Sandrine BETUING

Publications

Article dans une revue (33)

Nuclear Calcium Signaling in D1 Receptor–Expressing Neurons of the Nucleus Accumbens Regulates Molecular, Cellular, and Behavioral Adaptations to Cocaine Estefani Saint-Jour,Marie-Charlotte Allichon,Andry Andrianarivelo,Enrica Montalban,Claire Martinet al. Biological Psychiatry, 2025, 98 (1), pp.34-45. ⟨10.1016/j.biopsych.2025.01.013⟩ Article dans une revue hal-05361412v1
Cell-Type Specific Regulation of Cholesterogenesis by CYP46A1 Re-Expression in zQ175 HD Mouse Striatum Katleen Pinchaud,Chloé Masson,Baptiste Dayre,Coline Mounier,Jean-François Gilleset al. International Journal of Molecular Sciences, 2023, 24 (13), pp.11001. ⟨10.3390/ijms241311001⟩ Article dans une revue hal-04177288v2
Altered Cholesterol Homeostasis in Huntington’s Disease Radhia Kacher,Coline Mounier,Jocelyne Caboche,Sandrine Betuing Frontiers in Aging Neuroscience, 2022, 14, pp.797220. ⟨10.3389/fnagi.2022.797220⟩ Article dans une revue hal-03818923v1
Editorial: Cholesterol and Neurodegenerative Diseases - Pressing Questions and How to Address Them Sandrine Betuing,Irina A Pikuleva,Joseph M Castellano Frontiers in Aging Neuroscience, 2022, 14, pp.948153. ⟨10.3389/fnagi.2022.948153⟩ Article dans une revue hal-03941798v1
Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine's rewarding effects but preserves natural reward processing Andry Andrianarivelo,Estefani Saint-Jour,Paula Pousinha,Sebastian P Fernandez,Anna Petitbonet al. Science Advances , 2021, 7, pp.1-17. ⟨10.1126/sciadv.abg5970⟩ Article dans une revue hal-03389497v1
Identification of First-in-Class Inhibitors of Kallikrein-Related Peptidase 6 That Promote Oligodendrocyte Differentiation Sabrina Aït Amiri,Cyrille Deboux,Feryel Soualmia,Nancy Chaaya,Maxime Louetet al. Journal of Medicinal Chemistry, 2021, 64 (9), pp. 5667-5688. ⟨10.1021/acs.jmedchem.0c02175⟩ Article dans une revue hal-03281511v1
The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease Clévio Nóbrega,André Conceição,Rafael G Costa,Rebekah Koppenol,Raquel L Sequeiraet al. BMC Research Notes, 2020, 13, pp.210. ⟨10.1186/s13104-020-05053-x⟩ Article dans une revue hal-03053649v1
Rétablir le métabolisme cérébral du cholestérol est neuro-protecteur dans la maladie de Huntington Jocelyne Caboche,Radhia Kacher,Sandrine Betuing Médecine/Sciences, 2020, 36, pp.12 - 15. ⟨10.1051/medsci/2019253⟩ Article dans une revue hal-03053633v1
CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington’s disease Radhia Kacher,Antonin Lamazière,Nicolas Heck,Vincent Kappes,Coline Mounieret al. Brain - A Journal of Neurology , 2019, 142 (8), pp.2432-2450. ⟨10.1093/brain/awz174⟩ Article dans une revue hal-03429397v1
CYP46A1 protects against NMDA-mediated excitotoxicity in Huntington's disease: Analysis of lipid raft content Lydie Boussicault,Radhia Kacher,Antonin Lamaziere,Peter Vanhoutte,Jocelyne Cabocheet al. Biochimie, 2018, 153, pp.70-79. ⟨10.1016/j.biochi.2018.07.019⟩ Article dans une revue hal-02350678v1
Rapid synaptogenesis in the Nucleus Accumbens is induced by a single cocaine administration and stabilized by MAP Kinase interacting kinase 1 activity Marc dos Santos,Marine Salery,Benoit Forget,Maria Alexandra Garcia Perez,Sandrine Betuinget al. Biological Psychiatry, 2017, 82 (11), pp.806-818. ⟨10.1016/j.biopsych.2017.03.014⟩ Article dans une revue hal-01500913v1
Rapid Synaptogenesis in the Nucleus Accumbens Is Induced by a Single Cocaine Administration and Stabilized by Mitogen-Activated Protein Kinase Interacting Kinase-1 Activity Jocelyne Caboche,Marc Dos Santos,Marine Salery,Benoit Forget,Maria Alexandraet al. Biological Psychiatry, 2017, 82 (11), pp.806-818. ⟨10.1016/j.biopsych.2017.03.014⟩ Article dans une revue hal-03365856v1
CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease Lydie Boussicault,Sandro Alves,Antonin Lamazière,Anabelle Planques,Nicolas Hecket al. Brain - A Journal of Neurology , 2016, 139 (3), pp.953-970. ⟨10.1093/brain/awv384⟩ Article dans une revue hal-01299208v1
Coupling of D2R Short but not D2R Long receptor isoform to the Rho/ROCK signaling pathway renders striatal neurons vulnerable to mutant huntingtin Beatriz Galan-Rodriguez,Elodie Martin,Emmanuel Brouillet,Nicole Déglon,Sandrine Betuinget al. European Journal of Neuroscience, 2016, 45 (1), pp.198-206. ⟨10.1111/ejn.13415⟩ Article dans une revue hal-01396567v1
AAV-CYP46A1 brain administration restores cholesterol metabolism and is neuroprotective in Huntington's disease N. Cartier,L. Boussicault,S. Alves,R. Kacher,A. Lamaziereet al. Human Gene Therapy, 2016, 27 (11), pp.A24 Article dans une revue hal-01536676v1
BENEFICIAL EFFECTS OF STRIATAL RESTORATION OF CYP46A1 EXPRESSION ON CHOLESTEROL METABOLISM AND NEURODEGENERATION IN HUNTINGTON'S DISEASE MOUSE MODEL (R6/2) S. Betuing,A. Planques,L. Moumne,A. Lamazieres,L. Boussicaultet al. Journal of Neurology, Neurosurgery and Psychiatry, 2014, 85 (1), pp.A17-A18. ⟨10.1136/jnnp-2014-309032.53⟩ Article dans une revue hal-01541327v1
B16 Mitogen And Stress-activated Kinase-1 Deficiency And Transcriptional Dysregulation In Huntington’s Disease L. Moumne,K. Brami-Cherrier,S. Betuing,S. Le Crom,J. Giraultet al. Journal of Neurology, Neurosurgery and Psychiatry, 2014, 85 (1), pp.A14. ⟨10.1136/jnnp-2014-309032.44⟩ Article dans une revue hal-01541325v1
Multiple aspects of gene dysregulation Huntington's disease Jocelyne Caboche,Lara Moumne,Sandrine Betuing Frontiers in Neurology, 2013, 4, pp.127. ⟨10.3389/fneur.2013.00127⟩ Article dans une revue hal-01541330v1
Mitogen and Stress-activated Kinase-1 deficiency and transcriptional dysregulation in Huntington's Disease Lara Moumne,Karen Brami-Cherrier,Sandrine Betuing,Elodie Martin,Stephane Le Cromet al. Human Gene Therapy, 2012, 23 (10), pp.A72-A73 Article dans une revue hal-01541335v1
A deconvolution method to improve automated 3D-analysis of dendritic spines: application to a mouse model of Huntington's disease Nicolas Heck,Sandrine Betuing,Peter Vanhoutte,Jocelyne Caboche Brain Structure and Function, 2012, 217 (2), pp.421-434. ⟨10.1007/s00429-011-0340-y⟩ Article dans une revue istex hal-01541333v1
Beneficial effects of striatal restoration of CYP46A1 expression using AAVrh10 serotype in Huntington's disease mice model (R6/2) Anabelle Planques,Amelie Hu,Francoise Piguet,Lara Moumne,Fathia Djeltiet al. Human Gene Therapy, 2012, 23 (10), pp.A73 Article dans une revue hal-01541336v1
A deconvolution method to improve automated 3D-analysis of dendritic spines: application to a mouse model of Huntington’s disease Nicolas Heck,Sandrine Betuing,Peter Vanhoutte,Jocelyne Caboche Brain Structure and Function, 2012, 217 (2), pp.421-434. ⟨10.1007/s00429-011-0340-y⟩ Article dans une revue istex hal-02372594v1
Axon diodes for the reconstruction of oriented neuronal networks in microfluidic chambers Jean-Michel Peyrin,Bérangère Deleglise,Laure Saias,Maeva Vignes,Paul Gougiset al. Lab on a Chip, 2011, 11 (21), pp.3663. ⟨10.1039/c1lc20014c⟩ Article dans une revue hal-02372610v1
Role of the ERK/MSK1 signalling pathway in chromatin remodelling and brain responses to drugs of abuse. Karen Brami-Cherrier,Emmanuel Roze,Jean-Antoine Girault,Sandrine Betuing,Jocelyne Caboche Journal of Neurochemistry, 2009, 108 (6), pp.1323-35. ⟨10.1111/j.1471-4159.2009.05879.x⟩ Article dans une revue hal-00407701v1
[Pathophysiology of Huntington's disease: an update] E. Roze,S. Betuing,C. Deyts,M. Vidailhet,J. Caboche Revue Neurologique, 2008, 164 (12), pp.977-94. ⟨10.1016/j.neurol.2008.03.006⟩ Article dans une revue hal-00407690v1
Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death Emmanuel Roze,Sandrine Betuing,Carole Deyts,Estelle Marcon,Karen Brami-Cherrieret al. FASEB Journal, 2008, 22 (4), pp.1083-1093. ⟨10.1096/fj.07-9814⟩ Article dans une revue hal-00258860v1
Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo. Delphine Charvin,Emmanuel Roze,Valérie Perrin,Carole Deyts,Sandrine Betuinget al. Neurobiology of Disease, 2007, 29 (1), pp.22-29. ⟨10.1016/j.nbd.2007.07.028⟩ Article dans une revue hal-00181915v1
Mutations of SPG4 are responsible for a loss of function of spastin, an abundant neuronal protéine localized in the nucleus. D. Charvin,C. Cifuentes-Diaz,Nuria Fonknechten,V. Joshi,J. Hazanet al. Human Molecular Genetics, 2003, 12, pp.71-78. ⟨10.1093/hmg/ddg004⟩ Article dans une revue hal-00079650v1
Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression Darrell Belke,Sandrine Betuing,Martin Tuttle,Christophe Graveleau,Martin Younget al. Journal of Clinical Investigation, 2002, 109 (5), pp.629-639. ⟨10.1172/JCI13946⟩ Article dans une revue hal-03941833v1
Gbeta gamma-independent coupling of alpha2-adrenergic receptor to p21(rhoA) in preadipocytes. Sandrine Bétuing,Danièle Daviaud,Céline Pagès,Elisabeth Bonnard,Philippe Valetet al. Journal of Biological Chemistry, 1998, 273 (25), pp.15804-10 Article dans une revue inserm-00110175v1
Regulation of Fat-Cell Function by α2-Adrenergic Receptors M. Lafontan,S. Betuing,J-S. Saulnier-Blache,P. Valet,A. Bouloumiéet al. Adv Phamacol, 1997, Advances in Pharmacology, 42, pp.496-498. ⟨10.1016/s1054-3589(08)60797-8⟩ Article dans une revue hal-03941816v1
Functional Consequences of Constitutively Active α2A-Adrenergic Receptor Expression in 3T3F442A Preadipocytes and Adipocytes Sandrine Bétuing,Philippe Valet,Sophie Lapalu,Delphine Peyroulan,Gilles Hicksonet al. Biochemical and Biophysical Research Communications, 1997, 235 (3), pp.765-773. ⟨10.1006/bbrc.1997.6887⟩ Article dans une revue istex hal-03941822v1
alpha2-Adrenoceptor stimulation promotes actin polymerization and focal adhesion in 3T3F442A and BFC-1beta preadipocytes. S Bétuing,D Daviaud,P Valet,A Bouloumié,M Lafontanet al. Endocrinology, 1996, 137 (12), pp.5220-5229. ⟨10.1210/endo.137.12.8940338⟩ Article dans une revue hal-03941827v1

Communication dans un congrès (5)

Liver X Receptor activation is associated with behavioural and neuropathological improvements in Huntington’s disease Sandrine Betuing European Network of Oxysteral Meeting, Sep 2023, Toulouse, France Communication dans un congrès hal-04299227v1
Liver X Receptor signaling in the striatum and neuroprotection in Huntington’s Disease Sandrine Betuing European Huntington's disease Network meeting, Sep 2021, Bologna (ITALY), Italy Communication dans un congrès hal-04299188v1
Striatal regulation of cholesterol metabolism by cyp46a1 is associated with multiple benefits in Huntington’s disease knock-in mice models Sandrine Betuing Mediterranean Neuroscience Society Meeting, Jun 2019, Marrachech, Morocco Communication dans un congrès hal-04299193v1
Cholesterol metabolism alteration in Huntington's disease Sandrine Betuing CHDI meeting, Nov 2018, Boston (MA), United States Communication dans un congrès hal-04299209v1
CYP46A1 restores cholesterol metabolism in zQ175 mice model of Huntington’s disease Sandrine Betuing European Network of Oxysterol Meeting, Sep 2017, Brussel, Belgium Communication dans un congrès hal-04299199v1

Chapitre d'ouvrage (1)

Cellular and Molecular Mechanisms of Neuronal Dysfunction in Huntington's Disease J. Caboche,P. Vanhoutte,L. Boussicault,E. Roze,S. Betuing Handbook of basal ganglia Structure and function, pp.889-906, 2016, ⟨10.1016/B978-0-12-802206-1.00045-3⟩ Chapitre d'ouvrage hal-02372748v1