Philippe-Henri Secretan Maître de conférences

Publications

Article dans une revue (24)

Hybrid GPP–hospital control strategy for semi-solid extrusion 3D printing of ONC201 chewable units in pediatric oncology Stephanie Ramos,Marina Vignes,Philippe-Henri Secretan,François-Xavier Legrand,Maxime Annereauet al. European Journal of Pharmaceutical Sciences, 2026, 216, pp.107326. ⟨10.1016/j.ejps.2025.107326⟩ Article dans une revue hal-05318721v1
A Risk-Based Framework for Hospital Compounding: Integrating Degradation Mechanisms and Predictive Toxicology Philippe-Henri Secretan,Maxime Annereau,Bernard Do Pharmaceutics, 2025, 17 (9), pp.1202. ⟨10.3390/pharmaceutics17091202⟩ Article dans une revue hal-05314035v1
Stability-Guided Formulation of a Light-Sensitive D-LSD Capsule for Clinical Investigation Bernard Do,Luc Mallet,Maxime Annereau,Danielle Libong,Audrey Solgadiet al. Pharmaceutics, 2025, 17 (6), pp.767. ⟨10.3390/pharmaceutics17060767⟩ Article dans une revue hal-05314044v1
Preformulation evaluation of selumetinib for topical application: skin distribution and photodegradation analysis using MALDI imaging and LC-MS/MS Edith Nicol,Bernard Do,Marina Vignes,Maxime Annereau,Muriel Paulet al. Pharmaceutical Development and Technology, 2024, 29 (8), pp.855-861. ⟨10.1080/10837450.2024.2405829⟩ Article dans une revue hal-04981715v1
Development of a pediatric oral solution of ONC201 using nicotinamide to enhance solubility and stability Maxime Annereau,Philippe-Henri Secretan,Marina Vignes,Stéphanie Ramos,Jacques Grillet al. International Journal of Pharmaceutics, 2024, 667 (Part B), pp.124965. ⟨10.1016/j.ijpharm.2024.124965⟩ Article dans une revue hal-04878417v1
PREFORMULATION EVALUATION OF SELUMETINIB FOR TOPICAL APPLICATION: SKIN DISTRIBUTION AND PHOTODEGRADATION ANALYSIS USING MALDI IMAGING AND LC-MS/MS Edith Nicol,Bernard Do,Marina Vignes,Maxime Annereau,Muriel Paulet al. Pharmaceutical Development and Technology, 2024, 29 (8), pp.855-861. ⟨10.1080/10837450.2024.2405829⟩ Article dans une revue hal-05314030v1
Physicochemical Stability of Doravirine (Pifeltro®): Characterization of Main Degradation Products and Assessment of Stability of Tablets Repackaged in Single-Dose Unit Containers Moïse Houssen,Philippe-Henri Secretan,Loup Nobilet,Kilian Jossot,Laura Guichardet al. Pharmaceutics, 2024, 16 (8), pp.977. ⟨10.3390/pharmaceutics16080977⟩ Article dans une revue hal-05314018v1
Identification of Degradation Products of the New Anticancer Drug Substance ONC201 by Liquid Chromatography–High-Resolution Multistage Mass Spectrometry Maxime Annereau,Marina Vignes,Tahar Sif Eddine Bouchema,Lucas Denis,Audrey Solgadiet al. Chemosensors, 2023, 11 (5), pp.294. ⟨10.3390/chemosensors11050294⟩ Article dans une revue hal-05314012v1
Evolution of the Chronic Venous Leg Ulcer Microenvironment and Its Impact on Medical Devices and Wound Care Therapies Gisele Abreu Coelho,Philippe-Henri Secretan,Lionel Tortolano,Loïc Charvet,Najet Yagoubi Journal of Clinical Medicine, 2023, 12 (17), pp.5605. ⟨10.3390/jcm12175605⟩ Article dans une revue hal-05314003v1
3D-Printed, Liquid-Filled Capsules of Concentrated and Stabilized Polyphenol Epigallocatechin Gallate, Developed in a Clinical Trial Philippe-Henri Secretan,Victoire Vieillard,Olivier Thirion,Maxime Annereau,Hassane Sadou Yayéet al. Antioxidants , 2023, 12 (2), pp.424. ⟨10.3390/antiox12020424⟩ Article dans une revue hal-04099659v1
Molecular Mechanisms Involved in the Chemical Instability of ONC201 and Methods to Counter Its Degradation in Solution Maxime Annereau,Marina Vignes,Lucas Denis,André Rieutord,François-Xavier Legrandet al. Pharmaceutics, 2023, 15 (10), pp.2371. ⟨10.3390/pharmaceutics15102371⟩ Article dans une revue hal-04270374v1
Unequal Behaviour between Hydrolysable Functions of Nirmatrelvir under Stress Conditions: Structural and Theoretical Approaches in Support of Preformulation Studies Philippe-Henri Secretan,Maxime Annereau,Willy Kini-Matondo,Bastien Prost,Jade Prudhommeet al. Pharmaceutics, 2022, 14 (8), pp.1720. ⟨10.3390/pharmaceutics14081720⟩ Article dans une revue hal-03882694v1
Mixed Polymeric Micelles for Rapamycin Skin Delivery Guillaume Le Guyader,Bernard Do,Ivo Rietveld,Pascale Coric,Serge Bouazizet al. Pharmaceutics, 2022, 14 (3), pp.569. ⟨10.3390/pharmaceutics14030569⟩ Article dans une revue hal-03843621v1
Identification of the Major Degradation Pathways of Selumetinib Tahar Sif Eddine Bouchema,Maxime Annereau,Victoire Vieillard,Raphael Boquet,Gisele Abreu Coelhoet al. Pharmaceutics, 2022, 14 (12), pp.2651. ⟨10.3390/pharmaceutics14122651⟩ Article dans une revue hal-04415612v1
Ruxolitinib photodegradation mechanisms by theoretical and experimental chemistry Philippe-Henri Secretan,Joel Schlatter,Salvatore Cisternino,Marie Antignac,Olivier Thirionet al. Journal of Pharmaceutical and Biomedical Analysis, 2021, 197, pp.113983. ⟨10.1016/j.jpba.2021.113983⟩ Article dans une revue hal-03244949v1
Simple Approach to Enhance Green Tea Epigallocatechin Gallate Stability in Aqueous Solutions and Bioavailability: Experimental and Theoretical Characterizations Philippe-Henri Secretan,Olivier Thirion,Hassane Sadou Yayé,Thibaud Damy,Alain Astieret al. Pharmaceuticals, 2021, 14 (12), pp.1242. ⟨10.3390/ph14121242⟩ Article dans une revue hal-03510527v1
Stability of Pentobarbital Hydrogel for Rectal Administration in Pediatric Procedural Sedation Sephora Belo,Justine Touchard,Philippe-Henri Secretan,Fabrice Vidal,Vincent Boudyet al. Hospital Pharmacy, 2020, ⟨10.1177/0018578719901276⟩ Article dans une revue hal-03290925v1
Voriconazole topical cream formulation: evidence for stability and antifungal activity Camille Bouchand,David Nguyen,Philippe-Henri Secretan,Fabrice Vidal,Romain Gueryet al. International Journal of Antimicrobial Agents, 2020, 56 (3), pp.106083. ⟨10.1016/j.ijantimicag.2020.106083⟩ Article dans une revue hal-03492491v1
Post hoc study to investigate the potential causes of poor quality of cardiovascular medicines collected in sub-Saharan countries Philippe-Henri Secretan,Marie Antignac,Najet Yagoubi,Mélisande Bernard,Marie Cécile Perieret al. BMJ Open, 2020, 10 (11), pp.e039252. ⟨10.1136/bmjopen-2020-039252⟩ Article dans une revue hal-03066000v1
Physical and chemical stability of a generic etoposide formulation as an alternative to etoposide phosphate Hassane Sadou Yayé,Lamia Hassani,Philippe-Henri Secrétan,Martine Babiard,Haroun Aouatiet al. Journal of Pharmaceutical and Biomedical Analysis, 2019, 178, pp.112896. ⟨10.1016/j.jpba.2019.112896⟩ Article dans une revue hal-02356006v1
Investigating therapeutic usage of combined Ticagrelor and Aspirin through solid-state and analytical studies Hassane Sadou Yaye,Ivo Rietveld,Maria Barrio,Philippe-Henri Secrétan,Antoine Faucheronet al. European Journal of Pharmaceutical Sciences, 2017, 107, pp.62 - 70. ⟨10.1016/j.ejps.2017.06.031⟩ Article dans une revue hal-01928273v1
Density functional theory and liquid chromatography-multistage mass spectrometry to characterize raltitrexed photo-degradation mechanisms Hassane Sadou-Yayé,Maher Karoui,Philippe-Henri Secrétan,Noureddine Ghermani,Jean-Michel Gilletet al. RSC Advances, 2016, 6 (96), pp.93801-93814. ⟨10.1039/c6ra13144a⟩ Article dans une revue hal-02316986v1
Identification of dabigatran etexilate major degradation pathways by liquid chromatography coupled to multi stage high-resolution mass spectrometry Fatma Amrani,Philippe Henri Secrétan,Hassane Sadou-Yayé,Caroline Aymes-Chodur,Mélisande Bernardet al. RSC Advances, 2015, ⟨10.1039/c5ra04251h⟩ Article dans une revue hal-03514920v1
A comprehensive study of apixaban's degradation pathways under stress conditions using liquid chromatography coupled to multistage mass spectrometry Philippe Henri Secrétan,Hassane Sadou-Yayé,Caroline Aymes-Chodur,Mélisande Bernard,Audrey Solgadiet al. RSC Advances, 2015, ⟨10.1039/c5ra00171d⟩ Article dans une revue hal-03514797v1

Thèse (1)

caractérisation des processus de dégradation de nouveaux anticoagulants et d’un cytotoxique en milieu aqueux avec évaluation des impacts pharmaceutiques et environnementaux Philippe-Henri Secrétan Chimie analytique. Université Paris Saclay (COmUE), 2018. Français. ⟨NNT : 2018SACLS481⟩ Thèse tel-02012160v1