26 (4), pp.669-680. ⟨10.1210/me.2011-1267⟩ Article dans une revue hal-01129597v1
LIMK2d, a truncated isoform of Lim kinase 2 regulates neurite growth in absence of the LIM kinase domain Julie Tastet,Patrick Vourc’h,Frédéric Laumonnier,Béatrice Vallée,Carole Michelleet al. Biochemical and Biophysical Research Communications, 2012, 420 (2), pp.247-252. ⟨10.1016/j.bbrc.2012.02.134⟩ Article dans une revue istex hal-01136281v1
Study of the HFE gene common polymorphisms in French patients with sporadic amyotrophic lateral sclerosis. Julien Praline,Hélène Blasco,Patrick Vourc’h,Valérian Rat,Chantal Gendrotet al. Journal of the Neurological Sciences, 2012, 317 (1-2), pp.58-61. ⟨10.1016/j.jns.2012.02.029⟩ Article dans une revue istex hal-00927560v1
The P413L chromogranin B variation in French patients with sporadic amyotrophic lateral sclerosis. Hélène Blasco,Philippe Corcia,Charlotte Veyrat-Durebex,Cathleen Coutadeur,Clémentine Fournieret al. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 2011, 12 (3), pp.210-4. ⟨10.3109/17482968.2010.522587⟩ Article dans une revue hal-00926892v1
Association between divalent metal transport 1 encoding gene (SLC11A2) and disease duration in amyotrophic lateral sclerosis. Hélène Blasco,Patrick Vourc’h,Yann Nadjar,Bénédicte Ribourtout,Paul H Gordonet al. Journal of the Neurological Sciences, 2011, 303 (1-2), pp.124-7. ⟨10.1016/j.jns.2010.12.018⟩ Article dans une revue istex hal-00926903v1
Study of the serotonin transporter (SLC6A4) and BDNF genes in French patients with non syndromic mental deficiency. Refaat Tabagh,Christian R Andres,Sylviane Védrine,Catherine Cherpi-Antar,Rose-Anne Thepaultet al. BMC Medical Genetics, 2010, 11 (1), pp.30. ⟨10.1186/1471-2350-11-30⟩ Article dans une revue inserm-00663530v1
Respiratory onset in an ALS family with L144F SOD1mutation Philippe Corcia,Philippe Petiot,Zorica Stevic,Patrick Vourc’h,Raoul Moraleset al. Journal of Neurology, Neurosurgery and Psychiatry, 2010, 82 (7), pp.747. ⟨10.1136/jnnp.2009.197558⟩ Article dans une revue istex hal-00600748v1
Association study of the ubiquitin conjugating enzyme gene UBE2H in sporadic ALS. Isabelle Martin,Patrick Vourc’h,Marie Mahé,Rose-Anne Thépault,Catherine Antaret al. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 2009, 10 (5-6), pp.432-5. ⟨10.3109/17482960802444972⟩ Article dans une revue hal-00926733v1
Effect of the oligodendrocyte myelin glycoprotein (OMgp) on the expansion and neuronal differentiation of rat neural stem cells Isabelle Martin,Christian Andres,Sylviane Védrine,Refaat Tabagh,Caroline Michelleet al. Brain Research, 2009, 1284, pp.22-30. ⟨10.1016/j.brainres.2009.05.070⟩ Article dans une revue istex hal-02527025v1
Mutations of the ANG gene in French patients with sporadic amyotrophic lateral sclerosis. Agathe Paubel,Jeremy Violette,Maïté Amy,Julien Praline,Vincent Meiningeret al. Archives of Neurology -Chigago-, 2008, 65 (10), pp.1333-6. ⟨10.1001/archneur.65.10.1333⟩ Article dans une revue hal-00926684v1
Exclusion of the coding sequence of the doublecortin gene as a susceptibility locus in autistic disorder Patrick Vourc'H,Elisabeth Petit-Teixeira,Jean Pierre Müh,Christian Andres,Thierry Bienvenuet al. American Journal of Medical Genetics, 2002, 108 (2), pp.164-167. ⟨10.1002/ajmg.10210⟩ Article dans une revue istex hal-02019548v1
No mutations in the coding region of the Rett syndrome gene MECP2 in 59 autistic patients Patrick Vourc'H,Thierry Bienvenu,Cherif Beldjord,Jamel Chelly,Catherine Barthélémyet al. European Journal of Human Genetics, 2001, 9 (7), pp.556-558. ⟨10.1038/sj.ejhg.5200660⟩ Article dans une revue hal-04110913v1

Poster de conférence (7)

LIM kinases are promising therapeutic targets: from the development of small molecule inhibitors targeting these kinases to preclinical validation on different mouse models. Béatrice Vallée,Rayan Berabez,Anthony Champiré,Régis Brion,Abdennour Brakaet al. 47th FEBS Congress, Jul 2023, Tours (FR), France Poster de conférence hal-04906944v1
Molecular and functional characterization of LIMK2-1, a hominidae-specific isoform of LIMK2 associated with intellectual disability H. Bénédetti,Béatrice Vallée,J. Tastet,H. Cubéros,A. Toutainet al. NeuroFrance 2019, May 2019, Marseille, France Poster de conférence hal-02924881v1
LIM kinases as new therapeutic targets for the treatment of neurofibromatosis type 1 A. Champiré,A. Braka,B. Vallée,M. Doudeau,F. Godinet al. VII International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC) –, Aug 2017, Vienne, Austria Poster de conférence hal-02904794v1
LIM kinases: new therapeutic targets to treat Neurofibromatosis type I Béatrice Vallée,Michel Doudeau,Fabienne Godin,Anthony Champiré,Karen Pléet al. The 7th EMBO meeting, Sep 2016, Mannheim, Germany. Poster de conférence hal-02453490v1
The three isoforms of human LIMK2 regulate actin cytoskeleton remodeling via different pathways Béatrice Vallée,Hélène Cuberos,Michel Doudeau,Fabienne Godin,Patrick Vourc’het al. EMBL Symposium, Actin in action: From Molecules to Cellular Functions, Sep 2016, Heidelberg, Germany. Poster de conférence hal-02453489v1
LIMK2-1, a new primate-specific isoform of LIMK2, is associated with intellectual disability Béatrice Vallée,Hélène Cuberos,Julie Tastet,Michel Doudeau,Fabienne Godinet al. 10 th FENS (Forum of Neurosciences), Jul 2016, Copenhague, Denmark. Poster de conférence hal-02453486v1
LIMK2 (LIM kinase2) isoforms are differentially expressed during neuronal differentiation J. Tastet,P. Vourc'H,F. Laumonnier,C. Michelle,Anne Duittozet al. 7. FENS Forum of European Neuroscience, Jul 2010, Amsterdam, Netherlands. n.p., 2010 Poster de conférence hal-02818145v1

Brevet (1)

4-(7H-Pyrrolo[2,3-D]pyrimidin-4-yl)-3,6-dihydropyridine-(2H)-carboxamide derivatives as Limk and/or Rock kinases inhibitors for use in the treatment of cancer Sylvain Routier,Hélène Bénédetti,Béatrice Vallée,Pascal Bonnet,Karen Pléet al. France, Patent n° : WO2021239727 A1. AMV. 2021 Brevet hal-03555349v1

Communication dans un congrès (6)

Corrélations entre les paramètres biologiques et la composition corporelle dans la sclérose latérale amyotrophique Pierre Jésus,F Patin,S.E. Bakkouche,S. Beltran,C.R. Andreset al. Journées Francophones de Nutrition (JFN), Société Française de Nutrition (SFN) et la Société Francophone de Nutrition Clinique et Métabolisme (SFNEP), Nov 2018, Nice, France. pp.64 Communication dans un congrès hal-02365870v1
Dynamic hormonal control of mRNA translation Kelly León,Astrid Musnier,Thomas Boulo,Gwenhael Jegot,Sophie Tesseraudet al. GDR 3545: RCPG-Physio-Med, Centre National de la Recherche Scientifique (CNRS). Paris, FRA., Oct 2013, Paris, France. 1 p Communication dans un congrès hal-02810531v1
Dynamique du contrôle hormonal de la traduction des ARNm Kelly León,Astrid Musnier,Thomas Boulo,Sophie Tesseraud,Vlad Costacheet al. 25. Colloque Biotechnocentre, Association pour le Développement des Biotechnologies en Région Centre (Biotechnocentre). Tours, FRA., Oct 2012, Seillac, France Communication dans un congrès hal-02748238v1
Effect of the oligodendrocyte myelin glycoprotein (OMgp) on the expansion and neuronal differentiation of rat neural stem cells I. Martin,Charles Andres,S. Védrine,Tabagh Refaat,Michelle Carolineet al. 9. Colloque de la Société des Neurosciences, May 2009, Bordeaux, France. n.p., ⟨10.1016/j.brainres.2009.05.070⟩ Communication dans un congrès istex hal-02819790v1
Expression des isoformes de LIM Kinase 2 pendant la neurogenèse et la stimulation des neurones J. Tastet,P. Vourc'H,F. Laumonnier,C. Michelle,Anne Duittozet al. 22. Colloque Biotechnocentre, Oct 2009, Seillac, France Communication dans un congrès hal-02753426v1
Inhibition of neural precursor cell proliferation by the oligodendrocyte myelin glycoprotein (OMgp) P. Vourc'H,I. Martin,S. Védrine,M. Amy,P. Corciaet al. 8. Colloque de la Société des Neurosciences, May 2007, Montpellier, France. n.p Communication dans un congrès hal-02819833v1