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Pierre-Yves renard

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Revisiting the Chemistry and Photophysics of 3‐( N ‐Methylpyridinium‐4‐yl)Coumarins for Designing "Covalent‐Assembly" and "Molecular Disassembly" Fluorescent Probes

Vincent Gaumerd , Kévin Renault , Pierre‐yves Renard , Anthony Romieu
ChemPhotoChem, 2024, 8 (5), ⟨10.1002/cptc.202300324⟩
Journal articles hal-04574555v1
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Design and Synthesis of Chemiluminescent Cassettes Based on Energy Transfer

Steven Vertueux , Alexandre Haefele , Kathleen Solmont , Philippe Durand , Pierre‐yves Renard
European Journal of Organic Chemistry, 2023, 26 (13), pp.e202201401. ⟨10.1002/ejoc.202201401⟩
Journal articles hal-04059368v1
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Biological response and cell death signaling pathways modulated by tetrahydroisoquinoline-based aldoximes in human cells

Antonio Zandona , Josip Madunić , Katarina Miš , Nikola Maraković , Pierre Dubois-Geoffroy
Toxicology, 2023, 494, pp.153588. ⟨10.1016/j.tox.2023.153588⟩
Journal articles hal-04635900v1
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A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning

Ophélie da Silva , Nicolas Probst , Christophe Landry , Anne-Sophie Hanak , Pierre Warnault
Journal of Medicinal Chemistry, 2022, 65 (6), pp.4649-4666. ⟨10.1021/acs.jmedchem.1c01748⟩
Journal articles hal-03706969v1
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Metalloenzyme‐Mediated Thiol‐Yne Addition Towards Photoisomerizable Fluorescent Dyes

Alexis Lossouarn , Chloé Puteaux , Laetitia Bailly , Vincent Tognetti , Laurent Joubert
Chemistry - A European Journal, inPress, ⟨10.1002/chem.202202180⟩
Journal articles hal-03808088v1
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Soft and effective detoxification of a VX simulant in a 3D printed basic flow reactor

Sergui Mansour , Antonin Delaune , Maxime Manneveau , Baptiste Picard , Amélie Claudel
Green Chemistry, 2021, pp.7522-7527. ⟨10.1039/D1GC01961A⟩
Journal articles hal-03353830v1
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One-Pot Synthesis of Diazirines and 15N2-Diazirines from Ketones, Aldehydes and Derivatives: Development and Mechanistic Insight

Quentin Ibert , Madeleine Cauwel , Thomas Glachet , Tony Tite , Patricia Le Nahenec-Martel
Advanced Synthesis and Catalysis, 2021, 363 (18), pp.4390-4398. ⟨10.1002/adsc.202100679⟩
Journal articles hal-03331796v1
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3-Benzoylquinoxalinone as a photoaffinity labelling derivative with fluorogenic properties allowing reaction monitoring under “no-wash” conditions

Madeleine Cauwel , Clément Guillou , Kévin Renault , Damien Schapman , Magalie Bénard
Chemical Communications, 2021, 57 (32), pp.3893-3896. ⟨10.1039/D1CC01072G⟩
Journal articles hal-03419993v1
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Flow neutralisation of sulfur-containing chemical warfare agents with Oxone: packed-bed vs. aqueous solution

Antonin Delaune , Sergui Mansour , Baptiste Picard , Philippe Carrasqueira , Isabelle Chataigner
Green Chemistry, 2021, 23 (8), pp.2925-2930. ⟨10.1039/D1GC00449B⟩
Journal articles hal-03353823v1
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Tailored Bioorthogonal and Bioconjugate Chemistry: A Source of Inspiration for Developing Kinetic Target-Guided Synthesis Strategies

Alexis Lossouarn , Pierre-Yves Renard , Cyrille Sabot
Bioconjugate Chemistry, 2021, 32 (1), pp.63-72. ⟨10.1021/acs.bioconjchem.0c00568⟩
Journal articles hal-03419994v1

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

Elisabet Viayna , Nicolas Coquelle , Monika Cieslikiewicz-Bouet , Pedro Cisternas , Carolina Oliva
Journal of Medicinal Chemistry, 2020, ⟨10.1021/acs.jmedchem.0c01775⟩
Journal articles hal-03094189v1
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Dearomatization of a 3-Hydroxypyridine through an unexpected Oxidative Deformylation Process: an Entry to Aza-cyclohexadienones

Afef Mabrouki , Patricia Le Nahenec-Martel , Abdelkader Kriaa , Ahmed Hedhli , Pierre-Yves Renard
SYNLETT, 2020, 31 (15), pp.1497-1500. ⟨10.1055/s-0040-1706870⟩
Journal articles hal-03010593v1
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Fluorophore-assisted click chemistry through copper(I) complexation

Victor Flon , Magalie Bénard , Damien Schapman , Ludovic Galas , Pierre-Yves Renard
Biomolecules, 2020, Novel Approaches in Biomolecule Labeling, 10 (4), pp.619. ⟨10.3390/biom10040619⟩
Journal articles hal-03034414v1

Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor

Monika Cieslikiewicz-Bouet , Marina Naldi , Manuela Bartolini , Belén Pérez , Denis Servent
Biochemical Pharmacology, 2020, 177, ⟨10.1016/j.bcp.2020.114010⟩
Journal articles hal-02560260v1
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Mono- and Poly-unsaturated Phosphatidic Acid Regulate Distinct Steps of Regulated Exocytosis in Neuroendocrine Cells

Émeline Tanguy , Pierre Costé de Bagneaux , Nawal Kassas , Mohamed-Raafet Ammar , Qili Wang
Cell Reports, 2020, 32 (7), pp.108026. ⟨10.1016/j.celrep.2020.108026⟩
Journal articles hal-02922310v1
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Maleimide-based metal-free ligation with dienes: a comparative study

Alexis Lossouarn , Kévin Renault , Laëtitia Bailly , Axel Frisby , Patricia Le Nahenec-Martel
Organic & Biomolecular Chemistry, 2020, 18 (20), pp.3874-3887. ⟨10.1039/D0OB00403K⟩
Journal articles hal-03010566v1

Pharmacokinetic Evaluation of Brain Penetrating Morpholine-3-hydroxy-2-pyridine Oxime as an Antidote for Nerve Agent Poisoning

Tamara Zorbaz , Petra Mišetić , Nicolas Probst , Suzana Žunec , Antonio Zandona
ACS Chemical Neuroscience, 2020, 11 (7), pp.1072-1084. ⟨10.1021/acschemneuro.0c00032⟩
Journal articles hal-02505607v1
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Chromogranin A preferential interaction with Golgi phosphatidic acid induces membrane deformation and contributes to secretory granule biogenesis

Ophélie Carmon , Fanny Laguerre , Lina Riachy , Charlène Delestre-Delacour , Qili Wang
FASEB Journal, 2020, 34 (5), pp.6769-6790. ⟨10.1096/fj.202000074R⟩
Journal articles hal-02525074v1

Investigation of tetrazine reactivity towards C-nucleophiles: pyrazolone-based modification of biomolecules

Kévin Renault , Clément Guillou , Pierre-Yves Renard , Cyrille Sabot
Organic & Biomolecular Chemistry, 2019, 17 (2), pp.388-396. ⟨10.1039/C8OB02108B⟩
Journal articles hal-02329641v1

Real-time molecular optical micro-imaging of EGFR mutations using a fluorescent erlotinib based tracer

Maxime Patout , Florian Guisier , Xavier Brune , Pierre Bohn , Anthony Romieu
BMC Pulmonary Medicine, 2019, 19, pp.3. ⟨10.1186/s12890-018-0760-z⟩
Journal articles hal-02353026v1

Toward an Innovative Treatment of Alzheimer’s Disease: Design of MTDLs Targeting Acetylcholinesterase and α-7 Nicotinic Receptors

Mégane Pons , Sylvie Chalon , Ludovic Jean , Pierre-Yves Renard , Frederic Buron
Proceedings, 2019, 22 (1), pp.88. ⟨10.3390/proceedings2019022088⟩
Journal articles hal-02352595v1

Diverted Natural Lossen-type Rearrangement for Bioconjugation through in Situ Myrosinase-Triggered Isothiocyanate Synthesis

Jean Wilfried Fredy , Giuliano Cutolo , Benjamin Poret , Reine Nehmé , Marie Hubert-Roux
Bioconjugate Chemistry, 2019, 30 (5), pp.1385-1394. ⟨10.1021/acs.bioconjchem.9b00153⟩
Journal articles hal-02280045v1
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Reinvestigation of the synthesis of “covalent-assembly” type probes for fluoride ion detection. Identification of novel 7-(diethylamino)coumarins with aggregation-induced emission properties

Valentin Quesneau , Benoît Roubinet , Pierre-Yves Renard , Anthony Romieu
Tetrahedron Letters, 2019, 60 (48), pp.151279. ⟨10.1016/j.tetlet.2019.151279⟩
Journal articles hal-02320124v1
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Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3

Killian Oukoloff , Nicolas Coquelle , Manuela Bartolini , Marina Naldi , Rémy Le Guével
European Journal of Medicinal Chemistry, 2019, 168, pp.58-77. ⟨10.1016/j.ejmech.2018.12.063⟩
Journal articles hal-02055769v1

Regioselective Solid-Phase Synthesis of Peptide Analogues Containing 3,4- or 3,5-Disubstituted Isoxazole as s-cis or s-trans Peptide Bond Mimics

Pierrick Bruyat , Ludovic Jean , Pierre-Yves Renard
European Journal of Organic Chemistry, 2019, 2019 (20), pp.3134-3141. ⟨10.1002/ejoc.201900378⟩
Journal articles hal-02319741v1

Covalent Modification of Biomolecules through Maleimide-Based Labeling Strategies

Kévin Renault , J.W. Fredy , Pierre-Yves Renard , Cyrille Sabot
Bioconjugate Chemistry, 2018, 29 (8), pp.2497-2513. ⟨10.1021/acs.bioconjchem.8b00252⟩
Journal articles hal-02024527v1

Potent 3‐Hydroxy‐2‐Pyridine Aldoxime Reactivators of Organophosphate‐Inhibited Cholinesterases with Predicted Blood–Brain Barrier Penetration

Tamara Zorbaz , Anissa Braïki , Nikola Marakovic , Julien Renou , Eugenio de La Mora
Chemistry - A European Journal, 2018, 24 (38), pp.9675-9691. ⟨10.1002/chem.201801394⟩
Journal articles hal-02024542v1

Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis

Carles Galdeano , Nicolas Coquelle , Monika Cieslikiewicz-Bouet , Manuela Bartolini , Belén Pérez
Molecules, 2018, 23 (3), pp.634. ⟨10.3390/molecules23030634⟩
Journal articles hal-01807857v1

Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection

T.N. Pashirova , Anissa Braïki , I.V. Zueva , K.A. Petrov , V.M. Babaev
Journal of Controlled Release, 2018, 290, pp.102-111. ⟨10.1016/j.jconrel.2018.10.010⟩
Journal articles hal-02024524v1

Detection of Biothiols with a Fast-Responsive and Water-Soluble Pyrazolone-Based Fluorogenic Probe

Kévin Renault , Pierre-Yves Renard , Cyrille Sabot
European Journal of Organic Chemistry, 2018, 2018 (46), pp.6494-6498. ⟨10.1002/ejoc.201801157⟩
Journal articles hal-02024529v1

Use of an Air-Stable Cu(I)-NHC Catalyst for the Synthesis of Peptidotriazoles

Pierrick Bruyat , Arnaud Gautier , Ludovic Jean , Pierre-Yves Renard
Journal of Organic Chemistry, 2018, 83 (21), pp.13515-13522. ⟨10.1021/acs.joc.8b01490⟩
Journal articles hal-01916360v1

Bifunctional mannoside-glucosinolate glycoconjugates as enzymatically triggered isothiocyanates and FimH ligands

G. Cutolo , F. Reise , M. Schuler , R. Nehmé , G. Despras
Organic & Biomolecular Chemistry, 2018, 16 (26), pp.4900-4913. ⟨10.1039/C8OB01128A⟩
Journal articles hal-02024493v1

Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents

Gianluca Santoni , J. de Sousa , Eugenio de La Mora , J. Dias , Ludovic Jean
Journal of Medicinal Chemistry, 2018, 61 (17), pp.7630-7639. ⟨10.1021/acs.jmedchem.8b00592⟩
Journal articles hal-02024531v1

Photophysical properties of quinoxalin-2(1H)-ones: Application in the preparation of an azide-based fluorogenic probe for the detection of hydrogen sulfide

Kévin Renault , Pierre-Yves Renard , Cyrille Sabot
New Journal of Chemistry, 2017, 41 (18), pp.10432-10437. ⟨10.1039/c7nj01893b⟩
Journal articles hal-02046306v1

Regioselective synthesis of o-triazolyl-1,5-benzodiazepin-2-ones and o-isoxazolyl-1,5-benzodiazepin-2-ones via copper-catalyzed 1,3-dipolar cycloaddition reactions

H. Mtiraoui , A. Nsira , M. Msaddek , Pierre-Yves Renard , Cyrille Sabot
Comptes Rendus. Chimie, 2017, 20 (7), pp.747-757. ⟨10.1016/j.crci.2017.02.004⟩
Journal articles hal-02046301v1
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Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox

Paul Hermant , Damien Bosc , Catherine Piveteau , Ronan Gealageas , Baovy Lam
Journal of Medicinal Chemistry, 2017, 60 (21), pp.9067-9089. ⟨10.1021/acs.jmedchem.7b01444⟩
Journal articles hal-03054238v1

A miniaturized peptidyl-prolyl isomerase enzyme assay

Mirella Vivoli , Julien Renou , Arnaud Chevalier , Isobel H. Norville , Suraya Diaz
Analytical Biochemistry, 2017, 536, pp.59-68. ⟨10.1016/j.ab.2017.08.004⟩
Journal articles hal-02046314v1

Probing the cholinergic system to understand neurodegenerative diseases

Pierre-Yves Renard , Ludovic Jean
Future Medicinal Chemistry, 2017, 9 (2), pp.131-133. ⟨10.4155/fmc-2016-0213⟩
Journal articles hal-02046305v1
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Azo-based Fluorogenic Probes for Biosensing and Bioimaging: Recent Advances and Upcoming Challenges

Arnaud Chevalier , Pierre-Yves Renard , Anthony Romieu
Chemistry - An Asian Journal, 2017, 12 (16), pp.2008-2028. ⟨10.1002/asia.201700682⟩
Journal articles hal-01562215v1
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On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach

Thomas Driant , Florian Nachon , Cyril Ollivier , Pierre-Yves Renard , Etienne Derat
ChemBioChem, 2017, 18 (7), pp.666-675. ⟨10.1002/cbic.201600646⟩
Journal articles hal-01644385v1

Metal-free oxidative ring contraction of benzodiazepinones: an entry to quinoxalinones

Hasan Mtiraoui , Kévin Renault , Morgane Sanselme , Moncef Msaddek , Pierre-Yves Renard
Organic & Biomolecular Chemistry, 2017, 15 (14), pp.3060-3068. ⟨10.1039/C7OB00205J⟩
Journal articles hal-02329806v1

An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice

André-Guilhem Calas , José Dias , Catherine Rousseau , Mélanie Arboléas , Mélanie Touvrey-Loiodice
Chemico-Biological Interactions, 2017, 267 (1), pp.11-16. ⟨10.1016/j.cbi.2016.03.009⟩
Journal articles hal-02046266v1

Selective and sensitive near‐infrared fluorescent probe for acetylcholinesterase imaging [abstract]

Pierre-Yves Renard , Ludovic Jean
Journal of Neurochemistry, 2017, 142 (S2), pp.188-225. ⟨10.1111/jnc.13925⟩
Journal articles hal-02329887v1

5-Alkoxyoxazole –A Versatile Building Block in (Bio)organic Synthesis

Laurie-Anne Jouanno , Kévin Renault , Cyrille Sabot , Pierre-Yves Renard
European Journal of Organic Chemistry, 2016, 2016 (20), pp.3264-3281. ⟨10.1002/ejoc.201600127⟩
Journal articles hal-02046218v1

A selective and sensitive near-infrared fluorescent probe for acetylcholinesterase imaging

Sovy Chao , Eric Krejci , Véronique Bernard , Jacqueline Leroy , Ludovic Jean
Chemical Communications, 2016, 52 (77), pp.11599-11602. ⟨10.1039/c6cc05936h⟩
Journal articles hal-03013508v1

Readily functionalizable phosphonium-tagged fluorescent coumarins for enhanced detection of conjugates by mass spectrometry

Antoine Lizzul-Jurse , Laëtitia Bailly , Marie Hubert-Roux , Carlos Afonso , Pierre-Yves Renard
Organic & Biomolecular Chemistry, 2016, 14 (32), pp.7777-7791. ⟨10.1039/c6ob01080f⟩
Journal articles hal-02046223v1

Solution and solid-state fluorescence of 2-(2′-hydroxyphenyl)-1,5-benzodiazepin-2-one (HBD) borate complexes

Hasan Mtiraoui , Rafik Gharbi , Moncef Msaddek , Yann Bretonnière , Chantal Andraud
RSC Advances, 2016, 6 (89), pp.86352-86360. ⟨10.1039/C6RA19246G⟩
Journal articles hal-01526238v1

Fluorogenic Behaviour of the Hetero-Diels–Alder Ligation of 5-Alkoxyoxazoles with Maleimides and their Applications

Kévin Renault , Laurie-Anne Jouanno , Antoine Lizzul-Jurse , Pierre-Yves Renard , Cyrille Sabot
Chemistry - A European Journal, 2016, 22 (51), pp.18522-18531. ⟨10.1002/chem.201603617⟩
Journal articles hal-02046236v1

Synthesis and in vitro evaluation of donepezil-based reactivators and analogues for nerve agent-inhibited human acetylcholinesterase

Julien Renou , José Dias , Guillaume Mercey , Tristan Verdelet , Catherine Rousseau
RSC Advances, 2016, 6 (22), pp.17929-17940. ⟨10.1039/c5ra25477a⟩
Journal articles hal-02046237v1

Synthesis and photophysical properties of iron-carbonyl complex–coumarin conjugates as potential bimodal IR–fluorescent probes

Paulina C. Glowacka , Nicolas Maindron , G. Richard Stephenson , Anthony Romieu , Pierre-Yves Renard
Tetrahedron Letters, 2016, 57 (45), pp.4991-4996. ⟨10.1016/j.tetlet.2016.09.091⟩
Journal articles hal-01428754v1

Improved Access to Huprine Derivatives Functionalized at Position 9

Killian Oukoloff , Sovy Chao , Monika Cieslikiewicz-Bouet , Romain Mougeot , Ludovic Jean
European Journal of Organic Chemistry, 2016, 2016 (7), pp.1337-1343. ⟨10.1002/ejoc.201501433⟩
Journal articles hal-02046230v1

1,5-Benzodiazepin-2-ones: Investigation of a Family of Photoluminescent Materials

Hasan Mtiraoui , Rafik Gharbi , Moncef Msaddek , Yann Bretonnière , Chantal Andraud
Journal of Organic Chemistry, 2016, 81 (11), pp.4720-4727. ⟨10.1021/acs.joc.6b00627⟩
Journal articles hal-01526233v1

A FRET-​based probe for fluorescence sensing of sulfide​/sulfite analytes, using a novel long-​wavelength water-​soluble 7-​hydroxycoumarin as reporter fluorophore

Benoît Roubinet , Laëtitia Bailly , Emilie Petit , Pierre-Yves Renard , Anthony Romieu
Tetrahedron Letters, 2015, 56 (8), pp.1015-1019. ⟨10.1016/j.tetlet.2015.01.042⟩
Journal articles hal-01150270v1

Azobenzene-caged sulforhodamine dyes: A novel class of 'turn-on' reactive probes for hypoxic tumor cell imaging

Arnaud Chevalier , Wen Piao , Kenjiro Hanaoka , Tetsuo Nagano , Pierre-Yves Renard
Methods and Applications in Fluorescence, 2015, 3 (4), pp.044004. ⟨10.1088/2050-6120/3/4/044004⟩
Journal articles hal-02046143v1

Rapid Synthesis of Unsymmetrical Sulforhodamines Through Nucleophilic Amination of a Monobrominated Sulfoxanthene Dye

Arnaud Chevalier , Kévin Renault , Frederic Boschetti , Pierre-Yves Renard , Anthony Romieu
European Journal of Organic Chemistry, 2015, 2015 (1), pp.152-165. ⟨10.1002/ejoc.201403165⟩
Journal articles hal-01150274v1

Rational Design of Latent Fluorophores from Water-​Soluble Hydroxyphenyltriazine Dyes Suitable for Lipase Sensing

Alicia Jacquemet , Sandra Rihn , Gilles Ulrich , Pierre-Yves Renard , Anthony Romieu
European Journal of Organic Chemistry, 2015, 2015 (8), pp.1664-1669. ⟨10.1002/ejoc.201500047⟩
Journal articles hal-01150275v1

PET and SPECT radiotracers for Alzheimer's disease

Killian Oukoloff , Monika Cieslikiewicz-Bouet , Sovy Chao , Emilie da Costa Branquinho , C. Bouteiller
Current Medicinal Chemistry, 2015, 22 (28), pp.3278-3304. ⟨10.2174/0929867322666150805094645⟩
Journal articles hal-02046165v1

Multi-target directed ligands: Electrophysiological characterization of an anticholinesterase inhibitor coupled to an agonist of α7 nicotinic acetylcholine receptor

Rómulo Aráoz , Monika Bouet , Manuela Bartolini , Nicolas Coquelle , Jacques-Philippe Colletier
Biochemical Pharmacology, 2015, 97 (4), pp.621. ⟨10.1016/j.bcp.2015.08.006⟩
Journal articles hal-02329901v1

New insights into the kinetic target-guided synthesis of protein ligands

E. Oueis , Cyrille Sabot , Pierre-Yves Renard
Chemical Communications, 2015, 51 (61), pp.12158-12169. ⟨10.1039/c5cc04183j⟩
Journal articles hal-02046164v1

New 3-(Heteroaryl)-2-iminocoumarin-based Borate Complexes: Synthesis, Photophysical Properties, and Rational Functionalization for Biosensing/Biolabeling Applications

Benoît Roubinet , Cédrik Massif , Mathieu Moreau , F. Boschetti , Gilles Ulrich
Chemistry - A European Journal, 2015, 21 (41), pp.14589-14601. ⟨10.1002/chem.201502126⟩
Journal articles hal-02046171v1

Fast-Responsive Nitroso-Based Turn-On Probe for Hydrogen Sulfide

Kévin Renault , Cyrille Sabot , Pierre-Yves Renard
European Journal of Organic Chemistry, 2015, 2015 (36), pp.7992-7996. ⟨10.1002/ejoc.201501140⟩
Journal articles hal-02046170v1

A novel bio-orthogonal cross-linker for improved protein/protein interaction analysis

Catherine Nury , Virginie Redeker , Sébastien Dautrey , Anthony Romieu , Guillaume van Der Rest
Analytical Chemistry, 2015, 87 (3), pp.1853-1860. ⟨10.1021/ac503892c⟩
Journal articles hal-01144840v1

A Synthetic Route to 3-​(Heteroaryl)​-​7-​hydroxycoumarins Designed for Biosensing Applications

Benoît Roubinet , Arnaud Chevalier , Pierre-Yves Renard , Anthony Romieu
European Journal of Organic Chemistry, 2015, 2015 (1), pp.166-182. ⟨10.1002/ejoc.201403215⟩
Journal articles hal-01150273v1

Synthetic Route to Rare Isoindolones Derivatives

Killian Oukoloff , Frederic Buron , Sylvain Routier , Ludovic Jean , Pierre-Yves Renard
European Journal of Organic Chemistry, 2015, 2015 (11), pp.2450-2456. ⟨10.1002/ejoc.201403649⟩
Journal articles hal-01150276v1

Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1

Lucie Aliouane , Sovy Chao , Brizuela Leyre , Emmanuel Pfund , Cuvillier Olivier
Bioorganic and Medicinal Chemistry, 2014, 22 (17), pp.4955-4960. ⟨10.1016/j.bmc.2014.06.038⟩
Journal articles hal-01063240v1

Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase

Maria Kliachyna , Gianluca Santoni , Valentin Nussbaum , Julien Renou , Benoît Sanson
European Journal of Medicinal Chemistry, 2014, 78, pp.455-467. ⟨10.1016/j.ejmech.2014.03.044⟩
Journal articles hal-01131268v1

Tryptoline-​3-​hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterase

Julien Renou , Melanie Loiodice , Melanie Arboleas , Rachid Baati , Ludovic Jean
Chemical Communications, 2014, 50 (30), pp.3947-3950. ⟨10.1039/C4CC00561A⟩
Journal articles hal-01150284v1
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Biochemical Characterization of a Caspase-3 Far-red Fluorescent Probe for Non-invasive Optical Imaging of Neuronal Apoptosis

Valérie Jolivel , Sébastien Arthaud , Béatrice Botia , Christophe Portal , Bruno Delest
Journal of Molecular Neuroscience, 2014, 54 (3), pp.451-462. ⟨10.1007/s12031-014-0325-4⟩
Journal articles hal-01196843v1

Straightforward synthesis of bioconjugatable azo dyes. Part 2: Black Hole Quencher-​2 (BHQ-​2) and BlackBerry Quencher 650 (BBQ-​650) scaffolds

Arnaud Chevalier , Pierre-Yves Renard , Anthony Romieu
Tetrahedron Letters, 2014, 50 (55), pp.6764-6768. ⟨10.1016/j.tetlet.2014.10.054⟩
Journal articles hal-01150282v1

Straightforward Access to Water-​Soluble Unsymmetrical Sulfoxanthene Dyes: Application to the Preparation of Far-​Red Fluorescent Dyes with Large Stokes' Shifts

Arnaud Chevalier , Pierre-Yves Renard , Anthony Romieu
Chemistry - A European Journal, 2014, 20 (27), pp.8330-8337. ⟨10.1002/chem.201402306⟩
Journal articles hal-01150280v1

Straightforward synthesis of bioconjugatable azo dyes. Part 1: Black Hole Quencher-​1 (BHQ-​1) scaffold

Arnaud Chevalier , Pierre-Yves Renard , Anthony Romieu
Tetrahedron Letters, 2014, 55 (50), pp.6759-6763. ⟨10.1016/j.tetlet.2014.10.053⟩
Journal articles hal-01150281v1

First enzymatic hydrolysis/thio-Michael addition cascade route to synthesis of AChE inhibitors.

Emilia Oueis , Florian Nachon , Cyrille Sabot , Pierre-Yves Renard
Chemical Communications, 2014, 50 (16), pp.2043-2045. ⟨10.1039/c3cc48871c⟩
Journal articles hal-00996567v1

Reaction site-driven regioselective synthesis of AChE inhibitors

Emilia Oueis , Gianluca Santoni , Cyril Ronco , Olga A. Syzgantseva , Vincent Tognetti
Organic & Biomolecular Chemistry, 2014, 12 (1), pp.156-161. ⟨10.1039/C3OB42109K⟩
Journal articles hal-02335933v1

Azo-Sulforhodamine Dyes: A Novel Class of Broad Spectrum Dark Quenchers

Arnaud Chevalier , Pierre-Yves Renard , Anthony Romieu
Organic Letters, 2014, 16 (15), pp.3946-3949. ⟨10.1021/ol501753b⟩
Journal articles hal-02335871v1

Metal-Free Decarboxylative Hetero-Diels-Alder Synthesis of 3-Hydroxypyridines: A Rapid Access to N-Fused Bicyclic Hydroxypiperidine Scaffolds.

Laurie-Anne Jouanno , Vincent Di Mascio , Vincent Tognetti , Laurent Joubert , Cyrille Sabot
Journal of Organic Chemistry, 2014, 79 (3), pp.1303-1319. ⟨10.1021/jo402729a⟩
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Kondrat'eva ligation: Diels-Alder-based irreversible reaction for bioconjugation

Laurie-Anne Jouanno , Arnaud Chevalier , Nawal Sekkat , Nicolas Perzo , Hélène Castel
Journal of Organic Chemistry, 2014, 79 (21), pp.10353-10366. ⟨10.1021/jo501972m⟩
Journal articles hal-01144842v1

New insights into the water-​solubilization of thiol-​sensitive fluorogenic probes based on long-​wavelength 7-​hydroxycoumarin scaffolds

Benoît Roubinet , Pierre-Yves Renard , Anthony Romieu
Dyes and Pigments, 2014, 110, pp.270-284. ⟨10.1016/j.dyepig.2014.02.004⟩
Journal articles hal-01150279v1

Synthesis, biological evaluation, and in vivo imaging of the first camptothecin-fluorescein conjugate.

Arnaud Chevalier , Martine Dubois , Vadim Le Joncour , Sébastien Dautrey , Céline Lecointre
Bioconjugate Chemistry, 2013, 24 (7), pp.1119-1133. ⟨10.1021/bc3005304⟩
Journal articles hal-00996547v1

Strategies for the selection of catalytic antibodies against organophosphorus nerve agents.

Ivan Smirnov , Alexey Belogurov , Alain Friboulet , Patrick Masson , Alexander Gabibov
Chemico-Biological Interactions, 2013, 203 (1), pp.196-201. ⟨10.1016/j.cbi.2012.10.011⟩
Journal articles hal-00996534v1

A novel sulfonated prosthetic group for [18F]-radiolabelling and imparting water solubility of biomolecules and cyanine fluorophores.

Thomas Priem , Cédric Bouteiller , Davide Camporese , Xavier Brune , Julie Hardouin
Organic & Biomolecular Chemistry, 2013, 11 (3), pp.469-479. ⟨10.1039/c2ob26659h⟩
Journal articles hal-00996532v1

Universal dark quencher based on "clicked" spectrally distinct azo dyes.

Arnaud Chevalier , Julie Hardouin , Pierre-Yves Renard , Anthony Romieu
Organic Letters, 2013, 15 (23), pp.6082-6085. ⟨10.1021/ol402972y⟩
Journal articles hal-00996556v1

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.

Florian Nachon , Eugénie Carletti , Cyril Ronco , Marie Trovaslet , Yvain Nicolet
Biochemical Journal, 2013, 453 (3), pp.393-399. ⟨10.1042/BJ20130013⟩
Journal articles hal-00996550v1

The first comparative study of the ability of different hydrophilic groups to water-solubilize fluorescent BODIPY dyes

Anthony Romieu , Cédrik Massif , Sandra Rihn , Gilles Ulrich , Raymond Ziessel
New Journal of Chemistry, 2013, 37 (4), pp.1016-1027. ⟨10.1039/C3NJ41093E⟩
Journal articles hal-01015523v1

Bioconjugatable azo-based dark-quencher dyes: synthesis and application to protease-activatable far-red fluorescent probes.

Arnaud Chevalier , Cédrik Massif , Pierre-Yves Renard , Anthony Romieu
Chemistry - A European Journal, 2013, 19 (5), pp.1686-1699. ⟨10.1002/chem.201203427⟩
Journal articles hal-00996530v1

Radiosynthesis and in vivo evaluation of fluorinated huprine derivates as PET radiotracers of acetylcholinesterase

Emilie da Costa Branquinho , Guillaume Becker , Cédric Bouteiller , Ludovic Jean , Pierre-Yves Renard
Nuclear Medicine and Biology, 2013, 40 (4), pp.554-560. ⟨10.1016/j.nucmedbio.2013.02.004⟩
Journal articles hal-00847401v1

Thermally controlled decarboxylative [4 + 2] cycloaddition between alkoxyoxazoles and acrylic acid: expedient access to 3-hydroxypyridines.

Laurie-Anne Jouanno , Vincent Tognetti , Laurent Joubert , Cyrille Sabot , Pierre-Yves Renard
Organic Letters, 2013, 15 (10), pp.2530-2533. ⟨10.1021/ol4010195⟩
Journal articles hal-00996416v1

The first latent green fluorophores for the detection of azoreductase activity in bacterial cultures.

Arnaud Chevalier , Claire Mercier , Laura Saurel , Sylvain Orenga , Pierre-Yves Renard
Chemical Communications, 2013, 49 (78), pp.8815-8817. ⟨10.1039/c3cc44798g⟩
Journal articles hal-00996553v1

Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents.

Julien Renou , Guillaume Mercey , Tristan Verdelet , Emilia Păunescu , Emilie Gillon
Chemico-Biological Interactions, 2013, 203 (1), pp.81-84. ⟨10.1016/j.cbi.2012.09.023⟩
Journal articles hal-00996535v1

The first "ready-to-use" benzene-based heterotrifunctional cross-linker for multiple bioconjugation.

Guillaume Viault , Sébastien Dautrey , Nicolas Maindron , Julie Hardouin , Pierre-Yves Renard
Organic & Biomolecular Chemistry, 2013, 11 (16), pp.2693-2705. ⟨10.1039/c3ob40086g⟩
Journal articles hal-00996541v1

Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography.

Cyril Ronco , Eugénie Carletti , Jacques-Philippe Colletier , Martin Weik , Florian Nachon
ChemMedChem, 2012, 7 (3), pp.400-405. ⟨10.1002/cmdc.201100438⟩
Journal articles hal-00996475v1

Synthesis and reactivity of a bis-sultone cross-linker for peptide conjugation and [18F]-radiolabelling via unusual "double click" approach.

Thomas Priem , Cédric Bouteiller , David Camporese , Anthony Romieu , Pierre-Yves Renard
Organic & Biomolecular Chemistry, 2012, 10 (5), pp.1068-1078. ⟨10.1039/c1ob06600e⟩
Journal articles hal-00996479v1

Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents

Guillaume Mercey , Tristan Verdelet , Julien Renou , Maria Kliachyna , Rachid Baati
Accounts of Chemical Research, 2012, 45 (5), pp.756-766. ⟨10.1021/ar2002864⟩
Journal articles hal-01015972v1

Expeditious microwave-assisted synthesis of 5-alkoxyoxazoles from α-triflyloxy esters and nitriles.

Laurie-Anne Jouanno , Cyrille Sabot , Pierre-Yves Renard
Journal of Organic Chemistry, 2012, 77 (19), pp.8549-8555. ⟨10.1021/jo301527t⟩
Journal articles hal-00996502v1

Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase.

Guillaume Mercey , Julien Renou , Tristan Verdelet , Maria Kliachyna , Rachid Baati
Journal of Medicinal Chemistry, 2012, 55 (23), pp.10791-10795. ⟨10.1021/jm3015519⟩
Journal articles hal-00996512v1

Water-soluble red-emitting distyryl-borondipyrromethene (BODIPY) dyes for biolabeling

Song-Lin Niu , Cédrik Massif , Gilles Ulrich , Pierre-Yves Renard , Anthony Romieu
Chemistry - A European Journal, 2012, 18 (23), pp.7229-7242. ⟨10.1002/chem.201103613⟩
Journal articles hal-00996473v1

New insights into the water-solubilisation of fluorophores by post-synthetic "click" and Sonogashira reactions

Cédrik Massif , Sébastien Dautrey , Alexandre Haefele , Raymond Ziessel , Pierre-Yves Renard
Organic & Biomolecular Chemistry, 2012, 10 (22), pp.4330-4336. ⟨10.1039/c2ob25428j⟩
Journal articles hal-00996469v1

Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure.

Xavier Brazzolotto , Marielle Wandhammer , Cyril Ronco , Marie Trovaslet , Ludovic Jean
FEBS Journal, 2012, 279 (16), pp.2905-2916. ⟨10.1111/j.1742-4658.2012.08672.x⟩
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Synthesis of polysubstituted 3-hydroxypyridines via the revisited hetero-Diels-Alder reaction of 5-alkoxyoxazoles with dienophiles.

Cyrille Sabot , Emilia Oueis , Xavier Brune , Pierre-Yves Renard
Chemical Communications, 2012, 48 (5), pp.768-770. ⟨10.1039/c1cc16562c⟩
Journal articles hal-00996467v1

Screening of new huprines--inhibitors of acetylcholinesterases by electrospray ionization ion trap mass spectrometry

Anna Ziemianin , Cyril Ronco , Romain Dolé , Ludovic Jean , Pierre-Yves Renard
Journal of Pharmaceutical and Biomedical Analysis, 2012, 70, pp.1-5. ⟨10.1016/j.jpba.2012.01.038⟩
Journal articles hal-00996397v1

A novel and unusually long-lived chemiluminophore based on the 7-hydroxycoumarin scaffold.

Jan Kočí , Virgile Grandclaude , Marc Massonneau , Jean-Alexandre Richard , Anthony Romieu
Chemical Communications, 2011, 47 (23), pp.6713-6715. ⟨10.1039/c1cc11919b⟩
Journal articles hal-00991904v1
Image document

In Vitro and Ex Vivo Evaluation of Smart Infra-Red Fluorescent Caspase-3 Probes for Molecular Imaging of Cardiovascular Apoptosis

Manuelle Debunne , Christophe Portal , Bruno Delest , Ebba Brakenhielm , Françoise Lallemand
International Journal of Molecular Imaging, 2011, 2011, pp.413290. ⟨10.1155/2011/413290⟩
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Synthesis and luminescence properties of new red-shifted absorption lanthanide(III) chelates suitable for peptide and protein labelling.

Nicolas Maindron , Séverine Poupart , Maxime Hamon , Jean-Baptiste Langlois , Nelly Plé
Organic & Biomolecular Chemistry, 2011, 9 (7), pp.2357-2370. ⟨10.1039/c0ob00832j⟩
Journal articles hal-00991910v1

Synthesis of difluoromethylphosphonamidates by direct addition of amine

Lucie Aliouane , Baptiste Rigaud , Emmanuel Pfund , Ludovic Jean , Pierre-Yves Renard
Tetrahedron Letters, 2011, 52 (28), pp.3681-3685. ⟨10.1016/j.tetlet.2011.05.034⟩
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Palladium-Catalyzed Preparation of N-Alkylated Tacrine and Huprine Compounds

Cyril Ronco , Ludovic Jean , Hakim Outaabout , Pierre-Yves Renard
European Journal of Organic Chemistry, 2011, 2011 (2), pp.302-310. ⟨10.1002/ejoc.201001158⟩
Journal articles hal-01017284v1

The first metal-free water-soluble cryptophane-111.

Ténin Traoré , Guillaume Clavé , Léa Delacour , Naoko Kotera , Pierre-Yves Renard
Chemical Communications, 2011, 47 (34), pp.9702-9704. ⟨10.1039/c1cc13378k⟩
Journal articles hal-00991921v1

Optimized strategies to synthesize β-cyclodextrin-oxime conjugates as a new generation of organophosphate scavengers.

Romain Le Provost , Timo Wille , Ludivine Louise , Nicolas Masurier , Susanne Müller
Organic & Biomolecular Chemistry, 2011, 9 (8), pp.3026-3032. ⟨10.1039/c0ob00931h⟩
Journal articles hal-00991907v1

Water-solubilisation and bio-conjugation of a red-emitting BODIPY marker

Song Lin Niu , Cédrik Massif , Gilles Ulrich , Raymond Ziessel , Pierre-Yves Renard
Organic & Biomolecular Chemistry, 2011, 9 (1), pp.66-69. ⟨10.1039/c0ob00693a⟩
Journal articles hal-00991914v1

Straightforward and efficient synthesis of 3-benzyloxy-4-bromopicolinate ester and 3-benzyloxy-5-bromopicolinate ester, common building blocks for pharmaceuticals and agrochemicals

Tristan Verdelet , Guillaume Mercey , Nobi Correa , Ludovic Jean , Pierre-Yves Renard
Tetrahedron, 2011, 67 (45), pp.8757-8762. ⟨10.1016/j.tet.2011.09.024⟩
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Design, synthesis and evaluation of new alpha-nucleophiles for the hydrolysis of organophosphorus nerve agents: application to the reactivation of phosphorylated acetylcholinesterase

Géraldine Saint-André , Maria Kliachyna , Sanjeevarao Kodepelly , Ludivine Louise-Leriche , Emilie Gillon
Tetrahedron, 2011, 67 (34), pp.6352-6361. ⟨10.1016/j.tet.2011.05.130⟩
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New huprine derivatives functionalized at position 9 as highly potent acetylcholinesterase inhibitors.

Cyril Ronco , Richard Foucault , Emilie Gillon , Pierre Bohn , Florian Nachon
ChemMedChem, 2011, 6 (5), pp.876-888. ⟨10.1002/cmdc.201000523⟩
Journal articles hal-00991920v1

A versatile access to new halogenated 7-azidocoumarins for photoaffinity labeling: Synthesis and photophysical properties

Emilia Paunescu , Ludivine Louise , Ludovic Jean , Anthony Romieu , Pierre-Yves Renard
Dyes and Pigments, 2011, 91 (3), pp.427-434. ⟨10.1016/j.dyepig.2011.05.008⟩
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N-Fmoc-α-sulfo-β-alanine: a versatile building block for the water solubilisation of chromophores and fluorophores by solid-phase strategy.

Anthony Romieu , Thomas Bruckdorfer , Guillaume Clavé , Virgile Grandclaude , Cédrik Massif
Organic & Biomolecular Chemistry, 2011, 9 (15), pp.5337-5342. ⟨10.1039/c1ob05730h⟩
Journal articles hal-00991917v1

First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.

Guillaume Mercey , Tristan Verdelet , Géraldine Saint-André , Emilie Gillon , Alain Wagner
Chemical Communications, 2011, 47 (18), pp.5295-5297. ⟨10.1039/c1cc10787a⟩
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A universal and ready-to-use heterotrifunctional cross-linking reagent for facile synthetic access to sophisticated bioconjugates.

Guillaume Clavé , Hervé Volland , Mélanie Flaender , Didier Gasparutto , Anthony Romieu
Organic & Biomolecular Chemistry, 2010, 8 (19), pp.4329-4345. ⟨10.1039/c0ob00133c⟩
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A comparative study of the self-immolation of para-aminobenzylalcohol and hemithioaminal-based linkers in the context of protease-sensitive fluorogenic probes.

Yves Meyer , Jean-Alexandre Richard , Bruno Delest , Pauline Noack , Pierre-Yves Renard
Organic & Biomolecular Chemistry, 2010, 8 (8), pp.1777-1780. ⟨10.1039/b926316k⟩
Journal articles hal-00991894v1

Facile and rapid access to linear and truncated microcystin analogues for the implementation of immunoassays.

G. Clavé , C. Ronco , H. Boutal , N. Kreich , H. Volland
Organic & Biomolecular Chemistry, 2010, 8 (3), pp.676-690. ⟨10.1039/b920193a⟩
Journal articles hal-00991885v1

Water solubilization of xanthene dyes by post-synthetic sulfonation in organic media

Anthony Romieu , Delphine Tavernier-Lohr , S Pellet-Rostaing , Marc Lemaire , Pierre-Yves Renard
Tetrahedron Letters, 2010, 51 (25), pp.3304-3308. ⟨10.1016/j.tetlet.2010.04.080⟩
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A HTS assay for the detection of organophosphorus nerve agent scavengers.

Ludivine Louise-Leriche , Emilia Paunescu , Géraldine Saint-André , Rachid Baati , Anthony Romieu
Chemistry - A European Journal, 2010, 16 (11), pp.3510-3523. ⟨10.1002/chem.200902986⟩
Journal articles hal-00991892v1

Improved synthetic pathway for the derivatization of huprine scaffold

Cyril Ronco , Ludovic Jean , Pierre-Yves Renard
Tetrahedron, 2010, 66 (37), pp.7399-7404. ⟨10.1016/j.tet.2010.07.021⟩
Journal articles hal-01019278v1

Additions and Corrections

Pierre-Yves Renard
Organic & Biomolecular Chemistry, 2009, 7 (24), pp.5271. ⟨10.1039/b922697b⟩
Journal articles hal-03808190v1

Synthesis and structure–activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors

Cyril Ronco , Geoffroy Sorin , Florian Nachon , Richard Foucault , Ludovic Jean
Bioorganic and Medicinal Chemistry Letters, 2009, 17 (13), pp.4523-4536. ⟨10.1016/j.bmc.2009.05.005⟩
Journal articles hal-03808202v1

Self-cleavable chemiluminescent probes suitable for protease sensing

Jean-Alexandre Richard , Ludovic Jean , Caroline Schenkels , Marc Massonneau , Anthony Romieu
Organic & Biomolecular Chemistry, 2009, 7 (14), pp.2941. ⟨10.1039/b905725k⟩
Journal articles hal-03808199v1

Aryldithioethyloxycarbonyl(Ardec) : a new family of aminoe protecting groups removable under mild reducing conditions and their applications to peptide synthesis.

M. Lapeyre , Jérôme Leprince , M. Massonneau , Hassan Oulyadi , Pierre-Yves Renard
Chemistry - A European Journal, 2006, 12, pp.3655-3671
Journal articles hal-00023718v1

Aryldithioethyloxycarbonyl (Ardec): A New Family of Amine Protecting Groups Removable under Mild Reducing Conditions and Their Applications to Peptide Synthesis

Milaine Lapeyre , Jérôme Leprince , Marc Massonneau , Hassan Oulyadi , Pierre-Yves Renard
Chemistry - A European Journal, 2006, 12 (13), pp.3655-3671. ⟨10.1002/chem.200501538⟩
Journal articles hal-01962803v1

Lewis Acid Catalyzed Room-Temperature Michaelis–Arbuzov Rearrangement

Pierre-Yves Renard , Philippe Vayron , Eric Leclerc , Alain Valleix , Charles Mioskowski
Angewandte Chemie International Edition, 2003, 42 (21), pp.2389-2392. ⟨10.1002/anie.200250270⟩
Journal articles hal-02345149v1

Stereoselective access to polyfunctionalized decalins

Cyrille Poirel , P.Y. Renard , J.Y. Lallemand
Tetrahedron Letters, 1994, 35 (35), pp.6485-6488
Journal articles hal-02710197v1

Multi-target drug Ligands design and synthesis for Alzheimer disease backed by X-ray crystal analyses

Pierre-Yves Renard
Annual Conference of AnalytiX (7, 2019), Nov 2019, Berlin, Germany
Conference papers hal-02404227v1

Sondes pro-fluorescentes et chémiluminescentes pour la détection d'analyses d'intérêt biologique

Pierre-Yves Renard
Séminaire national, Institut Brestois Santé Agro Matière (IBSAM), May 2019, Brest, France
Conference papers hal-02404291v1

Overview of 3-hydroxy-pyridindaldoxime based reactivators

Pierre-Yves Renard
International workshop on nerve agents, North Atlantic Treaty Organisation (NATO), Nov 2018, Paris, France
Conference papers hal-02403935v1

Sondes fluorogéniques pour la détection d'activités enzymatiques et d'analytes d'intérêt biologiques

Pierre-Yves Renard
Séminaire national, Institut des biomolécules Max Mousseron (IBMM, UMR 5247), Oct 2018, Montpellier, France
Conference papers hal-02393849v1

Méthode de criblage : identification de catalyseurs de la réaction de Diels-Alder

Cyrille Sabot , Laura Nogueira de Faria Cardoso , Pierre-Yves Renard , Wadih Ghattas , Jean-Pierre Mahy
Journée scientifique du LabEx Chimie des Architectures Moléculaires Multifonctionnelles et des Matériaux (CHARMMMAT, 6, 2018)), Jun 2018, Cachan, France
Conference papers hal-02372510v1

Méthode de criblage : identification de catalyseurs de la réaction de Diels-Alder

Cyrille Sabot , Laura Nogueira de Faria Cardoso , Pierre-Yves Renard , Wadih Ghattas , Jean-Pierre Mahy
Journée scientifique du LabEx Chimie des Architectures Moléculaires Multifonctionnelles et des Matériaux (CHARMMMAT, 6, 2018)), Jun 2018, Cachan, France
Conference papers hal-03098307v1

Pro-fluorescent and chemiluminescent probes for enzymatic activities detection

Pierre-Yves Renard
Séminaire national, Laboratoire des biomolécules (LBM, UMR 7203), May 2018, Paris, France
Conference papers hal-02393089v1

Fluorogenic Behaviour of the Hetero-Diels-Alder Ligation of 5-Alkoxyoxazoles with Maleimides and their Applications

Pierre-Yves Renard
International Caparica Conference on Chromogenic and Emissive Materials (3, 2018), Jun 2018, Lisbonne, Portugal
Conference papers hal-02388673v1

Réactions de ligation fluorogéniques

Pierre-Yves Renard
Journées scientifiques de chémobiologie, Nov 2018, Lille, France
Conference papers hal-02389306v1

Chimiluminescence in vivo

Pierre-Yves Renard
Rencontre ChiMi. Fluorescence : de la paillasse à l'utilisation clinique, Jan 2018, Dijon, France
Conference papers hal-02395824v1

Novel centrally active antidote for intoxication by sarin and VX nerve agents

T. Zorbaz , M. Katalinic , A. Zandona , Anissa Braïki , Ludovic Jean
Congress of the Federation-of-European-Biochemical-Societies (FEBS) on From Molecules to Cells and Back (42, 2017), Sep 2017, Jérusalem, Israel. pp.242, ⟨10.1111/febs.14174⟩
Conference papers hal-02024992v1

The effects of organophosphorus compounds and novel antidotes on human neuronal cells

T. Zorbaz , M. Katalinic , I. Pavicic , Anissa Braïki , J. Renou
International Symposium on Cholinergic Mechanisms (ISCM, 15, 2016), Oct 2016, Marseille, France. pp.224-225
Conference papers hal-02024991v1

Heterotrifunctionnal linkers for bioconjugate reactions

Pierre-Yves Renard
The Missing link biologically driven ligation of carbohydrates and proteins, Jun 2016, Kiel, Germany
Conference papers hal-02389804v1

Water soluble unsymmetrical sulfoxanthene dyes - access to a novel class of broad spectrum dark quenchers

Pierre-Yves Renard
International Caparica Conference on Chromogenic and Emissive Materials (2, 2016), Sep 2016, Lisbonne, Portugal
Conference papers hal-02388670v1

Selective and sensitive near-infrared fluorescent probe for acetylcholinesterase imaging

Sovy Chao , Ludovic Jean , E. Krejci , Pierre-Yves Renard
International Symposium on Cholinergic Mechanisms (ISCM, 15, 2017), Oct 2016, Marseille, France. pp.209, ⟨10.1111/jnc.13925⟩
Conference papers hal-02024977v1

Hupresin, a new affinity resin to purify butyrylcholinesterase

E. David , C. Ronco , Ludovic Jean , X. Brazzolotto , F. Nachon
International Symposium on Cholinergic Mechanisms (ISCM, 15, 2017), Oct 2016, Marseille, France. pp.210, ⟨10.1111/jnc.13925⟩
Conference papers hal-02024979v1

Toward an innovative treatment of Alzheimer's disease: Synthesis and evaluation of multi-target directed ligands (MTDLs) targeting acetylcholinesterase (AChE) and alpha7 nicotinic acetylchloline receptors (alpha7 nAChRs)

Monika Cieslikiewicz-Bouet , Sovy Chao , Ludovic Jean , R. Araoz , D. Servent
International Symposium on Cholinergic Mechanisms (ISCM, 15, 2016), Oct 2016, Marseille, France. pp.209-210
Conference papers hal-02024978v1

Pro-fluorescent and chemiluminescent probes for enzymatic activities detection

Pierre-Yves Renard
Séminaire national, Institut de chimie de Nice (ICN, UMR 7272), Mar 2016, Nice, France
Conference papers hal-02393073v1

New oximes for OP poisoned cholinesterases reactivation

Pierre-Yves Renard
International workshop on chemical warfare agents: toxicity, emergency response and medical countermeasures, Sep 2016, Paris, France
Conference papers hal-02388800v1

Exemples d'utilisation de sondes fluorescentes pour détecter l'évolution et les impacts de traitements antitumoraux

Pierre-Yves Renard
Journée de présentation et d´échanges Chimie, Biologie et Cancer dans l´inter-région Nord-Ouest, Apr 2016, Amiens, France
Conference papers hal-02395831v1

L'acétylcholinestérase

Pierre-Yves Renard
Séminaire industriel, Servier, Mar 2016, Croissy-sur-Seine, France
Conference papers hal-02391648v1

Insights on two in situ click chemistry reactions for the synthesis of AChE inhibitors

E. Oueis , Ronco C. , F. Nachon , Cyrille Sabot , Ludovic Jean
International Meeting on Cholinesterases - Sixth International Conference on Paraoxonases (12, 2015), Sep 2015, Elche, Spain
Conference papers hal-02379142v1

L'acétylcholinestérase : une enzyme modèle pour le chimiste bio-organicien

Pierre-Yves Renard
Séminaire national, Institut de chimie moléculaire de l'Université de Bourgogne (ICMUB, UMR 6302), Apr 2015, Dijon, France
Conference papers hal-02391659v1

Dynamic mapping of acetylcholinesterase for structural-dynamics based reactivator design

G. Santoni , E. de La Mora , J.-P. Colletier , Ludovic Jean , Y. Xu
12th International Meeting on Cholinesterases, Sep 2015, Elche, Spain
Conference papers hal-02024984v1

Evaluation of three novel hydroxypicolinaldehyde oximes as efficient uncharged reactivators of VX-inhibited human acetylcholinesterase

Z. Kovarik , M. Katalinic , Ludovic Jean , Pierre-Yves Renard , Renou J.
FEBS-EMBO Anniversary Conference, Federation of European Biochemical Societies, Aug 2014, Paris, France. pp.65, ⟨10.1111/febs.12919⟩
Conference papers hal-02395537v1

Development of chemiluminescent probes for enzymatic activity detection.

Steven Vertueux , Kathleen Solmont , Alexandre Haefele , Philippe Durand , Pierre-Yves Renard
Journées du Groupement de recherche agents d'imagerie moléculaire (GDR AIM, 2, 2019), May 2019, Dijon, France
Conference poster hal-02556313v1

Synthesis and in vitro and in vivo evaluations of New Uncharged reactivators for cholinesterases inhibited by organophosphorus nerve agents

Anissa Braïki , Julien Renou , Romain Mougeot , Florian Nachon , José Dias
Medical Chemical Defense Conference (MCDC, 17, 2019), Mar 2019, Munich, Germany
Conference poster hal-02543452v1

Synthesis and evaluations of uncharged reactivators for cholinesterases inhibited by organophosphate agents

Anissa Braïki , Julien Renou , Romain Mougeot , Florian Nachon , André-Guilhem Calas
International Conference on Chemical Biological Radiological and Nuclear agents (CBRN) - Research & Innovation (3, 2019), May 2019, Nantes, France
Conference poster hal-02543439v1

Development of chemiluminescent probes for enzymatic activity detection.

Alexandre Haefele , Kathleen Solmont , Philippe Durand , Pierre-Yves Renard
Journées du Groupement de recherche agents d'imagerie moléculaire (GDR AIM, 1, 2018), Jun 2018, Orléans, France
Conference poster hal-02556312v1

Development of miniaturized fluorescence-based device for mycotoxin detection

Dorra Gargouri , Abdelaaziz Ouahrouch , Alexandre Haefele , Julien Vieillard , Xavier Franck
Rencontres en chimie organique biologique (RECOB, 17, 2018), Mar 2018, Aussois, France
Conference poster hal-02556310v1

Uncharged reactivators of cholinesterases inhibited by organophosphorus nerve agents.

Nicolas Probst , Anissa Braïki , Pierre Warnault , Julien Renou , Catherine Gomez
International Meeting on Cholinesterases (13, 2018) and International Conference on Paraoxonases (7, 2018)), Sep 2018, Hradec Králové, Czech Republic
Conference poster hal-02543467v1

Development of miniaturized fluorescence-based device for mycotoxin detection

Dorra Gargouri , Abdelaaziz Ouahrouch , Alexandre Haefele , Julien Vieillard , Xavier Franck
Journée de l’Ecole doctorale normande de chimie (JEDNC, 2018), Jun 2018, Rouen, France
Conference poster hal-02556309v1

Development of a caspase-3 probe for apoptosis detection by dual optical-nuclear imaging

Morgane Detraz , Alexandre Haefele , Pierre-Yves Renard , Pierre Bohn
Rencontre ChiMi. Fluorescence : de la paillasse à l'utilisation clinique, Jan 2018, Dijon, France
Conference poster hal-02556303v1

New Uncharged reactivators for cholinesterases inhibited by organophosphorus nerve agents

Anissa Braïki , Julien Renou , Romain Mougeot , Tamara Zorbaz , André-Guilhem Calas
International Conference on Chemical Biological Radiological nuclear Explosive - Research & Innovation (CBRNE, 2, 2017), May 2017, Lyon, France
Conference poster hal-02544823v1

Development of miniaturized fluorescence-based device for mycotoxin detection

Dorra Gargouri , Abdelaaziz Ouahrouch , Alexandre Haefele , Julien Vieillard , Xavier Franck
Journée de l’Ecole doctorale normande de chimie (JEDNC, 2017), Jun 2017, Rouen, France
Conference poster hal-02556306v1

Development of a caspase-3 probe for apoptosis detection by dual optical-nuclear imaging

Morgane Detraz , Alexandre Haefele , Pierre-Yves Renard , Pierre Bohn
Journées de l’Ecole doctorale normande Biologie Intégrative, Santé, Environnement (EdN BISE, 20, 2017), Mar 2017, Le Havre, France
Conference poster hal-02556299v1

Development of miniaturized fluorescence-based device for mycotoxin detection

Dorra Gargouri , Abdelaaziz Ouahrouch , Alexandre Haefele , Julien Vieillard , Xavier Franck
Journée Nord-Ouest Européennes des Jeunes Chercheurs et du Groupe Français des Polymères Grand Ouest (JNOEJC), Jun 2017, Caen, France
Conference poster hal-02556308v1

Development of chemiluminescent probes for enzymatic activity detection.

Kathleen Solmont , Virgile Grandclaude , Jean-Alexandre Richard , Alexandre Haefele , Philippe Durand
International Caparica Conference on Chromogenic and Emissive Materials (I3CEM, 2, 2016), Sep 2016, Lisbonne, Portugal
Conference poster hal-02556284v1

Development of chemiluminescent probes for enzymatic activity detection.

Kathleen Solmont , Alexandre Haefele , Philippe Durand , Pierre-Yves Renard
Journée de l’Ecole doctorale normande de chimie (JEDNC, 2016), Jun 2016, Caen, France
Conference poster hal-02556287v1

Multi Target directed ligands for the treatment of Alzheimer’s disease

Sovy Chao , Killian Oukoloff , Monika Bouet , Diego Muñoz Torrero , Jacques-Philippe Colletier
Rencontres internationales de chimie thérapeutique (RICT, 52, 2016), Jul 2016, Caen, France
Conference poster hal-02544849v1

Development of a caspase-3 probe for apoptosis detection by dual optical-nuclear imaging

Morgane Detraz , Alexandre Haefele , Pierre-Yves Renard , Pierre Bohn
International Caparica Conference on Chromogenic and Emissive Materials (I3CEM, 2, 2016), Sep 2016, Lisbonne, Portugal
Conference poster hal-02556296v1

Development of chemiluminescent probes for enzymatic activity detection.

Kathleen Solmont , Alexandre Haefele , Philippe Durand , Pierre-Yves Renard
PSL Chemical Biology Symposium, Dec 2016, Paris, France
Conference poster hal-02556279v1

Development of a caspase-3 probe for apoptosis detection by dual optical-nuclear imaging

Morgane Detraz , Alexandre Haefele , Pierre-Yves Renard , Pierre Bohn
Journées de l’Ecole doctorale normande Biologie Intégrative, Santé, Environnement (EdN BISE, 19, 2016), Mar 2016, Caen, France
Conference poster hal-02556291v1

Selective and Sensitive Near-Infrared Fluorescent Probe for Acetylcholinesterases Imaging

Sovy Chao , Eric Krejci , Véronique Bernard , Jacqueline Leroy , Ludovic Jean
International Symposium on Cholinergic Mechanisms (ISCM, 15, 2016), Oct 2016, Marseille, France
Conference poster hal-02544874v1

Development of a caspase-3 probe for apoptosis detection bu dual optical-nuclear imaging

M Detraz , Py Renard , P Vera , A Haefele , P Bohn
IC3EM, Sep 2016, Caparica, Portugal
Conference poster hal-01663947v1

Synthesis of new uncharged reactivators for cholinesterases inhibited by organophosphorus nerve agents

Anissa Braïki , Julien Renou , Catherine Gomez , Romain Mougeot , Florian Nachon
Tetrahedron Symposium (17, 2016), Jun 2016, Barcelone, Spain
Conference poster hal-02544884v1

Development of a caspase-3 probe for apoptosis detection bu dual optical-nuclear imaging

M Detraz , A Haefele , Py Renard , P Bohn
Chemical Biology Symposium, Dec 2016, Paris, France
Conference poster hal-01663935v1

Development of chemiluminescent probes for enzymatic activity detection.

Kathleen Solmont , Virgile Grandclaude , Jean-Alexandre Richard , Alexandre Haefele , Philippe Durand
Anglo-Norman colloquium on organic chemistry (ANORCQ, 13, 2016), Apr 2016, Rouen, France
Conference poster hal-02556286v1

Design and Development of New Uncharged Reactivators of OP-Inhibited Cholinesterases

Pierre Warnault , Julien Renou , Catherine Gomez , Guillaume Mercey , Tristan Verdelet
International Conference on Chemical Biological Radiological and Nuclear agents (CBRN) - Research & Innovation (1, 2015), Mar 2015, Antibes, France
Conference poster hal-02544917v1

Uncharged Reactivators of cholinesterases Inhibited by organophosphorus nerve agents

Pierre Warnault , Julien Renou , Catherine Gomez , Guillaume Mercey , Tristan Verdelet
International Meeting on Cholinesterases - Sixth International Conference on Paraoxonases (12, 2015), Sep 2015, Elche, Spain
Conference poster hal-02544902v1

Phosphoryl compounds

Pierre-Yves Renard , Christopher Timperley , Catherine Gomez
Best Synthetic Methods: Organophosphorus (V), Academic press, pp.365-562, 2014, 978-0-08-098212-0. ⟨10.1016/C2011-0-04165-0⟩
Book sections hal-02345183v1