Philippe Bastin

Publications

Article dans une revue (58)

A novel approach to tagging tubulin reveals MT assembly dynamics of the axoneme in Trypanosoma brucei Daniel Abbühl,Martina Pružincová,Luděk Štěpánek,Eleonore Bouscasse,Rita Azevedoet al. Journal of Cell Science, 2025, 138 (20), pp.jcs.264145. ⟨10.1242/jcs.264145⟩ Article dans une revue pasteur-05101008v1
LRRC56 is an IFT cargo required for assembly of the distal dynein docking complex in Trypanosoma brucei Serge Bonnefoy,Aline Araujo Alves,Eloïse Bertiaux,Philippe Bastin Molecular Biology of the Cell, 2024, 35 (8), pp.ar106. ⟨10.1091/mbc.E23-11-0425)⟩ Article dans une revue pasteur-05099231v1
Spatial confinement of Trypanosoma brucei in microfluidic traps provides a new tool to study free swimming parasites Mariana de Niz,Emmanuel Frachon,Samy Gobaa,Philippe Bastin PLoS ONE, 2023, 18 (12), pp.e0296257. ⟨10.1371/journal.pone.0296257⟩ Article dans une revue pasteur-05114528v1
Restriction of intraflagellar transport to some microtubule doublets: An opportunity for cilia diversification? Adeline Mallet,Philippe Bastin BioEssays, 2022, pp.2200031. ⟨10.1002/bies.202200031⟩ Article dans une revue pasteur-03695743v1
The establishment of variant surface glycoprotein monoallelic expression revealed by single-cell RNA-seq of Trypanosoma brucei in the tsetse fly salivary glands Sebastian Hutchinson,Sophie Foulon,Aline Crouzols,Roberta Menafra,Brice Rotureauet al. PLoS Pathogens, 2021, 17 (9), pp.e1009904. ⟨10.1371/journal.ppat.1009904⟩ Article dans une revue pasteur-03661699v1
Redistribution of FLAgellar Member 8 during the trypanosome life cycle: Consequences for cell fate prediction Estefanía Calvo-Álvarez,Serge Bonnefoy,Audrey Salles,Fiona Benson,Paul Mckeanet al. Cellular Microbiology, 2021, pp.e13347. ⟨10.1111/cmi.13347⟩ Article dans une revue pasteur-03230881v1
Intraflagellar transport during assembly of flagella of different length in Trypanosoma brucei isolated from tsetse flies Eloïse Bertiaux,Adeline Mallet,Brice Rotureau,Philippe Bastin Journal of Cell Science, 2020, 133 (18), pp.jcs248989. ⟨10.1242/jcs.248989⟩ Article dans une revue pasteur-02970237v1
Timing and original features of flagellum assembly in trypanosomes during development in the tsetse fly Moara Lemos,Adeline Mallet,Eloise Bertiaux,Albane Imbert,Brice Rotureauet al. Parasites & Vectors, 2020, 13, pp.169. ⟨10.1186/s13071-020-04026-0⟩ Article dans une revue hal-02553740v1
IFT25 is required for the construction of the trypanosome flagellum Diego Huet,Thierry Blisnick,Sylvie Perrot,Philippe Bastin Journal of Cell Science, 2019, ⟨10.1242/jcs.228296⟩ Article dans une revue hal-03246254v1
Moteurs moléculaires et microtubules : relation libre, imposée ou sélective ? Adeline Mallet,Philippe Bastin Médecine/Sciences, 2019, 35 (4), pp.302-304. ⟨10.1051/medsci/2019062⟩ Article dans une revue hal-02984723v1
Biallelic Mutations in LRRC56, Encoding a Protein Associated with Intraflagellar Transport, Cause Mucociliary Clearance and Laterality Defects Serge Bonnefoy,Christopher M.Watson,Kristin Kernohan,Moara Lemos,Sebastian Hutchinsonet al. American Journal of Human Genetics, 2018, 103 (5), pp.727 - 739. ⟨10.1016/j.ajhg.2018.10.003⟩ Article dans une revue pasteur-01931456v1
A Grow-and-Lock Model for the Control of Flagellum Length in Trypanosomes Eloise Bertiaux,Benjamin Morga,Thierry Blisnick,Brice Rotureau,Philippe Bastin Current Biology, 2018, 28 (23), pp.3802-3814.e3. ⟨10.1016/j.cub.2018.10.031⟩ Article dans une revue pasteur-01928242v1
Flagellar incorporation of proteins follows at least two different routes in trypanosomes Laetitia Vincensini,Thierry Blisnick,Eloise Bertiaux,Sebastian Hutchinson,Christina Georgikouet al. Biology of the Cell, 2018, 110 (2), pp.33-47. ⟨10.1111/boc.201700052⟩ Article dans une revue pasteur-03112358v1
Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum Eloise Bertiaux,Adeline Mallet,Cécile Fort,Thierry Blisnick,Serge Bonnefoyet al. Journal of Cell Biology, 2018, ⟨10.1083/jcb.201805030⟩ Article dans une revue pasteur-01931458v1
STEM tomography analysis of the trypanosome transition zone Sylvain Trépout,Anne-Marie Tassin,Sergio Marco,Philippe Bastin Journal of Structural Biology, 2017, ⟨10.1016/j.jsb.2017.12.005⟩ Article dans une revue hal-02323498v1
Intraflagellar transport is required for the maintenance of the trypanosome flagellum composition but not its length. Cécile Fort,Serge Bonnefoy,Linda Kohl,Philippe Bastin Journal of Cell Science, 2016, 129 (15), pp.3026-41. ⟨10.1242/jcs.188227⟩ Article dans une revue pasteur-01351023v1
The more we know, the more we have to discover: an exciting future for understanding cilia and ciliopathies. Alexandre Benmerah,Bénédicte Durand,Rachel H Giles,Tess Harris,Linda Kohlet al. Cilia, 2015, 4 (1), pp.5. ⟨10.1186/s13630-015-0014-0⟩ Article dans une revue (article de synthèse) pasteur-01514418v1
Imaging intraflagellar transport in trypanosomes Julien Santi-Rocca,Nicolas Chenouard,Cécile Fort,Thibault Lagache,Jean-Christophe Olivo-Marinet al. Methods in Cell Biology, 2015, Methods in Cilia & Flagella, 127, pp.487-508. ⟨10.1016/bs.mcb.2015.01.005⟩ Article dans une revue pasteur-01301203v1
Social motility in African trypanosomes: fact or model? Philippe Bastin,Brice Rotureau Trends in Parasitology, 2015, 31 (2), pp.37-8. ⟨10.1016/j.pt.2014.12.007⟩ Article dans une revue pasteur-01301206v1
The Flagellar Arginine Kinase in Trypanosoma brucei Is Important for Infection in Tsetse Flies Cher-Pheng Ooi,Brice Rotureau,Simonetta Gribaldo,Christina Georgikou,Daria Julkowskaet al. PLoS ONE, 2015, 10 (7), pp. e0133676. ⟨10.1371/journal.pone.0133676⟩ Article dans une revue pasteur-01301205v1
IFT81, encoding an IFT-B core protein, as a very rare cause of a ciliopathy phenotype Isabelle Perrault,Jan Halbritter,Jonathan D. Porath,Xavier Gerard,Daniela A. Braunet al. Journal of Medical Genetics, 2015, 52 (10), pp.657-665. ⟨10.1136/jmedgenet-2014-102838⟩ Article dans une revue pasteur-01301204v1
Scanning transmission electron microscopy through-focal tilt-series on biological specimens Sylvain Trépout,Cédric Messaoudi,Sylvie Perrot,Philippe Bastin,Sergio Marco Micron, 2015, 77, pp.9-15. ⟨10.1016/j.micron.2015.05.015⟩ Article dans une revue pasteur-01301207v1
Flagellar membranes are rich in raft-forming phospholipids Mauro Serricchio,Adrien W. Schmid,Michael E. Steinmann,Erwin Sigel,Monika Rauchet al. Biology Open, 2015, 4 (9), pp.1143-1153. ⟨10.1242/bio.011957⟩ Article dans une revue pasteur-01301208v1
Proteomic Analysis of Intact Flagella of Procyclic Trypanosoma brucei Cells Identifies Novel Flagellar Proteins with Unique Sub-localization and Dynamics Ines Subota,Daria Julkowska,Laetitia Vincensini,Nele Reeg,Johanna Buissonet al. Molecular and Cellular Proteomics, 2014, 13 (7), pp.1769-1786. ⟨10.1074/mcp.M113.033357⟩ Article dans une revue pasteur-01301216v1
The GTPase IFT27 is involved in both anterograde and retrograde intraflagellar transport. Diego Huet,Thierry Blisnick,Sylvie Perrot,Philippe Bastin eLife, 2014, 3, pp.e02419. ⟨10.7554/eLife.02419⟩ Article dans une revue pasteur-01301212v1
The intraflagellar transport dynein complex of trypanosomes is made of a heterodimer of dynein heavy chains and of light and intermediate chains of distinct functions Thierry Blisnick,Johanna Buisson,Sabrina Absalon,Alexandra Marie,Nadège Cayetet al. Molecular Biology of the Cell, 2014, 25 (17), pp.2620-2633. ⟨10.1091/mbc.E14-05-0961⟩ Article dans une revue pasteur-01301215v1
Elongation of the axoneme and dynamics of intraflagellar transport Cécile Fort,Philippe Bastin Médecine/Sciences, 2014, 30 (11), pp.955-961. ⟨10.1051/medsci/20143011008⟩ Article dans une revue pasteur-01301213v1
Generation of a Nanobody Targeting the Paraflagellar Rod Protein of Trypanosomes Emmanuel Obishakin,Benoit Stijlemans,Julien Santi-Rocca,Isabel Vandenberghe,Bart Devreeseet al. PLoS ONE, 2014, 9 (12), pp.e115893. ⟨10.1371/journal.pone.0115893⟩ Article dans une revue pasteur-01301214v1
Flagellar adhesion in Trypanosoma brucei relies on interactions between different skeletal structures in the flagellum and cell body Brice Rotureau,Thierry Blisnick,Ines Subota,Daria Julkowska,Nadège Cayetet al. Journal of Cell Science, 2014, 127 (1), pp.204-215. ⟨10.1242/jcs.136424⟩ Article dans une revue pasteur-01301211v1
The Leishmania donovani chaperone cyclophilin 40 is essential for intracellular infection independent of its stage-specific phosphorylation status. Wai-Lok Yau,Pascale Pescher,Andrea Macdonald,Sonia Hem,Dorothea Zanderet al. Molecular Microbiology, 2014, 93 (1), pp.80-97. ⟨10.1111/mmi.12639⟩ Article dans une revue hal-01054664v1
Forward motility is essential for trypanosome infection in the tsetse fly Brice Rotureau,Cher-Pheng Ooi,Diego Huet,Sylvie Perrot,Philippe Bastin Cellular Microbiology, 2014, 16 (3), pp.425-433. ⟨10.1111/cmi.12230⟩ Article dans une revue pasteur-01301209v1
Boarder control on the IFT train. Cécile Fort,Philippe Bastin eLife, 2014, 3, pp.e02531. ⟨10.7554/eLife.02531⟩ Article dans une revue pasteur-01301210v1
Getting to the heart of intraflagellar transport using Trypanosoma and Chlamydomonas models: the strength is in their differences. Benjamin Morga,Philippe Bastin Cilia, 2013, 2 (1), pp.16. ⟨10.1186/2046-2530-2-16⟩ Article dans une revue pasteur-00911797v1
Intraflagellar transport proteins cycle between the flagellum and its base Johanna Buisson,Nicolas Chenouard,Thibault Lagache,Thierry Blisnick,Jean-Christophe Olivo-Marinet al. Journal of Cell Science, 2013, 126 (1), pp.327-338. ⟨10.1242/jcs.117069⟩ Article dans une revue hal-03246304v1
Apoptotic marker expression in the absence of cell death in staurosporine-treated Leishmania donovani Aude L. Foucher,Najma Rachidi,Sarah Gharbi,Thierry Blisnick,Philippe Bastinet al. Antimicrobial Agents and Chemotherapy, 2013, 57 (3), pp.1252-1261. ⟨10.1128/AAC.01983-12⟩ Article dans une revue pasteur-01433417v1
Molecular Basis of Tubulin Transport Within the Cilium by IFT74 and IFT81 Sagar Bhogaraju,Lukas Cajanek,Cécile Fort,Thierry Blisnick,Kristina Weberet al. Science, 2013, 341 (6149), pp.1009-1012. ⟨10.1126/science.1240985⟩ Article dans une revue hal-03246299v1
Trypanosoma brucei FKBP12 differentially controls motility and cytokinesis in procyclic and bloodstream forms. Anaïs Brasseur,Brice Rotureau,Marjorie Vermeersch,Thierry Blisnick,Didier Salmonet al. Eukaryotic Cell, 2013, 12 (2), pp.168-81. ⟨10.1128/EC.00077-12⟩ Article dans une revue pasteur-01371316v1
A new asymmetric division contributes to the continuous production of infective trypanosomes in the tsetse fly. Brice Rotureau,Ines Subota,Johanna Buisson,Philippe Bastin Development (Cambridge, England), 2012, 139 (10), pp.1842-50. ⟨10.1242/dev.072611⟩ Article dans une revue pasteur-01371317v1
The importance of model organisms to study cilia and flagella biology Laetitia Vincensini,Thierry Blisnick,Philippe Bastin Biologie Aujourd'hui, 2011, 205 (1), pp.5-28. ⟨10.1051/jbio/2011005⟩ Article dans une revue istex hal-03246292v1
Molecular bases of cytoskeleton plasticity during the Trypanosoma brucei parasite cycle. Brice Rotureau,Ines Subota,Philippe Bastin Cellular Microbiology, 2011, 13 (5), pp.705-16. ⟨10.1111/j.1462-5822.2010.01566.x⟩ Article dans une revue pasteur-01371324v1
1001 model organisms to study cilia and flagella Laetitia Vincensini,Thierry Blisnick,Philippe Bastin Biology of the Cell, 2011, 103 (3), pp.109-130. ⟨10.1042/BC20100104⟩ Article dans une revue hal-03246287v1
The ciliary pocket: a once-forgotten membrane domain at the base of cilia Rania Ghossoub,Anahi Mollà-Herman,Philippe Bastin,Alexandre Benmerah Biology of the Cell, 2011, 103 (3), pp.131-144. ⟨10.1042/BC20100128⟩ Article dans une revue (article de synthèse) inserm-02263813v1
ALBA proteins are stage regulated during trypanosome development in the tsetse fly and participate in differentiation. Ines Subota,Brice Rotureau,Thierry Blisnick,Sandra Ngwabyt,Mickaël Durand-Dubiefet al. Molecular Biology of the Cell, 2011, 22 (22), pp.4205-19. ⟨10.1091/mbc.E11-06-0511)⟩ Article dans une revue pasteur-01371322v1
Quantitative proteome profiling informs on phenotypic traits that adapt Leishmania donovani for axenic and intracellular proliferation Pascale Pescher,Thierry Blisnick,Philippe Bastin,Gerald F Späth Cellular Microbiology, 2011, 13 (7), pp.978-991. ⟨10.1111/j.1462-5822.2011.01593.x⟩ Article dans une revue pasteur-01433560v1
Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability Wai-Lok Yau,Thierry Blisnick,Jean-François Taly,Manuela Helmer-Citterich,Cordelia Schiene-Fischeret al. PLoS Neglected Tropical Diseases, 2010, 4 (6), pp.e729. ⟨10.1371/journal.pntd.0000729⟩ Article dans une revue pasteur-01433566v1
The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia Anahi Mollà-Herman,Rania Ghossoub,Thierry Blisnick,Alice Meunier,Catherine Serreset al. Journal of Cell Science, 2010, 123 (10), pp.1785-1795. ⟨10.1242/jcs.059519⟩ Article dans une revue hal-02353018v1
Loss-of-Function Mutations in the Human Ortholog of Chlamydomonas reinhardtii ODA7 Disrupt Dynein Arm Assembly and Cause Primary Ciliary Dyskinesia Philippe Duquesnoy,Estelle Escudier,Laetitia Vincensini,Judy Freshour,Anne-Marie Bridouxet al. American Journal of Human Genetics, 2009, 85 (6), pp.890-896. ⟨10.1016/j.ajhg.2009.11.008⟩ Article dans une revue inserm-03894697v1
The flagellum-mitogen-activated protein kinase connection in Trypanosomatids: a key sensory role in parasite signalling and development? Brice Rotureau,Miguel Morales,Philippe Bastin,Gerald F Späth Cellular Microbiology, 2009, 11 (5), pp.710 - 718. ⟨10.1111/j.1462-5822.2009.01295.x⟩ Article dans une revue pasteur-01849836v1
A novel function for the atypical small G protein Rab-like 5 in the assembly of the trypanosome flagellum Christine Adhiambo,Thierry Blisnick,Géraldine Toutirais,Emmanuelle Delannoy,Philippe Bastin Journal of Cell Science, 2009, 122 (6), pp.834-841. ⟨10.1242/jcs.040444⟩ Article dans une revue hal-03246322v1
Kinesin 9 family members perform separate functions in the trypanosome flagellum Raphaël Demonchy,Thierry Blisnick,Caroline Deprez,Geraldine Toutirais,Celine Loussertet al. Journal of Cell Biology, 2009, 187 (5), pp.615-622. ⟨10.1083/jcb.200903139⟩ Article dans une revue mnhn-02047425v1
Intraflagellar Transport and Functional Analysis of Genes Required for Flagellum Formation in Trypanosomes. Sabrina Absalon,Thierry Blisnick,Linda Kohl,Géraldine Toutirais,Gwénola Doréet al. Molecular Biology of the Cell, 2008, 19 (3), pp.929-944. ⟨10.1091/mbc.E07-08-0749⟩ Article dans une revue pasteur-00217549v1
Flagellum elongation is required for correct structure, orientation and function of the flagellar pocket in Trypanosoma brucei. Sabrina Absalon,Thierry Blisnick,Mélanie Bonhivers,Linda Kohl,Nadège Cayetet al. Journal of Cell Science, 2008, 121 (Pt 22), pp.3704-16. ⟨10.1242/jcs.035626⟩ Article dans une revue hal-00426339v1
Basal body positioning is controlled by flagellum formation in Trypanosoma brucei. Sabrina Absalon,Linda Kohl,Carole Branche,Thierry Blisnick,Géraldine Toutiraiset al. PLoS ONE, 2007, 2, pp.e437. ⟨10.1371/journal.pone.0000437⟩ Article dans une revue pasteur-00169134v1
Conserved and specific functions of axoneme components in trypanosome motility. Carole Branche,Linda Kohl,Géraldine Toutirais,Johanna Buisson,Jacky Cossonet al. Journal of Cell Science, 2006, 119 (Pt 16), pp.3443-55. ⟨10.1242/jcs.03078⟩ Article dans une revue hal-00108209v1
Functional complementation of RNA interference mutants in trypanosomes. Filippo Rusconi,Mickaël Durand-Dubief,Philippe Bastin BMC Biotechnology, 2005, 5, pp.6. ⟨10.1186/1472-6750-5-6⟩ Article dans une revue inserm-00093264v1
The flagellum of trypanosomes. Linda Kohl,Philippe Bastin Int Rev Cytol, 2005, 244, pp.227-85. ⟨10.1016/S0074-7696(05)44006-1⟩ Article dans une revue hal-00109408v1
TbAGO1, an argonaute protein required for RNA interference, is involved in mitosis and chromosome segregation in Trypanosoma brucei. Mickaël Durand-Dubief,Philippe Bastin BMC Biology, 2003, 1, pp.2. ⟨10.1186/1741-7007-1-2⟩ Article dans une revue hal-00108479v1
Novel roles for the flagellum in cell morphogenesis and cytokinesis of trypanosomes. Linda Kohl,Derrick Robinson,Philippe Bastin EMBO Journal, 2003, 22 (20), pp.5336-46. ⟨10.1093/emboj/cdg518⟩ Article dans une revue hal-00108210v1

Communication dans un congrès (2)

Using steerable wavelets and minimal paths to reconstruct automatically filaments in fluorescence imaging Thibault Lagache,Quentin Marcou,Antoine Bardonnet,Brice Rotureau,Philippe Bastinet al. 2015 IEEE International Conference on Image Processing (ICIP), Sep 2015, Quebec City, France. pp.706-709, ⟨10.1109/ICIP.2015.7350890⟩ Communication dans un congrès hal-05290186v1
Alteration of nephrocystins and IFT-A proteins causes similar ciliary phenotypes leading to Nephronophthisis Sophie Saunier,Albane A. Bizet,Flora Silbermann,Emilie Filhol,Thierry Blisnicket al. First International Cilia in Development and Disease Scientific Conference, May 2012, London, United Kingdom. pp.P99, ⟨10.1186/2046-2530-1-S1-P99⟩ Communication dans un congrès inserm-00752970v1

Poster de conférence (3)

Resolving 3D structure of host pathogen interactions and pathogens ultrastructure from FIB SEM images with data analysis software Manuel Majrouh,Esthel Pénard,Nadège Cayet,Perrine Bomme,Dorian Obinoet al. Focus On Microscopy 2023, Apr 2023, Porto (Portugal), France Poster de conférence pasteur-05420889v1
The role of G proteins in the control of intraflagellar transport Diego Huet,Sylvie Perrot,Thierry Blisnick,Philippe Bastin First International Cilia in Development and Disease Scientific Conference, May 2012, Londres, United Kingdom. , 1 (Suppl 1), pp.P24, 2012 Poster de conférence pasteur-00752960v1
Sub-localisation of novel proteins with unique dynamics during assembly and maintenance of the eukaryotic flagellum Philippe Bastin,D Julkowska,I Subota,L Vincensini,Thierry Blisnicket al. First International Cilia in Development and Disease Scientific Conference, May 2012, London, United Kingdom. Cilia, 1 (Suppl 1), pp.P13, 2012, ⟨10.1186/2046-2530-1-S1-P13⟩ Poster de conférence pasteur-00752957v1

Chapitre d'ouvrage (1)

Progress in Research on African Trypanosomes: Highlights from an Exceptional Decade Sebastian Hutchinson,Estefania Calvo-Alvarez,Jean Marc Tsagmo,Moara Lemos,Christelle Travailléet al. Lifecycles of Pathogenic Protists in Humans, 35, Springer International Publishing, pp.99-142, 2022, Microbiology Monographs, 978-3-030-80682-8. ⟨10.1007/978-3-030-80682-8_2⟩ Chapitre d'ouvrage pasteur-03695260v1

Pré-publication, Document de travail (1)

The ANKS3/BICC1 protein complex is a master post-transcriptional regulator of NPHP1 ciliopathy-gene transcripts Alexia Mahuzier,Gweltas Odye,Valentina Grampa,Albane Bizet,Amandine Viauet al. 2024 Pré-publication, Document de travail hal-04986015v1