Ruben Hartkoorn

Publications

Article dans une revue (21)

Pyridylpiperazine efflux pump inhibitor boosts in vivo antibiotic efficacy against K. pneumoniae Anais Vieira da Cruz,Juan-Carlos Jiménez-Castellanos,Clara Börnsen,Laurye van Maele,Nina Compagneet al. EMBO Molecular Medicine, 2023, 16 (1), pp.93-111. ⟨10.1038/s44321-023-00007-9⟩ Article dans une revue hal-04397794v1
Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative Bacteria Nina Compagne,Anais Vieira da Cruz,Reinke Müller,Ruben C. Hartkoorn,Marion Flipoet al. Antibiotics, 2023, 12 (1), pp.180. ⟨10.3390/antibiotics12010180⟩ Article dans une revue (article de synthèse) hal-03970073v1
Characterization of pyridylpiperazine-based efflux pump inhibitors for Acinetobacter baumannii Juan-Carlos Jiménez-Castellanos,Elizabeth Pradel,Nina Compagne,Anais Vieira da Cruz,Marion Flipoet al. JAC-Antimicrobial Resistance, 2023, 5 (5), pp.2138-2149. ⟨10.1093/jacamr/dlad112⟩ Article dans une revue hal-04397896v1
Optimization of pyridylpiperazine-based inhibitors of the Escherichia coli AcrAB-TolC efflux pump Nina Compagne,Juan-Carlos Jiménez-Castellanos,Virginie Meurillon,Elizabeth Pradel,Anais Vieira da Cruzet al. European Journal of Medicinal Chemistry, 2023, 259, pp.115630. ⟨10.1016/j.ejmech.2023.115630⟩ Article dans une revue hal-04165261v1
A Novel Natural Siderophore Antibiotic Conjugate Reveals a Chemical Approach to Macromolecule Coupling Thibault Caradec,Ernesto Anoz-Carbonell,Ravil Petrov,Muriel Billamboz,Kevin Antraygueset al. ACS Central Science, 2023, 9 (11), pp.2138-2149. ⟨10.1021/acscentsci.3c00965⟩ Article dans une revue hal-04444864v1
2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1 Vladimir Finger,Tomas Kucera,Radka Kafkova,Lubica Muckova,Rafael Dolezalet al. European Journal of Medicinal Chemistry, 2023, 258, pp.115611. ⟨10.1016/j.ejmech.2023.115611⟩ Article dans une revue hal-04465147v1
Regioselective and Stereoselective Synthesis of Parthenolide Analogs by Acyl Nitroso-Ene Reaction and Their Biological Evaluation against Mycobacterium tuberculosis Bruna Gioia,Francesca Ruggieri,Alexandre Biela,Valérie Landry,Pascal Rousselet al. International Journal of Molecular Sciences, 2023, 24 (24), pp.17395. ⟨10.3390/ijms242417395⟩ Article dans une revue hal-04339224v1
Dactylosporolides: Glycosylated Macrolides from Dactylosporangium fulvum Thibault Caradec,Xavier Trivelli,Eva Desmecht,Veronique Peucelle,Ruben Christiaan Hartkoornet al. Journal of Natural Products, 2022, 85 (12), pp.2714-2722. ⟨10.1021/acs.jnatprod.2c00484⟩ Article dans une revue hal-04464884v1
Tricyclic SpiroLactams Kill Mycobacteria In Vitro and In Vivo by Inhibiting Type II NADH Dehydrogenases Sushovan Dam,Salia Tangara,Claire Hamela,Theo Hattabi,Léo Faïonet al. Journal of Medicinal Chemistry, 2022, 65 (24), pp.16651-16664. ⟨10.1021/acs.jmedchem.2c01493⟩ Article dans une revue hal-04017354v1
Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps Coline Plé,Heng-Keat Tam,Anais Vieira da Cruz,Nina Compagne,Juan-Carlos Jiménez-Castellanoset al. Nature Communications, 2022, 13 (1), pp.115. ⟨10.1038/s41467-021-27726-2⟩ Article dans une revue hal-03521512v1
Rubrolone production by Dactylosporangium vinaceum: biosynthesis, modulation and possible biological function Sophie Moureu,Thibault Caradec,Xavier Trivelli,Hervé Drobecq,Delphine Beuryet al. Applied Microbiology and Biotechnology, 2021, 105 (13), pp.5541-5551. ⟨10.1007/s00253-021-11404-w⟩ Article dans une revue hal-03360998v1
Intragenic Distribution of IS 6110 in Clinical Mycobacterium tuberculosis Strains: Bioinformatic Evidence for Gene Disruption Leading to Underdiagnosed Antibiotic Resistance Rudy Antoine,Cyril Gaudin,Ruben Christiaan Hartkoorn Microbiology Spectrum, 2021, 9 (1), ⟨10.1128/Spectrum.00019-21⟩ Article dans une revue hal-04462804v1
Synthesis and Structure–Activity Relationship Studies of C2-Modified Analogs of the Antimycobacterial Natural Product Pyridomycin Maryline Kienle,Patrick Eisenring,Barbara Stoessel,Oliver Horlacher,Samuel Hasleret al. Journal of Medicinal Chemistry, 2020, 63 (3), pp.1105-1131. ⟨10.1021/acs.jmedchem.9b01457⟩ Article dans une revue hal-04462810v1
Pyrrolomycins Are Potent Natural Protonophores Katherine Valderrama,Elizabeth Pradel,Alexander M. Firsov,Hervé Drobecq,Hélène Bauderlique-Le Royet al. Antimicrobial Agents and Chemotherapy, 2019, 63 (10), pp.e01450-19. ⟨10.1128/AAC.01450-19⟩ Article dans une revue hal-03361019v1
Total Synthesis of Ripostatin B and Structure–Activity Relationship Studies on Ripostatin Analogs Florian Glaus,Darija Dedić,Priyanka Tare,Valakunja Nagaraja,Liliana Rodrigueset al. Journal of Organic Chemistry, 2018, 83 (13), pp.7150-7172. ⟨10.1021/acs.joc.8b00193⟩ Article dans une revue hal-04462820v1
Accelerated microfluidic native chemical ligation at difficult amino acids toward cyclic peptides Nathalie Ollivier,Thomas Toupy,Ruben Hartkoorn,Rémi Desmet,Jean-Christophe Monbaliuet al. Nature Communications, 2018, 9 (1), pp.2847. ⟨10.1038/s41467-018-05264-8⟩ Article dans une revue hal-02133846v1
Characterization of new, efficient Mycobacterium tuberculosis topoisomerase-I inhibitors and their interaction with human ABC multidrug transporters Csilla Temesszentandrási-Ambrus,Szilárd Tóth,Rinkee Verma,Péter Bánhegyi,István Szabadkaiet al. PLoS ONE, 2018, 13 (9), pp.e0202749. ⟨10.1371/journal.pone.0202749⟩ Article dans une revue hal-04462816v1
A druggable secretory protein maturase of Toxoplasma essential for invasion and egress Sunil Kumar Dogga,Budhaditya Mukherjee,Damien Jacot,Tobias Kockmann,Luca Molinoet al. eLife, 2017, 6, ⟨10.7554/eLife.27480⟩ Article dans une revue hal-04462826v1
Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis Lijiang Song,Matthew Jenner,Joleen Masschelein,Cerith Jones,Matthew Bullet al. Journal of the American Chemical Society, 2017, 139 (23), pp.7974-7981. ⟨10.1021/jacs.7b03382⟩ Article dans une revue hal-04462832v1
MoS2/TiO2/SiNW surface as an effective substrate for LDI-MS detection of glucose and glutathione in real samples Abderrahmane Hamdi,Ioana Silvia Hosu,Ahmed Addad,Ruben Hartkoorn,Hervé Drobecqet al. Talanta, 2017, 171, pp.101-107. ⟨10.1016/j.talanta.2017.04.061⟩ Article dans une revue hal-02133897v1
Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG Giorgia Mori,Laurent Chiarelli,Marta Esposito,Vadim Makarov,Marco Bellinzoniet al. Chemistry and Biology, 2015, 22 (7), pp.917-927. ⟨10.1016/j.chembiol.2015.05.016⟩ Article dans une revue pasteur-03096090v1

Brevet (2)

Hydrazide derivatives and their specific use as antibacterial agents by controlling acinetobacter baumannii bacterium Anca-Elena Dascalu,Muriel Rouleau Billamboz,Alina Guinet,Benoît Rigo,Emmanuelle Lipkaet al. France, Patent n° : WO2020169682A1. 2020 Brevet hal-04494883v1
Hydrazonopyrrolidine derivatives for use in preventing and/or treating disorders associated to acinetobacter baumannii Anca-Elena Dascalu,Muriel Rouleau Billamboz,Alina Guinet,Benoît Rigo,Emmanuelle Lipkaet al. France, Patent n° : WO2020169683A1. 2020 Brevet hal-04494880v1