Paul-Alain jaffrès Professeur, Université de Brest

Publications

Article dans une revue (161)

In vivo endosomal escape assay identifies mechanisms for efficient hepatic LNP delivery Antony Jozić,Chloé Le Roux,Jeonghwan Kim,Mathieu Berchel,Deepak Kumar Sahelet al. Nature Biotechnology, In press, ⟨10.1038/s41587-026-03022-6⟩ Article dans une revue hal-05548322v1
Maltodextrin-modified lipoplexes for enhanced mucosal penetration and efficient mRNA delivery Bojan Kopilovic,Nabila Laroui,Mathieu Berchel,Paul-Alain Jaffrès,Patrick Midouxet al. Materials Today Bio, 2025, 33, pp.101975. ⟨10.1016/j.mtbio.2025.101975⟩ Article dans une revue hal-05135837v1
Antifouling Properties of N,N′-Dialkylated Tetraazamacrocyclic Polyamines and Their Metal Complexes Mathieu Berchel,Dorsaf Malouch,Maryline Beyler,Maryline Fauchon,Yannick Toueixet al. Molecules, 2025, 30 (11), pp.2368. ⟨10.3390/molecules30112368⟩ Article dans une revue hal-05135902v1
Endogenous ether lipids differentially promote tumor aggressiveness by regulating the SK3 channel Marion Papin,Delphine Fontaine,Caroline Goupille,Sandy Figiel,Isabelle Domingoet al. Journal of Lipid Research, 2024, 65 (5), pp.100544. ⟨10.1016/j.jlr.2024.100544⟩ Article dans une revue hal-04752963v1
BSV163/DOPE‐mediated TRAIL gene transfection acts synergistically with chemotherapy against cisplatin‐resistant ovarian cancer Quoc Manh Nguyen,Pierre‐françois Dupré,Mathieu Berchel,Rosy Ghanem,Paul-Alain Jaffreset al. Chemical Biology and Drug Design, 2023, 103 (1), ⟨10.1111/cbdd.14357⟩ Article dans une revue hal-04505120v1
Evaluation of lipophosphoramidates-based amphiphilic compounds on the formation of biofilms of marine bacteria Dorsaf Malouch,Mathieu Berchel,Catherine Dreanno,Sabine Stachowski-Haberkorn,Morgane Chalopinet al. Biofouling, 2023, 39 (6), pp.591-605. ⟨10.1080/08927014.2023.2241377⟩ Article dans une revue hal-04309398v1
A new series of magnetic and luminescent layered hybrid materials obtained from thianthrene phosphonic acid: M(H 2 O)PO 3 -S 2 C 12 H 7 (M = Cu, Zn) and M(H 2 O) 2 (PO 2 OH-S 2 C 12 H 7 ) 2 (M = Mn, Co) Geoffrey Letheux,Parameshwari Ganesan,Fabien Veillon,Julien Varignon,Olivier Pérezet al. Dalton Transactions, 2023, 52, pp.18362-18379. ⟨10.1039/D3DT03153E⟩ Article dans une revue hal-04309258v1
Synthesis of ether lipids: natural compounds and analogues Marco Antônio G B Gomes,Alicia Bauduin,Chloé Le Roux,Romain Fouinneteau,Wilfried Bertheet al. Beilstein Journal of Organic Chemistry, 2023, 19, pp.1299-1369. ⟨10.3762/bjoc.19.96⟩ Article dans une revue (article de synthèse) hal-04553299v1
Gene transfection using branched cationic amphiphilic compounds for an aerosol administration in cystic fibrosis context Rosy Ghanem,Mathieu Berchel,Tanguy Haute,Xavier Buin,Véronique Laurentet al. International Journal of Pharmaceutics, 2023, 631, pp.122491. ⟨10.1016/j.ijpharm.2022.122491⟩ Article dans une revue hal-04169732v1
Aerosol-mediated non-viral lung gene therapy: The potential of aminoglycoside-based cationic liposomes Tony Le Gall,Mathieu Berchel,Lee Davies,Angélique Mottais,Rosy Ghanemet al. Pharmaceutics, 2022, 14 (1), pp.25. ⟨10.3390/pharmaceutics14010025⟩ Article dans une revue hal-03515151v1
mRNA Lipoplexes with Cationic and Ionizable α-Amino-lipophosphonates: Membrane Fusion, Transfection, mRNA Translation and Conformation Sohail Akhter,Mathieu Berchel,Paul-Alain Jaffrès,Chantal Pichon,Patrick Midoux Pharmaceutics, 2022, 14 (3), pp.581. ⟨10.3390/pharmaceutics14030581⟩ Article dans une revue hal-03927316v1
Phosphonodithioformate-amine coupling reaction: from basic discovery to application for the functionalization of liposomes Montassar Khalil,Dany Jeanne Dit Fouque,Mathieu Berchel,Aurore Fraix,Salvatore Sortinoet al. Phosphorus, Sulfur, and Silicon and the Related Elements, 2022, 197 (5-6), pp.462-467. ⟨10.1080/10426507.2021.2012177⟩ Article dans une revue hal-04553301v1
Liposome-Mediated Gene Transfer in Differentiated HepaRG™ Cells: Expression of Liver Specific Functions and Application to the Cytochrome P450 2D6 Expression Manuel Vlach,Hugo Coppens-Exandier,Agnès Jamin,Mathieu Berchel,Julien Scavineret al. Cells, 2022, 11 (23), pp.3904. ⟨10.3390/cells11233904⟩ Article dans une revue hal-03930086v1
Phosphonodithioester-amine coupling in water: a fast reaction to modify the surface of liposomes Montassar Khalil,Dany Jeanne Dit Fouque,Mathieu Berchel,Aurore Fraix,Aurélien Dupontet al. Organic & Biomolecular Chemistry, 2021, ⟨10.1039/d1ob01078f⟩ Article dans une revue hal-03282994v1
Synthetic alkyl-ether-lipid promotes TRPV2 channel trafficking trough PI3K/Akt-girdin axis in cancer cells and increases mammary tumour volume Maxime Guéguinou,Romain Felix,Séverine Marionneau-Lambot,Thibauld Oullier,Aubin Pennaet al. Cell Calcium, 2021, 97, pp.102435. ⟨10.1016/j.ceca.2021.102435⟩ Article dans une revue hal-03278876v1
Phosphonodithioester–Amine Coupling as a Key Reaction Step for the Design of Cationic Amphiphiles Used for Gene Delivery Montassar Khalil,Alexis Hocquigny,Mathieu Berchel,Tristan Montier,Paul-Alain Jaffrès Molecules, 2021, 26 (24), pp.7507. ⟨10.3390/molecules26247507⟩ Article dans une revue hal-05092141v1
Development of pyrene-based fluorescent ether lipid as inhibitor of SK3 ion channels Alicia Bauduin,Marion Papin,Aurélie Chantôme,Hélène Couthon,Laure Burel-Deschampset al. European Journal of Medicinal Chemistry, 2021, 209, pp.112894. ⟨10.1016/j.ejmech.2020.112894⟩ Article dans une revue hal-02997273v1
Thio-ether functionalized glycolipid amphiphilic compounds reveal a potent activator of SK3 channel with vasorelaxation effect Charlotte Sevrain,Delphine Fontaine,Alicia Bauduin,Maxime Guéguinou,Bei Li Zhanget al. Organic & Biomolecular Chemistry, 2021, 19 (12), pp.2753-2766. ⟨10.1039/D1OB00021G⟩ Article dans une revue hal-03187829v1
Branched lipid chains to prepare cationic amphiphiles producing hexagonal aggregates: supramolecular behavior and application to gene delivery Amal Bouraoui,Rosy Ghanem,Mathieu Berchel,Laure Burel-Deschamps,V. Viéet al. Organic & Biomolecular Chemistry, 2020, 18 (2), pp.337-345. ⟨10.1039/c9ob02381j⟩ Article dans une revue hal-02469674v1
M(H2O)(PO3C10H6OH)·(H2O)0.5 (M = Co, Mn, Zn, Cu): a new series of layered metallophosphonate compoundsobtained from 6-hydroxy-2-naphthylphosphonic acid Felicien Beaubras,Jean-Michel Rueff,Olivier Perez,Fabien Veillon,Vincent Caignaertet al. Dalton Transactions, 2020, 49 (12), pp.3877-3891. ⟨10.1039/C9DT03947C⟩ Article dans une revue hal-02413390v1
Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity Sana Kouba,Julien Braire,Romain Félix,Aurélie Chantôme,Paul-Alain Jaffreset al. European Journal of Medicinal Chemistry, 2020, 186, pp.111854. ⟨10.1016/j.ejmech.2019.111854⟩ Article dans une revue hal-03027843v1
Novel lipid‐based quaternary ammonium sophorolipid amphiphiles with antimicrobial and transfection activities Elisabeth I.P. Delbeke,Jonas Everaert,Olivier Lozach,Tony Le Gall,Mathieu Berchelet al. ChemSusChem, 2019, 12 (15), pp.3642-3653. ⟨10.1002/cssc.201900721⟩ Article dans une revue hal-02129348v1
Designing of a Magnetodielectric System in Hybrid Organic-inorganic framework, a Perovskite Layered Phosphonate MnO3PC6H4-m-Br.H2O Tathamay Basu,Clarisse Bloyet,Felicien Beaubras,Vincent Caignaert,Olivier Pérezet al. Advanced Functional Materials, 2019, 29 (33), pp.1901878. ⟨10.1002/adfm.201901878⟩ Article dans une revue hal-02159971v1
Bis-Thioether-Containing Lipid Chains in Cationic Amphiphiles: Physicochemical Properties and Applications in Gene Delivery Amal Bouraoui,Rosy Ghanem,Mathieu Berchel,Véronique Vié,Yann Le Guenet al. ChemPhysChem, 2019, 20 (17), pp.2187-2194. ⟨10.1002/cphc.201900626⟩ Article dans une revue hal-02278044v1
Substitution of unsaturated lipid chains by thioether-containing lipid chains in cationic amphiphiles: physicochemical consequences and application for gene delivery Amal Bouraoui,Mathieu Berchel,Rosy Ghanem,Véronique Vie,Gilles Paboeufet al. Organic & Biomolecular Chemistry, 2019, 17 (14), pp.3609-3616. ⟨10.1039/c9ob00473d⟩ Article dans une revue hal-02088106v1
Antibacterial and transfection activities of nebulized formulations incorporating long n-alkyl chain silver N-heterocyclic carbene complexes Angélique Mottais,Mathieu Berchel,Tony Le Gall,Yann Sibiril,Frédérique d'Arbonneauet al. International Journal of Pharmaceutics, 2019, 567, pp.118500. ⟨10.1016/j.ijpharm.2019.118500⟩ Article dans une revue hal-02302023v1
One-Dimensional Fluorene-Based Co(II) Phosphonate Co(H2O)2PO3C–C12H9·H2O: Structure and Magnetism Clarisse Bloyet,Jean-Michel Rueff,Olivier Perez,Alain Pautrat,Vincent Caignaertet al. Inorganics, 2018, 6 (3), pp.93. ⟨10.3390/inorganics6030093⟩ Article dans une revue hal-01870417v1
Preclinical evaluation of mRNA trimannosylated lipopolyplexes as therapeutic cancer vaccines targeting dendritic cells A. Le Moignic,V. Malard,T. Benvegnu,L. Lemiègre,Mathieu Berchelet al. Journal of Controlled Release, 2018, 278, pp.110 - 121. ⟨10.1016/j.jconrel.2018.03.035⟩ Article dans une revue istex hal-01774851v1
Synthesis of Alkyl-Glycerolipids Standards for Gas Chromatography Analysis: Application for Chimera and Shark Liver Oils Michelle Pinault,Cyrille Guimaraes,Hélène Couthon,Jérôme Thibonnet,Delphine Fontaineet al. Marine drugs, 2018, 16 (4), ⟨10.3390/md16040101⟩ Article dans une revue hal-01744078v1
Incipient spin–dipole coupling in a 1D helical-chain metal–organic hybrid Tathamay Basu,Clarisse Bloyet,Jean-Michel Rueff,Vincent Caignaert,Alain Pautratet al. Journal of Materials Chemistry C, 2018, 6 (38), pp.10207-10210. ⟨10.1039/C8TC04328K⟩ Article dans une revue hal-01887113v1
Excimer and Red Luminescence Due to Aggregation-Induced Emission in Naphthalene Based Zinc Phosphonate Clarisse Bloyet,Jean-Michel Rueff,Julien Cardin,Vincent Caignaert,Jean-Louis Doualanet al. European Journal of Inorganic Chemistry, 2018, 2018 (26), pp.3095-3103. ⟨10.1002/ejic.201800369⟩ Article dans une revue hal-01826146v1
Synthesis and biological evaluation of bolaamphiphilic sophorolipids Elisabeth Delbeke,Jonas Everaert,Olivier Lozach,Tony Le Gall,Mathieu Berchelet al. ACS Sustainable Chemistry & Engineering, 2018, 6 (7), pp.8992-9005. ⟨10.1021/acssuschemeng.8b01354⟩ Article dans une revue hal-01806695v1
Manganese Fluorene Phosphonates: Formation of Isolated Chains Clarisse Bloyet,Jean-Michel Rueff,Vincent Caignaert,Bernard Raveau,Jean-François Lohieret al. Inorganics, 2018, 6 (3), pp.92. ⟨10.3390/inorganics6030092⟩ Article dans une revue hal-01870421v1
Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety Kevin van Der Jeught,Stefaan de Koker,Lukasz Bialkowski,Carlo Heirman,Patrick Tjok Joeet al. ACS Nano, 2018, 12 (10), pp.9815-9829. ⟨10.1021/acsnano.8b00966⟩ Article dans une revue hal-01889829v1
Antibacterial Effect and DNA Delivery Using a Combination of an Arsonium-Containing Lipophosphoramide with an N -Heterocyclic Carbene-Silver Complex – Potential Benefits for Cystic Fibrosis Lung Gene Therapy Angélique Mottais,Mathieu Berchel,Yann Sibiril,Véronique Laurent,Deborah Gillet al. International Journal of Pharmaceutics, 2018, International Journal of Pharmaceutics, 536 (1), pp.29-41. ⟨10.1016/j.ijpharm.2017.11.022⟩ Article dans une revue istex hal-01638278v1
Synthesis of α-amino-lipophosphonates as cationic lipids or co-lipids for DNA transfection in dendritic cells Mathieu Berchel,Sohail Akhter,Wilfried Berthe,Cristine Gonçalvez,Marine Dubuissonet al. Journal of materials chemistry‎ B, 2017, J. Mater. Chem. B, 5, pp.6869-6881. ⟨10.1039/C7TB01080J⟩ Article dans une revue hal-01551638v1
Layered Simple Hydroxides Functionalized by Fluorene-Phosphonic Acids: Synthesis, Interface Theoretical Insights, and Magnetoelectric Effect Quentin Evrard,Ziyad Chaker,Mélissa Roger,Charlotte M. Sevrain,Emilie Delahayeet al. Advanced Functional Materials, 2017, 27 (41), pp.1703576. ⟨10.1002/adfm.201703576⟩ Article dans une revue hal-01624542v1
Phosphonic acid: preparation and applications Charlotte M Sevrain,Mathieu Berchel,Hélène Couthon,Paul-Alain Jaffrès Beilstein Journal of Organic Chemistry, 2017, 13, pp.2186 - 2213. ⟨10.3762/bjoc.13.219⟩ Article dans une revue hal-05092144v1
Fluorenyl Zinc Phosphonate Zn(H 2 O)PO 3 -C 13 H 9 ·H 2 O: Hybrid Columnar Structure with Strong C-H···π Interactions Clarisse Bloyet,Jean-Michel Rueff,Vincent Caignaert,Jean-François Lohier,Julien Cardinet al. Journal of Inorganic and General Chemistry / Zeitschrift für anorganische und allgemeine Chemie, 2017, 643 (3), pp.250-255. ⟨10.1002/zaac.201600362⟩ Article dans une revue hal-01425234v1
Phosphonic acid: preparation and applications Charlotte M. Sevrain,Mathieu Berchel,Hélène Couthon,Paul-Alain Jaffres Beilstein Journal of Organic Chemistry, 2017, 13, pp.2186 - 2213. ⟨10.3762/bjoc.13.219⟩ Article dans une revue hal-01624628v1
Singular Interaction between an Antimetastatic Agent and the Lipid Bilayer: The Ohmline Case Fernando Herrera,Charlotte M. Sevrain,Paul-Alain Jaffres,Hélène Couthon,Axelle Grélardet al. ACS Omega, 2017, 2 (10), pp.6361 - 6370. ⟨10.1021/acsomega.7b00936⟩ Article dans une revue hal-01624549v1
Important role of phosphoramido linkage in imidazole-based dioleyl helper lipids for liposome stability and primary cell transfection Mathieu Mével,Thomas Haudebourg,Thibault Colombani,Pauline Peuziat,Laurence Dalletet al. The Journal of Gene Medicine, 2016, 18 (1-3), pp.3 - 15. ⟨10.1002/jgm.2869⟩ Article dans une revue istex hal-01539660v1
Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes J. Barbeau,L. Lemiègre,A. Quelen,V. Malard,H. Gaoet al. Carbohydrate Research, 2016, 435, pp.142--148. ⟨10.1016/j.carres.2016.10.003⟩ Article dans une revue istex hal-01398046v1
Topochemical Route from Supramolecular to Hybrid Materials Tetraphenylmethane-Based Tectons and Lanthanum Phosphonate Derivative O. Perez,C. Bloyet,J.-M. Rueff,N. Barrier,V. Caignaertet al. Crystal Growth & Design, 2016, 16 (12), pp.6781-6789. ⟨10.1021/acs.cgd.6b00823⟩ Article dans une revue hal-02184726v1
New Disaccharide-Based Ether Lipids as SK3 Ion Channel Inhibitors Wilfried Berthe,Charlotte Sevrain,Aurélie Chantôme,Ana Maria Bouchet,Maxime Gueguinouet al. ChemMedChem, 2016, 11 (14), pp.1531 - 1539. ⟨10.1002/cmdc.201600147⟩ Article dans une revue istex hal-01474320v1
Evaluation of the transfection efficacies of quaternary ammonium salts prepared from sophorolipids E I P Delbeke,Olivier Lozach,T Le Gall,Mathieu Berchel,Tristan Montieret al. Organic & Biomolecular Chemistry, 2016, 11, pp.1650 - 3751. ⟨10.1039/C6OB00241B⟩ Article dans une revue hal-01519104v1
SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline Maxime Guéguinou,Thomas Harnois,David Crottes,Arnaud Uguen,Nadine Déliotet al. Oncotarget, 2016, 7, pp.36168-36184. ⟨10.18632/oncotarget.8786⟩ Article dans une revue hal-01539569v1
Copper–Fluorenephosphonate Cu­(PO3-C13H9)·H2O: A Layered Antiferromagnetic Hybrid Nathalie Hugot,Mélissa Roger,Jean-Michel Rueff,Julien Cardin,Olivier Perezet al. European Journal of Inorganic Chemistry, 2016, 2016 (2), pp.266-271. ⟨10.1002/ejic.201501041⟩ Article dans une revue hal-01239831v1
Alkyl ether lipids, ion channels and lipid raft reorganization in cancer therapy Paul-Alain Jaffres,Gajate Consuelo,Ana Bouchet,Hélène Couthon,Aurélie Chantômeet al. Pharmacology & Therapeutics, 2016, ⟨10.1016/j.pharmthera.2016.06.003⟩ Article dans une revue inserm-01330970v1
Triggering bilayer to inverted-hexagonal nanostructure formation by thiol–ene click chemistry on cationic lipids: consequences on gene transfection Damien Afonso,Tony Le Gall,Hélène Couthon,Axelle Grélard,Shipra Prakashet al. Soft Matter, 2016, 12 (20), pp.4516 - 4520. ⟨10.1039/c6sm00609d⟩ Article dans une revue hal-01517791v1
The Dimeric Pyramidal Cu 2 O 6 (H 2 O) 2 Unit - A Structural Invariant of a Homologous Series of Copper-Layered Phosphonates Clarisse Bloyet,Mélissa Roger,Jean-Michel Rueff,Bernard Raveau,Jean-François Lohieret al. European Journal of Inorganic Chemistry, 2016, 2016 (28), pp.4643 - 4648. ⟨10.1002/ejic.201600613⟩ Article dans une revue istex hal-01539324v1
Lipophosphoramidate-based bipolar amphiphiles: their syntheses and transfection properties Mathieu Berchel,Tony Le Gall,Olivier Lozach,Jean-Pierre Haelters,Tristan Montieret al. Organic & Biomolecular Chemistry, 2016, 14 (10), pp.2846 - 2853. ⟨10.1039/C5OB02512E⟩ Article dans une revue hal-01539654v1
Rigid phosphonic acid for the construction of crystalline organic-inorganic hybrid materials Mélissa Roger,Clarisse Bloyet,Quentin Evrard,Hélène Couthon,Mathieu Berchelet al. Phosphorus, Sulfur, and Silicon and the Related Elements, 2016, 191 (11-12), pp.1482 - 1484. ⟨10.1080/10426507.2016.1212048⟩ Article dans une revue hal-01539339v1
Glyco-phospho-glycero-ether lipid as modulator of SK3 ion channel and SK3-dependent cancer cell migration C. Sevrain,Wilfried Berthe,Hélène Couthon,J. P. Haelters,M. Bouchetet al. Phosphorus, Sulfur, and Silicon and the Related Elements, 2016, 191 (11-12), pp.1623 - 1624. ⟨10.1080/10426507.2016.1217221⟩ Article dans une revue hal-01539329v1
Synthetic phospholipids and phospho-bola-amphiphiles for nucleic acid delivery Mathieu Berchel,Olivier Lozach,Wilfried Berthe,Sylvie Hernot,Hélène Couthonet al. Phosphorus, Sulfur, and Silicon and the Related Elements, 2016, 191 (11-12), pp.1485 - 1487. ⟨10.1080/10426507.2016.1212049⟩ Article dans une revue hal-01539538v1
Hydrothermal synthesis for new multifunctional materials: A few examples of phosphates and phosphonate-based hybrid materials Jean-Michel Rueff,Maria Poienar,Anne Guesdon,Christine Martin,Antoine Maignanet al. Journal of Solid State Chemistry, 2016, 236, pp.236 - 245. ⟨10.1016/j.jssc.2015.09.018⟩ Article dans une revue istex hal-01539668v1
Evaluation of New Fluorescent Lipophosphoramidates for Gene Transfer and Biodistribution Studies after Systemic Administration Nawal Belmadi,Mathieu Berchel,Caroline Denis,Wilfried Berthe,Yann Sibirilet al. International Journal of Molecular Sciences, 2015, 16 (11), pp.26055 - 26076. ⟨10.3390/ijms161125941⟩ Article dans une revue hal-01538458v1
Cationic dialkylarylphosphates: a new family of bio-inspired cationic lipids for gene delivery Stéphanie S. Le Corre,Nawal Belmadi,Mathieu Berchel,Tony Le Gall,Pierre Haelterset al. Organic & Biomolecular Chemistry, 2015, 13 (4), pp.1122 - 1132. ⟨10.1039/C4OB01770F⟩ Article dans une revue hal-01535909v1
Synthetic vectors for gene delivery: An overview of their evolution depending on routes of administration Nawal Belmadi,Patrick Midoux,Pascal Loyer,Catherine Passirani,Chantal Pichonet al. Biotechnology Journal, 2015, 10 (9), pp.1370-1389. ⟨10.1002/biot.201400841⟩ Article dans une revue istex hal-01162373v1
Efficient in vivo transfection and safety profile of a CpG-free and codon optimized luciferase plasmid using a cationic lipophosphoramidate in a multiple intravenous administration procedure Mattias F. Lindberg,Tony Le Gall,Nathalie Carmoy,Mathieu Berchel,Stephen C. Hydeet al. Biomaterials, 2015, 59, pp.1 - 11. ⟨10.1016/j.biomaterials.2015.04.024⟩ Article dans une revue hal-01537615v1
Silver-Based Hybrid Materials from meta- or para-Phosphonobenzoic Acid: Influence of the Topology on Silver Release in Water Jean-Michel Rueff,Olivier Perez,Vincent Caignaert,Gary Hix,Mathieu Berchelet al. Inorganic Chemistry, 2015, 54, pp.2152 - 2159. ⟨10.1021/ic502395s⟩ Article dans une revue hal-05092137v1
Synthesis of lipid-based unsymmetrical O,O-dialkylphosphites Mathieu Berchel,Jimmy Haddad,Stéphanie Le Corre,Jean-Pierre Haelters,Paul-Alain Jaffres Tetrahedron Letters, 2015, 56 (18), pp.2345 - 2348. ⟨10.1016/j.tetlet.2015.03.093⟩ Article dans une revue istex hal-01540799v1
Enhanced Achilles tendon healing by fibromodulin gene transfer Anthony Delalande,Marie-Pierre Gosselin,Arnaud Suwalski,William Guilmain,Chloé Leducet al. Nanomedicine: Nanotechnology, Biology and Medicine, 2015, 11 (7), pp.1735 - 1744. ⟨10.1016/j.nano.2015.05.004⟩ Article dans une revue istex hal-01537597v1
La1−xLnxH(O3PCH3)2 (Ln = Tb, Eu; 0 &lt; x ≤ 1): an organic–inorganic hybrid with lanthanide chains and tunable luminescence properties B. Mutelet,S. Boudin,O. Pérez,J. M. Rueff,C. Labbeet al. Dalton Transactions, 2015, 44 (3), pp.1186. ⟨10.1039/C4DT02643H⟩ Article dans une revue hal-01241216v1
Silver-Based Hybrid Materials from meta- or para-Phosphonobenzoic Acid: Influence of the Topology on Silver Release in Water Jean-Michel Rueff,Olivier Perez,Vincent Caignaert,Gary Hix,Mathieu Berchelet al. Inorganic Chemistry, 2015, 54 (5), pp.2152 - 2159. ⟨10.1021/ic502395s⟩ Article dans une revue hal-01532232v1
Cationic Lipophosphoramidates Containing a Hydroxylated Polar Headgroup for Improving Gene Delivery Mathieu Berchel,Tony Le Gall,Pierre Haelters,Pierre Lehn,Tristan Montieret al. Molecular Pharmaceutics, 2015, 12 (6), pp.1902 - 1910. ⟨10.1021/mp500807k⟩ Article dans une revue hal-01537589v1
Biophysical properties of cationic lipophosphoramidates: Vesicle morphology, bilayer hydration and dynamics Damien Loizeau,Piotr Jurkiewicz,Gokcan Aydogan,Anatoly A. Philimonenko,Selim Mahfoudhiet al. Colloids and Surfaces B: Biointerfaces, 2015, 136, pp.192 - 200. ⟨10.1016/j.colsurfb.2015.09.012⟩ Article dans une revue istex hal-01538480v1
Atherton–Todd reaction: mechanism, scope and applications Stéphanie S Le Corre,Mathieu Berchel,Hélène Couthon,Jean-Pierre Haelters,Paul-Alain Jaffres Beilstein Journal of Organic Chemistry, 2014, 10, pp.1166 - 1196. ⟨10.3762/bjoc.10.117⟩ Article dans une revue hal-01517766v1
Effects of a Novel Archaeal Tetraether-based Colipid on the In Vivo Gene Transfer Activity of Two Cationic Amphiphiles Tony Le Gall,Julie Barbeau,Sylvain Barrier,Mathieu Berchel,Loïc Lemiègreet al. Molecular Pharmaceutics, 2014, 11 (9), pp.2973-2988. ⟨10.1021/mp4006276⟩ Article dans une revue hal-01027781v1
Functionalized Phospholipid Molecular Platform: Use for Production of Cationic Fluorescent Lipids Mathieu Berchel,Jean-Pierre Haelters,Damien Afonso,Alicia Maroto,Laure Burel-Deschampset al. European Journal of Organic Chemistry, 2014, 2014 (5), pp.1076 - 1083. ⟨10.1002/ejoc.201301416⟩ Article dans une revue istex hal-01531037v1
Lipopolyplexes comprising imidazole/imidazolium lipophosphoramidate, histidinylated polyethyleneimine and siRNA as efficient formulation for siRNA transfection Cristine Gonçalves,Mathieu Berchel,Marie-Pierre Gosselin,Virginie Malard,Hervé Cheradameet al. International Journal of Pharmaceutics, 2014, 460 (1-2), pp.264-272. ⟨10.1016/j.ijpharm.2013.11.005⟩ Article dans une revue istex hal-01179049v1
Cationic Trialkylphosphates: Synthesis and Transfection Efficacies Compared to Phosphoramidate Analogues Stéphanie Le Corre,Mathieu Berchel,Tony Le Gall,Pierre Haelters,Pierre Lehnet al. European Journal of Organic Chemistry, 2014, 2014 (36), pp.8041 - 8048. ⟨10.1002/ejoc.201403103⟩ Article dans une revue istex hal-01529608v1
DiGalactosyl-Glycero-Ether Lipid: synthetic approaches and evaluation as SK3 channel inhibitor. Charlotte Sevrain,Jean-Pierre Haelters,Aurélie Chantôme,Hélène Couthon,Maxime Gueguinouet al. Organic & Biomolecular Chemistry, 2013, 11 (27), pp.4479-87. ⟨10.1039/c3ob40634b⟩ Article dans une revue inserm-00848879v1
Cationic lipophosphoramidates with two different lipid chains: synthesis and evaluation as gene carriers Stéphanie Le Corre,Mathieu Berchel,Nawal Belmadi,Caroline Denis,Pierre Haelterset al. Organic & Biomolecular Chemistry, 2013, 12 (9), ⟨10.1039/C3OB42270D⟩ Article dans une revue hal-01531060v1
Silver-Phosphonate Based Metal Organic Frameworks: Synthesis and Antibacterial Action Mathieu Berchel,Sylvie Hernot,Hélène Couthon-Gourvès,Jean-Pierre Haelters,François Quentelet al. Phosphorus, Sulfur, and Silicon and the Related Elements, 2013, 188 (1-3), pp.76-78. ⟨10.1080/10426507.2012.741160⟩ Article dans une revue hal-05147748v1
Physicochemical properties of cationic lipophosphoramidates with an arsonium head group and various lipid chains: A structure–activity approach Damien Loizeau,Tony Le Gall,Sélim Mahfoudhi,Mathieu Berchel,Alicia Marotoet al. Biophysical Chemistry, 2013, 171, pp.46 - 53. ⟨10.1016/j.bpc.2012.10.003⟩ Article dans une revue istex hal-01555811v1
Trimethylarsonium-Based Cationic Phospholipids for Gene Delivery Mathieu Berchel,Stéphanie Le Corre,Tony Le Gall,Hélène Couthon,Jean-Pierre Haelterset al. Phosphorus, Sulfur, and Silicon and the Related Elements, 2013, 188 (1-3), pp.91-94. ⟨10.1080/10426507.2012.741161⟩ Article dans une revue hal-02070718v1
Cationic lipophosphoramidates with two disulfide motifs: synthesis, behaviour in reductive media and gene transfection activity Aurore Fraix,Tony Le Gall,Mathieu Berchel,Caroline Denis,Pierre Lehnet al. Organic & Biomolecular Chemistry, 2013, 11 (10), ⟨10.1039/C3OB27261C⟩ Article dans une revue hal-01555861v1
Arsonium-Containing Lipophosphoramides, Poly-Functional Nano-Carriers for Simultaneous Antibacterial Action and Eukaryotic Cell Transfection. Tony Le Gall,Mathieu Berchel,Sophie Le Hir,Aurore Fraix,Jean Yves Salaünet al. Adv Healthc Mater, 2013, epub ahead of print. ⟨10.1002/adhm.201200478⟩ Article dans une revue inserm-00824987v1
Pivotal Role of the Lipid Raft SK3-Orai1 Complex in Human Cancer Cell Migration and Bone Metastases. Aurélie Chantôme,Marie Potier-Cartereau,Lucie Clarysse,Gaëlle Fromont,Séverine Marionneau-Lambotet al. Cancer Research, 2013, epub ahead of print. ⟨10.1158/0008-5472.CAN-12-4572⟩ Article dans une revue inserm-00848873v1
Synthesis of lipophosphoramidyl-cyclodextrins and their supramolecular properties Cedric Gervaise,Véronique Bonnet,Olivier Wattraint,Fréderic Aubry,Catherine Sarazinet al. Biochimie, 2012, 94 (1), pp.66 - 74. ⟨10.1016/j.biochi.2011.09.005⟩ Article dans une revue istex hal-01559137v1
Structural Study of Hydrated/Dehydrated Manganese Thiophene-2,5-diphosphonate Metal Organic Frameworks, Mn 2 (O 3 P–C 4 H 2 S–PO 3 )·2H 2 O Jean-Michel Rueff,Olivier Perez,Alain Pautrat,Nicolas Barrier,Gary Hixet al. Inorganic Chemistry, 2012, 51 (19), pp.10251-10261. ⟨10.1021/ic301187y⟩ Article dans une revue hal-05147654v1
Copper(II) n-Alkylphosphonates Used as Nanofillers: Single Crystal, Powder Structure Studies and Influence of the Alkyl Chain Length on the Magnetic Properties Sophie Chausson,Jean-Michel Rueff,Marie Bernadette Lepetit,Olivier Perez,Richard Retouxet al. European Journal of Inorganic Chemistry, 2012, 2012 (13), pp.2193 - 2202. ⟨10.1002/ejic.201101218⟩ Article dans une revue istex hal-01556843v1
Gene transfer by histidylated lipopolyplexes: A dehydration method allowing preservation of their physicochemical parameters and transfection efficiency Federico Perche,Olivier Lambert,Mathieu Berchel,Paul-Alain Jaffres,Chantal Pichonet al. International Journal of Pharmaceutics, 2012, 423 (1), pp.144 - 150. ⟨10.1016/j.ijpharm.2011.04.009⟩ Article dans une revue istex hal-02995807v1
Gene transfer by chemical vectors, and endocytosis routes of polyplexes, lipoplexes and lipopolyplexes in a myoblast cell line. Ludivine Billiet,Jean-Pierre Gomez,Mathieu Berchel,Paul-Alain Jaffres,Tony Le Gallet al. Biomaterials, 2012, 33 (10), pp.2980-2990. ⟨10.1016/j.biomaterials.2011.12.027⟩ Article dans une revue istex hal-00721795v1
Glyco-Phospho-Glycero Ether Lipids (GPGEL): synthesis and evaluation as small conductance Ca2+-activated K+ channel (SK3) inhibitors Charlotte M. Sevrain,Jean-Pierre Haelters,Aurélie Chantôme,Hélène Couthon,Alban Giraultet al. MedChemComm, 2012, 3 (11), ⟨10.1039/C2MD20207G⟩ Article dans une revue hal-01556890v1
The gene transfection properties of a lipophosphoramidate derivative with two phytanyl chains Mattias F. Lindberg,Nathalie Carmoy,Tony Le Gall,Aurore Fraix,Mathieu Berchelet al. Biomaterials, 2012, 33 (26), pp.6240 - 6253. ⟨10.1016/j.biomaterials.2012.05.014⟩ Article dans une revue istex hal-01559108v1
Lipophosphonate/lipophosphoramidates: a family of synthetic vectors efficient for gene delivery. Mathieu Berchel,Tony Le Gall,Hélène Couthon,Jean-Pierre Haelters,Tristan Montieret al. Biochimie, 2012, 94 (1), pp.33-41. ⟨10.1016/j.biochi.2011.07.026⟩ Article dans une revue istex hal-00721772v1
A silver-based metal–organic framework material as a ‘reservoir’ of bactericidal metal ions Mathieu Berchel,Tony Le Gall,Céline Denis,Sophie Le Hir,François Quentelet al. New Journal of Chemistry, 2011, 35 (5), pp.1000-1003. ⟨10.1039/C1NJ20202B⟩ Article dans une revue hal-01577030v1
Targeting SKCa Channels in Cancer: Potential New Therapeutic Approaches Alban Girault,Jean-Pierre Haelters,Marie Potier-Cartereau,Aurélie Chantôme,Paul-Alain Jaffreset al. Current Medicinal Chemistry, 2011, sous presse. ⟨10.2174/092986712798992039⟩ Article dans une revue istex inserm-00662354v1
Selective gene delivery in dendritic cells with mannosylated and histidylated lipopolyplexes. Federico Perche,David Gosset,Mathieu Mével,Marie-Laure Miramon,Jean-Jacques Yaouancet al. Journal of Drug Targeting, 2011, 19 (5), pp.315-25. ⟨10.3109/1061186X.2010.504262⟩ Article dans une revue hal-00753554v1
Preparation and Flame Retardancy Properties of Novel PA12 and PE/Layered Titanoniobates Nanocomposites Sophie Chausson,Richard Retoux,Jean-Michel Rueff,Loïc Le Pluart,Pierre-Jean Madecet al. Macromolecular Symposia, 2011, 301 (1), pp.40-45. ⟨10.1002/masy.201150306⟩ Article dans une revue istex hal-02294620v1
New Lipo-Phosphoramidates for Gene Delivery Paul-Alain Jaffres,Aurore Fraix,Christophe Lorilleux,Mathieu Berchel,Hélène Couthonet al. Phosphorus, Sulfur, and Silicon and the Related Elements, 2011, 186 (4), pp.918-920. ⟨10.1080/10426507.2010.522639⟩ Article dans une revue hal-00614938v1
New Alkyl-Lipid Blockers of SK3 Channels Reduce Cancer Cell Migration and Occurrence of Metastasis Alain Girault,Jean-Pierre Haelters,Marie Potier-Cartereau,Aurélie Chantome,Michelle Pinaultet al. Current Cancer Drug Targets, 2011, 11 (9), pp.1111 - 1125. ⟨10.2174/156800911798073069⟩ Article dans une revue hal-01577240v1
Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA. Federico Perche,Thierry Benvegnu,Mathieu Berchel,Loic Lebegue,Chantal Pichonet al. Nanomedicine: Nanotechnology, Biology and Medicine, 2011, 7 (4), pp.445-53. ⟨10.1016/j.nano.2010.12.010⟩ Article dans une revue istex hal-00754373v1
Synthesis of Aryl-Thiophosphonates via A [1,2] or [1,3] Phospho-Fries Rearrangement Céline Denis,Aurore Fraix,Mathieu Berchel,Jean-Yves Salaün,Paul-Alain Jaffrès Phosphorus, Sulfur, and Silicon and the Related Elements, 2011, 186 (4), pp.790-791. ⟨10.1080/10426507.2010.520291⟩ Article dans une revue hal-05147551v1
Cationic lipo-thiophosphoramidates for gene delivery: synthesis, physico-chemical characterization and gene transfection activity – comparison with lipo-phosphoramidates Aurore Fraix,Tristan Montier,Nathalie Carmoy,Damien Loizeau,Laure Burel-Deschampset al. Organic & Biomolecular Chemistry, 2011, 9 (7), ⟨10.1039/C0OB00981D⟩ Article dans une revue hal-01577011v1
Lipothiophosphoramidates for gene delivery: critical role of the cationic polar headgroup Aurore Fraix,Tristan Montier,Tony Le Gall,Charlotte M. Sevrain,Nathalie Carmoyet al. Organic & Biomolecular Chemistry, 2011, 10 (10), ⟨10.1039/C2OB06812E⟩ Article dans une revue hal-01559125v1
Modular Construction of Fluorescent Lipophosphoramidates by Click Chemistry Mathieu Berchel,Jean-Piere Haelters,Hélène Couthon,Laure Burel-Deschamps,Patrick Midouxet al. European Journal of Organic Chemistry, 2011, 31, pp.6294-6303. ⟨10.1002/ejoc.201100900⟩ Article dans une revue istex hal-00720537v1
Rigid Aryl-Phosphonic Acids: Building Blocks for Hybrid Materials Paul-Alain Jaffrès,Hélène Couthon-Gourvès,Jean-Pierre Haelters,Gary Hix,Olivier Pérezet al. Phosphorus, Sulfur, and Silicon and the Related Elements, 2011, 186 (4), pp.906-907. ⟨10.1080/10426507.2010.520288⟩ Article dans une revue hal-05147525v1
DODAG; a versatile new cationic lipid that mediates efficient delivery of pDNA and siRNA Mathieu Mével,Nazila Kamaly,Sergio Carmona,Morag H. Oliver,Michael R. Jorgensenet al. Journal of Controlled Release, 2010, 143 (2), pp.222 - 232. ⟨10.1016/j.jconrel.2009.12.001⟩ Article dans une revue istex hal-01577311v1
Highly efficient gene transfer into hepatocyte-like HepaRG cells: new means for drug metabolism and toxicity studies Véronique Laurent,Aurore Fraix,Tristan Montier,Sandrine Cammas-Marion,Catherine Ribaultet al. Biotechnology Journal, 2010, 5 (3), pp.314. ⟨10.1002/biot.200900255⟩ Article dans une revue hal-00552337v1
Construction of a monoanionic S,N,S-pincer ligand with a pyrrole core by sequential [1,2] phospho-Fries rearrangement. Characterization of palladium and silver coordination complexes Aurore Fraix,Martin Lutz,Anthony L. Spek,Robertus J. M. Klein Gebbink,Gerard van Kotenet al. Dalton Transactions, 2010, 39 (11), ⟨10.1039/B923351B⟩ Article dans une revue istex hal-01577325v1
An unexpected base-induced [1,4]-phospho-Fries rearrangement Mathieu Berchel,Jean-Yves Salaün,Hélène Couthon,Jean-Pierre Haelters,Paul-Alain Jaffres Dalton Transactions, 2010, 39 (47), ⟨10.1039/C0DT00880J⟩ Article dans une revue istex hal-01577411v1
A Novel Cationic Lipophosphoramide with Diunsaturated Lipid Chains: Synthesis, Physicochemical Properties, and Transfection Activities Tony Le Gall,Damien Loizeau,Erwan Picquet,Nathalie Carmoy,Jean-Jacques Yaouancet al. Journal of Medicinal Chemistry, 2010, 53 (4), pp.1496 - 1508. ⟨10.1021/jm900897a⟩ Article dans une revue hal-01577317v1
Green Synthesis of Poly(aminomethylenephosphonic) Acids Didier Didi,Bernard Moreau,Abdelghani Elbilali,Mohamed-Amine Didi,M’hamed Kaidet al. Phosphorus, Sulfur, and Silicon and the Related Elements, 2010, 185 (12), pp.2511 - 2519. ⟨10.1080/10426501003724897⟩ Article dans une revue hal-01577409v1
Synthesis of Methylene Bisphosphonates from Carbon Disulfide and Phosphites via Desulfurization: A Mechanistic Study B. Heuzé,M. Lemarié,M. Vazeux,M. Gulea,S. Massonet al. Phosphorus, Sulfur, and Silicon and the Related Elements, 2009, 184 (4), pp.820 - 829. ⟨10.1080/10426500802715528⟩ Article dans une revue hal-01579807v1
Remarkable thermal stability of Eu(4-phosphonobenzoate): structure investigations and luminescence properties Jean-Michel Rueff,Nicolas Barrier,Sophie Boudin,Vincent Dorcet,Vincent Caignaertet al. Dalton Transactions, 2009, 47, ⟨10.1039/b913590c⟩ Article dans une revue istex hal-01580248v1
Phosphine Addition to Pyruvoyl Ligands of Iron Complexes: Formation of Zwitterionic Metallalactones J. Y. Salaün,R. Rumin,F. Setifi,Smail Triki,Paul-Alain Jaffres Organometallics, 2009, 28 (1), pp.216 - 224. ⟨10.1021/om800804b⟩ Article dans une revue hal-01578077v1
Elaboration and characterization of novel polyamide-12-layered titanoniobates nanocomposites Sophie Chausson,Richard Retoux,Jean-Michel Rueff,Loïc Le Pluart,Pierre-Jean Madecet al. Journal of Materials Research, 2009, 24 (11), pp.3358 - 3371. ⟨10.1557/jmr.2009.0410⟩ Article dans une revue istex hal-01580240v1
Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers Patrick Midoux,Chantal Pichon,Jean-Jacques Yaouanc,Paul-Alain Jaffres British Journal of Pharmacology, 2009, 157 (2), pp.166-178. ⟨10.1111/j.1476-5381.2009.00288.x⟩ Article dans une revue hal-00525108v1
Synthesis of Phosphorus-Containing Chitosan Derivatives Fanny Lebouc,Isabelle Dez,Mihaela Gulea,Pierre-Jean Madec,Paul-Alain Jaffres Phosphorus, Sulfur, and Silicon and the Related Elements, 2009, 184 (4), pp.872 - 889. ⟨10.1080/10426500802715585⟩ Article dans une revue hal-01580233v1
The dimeric unit [La(H2O)4(m-PO3C6H4COOH)(m-PO2(OH)C6H4COOH)(m-PO(OH)2C6H4COOH)]2 as building block of layered hybrid material Jean-Michel Rueff,André Leclaire,Paul-Alain Jaffres Solid State Sciences, 2009, 11 (4), pp.812 - 817. ⟨10.1016/j.solidstatesciences.2008.12.008⟩ Article dans une revue istex hal-01578097v1
m-phosphonobenzoic acid and copper(II) as precursors of helical chain and lamellar hybrid materials Jean-Michel Rueff,Vincent Caignaert,André Leclaire,Charles Simon,Jean-Pierre Haelterset al. CrystEngComm, 2009, 11 (4), ⟨10.1039/B816132C⟩ Article dans une revue istex hal-01578094v1
3,5-Diphosphonobenzoic Acid, a New Rigid Heterotrifunctional Building Block to Design Metal Organic Frameworks. Illustration with the Characterization of Cu 5 [(O 3 P) 2 -C 6 H 3 -CO 2 ] 2 (H 2 O) 6 Jean-Michel Rueff,Olivier Perez,Charles Simon,Christophe Lorilleux,Hélène Couthonet al. Crystal Growth & Design, 2009, 9 (10), pp.4262 - 4268. ⟨10.1021/cg900811k⟩ Article dans une revue hal-01580253v1
Application of a base-induced [1,2]-rearrangement to synthesize thiophosphonate bidentate S(sp2)–N monoanionic ligand: Characterization of its silver and palladium complexes Sabrina Marie,Martin Lutz,Anthony L. Spek,Robertus J.M. Klein Gebbink,Gerard van Kotenet al. Journal of Organometallic Chemistry, 2009, 694 (25), pp.4001 - 4007. ⟨10.1016/j.jorganchem.2009.08.035⟩ Article dans une revue istex hal-01580243v1
Lead(II) Hybrid Materials from 3- or 4-Phosphonobenzoic Acid Jean-Michel Rueff,Olivier Perez,André Leclaire,Hélène Couthon,Paul-Alain Jaffres European Journal of Inorganic Chemistry, 2009, 2009 (32), pp.4870 - 4876. ⟨10.1002/ejic.200900430⟩ Article dans une revue istex hal-01580241v1
Synthesis of functionalized alkoxyalkylidene gem-bisphosphonates Jean-Pierre Haelters,Hélène Couthon,Alan Le Goff,Gaelle Simon,Bernard Corbelet al. Tetrahedron, 2008, 64 (27), pp.6537 - 6543. ⟨10.1016/j.tet.2008.04.052⟩ Article dans une revue istex hal-01580463v1
An Efficient and Straightforward Access to Sulfur Substituted [2.2]Paracyclophanes: Application to Stereoselective Sulfenate Salt Alkylation Jean-François Lohier,Florian Foucoin,Paul-Alain Jaffres,José I. Garcia,Jana Sopkova-de Oliveira Santoset al. Organic Letters, 2008, 10 (6), pp.1271 - 1274. ⟨10.1021/ol800161m⟩ Article dans une revue hal-01580460v1
Synthesis and transfection activity of new cationic phosphoramidate lipids: High efficiency of an imidazolium derivative M. Mevel,Gilles Breuzard,J.-J. Yaouanc,J.-C. Clement,P. Lehnet al. ChemBioChem, 2008, 9 (9), pp.1462-1471. ⟨10.1002/cbic.200700727⟩ Article dans une revue istex hal-00518184v1
Polyethylene nanocomposites based on intercalation of N-alkyl amines within KTiNbO5 structure Sophie Chausson,Vincent Caignaert,Richard Retoux,Jean-Michel Rueff,Loïc Le Pluartet al. Polymer, 2008, 49 (2), pp.488 - 496. ⟨10.1016/j.polymer.2007.11.050⟩ Article dans une revue istex hal-01580385v1
New Polyamines Phosphoramidate Vectors for Gene Therapy Mathieu Mével,François Lamarche,Jean-Claude Clément,Pascal Laurent,Jean-Jacques Yaouancet al. Phosphorus, Sulfur, and Silicon and the Related Elements, 2008, 183 (2-3), pp.623 - 624. ⟨10.1080/10426500701793303⟩ Article dans une revue hal-01580437v1
Fluorescence Study of Lipid-based DNA Carriers Properties: Influence of Cationic Lipid Chemical Structure Laure Burel-Deschamps,Mathieu Mével,Damien Loizeau,Farouk Ayadi,Jean-Jacques Yaouancet al. Journal of Fluorescence, 2008, 18 (5), pp.835 - 841. ⟨10.1007/s10895-008-0312-7⟩ Article dans une revue istex hal-01580489v1
(N,N) vs. (N,S) chelation of palladium in asymmetric allylic substitution using bis(thiazoline) ligands: A theoretical and experimental study Alexander Betz,Lian Yu,Markus Reiher,Annie-Claude Gaumont,Paul-Alain Jaffreset al. Journal of Organometallic Chemistry, 2008, 693 (15), pp.2499 - 2508. ⟨10.1016/j.jorganchem.2008.04.044⟩ Article dans une revue istex hal-01580466v1
Synthesis, Crystal Structure and Thermal Properties of Phosphorylated Cyclotriphosphazenes Nicolas Lejeune,Isabelle Dez,Paul-Alain Jaffres,Jean-François Lohier,Pierre-Jean Madecet al. European Journal of Inorganic Chemistry, 2008, 2008 (1), pp.138 - 143. ⟨10.1002/ejic.200700785⟩ Article dans une revue istex hal-01580304v1
Ethane-1,1,2-trisphosphonic acid hemihydrate Lise Delain-Bioton,Jean-François Lohier,Didier Villemin,Jana Sopkova-de Oliveira Santos,Gary Hixet al. Acta Crystallographica Section C : Crystal Structure Communications [1968-2013], 2008, 64 (2), pp.o47 - o49. ⟨10.1107/S0108270107064098⟩ Article dans une revue istex hal-01580382v1
Progress in Cationic Lipid-Mediated Gene Transfection: A Series of Bio- Inspired Lipids as an Example T. Montier,Thierry Benvegnu,Paul-Alain Jaffres,J.-J. Yaouanc,Pierre Lehn Current Gene Therapy, 2008, 8, pp.296-312. ⟨10.2174/156652308786070989⟩ Article dans une revue hal-00403363v1
Phosphorus Functionalized Carbenes: Synthesis and Coordination Properties Didier Morvan,Jean-François Capon,Frederic Gloaguen,Philippe P. Schollhammer,Jean Talarminet al. Phosphorus, Sulfur, and Silicon and the Related Elements, 2008, 183 (2-3), pp.669 - 670. ⟨10.1080/10426500701796306⟩ Article dans une revue hal-01580438v1
Synthesis of O,O -Diethyl Arylthiophosphonate from O -Aryl- O , O -diethylthiophosphate Thierno Dieng,Aurore Fraix,Jean-Yves Salaün,Isabelle Dez,Robertus Klein Gebbinket al. SYNLETT, 2008, 2008 (20), pp.3121 - 3124. ⟨10.1055/s-0028-1087362⟩ Article dans une revue hal-01580497v1
New Phosphoramidate Dicationic Vectors for Gene Therapy Mathieu Mével,François Lamarche,Jean-Claude Clément,Jean-Jacques Yaouanc,Pascale Laurentet al. Phosphorus, Sulfur, and Silicon and the Related Elements, 2008, 183 (2-3), pp.745-746. ⟨10.1080/10426500701807764⟩ Article dans une revue hal-05142701v1
Novel neutral imidazole-lipophosphoramides for transfection assays M. Mevel,C. Neveu,Cristine Goncalves,J.-J. Yaouanc,Chantal Pichonet al. Chemical Communications, 2008, 27, pp.3124-3126. ⟨10.1039/b805226c⟩ Article dans une revue istex hal-00518192v1
Progress in cationic lipid-mediated gene transfection: a series of bio-inspired lipids as an example. Tristan Montier,Thierry Benvegnu,Paul-Alain Jaffres,Jean-Jacques Yaouanc,Pierre Lehn Current Gene Therapy, 2008, pp.296-312 Article dans une revue hal-01580475v1
meta -Phosphonobenzoic Acid: A Rigid Heterobifunctional Precursor for the Design of Hybrid Materials Jean-Michel Rueff,Vincent Caignaert,Sophie Chausson,André Leclaire,Charles Simonet al. European Journal of Inorganic Chemistry, 2008, 2008 (26), pp.4117 - 4125. ⟨10.1002/ejic.200800483⟩ Article dans une revue istex hal-01580472v1
Cationic Lipids Based on Phosphonate and Phosphoramidate Chemistry: Synthesis and Application to Gene Therapy Mathieu Mével,Jean-Jacques Yaouanc,Pascal Laurent,Claude Clément,Dominique Cartieret al. Phosphorus, Sulfur, and Silicon and the Related Elements, 2008, 183 (2-3), pp.460-468. ⟨10.1080/10426500701761300⟩ Article dans une revue hal-01580434v1
Lipophosphoramidates as Lipidic Part of Lipospermines for Gene Delivery François Lamarche,Mathieu Mével,Tristan Montier,Laure Burel-Deschamps,Philippe Giamarchiet al. Bioconjugate Chemistry, 2007, 18 (5), pp.1575-1582. ⟨10.1021/bc070070w⟩ Article dans une revue istex hal-01581383v1
Dicationic Lipophosphoramidates as DNA Carriers Mathieu Mével,Tristan Montier,François Lamarche,Pascal Delépine,Tony Le Gallet al. Bioconjugate Chemistry, 2007, 18 (5), pp.1604 - 1611. ⟨10.1021/bc070089z⟩ Article dans une revue istex hal-01581379v1
Diastereoselective Michael additions to α,β-unsaturated α-sulfinyl phosphonates in the thiolane series Piotr Łyżwa,Aleksandra Jankowiak,Małgorzata Kwiatkowska,Marian Mikołajczyk,Piotr Kiełbasińskiet al. Tetrahedron Letters, 2007, 48 (3), pp.351 - 355. ⟨10.1016/j.tetlet.2006.11.098⟩ Article dans une revue istex hal-01581424v1
Status report on organo-metallic beams at GANIL P. Léhérissier,C. Barué,C. Canet,M. Dubois,M. Dupuiset al. High Energy Physics and Nuclear Physics -Beijing-, 2007, 31, pp.85-89 Article dans une revue hal-01581436v1
A Supramolecular Ladderlike Structure Formed by the Auto-Assembly of Benzene-1,3,5-triphosphonic Acid Gary B. Hix,Vincent Caignaert,Jean-Michel Rueff,Loïc Le Pluart,John E. Warrenet al. Crystal Growth & Design, 2007, 7 (2), pp.208 - 211. ⟨10.1021/cg060813k⟩ Article dans une revue hal-01581263v1
Synthesis of triazolyl-alkylphosphonate starting from ω-azidoalkylphosphonates or ω-alkynylphosphonates Lise Delain-Bioton,Didier Villemin,Jean-François Lohier,Jana Sopkova-de Oliveira Santos,Paul-Alain Jaffres Tetrahedron, 2007, 63 (39), pp.9677 - 9684. ⟨10.1016/j.tet.2007.07.024⟩ Article dans une revue istex hal-01581417v1
RAPID AND EFFICIENT ARBUZOV REACTION UNDER MICROWAVE IRRADIATION Didier Villemin,Fabrice Simeon,Hugues Decreus,Paul-Alain Jaffrès Phosphorus, Sulfur, and Silicon and the Related Elements, 2006, 133 (1), pp.209-213. ⟨10.1080/10426509808032465⟩ Article dans une revue hal-05141474v1
Design of Sulfides with a Locked Conformation as Promoters of Catalytic and Asymmetric Sulfonium Ylide Epoxidation Marion Davoust,Jean-François Brière,Paul-Alain Jaffrès,Patrick Metzner Journal of Organic Chemistry, 2005, 70 (10), pp.4166-4169. ⟨10.1021/jo0479260⟩ Article dans une revue istex hal-05142610v1
Michael addition of phosphorus derivatives on tetraethyl ethylidenediphosphonate Lise Delain-Bioton,Adele Turner,Nicolas Lejeune,Didier Villemin,Gary Hixet al. Tetrahedron, 2005, 61 (27), pp.6602-6609. ⟨10.1016/j.tet.2005.04.045⟩ Article dans une revue hal-05142645v1
Assembly of benzene-1,3,5-tris(methylenephosphonic acid) and guanidinium salt: Single crystal-X-ray characterisation and 31P, solid state NMR investigations Jana Sopkova-de Oliveira Santos,V. Montouillout,F. Fayon,Christian Fernandez,L. Delain-Biotonet al. New Journal of Chemistry, 2004, 28 (10), pp.1244-1249. ⟨10.1039/b406938b⟩ Article dans une revue istex hal-01711628v1
Synthesis of 4-Arylideneisochroman-1,3-Dione under Microwave Irradiation Didier Villemin,Nathalie Bar,Mohamed Khalid,Paul-Alain Jaffrès,Jana Sopkova-de Oliveira Santos Journal of Chemical Research, 2003, 2003 (7), pp.433-435. ⟨10.3184/030823403103174425⟩ Article dans une revue hal-05142579v1
Nickel and Palladium Catalysed Reaction of Triethyl Phosphite with Aryl Halides under Microwave Irradiation Didier Villemin,Abdelghani Elbilali,Fabrice Siméon,Paul-Alain Jaffrès,Géraldine Maheutet al. Journal of Chemical Research, 2003, 2003 (7), pp.436-437. ⟨10.3184/030823403103174434⟩ Article dans une revue hal-05142569v1
Palladium complex immobilised on zirconium-phosphite: Characterisation by 31P MAS NMR and TEM and behaviour towards reducing agents G. Maheut,M. Hervieu,Christian Fernandez,V. Montouillout,D. Villeminet al. Journal of Molecular Structure, 2003, 659 (1-3), pp.135-142. ⟨10.1016/s0022-2860(03)00409-5⟩ Article dans une revue istex hal-01711630v1
Hydrothermal synthesis and crystal structure of two Co phosphonates containing trifunctional phosphonate anions: Co3(O3PCH2NH2CH2PO3)2 and Co3(O3PCH2-NC4H7-CO2)2·5H2O Adele Turner,Paul-Alain Jaffrès,Elizabeth Maclean,Didier Villemin,Vickie Mckeeet al. Dalton Transactions, 2003, 7, pp.1314-1319. ⟨10.1039/B212266A⟩ Article dans une revue hal-05142544v1
Self-association of benzene-1,3,5-tris-(methylenephosphonic acid): Evidence of charge-assisted hydrogen bonds P.-A. Jaffrès,D. Villemin,V. Montouillout,Christian Fernandez Fernandez,J. Chardonet al. Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 2002, 389 (PART I), pp.87-95. ⟨10.1080/713738902⟩ Article dans une revue hal-01711633v1
Synthesis of Substituted Butenolides. An Undergraduate Organic Laboratory Experiment Utilizing Two 3-Step Preparatory Sequences Géraldine Maheut,Liang Liao,Jean-Marie Catel,Paul-Alain Jaffrès,Didier Villemin Journal of Chemical Education, 2001, 78 (5), pp.654. ⟨10.1021/ed078p654⟩ Article dans une revue hal-05141684v1
Synthesis of aldehyde functionalised polyhedral oligomeric silsesquioxanes Bruce Manson,John Morrison,Pamela Coupar,Paul-Alain Jaffrès,Russell Morris Journal of the Chemical Society Dalton Transactions, 2001, 7, pp.1123-1127. ⟨10.1039/B100568P⟩ Article dans une revue hal-05141675v1
Potassium exchanged zirconium hydrogen phosphate Zr(O3POK)2: a heterogeneous basic catalyst for Knoevenagel reaction without solvent David Fildes,Didier Villemin,Paul-Alain Jaffrès,Vincent Caignaert Green Chemistry, 2001, 3 (1), pp.52-56. ⟨10.1039/B009199P⟩ Article dans une revue hal-05141660v1
Dehydration/amine intercalation in Zn(O3PR)–H2O phosphonates: the missing link, X-ray structure of Zn(O3PCH3) Martine Bujoli-Doeuff,Michel Evain,Paul-Alain Jaffrès,Vincent Caignaert,Bruno Bujoli International Journal of Inorganic Materials, 2000, 2 (6), pp.557-560. ⟨10.1016/S1466-6049(00)00081-7⟩ Article dans une revue hal-05141537v1
A direct access to layered zirconium-phosphonate materials from dialkylphosphonates Paul-Alain Jaffrès,Didier Villemin,Vincent Caignaert Chemical Communications, 1999, 19, pp.1997-1998. ⟨10.1039/A905354I⟩ Article dans une revue hal-05141508v1
Synthesis and characterisation of silanol-functionalised dendrimers † Pamela Coupar,Paul-Alain Jaffrès,Russell Morris Journal- Chemical Society Dalton Transactions, 1999, 13, pp.2183-2188. ⟨10.1039/A901962F⟩ Article dans une revue hal-05141518v1
Phosphonation of 1,1′-binaphthalene-2,2′-diol (BINOL): synthesis of (R)- and (S )-2,2′-dihydroxy-1,1′-binaphthalene-6,6′-diyldiphosphonic acid Paul-Alain Jaffrès,Nathalie Bar,Didier Villemin Journal of the Chemical Society, Perkin Transactions 1, 1998, 13, pp.2083-2090. ⟨10.1039/A801522H⟩ Article dans une revue hal-05141502v1
A direct and new convenient oxidation: Synthesis of substituted arylphosphonates from aromatics Fabrice Siméon,Paul-Alain Jaffrès,Didier Villemin Tetrahedron, 1998, 54 (34), pp.10111-10118. ⟨10.1016/S0040-4020(98)00601-2⟩ Article dans une revue istex hal-05141493v1
Synthesis of highly functionalised dendrimers based on polyhedral silsesquioxane cores † Paul-Alain Jaffrès,Russell Morris Journal- Chemical Society Dalton Transactions, 1998, 16, pp.2767-2770. ⟨10.1039/A801510D⟩ Article dans une revue istex hal-05141466v1
An abnormal reaction of esters of 3-hydroxy-3-methylbutan-2-one. A rapid synthesis of bullatenone and geiparvarin Didier Villemin,Paul-Alain Jaffrès,Messaoud Hachémi Tetrahedron Letters, 1997, 38 (4), pp.537-538. ⟨10.1016/S0040-4039(96)02365-9⟩ Article dans une revue hal-05139739v1
Palladium complexes supported on hybrid organic-inorganic zirconium phosphite: selectivity in the Heck reaction Didier Villemin,Paul-Alain Jaffrès,Belkacem Nechab,Fréderic Courivaud Tetrahedron Letters, 1997, 38 (37), pp.6581-6584. ⟨10.1016/S0040-4039(97)01505-0⟩ Article dans une revue hal-05139767v1
RAPID AND EFFICIENT PHOSPHONATION OF ARYL HALIDES CATALYSED BY PALLADIUM UNDER MICROWAVES IRRADIATION Didier Villemin,Paul-Alain Jaffrès,Fabrice Siméon Phosphorus, Sulfur, and Silicon and the Related Elements, 1997, 130 (1), pp.59-63. ⟨10.1080/10426509708033697⟩ Article dans une revue hal-05139749v1

Communication dans un congrès (11)

Synthetic phospholipids for nucleic acid delivery Chloé Le Roux,Mathieu Berchel,Paul-Alain Jaffrès,Véronique Vié,Gilles Paboeufet al. ACS Fall 2024, American Chemical Society, Aug 2024, Denver (Colorado), United States Communication dans un congrès hal-05096661v1
Spectroscopic studies of rare-earth free hybrids derived from thianthrene-phosphonic acid Parameshwari Ganesan,Geoffrey Letheux,C. Labbe,Jean-Michel Rueff,Paul-Alain Jaffrèset al. 20th International Conference on Luminescence, Aug 2023, Paris, France Communication dans un congrès hal-05565789v1
Conception de composés lipidiques pour le transport d’acides nucléiques Chloé Le Roux,Paul-Alain Jaffrès,Mathieu Berchel,Véronique Vié,Gilles Paboeuf Colloque IBSAM, Jun 2023, Brest, France Communication dans un congrès hal-05096709v1
OS04-03 Gene transfer in differentiated HepaRG™ cells: Application to the modulation of specific hepatocyte functions H. Coppens-Exandier,M. Vlach,I. Ouhssain,M. Berchel,Tristan Montieret al. 57th Congress of the European Societies of Toxicology (EUROTOX 2023), Sep 2023, Ljubljana, Slovenia. pp.S72-S73, ⟨10.1016/s0378-4274(23)00440-x⟩ Communication dans un congrès hal-04358374v1
Gene transfer in differentiated HepaRGT cells: Application to the modulation of specific hepatocyte functions H. Coppens-Exandier,M. Vlach,I. Ouhssain,M. Berchel,T. Montieret al. 57th Congress of the European-Societies-of-Toxicology (EUROTOX), Sep 2023, Ljubljana, Slovenia Communication dans un congrès hal-04329132v1
Spectroscopic studies of hybrids derived from organic-phosphonic acid with alkaline earth elements (Mg, Ca, Sr, Ba) Parameshwari Ganesan,Geoffrey Letheux,C. Labbe,Jean-Michel Rueff,Paul-Alain Jaffrèset al. E-MRS Spring Meeting, EMRS, May 2023, Strasbourg, France Communication dans un congrès hal-05565793v1
Spectroscopic studies of new series of alkaline earth elements (Mg, Ca, Sr, Ba) correlated metallophosphonates Parameshwari Ganesan,Geoffrey Letheux,Christophe Labbé,Olivier Perez,Jean-Michel Rueffet al. SPIE Photonics Europe, Organic Electronics and Photonics: Fundamentals and Devices III, Apr 2022, Strasbourg, France. pp.55, ⟨10.1117/12.2621565⟩ Communication dans un congrès hal-04076101v1
Synthesis in water under Focussed Microwave Irradiation: a Rapid and Convenient Synthesis of Polyaminopolymethylenephosphonic acids D. Villemin,Bernard Moreau,Mohamed Amine Didi,M’hamed Kaid,Paul-Alain Jaffrès 12th international Electronic Conference on Synthetic Organic Chemistry (ECSOC-12), Nov 2008, En ligne, France Communication dans un congrès hal-05142740v1
TEM/SEM characterisation of hybrid titanoniobiates used as fillers for thermoplastic nanocomposites Richard Retoux,Sophie Chausson,Loïc Le Pluart,Jean-Michel Rueff,Paul-Alain Jaffrès EMC 2008, 14th European Microscopy Congress, Sep 2008, Aachen, Germany Communication dans un congrès hal-05145457v1
Status report on organo-metallic beams at GANIL P. Lehérissier,C. Barué,C. Canet,M. Dubois,J.L. Flambardet al. 17th International Workshop on ECR Ion Sources and Their Applications : ECRIS 06, Sep 2006, Lanzhou, China. 85-89 Suppl. 1 Communication dans un congrès in2p3-00173789v1
High intensity metallic ion beams from an ECR ions source at GANIL P. Lehérissier,C. Barué,C. Canet,M. Dupuis,J.L. Flambardet al. International Conference on Ion Sources 9, Sep 2001, Oakland, United States. pp.558-560 Communication dans un congrès in2p3-00012740v1

Poster de conférence (1)

Design of lipidic compounds for nucleic acid delivery - Physico-chemical studies Chloé Le Roux,Gilles Paboeuf,Véronique Vié,Mathieu Berchel,Paul-Alain Jaffrès Journée de l'école doctorale ED-S3M, May 2024, Rennes, France Poster de conférence hal-05096756v1

Proceedings/Recueil des communications (3)

Synthetic Phospholipids for pDNA Delivery and Antibacterial Action Damien Afonso,Stéphanie Le Corre,Mathieu Berchel,Hélène Couthon-Gourvès,Tony Le Gallet al. 20th International Conference on Phosphorus Chemistry, Jun 2014, Dublin, France. Phosphorus, Sulfur, and Silicon and the Related Elements, 190 (5-6), pp.754-757, 2015, ⟨10.1080/10426507.2014.980410⟩ Proceedings/Recueil des communications hal-05149450v1
Study of the Stability of O,O -Dialkyl- O -Arylthiophosphate: Evidence of the Formation of O,S -Dialkyl- O -Arylphosphate Stéphanie Le Corre,Aurore Fraix,Mathieu Berchel,Paul-Alain Jaffrès 20th International Conference on Phosphorus Chemistry (ICPC2014), Jun 2014, Dublin, France. Phosphorus, Sulfur, and Silicon and the Related Elements, 190 (5-6), pp.747-750, 2015, ⟨10.1080/10426507.2014.974751⟩ Proceedings/Recueil des communications hal-05149459v1
Influence of the Lipid Domain on the Supramolecular Assemblies of Cationic Lipids. Characterization by Solid-State 31P and 2H NMR Spectroscopy Damien Afonso,Hélène Couthon,Mathieu Berchel,Axelle Grelard,Erick J. Dufourcet al. 20th International Conference on Phosphorus Chemistry (ICPC2014), Jun 2014, Dublin, France. Phosphorus, Sulfur, and Silicon and the Related Elements, 190 (5-6), pp.896-898, 2015, ⟨10.1080/10426507.2014.974750⟩ Proceedings/Recueil des communications hal-02123944v1

Chapitre d'ouvrage (4)

Phosphonate-based amphiphiles for nucleic acid delivery Chloé Le Roux,Mathieu Berchel,Paul-Alain Jaffrès Konstantinos D. Demadis. Phosphonate chemistry, Technology and applications, Synthesis, chemistry and biomedical applications., Elsevier, pp.411-425, 2026, 978-0-443-33374-3. ⟨10.1016/B978-0-443-33374-3.00036-0⟩ Chapitre d'ouvrage hal-05415528v1
Recent Developments in Phosphonium Chemistry Mathieu Berchel,Paul-Alain Jaffres Viktor Iaroshenko. Organophosphorus Chemistry: From Molecules to Applications (2019), 2, Wiley- VCH, pp.59-102, 2019, 978-3-527-33572-5. ⟨10.1002/9783527672240.ch2⟩ Chapitre d'ouvrage hal-01980734v1
Aerosol Delivery to the Airways Using Cationic Lipid Nanocomplexes in a Perspective of Cystic Fibrosis Treatment Mathieu Berchel,Paul-Alain Jaffres,Tony Le Gall,Tristan Montier Targeted Nanosystems for Therapeutic Applications: New Concepts, Dynamic Properties, Efficiency, and Toxicity, 1309 (Chapitre 2), Kazuo Sakurai; Marc A. Ilies, pp.35-58, 2019, ACS Symposium Series, ISBN13: 9780841233836 ; eISBN: 9780841233744. ⟨10.1021/bk-2019-1309.ch002⟩ Chapitre d'ouvrage hal-02079347v1
Rigid Phosphonic Acids as Building Blocks for Crystalline Hybrid Materials Jean-Michel Rueff,Gary B. Hix,Paul-Alain Jaffres Ernesto Brunet Jorge L. Colón Abraham Clearfield. Tailored Organic-Inorganic Materials, chapitre 9, Wiley-CH, pp.341-393, 2015, 978-1-118-77346-8. ⟨10.1002/9781118792223.ch9⟩ Chapitre d'ouvrage hal-02127158v1

Brevet (3)

Novel branched amphiphilic lipids Paul-Alain Jaffres,Hélène Couthon,Damien Afonso,Tristan Montier,Tony Le Gall France, Patent n° : WO2017051129 A1. 2015 Brevet hal-01532123v1
MODULAR CONSTRUCTION OF LIPOPHOSPHOLIPIDS Jean-Pierre Haelters,Mathieu Berchel,Hélène Couthon,Paul-Alain Jaffres France, Patent n° : WO 2012004419 A2. 2012 Brevet hal-01620524v1
Thiophosphoramidates : une nouvelle famille de lipides pour la vectorisation d’acides nucléiques Aurore Fraix,Tristan Montier,Pierre Lehn,Paul-Alain Jaffres United States, Patent n° : 61/389,959. 2010 Brevet hal-01577436v1