Philippe Lesnik

Identifiants chercheurs

IdHAL :

philippe-lesnik

ORCID :

0000-0002-6909-7715

IdRef :

131219391

ResearcherID :

F-7803-2011

Publications

Article dans une revue (38)

MAIT Cells Promote Cholesterol Excretion Pathways Mitigating Atherosclerosis Hua Wang,Pukar Kc,Kaidi Zhang,Clément Materne,Marie Lhommeet al. Circulation Research, 2025, 136 (9), pp.968 - 981. ⟨10.1161/circresaha.124.325841⟩ Article dans une revue hal-05374486v1
Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions Juliette Tokgozoglu,Valeria Pistorio,Mirko Minini,Pierre-Antoine Soret,Virginie Steunouet al. Cell Death and Disease, 2025, 16 (1), pp.683. ⟨10.1038/s41419-025-08004-1⟩ Article dans une revue hal-05355442v1
ABCG1 orchestrates adipose tissue macrophage plasticity and insulin resistance in obesity by rewiring saturated fatty acid pools Veronica Dahik,Pukar Kc,Clément Materne,Canelle Reydellet,Marie Lhommeet al. Science Translational Medicine, 2024, 16 (777), ⟨10.1126/scitranslmed.adi6682⟩ Article dans une revue (article de synthèse) hal-05064186v1
Profound systemic alteration of the immune phenotype and an immunoglobulin switch in Erdheim–Chester disease in a single-center of 78 patients Fleur Cohen Aubart,Lucie Poupel,Flora Saint-Charles,Frederic Charlotte,Youssef Arsafiet al. Haematologica, 2022, 107 (6), pp.1347-1357. ⟨10.3324/haematol.2021.279118⟩ Article dans une revue hal-03388029v2
Diurnal Interplay between Epithelium Physiology and Gut Microbiota as a Metronome for Orchestrating Immune and Metabolic Homeostasis Juan Jose Martínez-García,Dominique Rainteau,Lydie Humbert,Antonin Lamaziere,Philippe Lesniket al. Metabolites, 2022, 12 (5), pp.390. ⟨10.3390/metabo12050390⟩ Article dans une revue hal-03965688v1
Tolerogenic Dendritic Cells Shape a Transmissible Gut Microbiota that Protects from Metabolic Diseases Emelyne Lécuyer,Tiphaine Le Roy,Aurélie Gestin,Amélie Lacombe,Catherine Philippeet al. Diabetes, 2021, 70 (9), p. 2067-2080. ⟨10.2337/db20-1177⟩ Article dans une revue hal-03252103v1
Ex-Vivo Pharmacological Defatting of the Liver: A Review Claire Goumard,Célia Turco,Mehdi Sakka,Lynda Aoudjehane,Philippe Lesniket al. Journal of Clinical Medicine, 2021, 10 (6), pp.1253. ⟨10.3390/jcm10061253⟩ Article dans une revue hal-03177239v1
Unraveling Host-Gut Microbiota Dialogue and Its Impact on Cholesterol Levels Remy Villette,Pukar Kc,Sophie Beliard,Maria Fernanda Salas Tapia,Dominique Rainteauet al. Frontiers in Pharmacology, 2020, 11, pp.278. ⟨10.3389/fphar.2020.00278⟩ Article dans une revue hal-02569834v1
Distinct Postprandial Bile Acids Responses to a High-Calorie Diet in Men Volunteers Underscore Metabolically Healthy and Unhealthy Phenotypes Antonin Lamazière,Dominique Rainteau,K.C. Pukar,Lydie Humbert,Emilie Gauliardet al. Nutrients, 2020, Diet and Post-prandial Metabolism, 12 (11), pp.3545. ⟨10.3390/nu12113545⟩ Article dans une revue hal-03028253v1
Exploring the Bacterial Impact on Cholesterol Cycle: A Numerical Study Mélanie Bourgin,Simon Labarthe,Aicha Kriaa,Marie Lhomme,Philippe Gérardet al. Frontiers in Microbiology, 2020, 11, pp.1121. ⟨10.3389/fmicb.2020.01121⟩ Article dans une revue hal-02863236v1
Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis Sophie Tran,Ines Baba,Lucie Poupel,Sébastien Dussaud,Martine Moreauet al. Immunity, 2020, 53 (3), pp.627-640.e5. ⟨10.1016/j.immuni.2020.06.003⟩ Article dans une revue hal-02967896v1
Inclusion of endophenotypes in a standard GWAS facilitate a detailed mechanistic understanding of genetic elements that control blood lipid levels. Qianqian Zhang,Zexi Cai,Marie Lhomme,Goutam Sahana,Philippe Lesniket al. Scientific Reports, 2020, 10 (1), pp.18434. ⟨10.1038/s41598-020-75612-6⟩ Article dans une revue hal-03023064v1
Antiatherogenic properties of high-density lipoproteins from arterial plasma are attenuated as compared to their counterparts of venous origin Dominique Bonnefont-Rousselot,Leila Benouda,Randa Bittar,Maryam Darabi-Amin,Pierre Demondionet al. Nutrition, Metabolism and Cardiovascular Diseases, 2020, 30 (1), pp.33-39. ⟨10.1016/j.numecd.2019.07.022⟩ Article dans une revue hal-02965526v1
Interleukin-1β and Risk of Premature Death in Patients With Myocardial Infarction Johanne Silvain,Mathieu Kerneis,Michel Zeitouni,Benoit Lattuca,Sophie Galieret al. Journal of the American College of Cardiology, 2020, 76 (15), pp.1763-1773. ⟨10.1016/j.jacc.2020.08.026⟩ Article dans une revue hal-02964413v1
Gut Microbiome and Space Travelers’ Health: State of the Art and Possible Pro/Prebiotic Strategies for Long-Term Space Missions Silvia Turroni,Marciane Magnani,Pukar Kc,Philippe Lesnik,Hubert Vidalet al. Frontiers in Physiology, 2020, 11, pp.553929. ⟨10.3389/fphys.2020.553929⟩ Article dans une revue (article de synthèse) hal-03105593v1
Targeted invalidation of SR-B1 in macrophages reduces macrophage apoptosis and accelerates atherosclerosis Lauriane Galle-Treger,Martine Moreau,Raphaëlle Ballaire,Lucie Poupel,Thomas Hubyet al. Cardiovascular Research, 2020, 116 (3), pp.554-565. ⟨10.1093/cvr/cvz138⟩ Article dans une revue hal-02967904v1
Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis Lynda Aoudjehane,Jérémie Gautheron,Wilfried Le Goff,Claire Goumard,Julia Gilaizeauet al. Disease Models & Mechanisms, 2020, 13 (4), pp.dmm042663. ⟨10.1242/dmm.042663⟩ Article dans une revue hal-02735664v1
Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease Ma Feng,Maryam Darabi,Emilie Tubeuf,Aurélie Canicio,Marie Lhommeet al. European Journal of Preventive Cardiology, In press, 27 (15), pp.204748731989411. ⟨10.1177/2047487319894114⟩ Article dans une revue hal-02433564v1
Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity Amine Toubal,Badr Kiaf,Lucie Beaudoin,Lucie Cagninacci,Moez Rhimiet al. Nature Communications, 2020, 11 (1), pp.3755. ⟨10.1038/s41467-020-17307-0⟩ Article dans une revue inserm-02948958v1
Epigenetic and Transcriptomic Characterization of Pure Adipocyte Fractions From Obese Pigs Identifies Candidate Pathways Controlling Metabolism Mette Juul Jacobsen,Jakob Havgaard,Christian Anthon,Caroline Mentzel,Susanna Cireraet al. Frontiers in Genetics, 2019, 10, ⟨10.3389/fgene.2019.01268⟩ Article dans une revue hal-03969112v1
The intestinal microbiota regulates host cholesterol homeostasis Tiphaine Le Roy,Emelyne Lécuyer,Benoit Chassaing,Moez Rhimi,Marie Lhommeet al. BMC Biology, 2019, 17 (1), pp.94. ⟨10.1186/s12915-019-0715-8⟩ Article dans une revue hal-02404677v1
Small dense HDLs display potent vasorelaxing activity, reflecting their elevated content of sphingosine-1-phosphate Laurence Persègol,Maryam Darabi,Carolane Dauteuille,Marie Lhomme,Sandrine Chantepieet al. Journal of Lipid Research, 2018, 59 (1), pp.25 - 34. ⟨10.1194/jlr.M076927⟩ Article dans une revue hal-01707695v1
Association of Serum Cholesterol Efflux~Capacity With Mortality in Patients~With ST-Segment~Elevation Myocardial Infarction Gilles Montalescot,Maryse Guerin,Johanne Silvain,Julie Gall,Maryam Darabiet al. Journal of the American College of Cardiology, 2018, 72 (25), pp.3259--3269. ⟨10.1016/j.jacc.2018.09.080⟩ Article dans une revue hal-02359955v1
Modulation of Gr1low monocyte subset impacts insulin sensitivity and weight gain upon high-fat diet in female mice Sophie Béliard,L Le Goff,F Saint-Charles,P Poupel,V Deswaerteet al. International Journal of Obesity, 2017, 41 (12), pp.1805-1814. ⟨10.1038/ijo.2017.179⟩ Article dans une revue hal-01580410v1
Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals Simona Frederiksen,Peter Karlskov-Mortensen,Sameer Pant,Maryse Guerin,Philippe Lesniket al. PLoS ONE, 2017, 12 (6), pp.e0178828. ⟨10.1371/journal.pone.0178828⟩ Article dans une revue hal-03969126v1
Association of Cholesterol Efflux Capacity With Clinical Features of Metabolic Syndrome: Relevance to Atherosclerosis Julie Gall,Eric Frisdal,Randa Bittar,Wilfried Le Goff,Eric Bruckertet al. Journal of the American Heart Association, 2016, 5 (12), ⟨10.1161/JAHA.116.004808⟩ Article dans une revue hal-01406011v1
Extended-Release Niacin/Laropiprant Improves Overall Efficacy of Postprandial Reverse Cholesterol Transport Petra El Khoury,Elisa Waldmann,Thierry Huby,Julie Gall,Philippe Couvertet al. Arteriosclerosis, Thrombosis, and Vascular Biology, 2016, 36 (2), pp.285-294. ⟨10.1161/ATVBAHA.115.306834⟩ Article dans une revue hal-03624977v1
αVβ3 integrin-targeted microSPECT/CT imaging of inflamed atherosclerotic plaques in mice David Vancraeynest,Véronique Roelants,Caroline Bouzin,François-Xavier Hanin,Stephan Walrandet al. EJNMMI Research, 2016, 6, pp.29. ⟨10.1186/s13550-016-0184-9⟩ Article dans une revue hal-01298089v1
The spectrum of neutrophilic dermatoses associated with monoclonal gammopathy: Association with IgA isotype and inflammatory profile Raphael Szalat,Gentiane Monsel,Wilfried Le Goff,Maxime Battistella,Djaouida Bengouffaet al. Journal of The American Academy of Dermatology, 2015, 73 (5), pp.809-820. ⟨10.1016/j.jaad.2015.07.031⟩ Article dans une revue istex hal-03624957v1
Recent patents on hypocholesterolemic therapeutic strategies: an update Aline Potiron,Philippe Gerard,Tiphaine Le Roy,Philippe Lesnik,Emmanuelle Maguinet al. Recent Advances in DNA and Gene Sequences, 2015, 9 (1), pp.36-44. ⟨10.2174/2352092210666151216143459⟩ Article dans une revue (article de synthèse) hal-01536579v1
Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE Laura Bouchareychas,John Pirault,Flora Saint-Charles,Virginie Deswaerte,Tiphaine Le Royet al. Cardiovascular Research, 2015, 108 (1), pp.111-123. ⟨10.1093/cvr/cvv177⟩ Article dans une revue hal-03624947v1
Adipocyte ATP-Binding Cassette G1 Promotes Triglyceride Storage, Fat Mass Growth, and Human Obesity E. Frisdal,Soazig Le Lay,Henri Hooton,Lucie Poupel,Maryline Olivieret al. Diabetes, 2015, ⟨10.2337/db14-0245⟩ Article dans une revue hal-02545916v1
Circulating phospholipid profiling identifies portal contribution to NASH signature in obesity Kavya Anjani,Marie Lhomme,Nataliya Sokolovska,Christine Poitou,Judith Aron-Wisnewskyet al. Journal of Hepatology, 2014, 62 (4), pp.905-912. ⟨10.1016/j.jhep.2014.11.002⟩ Article dans une revue hal-01090208v1
Interleukin-6 Protects Human Macrophages from Cellular Cholesterol Accumulation and Attenuates the Proinflammatory Response Eric Frisdal,Philippe Lesnik,Maryline Olivier,Paul Robillard,M. John Chapmanet al. Journal of Biological Chemistry, 2011, 286 (35), pp.30926-30936. ⟨10.1074/jbc.M111.264325⟩ Article dans une revue hal-03624859v1
Atheroprotective Reverse Cholesterol Transport Pathway Is Defective in Familial Hypercholesterolemia Natacha Bellanger,Alexina Orsoni,Zélie Julia,Natalie Fournier,Eric Frisdalet al. Arteriosclerosis, Thrombosis, and Vascular Biology, 2011, 31 (7), pp.1675-1681. ⟨10.1161/ATVBAHA.111.227181⟩ Article dans une revue hal-03624854v1
Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management M. John Chapman,Henry N Ginsberg,Pierre Amarenco,Felicita Andreotti,Jan Borénet al. European Heart Journal, 2011, 32 (11), pp.1345 - 1361. ⟨10.1093/eurheartj/ehr112⟩ Article dans une revue hal-03330019v1
Cholesteryl Ester Transfer Protein Expression Partially Attenuates the Adverse Effects of SR-BI Receptor Deficiency on Cholesterol Metabolism and Atherosclerosis Majda El Bouhassani,Sophie Gilibert,Martine Moreau,Flora Saint-Charles,Morgan Tréguieret al. Journal of Biological Chemistry, 2011, 286 (19), pp.17227-17238. ⟨10.1074/jbc.M111.220483⟩ Article dans une revue hal-03624849v1
Lipoprotein(a) as a cardiovascular risk factor: current status. Børge G. Nordestgaard,M John Chapman,Kausik Ray,Jan Borén,Felicita Andreottiet al. European Heart Journal, 2010, 31 (23), pp.2844-53. ⟨10.1093/eurheartj/ehq386⟩ Article dans une revue inserm-00578888v1

Communication dans un congrès (1)

Purification and multi-omics characterization of human pre-beta-HDL reveals specific proteomic and lipidomic signature relevant to biological activities Isabelle Guillas,Marie Lhomme,Lucrèce Mathéron,Sandrine Lebreton,Maharajah Ponnaiahet al. european lipoprotein club, EAS, Sep 2018, Tutzing, Germany Communication dans un congrès inserm-04046669v1

Poster de conférence (2)

Genetic testign of familial hypercholesterolemia : monogenic form and polygenic contribution to cardiovascular risk Philippe Couvert,Philippe Giral,Pierre-Yves Boëlle,Valérie Carreau,Sophie Béliardet al. 85. Congress of the European-Atherosclerosis-Society (EAS), Apr 2017, Prague, Czech Republic. Elsevier Ireland Ltd, Atherosclerosis, 263, pp.1, 2017 Poster de conférence hal-02735087v1
Distinct proteomic and lipidomic composition and atheroprotective functionof human plasma pre-b high-density lipoprotein (HDL) Isabelle Guillas,Marie Lhomme,Marie Delbos,Emilie Tubeuf,Lucrèce Matheronet al. 12ième congrès de la Société Francophone d’Athérosclérose NSFA, Jun 2016, Biarritz, France Poster de conférence inserm-04048146v1