Philippe Arnaud

Présentation

Depuis 01/2012- GReD, CNRS-UCA-INSERM,Clermont-Ferrand

2004-2011 IGMM CNRS UMR5535, Montpellier

2000-2003 Babraham Institute, Cambridge, UK

1996-2000 Biomove, Université Blaise Pascal, Clermont-Ferrand.

Publications

Article dans une revue (51)

PIK3R1 and G0S2 are human placenta-specific imprinted genes associated with germline-inherited maternal DNA methylation Dagne Daskeviciute,Becky Sainty,Louise Chappell-Maor,Caitlin Bone,Sarah Russellet al. Epigenetics, 2025, 20 (1), pp.2523191. ⟨10.1080/15592294.2025.2523191⟩ Article dans une revue hal-05343990v1
The superpowers of imprinting control regions Bertille Montibus,Franck Court,Philippe P. Arnaud Genome Research, 2025, 35, pp.1-19. ⟨10.1101/gr.281215.125⟩ Article dans une revue hal-05424162v1
Non-canonical imprinting, manifesting as post-fertilization placenta-specific parent-of-origin dependent methylation, is not conserved in humans Dagne Daskeviciute,Louise Chappell-Maor,Becky Sainty,Philippe P. Arnaud,Isabel Iglesias-Plataset al. Human Molecular Genetics, In press, ⟨10.1093/hmg/ddaf009⟩ Article dans une revue hal-04961461v1
Biallelic non-productive enhancer-promoter interactions precede imprinted expression of Kcnk9 during mouse neural commitment Cecilia Rengifo Rojas,Jil Cercy,Sophie Perillous,Céline Gonthier-Guéret,Bertille Montibuset al. Human Genetics and Genomics Advances, 2024, 5 (2), pp.100271. ⟨10.1016/j.xhgg.2024.100271⟩ Article dans une revue hal-04444966v2
The Long Non-Coding RNA HOXA-AS2 Promotes Proliferation of Glioma Stem Cells and Modulates Their Inflammation Pathway Mainly through Post-Transcriptional Regulation Elisa Le Boiteux,Pierre-Olivier Guichet,Konstantin Masliantsev,Bertille Montibus,Catherine Vaurs-Barriereet al. International Journal of Molecular Sciences, 2022, 23 (9), pp.4743. ⟨10.3390/ijms23094743⟩ Article dans une revue hal-03668886v1
Variable allelic expression of imprinted genes at the Peg13, Trappc9, Ago2 cluster in single neural cells Michael Claxton,Antonius Plagge,Ralph Bernardo,Peng Zhou,Daniel M Messerschmidtet al. Frontiers in Cell and Developmental Biology, 2022, 10, ⟨10.3389/fcell.2022.1022422⟩ Article dans une revue hal-03811612v1
Widespread overexpression from the four DNA hypermethylated HOX clusters in aggressive (IDHwt) glioma is associated with H3K27me3 depletion and alternative promoter usage Elisa Le Boiteux,Franck Court,Pierre‐Olivier Guichet,Catherine Vaurs-Barrière,Isabelle Vaillantet al. Molecular Oncology, 2021, ⟨10.1002/1878-0261.12944⟩ Article dans une revue hal-03172071v1
TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment Bertille Montibus,Jil Cercy,Tristan Bouschet,Amandine Charras,Stéphanie Maupetit-Méhouaset al. Cellular and Molecular Life Sciences, 2020, 78 (2), pp.757-768. ⟨10.1007/s00018-020-03541-8⟩ Article dans une revue hal-02863871v1
HOX gene cluster (de)regulation in brain: from neurodevelopment to malignant glial tumours Céline S Gonçalves,Elisa Le Boiteux,Philippe P. Arnaud,Bruno Costa Cellular and Molecular Life Sciences, 2020, ⟨10.1007/s00018-020-03508-9⟩ Article dans une revue hal-02570662v1
Transcriptional alterations in glioma result primarily from DNA methylation independent mechanisms Franck Court,Elisa Le Boiteux,Anne Fogli,Mélanie Müller-Barthélémy,Catherine Vaurs-Barrièreet al. Genome Research, 2019, 29 (10), pp.1605-1621. ⟨10.1101/gr.249219.119⟩ Article dans une revue hal-02304180v2
The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is an independent prognostic marker in patients with malignant glioma Ana Xavier-Magalhães,Céline S Gonçalves,Tatiana Lourenço,Marta Pojo,Miguel Rochaet al. Oncotarget, 2018, 9 (21), pp.15740 - 15756. ⟨10.18632/oncotarget.24597⟩ Article dans une revue hal-01917288v1
DNA methylation profiling reveals a pathological signature that contributes to transcriptional defects of CD34 + CD15 − cells in early chronic-phase chronic myeloid leukemia Stéphanie Maupetit-Méhouas,Franck Court,Céline Bourgne,Agnès Guerci-Bresler,Pascale Cony-Makhoulet al. Molecular Oncology, 2018, 12 (6), pp.814 - 829. ⟨10.1002/1878-0261.12191⟩ Article dans une revue hal-01917284v1
An annotated list of bivalent chromatin regions in human ES cells: a new tool for cancer epigenetic research Franck Court,Philippe P. Arnaud Oncotarget, 2017, 8, pp.4110 - 4124 Article dans une revue hal-01917297v1
CLIFinder: Identification of LINE-1 Chimeric Transcripts in RNA-seq data Marie-Elisa Pinson,Romain Pogorelcnik,Franck Court,Philippe P. Arnaud,Catherine Vaurs-Barrière Bioinformatics, 2017, ⟨10.1093/bioinformatics/btx671⟩ Article dans une revue hal-01629422v1
Detection of the alternative lengthening of telomeres pathway in malignant gliomas for improved molecular diagnosis Anne Fogli,Marie-Véronique Demattei,Laetitia Corset,Catherine Vaurs-Barrière,E. Chautardet al. Journal of Neuro-Oncology, 2017, 135 (2), pp.381-390. ⟨10.1007/s11060-017-2585-7⟩ Article dans une revue hal-01643036v1
In Vitro Corticogenesis from Embryonic Stem Cells Recapitulates the In Vivo Epigenetic Control of Imprinted Gene Expression Tristan Bouschet,Emeric Dubois,Christelle Reynes,Satya Kota,Stéphanie Rialleet al. Cerebral Cortex, 2017, ⟨10.1093/cercor/bhw102⟩ Article dans une revue hal-01788685v1
The tumoral A genotype of the MGMT rs34180180 single-nucleotide polymorphism in aggressive gliomas is associated with shorter patients’ survival Anne Fogli,Emmanuel Chautard,Catherine Vaurs-Barrière,Bruno Pereira,Mélanie Müller-Barthélémyet al. Carcinogenesis, 2016, 37 (2), pp.169 - 176. ⟨10.1093/carcin/bgv251⟩ Article dans une revue hal-01629349v1
Imprinting control regions (ICRs) are marked by mono-allelic bivalent chromatin when transcriptionally inactive Stéphanie Maupetit-Méhouas,Bertille Montibus,David Nury,Chiharu Tayama,Michel M. Wassefet al. Nucleic Acids Research, 2016, 44 (2), pp.621 - 635. ⟨10.1093/nar/gkv960⟩ Article dans une revue hal-01917293v1
Deep sequencing and de novo assembly of the mouse oocyte transcriptome define the contribution of transcription to the DNA methylation landscape Lenka Veselovska,Sébastien Smallwood,Heba Saadeh,Kathleen R Stewart,Felix Kruegeret al. Genome Biology, 2015, 16, pp.209. ⟨10.1186/s13059-015-0769-z⟩ Article dans une revue hal-01917300v1
ICR Noncoding RNA Expression Controls Imprinting and DNA Replication at the Dlk1-Dio3 Domain Satya k. Kota,David Llères,Tristan Bouschet,Ryutaro Hirasawa,Alice Marchandet al. Developmental Cell, 2014, 31 (1), pp.19 - 33. ⟨10.1016/j.devcel.2014.08.009⟩ Article dans une revue hal-01788720v1
Transcription and histone methylation changes correlate with imprint acquisition in male germ cells Amandine Henckel,Karim Chebli,Satya Kota,Philippe P. Arnaud,Robert Feil EMBO Journal, 2012, 31 (3), pp.606 - 615. ⟨10.1038/emboj.2011.425⟩ Article dans une revue hal-01934523v1
Characterization of Novel Paternal ncRNAs at the Plagl1 Locus, Including Hymai, Predicted to Interact with Regulators of Active Chromatin Isabel Iglesias-Platas,Alex Martin-Trujillo,David Cirillo,Franck Court,Amy Guillaumet-Adkinset al. PLoS ONE, 2012, 7 (6), ⟨10.1371/journal.pone.0038907⟩ Article dans une revue hal-01934522v1
Synergic reprogramming of mammalian cells by combined exposure to mitotic Xenopus egg extracts and transcription factors Olivier Ganier,Stéphane S. Bocquet,Isabelle I. Peiffer,Vincent V. Brochard,Philippe P. Arnaudet al. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (42), pp.17331-17336. ⟨10.1073/pnas.1100733108⟩ Article dans une revue hal-01000287v1
Human imprinted retrogenes exhibit non-canonical imprint chromatin signatures and reside in non-imprinted host genes David Monk,Philippe P. Arnaud,Jennifer Frost,Andrew Wood,Michael Cowleyet al. Nucleic Acids Research, 2011, 39 (11), pp.4577 - 4586. ⟨10.1093/nar/gkq1230⟩ Article dans une revue hal-01934525v1
Genome-wide identification of new imprinted genes A. Henckel,Philippe P. Arnaud Briefings in Functional Genomics, 2010, 9 (4), pp.304--14. ⟨10.1093/bfgp/elq016⟩ Article dans une revue hal-02193464v1
Genomic imprinting in germ cells: imprints are under control Philippe P. Arnaud Reproduction [Cambridge], 2010, 140 (3), pp.411--23. ⟨10.1530/REP-10-0173⟩ Article dans une revue hal-02193452v1
Genome-wide identification of new imprinted genes A. Henckel,Philippe P. Arnaud Briefings in Functional Genomics and Proteomics, 2010, 9 (4), pp.304 - 314. ⟨10.1093/bfgp/elq016⟩ Article dans une revue hal-01934526v1
Genomic imprinting in germ cells: imprints are under control Philippe P. Arnaud Reproduction [Cambridge], 2010, 140 (3), pp.411 - 423. ⟨10.1530/REP-10-0173⟩ Article dans une revue hal-01934528v1
Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment O. Alder,F. Lavial,A. Helness,E. Brookes,S. Pinhoet al. Development (Cambridge, England), 2010, 137 (15), pp.2483--2492. ⟨10.1242/dev.048363⟩ Article dans une revue hal-02193451v1
Histone methylation is mechanistically linked to DNA methylation at imprinting control regions in mammals Amandine Henckel,Kazuhiko Nakabayashi,Lionel A. Sanz,Robert Feil,Kenichiro Hataet al. Human Molecular Genetics, 2009, 18 (18), pp.3375 - 3383. ⟨10.1093/hmg/ddp277⟩ Article dans une revue hal-01934530v1
Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression Philippe P. Arnaud,David Monk,Philip Arnaud,Jennifer Frost,Frank Hillset al. Human Molecular Genetics, 2009, 18 (16), pp.3066 - 3074. ⟨10.1093/hmg/ddp248⟩ Article dans une revue hal-01934533v1
Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing D. Monk,A. Wagschal,Philippe P. Arnaud,P. Muller,L. Parker-Katiraeeet al. Genome Research, 2008, 18 (8), pp.1270 - 1281. ⟨10.1101/gr.077115.108⟩ Article dans une revue hal-01934535v1
A mono-allelic bivalent chromatin domain controls tissue-specific imprinting at Grb10. Lionel A. Sanz,Stormy Chamberlain,Jean-Charles Sabourin,Amandine Henckel,Terry Magnusonet al. EMBO Journal, 2008, 27 (19), pp.2523-32. ⟨10.1038/emboj.2008.142⟩ Article dans une revue inserm-00349502v1
Chromatin Immunoprecipitation (ChIP) on Unfixed Chromatin from Cells and Tissues to Analyze Histone Modifications Alexandre Wagschal,Katia Delaval,Maëlle Pannetier,Philippe P. Arnaud,Robert Feil Cold Spring Harbor protocols, 2007, 2007 (12), pdb.prot4767 - pdb.prot4767. ⟨10.1101/pdb.prot4767⟩ Article dans une revue hal-01934545v1
Early mouse embryo development: could epigenetics influence cell fate determination? Amandine Henckel,Szabolcs Tóth,Philippe P. Arnaud BioEssays, 2007, 29 (6), pp.520 - 524. ⟨10.1002/bies.20591⟩ Article dans une revue istex hal-01934539v1
Identification of the Imprinted KLF14 Transcription Factor Undergoing Human-Specific Accelerated Evolution Layla Parker-Katiraee,Andrew R. Carson,Takahiro Yamada,Philippe P. Arnaud,Robert Feilet al. PLoS Genetics, 2007, 3 (5), pp.e65. ⟨10.1371/journal.pgen.0030065⟩ Article dans une revue hal-01934543v1
PCR-Based Analysis of Immunoprecipitated Chromatin Alexandre Wagschal,Katia Delaval,Maëlle Pannetier,Philippe P. Arnaud,Robert Feil Cold Spring Harbor protocols, 2007, 2007 (12), pdb.prot4768-pdb.prot4768. ⟨10.1101/pdb.prot4768⟩ Article dans une revue hal-02891751v1
Stochastic imprinting in the progeny of Dnmt3L−/− females Philippe P. Arnaud,Kenichiro Hata,Masahiro Kaneda,En Li,Hiroyuki Sasakiet al. Human Molecular Genetics, 2006, 15 (4), pp.589 - 598. ⟨10.1093/hmg/ddi475⟩ Article dans une revue hal-01934553v1
MEDEA Takes Control of Its Own Imprinting Philippe P. Arnaud,Robert Feil Cell, 2006, 124 (3), pp.468 - 470. ⟨10.1016/j.cell.2006.01.020⟩ Article dans une revue hal-01934551v1
Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human M Monk,S Sanches,Philippe P. Arnaud,A Apostolidou,H Hillset al. Human Molecular Genetics, 2006, 15 (8), pp.1259 - 1269. ⟨10.1093/hmg/ddl041⟩ Article dans une revue hal-01934550v1
Limited evolutionary conservation of imprinting in the human placenta R Monk,Philippe P. Arnaud,S. Apostolidou,F. Hills,G. Kelseyet al. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 (17), pp.6623 - 6628. ⟨10.1073/pnas.0511031103⟩ Article dans une revue hal-01934548v1
Epigenetic deregulation of genomic imprinting in human disorders and following assisted reproduction Philippe P. Arnaud,Robert Feil Birth Defects Research Part C: Embryo Today: Reviews, 2005, 75 (2), pp.81 - 97. ⟨10.1002/bdrc.20039⟩ Article dans une revue istex hal-01934555v1
Development of cyclodextrin microspheres for pulmonary drug delivery Malika Skiba,Frédéric Bounoure,Cécile Barbot,Philippe P. Arnaud,Mohamed Skiba Journal of Pharmacy and Pharmaceutical Sciences, 2005, 8 (3), pp.409-418 Article dans une revue hal-02279132v1
Identification and properties of imprinted genes and their control elements G Smith,Philippe P. Arnaud,G. Kelsey,R.J. Smith Cytogenetic and Genome Research, 2004, 105 (2-4), pp.335 - 345. ⟨10.1159/000078206⟩ Article dans une revue hal-01934557v1
Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus. Candice Coombes,Philippe P. Arnaud,Emma Gordon,Wendy Dean,Elizabeth Coaret al. Molecular and Cellular Biology, 2003, pp.5475-88. ⟨10.1128/MCB.23.16.5475-5488.2003⟩ Article dans une revue hal-01934561v1
Imprinted methylation profiles for proximal mouse Chromosomes 11 and 7 as revealed by methylation-sensitive representational difference analysis Philippe P. Arnaud,David Monk,Rachel Smith,Philip Arnaud,Michael Preeceet al. Mammalian Genome, 2003, 14 (12), pp.805 - 816. ⟨10.1007/s00335-003-2287-7⟩ Article dans une revue istex hal-01934559v1
Conserved methylation imprints in the human and mouse GRB10 genes with divergent allelic expression suggests differential reading of the same mark. Philippe P. Arnaud,Philip Arnaud,David Monk,Megan Hitchins,Emma Gordonet al. Human Molecular Genetics, 2003, pp.1005-19 Article dans une revue hal-01934563v1
The mouse Zac1 locus: basis for imprinting and comparison with human ZAC. Rachel Smith,Philippe P. Arnaud,Galia Konfortova,Wendy Dean,Colin Beecheyet al. Gene, 2002, pp.101-12 Article dans une revue hal-01934564v1
Analysis of the SINE S1 Pol III promoter from Brassica; impact of methylation and influence of external sequences. Philippe P. Arnaud,M Arnaud,Y Yukawa,L. Lavie,T Pélissieret al. The Plant Journal, 2001, pp.295-305 Article dans une revue hal-01934570v1
SINE Retroposons Can Be Used In Vivo as Nucleation Centers for De Novo Methylation Philippe P. Arnaud,Chantal Goubely,Thierry Pélissier,Jean-Marc Deragon Molecular and Cellular Biology, 2000, 20 (10), pp.3434-3441. ⟨10.1128/mcb.20.10.3434-3441.2000⟩ Article dans une revue hal-04821523v1
Improved thermostability of the North American firefly luciferase: saturation mutagenesis at position 354. J. White,J Squirrell,Philippe P. Arnaud,C Lowe,J Murray Biochemical Journal, 1996, pp.343-50 Article dans une revue hal-01934577v1