Pierre RAY

Publications

Article dans une revue (50)

CFAP251 deletion and ICSI outcome in Tunisian infertile men with multiple morphological abnormalities of the sperm flagellum Wiem Ayed,Sana Chtorou,Nicolas Thierry-Mieg,Wiem Frikha,Khadija Kacem Berjebet al. Middle East Fertility Society Journal, 2026, 31 (1), pp.3. ⟨10.1186/s43043-025-00295-w⟩ Article dans une revue hal-05541550v1
A recurrent loss‐of‐function variant in DRC1 causes non‐syndromic severe asthenozoospermia with favorable intracytoplasmic sperm injection and pregnancy outcomes Célia Tebbakh,Anne‐laure Barbotin,Guillaume Martinez,Angèle Boursier,Zeina Wehbeet al. Andrology, 2025, ⟨10.1111/andr.13837⟩ Article dans une revue hal-04920445v1
Administration of ethiodized poppy seed oil-based contrast agent into the uterus enhances fertilization rate in mice inseminated with low sperm numbers Edgar del Llano,Marlene Rasschaert,Christophe Arnoult,Philippe Robert,Pierre F Rayet al. Human Reproduction, 2025, Online ahead of print. ⟨10.1093/humrep/deaf204⟩ Article dans une revue hal-05354591v1
A comprehensive study of the sperm head defects in MMAF condition and their impact on embryo development in mice Jana Muroňová,Emeline Lambert,Chanyuth Thamwan,Zeina Wehbe,Magali Courtet al. Molecular Human Reproduction, 2025, 31 (1), ⟨10.1093/molehr/gaaf006⟩ Article dans une revue hal-05354598v1
A splice donor variant of GAS8 induces structural disorganization of the axoneme in sperm flagella and leads to nonsyndromic male infertility Zine‐eddine Kherraf,Anne‐laure Barbotin,Guillaume Martinez,Aurélien Mazet,Caroline Cazinet al. Clinical Genetics, 2024, 105 (2), pp.220-225. ⟨10.1111/cge.14450⟩ Article dans une revue hal-04601943v2
Phenotypic continuum and poor intracytoplasmic sperm injection intracytoplasmic sperm injection prognosis in patients harboring HENMT1 variants. Zeina Wehbe,Anne-Laure Barbotin,Angèle Boursier,Caroline Cazin,Jean‐pascal Hograindleuret al. Andrology, 2024, 13 (5), pp.1137-1148. ⟨10.1111/andr.13730⟩ Article dans une revue hal-04700579v2
Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouse Jana Muroňová,Zine-Eddine Kherraf,Elsa Giordani,Simon Eckert,Caroline Cazinet al. eLife, 2024, ⟨10.7554/eLife.86845.2⟩ Article dans une revue hal-04236524v1
Whole genome sequencing identifies a homozygous splicing variant in TDRKH segregating with non-obstructive azoospermia in an Iranian family Amir Amiri-Yekta,Sharanya Sen,Florence Hazane-Puch,Célia Tebbakh,Nathalie Roux-Buissonet al. Clinical Genetics, 2024, 106 (5), pp.625-631. ⟨10.1111/cge.14584⟩ Article dans une revue hal-04633652v1
Sperm fertility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA Charline Vilpreux,Guillaume Martinez,Magali Court,Florence Appaix,Jean-Luc Duteyratet al. eLife, 2024, ⟨10.7554/eLife.94514.1⟩ Article dans une revue hal-04780939v1
CCDC65, encoding a component of the axonemal Nexin-Dynein Regulatory Complex, is required for sperm flagellum structure in humans Fadwa Jreijiri,Emma Cavarocchi,Amir Amiri-Yekta,Caroline Cazin,Seyedeh‐hanieh Hosseiniet al. Clinical Genetics, 2023, 105 (3), pp.317-322. ⟨10.1111/cge.14459⟩ Article dans une revue hal-05401224v1
Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function Denis Dacheux,Guillaume Martinez,Christine Broster Reix,Julie Beurois,Patrick Lorèset al. eLife, 2023, ⟨10.7554/eLife.87698.2⟩ Article dans une revue hal-04241708v1
Genetic causes of macrozoospermia and proposal for an optimized genetic diagnosis strategy based on sperm parameters Alicia Coudert,Caroline Cazin,Amir Amiri-Yekta,Selima Fourati Ben Mustapha,Raoudha Zouariet al. International Journal of Genetics and Genomics, 2023, 50 (7), pp.536-540. ⟨10.1016/j.jgg.2023.04.007⟩ Article dans une revue hal-04256999v2
A recurrent ZP1 variant is responsible for oocyte maturation defect with degenerated oocytes in infertile females Corinne Loeuillet,Magali Dhellemmes,Caroline Cazin,Zine‐eddine Kherraf,Selima Fourati Ben Mustaphaet al. Clinical Genetics, 2022, 102 (1), pp.22-29. ⟨10.1111/cge.14144⟩ Article dans une revue hal-03720194v1
Recommandations de l’AFU et de la SALF concernant l’ évaluation de l’homme infertile Eric Huyghe,Florence Boitrelle,Charlotte Methorst,Roger Mieusset,Pierre Rayet al. Progrès en Urologie, 2021, 31 (3), pp.131-144. ⟨10.1016/j.purol.2020.09.011⟩ Article dans une revue hal-03184036v1
Genetic analyses of a large cohort of infertile patients with globozoospermia, DPY19L2 still the main actor, GGN confirmed as a guest player Tristan Celse,Caroline Cazin,Flore Mietton,Guillaume Martinez,Delphine Martinezet al. Human Genetics, 2021, Molecular Genetics of Male Infertility, 140 (1), pp.43-57. ⟨10.1007/s00439-020-02229-0⟩ Article dans une revue hal-03025179v1
A missense mutation in IFT74, encoding for an essential component for intraflagellar transport of Tubulin, causes asthenozoospermia and male infertility without clinical signs of Bardet-Biedl Syndrome Patrick Lorès,Zine-Eddine Kherraf,Amir Amiri-Yekta,Marjorie Whitfield,Abbas Daneshipouret al. Human Genetics, 2021, 140 (7), pp.1031-1043. ⟨10.1007/s00439-021-02270-7⟩ Article dans une revue hal-03369854v1
Identification and Characterization of the Most Common Genetic Variant Responsible for Acephalic Spermatozoa Syndrome in Men Originating from North Africa Caroline Cazin,Yasmine Boumerdassi,Guillaume Martinez,Selima Fourati Ben Mustapha,Marjorie Whitfieldet al. International Journal of Molecular Sciences, 2021, 22 (4), pp.2187. ⟨10.3390/ijms22042187⟩ Article dans une revue hal-03365058v1
Bi-allelic truncating variants in CFAP206 cause male infertility in human and mouse Qunshan Shen,Guillaume Martinez,Hongbin Liu,Julie Beurois,Huan Wuet al. Human Genetics, 2021, 140 (9), pp.1367-1377. ⟨10.1007/s00439-021-02313-z⟩ Article dans une revue hal-03365264v1
The sodium/proton exchanger SLC9C1 ( sNHE ) is essential for human sperm motility and fertility Emma Cavarocchi,Marjorie Whitfield,Ahmed Chargui,Laurence Stouvenel,Patrick Lorèset al. Clinical Genetics, 2021, 99 (5), pp.684-693. ⟨10.1111/cge.13927⟩ Article dans une revue hal-03369825v1
Genetic diagnosis, sperm phenotype and ICSI outcome in case of severe asthenozoospermia with multiple morphological abnormalities of the flagellum Lucile Ferreux,Mathilde Bourdon,Ahmed Chargui,Alain Schmitt,Laurence Stouvenelet al. Human Reproduction, 2021, 36 (11), pp.2848-2860. ⟨10.1093/humrep/deab200⟩ Article dans une revue hal-03873460v1
Diversity of RNA-Binding Proteins Modulating Post-Transcriptional Regulation of Protein Expression in the Maturing Mammalian Oocyte Marie Christou-Kent,Magali Dhellemmes,Emeline Lambert,Pierre Ray,Christophe Arnoult Cells, 2020, 9 (3), pp.662. ⟨10.3390/cells9030662⟩ Article dans une revue hal-03005093v1
The genetic architecture of morphological abnormalities of the sperm tail Aminata Touré,Guillaume Martinez,Zine-Eddine Kherraf,Caroline Cazin,Julie Beuroiset al. Human Genetics, 2020, ⟨10.1007/s00439-020-02113-x⟩ Article dans une revue hal-03004953v1
Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility Chunyu Liu,Haruhiko Miyata,Yang Gao,Yanwei Sha,Shuyan Tanget al. American Journal of Human Genetics, 2020, 107 (2), pp.330-341. ⟨10.1016/j.ajhg.2020.06.004⟩ Article dans une revue hal-03004971v1
Paternal epigenetics: Mammalian sperm provide much more than DNA at fertilization Emilie Le Blévec,Jana Muroňová,Pierre Ray,Christophe Arnoult Molecular and Cellular Endocrinology, 2020, 518, pp.110964. ⟨10.1016/j.mce.2020.110964⟩ Article dans une revue hal-03005088v1
Biallelic variants in MAATS1 encoding CFAP91, a calmodulin-associated and spoke-associated complex protein, cause severe astheno-teratozoospermia and male infertility Guillaume Martinez,Julie Beurois,Denis Dacheux,Caroline Cazin,Marie Bidartet al. Journal of Medical Genetics, 2020, 57 (10), pp.708-716. ⟨10.1136/jmedgenet-2019-106775⟩ Article dans une revue hal-03004959v1
Genetics of teratozoospermia: Back to the head Julie Beurois,Caroline Cazin,Zine-Eddine Kherraf,Guillaume Martinez,Tristan Celseet al. Best Practice and Research: Clinical Endocrinology and Metabolism, 2020, 34 (6), pp.101473. ⟨10.1016/j.beem.2020.101473⟩ Article dans une revue hal-03004973v1
Pantoprazole, a proton‐pump inhibitor, impairs human sperm motility and capacitation in vitro Jessica Escoffier,Bastien Arnaud,Mayis Kaba,Jean Pascal Hograindleur,Emilie Le Blévecet al. Andrology, 2020, 8 (6), pp.1795-1804. ⟨10.1111/andr.12855⟩ Article dans une revue hal-03005086v1
Enzymatic activity of mouse group X-sPLA2 improves in vitro production of preimplantation bovine embryos Guillaume Martinez,Jean-Pascal Hograindleur,Louise Jeammet,Emilie Le Blévec,Charles Couttonet al. Theriogenology, 2019, 131, pp.113-122. ⟨10.1016/j.theriogenology.2019.03.030⟩ Article dans une revue hal-02324031v1
Bi-allelic Mutations in ARMC2 Lead to Severe Astheno-Teratozoospermia Due to Sperm Flagellum Malformations in Humans and Mice C. Coutton,G. Martinez,Z.-E. Kherraf,A. Amiri-Yekta,M. Boguenetet al. American Journal of Human Genetics, 2019, 104 (2), pp.331-340. ⟨10.1016/j.ajhg.2018.12.013⟩ Article dans une revue hal-02003335v1
CFAP70 mutations lead to male infertility due to severe astheno-teratozoospermia. Julie Beurois,Guillaume Martinez,Caroline Cazin,Zine-Eddine Kherraf,Amir Amiri-Yektaet al. Human Reproduction, 2019, 96 (5), pp.394-401. ⟨10.1093/humrep/dez166⟩ Article dans une revue hal-02322935v1
Whole exome sequencing of men with multiple morphological abnormalities of the sperm flagella reveals novel homozygous QRICH2 mutations Zine‐eddine Kherraf,Caroline Cazin,Charles Coutton,Amir Amiri‐yekta,Guillaume Martinezet al. Clinical Genetics, 2019, 96 (5), pp.394-401. ⟨10.1111/cge.13604⟩ Article dans une revue hal-02347512v1
Genetic causes of male infertility: snapshot on morphological abnormalities of the sperm flagellum Jean-Fabrice Nsota Mbango,Charles Coutton,Christophe Arnoult,Pierre Ray,Aminata Touré Basic and clinical andrology, 2019, 29 (1), ⟨10.1186/s12610-019-0083-9⟩ Article dans une revue hal-02350815v1
Mutations in TTC29, Encoding an Evolutionarily Conserved Axonemal Protein, Result in Asthenozoospermia and Male Infertility Patrick Lorès,Denis Dacheux,Zine-Eddine Kherraf,Jean-Fabrice Nsota Mbango,Charles Couttonet al. American Journal of Human Genetics, 2019, ⟨10.1016/j.ajhg.2019.10.007⟩ Article dans une revue hal-02370384v1
Absence of CFAP69 Causes Male Infertility due to Multiple Morphological Abnormalities of the Flagella in Human and Mouse Frederick Dong,Amir Amiri-Yekta,Guillaume Martinez,Antoine Saut,Julie Teket al. American Journal of Human Genetics, 2018, 102 (4), pp.636 - 648. ⟨10.1016/j.ajhg.2018.03.007⟩ Article dans une revue hal-01877985v1
PATL2 is a key actor of oocyte maturation whose invalidation causes infertility in women and mice Marie Christou‐kent,Zine‐eddine Kherraf,Amir Amiri‐yekta,Emilie Le Blévec,Thomas Karaouzèneet al. EMBO Molecular Medicine, 2018, 10 (5), pp.e8515. ⟨10.15252/emmm.201708515⟩ Article dans une revue hal-01877992v1
Homozygous missense mutation L673P in adenylate kinase 7 (AK7) leads to primary male infertility and multiple morphological anomalies of the flagella but not to primary ciliary dyskinesia Patrick Lorès,Charles Coutton,Elma El Khouri,Laurence Stouvenel,Maelle Giveletet al. Human Molecular Genetics, 2018, 27 (7), pp.1196-1211. ⟨10.1093/hmg/ddy034⟩ Article dans une revue hal-02346745v1
Genomic duplication in the 19q13.42 imprinted region identified as a new genetic cause of intrauterine growth restriction Graciane Petre,Patrick Lorès,Hervé Sartelet,Aurélie Truffot,Brice Poreauet al. Clinical Genetics, 2018, 94 (6), pp.575-580. ⟨10.1111/cge.13449⟩ Article dans une revue hal-02350874v1
Whole-exome sequencing identifies mutations in FSIP2 as a recurrent cause of multiple morphological abnormalities of the sperm flagella Guillaume Martinez,Zine-Eddine Kherraf,Raoudha Zouari,Selima Fourati Ben Mustapha,Antoine Sautet al. Human Reproduction, 2018, 33 (10), pp.1973 - 1984. ⟨10.1093/humrep/dey264⟩ Article dans une revue hal-01877993v1
Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP Jessica Escoffier,Hoi Chang Lee,Sandra Yassine,Raoudha Zouari,Guillaume Martinezet al. Human Molecular Genetics, 2016, 25 (5), pp.878 - 891. ⟨10.1093/hmg/ddv617⟩ Article dans une revue hal-01877966v1
A new mutation identified in SPATA16 in two globozoospermic patients Elias Elinati,Camille Fossard,Ozlem Okutman,Houda Ghédir,Samira Ibala-Romdhaneet al. Journal of Assisted Reproduction and Genetics, 2016, 33 (6), pp.815-820. ⟨10.1007/s10815-016-0715-3⟩ Article dans une revue hal-03680057v1
Microdeletion del(22)(q12.1) excluding the MN1 gene in a patient with craniofacial anomalies Caroline Bosson,Françoise Devillard,Véronique Satre,Klaus Dieterich,Pierre Rayet al. American Journal of Medical Genetics Part A, 2016, 170 (2), pp.498-503. ⟨10.1002/ajmg.a.37450⟩ Article dans une revue istex hal-01980733v1
Comparative testicular transcriptome of wild type and globozoospermic Dpy19l2 knock out mice Thomas Karaouzène,Michèle El Atifi,Jean-Paul Issartel,Marianne Grepillat,Charles Couttonet al. Basic and Clinical Andrology, 2013, 23 (1), pp.7 Article dans une revue inserm-00880088v1
A recurrent deletion of DPY19L2 causes infertility in man by blocking sperm head elongation and acrosome formation. Radu Harbuz,Raoudha Zouari,Virginie Pierre,Mariem Ben Khelifa,Mahmoud Kharoufet al. American Journal of Human Genetics, 2011, 88 (3), pp.351-61. ⟨10.1016/j.ajhg.2011.02.007⟩ Article dans une revue inserm-00588067v1
A new AURKC mutation causing macrozoospermia: implications for human spermatogenesis and clinical diagnosis. Mariem Ben Khelifa,Raoudha Zouari,Radu Harbuz,Lazhar Halouani,Christophe Arnoultet al. Molecular Human Reproduction, 2011, 17 (12), pp.762-8. ⟨10.1093/molehr/gar050⟩ Article dans une revue inserm-00639414v1
DPY19L2 Deletion as a Major Cause of Globozoospermia Isabelle Koscinski,Elias Elinati,Camille Fossard,Claire Redin,Jean Mulleret al. American Journal of Human Genetics, 2011, 88 (3), pp.344-350. ⟨10.1016/j.ajhg.2011.01.018⟩ Article dans une revue hal-05007899v1
Identification of new FOXP3 mutations and prenatal diagnosis of IPEX syndrome. Radu Harbuz,James Lespinasse,Stéphanie Boulet,Christine Francannet,Isabelle Creveauxet al. Prenatal Diagnosis, 2010, 30 (11), pp.1072-8. ⟨10.1002/pd.2613⟩ Article dans une revue istex inserm-00588282v1
Snake venoms as a source of compounds modulating sperm physiology: Secreted phospholipases A2 from Oxyuranus scutellatus scutellatus impact sperm motility, acrosome reaction and in vitro fertilization in mice. Jessica Escoffier,Morgane Couvet,Harold de Pomyers,Pierre F. Ray,Michel Seveet al. Biochimie, 2010, 92 (7), pp.826-36. ⟨10.1016/j.biochi.2010.03.003⟩ Article dans une revue hal-00497569v1
[Function of aurora kinase C (AURKC) in human reproduction] Radu Harbuz,Raoudha Zouari,Klaus Dieterich,Yorgos Nikas,Joël Lunardiet al. Gynécologie Obstétrique & Fertilité, 2009, 37 (6), pp.546-51. ⟨10.1016/j.gyobfe.2009.04.002⟩ Article dans une revue inserm-00515896v1
The Aurora Kinase C c.144delC mutation causes meiosis I arrest in men and is frequent in the North African population. Klaus Dieterich,Raoudha Zouari,Radu Harbuz,François Vialard,Delphine Martinezet al. Human Molecular Genetics, 2009, 18 (7), pp.1301-9. ⟨10.1093/hmg/ddp029⟩ Article dans une revue inserm-00410300v1
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility. Klaus Dieterich,Ricardo Soto Rifo,Anne Karen Faure,Sylviane Hennebicq,Baha Ben Amaret al. Nature Genetics, 2007, 39 (5), pp.661-5. ⟨10.1038/ng2027⟩ Article dans une revue inserm-00381942v1

Poster de conférence (2)

ARMC2 loss impairs cilia structure and leads to primary ciliary dyskinesia symptoms in mouse organs Elsa Giordani,Magali Court,Solène Houdeline,Sylvie Gory-Fauré,Jean Christophe Delloumeet al. RQR symposium, Oct 2025, Quebec (Canada), France Poster de conférence hal-05354595v1
ARMC2: a multifaceted protein involved in both flagella and cilia formation and function. Corinne Loeuillet,Elsa Giordani,Magali Court,Jessica Escoffier,Pierre F. Rayet al. Evolution of Reproductive Sciences – Where Should We Go?, Jul 2024, Dublin, Ireland Poster de conférence hal-04757357v1

Pré-publication, Document de travail (1)

Sperm fertility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA Charline Vilpreux,Guillaume Martinez,Paul Fourquin,Magali Court,Florence Appaixet al. 2024 Pré-publication, Document de travail hal-04757347v1

Communication dans un congrès (2)

3D live cell imaging of whole organoids in time-lapse using intensity diffraction tomography William Pierré,Lionel Hervé,Cédric Allier,Sophie Morales,Sergei Grudininet al. SPIE Photonics Europe, Apr 2022, Strasbourg, France. ⟨10.1117/12.2625734⟩ Communication dans un congrès hal-03874785v1
Deep learning framework applied to optical diffraction tomography (ODT) William Pierré,Lionel Hervé,Cédric Allier,Sophie Morales,Sergei Grudininet al. Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXVIII, SPIE, Mar 2021, Online Only, France. pp.1, ⟨10.1117/12.2582361⟩ Communication dans un congrès hal-03454249v1

Rapport (1)

Rapport sur les causes d'infertilité Vers une stratégie nationale de lutte contre l'infertilité Salomé Berlioux,Samir Hamamah,Geneviève Plu-Bureau,Rachel Levy,Florence Brugnonet al. Ministère de la santé et des sports. 2022 Rapport hal-05190387v1