Ronan Le Goffic

Identifiants chercheurs

IdHAL :

ronan-le-goffic

ORCID :

0000-0002-2012-0064

IdRef :

061595888

Présentation

Publications

Article dans une revue (59)

Virus‐Induced Cellular Senescence Causes Pulmonary Sequelae Post‐Influenza Infection Larissa Lipskaia,Lou Delval,Valentin Sencio,Emmanuelle Born,Séverine Heumelet al. Aging Cell, 2025, pp.e70140. ⟨10.1111/acel.70140⟩ Article dans une revue hal-05185974v1
Identification of H1N2 influenza viruses in turkeys after spillover from swine and in vitro characterization Chloé Chavoix,Pascale Massin,François-Xavier Briand,Katell Louboutin,Rachel Bussonet al. Virus Research, 2025, 361, pp.199634. ⟨10.1016/j.virusres.2025.199634⟩ Article dans une revue anses-05285166v1
A pan-respiratory virus attachment inhibitor with high potency in human airway models and in vivo Gregory Mathez,Paulo Jacob Silva,Vincent Carlen,Charlotte Deloizy,Clémentine Promptet al. Science Advances , 2025, 11 (31), ⟨10.1126/sciadv.adv9311⟩ Article dans une revue hal-05299974v1
The prion-family protein Doppel exerts a protective role during influenza virus infection Soraya Dinant,Johan Castille,Charlotte Deloizy,Elise Bruder,Laura Sedanoet al. Journal of Immunology, 2025, pp.1-13. ⟨10.1093/jimmun/vkaf031⟩ Article dans une revue hal-05029118v1
Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor Svenja Sake,Xiaoyu Zhang,Manoj Kumar Rajak,Melanie Urbanek-Quaing,Arnaud Carpentieret al. Nature Communications, 2024, 15 (1), pp.1173. ⟨10.1038/s41467-024-45241-y⟩ Article dans une revue hal-04504093v1
An Isolate of Streptococcus mitis Displayed In Vitro Antimicrobial Activity and Deleterious Effect in a Preclinical Model of Lung Infection Elliot Mathieu,Quentin Marquant,Florian Chain,Edwige Bouguyon,Vinciane Saint-Criqet al. Nutrients, 2023, 15 (2), pp. 263. ⟨10.3390/nu15020263⟩ Article dans une revue hal-03943007v1
Comparison of PB1-F2 Proximity Interactomes Reveals Functional Differences between a Human and an Avian Influenza Virus Joëlle Mettier,Clémentine Prompt,Elise Bruder,Bruno da Costa,Christophe Chevalieret al. Viruses, 2023, 15 (2), pp.328. ⟨10.3390/v15020328⟩ Article dans une revue hal-04023221v1
Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion Elisa Franzi,Gregory Mathez,Soraya Dinant,Charlotte Deloizy,Laurent K. Kaiseret al. International Journal of Molecular Sciences, 2023, 24 (20), pp.15382. ⟨10.3390/ijms242015382⟩ Article dans une revue hal-04271263v1
Host succinate inhibits influenza virus infection through succinylation and nuclear retention of the viral nucleoprotein Antoine Guillon,Deborah Bréa-Diakite,Adeline Cezard,Alan Wacquiez,Thomas Baraneket al. EMBO Journal, 2022, 41 (12), pp.e108306. ⟨10.15252/embj.2021108306⟩ Article dans une revue hal-03687124v2
Low Doses of Radiation Increase the Immunosuppressive Profile of Lung Macrophages During Viral Infection and Pneumonia Lydia Meziani,Charlotte Robert,Marion Classe,Bruno da Costa,Michele Mondiniet al. International Journal of Radiation Oncology, Biology, Physics, 2021, 110 (5), pp.1283-1294. ⟨10.1016/j.ijrobp.2021.03.022⟩ Article dans une revue hal-03401860v1
Immunogenicity and Protective Potential of Mucosal Vaccine Formulations Based on Conserved Epitopes of Influenza A Viruses Fused to an Innovative Ring Nanoplatform in Mice and Chickens Cynthia Calzas,Molida Mao,Mathilde Turpaud,Quentin Viboud,Joelle Mettieret al. Frontiers in Immunology, 2021, 12, ⟨10.3389/fimmu.2021.772550⟩ Article dans une revue hal-03575999v1
Influenza viruses and coronaviruses: Knowns, unknowns, and common research challenges Olivier Terrier,Mustapha Si-Tahar,Mariette Ducatez,Christophe Chevalier,Andrés Pizzornoet al. PLoS Pathogens, 2021, 17 (12), pp.e1010106. ⟨10.1371/journal.ppat.1010106⟩ Article dans une revue (article de synthèse) hal-03518306v1
Influenza Virus Infection Impairs the Gut’s Barrier Properties and Favors Secondary Enteric Bacterial Infection through Reduced Production of Short-Chain Fatty Acids Valentin Sencio,Alexandre Gallerand,Marina Gomes Machado,Lucie Deruyter,Séverine Heumelet al. Infection and Immunity, 2021, 89 (9), ⟨10.1128/IAI.00734-20⟩ Article dans une revue inserm-03385672v1
Study of the host specificity of PB1-F2-associated virulence Joëlle Mettier,Daniel Marc,Laura Sedano,Bruno da Costa,Christophe Chevalieret al. Virulence, 2021, 12 (1), pp.1647 - 1660. ⟨10.1080/21505594.2021.1933848⟩ Article dans une revue hal-03264952v1
Self-assembled peptide nanorod vaccine confers protection against influenza A virus Ximena Zottig,Soultan Al-Halifa,Mélanie Côté-Cyr,Cynthia Calzas,Ronan Le Gofficet al. Biomaterials, 2021, 269, ⟨10.1016/j.biomaterials.2021.120672⟩ Article dans une revue hal-03319841v1
PB1-F2 amyloid-like fibers correlate with proinflammatory signaling and respiratory distress in influenza-infected mice Christophe Chevalier,Olivier Leymarie,Laura Sedano,Bruno da Costa,Charles-Adrien Richardet al. Journal of Biological Chemistry, 2021, 297 (1), ⟨10.1016/j.jbc.2021.100885⟩ Article dans une revue hal-03299147v1
A condensate-hardening drug blocks RSV replication in vivo Jennifer Risso-Ballester,Marie Galloux,Jingjing Cao,Ronan Le Goffic,Fortune Hontonnouet al. Nature, 2021, 595 (7868), pp.596 - 599. ⟨10.1038/s41586-021-03703-z⟩ Article dans une revue hal-03318345v1
Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues Asma Ayari,Manuel Rosa-Calatrava,Steve S. Lancel,Johanna Barthelemy,Andrés Pizzornoet al. Communications Biology, 2020, 3 (1), pp.237. ⟨10.1038/s42003-020-0965-6⟩ Article dans une revue hal-02959942v2
Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters Bertrand Bryche,Audrey St Albin,Séverine Murri,Sandra Lacôte,Coralie Pulidoet al. Brain, Behavior, and Immunity, 2020, 89, pp.579-586. ⟨10.1016/j.bbi.2020.06.032⟩ Article dans une revue hal-02984344v1
Targeting the Respiratory Syncytial Virus N 0 -P Complex with Constrained α-Helical Peptides in Cells and Mice Marie Galloux,Nadège Gsponer,Vanessa Gaillard,Brice Fenner,Thibaut Larcheret al. Antimicrobial Agents and Chemotherapy, 2020, 64 (10), ⟨10.1128/AAC.00717-20⟩ Article dans une revue hal-03353101v1
Impact of the influenza protein PB1-F2 on the biochemical composition of human epithelial cells revealed by synchrotron Fourier transform infrared spectromicroscopy Olivier Leymarie,Ronan Le Goffic,Frederic Jamme,Christophe Chevalier Journal of Spectral Imaging, 2020, 8 (18), ⟨10.1255/jsi.2019.a18⟩ Article dans une revue hal-02873862v1
Murine Model for the Study of Influenza D Virus J. Oliva,J. Mettier,L. Sedano,Maxence Delverdier,N. Bourgès-Abellaet al. Journal of Virology, 2020, 94 (4), pp.e01662-19. ⟨10.1128/JVI.01662-19⟩ Article dans une revue hal-02640532v1
Labyrinthopeptins as virolytic inhibitors of respiratory syncytial virus cell entry Sebastian Blockus,Svenja Sake,Martin Wetzke,Christina Grethe,Theresa Graalmannet al. Antiviral Research, 2020, 177, pp.104774. ⟨10.1016/j.antiviral.2020.104774⟩ Article dans une revue hal-02549192v1
Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production Valentin Sencio,Adeline Barthélémy,Luciana Tavares,Marina Machado,Daphnée Soulardet al. Cell Reports, 2020, 30 (9), pp.2934-2947.e6. ⟨10.1016/j.celrep.2020.02.013⟩ Article dans une revue inserm-02501395v1
Respiratory syncytial virus tropism for olfactory sensory neurons in mice Bertrand Bryche,Maxence Fretaud,Audrey Saint‐albin Deliot,Marie Galloux,Laura Sedanoet al. Journal of Neurochemistry, 2020, ⟨10.1111/jnc.14936⟩ Article dans une revue hal-02899462v1
Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection Sandra Axberg Pålsson,Aleksandra Dondalska,Joseph Bergenstråhle,Caroline Rolfes,Albin Björket al. Frontiers in Immunology, 2020, 11, pp.580547. ⟨10.3389/fimmu.2020.580547⟩ Article dans une revue hal-03109137v1
Interleukin-22 Immunotherapy during Severe Influenza Enhances Lung Tissue Integrity and Reduces Secondary Bacterial Systemic Invasion Adeline Barthélémy,Valentin Sencio,Daphnée Soulard,Lucie Deruyter,Christelle Faveeuwet al. Infection and Immunity, 2018, 86 (7), pp.e00706-17. ⟨10.1128/IAI.00706-17⟩ Article dans une revue hal-02398322v1
Humoral Responses Elicited by Adenovirus Displaying Epitopes Are Induced Independently of the Infection Process and Shaped by the Toll-Like Receptor/MyD88 Pathway Aleksandra Anchim,Najat Raddi,Lena Zig,Patrick Perrieau,Ronan Le Gofficet al. Frontiers in Immunology, 2018, 9, pp.1-11. ⟨10.3389/fimmu.2018.00124⟩ Article dans une revue hal-02126585v1
A short double-stapled peptide inhibits respiratory syncytial virus entry and spreading Vanessa Gaillard,Marie Galloux,Dominique Garcin,Jean Francois Eleouet,Ronan Le Gofficet al. Antimicrobial Agents and Chemotherapy, 2017, 61 (4), ⟨10.1128/AAC.02241-16⟩ Article dans une revue hal-01605887v1
Influenza virus protein PB1-F2 interacts with CALCOCO2 (NDP52) to modulate innate immune response Olivier Leymarie,Léa Meyer,Lionel Tafforeau,Vincent Lotteau,Bruno da Costaet al. Journal of General Virology, 2017, 98 (6), pp.1196-1208. ⟨10.1099/jgv.0.000782⟩ Article dans une revue hal-01911416v1
Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism Valeria Cagno,Patrizia Andreozzi,Marco d'Alicarnasso,Paulo Jacob Silva,Marie Muelleret al. Nature Materials, 2017, 17 (2), pp.195-203. ⟨10.1038/NMAT5053⟩ Article dans une revue hal-02629404v1
Transcriptomic profiling of a chicken lung epithelial cell line (CLEC213) reveals a mitochondrial respiratory chain activity boost during influenza virus infection Léa Meyer,Olivier Leymarie,Christophe Chevalier,Evelyne Esnault,Marco Moroldoet al. PLoS ONE, 2017, 12 (4), 18 p. ⟨10.1371/journal.pone.0176355⟩ Article dans une revue hal-01605882v1
Host response comparison of H1N1-and H5N1-infected mice identifies two potential death mechanisms Olivier Leymarie,Léa Meyer,Pierre Louis Herve,Bruno da Costa,Bernard Delmaset al. International Journal of Molecular Sciences, 2017, 18 (8), ⟨10.3390/ijms18081631⟩ Article dans une revue hal-02617657v1
Codon deletions in the influenza a virus pa gene generate temperature-sensitive viruses Léa Meyer,Alix Sausset,Laura Sedano,Bruno B. da Costa,Ronan Le Gofficet al. Journal of Virology, 2016, 90 (7), pp.3684-3693. ⟨10.1128/JVI.03101-15⟩ Article dans une revue hal-02636526v1
The Influenza Virus Protein PB1-F2 Increases Viral Pathogenesis through Neutrophil Recruitment and NK Cells Inhibition Aurore Vidy-Roche,Pauline Maisonnasse,Bruno da Costa,Bernard Delmas,Christophe Chevalieret al. PLoS ONE, 2016, 11 (10), pp.1-19. ⟨10.1371/journal.pone.0165361⟩ Article dans une revue hal-01608535v1
Synchrotron Infrared and Deep UV Fluorescent Microspectroscopy Study of PB1-F2 β-Aggregated Structures in Influenza A Virus-infected Cells Christophe Chevalier,Ronan Le Goffic,Frédéric Jamme,Olivier Leymarie,Matthieu Réfrégierset al. Journal of Biological Chemistry, 2016, 291 (17), pp.9060 - 9072. ⟨10.1074/jbc.M115.710533⟩ Article dans une revue hal-01724147v1
Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases Joan Torrent I Mas,Alba del Valle Vilchez Acosta,Diego Muñoz-Torrero,Marie Trovaslet,Florian Nachonet al. Acta Neuropathologica Communications, 2015, 3 (1), pp.18. ⟨10.1186/s40478-015-0188-0⟩ Article dans une revue inserm-02335432v2
Temperature-sensitive mutants in the influenza A virus RNA polymerase: alterations in the PA linker reduce nuclear targeting of the PB1-PA dimer and result in viral attenuation Bruno B. da Costa,Alix Sausset,Sandie Munier,Alexandre Ghounaris,Nadia Naffakhet al. Journal of Virology, 2015, 89 (12), pp.6376-6390. ⟨10.1128/JVI.00589-15⟩ Article dans une revue hal-02631749v1
Visualizing the replication of respiratory syncytial virus in cells and in living mice Marie-Anne Rameix-Welti,Ronan Le Goffic,Pierre-Louis Hervé,Julien Sourimant,Aude Remotet al. Nature Communications, 2014, 5, ⟨10.1038/ncomms6104⟩ Article dans une revue hal-02633568v1
PB1-F2 attenuates virulence of highly pathogenic avian H5N1 influenza virus in chickens Olivier Leymarie,Carissa Embury-Hyatt,Christophe Chevalier,Luc Jouneau,Marco Moroldoet al. PLoS ONE, 2014, 9 (6), ⟨10.1371/journal.pone.0100679⟩ Article dans une revue hal-01194021v1
Electrochemical Detection of the Oligomerization of PB1-F2 Influenza A Virus Protein in Infected Cells Anna Miodek,Jasmina Vidic,Helene Sauriat-Dorizon,Charles-Adrien Richard,Ronan Le Gofficet al. Analytical Chemistry, 2014, 86 (18), pp.9098 - 9105. ⟨10.1021/ac5018056⟩ Article dans une revue hal-02635306v1
Identification of One Novel Candidate Probiotic Lactobacillus plantarum Strain Active against Influenza Virus Infection in Mice by a Large-Scale Screening Noura N. Kechaou,Florian Chain,Jean-Jacques J.-J. Gratadoux,Sébastien Blugeon,Nicolas N. Berthoet al. Applied and Environmental Microbiology, 2013, 79 (5), pp.1491 - 1499. ⟨10.1128/AEM.03075-12⟩ Article dans une revue hal-01001569v1
Detection of soluble oligomers formed by PB1-F2 influenza A virus protein in vitro Jasmina Vidic,Ronan Le Goffic,Anna Miodek,Christiane Bourdieu,Charles-Adrien Richardet al. Journal of Analytical & Bioanalytical Techniques, 2013, 4 (3), pp.1-2. ⟨10.4172/2155-9872.1000169⟩ Article dans une revue hal-02642907v1
Surface plasmon resonance immunosensor for detection of pb1-f2 influenza a virus protein in infected biological samples Jasmina Vidic,Christophe Chevalier,Ronan Le Goffic,Anna Miodek,Christiane Bourdieuet al. Journal of Analytical & Bioanalytical Techniques, 2013, S7, ⟨10.4172/2155-9872.S7-006⟩ Article dans une revue hal-02642777v1
Kinetic characterization of PB1-F2-mediated immunopathology during highly pathogenic avian H5N1 influenza virus infection. Olivier O. Leymarie,Gregory G. Jouvion,Pierre-Louis P.-L. Hervé,Christophe Chevalier,Valérie V. Lorinet al. PLoS ONE, 2013, 8 (3), pp.e57894. ⟨10.1371/journal.pone.0057894⟩ Article dans une revue hal-01004085v1
Selective antibacterial effects of mixed ZnMgO nanoparticles Jasmina Vidic,Slavica Stankic,Francia Haque,Danica Ciric,Ronan Le Gofficet al. Journal of Nanoparticle Research, 2013, 15 (5), pp.1595. ⟨10.1007/s11051-013-1595-4⟩ Article dans une revue hal-01243099v1
Transcriptomic analysis of host immune and cell death responses associated with the influenza A virus PB1-F2 protein. Ronan Le Goffic,Olivier Leymarie,Christophe Chevalier,Emmanuelle Rebours,Bruno da Costaet al. PLoS Pathogens, 2011, 7 (8), pp.e1002202. ⟨10.1371/journal.ppat.1002202⟩ Article dans une revue hal-00684735v1
Infection with influenza virus induces IL-33 in murine lungs. Ronan Le Goffic,Muhammad Imran Arshad,Michel Rauch,Annie L'Helgoualc'H,Bernard Delmaset al. American Journal of Respiratory Cell and Molecular Biology, 2011, 45 (6), pp.1125-32. ⟨10.1165/rcmb.2010-0516OC⟩ Article dans une revue hal-00681982v1
Influenza A Virus Protein PB1-F2 Exacerbates IFN-b Expression of Human Respiratory Epithelial Cells Ronan Le Goffic,Edwige Bouguyon,Christophe Chevalier,Jasmina Vidic,Bruno da Costaet al. Journal of Immunology, 2010, 185 (8), pp.4812-4823. ⟨10.4049/jimmunol.0903952⟩ Article dans une revue hal-01193647v1
PB1-F2 Influenza A Virus Protein Adopts a beta-Sheet Conformation and Forms Amyloid Fibers in Membrane Environments Christophe Chevalier,Ali Al Bazzal,Jasmina Vidic,Vincent Fevrier,Christiane Bourdieuet al. Journal of Biological Chemistry, 2010, 285 (17), pp.13233-13243. ⟨10.1074/jbc.M109.067710⟩ Article dans une revue hal-02664783v1
Cutting Edge: Influenza A Virus Activates TLR3-Dependent Inflammatory and RIG-I-Dependent Antiviral Responses in Human Lung Epithelial Cells Ronan Le Goffic,Julien Pothlichet,Damien Vitour,Takashi Fujita,Eliane Meurset al. Journal of Immunology, 2007, 178 (6), pp.3368-3372. ⟨10.4049/jimmunol.178.6.3368⟩ Article dans une revue hal-03319510v1
Edema toxin impairs anthracidal phospholipase A2 expression by alveolar macrophages. Benoît Raymond,Dominique Leduc,Lucas Ravaux,Ronan Le Goffic,Thomas Candelaet al. PLoS Pathogens, 2007, 3 (12), pp.e187. ⟨10.1371/journal.ppat.0030187⟩ Article dans une revue pasteur-00317899v1
Detrimental contribution of the Toll-like receptor (TLR) to influenza A virus-induced acute pneumonia Ronan Le Goffic,V. Balloy,M. Lagranderie,L. Alexopoulou,N. Escriouet al. PLoS Pathogens, 2006, 2 (6), pp.e53. ⟨10.1371/journal.ppat.0020053⟩ Article dans une revue hal-00086851v1
Involvement of Toll-like Receptor 3 in the Immune Response of Lung Epithelial Cells to Double-stranded RNA and Influenza A Virus Loïc Guillot,Ronan Le Goffic,Sarah Bloch,Nicolas Escriou,Shizuo Akiraet al. Journal of Biological Chemistry, 2005, 280 (7), pp.5571-5580. ⟨10.1074/jbc.M410592200⟩ Article dans une revue hal-03318968v1
Mumps Virus Decreases Testosterone Production and Gamma Interferon-Induced Protein 10 Secretion by Human Leydig Cells Ronan Le Goffic,Thomas Mouchel,Annick Ruffault,Jean-Jacques Patard,Bernard Jégouet al. Journal of Virology, 2003, 77 (5), pp.3297-3300. ⟨10.1128/jvi.77.5.3297-3300.2003⟩ Article dans une revue hal-03318689v1
Phtf1 Is an Integral Membrane Protein Localized in an Endoplasmic Reticulum Domain in Maturing Male Germ Cells1 J. Oyhenart,Ronan Le Goffic,M. Samson,Bernard Jégou,Natacha Raich Biology of Reproduction, 2003, 68 (3), pp.1044-1053. ⟨10.1095/biolreprod.102.009787⟩ Article dans une revue hal-03318940v1
Spatial, a new nuclear factor tightly regulated during mouse spermatogenesis M. Irla,Denis Puthier,Ronan Le Goffic,G. Victorero,T. Freemanet al. Gene Expression Patterns, 2003, 3 (2), pp.135--138. ⟨10.1016/S1567-133X(03)00024-3⟩ Article dans une revue istex hal-01595826v1
Le virus ourlien et l'orchite : vers une approche physiopathologique Thomas Mouchel,Ronan Le Goffic,Jean-Jacques Patard,Michel Samson Progrès en Urologie, 2002, 12 (1), pp.124-8 Article dans une revue (article de synthèse) hal-03318963v1
Production of the Chemokines Monocyte Chemotactic Protein-1, Regulated on Activation Normal T Cell Expressed and Secreted Protein, Growth-Related Oncogene, and Interferon-γ-Inducible Protein-10 Is Induced by the Sendai Virus in Human and Rat Testicular Cells Ronan Le Goffic,Thomas Mouchel,Florence Aubry,Jean-Jacques Patard,Annick Ruffaultet al. Endocrinology, 2002, 143 (4), pp.1434-1440. ⟨10.1210/endo.143.4.8735⟩ Article dans une revue hal-03318654v1

Pré-publication, Document de travail (1)

Cis-aconitate therapy protects against influenza mortality by dual targeting of viral polymerase and ERK/AKT/NF-κB signaling Adeline Cezard,Déborah Brea-Diakite,Virginie Vasseur,Alan Wacquiez,Loïc Gonzalezet al. 2025 Pré-publication, Document de travail (preprint/prepublication) hal-05375838v1