philippe de Medina Chercheur

Publications

Article dans une revue (47)

Selective DHCR7 inhibition versus AEBS modulation: Mechanistic implications for tamoxifen effects in AML Marc Poirot,Philippe de Medina,Sandrine Silvente‐poirot British Journal of Haematology, 2026, Online ahead of print. ⟨10.1111/bjh.70420⟩ Article dans une revue inserm-05553796v1
The Phospholipid Bis(monoacylglycero)Phosphate Confers Antitumour Immunogenicity to Exosomes Secreted by Dendrogenin A, Which Activates Its Biosynthesis in Tumour Cells Julio Buñay,Michel Record,Philippe de Medina,Silia Ayadi,Laly Pucheuet al. Journal of Extracellular Vesicles, 2026, 15 (2), pp.e70225. ⟨10.1002/jev2.70225⟩ Article dans une revue inserm-05495718v1
Oxysterols at the Crossroads of Cholesterol Metabolism and Cancer Julio Buñay,Silia Ayadi,Chloe Gressein,Philippe de Medina,Sandrine Silvente-Poirotet al. Seminars in Cancer Biology, 2026, Online ahead of print. ⟨10.1016/j.semcancer.2026.03.001⟩ Article dans une revue inserm-05553790v1
Liver X receptors and the hallmarks of aging: From molecular mechanisms to therapeutic opportunities Marc Poirot,Julio Buñay,Silia Ayadi,Sandrine Silvente-Poirot,Philippe de Medina Ageing Research Reviews - ARR, 2026, 114, pp.102967. ⟨10.1016/j.arr.2025.102967⟩ Article dans une revue inserm-05394944v1
Chemical synthesis and biochemical properties of cholestane-5α,6β-diol-3-sulfonate: A non-hydrolysable analogue of cholestane-5α,6β-diol-3β-sulfate Philippe de Medina,Silia Ayadi,Régis Soulès,Bruno Payre,Sandrine Rup-Jacqueset al. Journal of Steroid Biochemistry and Molecular Biology, 2023, 234, pp.106396. ⟨10.1016/j.jsbmb.2023.106396⟩ Article dans une revue hal-04509731v1
27-hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor Silia Ayadi,Silvia Friedrichs,Regis Soulès,Laly Pucheu,Dieter Lütjohannet al. Journal of Lipid Research, In press, 64 (12), pp.100479. ⟨10.1016/j.jlr.2023.100479⟩ Article dans une revue inserm-04317313v1
Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome‐enriched vesicles Michel Record,Mehdi Attia,Kevin Carayon,Laly Pucheu,Julio Bunayet al. Journal of Extracellular Vesicles, 2022, 11 (4), pp.e12211. ⟨10.1002/jev2.12211⟩ Article dans une revue inserm-03649213v1
Targeting NR1H/liver X receptor with dendrogenin A differentiates tumor cells to activate a new secretory pathway releasing immunogenic anti-tumor vesicles enriched in LC3-II-associated exosomes Philippe de Medina,Julio Bunay,Marc Poirot,Michel Record,Sandrine Silvente-Poirot Autophagy, 2022, 19 (3), pp.1036-1038. ⟨10.1080/15548627.2022.2116175⟩ Article dans une revue inserm-03854248v1
Oxysterols are potential physiological regulators of ageing Philippe de Medina,Sandrine Silvente-Poirot,Marc Poirot Ageing Research Reviews - ARR, 2022, 77, pp.101615. ⟨10.1016/j.arr.2022.101615⟩ Article dans une revue inserm-03629546v1
The 5,6-epoxycholesterol metabolic pathway in cancer: emergence of new pharmacological targets Philippe de Médina,Khadijetou Diallo,Emilie Huc Claustre,Mehdi Attia,Régis Soulèset al. British Journal of Pharmacology, 2020, 178 (16), pp.3248-3260. ⟨10.22541/au.159069407.75369904⟩ Article dans une revue inserm-03086999v1
Dendrogenin A Enhances Anti-Leukemic Effect of Anthracycline in Acute Myeloid Leukemia Pierre-Luc Mouchel,Nizar Serhan,Rémy Bétous,Thomas Farge,Estelle Salandet al. Cancers, 2020, 12 (10), pp.2933. ⟨10.3390/cancers12102933⟩ Article dans une revue inserm-03084630v1
Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo Nizar Serhan,Pierre-Luc Mouchel,Philippe de Médina,Gregory Segala,Aurélie Mougelet al. Cancers, 2020, 12 (7), pp.1725. ⟨10.3390/cancers12071725⟩ Article dans une revue inserm-03084638v1
HPLC Analysis and Skin Whitening Effects of Umbelliprenin-containing Extracts of Anethum Graveolens, Pimpinella Anisum, and Ferulago Campestris Vito Taddeo,Francesco Epifano,Francesca Preziuso,Serena Fiorito,Nicolas Caronet al. Molecules, 2019, 24 (3), pp.501. ⟨10.3390/molecules24030501⟩ Article dans une revue inserm-02380544v1
Deciphering the metabolic secret of longevity through the analysis of metabolic response to stress on long-lived species Philippe de Medina Medical Hypotheses, 2019, 122, pp.62-67. ⟨10.1016/j.mehy.2018.10.019⟩ Article dans une revue istex hal-04967584v1
A fast UPLC–HILIC method for an accurate quantiﬁcation of dendrogenin A in human tissues Régis Soules,Fabien Audouard-Combe,Emilie Huc-Claustre,Philippe de Médina,Arnaud Riveset al. Journal of Steroid Biochemistry and Molecular Biology, 2019, 194, pp.105447. ⟨10.1016/j.jsbmb.2019.105447⟩ Article dans une revue istex inserm-02380526v1
The cholesterol-derived metabolite dendrogenin A functionally reprograms breast adenocarcinoma and undifferentiated thyroid cancer cells Mathilde Bauriaud-Mallet,Lavinia Vija-Racaru,Séverine Brillouet,Arnaud Mallinger,Philippe de Médinaet al. Journal of Steroid Biochemistry and Molecular Biology, 2019, 192, pp.105390. ⟨10.1016/j.jsbmb.2019.105390⟩ Article dans une revue inserm-02380538v1
Natural and semisynthetic oxyprenylated aromatic compounds as stimulators or inhibitors of melanogenesis Salvatore Genovese,Francesco Epifano,Philippe de Médina,Nicolas Caron,Arnaud Riveset al. Bioorganic Chemistry, 2019, 87, pp.181-190. ⟨10.1016/j.bioorg.2019.03.026⟩ Article dans une revue inserm-02380542v1
Xenohormesis in early life: New avenues of research to explore anti-aging strategies through the maternal diet Philippe de Medina Medical Hypotheses, 2017, 109, pp.126-130. ⟨10.1016/j.mehy.2017.10.005⟩ Article dans une revue istex hal-04967588v1
Dendrogenin A drives LXR to trigger lethal autophagy in cancers Gregory Segala,Marion David,Philippe de Médina,Mathias Poirot,Nizar Serhanet al. Nature Communications, 2017, 8 (1), pp.1903. ⟨10.1038/s41467-017-01948-9⟩ Article dans une revue inserm-02380591v1
Improvement of 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, cholestane-3β,5α,6β-triol and 6-oxo-cholestan-3β,5α-diol recovery for quantification by GC/MS Régis Soules,Emmanuel Noguer,Luigi Iuliano,Chiara Zerbinati,Julie Leignadieret al. Chemistry and Physics of Lipids, 2017, 207, pp.92-98. ⟨10.1016/j.chemphyslip.2017.05.006⟩ Article dans une revue inserm-02380612v1
Quantitative analysis of the tumor suppressor dendrogenin A using liquid chromatography tandem mass spectrometry Emmanuel Noguer,Régis Soules,Claude Netter,Citra Nagarathinam,Julie Leignadieret al. Chemistry and Physics of Lipids, 2017, 207, pp.81-86. ⟨10.1016/j.chemphyslip.2017.06.010⟩ Article dans une revue inserm-02380602v1
Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor Maud Voisin,Philippe de Médina,Arnaud Mallinger,Florence Dalenc,Emilie Huc-Claustreet al. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (44), pp.E9346-E9355. ⟨10.1073/pnas.1707965114⟩ Article dans une revue hal-02316171v1
Molecular and Biochemical Analysis of the Estrogenic and Proliferative Properties of Vitamin E Compounds Farid Khallouki,Philippe de Médina,Stéphanie Caze-Subra,Kerstin Bystricky,Patrick Balagueret al. Frontiers in Oncology, 2016, 5, ⟨10.3389/fonc.2015.00287⟩ Article dans une revue hal-02271824v1
The NR4A nuclear receptors as potential targets for anti-aging interventions Michael Paillasse,Philippe de Medina Medical Hypotheses, 2015, 84 (2), pp.135-140. ⟨10.1016/j.mehy.2014.12.003⟩ Article dans une revue istex hal-04967581v1
The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells. Shaden A. M. Khalifa,Philippe de Médina,Anna Erlandsson,Hesham R. El-Seedi,Sandrine Silvente-Poirotet al. Biochemical and Biophysical Research Communications, 2014, 446 (3), pp.681-686. ⟨10.1016/j.bbrc.2013.12.134⟩ Article dans une revue inserm-00968932v1
Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism Brigitte Sola,Marc Poirot,Philippe de Médina,Sophie Bustany,Véronique Marsaudet al. Oncotarget, 2013, 4 (6), pp.911-922. ⟨10.18632/oncotarget.1066⟩ Article dans une revue inserm-00968940v1
5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of Tamoxifen in breast cancer cells. Gregory Segala,Philippe de Médina,Luigi Iuliano,Chiara Zerbinati,Michael R. Paillasseet al. Biochemical Pharmacology, 2013, 86 (1), pp.175-89. ⟨10.1016/j.bcp.2013.02.031⟩ Article dans une revue inserm-00822322v1
Technical note: Hapten synthesis, antibody production and development of an enzyme-linked immunosorbent assay for detection of the natural steroidal alkaloid Dendrogenin A. Philippe de Médina,Michael R. Paillasse,Gregory Segala,Talal Al Saati,Jeannine Boyeset al. Biochimie, 2013, 95 (3), pp.482-488. ⟨10.1016/j.biochi.2012.06.001⟩ Article dans une revue istex inserm-00822283v1
Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties. Philippe de Médina,Michael R. Paillasse,Gregory Segala,Maud Voisin,Loubna Mhamdiet al. Nature Communications, 2013, 4, pp.1840. ⟨10.1038/ncomms2835⟩ Article dans une revue inserm-00823974v1
Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles. Michael R. Paillasse,Nathalie Saffon,Heinz Gornitzka,Sandrine Silvente-Poirot,Marc Poirotet al. Journal of Lipid Research, 2012, 53 (4), pp.718-725. ⟨10.1194/jlr.M023689⟩ Article dans une revue inserm-00743457v1
MAPK14/p38α confers irinotecan resistance to TP53-defective cells by inducing survival autophagy. Salome Paillas,Annick Causse,Laetitia Marzi,Philippe de Médina,Marc Poirotet al. Autophagy, 2012, 8 (7), pp.1098-112. ⟨10.4161/auto.20268⟩ Article dans une revue inserm-00705786v1
Importance of cholesterol and oxysterols metabolism in the pharmacology of tamoxifen and other AEBS ligands. Philippe de Médina,Michael R. Paillasse,Gregory Ségala,Farid Khallouki,Severine Brillouetet al. Chemistry and Physics of Lipids, 2011, 164 (6), pp.432-437. ⟨10.1016/j.chemphyslip.2011.05.005⟩ Article dans une revue istex inserm-00743454v1
Auraptene is an inhibitor of cholesterol esterification and a modulator of estrogen receptors. Philippe de Médina,Salvatore Genovese,Michael R. Paillasse,Mahta Mazaheri,Stéphanie Caze-Subraet al. Molecular Pharmacology, 2010, 78 (5), pp.827-36. ⟨10.1124/mol.110.065250⟩ Article dans une revue inserm-00519166v1
Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands. Philippe de Médina,Michael R. Paillasse,Grégory Segala,Marc E. Poirot,Sandrine Silvente-Poirot Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (30), pp.13520-13525. ⟨10.1073/pnas.1002922107⟩ Article dans une revue inserm-00519159v1
Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins. Caroline Subra,David Grand,Karine Laulagnier,Alexandre Stella,Gerard Lambeauet al. Quarterly Reviews of Biophysics, 2010, 34 (3), epub ahead of print. ⟨10.1194/jlr.M003657⟩ Article dans une revue hal-00497229v1
Ligands of the antiestrogen-binding site induce active cell death and autophagy in human breast cancer cells through the modulation of cholesterol metabolism. Philippe de Médina,Bruno Payré,Nadia Boubekeur,Justine Bertrand-Michel,François Tercéet al. Cell Death and Differentiation, 2009, 16 (10), pp.1372-1384. ⟨10.1038/cdd.2009.62⟩ Article dans une revue inserm-00519149v1
Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion. Michael R. Paillasse,Philippe de Médina,Guillaume Amouroux,Loubna Mhamdi,Marc E. Poirotet al. Journal of Lipid Research, 2009, 50 (11), pp.2203-2211. ⟨10.1194/jlr.M800668-JLR200⟩ Article dans une revue inserm-00519146v1
Synthesis of new alkylaminooxysterols with potent cell differentiating activities: identification of leads for the treatment of cancer and neurodegenerative diseases. Philippe de Médina,Michael R. Paillasse,Bruno Payré,Sandrine Silvente-Poirot,Marc E. Poirot Journal of Medicinal Chemistry, 2009, 52 (23), pp.7765-7777. ⟨10.1021/jm901063e⟩ Article dans une revue inserm-00519151v1
Tamoxifen and AEBS ligands induced apoptosis and autophagy in breast cancer cells through the stimulation of sterol accumulation. Philippe de Médina,Sandrine Silvente-Poirot,Marc E. Poirot Autophagy, 2009, 5 (7), pp.1066-1067. ⟨10.4161/auto.5.7.9820⟩ Article dans une revue inserm-00519150v1
Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism. Bruno Payré,Philippe de Médina,Nadia Boubekeur,Loubna Mhamdi,Justine Bertrand-Michelet al. Molecular Cancer Therapeutics, 2008, 7 (12), pp.3707-3718. ⟨10.1158/1535-7163.MCT-08-0507⟩ Article dans une revue inserm-00519145v1
Insights into the cholecystokinin 2 receptor binding site and processes of activation. Michaël Paillasse,Céline Deraeve,Philippe de Médina,Loubna Mhamdi,Gilles Favreet al. Molecular Pharmacology, 2006, 70 (6), pp.1935-1945. ⟨10.1124/mol.106.029967⟩ Article dans une revue inserm-00519168v1
The prototypical inhibitor of cholesterol esterification, Sah 58-035 [3-[decyldimethylsilyl]-n-[2-(4-methylphenyl)-1-phenylethyl]propanamide], is an agonist of estrogen receptors Philippe de Médina,Nadia Boubekeur,Patrick Balaguer,Gilles Favre,Sandrine Silvente-Poirotet al. Journal of Pharmacology and Experimental Therapeutics, 2006, 319 (1), pp.139-149. ⟨10.1124/jpet.106.104349⟩ Article dans une revue inserm-00090770v1
Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. Philippe de Médina,Robert Casper,Jean-François Savouret,Marc E. Poirot Journal of Medicinal Chemistry, 2005, 48 (1), pp.287-291. ⟨10.1021/jm0498194⟩ Article dans une revue istex inserm-00090771v1
Tamoxifen is a potent inhibitor of cholesterol esterification and prevents the formation of foam cells. Philippe de Médina,Bruno Payré,José Bernad,Isabelle Bosser,Bernard Pipyet al. Journal of Pharmacology and Experimental Therapeutics, 2004, 308 (3), pp.1165-1173. ⟨10.1124/jpet.103.060426⟩ Article dans une revue inserm-00090774v1
Multiple targeting by the antitumor drug tamoxifen: a structure-activity study. Philippe de Médina,Gilles Favre,Marc E. Poirot Current Medicinal Chemistry Anticancer Agents, 2004, 4 (6), pp.491-508. ⟨10.2174/1568011043352696⟩ Article dans une revue inserm-00090772v1
Molecular characterization of the microsomal tamoxifen binding site. Blandine Kedjouar,Philippe de Médina,Mustapha Oulad-Abdelghani,Bruno Payré,Sandrine Silvente-Poirotet al. Journal of Biological Chemistry, 2004, 279 (32), pp.34048-34061. ⟨10.1074/jbc.M405230200⟩ Article dans une revue inserm-00090773v1
Synthesis, binding and structure-affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS). Marc E. Poirot,Philippe de Médina,Frédéric Delarue,Jean-Jacques Perie,Alain Klaebeet al. Bioorganic and Medicinal Chemistry, 2000, 8 (8), pp.2007-2016. ⟨10.1016/s0968-0896(00)00119-x⟩ Article dans une revue inserm-00090778v1

Brevet (80)

PHYTOSTEROL DERIVATIVES, AND COMPOSITIONS COMPRISING THE SAME, FOR USE AS MEDICAMENTS Sandrine Silvente-Poirot,Philippe de Medina,M Poirot France, Patent n° : EP2025064259. 2025 Brevet inserm-05110310v1
Methods for the treatment of cancers Sandrine Silvente-Poirot,Julio Buñay,Michel Record,Philippe de Medina,M Poirot France, Patent n° : EP25305623.8. 2025 Brevet inserm-05110314v1
Phytosterol derivatives, and compositions comprising the same, for use as medicaments Marc Poirot,Philippe de Medina,Sandrine Silvente-Poirot France, Patent n° : EP24305827. 2024 Brevet inserm-04773991v1
Methods for the treatment of breast cancer Marc Poirot,Philippe de Medina,Khadijetou Diallo,Sandrine Silvente-Poirot France, Patent n° : EP2430515.8.2024. 2024 Brevet inserm-04773966v1
Radiotraceurs de tomographie par émission de positrons (TEP) de fluoro-oxystérols Marc Poirot,Frédéric Courbon,Mohammad Samadi,Philippe de Medina,Sandrine Silvente-Poirotet al. France, N° de brevet: WO2024146880A1. 2024 Brevet inserm-04773942v1
METHODS AND PHARMACEUTICAL COMPOSITIONS FOR REPROGRAMING IMMUNE ENVIRONMENT IN A SUBJECT IN NEED THEREOF Marc Poirot,Julie Leignadier,Philippe de Medina,Michel Record,Sandrine Silvente-Poirot United States, Patent n° : US2023138400A1. 2023 Brevet inserm-04773900v1
Fluoro-oxysterols positron emission tomography (PET) radiotracers Marc Poirot,Frédéric Courbon,Mohammad Samadi,Philippe de Medina,Sandrine Silvente-Poirotet al. France, Patent n° : European patent, EP23305003.8. 2023 Brevet hal-04842549v1
PROCEDE POUR LA PREPARATION DE DERIVES DE STEROL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Canada, N° de brevet: CA2856609C. 2021 Brevet inserm-04772970v1
METHODS AND PHARMACEUTICAL COMPOSITIONS FOR REPROGRAMING IMMUNE ENVIRONMENT IN A SUBJECT IN NEED THEREOF Marc Poirot,Julie Leignadier,Philippe de Medina,Michel Record,Sandrine Silvente-Poirot United States, Patent n° : US2020016177A1. 2020 Brevet inserm-04773893v1
Dendrogenin A and antineoplastic agents for the treatment of chemosensitive or chemoresistant tumors Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot France, Patent n° : US10188666B2. 2019 Brevet inserm-04773745v1
Dendrogenina A y agentes antineoplásicos para el tratamiento de tumores quimiosensibles o quimiorresistentes Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot España, N° de brevet: ES2734425T3. 2019 Brevet inserm-04773729v1
DENDROGÉNINE A ET AGENTS ANTINÉOPLASTIQUES POUR LE TRAITEMENT DES TUMEURS CHIMIOSENSITIVES OU CHIMIORÉSISTANTES Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot France, N° de brevet: EP3272350B1. 2019 Brevet inserm-04773717v1
MÉTHODES ET COMPOSITIONS PHARMACEUTIQUES PERMETTANT LA REPROGRAMMATION DE L'ENVIRONNEMENT IMMUNITAIRE CHEZ UN SUJET EN AYANT BESOIN Marc Poirot,Julie Leignadier,Philippe de Medina,Michel Record,Sandrine Silvente-Poirot France, N° de brevet: EP3515453A1. 2019 Brevet inserm-04773879v1
甾醇衍生物的制备方法 Marc Poirot,Michaël Paillasse,Philippe de Medina,Sandrine Silvente-Poirot China, Patent n° : CN104039807B. 2018 Brevet inserm-04773150v1
MÉTHODES ET COMPOSITIONS PHARMACEUTIQUES PERMETTANT LA REPROGRAMMATION DE L'ENVIRONNEMENT IMMUNITAIRE CHEZ UN SUJET EN AYANT BESOIN Marc Poirot,Julie Leignadier,Philippe de Medina,Michel Record,Sandrine Silvente-Poirot France, N° de brevet: WO2018055080A1. 2018 Brevet inserm-04773906v1
DENDROGÉNINE A ET AGENTS ANTINÉOPLASTIQUES POUR LE TRAITEMENT DES TUMEURS CHIMIOSENSITIVES OU CHIMIORÉSISTANTES Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot France, N° de brevet: EP3272350A1. 2018 Brevet inserm-04773712v1
Sales de adición de ácidos de 5alfa-hidroxi-6beta-[2-(1H-imidazol-4-il)etilamino]colestan-3beta-ol Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Francia, N° de brevet: ES2650914T3. 2018 Brevet inserm-04772765v1
Endrogenina A y agentes antineoplásicos para el tratamiento de tumores quimiosensibles o quimiorresistentes Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot España, N° de brevet: ES2656913T3. 2018 Brevet inserm-04773723v1
DENDROGÉNINE A ET AGENTS ANTINÉOPLASTIQUES POUR LE TRAITEMENT DES TUMEURS CHIMIOSENSITIVES OU CHIMIORÉSISTANTES Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot France, N° de brevet: EP3041477B1. 2017 Brevet inserm-04773704v1
Process for the preparation of sterol derivatives Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Austria, Patent n° : AU2012342460B2. 2017 Brevet inserm-04772907v1
ACID ADDITION SALTS OF 5a-HYDROXY-6ß-[2-(1H-IMIDAZOL-4-YL)ETHYL AMINO]CHOLESTAN-3ß-OL. Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Mexico, Patent n° : MX351610B. 2017 Brevet inserm-04772804v1
processo para o preparo de derivados de esterol Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Brazil, Patent n° : BR112014012458A2. 2017 Brevet inserm-04772921v1
ACID ADDITION SALTS OF 5ALPHA-HYDROXY-6BETA -[2-(1H-IMIDAZOL-4-YL)ETHYLAMINO]CHOLESTAN-3BETA -OL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : EP2768841B1. 2017 Brevet inserm-04772755v1
Methods for Determining the Oncogenic Condition of Cell, Uses Thereof, and Methods for Treating Cancer Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : US2017176446A1. 2017 Brevet inserm-04772284v1
ステロール誘導体の調製方法 Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : JP6157492B2. 2017 Brevet inserm-04773268v1
Proceso para la preparación de derivados de esterol Marc Poirot,Michaël Paillasse,Philippe de Medina,Sandrine Silvente-Poirot España, N° de brevet: ES2613753T3. 2017 Brevet inserm-04773222v1
PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE STÉROL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, N° de brevet: EP2782923B1. 2016 Brevet inserm-04773181v1
PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Mexico, Patent n° : MX343787B. 2016 Brevet inserm-04773308v1
Process for the preparation of sterol derivatives Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina United States, Patent n° : US9447141B2. 2016 Brevet inserm-04773449v1
化学療法感受性又は化学療法抵抗性腫瘍の治療のためのデンドロゲニンＡ及び抗腫瘍薬 Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot Japan, Patent n° : JP2016532709A. 2016 Brevet inserm-04773739v1
DENDROGÉNINE A ET AGENTS ANTINÉOPLASTIQUES POUR LE TRAITEMENT DES TUMEURS CHIMIOSENSITIVES OU CHIMIORÉSISTANTES Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot France, N° de brevet: EP3041477A1. 2016 Brevet inserm-04773700v1
Dendrogenin A and antineoplastic agents for the treatment of chemosensitive or chemoresistant tumors Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot Australia, Patent n° : AU2014317117A1. 2016 Brevet inserm-04773484v1
MÉTHODES POUR DÉTERMINER L'ÉTAT ONCOGÉNIQUE D'UNE CELLULE, LEURS APPLICATIONS, ET MÉTHODES POUR TRAITER LE CANCER Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, N° de brevet: EP2446276B9. 2016 Brevet inserm-04772270v1
DENDROGENIN A AND ANTINEOPLASTIC AGENTS FOR THE TREATMENT OF CHEMOSENSITIVE OR CHEMORESISTANT TUMORS Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot United States, Patent n° : US2016193233A1. 2016 Brevet inserm-04773751v1
Dendrogenin A and antineoplastic agents for the treatment of chemosensitive or chemoresistant tumors Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot China, Patent n° : CN105611934A. 2016 Brevet inserm-04773695v1
СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ СТЕРИНА Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : RU2014125435A. 2015 Brevet inserm-04773440v1
DENDROGÉNINE A ET AGENTS ANTINÉOPLASIQUES POUR LE TRAITEMENT DE TUMEURS CHIMIOSENSIBLES OU CHIMIORÉSISTANTES Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot France, N° de brevet: WO2015032838A1. 2015 Brevet inserm-04773825v1
КИСЛОТНО-АДДИТИВНЫЕ СОЛИ 5α-ГИДРОКСИ-6β-[2-(1H-ИМИДАЗОЛ-4-ИЛ)ЭТИЛАМИНО]ХОЛЕСТАН-3β-ОЛА Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Russia, Patent n° : RU2014119929A. 2015 Brevet inserm-04772821v1
PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina India, Patent n° : IN976MUN2014A. 2015 Brevet inserm-04773233v1
DENDROGENINE A ET AGENTS ANTINEOPLASIQUES POUR LE TRAITEMENT DE TUMEURS CHIMIOSENSIBLES OU CHIMIORESISTANTES Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot Canada, N° de brevet: CA2922715A1. 2015 Brevet inserm-04773546v1
ACID ADDITION SALTS OF 5ALFA-HYDROXY-6BETA-[2-(1H-IMIDAZOL-4-YL)ETHYL AMINO]CHOLESTAN-3BETA-OL. Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Mexico, Patent n° : MX2014004744A. 2015 Brevet inserm-04772791v1
ステロール誘導体の調製方法 Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Japan, Patent n° : JP2015502934A. 2015 Brevet inserm-04773250v1
PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina South Africa, Patent n° : ZA201403736B. 2015 Brevet inserm-04773467v1
細胞の腫瘍形成状態を決定する方法、その使用、及び癌の治療方法 Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : JP5765587B2. 2015 Brevet inserm-04772280v1
Aminoalkylsterol compounds with antitumoral and neuroprotective activity Marc Poirot,Sandrine Silvente-Poirot,Philippe de Medina France, Patent n° : US8957055B2. 2015 Brevet inserm-04772244v1
METHODS FOR DETERMINING THE ONCOGENIC CONDITION OF CELL, USES THEREOF, AND METHODS FOR TREATING CANCER Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : PL2446276T3. 2015 Brevet inserm-04772282v1
PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Mexico, Patent n° : MX2014006303A. 2014 Brevet inserm-04773301v1
５α−ヒドロキシ−６β−［２−（１Ｈ−イミダゾール−４−イル）エチルアミノ］コレスタン−３β−オールの酸付加塩 Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Japan, Patent n° : JP2014530245A. 2014 Brevet inserm-04772775v1
Acid addition salts of 5alpha-hydroxy-6beta-[2-(1H-imidazol-4-yl)ethylamino]cholestan-3beta-ol Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : AU2012324980A1. 2014 Brevet inserm-04772297v1
ACID ADDITION SALTS OF 5α-HYDROXY-6β-[2-(1H-IMIDAZOL-4-YL)ETHYLAMINO]CHOLESTAN-3β-OL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina South Korea, Patent n° : KR20140083014A. 2014 Brevet inserm-04772786v1
PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES. Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Mexico, Patent n° : MX2014006303A. 2014 Brevet inserm-04773292v1
PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina United States, Patent n° : US2014309417A1. 2014 Brevet inserm-04773447v1
PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina United States, Patent n° : US2014309417A1. 2014 Brevet inserm-04772885v1
ACID ADDITION SALTS OF 5ALPHA-HYDROXY-6BETA-[2-(1H-IMIDAZOL-4-YL)ETHYLAMINO]CHOLESTAN-3BETA-OL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina United States, Patent n° : US2014274984A1. 2014 Brevet inserm-04772841v1
Process for the preparation of sterol derivatives Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina China, Patent n° : CN104039807A. 2014 Brevet inserm-04773135v1
PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE STÉROL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, N° de brevet: EP2782923A1. 2014 Brevet inserm-04773167v1
Acid addition salts of 5[alpha]-hydroxy-6[beta]-[2-(1h-imidazol-4-yl)ethylamino]cholestan-3[beta]-ol Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : CN103958541A. 2014 Brevet inserm-04772748v1
Process for the preparation of sterol derivatives Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Austria, Patent n° : AU2012342460A1. 2014 Brevet inserm-04772895v1
Methods for determining the oncogenic condition of cell, uses thereof, and methods for treating cancer Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : CN102498404B. 2014 Brevet inserm-04772266v1
PROCESS FOR THE PREPARATION OF STEROL DERIVATES Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina South Korea, Patent n° : KR20140098131A. 2014 Brevet inserm-04773285v1
SELS D'ADDITION D'ACIDE DE 5Alpha-HYDROXY-6Beta-[2-(1H-IMIDAZOL-4-YL)- ÉTHYLAMINO]CHOLESTAN-3Beta-OL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, N° de brevet: WO2013057148A1. 2013 Brevet inserm-04772848v1
PROCEDE POUR LA PREPARATION DE DERIVES DE STEROL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Canada, N° de brevet: CA2856609A1. 2013 Brevet inserm-04772952v1
PROCÉDÉ POUR LA PRÉPARATION DE DÉRIVÉS DE STÉROL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, N° de brevet: WO2013076257A1. 2013 Brevet inserm-04773460v1
SELS D'ADDITION D'ACIDE DE 5'-HYDROXY-6'-[2-(1H-IMIDAZOL-4-YL)- ETHYLAMINO]CHOLESTAN-3'-OL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, N° de brevet: CA2852622A1. 2013 Brevet inserm-04772735v1
Aminoalkylsterol compounds with antitumoral and neuroprotective activity Marc Poirot,Sandrine Silvente-Poirot,Philippe de Medina France, Patent n° : US8524694B2. 2013 Brevet inserm-04772236v1
Aminoalkyl sterol compounds having an anti-tumoral and neuroprotective activity Marc Poirot,Sandrine Silvente-Poirot,Philippe de Medina France, Patent n° : US7947668B2. 2011 Brevet inserm-04772230v1
DETECTION DE L'ETAT ONCOGENE DE CELLULES HUMAINES OU DE MAMMIFERES PAR PRESENCE D'UN MARQUEUR ET EVALUATION DE L'ACTIVITE D'UN MEDICAMENT PAR DOSAGE DUDIT MARQUEUR Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : FR2947340B1. 2011 Brevet inserm-04772274v1
METHODES POUR DETERMINER L'ETAT ONCOGENIQUE D'UNE CELLULE, LEURS APPLICATIONS, ET METHODES POUR TRAITER LE CANCER Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : CA2766011A1. 2010 Brevet inserm-04772259v1
Aminoalkylsterol compounds having antitumor and neuroprotective activity Marc Poirot,Sandrine Silvente-Poirot,Philippe de Medina France, Patent n° : JP4601297B2. 2010 Brevet inserm-04772227v1
MÉTHODES POUR DÉTERMINER L'ÉTAT ONCOGÉNIQUE D'UNE CELLULE, LEURS APPLICATIONS, ET MÉTHODES POUR TRAITER LE CANCER Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, N° de brevet: WO2010149941A1. 2010 Brevet inserm-04772286v1
AMINOALKYLSTERINVERBINDUNGEN MIT ANTI-KREBS UND NEUROPROTEKTIVER AKTIVITÄT Marc Poirot,Philippe de Medina,Sandrine Silvente-Poirot France, Patent n° : ATE420888T1. 2009 Brevet inserm-04772185v1
COMPUESTOS AMINOALQUILESTEROLES CON ACTIVIDAD ANTITUMORAL Y NEUROPROTECTORA Marc Poirot,Sandrine Silvente-Poirot,Philippe de Medina France, Patent n° : ES2321287T3. 2009 Brevet inserm-04772212v1
AMINOALKYL STEROL COMPOUNDS HAVING AN ANTI-TUMORAL AND NEUROPROTECTIVE ACTIVITY Marc Poirot,Sandrine Silvente-Poirot,Philippe de Medina France, Patent n° : EP1497309B1. 2009 Brevet inserm-04772209v1
Aminoalkyl sterol compounds having an anti-tumoral and neuroprotective activity Philippe de Medina,Sandrine Silvente-Poirot,Marc Poirot France, Patent n° : AU2003262422B8. 2008 Brevet inserm-04772197v1
COMPOSES AMINOALKYLSTEROLES AVEC ACTIVITE ANTI-TUMEUR ET NEUROPROTECTRICE Marc Poirot,Philippe de Medina,Sandrine Silvente-Poirot France, Patent n° : EP1497309A2. 2005 Brevet inserm-04772177v1
NEW STILBENE DERIVATIVES AND THEIR USE AS ARYL HYDROCARBON RECEPTOR LIGAND ANTAGONISTICS Jean-François Savouret,Marc Poirot,Philippe de Medina,Robert F Casper France, Patent n° : EP1418164A1. 2004 Brevet inserm-04772124v1
STEROL DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND MEDICAMENTS COMPRISING SAME Marc Poirot,Philippe de Medina,Sandrine Silvente-Poirot France, Patent n° : WO03089449A2. 2003 Brevet inserm-04772249v1
Nouveaux derivés de stilbène et leur utilisation en tant que antagonistes des ligands du recepteur des arylhydrocarbures Robert F Casper,Jean-François Savouret,Marc Poirot,Philippe de Medina France, Patent n° : EP03773372A. 2003 Brevet inserm-04772141v1
AMINOALKYL STEROL COMPOUNDS HAVING AN ANTI-TUMORAL AND NEUROPROTECTIVE ACTIVITY Marc Poirot,Philippe de Medina,Sandrine Silvente-Poirot France, Patent n° : CA2481561A1. 2003 Brevet inserm-04772202v1
DERIVES DE STEROLS, LEUR PROCEDE DE PREPARATION ET MEDICAMENTS LES COMPORTANT Marc Poirot,Philippe de Medina France, N° de brevet: FR0204912A. 2002 Brevet inserm-04772155v1

Communication dans un congrès (15)

Chemical synthesis and biochemical properties of cholestane-5α,6β-diol-3-sulfonate, a non-hydrolysable analogue of cholestane-5α,6β-diol-3β-sulfate Philippe de Medina,Silia Ayadi,Regis Soules,Bruno Payre,Sandrine Rup-Jacqueset al. 12th ENOR symposium : Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France Communication dans un congrès inserm-05029639v1
Biochemical and structural evidences that the human glutathion S-transferase A1 catalyzes the biosynthesis of dendrogenins. Silia Ayadi,Georges Ndikoum-Matip,Philippe de Medina,Regis Soules,Virginie Nahoumet al. 12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France Communication dans un congrès inserm-05029665v1
Metabolic switching from tumor promoter activities of oncosterone and 27-hydroxycholesterol to 27-hydroxy-oncosterone with antiproliferative properties Silia Ayadi,Silvia Friedrichs,Regis Soulès,Laly Pucheu,Dieter Lütjohannet al. 12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France Communication dans un congrès inserm-05029635v1
The oxysterol dendrogenin A increases the activation of migratory dendritic cells by acting through the LXRβ. Julio Buñay,Laly Pucheu,Silia Ayadi,Michel Record,Philippe de Medinaet al. 12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France Communication dans un congrès inserm-05029673v1
Synthesis and cellular evaluation of new bi-specific estrogen receptor modulators and ACAT/SOAT inhibitors as anticancer agents Farid Khallouki,M Poirot,Stéphanie Caze-Subra,Kerstin Bystricky,Sandrine Silvente-Poirotet al. 12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France Communication dans un congrès inserm-05029726v1
Combined OCDO/DDA extraction and quantification method for a fast and accurate HPLC-MS analysis Regis Soules,Philippe de Medina,Silia Ayadi,Étienne Chatelut,Sandrine Silvente-Poirotet al. 12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France Communication dans un congrès inserm-05029741v1
GSTA1-1 is a multifunctional enzyme involved in 5,6α-epoxycholesterol conjugation with biological nucleophiles Silia Ayadi,Georges Ndikoum-Matip,Philippe de Medina,Virginie Nahoum,Laurent Maveyraudet al. 11th ENOR symposium, ENOR, Sep 2022, Oslo, Norway Communication dans un congrès inserm-05029750v1
Reprogramming tumor cells with the oxysterol, dendrogenin A, to release immunogenic anti-tumor small extracellular vesicles enriched in exosomes. Julio Buñay,Michel Record,Laly Pucheu,M Poirot,Philippe de Medinaet al. 11th ENOR symposium, ENOR, Sep 2022, Oslo, Norway Communication dans un congrès inserm-05029772v1
Comparative Studies on the metabolism of 5,6-epoxycholesterol, cholestane-3β,5α,6β-triol and Oncosterone in the cancer cell lines MCF-7, MDA-MB-231 and HEPG2. Philippe de Medina,Silia Ayadi,Dieter Lütjohann,Sandrine Silvente-Poirot,M Poirot 11th ENOR symposium, ENOR, Sep 2022, Oslo, Norway Communication dans un congrès inserm-05029763v1
Chemical synthesis and biological properties of cholestane-5α,6β-diol-3-sulfonate, a non-hydrolyzable analogue of cholestane-5α,6β-diol-3-O-sulfate Philippe de Medina,Mohammad Samadi,Silia Ayadi,Sandrine Rup-Jacques,Regis Souleset al. 11th ENOR symposium (European Network for Oxysterol Research), ENOR, Sep 2022, Oslo, Norway Communication dans un congrès inserm-05029757v1
Side chain hydroxylation of cholestane-3β,5α,6β-triol and Oncosterone lead to the production of new endogenous oxysterols potentially involved in breast cancer development. Tifany Lalande,Regis Soules,Sandrine Silvente-Poirot,Philippe de Medina,M Poirot 10th ENOR Symposium – Web Meeting, ENOR, Sep 2021, Web Conf, United Kingdom Communication dans un congrès inserm-05029836v1
Inhibition of oncosterone biosynthesis as a new pharmacological anticancer strategy in breast cancer. Philippe de Medina,Rabea Bartölke,Regis Soules,Sandrine Silvente-Poirot,M Poirot 10th ENOR Symposium – Web Meeting, ENOR, Sep 2021, Web Conf, United Kingdom Communication dans un congrès inserm-05029843v1
Characterization of a cholesterol metabolic switch controlling breast carcinogenesis Philippe de Medina,Silia Ayadi,Emmanuel Noguer,Lisa Barrett,Regis Souleset al. 10th ENOR Symposium – Web Meeting, ENOR, Sep 2021, Web Conf, United Kingdom Communication dans un congrès inserm-05029820v1
New targeting in oxysterol metabolism for triple negative breast cancer therapy. Khadijetou Diallo,Philippe de Medina,Regis Soules,Laly Pucheu,Arnaud Mallingeret al. 10th ENOR Symposium – Web Meeting, ENOR, Sep 2021, Web Conf, United Kingdom Communication dans un congrès inserm-05029825v1
Design, synthesis and cellular evaluation of new bi-specific estrogen receptor modulators and ACAT inhibitors as anticancer agents Farid Khallouki,Guillaume Amouroux,Stéphanie Caze-Subra,Kerstin Bystricky,Patrick Balagueret al. 9th ENOR SYMPOSIUM, Metabolism and Oxysterols: Therapeutics for Lifelong Health, ENOR, Sep 2019, Edinbourg, Ecosse, United Kingdom Communication dans un congrès inserm-05029855v1