Przybyłek Maciej I. EDUCATION AND ACADEMIC DEGREES1) A graduate of the Faculty of Technology and Chemical Engineering at the University of Technology and Life Science in Bydgoszcz (2010), field of study: Chemical Technology, field of specialization: Technology ofChemical Process.2) Doctorate in Pharmacy at the Nicolaus Copernicus University (2016), PhD Thesis: &quot;Studies on the orientation effect of crystallites and its application to cocrystal screening of selected pharmacologically active compounds&quot;3) Habilitation in Pharmacy at the Nicolaus Copernicus University (2024), &quot;Experimental and theoretical studies of the solubility of selected pharmaceuticals and their affinity to other substances in the solid and liquid phase&quot;II. PROFESSIONAL EXPERIENCE1)December 2011 - October 2018: Assistant at Department of Physical Chemistry, Pharmacy Faculty, Collegium Medicum of Bydgoszcz, Nicolaus Copernicus University in Toruń.2) October 2018 - Present: Assistant Professor at Department of Physical Chemistry, Pharmacy Faculty, Collegium Medicum of Bydgoszcz, Nicolaus Copernicus University in Toruń.

Identifiants chercheurs

IdHAL :

przybyek-maciej

ORCID :

0000-0002-3399-6129

ResearcherID :

D-6353-2014

Présentation

Publications

Article dans une revue (47)

Navigating the Deep Eutectic Solvent Landscape: Experimental and Machine Learning Solubility Explorations of Syringic, p-Coumaric, and Caffeic Acids Piotr Cysewski,Tomasz Jeliński,Maciej Przybyłek,Natalia Gliniewicz,Marcel Majkowskiet al. International Journal of Molecular Sciences, 2025, 26 (20), pp.10099. ⟨10.3390/ijms262010099⟩ Article dans une revue hal-05318657v1
Data-Driven Classification of Solubility Space in Deep Eutectic Solvents: Deciphering Driving Forces Using PCA and K-Means Clustering Piotr Cysewski,Maciej Przybyłek,Tomasz Jeliński Molecules, 2025, 30 (23), pp.4563. ⟨10.3390/molecules30234563⟩ Article dans une revue hal-05388529v1
Tribological effects of hyaluronic acid concentration on articular cartilage: pin-on-plate friction tests in porcine and osteoarthritic human tissue Adam J Mazurkiewicz,Celina Pezowicz,Anna Nikodem,Maciej Przybyłek,Dominika Mazurkiewicz Journal of Theoretical and Applied Mechanics, 2025, ⟨10.15632/jtam-pl/210752⟩ Article dans une revue hal-05318653v1
Coconut Milk-Derived Bioactive Peptides as Multifunctional Agents Against Hyperglycemia, Oxidative Stress, and Glycation: An Integrated Experimental and Computational Study Akshaya Simha Naganarasimha,Shashank M Patil,Ramith Ramu,Maciej Przybyłek,Piotr Bełdowskiet al. International Journal of Molecular Sciences, 2025, 27 (1), pp.360. ⟨10.3390/ijms27010360⟩ Article dans une revue hal-05435834v1
From Molecular Interactions to Solubility in Deep Eutectic Solvents: Exploring Flufenamic Acid in Choline-Chloride- and Menthol-Based Systems Piotr Cysewski,Tomasz Jeliński,Oliwia Kukwa,Maciej Przybyłek Molecules, 2025, 30 (16), pp.3434. ⟨10.3390/molecules30163434⟩ Article dans une revue hal-05217022v1
Identification and 3D modeling of bioactive peptides from Lactobacillus brevis RAMULAB49 protein hydrolysate with in silico ERK1 phosphorylation inhibition activity targeting diabetic nephropathy Reshma Mary Martiz,Ramith Ramu,Hemalatha Nambisan,Ameer Suhail,Mohammad Raishet al. PLoS ONE, 2025, 20 (9), pp.e0331192. ⟨10.1371/journal.pone.0331192⟩ Article dans une revue hal-05281859v1
Exploration of the Solubility Hyperspace of Selected Active Pharmaceutical Ingredients in Choline-and Betaine-Based Deep Eutectic Solvents: Machine Learning Modeling and Experimental Validation Piotr Cysewski,Tomasz Jeli,Maciej Przybyłek Molecules, 2024, 29 (20), pp.4894. ⟨10.3390/molecules29204894⟩ Article dans une revue hal-04740525v1
Experimental and Theoretical Insights into the Intermolecular Interactions in Saturated Systems of Dapsone in Conventional and Deep Eutectic Solvents Piotr Cysewski,Tomasz Jeliński,Maciej Przybyłek Molecules, 2024, 29 (8), pp.1743. ⟨10.3390/molecules29081743⟩ Article dans une revue hal-04543084v1
Experimental and Machine-Learning-Assisted Design of Pharmaceutically Acceptable Deep Eutectic Solvents for the Solubility Improvement of Non-Selective COX Inhibitors Ibuprofen and Ketoprofen Piotr Cysewski,Tomasz Jeliński,Maciej Przybyłek,Anna Mai,Julia Kułak Molecules, 2024, 29 (10), pp.2296. ⟨10.3390/molecules29102296⟩ Article dans une revue hal-04575510v1
Deep Eutectic Solvents as Agents for Improving the Solubility of Edaravone: Experimental and Theoretical Considerations Tomasz Jeliński,Maciej Przybyłek,Magdalena Mianowana,Kinga Misiak,Piotr Cysewski Molecules, 2024, 29 (6), pp.1261. ⟨10.3390/molecules29061261⟩ Article dans une revue hal-04543106v1
Effect of Nanohydroxyapatite on Silk Fibroin-Chitosan Interactions-Molecular Dynamics Study Maciej Przybył,Anna Tuwalska,Damian Ledziński,Sandra Śmigiel,Alina Sionkowskaet al. Applied Sciences, 2024, 14 (10), pp.4131. ⟨10.3390/app14104131⟩ Article dans une revue hal-04574093v1
Tuning Ferulic Acid Solubility in Choline-Chloride- and Betaine-Based Deep Eutectic Solvents: Experimental Determination and Machine Learning Modeling Tomasz Jeliński,Maciej Przybyłek,Rafal Rozalski,Karolina Romanek,Daniel Wielewskiet al. Molecules, 2024, 29 (16), pp.3841. ⟨10.3390/molecules29163841⟩ Article dans une revue hal-04671140v1
Molecular Insights into the Interactions Between Human Serum Albumin and Phospholipid Membranes Maciej Przybyłek,Piotr Bełdowski,Zbigniew Lutowski,Damian Ledziński,Adam Mazurkiewiczet al. Applied Sciences, 2024, 14 (24), pp.11753. ⟨10.3390/app142411753⟩ Article dans une revue hal-04843734v1
Exploring the Solubility Limits of Edaravone in Neat Solvents and Binary Mixtures: Experimental and Machine Learning Study Maciej Przybyłek,Tomasz Jeliński,Magdalena Mianowana,Kinga Misiak,Piotr Cysewski Molecules, 2023, 28 (19), pp.6877. ⟨10.3390/molecules28196877⟩ Article dans une revue hal-04223421v1
Intermolecular Interactions as a Measure of Dapsone Solubility in Neat Solvents and Binary Solvent Mixtures Piotr Cysewski,Maciej Przybyłek,Tomasz Jeliński Materials, 2023, 16 (18), pp.6336. ⟨10.3390/ma16186336⟩ Article dans une revue hal-04215566v1
Collagen Type II-Chitosan Interactions as Dependent on Hydroxylation and Acetylation Inferred from Molecular Dynamics Simulations Maciej Przybyłek,Piotr Bełdowski,Florian Wieland,Piotr Cysewski,Alina Sionkowska Molecules, 2023, ⟨10.3390/molecules28010154⟩ Article dans une revue hal-03912638v1
Molecular dynamics simulations of the affinity of chitin and chitosan for collagen: the effect of pH and the presence of sodium and calcium cations Maciej Przybyłek,Piotr Bełdowski Progress on Chemistry and Application of Chitin and its Derivatives, 2023, 28, pp.136-150. ⟨10.15259/PCACD.28.013⟩ Article dans une revue hal-04231879v1
New Insights into Thermodynamics of Solutes in Neat and Complex Solvents Piotr Cysewski,Tomasz Jeliński,Maciej Przybyłek Molecules, 2022, ⟨10.3390/molecules27186131⟩ Article dans une revue hal-03780993v1
Application of COSMO-RS-DARE as a Tool for Testing Consistency of Solubility Data: Case of Coumarin in Neat Alcohols Piotr Cysewski,Tomasz Jeli,Maciej Przybyłek Molecules, 2022, 27 (16), pp.5274. ⟨10.3390/molecules27165274⟩ Article dans une revue hal-03753795v1
Effect of Chitosan Deacetylation on Its Affinity to Type III Collagen: A Molecular Dynamics Study Piotr Bełdowski,Maciej Przybyłek,Ali Sionkowska,Piotr Cysewski,Magdalena Gadomskaet al. Materials, 2022, 15 (2), pp.463. ⟨10.3390/ma15020463⟩ Article dans une revue hal-03517990v1
Solubility Characteristics of Acetaminophen and Phenacetin in Binary Mixtures of Aqueous Organic Solvents: Experimental and Deep Machine Learning Screening of Green Dissolution Media Piotr Cysewski,Tomasz Jeliński,Maciej Przybyłek,Wiktor Nowak,Michał Olczak Pharmaceutics, 2022, ⟨10.3390/pharmaceutics14122828⟩ Article dans une revue hal-03903876v1
Albumin–Hyaluronan Interactions: Influence of Ionic Composition Probed by Molecular Dynamics Piotr Bełdowski,Maciej Przybyłek,Przemysław Raczyński,Andra Dedinaite,Krzysztof Górnyet al. International Journal of Molecular Sciences, 2021, 22 (22), pp.12360. ⟨10.3390/ijms222212360⟩ Article dans une revue hal-03431920v1
Experimental and Theoretical Screening for Green Solvents Improving Sulfamethizole Solubility Piotr Cysewski,Maciej Przybyłek,Rafal Rozalski Materials, 2021, ⟨10.3390/ma14205915⟩ Article dans une revue hal-03372170v1
Thermodynamic Characteristics of Phenacetin in Solid State and Saturated Solutions in Several Neat and Binary Solvents Maciej Przybyłek,Anna Kowalska,Natalia Tymorek,Tomasz Dziaman,Piotr Cysewski Molecules, 2021, 26 (13), pp.4078. ⟨10.3390/molecules26134078⟩ Article dans une revue hal-03278334v1
Studies on the solid-liquid equilibria and intermolecular interactions Urea binary mixtures with Sulfanilamide and Sulfacetamide Maciej Przybyłek,Patrycja Walczak,Dorota Ziółkowska,Izabela Grela,Piotr Cysewski The Journal of Chemical Thermodynamics, 2021, 153, pp.106308. ⟨10.1016/j.jct.2020.106308⟩ Article dans une revue hal-02954736v1
Thermodynamics and Intermolecular Interactions of Nicotinamide in Neat and Binary Solutions: Experimental Measurements and COSMO-RS Concentration Dependent Reactions Investigations Piotr Cysewski,Maciej Przybyłek,Anna Kowalska,Natalia Tymorek International Journal of Molecular Sciences, 2021, 22 (14), pp.7365. ⟨10.3390/ijms22147365⟩ Article dans une revue hal-03283187v1
Solvent Screening for Solubility Enhancement of Theophylline in Neat, Binary and Ternary NADES Solvents: New Measurements and Ensemble Machine Learning Piotr Cysewski,Tomasz Jeliński,Patryk Cymerman,Maciej Przybyłek International Journal of Molecular Sciences, 2021, 22 (14), pp.7347. ⟨10.3390/ijms22147347⟩ Article dans une revue hal-03284285v1
Application 2D Descriptors and Artificial Neural Networks for Beta-Glucosidase Inhibitors Screening Maciej Przybyłek Molecules, 2020, ⟨10.3390/molecules25245942⟩ Article dans une revue hal-03070564v1
Solubility of sulfanilamide in binary solvents containing water: Measurements and prediction using Buchowski-Ksiazczak solubility model Tomasz Jeliński,Natalia Bugalska,Kinga Koszucka,Maciej Przybyłek,Piotr Cysewski Journal of Molecular Liquids, 2020, 319, pp.114342. ⟨10.1016/j.molliq.2020.114342⟩ Article dans une revue hal-02943573v1
Natural Deep Eutectic Solvents as Agents for Improving Solubility, Stability and Delivery of Curcumin Tomasz Jeliński,Maciej Przybyłek,Piotr Cysewski Pharmaceutical Research, 2019, 36 (8), ⟨10.1007/s11095-019-2643-2⟩ Article dans une revue hal-02184283v1
Predicting Value of Binding Constants of Organic Ligands to Beta-Cyclodextrin: Application of MARSplines and Descriptors Encoded in SMILES String Piotr Cysewski,Maciej Przybyłek Symmetry, 2019, 11 (7), pp.922. ⟨10.3390/sym11070922⟩ Article dans une revue hal-02184280v1
Solubility advantage of sulfanilamide and sulfacetamide in natural deep eutectic systems: experimental and theoretical investigations Tomasz Jeliński,Maciej Przybyłek,Piotr Cysewski Drug Development and Industrial Pharmacy, 2019, ⟨10.1080/03639045.2019.1597104⟩ Article dans une revue hal-02073396v1
Application of Multivariate Adaptive Regression Splines (MARSplines) for Predicting Hansen Solubility Parameters Based on 1D and 2D Molecular Descriptors Computed from SMILES String Maciej Przybyłek,Tomasz Jeliński,Piotr Cysewski Journal of Chemistry , 2019, ⟨10.1155/2019/9858371⟩ Article dans une revue hal-01977664v1
The use of fast molecular descriptors and artificial neural networks approach in organochlorine compounds electron ionization mass spectra classification Maciej Przybyłek,Waldemar Studziński,Alicja Gackowska,Jerzy Gaca Environmental Science and Pollution Research, 2019, 26 (27), pp.28188-28201. ⟨10.1007/s11356-019-05968-4⟩ Article dans une revue hal-02318325v1
Distinguishing Cocrystals from Simple Eutectic Mixtures: Phenolic Acids as Potential Pharmaceutical Coformers Maciej Przybyłek,Piotr Cysewski Crystal Growth & Design, 2018, 18 (6), pp.3524-3534. ⟨10.1021/acs.cgd.8b00335⟩ Article dans une revue hal-01783502v1
Studies on the formation of formaldehyde during 2-ethylhexyl 4-(dimethylamino)benzoate demethylation in the presence of reactive oxygen and chlorine species Waldemar Studziński,Alicja Gackowska,Maciej Przybyłek,Jerzy Gaca Environmental Science and Pollution Research, 2017, 24 (9), pp.8049-8061. ⟨10.1007/s11356-017-8477-8⟩ Article dans une revue hal-01773002v1
Applicability of Phenolic Acids as Effective Enhancers of Cocrystal Solubility of Methylxanthines Maciej Przybyłek,Dorota Ziółkowska,Karina Mroczyńska,Piotr Cysewski Crystal Growth & Design, 2017, 17 (4), pp.2186 - 2193. ⟨10.1021/acs.cgd.7b00121⟩ Article dans une revue hal-01773089v1
Selection of effective cocrystals former for dissolution rate improvement of active pharmaceutical ingredients based on lipoaffinity index Piotr Cysewski,Maciej Przybyłek European Journal of Pharmaceutical Sciences, 2017, 107, pp.87-96. ⟨10.1016/j.ejps.2017.07.004⟩ Article dans une revue hal-01773096v1
Formation of chlorinated breakdown products during degradation of sunscreen agent, 2-ethylhexyl-4-methoxycinnamate in the presence of sodium hypochlorite Alicja Gackowska,Maciej Przybyłek,Waldemar Studziński,Jerzy Gaca Environmental Science and Pollution Research, 2016, 23 (2), pp.1886-1897. ⟨10.1007/s11356-015-5444-0⟩ Article dans une revue hal-01772993v1
Utilization of oriented crystal growth for screening of aromatic carboxylic acids cocrystallization with urea Maciej Przybyłek,Dorota Ziółkowska,Mirosław Kobierski,Karina Mroczyńska,Piotr Cysewski Journal of Crystal Growth, 2016, 433, pp.128 - 138. ⟨10.1016/j.jcrysgro.2015.10.015⟩ Article dans une revue hal-01773010v1
Propensity of salicylamide and ethenzamide cocrystallization with aromatic carboxylic acids Maciej Przybyłek,Dorota Ziółkowska,Karina Mroczyńska,Piotr Cysewski European Journal of Pharmaceutical Sciences, 2016, 85, pp.132 - 140. ⟨10.1016/j.ejps.2016.02.010⟩ Article dans une revue hal-01773016v1
Exploring the cocrystallization potential of urea and benzamide Piotr Cysewski,Maciej Przybyłek,Dorota Ziółkowska,Karina Mroczyńska Journal of Molecular Modeling, 2016, 22 (5), pp.103. ⟨10.1007/s00894-016-2964-6⟩ Article dans une revue hal-01773091v1
On the origin of surface imposed anisotropic growth of salicylic and acetylsalicylic acids crystals during droplet evaporation Maciej Przybyłek,Piotr Cysewski,Maciej Pawelec,Dorota Ziółkowska,Mirosław Kobierski Journal of Molecular Modeling, 2015, 21 (3), pp.49. ⟨10.1007/s00894-015-2599-z⟩ Article dans une revue hal-01772925v1
On the origin of surfaces-dependent growth of benzoic acid crystal inferred through the droplet evaporation method Piotr Cysewski,Maciej Przybyłek,Tomasz Miernik,Mirosław Kobierski,Dorota Ziółkowska Structural Chemistry, 2015, 26 (3), pp.705 - 712. ⟨10.1007/s11224-014-0528-x⟩ Article dans une revue hal-01773094v1
Experimental and theoretical studies on the photodegradation of 2-ethylhexyl 4-methoxycinnamate in the presence of reactive oxygen and chlorine species Alicja Gackowska,Maciej Przybyłek,Waldemar Studziński,Jerzy Gaca Central European Journal of Chemistry, 2014, 12 (5), pp.612 - 623. ⟨10.2478/s11532-014-0522-6⟩ Article dans une revue hal-01773085v1
Reaction of aniline with ammonium persulphate and concentrated hydrochloric acid: Experimental and DFT studies Maciej Przybyłek,Jerzy Gaca Chemical Papers, 2012, 66 (7), pp.699-708. ⟨10.2478/s11696-012-0163-1⟩ Article dans une revue hal-01773005v1
Color prediction from first principle quantum chemistry computations: a case of alizarin dissolved in methanol Piotr Cysewski,Tomasz Jeliński,Maciej Przybyłek,Aleksander Shyichuk New Journal of Chemistry, 2012, 36 (9), ⟨10.1039/c2nj40327g⟩ Article dans une revue hal-01773088v1