Rabah Gahoual Enseignant-chercheur en chimie analytiqueUniversité Paris Cité, Faculté de Pharmacie

Identifiants chercheurs

IdHAL :

rgahoual

ORCID :

0000-0001-8459-3138

Publications

Article dans une revue (30)

Characterization and quantification of therapeutic monoclonal antibodies, anti-drug antibodies and their interactions for clinical applications Lola Alez-Martin,Emilie Hirschler,Pascal Houzé,Noëlle Potier,Nathalie Mignetet al. Trends in Analytical Chemistry, 2025, 192, pp.118385. ⟨10.1016/j.trac.2025.118385⟩ Article dans une revue hal-05390034v1
Therapeutic monoclonal antibody - Anti-drug antibody affinity constant determination using capillary electrophoresis -tandem mass spectrometry Tessa Reinert,Pascal Houzé,Nathalie Mignet,Aynur Naghizade,Lola Alez-Martinet al. Analytical Chemistry, 2024, 96 (49), pp.19286-19293. ⟨10.1021/acs.analchem.4c02932⟩ Article dans une revue hal-05237144v1
Post-translational modifications comparative identification and kinetic study of infliximab innovator and biosimilars in serum using capillary electrophoresis-tandem mass spectrometry Tessa Reinert,Pascal Houzé,Nathalie Mignet,Yannis-Nicolas Francois,Rabah Gahoual Journal of Pharmaceutical and Biomedical Analysis, 2023, 234, pp.115541. ⟨10.1016/j.jpba.2023.115541⟩ Article dans une revue hal-04599782v1
Simultaneous quantification and structural characterization of monoclonal antibodies after administration using capillary zone electrophoresis-tandem mass spectrometry Tessa Reinert,Rabah Gahoual,Nathalie Mignet,Alexandre Kulus,Matthieu Allezet al. Journal of Pharmaceutical and Biomedical Analysis, 2023, 233, pp.115446. ⟨10.1016/j.jpba.2023.115446⟩ Article dans une revue hal-04599685v1
Designing fisetin nanocrystals for enhanced in cellulo anti-angiogenic and anticancer efficacy Panpan Ma,Johanne Seguin,Nhu Ky Ly,Luis Castillo-Henríquez,Eva Plansartet al. International Journal of Pharmaceutics: X, 2022, 4, pp.100138. ⟨10.1016/j.ijpx.2022.100138⟩ Article dans une revue hal-04090295v1
CEToolbox: Specialized calculator for capillary electrophoresis users as an android application Yannis François,Michael Biacchi,Rabah Gahoual,Aurélien Vezin,Jerôme Pansanel Electrophoresis, 2021, 42 (14-15), pp.1431-1435. ⟨10.1002/elps.202100036⟩ Article dans une revue hal-03408175v1
Comprehensive and quantitative stability study of ascorbic acid using capillary zone electrophoresis with ultraviolet detection and high-resolution tandem mass spectrometry Pauline Legrand,Rabah Gahoual,Raphael Benattar,Balthazar Toussaint,Caroline Roqueset al. Journal of Separation Science, 2020, 43 (14), pp.2925-2935. ⟨10.1002/jssc.202000389⟩ Article dans une revue hal-03289975v1
Kinetic and structural characterization of therapeutic albumin chemical functionalization using complementary mass spectrometry techniques Rabah Gahoual,Gérard Bolbach,Ikram Ould-Melha,Gilles Clodic,Yannis Francoiset al. Journal of Pharmaceutical and Biomedical Analysis, 2020, 185, pp.113242. ⟨10.1016/j.jpba.2020.113242⟩ Article dans une revue hal-03022806v1
Cutting-edge multi-level analytical and structural characterization of antibody-drug conjugates: present and future Alain Beck,Valentina D’atri,Anthony Ehkirch,Szabolcs Fekete,Oscar Hernandez-Albaet al. Expert Review of Proteomics, 2019, 16 (4), pp.337-362. ⟨10.1080/14789450.2019.1578215⟩ Article dans une revue hal-02272143v1
Conception of nanosized hybrid liposome/poloxamer particles to thicken the interior core of liposomes and delay hydrophilic drug delivery Shayan Ahmed,Yohann Corvis,Rabah Gahoual,Arlen Euan,Rene Lai-Kuenet al. International Journal of Pharmaceutics, 2019, 567, ⟨10.1016/j.ijpharm.2019.118488⟩ Article dans une revue hal-03290600v1
Site-specific N-and O-glycosylation analysis of atacicept Kathrin Stavenhagen,Rabah Gahoual,Elena Dominguez Vega,Angelo Palmese,Agnes L Hipgrave Ederveenet al. mAbs, 2019, 11 (6), pp.1053-1063. ⟨10.1080/19420862.2019.1630218⟩ Article dans une revue hal-03175711v1
Is Capillary Electrophoresis a New Tool to Monitor Acute Lithium Poisoning in Human? Tsandni Jamal,Carole Hennequin,Rabah Gahoual,Annie Leyris,Jean-Louis Beaudeuxet al. Journal of Analytical Toxicology, 2019, 43 (7), pp.571-578. ⟨10.1093/jat/bkz013⟩ Article dans une revue hal-03175919v1
Europium labeled lactosylated albumin as a model workflow for the development of biotherapeutics Hugo Salmon,Rabah Gahoual,Pascal Houzé,Tayssir Ibrahim,Michel Bessodeset al. Nanomedicine: Nanotechnology, Biology and Medicine, 2019, 18, pp.21-30. ⟨10.1016/j.nano.2019.02.011⟩ Article dans une revue hal-02123126v1
Disorder-to-Order Markers of a Cyclic Hexapeptide Inspired from the Binding Site of Fertilin β Involved in Fertilization Process Belén Henández,Pauline Legrand,Sophie Dufay,Rabah Gahoual,Santiago Sanchez-Cor- Teset al. ACS Omega, 2019, ⟨10.1021/acsomega.9b01885⟩ Article dans une revue hal-03183727v1
Insights from capillary electrophoresis approaches for characterization of monoclonal antibodies and antibody drug conjugates in the period 2016–2018 Antony Lechner,Jeremie Giorgetti,Rabah Gahoual,Alain Beck,Emmanuelle Leize-Wagneret al. Journal of Chromatography B Biomedical Sciences and Applications, 2019, 1122-1123, pp.1-17. ⟨10.1016/j.jchromb.2019.05.014⟩ Article dans une revue hal-02399570v1
Affinity profiling of monoclonal antibody and antibodydrug-conjugate preparations by coupled liquid chromatography-surface plasmon resonance biosensing Dina Lakayan,Rob Haselberg,Rabah Gahoual,Govert W Somsen,Jeroen Kool Analytical and Bioanalytical Chemistry, 2018, 410 (30), pp.7837-7848. ⟨10.1007/s00216-018-1414-y⟩ Article dans une revue hal-03039563v1
Revealing the potential of capillary electrophoresis/mass spectrometry: the tipping point Rabah Gahoual,Emmanuelle Leize‐wagner,Pascal Houzé,Yannis‐nicolas François Rapid Communications in Mass Spectrometry, 2018, 1st European Mass Spectrometry Conference (EMSC), 33 (S1), pp.11 - 19. ⟨10.1002/rcm.8238⟩ Article dans une revue hal-03892201v2
Advanced Antibody-Drug Conjugate Structural Characterization by Sheathless Capillary Electrophoresis-Tandem Mass Spectrometry Using Complementary Approaches Nassur Said,Jérémie Giorgetti,Lauriane Kuhn,Alain Beck,Emmanuelle Leize-Wagneret al. LCGC Current Trends in Mass Spectroscopy, 2017, 15 (1), pp.15-21 Article dans une revue hal-03206734v1
Detailed Characterization of Monoclonal Antibody Receptor Interaction Using Affinity Liquid Chromatography Hyphenated to Native Mass Spectrometry Rabah Gahoual,Anna-Katharina Heidenreich,Govert W Somsen,Patrick Bulau,Dietmar Reuschet al. Analytical Chemistry, 2017, 89 (10), pp.5404-5412. ⟨10.1021/acs.analchem.7b00211⟩ Article dans une revue hal-03206846v1
Independent highly sensitive characterization of asparagine deamidation and aspartic acid isomerization by sheathless CZE-ESI-MS/MS Rabah Gahoual,Alain Beck,Yannis-Nicolas François,Emmanuelle Leize-Wagner Journal of Mass Spectrometry, 2016, 51 (2), pp.150-158. ⟨10.1002/jms.3735⟩ Article dans une revue hal-01981310v1
Characterization of cetuximab Fc/2 dimers by off-line CZE-MS Yannis-Nicolas François,Michael Biacchi,Nassur Said,Charly Renard,Alain Becket al. Analytica Chimica Acta, 2016, 908, pp.168-176. ⟨10.1016/j.aca.2015.12.033⟩ Article dans une revue hal-01981314v1
Cutting-edge capillary electrophoresis characterization of monoclonal antibodies and related products Rabah Gahoual,Alain Beck,Emmanuelle Leize-Wagner,Yannis-Nicolas François Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2016, 1032, pp.61-78. ⟨10.1016/j.jchromb.2016.05.028⟩ Article dans une revue hal-01981308v1
Structural characterization of antibody drug conjugate by a combination of intact, middle-up and bottom-up techniques using sheathless capillary electrophoresis – Tandem mass spectrometry as nanoESI infusion platform and separation method Nassur Said,Rabah Gahoual,Lauriane Kuhn,Alain Beck,Yannis-Nicolas Francoiset al. Analytica Chimica Acta, 2016, 918, pp.50-59. ⟨10.1016/j.aca.2016.03.006⟩ Article dans une revue hal-01981303v1
Improvement of Mitochondria Extract from Saccharomyces cerevisiae Characterization in Shotgun Proteomics Using Sheathless Capillary Electrophoresis Coupled to Tandem Mass Spectrometry Marianne Ibrahim,Rabah Gahoual,Ludovic Enkler,Hubert Becker,Johana Chicheret al. Journal of Chromatographic Science, 2016, 54 (4), pp.653-663. ⟨10.1093/chromsci/bmw005⟩ Article dans une revue hal-02918628v1
Priming cells for their final destination: microenvironment controlled cell culture by a modular ECM-mimicking feeder film Julien Barthes,Nihal E. Vrana,Hayriye Oezcelik,Rabah Gahoual,Yannis N. Francoiset al. Biomaterials Science, 2015, 3 (9), pp.1302-1311. ⟨10.1039/c5bm00172b⟩ Article dans une revue hal-01505605v1
Glycoform Separation and Characterization of Cetuximab Variants by Middle-up Off-Line Capillary Zone Electrophoresis-UV/Electrospray Ionization-MS Michael Biacchi,Rabah Gahoual,Nassur Said,Alain Beck,Emmanuelle Leize-Wagneret al. Analytical Chemistry, 2015, 87 (12), pp.6240-6250. ⟨10.1021/acs.analchem.5b00928⟩ Article dans une revue hal-01981309v1
Novel sheathless CE-MS interface as an original and powerful infusion platform for nanoESI study: from intact proteins to high molecular mass noncovalent complexes. Rabah Gahoual,Jean-Marc Busnel,Philippe Wolff,Yannis François,Emmanuelle Leize-Wagner Analytical and Bioanalytical Chemistry, 2014, 406 (4), pp.1029-1038. ⟨10.1007/s00216-013-7226-1⟩ Article dans une revue hal-02991315v1
Full Antibody Primary Structure and Microvariant Characterization in a Single Injection Using Transient Isotachophoresis and Sheathless Capillary Electrophoresis–Tandem Mass Spectrometry Rabah Gahoual,Jean-Marc Busnel,Alain Beck,Yannis-Nicolas François,Emmanuelle Leize-Wagner Analytical Chemistry, 2014, 86 (18), pp.9074-9081. ⟨10.1021/ac502378e⟩ Article dans une revue hal-01981311v1
Monoclonal antibodies biosimilarity assessment using transient isotachophoresis capillary zone electrophoresis-tandem mass spectrometry Rabah Gahoual,Michaël Biacchi,Johana Chicher,Lauriane Kuhn,Philippe Hammannet al. mAbs, 2014, 6 (6), pp.1464-1473. ⟨10.4161/mabs.36305⟩ Article dans une revue hal-01981312v1
Rapid and multi-level characterization of trastuzumab using sheathless capillary electrophoresis-tandem mass spectrometry Rabah Gahoual,Alicia Burr,Jean-Marc Busnel,Lauriane Kuhn,Philippe Hammanet al. mAbs, 2013, 5 (3), pp.479-490. ⟨10.4161/mabs.23995⟩ Article dans une revue hal-01984367v1

Chapitre d'ouvrage (3)

Characterization of the Primary Structure of Cysteine-Linked Antibody-Drug Conjugates Using Capillary Electrophoresis with Mass Spectrometry Josiane Saadé,Rabah Gahoual,Alain Beck,Emmanuelle Leize-Wagner,Yannis-Nicolas Francois Antibody-Drug Conjugates. Methods in Molecular Biology, pp.263-272, 2020, ⟨10.1007/978-1-4939-9929-3_18⟩ Chapitre d'ouvrage hal-02399628v1
Capillary electrophoresis coupled to mass spectrometry as a powerful tool to investigate heterogeneities, conformers and oligomers of intact proteins Myriam Taverna,Nguyet Thuy Tran,Coralie Ruel,Yannis-Nicolas François,Anne-Lise Marieet al. Advances in Chromatography, 2019, 9780429026171. ⟨10.1201/9780429026171-5⟩ Chapitre d'ouvrage hal-04295470v1
Biopharmaceutical Applications of Capillary Electromigration Methods Rabah Gahoual,Jeremie Giorgetti,Alain Beck,Emmanuelle Leize-Wagner,Yannis-Nicolas Francois Capillary Electromigration Separation Methods, Elsevier, pp.453-480, 2018, ⟨10.1016/B978-0-12-809375-7.00021-6⟩ Chapitre d'ouvrage hal-02399612v1

Thèse (1)

Développement du couplage électrophorèse capillaire - spectrométrie de masse haute sensibilité : application à la caractérisation fine de protéines Rabah Gahoual Chimie analytique. Université de Strasbourg, 2014. Français. ⟨NNT : 2014STRAF040⟩ Thèse tel-01126909v1

Logiciel (1)

CEToolbox Yannis François,Jérôme Pansanel,Rabah Gahoual,Michael Biacchi,Aurélien Vezin 2019, ⟨swh:1:rev:3a5ae52630d3394180894cfc157f41cf659c365b⟩ Logiciel hal-05075387v1