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A pyronin-based “covalent-assembly” fluorescent probe for sensitive detection of cyanide in pure aqueous media and real water samples
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Assessment of cytotoxic properties of tetrahydroisoquinoline oximes in breast, prostate and glioblastoma cancer cells
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Designing New Natural‐Mimetic Phosphatidic Acid: A Versatile and Innovative Synthetic Strategy for Glycerophospholipid Research
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Oxidative Neutralisation of Sulfur‐Based Chemical Warfare Agents Mediated by a Lipase: From Batch to Flow Reactor
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Detoxification of chemical warfare agents at physiological pH using UiO-66(Zr)/gelatin hydrogel composite
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Article dans une revue
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Fluorogenic detection of cyanide ions in pure aqueous media through an intramolecular crossed-benzoin reaction: limitations unveiled and possible solutions
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Article dans une revue
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Do Not Waste Time─Ensure Success in Your Cross-Linking Mass Spectrometry Experiments before You Begin
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Article dans une revue
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Light-Induced Unlocking Reactivity of Fragments for Fast Target-Guided Synthesis of Carbonic Anhydrase Inhibitors
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Article dans une revue
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Revisiting the Chemistry and Photophysics of 3‐( N ‐Methylpyridinium‐4‐yl)Coumarins for Designing "Covalent‐Assembly" and "Molecular Disassembly" Fluorescent Probes
Vincent Gaumerd
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Article dans une revue
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Detoxification of V‐Nerve Agents Assisted by a Microperoxidase: New Pathway Revealed by the Use of a Relevant VX Simulant
Valmir Baptista da Silva
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Article dans une revue
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Biological response and cell death signaling pathways modulated by tetrahydroisoquinoline-based aldoximes in human cells
Antonio Zandona
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Article dans une revue
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Design and Synthesis of Chemiluminescent Cassettes Based on Energy Transfer
Steven Vertueux
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Philippe Durand
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Article dans une revue
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A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning
Ophélie da Silva
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Article dans une revue
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Metalloenzyme‐Mediated Thiol‐Yne Addition Towards Photoisomerizable Fluorescent Dyes
Alexis Lossouarn
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Article dans une revue
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Flow neutralisation of sulfur-containing chemical warfare agents with Oxone: packed-bed vs. aqueous solution
Antonin Delaune
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Article dans une revue
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One-Pot Synthesis of Diazirines and 15N2-Diazirines from Ketones, Aldehydes and Derivatives: Development and Mechanistic Insight
Quentin Ibert
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Article dans une revue
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Soft and effective detoxification of a VX simulant in a 3D printed basic flow reactor
Sergui Mansour
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Article dans une revue
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Tailored Bioorthogonal and Bioconjugate Chemistry: A Source of Inspiration for Developing Kinetic Target-Guided Synthesis Strategies
Alexis Lossouarn
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Cyrille Sabot
Article dans une revue
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3-Benzoylquinoxalinone as a photoaffinity labelling derivative with fluorogenic properties allowing reaction monitoring under “no-wash” conditions
Madeleine Cauwel
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Article dans une revue
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Maleimide-based metal-free ligation with dienes: a comparative study
Alexis Lossouarn
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Article dans une revue
hal-03010566v1
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Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice
Elisabet Viayna
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Article dans une revue
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Dearomatization of a 3-Hydroxypyridine through an unexpected Oxidative Deformylation Process: an Entry to Aza-cyclohexadienones
Afef Mabrouki
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Article dans une revue
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Chromogranin A preferential interaction with Golgi phosphatidic acid induces membrane deformation and contributes to secretory granule biogenesis
Ophélie Carmon
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Article dans une revue
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Pharmacokinetic Evaluation of Brain Penetrating Morpholine-3-hydroxy-2-pyridine Oxime as an Antidote for Nerve Agent Poisoning
Tamara Zorbaz
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Article dans une revue
hal-02505607v1
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Mono- and Poly-unsaturated Phosphatidic Acid Regulate Distinct Steps of Regulated Exocytosis in Neuroendocrine Cells
Émeline Tanguy
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Article dans une revue
hal-02922310v1
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Fluorophore-assisted click chemistry through copper(I) complexation
Victor Flon
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Article dans une revue
hal-03034414v1
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Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor
Monika Cieslikiewicz-Bouet
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Article dans une revue
hal-02560260v1
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Real-time molecular optical micro-imaging of EGFR mutations using a fluorescent erlotinib based tracer
Maxime Patout
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Xavier Brune
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Article dans une revue
hal-02353026v1
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Investigation of tetrazine reactivity towards C-nucleophiles: pyrazolone-based modification of biomolecules
Kévin Renault
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Clément Guillou
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Pierre-Yves Renard
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Cyrille Sabot
Article dans une revue
hal-02329641v1
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Regioselective Solid-Phase Synthesis of Peptide Analogues Containing 3,4- or 3,5-Disubstituted Isoxazole as s-cis or s-trans Peptide Bond Mimics
Pierrick Bruyat
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Ludovic Jean
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Article dans une revue
hal-02319741v1
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Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3
Killian Oukoloff
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Marina Naldi
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Article dans une revue
hal-02055769v1
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Reinvestigation of the synthesis of “covalent-assembly” type probes for fluoride ion detection. Identification of novel 7-(diethylamino)coumarins with aggregation-induced emission properties
Valentin Quesneau
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Benoît Roubinet
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Pierre-Yves Renard
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Anthony Romieu
Article dans une revue
hal-02320124v1
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Toward an Innovative Treatment of Alzheimer’s Disease: Design of MTDLs Targeting Acetylcholinesterase and α-7 Nicotinic Receptors
Mégane Pons
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Ludovic Jean
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Pierre-Yves Renard
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Article dans une revue
hal-02352595v1
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Detection of Biothiols with a Fast-Responsive and Water-Soluble Pyrazolone-Based Fluorogenic Probe
Kévin Renault
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Pierre-Yves Renard
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Cyrille Sabot
Article dans une revue
hal-02024529v1
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Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection
T.N. Pashirova
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I.V. Zueva
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K.A. Petrov
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Article dans une revue
hal-02024524v1
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Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis
Carles Galdeano
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Nicolas Coquelle
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Monika Cieslikiewicz-Bouet
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Manuela Bartolini
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Belén Pérez
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Article dans une revue
hal-01807857v1
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Covalent Modification of Biomolecules through Maleimide-Based Labeling Strategies
Kévin Renault
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J.W. Fredy
,
Pierre-Yves Renard
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Cyrille Sabot
Article dans une revue
hal-02024527v1
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Potent 3‐Hydroxy‐2‐Pyridine Aldoxime Reactivators of Organophosphate‐Inhibited Cholinesterases with Predicted Blood–Brain Barrier Penetration
Tamara Zorbaz
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Anissa Braïki
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Nikola Marakovic
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Julien Renou
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Eugenio de La Mora
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Article dans une revue
hal-02024542v1
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Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents
Gianluca Santoni
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J. de Sousa
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Eugenio de La Mora
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J. Dias
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Ludovic Jean
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Article dans une revue
hal-02024531v1
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Bifunctional mannoside-glucosinolate glycoconjugates as enzymatically triggered isothiocyanates and FimH ligands
G. Cutolo
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F. Reise
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M. Schuler
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Article dans une revue
hal-02024493v1
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Use of an Air-Stable Cu(I)-NHC Catalyst for the Synthesis of Peptidotriazoles
Pierrick Bruyat
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Arnaud Gautier
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Ludovic Jean
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Pierre-Yves Renard
Article dans une revue
hal-01916360v1
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Photophysical properties of quinoxalin-2(1H)-ones: Application in the preparation of an azide-based fluorogenic probe for the detection of hydrogen sulfide
Kévin Renault
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Pierre-Yves Renard
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Cyrille Sabot
Article dans une revue
hal-02046306v1
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Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox
Paul Hermant
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Damien Bosc
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Catherine Piveteau
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Ronan Gealageas
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Article dans une revue
hal-03054238v1
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Regioselective synthesis of o-triazolyl-1,5-benzodiazepin-2-ones and o-isoxazolyl-1,5-benzodiazepin-2-ones via copper-catalyzed 1,3-dipolar cycloaddition reactions
H. Mtiraoui
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A. Nsira
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M. Msaddek
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Pierre-Yves Renard
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Cyrille Sabot
Article dans une revue
hal-02046301v1
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Selective and sensitive near‐infrared fluorescent probe for acetylcholinesterase imaging [abstract]
Pierre-Yves Renard
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Ludovic Jean
Article dans une revue
hal-02329887v1
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An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice
André-Guilhem Calas
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José Dias
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Catherine Rousseau
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Mélanie Arboléas
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Article dans une revue
istex
hal-02046266v1
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Metal-free oxidative ring contraction of benzodiazepinones: an entry to quinoxalinones
Hasan Mtiraoui
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Morgane Sanselme
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Moncef Msaddek
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Pierre-Yves Renard
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Article dans une revue
hal-02329806v1
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On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach
Thomas Driant
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Florian Nachon
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Cyril Ollivier
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Pierre-Yves Renard
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Etienne Derat
Article dans une revue
hal-01644385v1
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Probing the cholinergic system to understand neurodegenerative diseases
Pierre-Yves Renard
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Ludovic Jean
Article dans une revue
hal-02046305v1
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Azo-based Fluorogenic Probes for Biosensing and Bioimaging: Recent Advances and Upcoming Challenges
Arnaud Chevalier
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Pierre-Yves Renard
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Anthony Romieu
Article dans une revue
hal-01562215v1
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A miniaturized peptidyl-prolyl isomerase enzyme assay
Mirella Vivoli
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Julien Renou
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Isobel H. Norville
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Suraya Diaz
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Article dans une revue
hal-02046314v1
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Synthesis and photophysical properties of iron-carbonyl complex–coumarin conjugates as potential bimodal IR–fluorescent probes
Paulina C. Glowacka
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Nicolas Maindron
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G. Richard Stephenson
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Pierre-Yves Renard
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Article dans une revue
hal-01428754v1
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5-Alkoxyoxazole –A Versatile Building Block in (Bio)organic Synthesis
Laurie-Anne Jouanno
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Kévin Renault
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Cyrille Sabot
,
Pierre-Yves Renard
Article dans une revue
istex
hal-02046218v1
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A selective and sensitive near-infrared fluorescent probe for acetylcholinesterase imaging
Sovy Chao
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Eric Krejci
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Véronique Bernard
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Jacqueline Leroy
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Ludovic Jean
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Article dans une revue
hal-03013508v1
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Readily functionalizable phosphonium-tagged fluorescent coumarins for enhanced detection of conjugates by mass spectrometry
Antoine Lizzul-Jurse
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Marie Hubert-Roux
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Carlos Afonso
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Pierre-Yves Renard
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Article dans une revue
hal-02046223v1
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1,5-Benzodiazepin-2-ones: Investigation of a Family of Photoluminescent Materials
Hasan Mtiraoui
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Rafik Gharbi
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Moncef Msaddek
,
Yann Bretonnière
,
Chantal Andraud
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Article dans une revue
hal-01526233v1
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Improved Access to Huprine Derivatives Functionalized at Position 9
Killian Oukoloff
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Sovy Chao
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Monika Cieslikiewicz-Bouet
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Romain Mougeot
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Ludovic Jean
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Article dans une revue
istex
hal-02046230v1
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Fluorogenic Behaviour of the Hetero-Diels–Alder Ligation of 5-Alkoxyoxazoles with Maleimides and their Applications
Kévin Renault
,
Laurie-Anne Jouanno
,
Antoine Lizzul-Jurse
,
Pierre-Yves Renard
,
Cyrille Sabot
Article dans une revue
istex
hal-02046236v1
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Synthesis and in vitro evaluation of donepezil-based reactivators and analogues for nerve agent-inhibited human acetylcholinesterase
Julien Renou
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José Dias
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Guillaume Mercey
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Tristan Verdelet
,
Catherine Rousseau
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Article dans une revue
hal-02046237v1
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Solution and solid-state fluorescence of 2-(2′-hydroxyphenyl)-1,5-benzodiazepin-2-one (HBD) borate complexes
Hasan Mtiraoui
,
Rafik Gharbi
,
Moncef Msaddek
,
Yann Bretonnière
,
Chantal Andraud
et al.
Article dans une revue
hal-01526238v1
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Fast-Responsive Nitroso-Based Turn-On Probe for Hydrogen Sulfide
Kévin Renault
,
Cyrille Sabot
,
Pierre-Yves Renard
Article dans une revue
istex
hal-02046170v1
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Multi-target directed ligands: Electrophysiological characterization of an anticholinesterase inhibitor coupled to an agonist of α7 nicotinic acetylcholine receptor
Rómulo Aráoz
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Monika Bouet
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Manuela Bartolini
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Nicolas Coquelle
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Jacques-Philippe Colletier
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Article dans une revue
istex
hal-02329901v1
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Rapid Synthesis of Unsymmetrical Sulforhodamines Through Nucleophilic Amination of a Monobrominated Sulfoxanthene Dye
Arnaud Chevalier
,
Kévin Renault
,
Frederic Boschetti
,
Pierre-Yves Renard
,
Anthony Romieu
Article dans une revue
istex
hal-01150274v1
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PET and SPECT radiotracers for Alzheimer's disease
Killian Oukoloff
,
Monika Cieslikiewicz-Bouet
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Sovy Chao
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Emilie da Costa Branquinho
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C. Bouteiller
et al.
Article dans une revue
hal-02046165v1
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Rational Design of Latent Fluorophores from Water-Soluble Hydroxyphenyltriazine Dyes Suitable for Lipase Sensing
Alicia Jacquemet
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Sandra Rihn
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Gilles Ulrich
,
Pierre-Yves Renard
,
Anthony Romieu
et al.
Article dans une revue
istex
hal-01150275v1
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New insights into the kinetic target-guided synthesis of protein ligands
E. Oueis
,
Cyrille Sabot
,
Pierre-Yves Renard
Article dans une revue
hal-02046164v1
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|
|
A FRET-based probe for fluorescence sensing of sulfide/sulfite analytes, using a novel long-wavelength water-soluble 7-hydroxycoumarin as reporter fluorophore
Benoît Roubinet
,
Laëtitia Bailly
,
Emilie Petit
,
Pierre-Yves Renard
,
Anthony Romieu
Article dans une revue
hal-01150270v1
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Azobenzene-caged sulforhodamine dyes: A novel class of 'turn-on' reactive probes for hypoxic tumor cell imaging
Arnaud Chevalier
,
Wen Piao
,
Kenjiro Hanaoka
,
Tetsuo Nagano
,
Pierre-Yves Renard
et al.
Article dans une revue
hal-02046143v1
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A Synthetic Route to 3-(Heteroaryl)-7-hydroxycoumarins Designed for Biosensing Applications
Benoît Roubinet
,
Arnaud Chevalier
,
Pierre-Yves Renard
,
Anthony Romieu
Article dans une revue
istex
hal-01150273v1
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Synthetic Route to Rare Isoindolones Derivatives
Killian Oukoloff
,
Frederic Buron
,
Sylvain Routier
,
Ludovic Jean
,
Pierre-Yves Renard
Article dans une revue
istex
hal-01150276v1
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New 3-(Heteroaryl)-2-iminocoumarin-based Borate Complexes: Synthesis, Photophysical Properties, and Rational Functionalization for Biosensing/Biolabeling Applications
Benoît Roubinet
,
Cédrik Massif
,
Mathieu Moreau
,
F. Boschetti
,
Gilles Ulrich
et al.
Article dans une revue
istex
hal-02046171v1
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Biochemical Characterization of a Caspase-3 Far-red Fluorescent Probe for Non-invasive Optical Imaging of Neuronal Apoptosis
Valérie Jolivel
,
Sébastien Arthaud
,
Béatrice Botia
,
Christophe Portal
,
Bruno Delest
et al.
Article dans une revue
hal-01196843v1
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Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterase
Julien Renou
,
Melanie Loiodice
,
Melanie Arboleas
,
Rachid Baati
,
Ludovic Jean
et al.
Article dans une revue
hal-01150284v1
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|
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Straightforward Access to Water-Soluble Unsymmetrical Sulfoxanthene Dyes: Application to the Preparation of Far-Red Fluorescent Dyes with Large Stokes' Shifts
Arnaud Chevalier
,
Pierre-Yves Renard
,
Anthony Romieu
Article dans une revue
istex
hal-01150280v1
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|
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Straightforward synthesis of bioconjugatable azo dyes. Part 2: Black Hole Quencher-2 (BHQ-2) and BlackBerry Quencher 650 (BBQ-650) scaffolds
Arnaud Chevalier
,
Pierre-Yves Renard
,
Anthony Romieu
Article dans une revue
hal-01150282v1
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Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1
Lucie Aliouane
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Sovy Chao
,
Brizuela Leyre
,
Emmanuel Pfund
,
Cuvillier Olivier
et al.
Article dans une revue
istex
hal-01063240v1
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Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase
Maria Kliachyna
,
Gianluca Santoni
,
Valentin Nussbaum
,
Julien Renou
,
Benoît Sanson
et al.
Article dans une revue
istex
hal-01131268v1
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New insights into the water-solubilization of thiol-sensitive fluorogenic probes based on long-wavelength 7-hydroxycoumarin scaffolds
Benoît Roubinet
,
Pierre-Yves Renard
,
Anthony Romieu
Article dans une revue
hal-01150279v1
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|
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Kondrat'eva ligation: Diels-Alder-based irreversible reaction for bioconjugation
Laurie-Anne Jouanno
,
Arnaud Chevalier
,
Nawal Sekkat
,
Nicolas Perzo
,
Hélène Castel
et al.
Article dans une revue
hal-01144842v1
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|
|
Metal-Free Decarboxylative Hetero-Diels-Alder Synthesis of 3-Hydroxypyridines: A Rapid Access to N-Fused Bicyclic Hydroxypiperidine Scaffolds.
Laurie-Anne Jouanno
,
Vincent Di Mascio
,
Vincent Tognetti
,
Laurent Joubert
,
Cyrille Sabot
et al.
Article dans une revue
hal-00996570v1
|
|
|
Azo-Sulforhodamine Dyes: A Novel Class of Broad Spectrum Dark Quenchers
Arnaud Chevalier
,
Pierre-Yves Renard
,
Anthony Romieu
Article dans une revue
hal-02335871v1
|
|
|
First enzymatic hydrolysis/thio-Michael addition cascade route to synthesis of AChE inhibitors.
Emilia Oueis
,
Florian Nachon
,
Cyrille Sabot
,
Pierre-Yves Renard
Article dans une revue
hal-00996567v1
|
|
|
Reaction site-driven regioselective synthesis of AChE inhibitors
Emilia Oueis
,
Gianluca Santoni
,
Cyril Ronco
,
Olga A. Syzgantseva
,
Vincent Tognetti
et al.
Article dans une revue
hal-02335933v1
|
|
|
Straightforward synthesis of bioconjugatable azo dyes. Part 1: Black Hole Quencher-1 (BHQ-1) scaffold
Arnaud Chevalier
,
Pierre-Yves Renard
,
Anthony Romieu
Article dans une revue
hal-01150281v1
|
|
|
Thermally controlled decarboxylative [4 + 2] cycloaddition between alkoxyoxazoles and acrylic acid: expedient access to 3-hydroxypyridines.
Laurie-Anne Jouanno
,
Vincent Tognetti
,
Laurent Joubert
,
Cyrille Sabot
,
Pierre-Yves Renard
Article dans une revue
hal-00996416v1
|
|
|
Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.
Florian Nachon
,
Eugénie Carletti
,
Cyril Ronco
,
Marie Trovaslet
,
Yvain Nicolet
et al.
Article dans une revue
hal-00996550v1
|
|
|
Universal dark quencher based on "clicked" spectrally distinct azo dyes.
Arnaud Chevalier
,
Julie Hardouin
,
Pierre-Yves Renard
,
Anthony Romieu
Article dans une revue
hal-00996556v1
|
|
|
A novel sulfonated prosthetic group for [18F]-radiolabelling and imparting water solubility of biomolecules and cyanine fluorophores.
Thomas Priem
,
Cédric Bouteiller
,
Davide Camporese
,
Xavier Brune
,
Julie Hardouin
et al.
Article dans une revue
hal-00996532v1
|
|
|
Bioconjugatable azo-based dark-quencher dyes: synthesis and application to protease-activatable far-red fluorescent probes.
Arnaud Chevalier
,
Cédrik Massif
,
Pierre-Yves Renard
,
Anthony Romieu
Article dans une revue
istex
hal-00996530v1
|
|
|
The first comparative study of the ability of different hydrophilic groups to water-solubilize fluorescent BODIPY dyes
Anthony Romieu
,
Cédrik Massif
,
Sandra Rihn
,
Gilles Ulrich
,
Raymond Ziessel
et al.
Article dans une revue
hal-01015523v1
|
|
|
Synthesis, biological evaluation, and in vivo imaging of the first camptothecin-fluorescein conjugate.
Arnaud Chevalier
,
Martine Dubois
,
Vadim Le Joncour
,
Sébastien Dautrey
,
Céline Lecointre
et al.
Article dans une revue
hal-00996547v1
|
|
|
Strategies for the selection of catalytic antibodies against organophosphorus nerve agents.
Ivan Smirnov
,
Alexey Belogurov
,
Alain Friboulet
,
Patrick Masson
,
Alexander Gabibov
et al.
Article dans une revue
istex
hal-00996534v1
|
|
|
The first "ready-to-use" benzene-based heterotrifunctional cross-linker for multiple bioconjugation.
Guillaume Viault
,
Sébastien Dautrey
,
Nicolas Maindron
,
Julie Hardouin
,
Pierre-Yves Renard
et al.
Article dans une revue
hal-00996541v1
|
|
|
Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents.
Julien Renou
,
Guillaume Mercey
,
Tristan Verdelet
,
Emilia Păunescu
,
Emilie Gillon
et al.
Article dans une revue
istex
hal-00996535v1
|
|
|
The first latent green fluorophores for the detection of azoreductase activity in bacterial cultures.
Arnaud Chevalier
,
Claire Mercier
,
Laura Saurel
,
Sylvain Orenga
,
Pierre-Yves Renard
et al.
Article dans une revue
hal-00996553v1
|
|
|
Radiosynthesis and in vivo evaluation of fluorinated huprine derivates as PET radiotracers of acetylcholinesterase
Emilie da Costa Branquinho
,
Guillaume Becker
,
Cédric Bouteiller
,
Ludovic Jean
,
Pierre-Yves Renard
et al.
Article dans une revue
istex
hal-00847401v1
|
|
|
Correction to Expeditious Microwave-Assisted Synthesis of 5-Alkoxyoxazoles from α-Triflyloxy Esters and Nitriles
Laurie-Anne Jouanno
,
Cyrille Sabot
,
Pierre‐yves Renard
Article dans une revue
hal-05504048v1
|
|
|
New insights into the water-solubilisation of fluorophores by post-synthetic "click" and Sonogashira reactions
Cédrik Massif
,
Sébastien Dautrey
,
Alexandre Haefele
,
Raymond Ziessel
,
Pierre-Yves Renard
et al.
Article dans une revue
hal-00996469v1
|
|
|
Synthesis of polysubstituted 3-hydroxypyridines via the revisited hetero-Diels-Alder reaction of 5-alkoxyoxazoles with dienophiles.
Cyrille Sabot
,
Emilia Oueis
,
Xavier Brune
,
Pierre-Yves Renard
Article dans une revue
hal-00996467v1
|
|
|
Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure.
Xavier Brazzolotto
,
Marielle Wandhammer
,
Cyril Ronco
,
Marie Trovaslet
,
Ludovic Jean
et al.
Article dans une revue
hal-00996490v1
|
|
|
Synthesis and reactivity of a bis-sultone cross-linker for peptide conjugation and [18F]-radiolabelling via unusual "double click" approach.
Thomas Priem
,
Cédric Bouteiller
,
David Camporese
,
Anthony Romieu
,
Pierre-Yves Renard
Article dans une revue
hal-00996479v1
|
|
|
Expeditious microwave-assisted synthesis of 5-alkoxyoxazoles from α-triflyloxy esters and nitriles.
Laurie-Anne Jouanno
,
Cyrille Sabot
,
Pierre-Yves Renard
Article dans une revue
hal-00996502v1
|
|
|
Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents
Guillaume Mercey
,
Tristan Verdelet
,
Julien Renou
,
Maria Kliachyna
,
Rachid Baati
et al.
Article dans une revue
hal-01015972v1
|
|
|
Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography.
Cyril Ronco
,
Eugénie Carletti
,
Jacques-Philippe Colletier
,
Martin Weik
,
Florian Nachon
et al.
Article dans une revue
istex
hal-00996475v1
|
|
|
Screening of new huprines--inhibitors of acetylcholinesterases by electrospray ionization ion trap mass spectrometry
Anna Ziemianin
,
Cyril Ronco
,
Romain Dolé
,
Ludovic Jean
,
Pierre-Yves Renard
et al.
Article dans une revue
istex
hal-00996397v1
|
|
|
Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase.
Guillaume Mercey
,
Julien Renou
,
Tristan Verdelet
,
Maria Kliachyna
,
Rachid Baati
et al.
Article dans une revue
hal-00996512v1
|
|
|
Water-soluble red-emitting distyryl-borondipyrromethene (BODIPY) dyes for biolabeling
Song-Lin Niu
,
Cédrik Massif
,
Gilles Ulrich
,
Pierre-Yves Renard
,
Anthony Romieu
et al.
Article dans une revue
istex
hal-00996473v1
|
|
|
Water-solubilisation and bio-conjugation of a red-emitting BODIPY marker
Song Lin Niu
,
Cédrik Massif
,
Gilles Ulrich
,
Raymond Ziessel
,
Pierre-Yves Renard
et al.
Article dans une revue
hal-00991914v1
|
|
|
Design, synthesis and evaluation of new alpha-nucleophiles for the hydrolysis of organophosphorus nerve agents: application to the reactivation of phosphorylated acetylcholinesterase
Géraldine Saint-André
,
Maria Kliachyna
,
Sanjeevarao Kodepelly
,
Ludivine Louise-Leriche
,
Emilie Gillon
et al.
Article dans une revue
istex
hal-01017442v1
|
|
|
Straightforward and efficient synthesis of 3-benzyloxy-4-bromopicolinate ester and 3-benzyloxy-5-bromopicolinate ester, common building blocks for pharmaceuticals and agrochemicals
Tristan Verdelet
,
Guillaume Mercey
,
Nobi Correa
,
Ludovic Jean
,
Pierre-Yves Renard
Article dans une revue
istex
hal-01017528v1
|
|
|
A novel and unusually long-lived chemiluminophore based on the 7-hydroxycoumarin scaffold.
Jan Kočí
,
Virgile Grandclaude
,
Marc Massonneau
,
Jean-Alexandre Richard
,
Anthony Romieu
et al.
Article dans une revue
hal-00991904v1
|
|
|
In Vitro and Ex Vivo Evaluation of Smart Infra-Red Fluorescent Caspase-3 Probes for Molecular Imaging of Cardiovascular Apoptosis
Manuelle Debunne
,
Christophe Portal
,
Bruno Delest
,
Ebba Brakenhielm
,
Françoise Lallemand
et al.
Article dans une revue
inserm-02296580v1
|
|
|
Palladium-Catalyzed Preparation of N-Alkylated Tacrine and Huprine Compounds
Cyril Ronco
,
Ludovic Jean
,
Hakim Outaabout
,
Pierre-Yves Renard
Article dans une revue
istex
hal-01017284v1
|
|
|
Synthesis and luminescence properties of new red-shifted absorption lanthanide(III) chelates suitable for peptide and protein labelling.
Nicolas Maindron
,
Séverine Poupart
,
Maxime Hamon
,
Jean-Baptiste Langlois
,
Nelly Plé
et al.
Article dans une revue
hal-00991910v1
|
|
|
Synthesis of difluoromethylphosphonamidates by direct addition of amine
Lucie Aliouane
,
Baptiste Rigaud
,
Emmanuel Pfund
,
Ludovic Jean
,
Pierre-Yves Renard
et al.
Article dans une revue
istex
hal-01017309v1
|
|
|
N-Fmoc-α-sulfo-β-alanine: a versatile building block for the water solubilisation of chromophores and fluorophores by solid-phase strategy.
Anthony Romieu
,
Thomas Bruckdorfer
,
Guillaume Clavé
,
Virgile Grandclaude
,
Cédrik Massif
et al.
Article dans une revue
hal-00991917v1
|
|
|
First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.
Guillaume Mercey
,
Tristan Verdelet
,
Géraldine Saint-André
,
Emilie Gillon
,
Alain Wagner
et al.
Article dans une revue
hal-00991912v1
|
|
|
New huprine derivatives functionalized at position 9 as highly potent acetylcholinesterase inhibitors.
Cyril Ronco
,
Richard Foucault
,
Emilie Gillon
,
Pierre Bohn
,
Florian Nachon
et al.
Article dans une revue
istex
hal-00991920v1
|
|
|
A versatile access to new halogenated 7-azidocoumarins for photoaffinity labeling: Synthesis and photophysical properties
Emilia Paunescu
,
Ludivine Louise
,
Ludovic Jean
,
Anthony Romieu
,
Pierre-Yves Renard
Article dans une revue
istex
hal-01017388v1
|
|
|
Optimized strategies to synthesize β-cyclodextrin-oxime conjugates as a new generation of organophosphate scavengers.
Romain Le Provost
,
Timo Wille
,
Ludivine Louise
,
Nicolas Masurier
,
Susanne Müller
et al.
Article dans une revue
hal-00991907v1
|
|
|
The first metal-free water-soluble cryptophane-111.
Ténin Traoré
,
Guillaume Clavé
,
Léa Delacour
,
Naoko Kotera
,
Pierre-Yves Renard
et al.
Article dans une revue
hal-00991921v1
|
|
|
Facile and rapid access to linear and truncated microcystin analogues for the implementation of immunoassays.
G. Clavé
,
C. Ronco
,
H. Boutal
,
N. Kreich
,
H. Volland
et al.
Article dans une revue
istex
hal-00991885v1
|
|
|
A comparative study of the self-immolation of para-aminobenzylalcohol and hemithioaminal-based linkers in the context of protease-sensitive fluorogenic probes.
Yves Meyer
,
Jean-Alexandre Richard
,
Bruno Delest
,
Pauline Noack
,
Pierre-Yves Renard
et al.
Article dans une revue
istex
hal-00991894v1
|
|
|
Water solubilization of xanthene dyes by post-synthetic sulfonation in organic media
Anthony Romieu
,
Delphine Tavernier-Lohr
,
S Pellet-Rostaing
,
Marc Lemaire
,
Pierre-Yves Renard
Article dans une revue
istex
hal-01018665v1
|
|
|
A universal and ready-to-use heterotrifunctional cross-linking reagent for facile synthetic access to sophisticated bioconjugates.
Guillaume Clavé
,
Hervé Volland
,
Mélanie Flaender
,
Didier Gasparutto
,
Anthony Romieu
et al.
Article dans une revue
istex
hal-00991898v1
|
|
|
Improved synthetic pathway for the derivatization of huprine scaffold
Cyril Ronco
,
Ludovic Jean
,
Pierre-Yves Renard
Article dans une revue
istex
hal-01019278v1
|
|
|
A HTS assay for the detection of organophosphorus nerve agent scavengers.
Ludivine Louise-Leriche
,
Emilia Paunescu
,
Géraldine Saint-André
,
Rachid Baati
,
Anthony Romieu
et al.
Article dans une revue
istex
hal-00991892v1
|
|
|
A highly sensitive competitive enzyme immunoassay of broad specificity quantifying microcystins and nodularins in water samples
Nathalie Khreich
,
Patricia Lamourette
,
Pierre-Yves Renard
,
Guillaume Clavé
,
François Fenaille
et al.
Article dans une revue
istex
hal-05504060v1
|
|
|
Synthesis and structure–activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors
Cyril Ronco
,
Geoffroy Sorin
,
Florian Nachon
,
Richard Foucault
,
Ludovic Jean
et al.
Article dans une revue
istex
hal-03808202v1
|
|
|
Additions and Corrections
Pierre-Yves Renard
Article dans une revue
istex
hal-03808190v1
|
|
|
Self-cleavable chemiluminescent probes suitable for protease sensing
Jean-Alexandre Richard
,
Ludovic Jean
,
Caroline Schenkels
,
Marc Massonneau
,
Anthony Romieu
et al.
Article dans une revue
istex
hal-03808199v1
|
|
|
Water-Soluble BODIPY Derivatives
Song Lin Niu
,
Gilles Ulrich
,
Raymond Ziessel
,
Agneta Kiss
,
Pierre-Yves Renard
et al.
Article dans une revue
hal-05504058v1
|
|
|
Synthesis of a (+)-anatoxin-a analogue for monoclonal antibodies production
Mickael Marc
,
Francis Outurquin
,
Pierre-Yves Renard
,
Christophe Créminon
,
Xavier Franck
Article dans une revue
istex
hal-05504052v1
|
|
|
Thyroid hormone improves postischaemic recovery of function while limiting apoptosis: a new therapeutic approach to support hemodynamics in the setting of ischaemia-reperfusion?
Constantinos Pantos
,
Iordanis Mourouzis
,
Theodosios Saranteas
,
Guillaume Clavé
,
Heidi Ligeret
et al.
Article dans une revue
istex
hal-05504050v1
|
|
|
Synthesis and structure–activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors
Cyril Ronco
,
Geoffroy Sorin
,
Florian Nachon
,
Richard Foucault
,
Ludovic Jean
et al.
Article dans une revue
istex
hal-05504054v1
|
|
|
Additions and corrections
Pierre-Yves Renard
,
Anthony Romieu
,
S. Poupart
,
Philippe A. Peixoto
Article dans une revue
istex
hal-05504066v1
|
|
|
Straightforward Access to Protected syn α‐Amino‐β‐hydroxy Acid Derivatives
Jignesh Patel
,
Guillaume Clavé
,
Pierre‐yves Renard
,
Xavier Franck
Article dans une revue
istex
hal-05504070v1
|
|
|
A novel heterotrifunctional peptide-based cross-linking reagent for facile access to bioconjugates. Applications to peptide fluorescent labelling and immobilisation
Guillaume Clavé
,
Hervé Boutal
,
Antoine Hoang
,
François Perraut
,
Hervé Volland
et al.
Article dans une revue
istex
hal-05504064v1
|
|
|
Latent Fluorophores Based on a Self-Immolative Linker Strategy and Suitable for Protease Sensing
Jean-Alexandre Richard
,
Yves Meyer
,
Valérie Jolivel
,
Marc Massonneau
,
Raphaël Dumeunier
et al.
Article dans une revue
istex
hal-05504068v1
|
|
|
Development of a New Nonpeptidic Self-Immolative Spacer. Application to the Design of Protease Sensing Fluorogenic Probes
Yves Meyer
,
Jean-Alexandre Richard
,
Marc Massonneau
,
Pierre-Yves Renard
,
Anthony Romieu
Article dans une revue
hal-05504067v1
|
|
|
7-Hydroxycoumarin−Hemicyanine Hybrids: A New Class of Far-Red Emitting Fluorogenic Dyes
Jean-Alexandre Richard
,
Marc Massonneau
,
Pierre-Yves Renard
,
Anthony Romieu
Article dans une revue
hal-05504063v1
|
|
|
Postsynthetic Derivatization of Fluorophores with α-Sulfo-β-alanine Dipeptide Linker. Application to the Preparation of Water-Soluble Cyanine and Rhodamine Dyes
Anthony Romieu
,
Dominique Brossard
,
Maxime Hamon
,
Hakim Outaabout
,
Christophe Portal
et al.
Article dans une revue
istex
hal-05504069v1
|
|
|
Novel Water-Soluble Near-Infrared Cyanine Dyes: Synthesis, Spectral Properties, and Use in the Preparation of Internally Quenched Fluorescent Probes
Cédric Bouteiller
,
Guillaume Clavé
,
Aude Bernardin
,
Bertrand Chipon
,
Marc Massonneau
et al.
Article dans une revue
istex
hal-05504072v1
|
|
|
Chemiluminescent Probe for the in Vitro Detection of Protease Activity
Jean-Alexandre Richard
,
Ludovic Jean
,
Anthony Romieu
,
Marc Massonneau
,
Pauline Noack-Fraissignes
et al.
Article dans une revue
hal-05504071v1
|
|
|
Latent fluorophores based on a Mannich cyclisation trigger
Guillaume Clavé
,
Aude Bernardin
,
Marc Massonneau
,
Pierre-Yves Renard
,
Anthony Romieu
Article dans une revue
istex
hal-05504038v1
|
|
|
Aminopropargyl derivative of terpyridine-bis(methyl-enamine) tetraacetic acid chelate of europium (Eu (TMT)-AP3): a new reagent for fluorescent labelling of proteins and peptides
Philippe Peixoto
,
Marc Massonneau
,
Pierre-Yves Renard
,
Anthony Romieu
Article dans une revue
istex
hal-05504073v1
|
|
|
Aryldithioethyloxycarbonyl (Ardec): A New Family of Amine Protecting Groups Removable under Mild Reducing Conditions and Their Applications to Peptide Synthesis
Milaine Lapeyre
,
Jérôme Leprince
,
Marc Massonneau
,
Hassan Oulyadi
,
Pierre-Yves Renard
et al.
Article dans une revue
istex
hal-01962803v1
|
|
|
Synthesis and post-synthetic derivatization of a cyanine-based amino acid. Application to the preparation of a novel water-soluble NIR dye
Bertrand Chipon
,
Guillaume Clavé
,
Cédric Bouteiller
,
Marc Massonneau
,
Pierre-Yves Renard
et al.
Article dans une revue
istex
hal-05504032v1
|
|
|
Synthesis and post-synthetic derivatization of a cyanine-based amino acid. Application to the preparation of a novel water-soluble NIR dye
Bertrand Chipon
,
Guillaume Clavé
,
Cédric Bouteiller
,
Marc Massonneau
,
Pierre-Yves Renard
et al.
Article dans une revue
istex
hal-05504091v1
|
|
|
Aryldithioethyloxycarbonyl(Ardec) : a new family of aminoe protecting groups removable under mild reducing conditions and their applications to peptide synthesis.
M. Lapeyre
,
Jérôme Leprince
,
M. Massonneau
,
Hassan Oulyadi
,
Pierre-Yves Renard
et al.
Chemistry - A European Journal, 2006, 12, pp.3655-3671
Article dans une revue
hal-00023718v1
|
|
|
Immunologically driven antibodies chemical engineering: design and synthesis of a hapten aimed at nerve agent hydrolysis
Florence Jovic
,
Ludivine Louise
,
Charles Mioskowski
,
Pierre-Yves Renard
Article dans une revue
istex
hal-05504029v1
|
|
|
Lewis Acid Catalyzed Room-Temperature Michaelis–Arbuzov Rearrangement
Pierre-Yves Renard
,
Philippe Vayron
,
Eric Leclerc
,
Alain Valleix
,
Charles Mioskowski
Article dans une revue
istex
hal-02345149v1
|
|
|
Design and Synthesis of Chemiluminescent Probes for the Detection of Cholinesterase Activity
Stéphane Sabelle
,
Pierre-Yves Renard
,
Karine Pecorella
,
Sophie de Suzzoni-Dézard
,
Christophe Créminon
et al.
Article dans une revue
istex
hal-05504025v1
|
|
|
Stereoselective access to polyfunctionalized decalins
Cyrille Poirel
,
P.Y. Renard
,
J.Y. Lallemand
Tetrahedron Letters, 1994, 35 (35), pp.6485-6488
Article dans une revue
hal-02710197v1
|