Patrizia Giannoni Patrizia GiannoniMCF Biologie HC, HDR, Codirectrice UPR CHROME, Chargée de mission &quot;Aide à la réussite&quot;

Identifiants chercheurs

IdHAL :

patrizia-giannoni

Présentation

EDUCATION

**2022 **HDR délivré par l'Université de Nîmes, France

**2008 Doctorat ès Pharmacologie et Toxicologie délivré par l'Université de Florence, Italie

**2004 Doctorat ès Pharmacie cum laude délivré par l'Université de Florence, Italie

PARCOURS PROFESSIONNEL

**2018- present Maître de conférences; Université de Nimes, Equipe Chrome (EA7352), Nimes, France

**2016- 2018 ATER en biologie; Université de Nimes, Equipe Chrome (EA7352), Nimes, France

**2011-2016 Stage post-doctoral; Institut de Génomique Fonctionnelle (IGF), Montpellier, France

2008-2011Stage post-doctoral; New York University Medical center, New York, NY, USA

activités d’edition**Editeur pour **: Frontiers in Aging Neuroscience (IF=4.5)

https://www.frontiersin.org/research-topics/8864/identification-of-multiple-targets-in-the-fight-against-alzheimers-disease

https://www.frontiersin.org/research-topics/19199/environmental-clues-to-brain-disease

Editeur invité pour: · Journal of Clinical Medicine (4.241) https://www.mdpi.com/journal/jcm/special_issues/alzheimer_disease_blueprints_and_therapeutic_hints).

-Experte scientifique (reviewer) pour:

Molecules, Brain Sciences, Toxines, Journal of Clinical Medicine, Neuroscience, Journal of Neuroscience Research, International Journal of Molecular Sciences, Biomolecules, Psychopharmacology, Nutrients, Medicina, Pharmaceutics, Microorganisms, International Journal of Environmental Research and Public Health, Ecotoxicology and Environmental Safety

https://publons.com/researcher/1234310/patrizia-giannoni/

Publications

Article dans une revue (25)

The same but different: impact of animal facility sanitary status on a transgenic mouse model of Alzheimer’s disease Caroline Ismeurt-Walmsley,Patrizia Giannoni,Florence Servant,Linda-Nora Mekki,Kevin Barangeret al. mBio, In press, 16 (5), pp.e0400124. ⟨10.1128/mbio.04001-24⟩ Article dans une revue hal-05049573v1
Effects of environmental concentrations of toxins BMAA and its isomers DAB and AEG on zebrafish larvae Jeanne Lichtfouse,Audrey Courtier,Annette C Vergunst,Patrizia Giannoni Ecotoxicology and Environmental Safety, 2024, 285, ⟨10.1016/j.ecoenv.2024.117045⟩ Article dans une revue hal-04706427v1
Brine shrimp Artemia salina to evaluate the impact of environmental concentrations of BMAA and isomers, DAB and AEG, via mortality (nauplii) and behavioural (adult) tests Jeanne Lichtfouse,L. Lécluse,A. Demelier,P. Giannoni Science of the Total Environment, 2024, 957, pp.177521. ⟨10.1016/j.scitotenv.2024.177521⟩ Article dans une revue hal-04868626v1
Editorial: Environmental clues to brain disease Patrizia Giannoni,Federica Bertaso,Gustavo Provensi Frontiers in Aging Neuroscience, 2023, 15, pp.1220484. ⟨10.3389/fnagi.2023.1220484⟩ Article dans une revue hal-04136217v1
Environmental bacteria as triggers to brain disease: Possible mechanisms of toxicity and associated human risk Audrey Courtier,Damien Potheret,Patrizia Giannoni Life Sciences, 2022, 304, pp.120689. ⟨10.1016/j.lfs.2022.120689⟩ Article dans une revue hal-04064228v1
Donecopride, a Swiss army knife with potential interest against Alzheimer's disease Christophe Rochais,Cédric Lecoutey,Katia Hamidouche,Patrizia Giannoni,Florence Gavenet al. British Journal of Pharmacology, In press, 177 (9), pp.1988-2005. ⟨10.1111/bph.14964⟩ Article dans une revue hal-02428730v1
Editorial: Identification of Multiple Targets in the Fight Against Alzheimer's Disease Patrizia Giannoni,Silvia Fossati,Elena Marcello,Sylvie Claeysen Frontiers in Aging Neuroscience, 2020, 12, pp.169. ⟨10.3389/fnagi.2020.00169⟩ Article dans une revue hal-02871844v1
Peripheral Routes to Neurodegeneration: Passing Through the Blood–Brain Barrier Patrizia Giannoni,Sylvie Claeysen,Francesco Noe,Nicola Marchi Frontiers in Aging Neuroscience, 2020, 12, pp.3. ⟨10.3389/fnagi.2020.00003⟩ Article dans une revue hal-02465771v1
Development of a DGGE method to explore Legionella communities Sandrine Bayle,B Martinez-Arribas,S. Jarraud,Patrizia Giannoni,L Garrellyet al. Heliyon, 2020, 6 (1), pp.e03149. ⟨10.1016/j.heliyon.2019.e03149⟩ Article dans une revue hal-02430628v1
The pericyte–glia interface at the blood–brain barrier Patrizia Giannoni,Jerome Badaut,Cyril Dargazanli,Alexis Fayd'Herbe de Maudave,Wendy Klementet al. Clinical Science, 2018, 132 (3), pp.361-374. ⟨10.1042/CS20171634⟩ Article dans une revue hal-02074159v1
Chronic treatments with a 5-HT4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer's disease Kévin Baranger,Patrizia Giannoni,Stéphane Girard,Sarah Girot,Florence Gavenet al. Neuropharmacology, 2017, 126, pp.128-141. ⟨10.1016/j.neuropharm.2017.08.031⟩ Article dans une revue hal-01799428v1
Longitudinal in vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases Margarita Arango-Lievano,Patrizia Giannoni,Sylvie Claeysen,Nicola Marchi,Freddy Jeanneteau Journal of visualized experiments : JoVE, 2016, ⟨10.3791/54796⟩ Article dans une revue hal-02368047v1
Cerebrovascular pathology during the progression of experimental Alzheimer's disease Patrizia Giannoni,Margarita Arango-Lievano,Ines das Neves,Marie-Claude Rousset,Kévin Barangeret al. Neurobiology of Disease, 2016, 88, pp.107-117. ⟨10.1016/j.nbd.2016.01.001⟩ Article dans une revue hal-01477817v1
In vivo Differential Brain Clearance and Catabolism of Monomeric and Oligomeric Alzheimer's Aβ protein Farron Mcintee,Patrizia Giannoni,Steven Blais,George Sommer,Thomas Neubertet al. Frontiers in Aging Neuroscience, 2016, 8, ⟨10.3389/fnagi.2016.00223⟩ Article dans une revue hal-01705732v1
The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain Silvia Fossati,Patrizia Giannoni,Maria E Solesio,Sarah L Cocklin,Erwin Cabreraet al. Neurobiology of Disease, 2016, 86, pp.29-40. ⟨10.1016/j.nbd.2015.11.006⟩ Article dans une revue hal-01997866v1
Serotonin: a new hope in Alzheimer's disease? Sylvie Claeysen,Joël Bockaert,Patrizia Giannoni ACS Chemical Neuroscience, 2015, 6 (7), pp.940-943. ⟨10.1021/acschemneuro.5b00135⟩ Article dans une revue hal-01792388v1
Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT 4 R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride Cédric Lecoutey,Cédric Lecoutey,Florence Gaven,Patrizia Giannoni,Katia Hamidoucheet al. Journal of Medicinal Chemistry, 2015, 58 (7), pp.3172-3187. ⟨10.1021/acs.jmedchem.5b00115⟩ Article dans une revue hal-02043873v1
Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment Cédric Lecoutey,Damien Hedou,Thomas Freret,Patrizia Giannoni,Florence Gavenet al. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (36), pp.E3825--30. ⟨10.1073/pnas.1410315111⟩ Article dans une revue hal-01800439v2
Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer’s disease Patrizia Giannoni,Florence Gaven,Dimitri de Bundel,Kévin Baranger,Evelyne Marchetti-Gauthieret al. Frontiers in Aging Neuroscience, 2013, 5, pp.96. ⟨10.3389/fnagi.2013.00096⟩ Article dans une revue hal-01703910v1
Alzheimer culprits: cellular crossroads and interplay Sylvie Claeysen,Maud Cochet-Bissuel,Romain Donneger,Aline Dumuis,Joël Bockaertet al. Cellular Signalling, 2012, 24 (9), pp.1831-1840. ⟨10.1016/j.cellsig.2012.05.008⟩ Article dans une revue hal-01792371v1
HISTAMINE NEURONAL SYSTEM AS THERAPEUTIC TARGET FOR THE TREATMENT OF COGNITIVE DISORDERS Patrizio Blandina,Leonardo Munari,Patrizia Giannoni,Chiara Mariottini,Maria Beatrice Passani Future Neurology, 2010, ⟨10.2217/fnl.10.30⟩ Article dans une revue hal-01793879v1
Heterogeneity of histaminergic neurons in the tuberomammillary nucleus of the rat Patrizia Giannoni,Maria-Beatrice Passani,Daniele Nosi,Paul L Chazot,Fiona C Shentonet al. European Journal of Neuroscience, 2009 Article dans une revue hal-01756945v1
Regional Differential Effects of the Novel Histamine H3 Receptor Antagonist 6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254) on Histamine Release in the Central Nervous System of Freely Moving Rats Patrizia Giannoni,Andrew Medhurst,M. Passani,M. Giovannini,C. Balliniet al. Journal of Pharmacology and Experimental Therapeutics, 2009, 332 (1), pp.164 - 172. ⟨10.1124/jpet.109.158444⟩ Article dans une revue hal-01764810v1
Histamine in the brain: Beyond sleep and memory Maria Beatrice Passani,Corrado Bucherelli,Elisabetta Baldi,Patrizio Blandina,Patrizia Giannoni Biochemical Pharmacology, 2007, 73 (8), pp.1113 - 1122. ⟨10.1016/j.bcp.2006.12.002⟩ Article dans une revue hal-01762502v1
Differential effect of cannabinoid agonists and endocannabinoids on histamine release from distinct regions of the rat brain Gabriele Cenni,Patrizio Blandina,Ken Mackie,Daniele Nosi,Lucia Formigliet al. European Journal of Neuroscience, 2006, 24 (6), pp.1633 - 1644. ⟨10.1111/j.1460-9568.2006.05046.x⟩ Article dans une revue hal-01764807v1

Chapitre d'ouvrage (4)

Histamine Receptors_Chapter6_The Evolving Landscape of Histaminergic Neurons’ Heterogeneity: Functional and Therapeutic Implications Patrizia Giannoni Histamine receptors, Springer Nature Switzerland, 2025, The Receptors, 978-3-031-98920-9. ⟨10.1007/978-3-031-98921-6⟩ Chapitre d'ouvrage hal-05292373v1
The 5×FAD mouse model of Alzheimer's disease Sylvie Claeysen,Patrizia Giannoni,Caroline Ismeurt The Neuroscience of Dementia, 1 (Chapter 13), Academic Press, pp.207-221, 2020, Diagnosis and Management in Dementia, 9780128158548. ⟨10.1016/B978-0-12-815854-8.00013-6⟩ Chapitre d'ouvrage hal-02920524v1
Heterogeneity of Histaminergic Neurons Patrizia Giannoni Patrizio Blandina; Maria Beatrice Passani. Histamine Receptors, Histamine Receptors (28), Humana Press, 2016, The Receptors, 978-3-319-40306-9. ⟨10.1007/978-3-319-40308-3_10⟩ Chapitre d'ouvrage hal-02147863v1
Serotonin type 4 receptor dimers Sylvie Claeysen,Romain Donneger,Patrizia Giannoni,Florence Gaven,Lucie P. Pellissier Methods in Cell Biology - Receptor-Receptor Interactions, 117, Academic Press - Elsevier, pp.123-139, 2013, 117, 978-0-12-408143-7. ⟨10.1016/B978-0-12-408143-7.00007-4⟩ Chapitre d'ouvrage hal-01792387v1

Communication dans un congrès (14)

Zebrafish larvae exposed to BMAA and isomers DAB and AEG: a morphological and behavioural study Jeanne Lichtfouse,Audrey Courtier,Annette C Vergunst,Patrizia Giannoni SETAC EUROPE 34TH ANNUAL MEETING, Society of Environmental Toxicology and Chemistry, May 2024, Séville, Spain Communication dans un congrès hal-04594098v1
PRESCRIPTION DE BENZODIAZEPINES ET CONTAMINATION ENVIRONNEMENTALE -ANALYSE RETROSPECTIVE (2015-2022) Jeanne Lichtfouse,Antoine Bonnière,Patrizia Giannoni,Eric Lichtfouse SEFA-Société Française d’Ecotoxicologie Fondamentale et Appliquée, Jul 2024, Besançon, France Communication dans un congrès hal-04920837v1
Unir la pédagogie active et les REL : développement des compétences, réussites personnelle et professionnelle Patrizia Giannoni,Zohra Benfodda Diversité, Réussite[s] dans l’Enseignement Supérieur (2024), Nantes Université [Nantes Univ], Apr 2024, Nantes, France Communication dans un congrès hal-04560072v1
Artemia salina : les crevettes d'eau salée Occitane pour étudier la cyanotoxine BMAA et ses isomères, DAB et AEG. Jeanne Lichtfouse,Lucas Lecluse,Anaëlle Demelier,Patrizia Giannoni Enjeux et impacts de la pollution chimique et des déchets en Méditerranée, ECOBIM, May 2024, Banyuls - sur - Mer, France Communication dans un congrès hal-04594271v1
EFFETS DE LA BMAA A DES CONCENTRATIONS ENVIRONNEMENTALES, SEULE OU EN MELANGE AVEC SES ISOMERES SUR LES LARVES DE POISSONS ZEBRES Jeanne Lichtfouse,Audrey Courtier,Annette C Vergunst,Patrizia Giannoni Colloque 2023 de la Société Française d’Ecotoxicologie Fondamentale et Appliquée, SEFA, Jul 2023, Le Havre, France Communication dans un congrès hal-04157661v1
Environmental and Health Impact of Micropollutants in the Thau Lagoon Audrey Courtier,Axelle Cadiere,Sandrine Bayle,Patrizia Giannoni,Benoit Roig SCICON2 - SETAC North America 41st Annual Meeting, Nov 2020, Congrès virtuel, France Communication dans un congrès hal-03094142v1
Caractérisation immunohistologique de la pathologie amyloïde et des symptômes associés dans un modèle murin dela maladie d'Alzheimer. (Conférencière invitée) Patrizia Giannoni,Florence Gaven,Sylvie Claeysen AFH: association française d'histotechnologie, Jun 2015, Montpellier, France Communication dans un congrès hal-02918582v1
Activation chronique du récepteur de la sérotonine de type 4 : Effet préventif dans un model murin de la maladied’Alzheimer. (Conférencière invitée) Patrizia Giannoni,Florence Gaven,Kévin Baranger,Santiago Rivera,Philippe Marinet al. Réunion francophone sur la maladie d'Alzheimer, Jun 2014, Montpellier, France Communication dans un congrès hal-02918585v1
Memory deficits of 5xFAD mice in the olfactory H maze test correlate with plaques development and are prevented by 5-HT4R agonist treatments. Patrizia Giannoni,Kévin Baranger,Sarah Girot,Stéphane Girard,Florence Gavenet al. AAIC, Jul 2014, Copenhague, Denmark Communication dans un congrès hal-02918560v1
New insights in molecular aspects of Alzheimer’s disease. Conférencière invitée. Patrizia Giannoni,Florence Gaven,Kévin Baranger,Santiago Rivera,Philippe Marinet al. Sindem, Mar 2013, Perugia, Italy Communication dans un congrès hal-02918588v1
5-HT4 agonists: novel promising agents for AD prevention. (Conférencière invitée) Patrizia Giannoni,Florence Gaven,Kévin Baranger,Santiago Rivera,Philippe Marinet al. 36 th meeting of Societa’ Italiana di Farmacologia, 2013, Turin (Italie), October 23, Oct 2013, Turin, Italy Communication dans un congrès hal-02918587v1
Prodromal stimulation of 5-HT4 receptors reduces amyloid pathology in 5XFAD mice. Patrizia Giannoni,Florence Gaven,Kévin Baranger,Santiago Rivera,Philippe Marinet al. Club de neuroprotection, Nov 2012, Paris, France Communication dans un congrès hal-02918562v1
Detection of functional heterogeneity of histaminergic neurons in response to GSK189254, a novel H3 antagonist. Patrizia Giannoni,Maria Beatrice Passani,Daniele Nosi,Andrew Medhurst,Paul L Chazotet al. 36 th meeting of the European Histamine Research Society, May 2007, Florence, Italy Communication dans un congrès hal-02918563v1
Different response to GABAa or H3 antagonists suggest the existence of distinct subpopulations among histaminergic neurons. Patrizia Giannoni,Gabriele Cenni,Maria Beatrice Passani,Pier Francesco Mannaioni,Andrew Medhurstet al. 35 th meeting of the European Histamine Research Society, May 2006, Delphes, Greece Communication dans un congrès hal-02918566v1

Poster de conférence (10)

MORPGHOLOGICAL AND BEHAVIOURAL ANALYSIS OF BMAA IN ZEBRAFISH LARVAE Jeanne Lichtfouse,Audrey Courtier,Annette C Vergunst,Patrizia Giannoni First French Zebrafish Meeting, Oct 2023, Montpellier, France Poster de conférence hal-04263376v1
BACTERIES ENVIRONNEMENTALES ET MALADIES DU CERVEAU Patrizia Giannoni,Audrey Courtier,Damien Potheret,Jeanne Lichtfouse Société d’Écotoxicologie Fondamentale et Appliquée (SEFA), Jul 2023, Le Havre, France Poster de conférence hal-04136234v1
Développement d'une méthode automatique de suivi de la croissance de Borrelia burgdorferi Damien Potheret,Patrizia Giannoni,Axelle Cadiere Microbes 2022 - 17e congrès national de la SFM, Oct 2022, Montpellier, France Poster de conférence hal-04108122v1
Microbiote intestinal et maladie d’Alzheimer : une piste stratégique pour des biomarqueurs innovants ? Patrizia Giannoni,Bérengère Coupé,Florence Gaven,Caroline Ismeurt,Kévin Barangeret al. Biomarker days, Jun 2017, Montpellier, France Poster de conférence hal-03131344v1
Impact du microbiote intestinal dans un modèle murin de maladie d’Alzheimer. Patrizia Giannoni,Bérengère Coupé,Florence Gaven,Kévin Baranger,Santiago Riveraet al. Réunion francophone sur la maladie d’Alzheimer et les syndromes apparentés, Jun 2016, Lyon, France Poster de conférence hal-02917762v1
Time dependent vascular pericyte changes in a genetic model of Alzheimer’s disease. Patrizia Giannoni,Margarita Arango-Lievano,Ines das Neves,Marie-Claude Rousset,Kévin Barangeret al. CBV: Conference on Cerebral Vascular Biology, Jul 2015, Paris, France Poster de conférence hal-02917765v1
Longitudinal cerebrovascular changes in a genetic model of Alzheimer’s disease. Patrizia Giannoni,Yacine Belkacemi,Marie-Claude Rousset,Baddreddine Boussadia,Florence Gavenet al. AD/PD, Mar 2015, Nice, France Poster de conférence hal-02918542v1
5 HT4 agonists: novel promising agents for AD prevention. Patrizia Giannoni,Florence Gaven,Kévin Baranger,Santiago Rivera,Philippe Marinet al. Congrès des Neurosciences Francaises, May 2013, Lyon, France Poster de conférence hal-02918543v1
5 HT4 agonists: novel promising agents for AD prevention. Patrizia Giannoni,Florence Gaven,Kévin Baranger,Santiago Rivera,Philippe Marinet al. AD/PD 2013, Mar 2013, Florence, Italy Poster de conférence hal-02918547v1
Functional heterogeneity of histaminergic neurons suggest interesting applications of GSK189254, a novel H3 receptor antagonist Patrizia Giannoni,Gabriele Cenni,Maria Beatrice Passani,Pier Francesco Mannaioni,Andrew Medhurstet al. 33 rd meeting of Societa’ Italiana di Farmacologia, Jun 2007, Cagliari, Italy Poster de conférence hal-02918555v1