Romain Haudecoeur

Publications

Autre publication scientifique (1)

Hydroquinone causes exogenous ochronosis through tyrosinase catalytic activity and highlights the need for genuine human tyrosinase inhibitors Morane Beaumet,Romain Haudecoeur 2025, ⟨10.1093/bjd/ljaf315⟩ Autre publication scientifique hal-05234704v1

Article dans une revue (32)

Aurones as new modulators of hypoxia inducible factor-1 (HIF-1) to prevent cardiac cell death Léa Di Maria,Brayan Roulier,Morane Beaumet,Romain Haudecoeur,Ahcène Boumendjelet al. Results in Chemistry, 2025, 17, pp.102609. ⟨10.1016/j.rechem.2025.102609⟩ Article dans une revue hal-05234686v1
Bistable and Water‐Operable Hemiindigo Photoswitches Allow Optical Control of Acetylcholinesterase Activity with Visible Light Letícia da Mata Lazinski,Morane Beaumet,Frédérique Loiseau,Cyril Goudet,Martial Boggio‐pasquaet al. ChemistryEurope, 2025, 3 (5), pp.e202500221. ⟨10.1002/ceur.202500221⟩ Article dans une revue hal-05339073v1
Aurones and derivatives as promising New Delhi metallo-β-lactamase (NDM-1) inhibitors Jérémy Caburet,Federica Verdirosa,Matis Moretti,Brayan Roulier,Giorgia Simoncelliet al. Bioorganic and Medicinal Chemistry Letters, 2024, 97, pp.117559. ⟨10.1016/j.bmc.2023.117559⟩ Article dans une revue hal-04429770v1
Design and Synthesis of Novel Amino and Acetamidoaurones with Antimicrobial Activities Attilio Di Maio,Hamza Olleik,Elise Courvoisier-Dezord,Sophie Guillier,Fabienne Neulat-Ripollet al. Antibiotics, 2024, 13 (4), pp.300. ⟨10.3390/antibiotics13040300⟩ Article dans une revue hal-04588387v1
Tyrosinase Inhibition and Antimelanogenic Effects of Resorcinol‐Containing Compounds Morane Beaumet,Leticia M Lazinski,Marc Maresca,Romain Haudecoeur ChemMedChem, 2024, ⟨10.1002/cmdc.202400314⟩ Article dans une revue hal-04768568v1
Expanding Chemical Frontiers: Approaches for Generating Diverse and Bioactive Natural Product-Like Compounds Libraries from Extracts Aurélien Beato,Romain Haudecoeur,Benjamin Boucherle,Marine Peuchmaur Chemistry - A European Journal, 2024, 30 (26), pp.e202304166. ⟨10.1002/chem.202304166⟩ Article dans une revue (article de synthèse) hal-04604571v1
Design and synthesis of 4-amino-2',4'-dihydroxyindanone derivatives as potent inhibitors of tyrosinase and melanin biosynthesis in human melanoma cells Leticia Lazinski,Morane Beaumet,Brayan Roulier,Rémy Gay,Guy Royalet al. European Journal of Medicinal Chemistry, 2024, 266, pp.116165. ⟨10.1016/j.ejmech.2024.116165⟩ Article dans une revue hal-04768565v1
Catechol-mimicking transition-state analogues as non-oxidizable inhibitors of tyrosinases Morane Beaumet,Leticia Lazinski,Marc Maresca,Romain Haudecoeur European Journal of Medicinal Chemistry, 2023, 259, pp.115672. ⟨10.1016/j.ejmech.2023.115672⟩ Article dans une revue hal-04768562v1
Resorcinol-based hemiindigoid derivatives as human tyrosinase inhibitors and melanogenesis suppressors in human melanoma cells Brayan Roulier,Inbal Rush,Leticia Lazinski,Basile Pérès,Hamza Olleiket al. European Journal of Medicinal Chemistry, 2023, 246, pp.114972. ⟨10.1016/j.ejmech.2022.114972⟩ Article dans une revue hal-03998028v1
Bioactive Aurones, Indanones, and Other Hemiindigoid Scaffolds: Medicinal Chemistry and Photopharmacology Perspectives Leticia Lazinski,Guy Royal,Maxime Robin,Marc Maresca,Romain Haudecoeur Journal of Medicinal Chemistry, 2022, 65 (19), pp.12594-12625. ⟨10.1021/acs.jmedchem.2c01150⟩ Article dans une revue hal-03826221v1
β-Carboline as a Privileged Scaffold for Multitarget Strategies in Alzheimer's Disease Therapy Aurélien Beato,Anthonin Gori,Benjamin Boucherle,Marine Peuchmaur,Romain Haudecoeur Journal of Medicinal Chemistry, 2021, 64 (3), pp.1392-1422. ⟨10.1021/acs.jmedchem.0c01887⟩ Article dans une revue hal-04020932v1
Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity Lionel Froux,Ahmad Elbahnsi,Benjamin Boucherle,Arnaud Billet,Nesrine Baatallahet al. European Journal of Medicinal Chemistry, 2020, 190, pp.112116. ⟨10.1016/j.ejmech.2020.112116⟩ Article dans une revue hal-02924784v1
Advances in the Design of Genuine Human Tyrosinase Inhibitors for Targeting Melanogenesis and Related Pigmentations Brayan Roulier,Basile Pérès,Romain Haudecoeur Journal of Medicinal Chemistry, 2020, 63 (22), pp.13428-13443. ⟨10.1021/acs.jmedchem.0c00994⟩ Article dans une revue hal-04768552v1
Aurone derivatives as promising antibacterial agents against resistant Gram-positive pathogens Hamza Olleik,Samir Yahiaoui,Brayan Roulier,Elise Courvoisier-Dezord,Josette Perrieret al. European Journal of Medicinal Chemistry, 2019, 165, pp.133-141. ⟨10.1016/j.ejmech.2019.01.022⟩ Article dans une revue hal-01988325v1
Piperidinyl-embeded chalcones possessing anti PI3K delta inhibitory properties exhibit anti-atopic properties in preclinical models Charles Dumontet,Guillaume Beck,Fabrice Gardebien,Romain Haudecoeur,Doriane Maheet al. European Journal of Medicinal Chemistry, 2018, 158, pp.405-413. ⟨10.1016/j.ejmech.2018.09.033⟩ Article dans une revue hal-02621220v1
Traditional uses, phytochemistry and pharmacological properties of African Nauclea species: A review Romain Haudecoeur,Marine Peuchmaur,Basile Pérès,Maxime Rome,Germain Sotoing Taïweet al. Journal of Ethnopharmacology, 2018, 212, pp.106-136. ⟨10.1016/j.jep.2017.10.011⟩ Article dans une revue hal-04019717v1
Glycosyl-Substituted Dicarboxylates as Detergents for the Extraction, Overstabilization, and Crystallization of Membrane Proteins Kim-Anh Nguyen,Marine Peuchmaur,Sandrine Magnard,Romain Haudecoeur,Cédric Boyèreet al. Angewandte Chemie International Edition, 2018, 57 (11), pp.2948-2952. ⟨10.1002/anie.201713395⟩ Article dans une revue hal-02329303v1
2-Hydroxypyridine- N -oxide-Embedded Aurones as Potent Human Tyrosinase Inhibitors Romain Haudecoeur,Marc Carotti,Aurélie Gouron,Marc Maresca,Elina Buitragoet al. ACS Medicinal Chemistry Letters, 2017, 8 (1), pp.55 - 60. ⟨10.1021/acsmedchemlett.6b00369⟩ Article dans une revue hal-01617843v1
Nauclea latifolia: biological activity and alkaloid phytochemistry of a West African tree Benjamin Boucherle,Romain Haudecoeur,Emerson Ferreira Queiroz,Michel de Waard,Jean-Luc Wolfenderet al. Natural Product Reports, 2016, 33 (9), pp.1034-1043. ⟨10.1039/c6np00039h⟩ Article dans une revue hal-02141583v1
Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy? Elina Buitrago,Renaud M Hardré,Romain Haudecoeur,Hélène Jamet,Catherine Belleet al. Current Topics in Medicinal Chemistry, 2016, 16 (27), pp.3033 - 3047. ⟨10.2174/1568026616666160216160112⟩ Article dans une revue istex hal-01644550v1
Recombinant Tyrosinase from Polyporus arcularius : Overproduction in Escherichia coli , Characterization, and Use in a Study of Aurones as Tyrosinase Effectors Eva Marková,Michael Kotik,Alena Křenková,Petr Man,Romain Haudecoeuret al. Journal of Agricultural and Food Chemistry, 2016, 64 (14), pp.2925-2931. ⟨10.1021/acs.jafc.6b00286.s001⟩ Article dans une revue hal-01948810v1
Biomimetic synthesis of Tramadol Florine Lecerf-Schmidt,Romain Haudecoeur,Basile Peres,Marc Ferreira Queiroz,Marc Marcourtet al. Chemical Communications, 2015, 51 (77), pp.14451 - 14453. ⟨10.1039/c5cc05948h⟩ Article dans une revue hal-01683298v1
Synthetic G-Quartets as Versatile Nanotools for the Luminescent Detection of G-Quadruplexes Aurélien Laguerre,Marine Levillain,Loïc Stefan,Romain Haudecoeur,Fares Katranjiet al. CHIMIA International Journal for Chemistry, 2015, 69 (9), pp.530-536. ⟨10.2533/chimia.2015.530⟩ Article dans une revue hal-02125788v1
Investigation of Binding-Site Homology between Mushroom and Bacterial Tyrosinases by Using Aurones as Effectors Romain Haudecoeur,Aurélie Gouron,Carole Dubois,Hélène Jamet,Mark Lightbodyet al. ChemBioChem, 2014, 15 (9), pp.1325 - 1333. ⟨10.1002/cbic.201402003⟩ Article dans une revue istex hal-01652214v1
B-ring modified aurones as promising allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase Amel Meguellati,Abdelhakim Ahmed-Belkacem,Wei Yi,Romain Haudecoeur,Marie Crouillèreet al. European Journal of Medicinal Chemistry, 2014, 80, pp.579-592. ⟨10.1016/j.ejmech.2014.04.005⟩ Article dans une revue hal-04015683v1
Multitasking Water-Soluble Synthetic G-Quartets: From Preferential RNA-Quadruplex Interaction to Biocatalytic Activity Romain Haudecoeur,Loïc Stefan,David Monchaud Chemistry - A European Journal, 2013, 19 (38), pp.12739-12747. ⟨10.1002/chem.201300791⟩ Article dans une revue istex hal-02125745v1
Occurrence of the Synthetic Analgesic Tramadol in an African Medicinal Plant. Ahcène Boumendjel,Germain Sotoing Taïwe,Elisabeth Ngo Bum,Tanguy Chabrol,Chantal Beneyet al. Angewandte Chemie International Edition, 2013, 52 (45), pp.11780-4. ⟨10.1002/anie.201305697⟩ Article dans une revue istex inserm-00874145v1
African tree gets to the root of pain Ahcène Boumendjel,Germain Sotoing Taïwe,Elisabeth Ngo Gum,Tanguy Chabrol,Chantal Beneyet al. Nature, 2013, 501 (7467), pp.285 - 285. ⟨10.1038/501285b⟩ Article dans une revue hal-01683403v1
A Model of Smart G-Quadruplex Ligand Romain Haudecoeur,Loïc Stefan,Franck Denat,David Monchaud Journal of the American Chemical Society, 2012, 135 (2), pp.550-553. ⟨10.1021/ja310056y⟩ Article dans une revue hal-02125742v1
Porphyrin-templated synthetic G-quartet (PorphySQ): a second prototype of G-quartet-based G-quadruplex ligand Hai-Jun Xu,Loïc Stefan,Romain Haudecoeur,Sophie Vuong,Philippe R. Richardet al. Organic & Biomolecular Chemistry, 2012, 10 (27), pp.5212. ⟨10.1039/C2OB25601K⟩ Article dans une revue hal-02125728v1
Discovery of Naturally Occurring Aurones That Are Potent Allosteric Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase. Romain Haudecoeur,Abdelhakim Ahmed-Belkacem,Wei Yi,Antoine Fortuné,Rozenn Brilletet al. Journal of Medicinal Chemistry, 2011, 54 (15), pp.5395-5402. ⟨10.1021/jm200242p⟩ Article dans une revue inserm-00618322v1
Refinement of arylthiosemicarbazone pharmacophore in inhibition of mushroom tyrosinase Wei Yi,Carole Dubois,Samir Yahiaoui,Romain Haudecoeur,Catherine Belleet al. European Journal of Medicinal Chemistry, 2011, 46 (9), pp.4330 - 4335. ⟨10.1016/j.ejmech.2011.07.003⟩ Article dans une revue istex hal-01655567v1

Poster de conférence (7)

Hemiindigos as acetylcholinesterase inhibitors for photopharmacological applications Letícia da Mata Lazinski,Morane Beaumet,Guy Royal,Romain Haudecoeur Journées scientifiques Photosciences 24, May 2024, Grenoble (38000), France Poster de conférence hal-04769182v1
Synthesis and evaluation of the inhibitory activity of resorcinol-based derivatives against tyrosinase and melanin genesis in human melanoma cells Morane Beaumet,Letícia da Mata Lazinski,Brayan Roulier,Marc Maresca,Romain Haudecoeur 31e Journées Jeunes Chercheurs de la Société de Chimie Thérapeutique, Feb 2024, Grenoble (38000), France Poster de conférence hal-04769236v1
Synthesis of hemiindigos as cholinesterase inhibitors for photopharmacological applications Letícia da Mata Lazinski,Morane Beaumet,Guy Royal,Romain Haudecoeur Common scientific days of GDR Solar Fuels and Photo Electro Stimulation, Jun 2024, Grenoble (38000), France Poster de conférence hal-04769148v1
Synthesis of hemiindigos as cholinesterase inhibitors for photopharmacological applications Letícia da Mata Lazinski,Morane Beaumet,Guy Royal,Romain Haudecoeur 20th Congress of the European Society for Photobiology, Aug 2023, Lyon, France Poster de conférence hal-04769166v1
Design and synthesis of inhibitors of tyrosinase and melanin biosynthesis in human melanoma cells Morane Beaumet,Letícia da Mata Lazinski,Brayan Roulier,Marc Maresca,Romain Haudecoeur 5th Scientific day of Grenoble Drug Discovery Club, Nov 2023, Grenoble (38000), France Poster de conférence hal-04769202v1
Synthesis of hemiindigos as cholinesterase inhibitors for photopharmacological applications Letícia da Mata Lazinski,Guy Royal,Romain Haudecoeur Journée Scientifique du Médicament, Jun 2023, Grenoble (38000), France Poster de conférence hal-04769132v1
Nanoliposomal formulations for controlled drug release Núria Pujol-Solé,Letícia da Mata Lazinski,Nazareth Milagros Carigga Gutierrez,Malika Kadri,Tristan Le Claincheet al. 18e Forum de la recherche en cancérologie (CLARA), Apr 2023, Lyon, France Poster de conférence hal-04806805v1

Article de blog scientifique (1)

La lumière, un moyen de contrôler l’effet des médicaments ? Romain Haudecoeur,Letícia da Mata Lazinski,Morane Beaumet 2023 Article de blog scientifique hal-04768583v1

Brevet (2)

Method for synthesizing diversely substituted purines Jean-Luc Decout,Renaud Zelli,Waël Zeinyeh,Benjamin Boucherle,Romain Haudecoeur France, Patent n° : US20210163484A1. 2021 Brevet hal-04768597v1
Compounds for treating cystic fibrosis Isabelle Callebaut,Jean-Paul Mornon,Jean-Luc Decout,F. Becq,Pierre Lehnet al. France, Patent n° : US10414768B2. 2019 Brevet hal-04768593v1

HDR (1)

Outils moléculaires sélectifs pour la détection et la modulation de la tyrosinase humaine et de la mélanogenèse in vivo Romain Haudecoeur Sciences pharmaceutiques. Université Grenoble - Alpes, 2020 HDR tel-04768611v1

Thèse (1)

Pharmacochimie des aurones pour la modulation d'enzymes Romain Haudecoeur Autre. Université de Grenoble; Université de Genève (Genève, Suisse). Faculté des sciences, 2011. Français. ⟨NNT : 2011GRENV063⟩ Thèse tel-00828395v1