Philippe Bertolino

Publications

Article dans une revue (38)

Mast cells act as pro-angiogenic and pro-tumorigenic players in pituitary gonadotroph tumors Mirela-Diana Ilie,Álvaro Flores-Martínez,Marie Chanal,Maxime Lepetit,Benoit Samsonet al. Neuro-Oncology, 2025, ⟨10.1093/neuonc/noaf241⟩ Article dans une revue hal-05328726v1
The Proinflammatory Secretome of Senescent Cells Can Be Controlled by a HIF2A ‐Dependent Upregulation and a FURIN ‐Dependent Cleavage of the ANGPTL4 Secreted Factor Gabriela Makulyte,Hasan Safwan‐zaiter,Delphine Goehrig,Anda Huna,Adèle Mangelincket al. Aging Cell, 2025, ⟨10.1111/acel.70307⟩ Article dans une revue hal-05432091v1
A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism Khaled Tighanimine,José Américo Nabuco Leva Ferreira Freitas,Ivan Nemazanyy,Alexia Bankolé,Delphine Benarroch-Popivkeret al. Nature Metabolism, 2024, 6 (2), pp.323-342. ⟨10.1038/s42255-023-00972-y⟩ Article dans une revue hal-04511215v1
A non-canonical role of ELN protects from cellular senescence by limiting iron-dependent regulation of gene expression Joanna Czarnecka-Herok,Kexin Zhu,Jean-Michel Flaman,Delphine Goehrig,Mathieu Vernieret al. Redox Biology, 2024, 73, pp.103204. ⟨10.1016/j.redox.2024.103204⟩ Article dans une revue hal-04631521v1
Soft extracellular matrix drives endoplasmic reticulum stress-dependent S quiescence underlying molecular traits of pulmonary basal cells Pierre-Alexandre Laval,Marie Piecyk,Paul Le Guen,Mirela-Diana Ilie,Aubepart Marionet al. Acta Biomaterialia, 2024, 182, pp.93-110. ⟨10.1016/j.actbio.2024.05.033⟩ Article dans une revue hal-04733367v2
Stiffness-induced cancer-associated fibroblasts are responsible for immunosuppression in a platelet-derived growth factor ligand-dependent manner Pia Gamradt,Kevin Thierry,Melissa Masmoudi,Zhichong Wu,Hector Hernandez-Vargaset al. PNAS Nexus, 2023, 2 (12), ⟨10.1093/pnasnexus/pgad405⟩ Article dans une revue hal-04373776v1
Inhibition of activin signalling reduces the growth of LβT2 gonadotroph pituitary tumours in mouse Audrey Ziverec,Marie Chanal,Perrine Raymond,Mirela Diana Ilie,Dario de Alcubierreet al. Endocrine-Related Cancer, 2023, 30 (3), ⟨10.1530/ERC-22-0245⟩ Article dans une revue hal-04115686v1
Pericyte stem cells induce &lt;scp&gt;Ly6G&lt;/scp&gt; &lt;sup&gt;+&lt;/sup&gt; cell accumulation and immunotherapy resistance in pancreatic cancer Zhichong Wu,Kevin Thierry,Sophie Bachy,Xinyi Zhang,Pia Gamradtet al. EMBO Reports, 2023, ⟨10.15252/embr.202256524⟩ Article dans une revue hal-04047023v1
Biological and Therapeutic Implications of the Tumor Microenvironment in Pituitary Adenomas Mirela-Diana Ilie,Alexandre Vasiljevic,Philippe Bertolino,Gérald Raverot Endocrine reviews, 2023, 44 (2), pp.297-311. ⟨10.1210/endrev/bnac024⟩ Article dans une revue hal-04113463v1
Loss of Pla2r1 decreases cellular senescence and age‐related alterations caused by aging and Western diets Amélie Massemin,Delphine Goehrig,Jean‐michel Flaman,Sara Jaber,Audrey Griveauet al. Aging Cell, 2023, ⟨10.1111/acel.13971⟩ Article dans une revue hal-04225404v1
scAN1.0: A reproducible and standardized pipeline for processing 10X single cell RNAseq data Maxime Lepetit,Mirela Diana Ilie,Marie Chanal,Gérald Raverot,Philippe Bertolinoet al. In Silico Biology, 2023, 15, pp.11 - 21. ⟨10.3233/isb-220252⟩ Article dans une revue hal-04305326v1
Intratumoural spatial distribution of S100B + folliculostellate cells is associated with proliferation and expression of FSH and ERα in gonadotroph tumours Mirela Diana Ilie,Alexandre Vasiljevic,Marie Chanal,Nicolas Gadot,Laura Chinezuet al. Acta Neuropathologica Communications, 2022, 10 (1), pp.18. ⟨10.1186/s40478-022-01321-y⟩ Article dans une revue hal-03666692v1
Exploring the MEN1 dependent modulation of caspase 8 and caspase 3 in human pancreatic and murine embryo fibroblast cells Nele Wagener,Malte Buchholz,Philippe Bertolino,Chang Zhang,Pietro Di Fazio Apoptosis, 2022, 27 (1-2), pp.70-79. ⟨10.1007/s10495-021-01700-1⟩ Article dans une revue hal-03666683v1
Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration Michèle Mg Hillege,Andi Shi,Ricardo Galli,Gang Wu,Philippe Bertolinoet al. eLife, 2022, 11, ⟨10.7554/eLife.77610⟩ Article dans une revue hal-03766456v1
EGFR-dependent aerotaxis is a common trait of breast tumour cells Ivan Mikaelian,Rudy Gadet,Mathieu Deygas,Philippe Bertolino,Ana Henninoet al. Journal of experimental & clinical cancer research, 2022, 41 (1), pp.324. ⟨10.1186/s13046-022-02514-y⟩ Article dans une revue hal-04045454v1
The scaffold protein menin is essential for activating the MYC locus and MYC‐mediated androgen receptor transcription in androgen receptor‐dependent prostate cancer cells Yakun Luo,Virginie Vlaeminck‐guillem,Romain Teinturier,Razan Abou Ziki,Philippe Bertolinoet al. Cancer Communications, 2021, 41 (12), pp.1427-1430. ⟨10.1002/cac2.12217⟩ Article dans une revue hal-03666677v1
Phospholipase A2 receptor 1 promotes lung cell senescence and emphysema in obstructive lung disease Delphine Beaulieu,Aya Attwe,Marielle Breau,Larissa Lipskaia,Elisabeth Marcoset al. European Respiratory Journal, 2021, 58 (2), pp.2000752. ⟨10.1183/13993003.00752-2020⟩ Article dans une revue inserm-03420591v1
Men1 disruption in Nkx3.1-deficient mice results in ARlow/CD44+ microinvasive carcinoma development with the dysregulated AR pathway Romain Teinturier,Yakun Luo,Myriam Decaussin-Petrucci,Virginie Vlaeminck-Guillem,Francis Vacherotet al. Oncogene, 2021, 40 (6), pp.1118-1127. ⟨10.1038/s41388-020-01589-1⟩ Article dans une revue hal-03666659v1
PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging Anda Huna,Audrey Griveau,David Vindrieux,Sara Jaber,Jean-Michel Flamanet al. Cell Death and Disease, 2021, 12 (2), pp.190. ⟨10.1038/s41419-021-03468-3⟩ Article dans une revue inserm-03420490v1
Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation Christos Karampelias,Habib Rezanejad,Mandy Rosko,Likun Duan,Jing Luet al. Nature Communications, 2021, 12 (1), pp.3362. ⟨10.1038/s41467-021-23673-0⟩ Article dans une revue hal-03666669v1
Reduced menin expression leads to decreased ERα expression and is correlated with the occurrence of human luminal B-like and ER-negative breast cancer subtypes Romain Teinturier,Razan Abou Ziki,Loay Kassem,Yakun Luo,Lucie Malbeteauet al. Breast Cancer Research and Treatment, 2021, 190 (3), pp.389-401. ⟨10.1007/s10549-021-06339-9⟩ Article dans une revue hal-03666672v1
Stroma Involvement in Pancreatic Ductal Adenocarcinoma: An Overview Focusing on Extracellular Matrix Proteins Sophie Liot,Jonathan Balas,Alexandre Aubert,Laura Prigent,Perrine Mercier-Gouyet al. Frontiers in Immunology, 2021, 12, ⟨10.3389/fimmu.2021.612271⟩ Article dans une revue hal-03281971v1
Oncogene-Induced Senescence Limits the Progression of Pancreatic Neoplasia through Production of Activin A Yajie Zhao,Zhichong Wu,Marie Chanal,Fabienne Guillaumond,Delphine Goehriget al. Cancer Research, 2020, 80 (16), pp.3359-3371. ⟨10.1158/0008-5472.CAN-19-3763⟩ Article dans une revue hal-03008999v1
Chromosomal instability in the prediction of pituitary neuroendocrine tumors prognosis Hélène Lasolle,Mad-Hélénie Elsensohn,Anne Wierinckx,Eudeline Alix,Clément Bonnefilleet al. Acta Neuropathologica Communications, 2020, 8 (1), pp.190. ⟨10.1186/s40478-020-01067-5⟩ Article dans une revue hal-04383012v1
Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness Kevin Berthenet,Camila Castillo Ferrer,Deborah Fanfone,Nikolay Popgeorgiev,David Neveset al. Cell Reports, 2020, 31 (10), pp.107731. ⟨10.1016/j.celrep.2020.107731⟩ Article dans une revue hal-02999426v1
Generation of a conditional transgenic mouse model expressing human Phospholipase A2 Receptor 1 Sara Jaber,Delphine Goehrig,Philippe Bertolino,Amélie Massemin,Franck Bihlet al. Scientific Reports, 2020, 10 (1), pp.8190. ⟨10.1038/s41598-020-64863-y⟩ Article dans une revue inserm-02865473v1
Immune Landscape of Pituitary Tumors Reveals Association Between Macrophages and Gonadotroph Tumor Invasion Moitza Principe,Marie Chanal,Mirela Diana Ilie,Audrey Ziverec,Alexandre Vasiljevicet al. Journal of Clinical Endocrinology and Metabolism, 2020, 105 (11), pp.3459-3473. ⟨10.1210/clinem/dgaa520⟩ Article dans une revue hal-03666638v1
Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer Delphine Goehrig,Jérémy Nigri,Rémi Samain,Zhichong Wu,Paola Cappelloet al. Gut, 2019, 68 (4), pp.693-707. ⟨10.1136/gutjnl-2018-317570⟩ Article dans une revue hal-02526963v1
The Microenvironment of Pituitary Tumors—Biological and Therapeutic Implications Mirela Diana Ilie,Alexandre Vasiljevic,Gérald Raverot,Philippe Bertolino Cancers, 2019, 11 (10), pp.1605. ⟨10.3390/cancers11101605⟩ Article dans une revue hal-03666599v1
Phospholipase D regulates the size of skeletal muscle cells through the activation of mTOR signaling. Rami Jaafar,Joffrey de Larichaudy,Stéphanie Chanon,Vanessa Euthine,Christine Durandet al. Cell Communication and Signaling, 2013, 11 (1), pp.55. ⟨10.1186/1478-811X-11-55⟩ Article dans une revue inserm-00868745v1
Assignment testing reveals multiple introduced source populations including potential ash hybrids (Fraxinus excelsior x F. angustifolia) in Ireland M. Thomasset,Jf. Fernandez-Manjarres,G.C Douglas,P. Bertolino,Nathalie Frascaria-Lacosteet al. European Journal of Forest Research, 2013, 132, pp.195-209 Article dans une revue hal-01569267v1
Reexpression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse. J. Lu,Z. Hamze,R. Bonnavion,N. Herath,C. Pouponnotet al. Oncogene, 2012, 31 (31), pp.3647-54. ⟨10.1038/onc.2011.538⟩ Article dans une revue hal-00723094v1
Tif1γ Suppresses Murine Pancreatic Tumoral Transformation by a Smad4-Independent Pathway David Vincent,Johann Gout,Nicolas Chuvin,Vanessa Arfi,Roxane M. Pommieret al. American Journal of Pathology, 2012, 180 (6), pp.2214-2221. ⟨10.1016/j.ajpath.2012.02.006⟩ Article dans une revue hal-02954464v1
Reconstituted expression of menin in Men1-deficient mouse Leydig tumour cells induces cell cycle arrest and apoptosis Nader Hussein,Huguette Casse,Sandra Fontanière,Anne-Marie Morera,Marie Asensioet al. European Journal of Cancer, 2007, 43 (2), pp.402-414 Article dans une revue hal-02659050v1
Death by neglec as a deletional machanism of peripheral tolerance. P. Bertolino,Trescol-Biemont M.C.,J. Thomas,Fazekas de St Groth B.,M. Philgrenet al. International Immunology, 1999, 11, pp.1225-1238 Article dans une revue hal-00144472v1
Deletion of a C-terminal sequence of the class II-associated invariant chain abrogates invariant chains oligomer formation and class II antigen presentation. P. Bertolino,M Staschewski,M Trescol-Biémont,I Freisewinkel,K Schencket al. Journal of Immunology, 1995, 154 (11), pp.5620-9 Article dans une revue hal-02475206v1
Invariant Chain Expression Similarly Controls Presentation of Endogenously Synthesized and Exogenous Antigens by MHC Class II Molecules S. Lombard-Platet,P. Bertolino,C. Gimenez,M. Humbert,D. Gerlieret al. Cellular Immunology, 1993, 148 (1), pp.60-70. ⟨10.1006/cimm.1993.1091⟩ Article dans une revue istex hal-02475535v1
Inhibition by chloroquine of the class II major histocompatibility complex-restricted presentation of endogenous antigens varies according to the cellular origin of the antigen-presenting cells, the nature of the T-cell epitope, and the responding T cell. S Lombard-Platlet,P. Bertolino,H. Deng,D. Gerlier Immunology, 1993, 80 (4), pp.566-73 Article dans une revue hal-02475532v1

Logiciel (1)

scan10 : Nextflow pipeline for pre-processing and preliminary analysis of single cell RNA-seq data Maxime Lepetit,Laurent Modolo,Franck Picard,Philippe Bertolino 2023, ⟨swh:1:dir:c29f3adcd2cc47cd87dd7f158263bb4d72d101e1;origin=https://gitbio.ens-lyon.fr/LBMC/sbdm/scan10/;visit=swh:1:snp:c9664cb77fa2b68ce8ec656b4fca2cb6dd6b7e82;anchor=swh:1:rev:9b8ee5962601319e3c753d8ee59c231c94a484b6⟩ Logiciel hal-04911084v1

Poster de conférence (2)

Soft matrix maintains the molecular traits of pulmonary basal cells Pierre-Alexandre Laval,Marie Piecyk,Paul Le Guen,Mirela-Diana Ilie,Joelle Fauvreet al. Journée collaborative Lyon Biopole, Oct 2023, GRENOBLE, France Poster de conférence hal-04585211v1
Exploring the transcriptional landscape of gonadotroph tumor microenvironment with single cell RNA-seq Benoît Aliaga,Julie Ripoll,Marie Chanal,Hector Hernandez-Vargas,Emmanuel Jouanneauet al. SFBI. JOBIM 2021 - 21es Journées Ouvertes en Biologie, Informatique et Mathématiques, Jul 2021, Paris, France. , 2021 Poster de conférence lirmm-03544671v1