Sandrine Silvente-Poirot Research Director (DR1) at CNRSCo-head of Team INOV &quot;Cholesterol Metabolism and Therapeutic Innovations&quot;Cancer Research Center of Toulouse, CRCT, UMR1037, UMR5071

Publications

Article dans une revue (83)

Selective DHCR7 inhibition versus AEBS modulation: Mechanistic implications for tamoxifen effects in AML Marc Poirot,Philippe de Medina,Sandrine Silvente‐poirot British Journal of Haematology, 2026, Online ahead of print. ⟨10.1111/bjh.70420⟩ Article dans une revue inserm-05553796v1
The Phospholipid Bis(monoacylglycero)Phosphate Confers Antitumour Immunogenicity to Exosomes Secreted by Dendrogenin A, Which Activates Its Biosynthesis in Tumour Cells Julio Buñay,Michel Record,Philippe de Medina,Silia Ayadi,Laly Pucheuet al. Journal of Extracellular Vesicles, 2026, 15 (2), pp.e70225. ⟨10.1002/jev2.70225⟩ Article dans une revue inserm-05495718v1
Oxysterols at the Crossroads of Cholesterol Metabolism and Cancer Julio Buñay,Silia Ayadi,Chloe Gressein,Philippe de Medina,Sandrine Silvente-Poirotet al. Seminars in Cancer Biology, 2026, Online ahead of print. ⟨10.1016/j.semcancer.2026.03.001⟩ Article dans une revue inserm-05553790v1
Liver X receptors and the hallmarks of aging: From molecular mechanisms to therapeutic opportunities Marc Poirot,Julio Buñay,Silia Ayadi,Sandrine Silvente-Poirot,Philippe de Medina Ageing Research Reviews - ARR, 2026, 114, pp.102967. ⟨10.1016/j.arr.2025.102967⟩ Article dans une revue inserm-05394944v1
Chemical synthesis and biochemical properties of cholestane-5α,6β-diol-3-sulfonate: A non-hydrolysable analogue of cholestane-5α,6β-diol-3β-sulfate Philippe de Medina,Silia Ayadi,Régis Soulès,Bruno Payre,Sandrine Rup-Jacqueset al. Journal of Steroid Biochemistry and Molecular Biology, 2023, 234, pp.106396. ⟨10.1016/j.jsbmb.2023.106396⟩ Article dans une revue hal-04509731v1
Is cholesterol a risk factor for breast cancer incidence and outcome? Céline Ben Hassen,Caroline Goupille,Claire Vigor,Thierry Durand,Françoise Guéraudet al. Journal of Steroid Biochemistry and Molecular Biology, 2023, 232, pp.106346. ⟨10.1016/j.jsbmb.2023.106346⟩ Article dans une revue hal-04165228v1
27-hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor Silia Ayadi,Silvia Friedrichs,Regis Soulès,Laly Pucheu,Dieter Lütjohannet al. Journal of Lipid Research, In press, 64 (12), pp.100479. ⟨10.1016/j.jlr.2023.100479⟩ Article dans une revue inserm-04317313v1
Oxysterols are potential physiological regulators of ageing Philippe de Medina,Sandrine Silvente-Poirot,Marc Poirot Ageing Research Reviews - ARR, 2022, 77, pp.101615. ⟨10.1016/j.arr.2022.101615⟩ Article dans une revue inserm-03629546v1
Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome‐enriched vesicles Michel Record,Mehdi Attia,Kevin Carayon,Laly Pucheu,Julio Bunayet al. Journal of Extracellular Vesicles, 2022, 11 (4), pp.e12211. ⟨10.1002/jev2.12211⟩ Article dans une revue inserm-03649213v1
Targeting NR1H/liver X receptor with dendrogenin A differentiates tumor cells to activate a new secretory pathway releasing immunogenic anti-tumor vesicles enriched in LC3-II-associated exosomes Philippe de Medina,Julio Bunay,Marc Poirot,Michel Record,Sandrine Silvente-Poirot Autophagy, 2022, 19 (3), pp.1036-1038. ⟨10.1080/15548627.2022.2116175⟩ Article dans une revue inserm-03854248v1
Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti–PD-1 Therapy Efficacy Anne Montfort,Florie Bertrand,Julia Rochotte,Julia Gilhodes,Thomas Filleronet al. Cancer Immunology Research, 2021, 9 (5), pp.568-582. ⟨10.1158/2326-6066.CIR-20-0342⟩ Article dans une revue inserm-03402255v1
The 5,6‐epoxycholesterol metabolic pathway in breast cancer: Emergence of new pharmacological targets Philippe Medina,Khadijetou Diallo,Emilie Huc‐claustre,Mehdi Attia,Régis Soulèset al. British Journal of Pharmacology, 2021, 178 (16), pp.3248-3260. ⟨10.1111/bph.15205⟩ Article dans une revue inserm-03394464v1
The 5,6-epoxycholesterol metabolic pathway in cancer: emergence of new pharmacological targets Philippe de Médina,Khadijetou Diallo,Emilie Huc Claustre,Mehdi Attia,Régis Soulèset al. British Journal of Pharmacology, 2020, 178 (16), pp.3248-3260. ⟨10.22541/au.159069407.75369904⟩ Article dans une revue inserm-03086999v1
Dendrogenin A Enhances Anti-Leukemic Effect of Anthracycline in Acute Myeloid Leukemia Pierre-Luc Mouchel,Nizar Serhan,Rémy Bétous,Thomas Farge,Estelle Salandet al. Cancers, 2020, 12 (10), pp.2933. ⟨10.3390/cancers12102933⟩ Article dans une revue inserm-03084630v1
Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo Nizar Serhan,Pierre-Luc Mouchel,Philippe de Médina,Gregory Segala,Aurélie Mougelet al. Cancers, 2020, 12 (7), pp.1725. ⟨10.3390/cancers12071725⟩ Article dans une revue inserm-03084638v1
The 5,6‐epoxycholesterol metabolic pathway in breast cancer: Emergence of new pharmacological targets Philippe Medina,Khadijetou Diallo,Emilie Huc‐claustre,Mehdi Attia,Régis Soulèset al. British Journal of Pharmacology, 2020, Online ahead of print. ⟨10.1111/bph.15205⟩ Article dans une revue inserm-03084636v1
Natural and semisynthetic oxyprenylated aromatic compounds as stimulators or inhibitors of melanogenesis Salvatore Genovese,Francesco Epifano,Philippe de Médina,Nicolas Caron,Arnaud Riveset al. Bioorganic Chemistry, 2019, 87, pp.181-190. ⟨10.1016/j.bioorg.2019.03.026⟩ Article dans une revue inserm-02380542v1
Oxysterols: An expanding family of structurally diversified bioactive steroids Marc Poirot,Sandrine Silvente-Poirot Journal of Steroid Biochemistry and Molecular Biology, 2019, 194, pp.105443. ⟨10.1016/j.jsbmb.2019.105443⟩ Article dans une revue inserm-02380490v1
HPLC Analysis and Skin Whitening Effects of Umbelliprenin-containing Extracts of Anethum Graveolens, Pimpinella Anisum, and Ferulago Campestris Vito Taddeo,Francesco Epifano,Francesca Preziuso,Serena Fiorito,Nicolas Caronet al. Molecules, 2019, 24 (3), pp.501. ⟨10.3390/molecules24030501⟩ Article dans une revue inserm-02380544v1
A fast UPLC–HILIC method for an accurate quantiﬁcation of dendrogenin A in human tissues Régis Soules,Fabien Audouard-Combe,Emilie Huc-Claustre,Philippe de Médina,Arnaud Riveset al. Journal of Steroid Biochemistry and Molecular Biology, 2019, 194, pp.105447. ⟨10.1016/j.jsbmb.2019.105447⟩ Article dans une revue istex inserm-02380526v1
Flavonoids differentially modulate liver X receptors activity—Structure-function relationship analysis Allan Fouache,Nada Zabaiou,Cyrille de Joussineau,Laurent Morel,Sandrine Silvente-Poirotet al. Journal of Steroid Biochemistry and Molecular Biology, 2019, 190, pp.173-182. ⟨10.1016/j.jsbmb.2019.03.028⟩ Article dans une revue inserm-02380571v1
The cholesterol-derived metabolite dendrogenin A functionally reprograms breast adenocarcinoma and undifferentiated thyroid cancer cells Mathilde Bauriaud-Mallet,Lavinia Vija-Racaru,Séverine Brillouet,Arnaud Mallinger,Philippe de Médinaet al. Journal of Steroid Biochemistry and Molecular Biology, 2019, 192, pp.105390. ⟨10.1016/j.jsbmb.2019.105390⟩ Article dans une revue inserm-02380538v1
Chemistry, biochemistry, metabolic fate and mechanism of action of 6-oxo-cholestan-3β,5α-diol (OCDO), a tumor promoter and cholesterol metabolite Marc Poirot,Régis Soules,Arnaud Mallinger,Florence Dalenc,Sandrine Silvente-Poirot Biochimie, 2018, 153, pp.139-149. ⟨10.1016/j.biochi.2018.04.008⟩ Article dans une revue inserm-02380564v1
The tumor-suppressor cholesterol metabolite, dendrogenin A, is a new class of LXR modulator activating lethal autophagy in cancers Sandrine Silvente-Poirot,Marc Poirot Biochemical Pharmacology, 2018, 153, pp.75-81. ⟨10.1016/j.bcp.2018.01.046⟩ Article dans une revue inserm-02380575v1
The Effects of Cholesterol-Derived Oncometabolites on Nuclear Receptor Function in Cancer Sandrine Silvente-Poirot,Florence Dalenc,Marc Poirot Cancer Research, 2018, 78 (17), pp.4803-4808. ⟨10.1158/0008-5472.CAN-18-1487⟩ Article dans une revue inserm-02380586v1
Extracellular vesicles: lipids as key components of their biogenesis and functions Michel Record,Sandrine Silvente-Poirot,Marc Poirot,Michael J. O. Wakelam Journal of Lipid Research, 2018, 59 (8), pp.1316-1324. ⟨10.1194/jlr.E086173⟩ Article dans une revue inserm-02380557v1
Ligand-dependent transcriptional induction of lethal autophagy: A new perspective for cancer treatment Sandrine Silvente-Poirot,Gregory Segala,Mathias Poirot,Marc Poirot Autophagy, 2018, 14 (3), pp.555-557. ⟨10.1080/15548627.2018.1425059⟩ Article dans une revue inserm-02380583v1
Bryonolic Acid Blocks Cancer Cell Clonogenicity and Invasiveness through the Inhibition of Fatty Acid: Cholesteryl Ester Formation Farid Khallouki,Robert Owen,Sandrine Silvente-Poirot,Marc Poirot Biomedicines, 2018, 6 (1), pp.21. ⟨10.3390/biomedicines6010021⟩ Article dans une revue inserm-02380570v1
Circulating oxysterol metabolites as potential new surrogate markers in patients with hormone receptor-positive breast cancer: Results of the OXYTAM study Florence Dalenc,Luiggi Iuliano,Thomas Filleron,Chiara Zerbinati,Maud Voisinet al. Journal of Steroid Biochemistry and Molecular Biology, 2017, 169, pp.210-218. ⟨10.1016/j.jsbmb.2016.06.010⟩ Article dans une revue inserm-02380620v1
Improving the efficacy of hormone therapy in breast cancer: The role of cholesterol metabolism in SERM-mediated autophagy, cell differentiation and death Julie Leignadier,Florence Dalenc,Marc Poirot,Sandrine Silvente-Poirot Biochemical Pharmacology, 2017, 144, pp.18-28. ⟨10.1016/j.bcp.2017.06.120⟩ Article dans une revue inserm-02380608v1
Dendrogenin A drives LXR to trigger lethal autophagy in cancers Gregory Segala,Marion David,Philippe de Médina,Mathias Poirot,Nizar Serhanet al. Nature Communications, 2017, 8 (1), pp.1903. ⟨10.1038/s41467-017-01948-9⟩ Article dans une revue inserm-02380591v1
Improvement of 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, cholestane-3β,5α,6β-triol and 6-oxo-cholestan-3β,5α-diol recovery for quantification by GC/MS Régis Soules,Emmanuel Noguer,Luigi Iuliano,Chiara Zerbinati,Julie Leignadieret al. Chemistry and Physics of Lipids, 2017, 207, pp.92-98. ⟨10.1016/j.chemphyslip.2017.05.006⟩ Article dans une revue inserm-02380612v1
Quantitative analysis of the tumor suppressor dendrogenin A using liquid chromatography tandem mass spectrometry Emmanuel Noguer,Régis Soules,Claude Netter,Citra Nagarathinam,Julie Leignadieret al. Chemistry and Physics of Lipids, 2017, 207, pp.81-86. ⟨10.1016/j.chemphyslip.2017.06.010⟩ Article dans une revue inserm-02380602v1
Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor Maud Voisin,Philippe de Médina,Arnaud Mallinger,Florence Dalenc,Emilie Huc-Claustreet al. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (44), pp.E9346-E9355. ⟨10.1073/pnas.1707965114⟩ Article dans une revue hal-02316171v1
Molecular and Biochemical Analysis of the Estrogenic and Proliferative Properties of Vitamin E Compounds Farid Khallouki,Philippe de Médina,Stéphanie Caze-Subra,Kerstin Bystricky,Patrick Balagueret al. Frontiers in Oncology, 2016, 5, ⟨10.3389/fonc.2015.00287⟩ Article dans une revue hal-02271824v1
When cholesterol meets histamine, it gives rise to dendrogenin A: a tumour suppressor metabolite1 Marc Poirot,Sandrine Silvente-Poirot Biochemical Society Transactions, 2016, 44 (2), pp.631-637. ⟨10.1042/BST20150232⟩ Article dans une revue inserm-02380631v1
Dendrogenin A: A Mammalian Metabolite of Cholesterol with Tumor Suppressor and Neurostimulating Properties Florence Dalenc,Marc Poirot,Sandrine Silvente-Poirot Current Medicinal Chemistry, 2015, 22 (30), pp.3533-3549. ⟨10.2174/0929867322666150716114912⟩ Article dans une revue istex inserm-02380776v1
Cancer. Cholesterol and cancer, in the balance. Sandrine Silvente-Poirot,Marc Poirot Science, 2014, 343 (6178), pp.1445-1446. ⟨10.1126/science.1252787⟩ Article dans une revue inserm-00968924v1
Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies. Michel Record,Kevin Carayon,Marc Poirot,Sandrine Silvente-Poirot BBA - Biochimica et Biophysica Acta, 2014, 1841 (1), pp.108-120. ⟨10.1016/j.bbalip.2013.10.004⟩ Article dans une revue inserm-00968935v1
One step synthesis of 6-oxo-cholestan-3β,5α-diol. Maud Voisin,Sandrine Silvente-Poirot,Marc Poirot Biochemical and Biophysical Research Communications, 2014, 446 (3), pp.782-785. ⟨10.1016/j.bbrc.2014.01.138⟩ Article dans une revue inserm-00968933v1
The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells. Shaden A. M. Khalifa,Philippe de Médina,Anna Erlandsson,Hesham R. El-Seedi,Sandrine Silvente-Poirotet al. Biochemical and Biophysical Research Communications, 2014, 446 (3), pp.681-686. ⟨10.1016/j.bbrc.2013.12.134⟩ Article dans une revue inserm-00968932v1
Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism Brigitte Sola,Marc Poirot,Philippe de Médina,Sophie Bustany,Véronique Marsaudet al. Oncotarget, 2013, 4 (6), pp.911-922. ⟨10.18632/oncotarget.1066⟩ Article dans une revue inserm-00968940v1
5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of Tamoxifen in breast cancer cells. Gregory Segala,Philippe de Médina,Luigi Iuliano,Chiara Zerbinati,Michael R. Paillasseet al. Biochemical Pharmacology, 2013, 86 (1), pp.175-89. ⟨10.1016/j.bcp.2013.02.031⟩ Article dans une revue inserm-00822322v1
Technical note: Hapten synthesis, antibody production and development of an enzyme-linked immunosorbent assay for detection of the natural steroidal alkaloid Dendrogenin A. Philippe de Médina,Michael R. Paillasse,Gregory Segala,Talal Al Saati,Jeannine Boyeset al. Biochimie, 2013, 95 (3), pp.482-488. ⟨10.1016/j.biochi.2012.06.001⟩ Article dans une revue istex inserm-00822283v1
Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties. Philippe de Médina,Michael R. Paillasse,Gregory Segala,Maud Voisin,Loubna Mhamdiet al. Nature Communications, 2013, 4, pp.1840. ⟨10.1038/ncomms2835⟩ Article dans une revue inserm-00823974v1
Oxysterols and related sterols: Implications in pharmacology and pathophysiology. Marc Poirot,Sandrine Silvente-Poirot Biochemical Pharmacology, 2013, 86 (1), pp.1-2. ⟨10.1016/j.bcp.2013.05.001⟩ Article dans une revue istex inserm-00832422v1
Cholesterol-5,6-epoxides: Chemistry, biochemistry, metabolic fate and cancer. Marc Poirot,Sandrine Silvente-Poirot Biochimie, 2012, 95 (3), pp.622-631. ⟨10.1016/j.biochi.2012.05.006⟩ Article dans une revue istex inserm-00743461v1
Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles. Michael R. Paillasse,Nathalie Saffon,Heinz Gornitzka,Sandrine Silvente-Poirot,Marc Poirotet al. Journal of Lipid Research, 2012, 53 (4), pp.718-725. ⟨10.1194/jlr.M023689⟩ Article dans une revue inserm-00743457v1
Cholesterol metabolism and cancer: the good, the bad and the ugly. Sandrine Silvente-Poirot,Marc Poirot Current Opinion in Pharmacology, 2012, 12 (6), pp.673-6. ⟨10.1016/j.coph.2012.10.004⟩ Article dans une revue istex inserm-00822284v1
Cholesterol metabolism and resistance to tamoxifen. Marc Poirot,Sandrine Silvente-Poirot,Ralph R. Weichselbaum Current Opinion in Pharmacology, 2012, 12 (6), pp.683-689. ⟨10.1016/j.coph.2012.09.007⟩ Article dans une revue istex inserm-00743466v1
Cholesterol epoxide hydrolase and cancer. Sandrine Silvente-Poirot,Marc Poirot Current Opinion in Pharmacology, 2012, 12 (6), pp.696-703. ⟨10.1016/j.coph.2012.07.007⟩ Article dans une revue istex inserm-00743463v1
Exosomes as intercellular signalosomes and pharmacological effectors. Michel Record,Caroline Subra,Sandrine Silvente-Poirot,Marc Poirot Biochemical Pharmacology, 2011, 81 (10), pp.1171-1182. ⟨10.1016/j.bcp.2011.02.011⟩ Article dans une revue istex inserm-00743451v1
Importance of cholesterol and oxysterols metabolism in the pharmacology of tamoxifen and other AEBS ligands. Philippe de Médina,Michael R. Paillasse,Gregory Ségala,Farid Khallouki,Severine Brillouetet al. Chemistry and Physics of Lipids, 2011, 164 (6), pp.432-437. ⟨10.1016/j.chemphyslip.2011.05.005⟩ Article dans une revue istex inserm-00743454v1
Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins. Caroline Subra,David Grand,Karine Laulagnier,Alexandre Stella,Gerard Lambeauet al. Quarterly Reviews of Biophysics, 2010, 34 (3), epub ahead of print. ⟨10.1194/jlr.M003657⟩ Article dans une revue hal-00497229v1
Auraptene is an inhibitor of cholesterol esterification and a modulator of estrogen receptors. Philippe de Médina,Salvatore Genovese,Michael R. Paillasse,Mahta Mazaheri,Stéphanie Caze-Subraet al. Molecular Pharmacology, 2010, 78 (5), pp.827-36. ⟨10.1124/mol.110.065250⟩ Article dans une revue inserm-00519166v1
Synthesis, characterization and in vitro evaluation of new oxorhenium- and oxotechnetium-CCK4 derivatives as molecular imaging agents for CCK2-receptor targeting. Sandra Dorbes,Béatrice Mestre-Voegtlé,Yvon Coulais,Claude Picard,Sandrine Silvente-Poirotet al. European Journal of Medicinal Chemistry, 2010, 45 (2), pp.423-429. ⟨10.1016/j.ejmech.2009.09.043⟩ Article dans une revue istex inserm-00519153v1
Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands. Philippe de Médina,Michael R. Paillasse,Grégory Segala,Marc E. Poirot,Sandrine Silvente-Poirot Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (30), pp.13520-13525. ⟨10.1073/pnas.1002922107⟩ Article dans une revue inserm-00519159v1
Development of a new radioligand for cholecystokinin receptor subtype 2 scintigraphy: from molecular modeling to in vivo evaluation. Séverine Brillouet,Sandra Dorbes,Frédéric Courbon,Claude Picard,Jean Pierre Delordet al. Bioorganic and Medicinal Chemistry, 2010, 18 (14), pp.5400-5412. ⟨10.1016/j.bmc.2010.05.031⟩ Article dans une revue istex inserm-00519158v1
Ligands of the antiestrogen-binding site induce active cell death and autophagy in human breast cancer cells through the modulation of cholesterol metabolism. Philippe de Médina,Bruno Payré,Nadia Boubekeur,Justine Bertrand-Michel,François Tercéet al. Cell Death and Differentiation, 2009, 16 (10), pp.1372-1384. ⟨10.1038/cdd.2009.62⟩ Article dans une revue inserm-00519149v1
Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion. Michael R. Paillasse,Philippe de Médina,Guillaume Amouroux,Loubna Mhamdi,Marc E. Poirotet al. Journal of Lipid Research, 2009, 50 (11), pp.2203-2211. ⟨10.1194/jlr.M800668-JLR200⟩ Article dans une revue inserm-00519146v1
Synthesis of new alkylaminooxysterols with potent cell differentiating activities: identification of leads for the treatment of cancer and neurodegenerative diseases. Philippe de Médina,Michael R. Paillasse,Bruno Payré,Sandrine Silvente-Poirot,Marc E. Poirot Journal of Medicinal Chemistry, 2009, 52 (23), pp.7765-7777. ⟨10.1021/jm901063e⟩ Article dans une revue inserm-00519151v1
Tamoxifen and AEBS ligands induced apoptosis and autophagy in breast cancer cells through the stimulation of sterol accumulation. Philippe de Médina,Sandrine Silvente-Poirot,Marc E. Poirot Autophagy, 2009, 5 (7), pp.1066-1067. ⟨10.4161/auto.5.7.9820⟩ Article dans une revue inserm-00519150v1
Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism. Bruno Payré,Philippe de Médina,Nadia Boubekeur,Loubna Mhamdi,Justine Bertrand-Michelet al. Molecular Cancer Therapeutics, 2008, 7 (12), pp.3707-3718. ⟨10.1158/1535-7163.MCT-08-0507⟩ Article dans une revue inserm-00519145v1
Insights into the cholecystokinin 2 receptor binding site and processes of activation. Michaël Paillasse,Céline Deraeve,Philippe de Médina,Loubna Mhamdi,Gilles Favreet al. Molecular Pharmacology, 2006, 70 (6), pp.1935-1945. ⟨10.1124/mol.106.029967⟩ Article dans une revue inserm-00519168v1
The prototypical inhibitor of cholesterol esterification, Sah 58-035 [3-[decyldimethylsilyl]-n-[2-(4-methylphenyl)-1-phenylethyl]propanamide], is an agonist of estrogen receptors Philippe de Médina,Nadia Boubekeur,Patrick Balaguer,Gilles Favre,Sandrine Silvente-Poirotet al. Journal of Pharmacology and Experimental Therapeutics, 2006, 319 (1), pp.139-149. ⟨10.1124/jpet.106.104349⟩ Article dans une revue inserm-00090770v1
The peripheral cholecystokinin receptors Sandrine Silvente-Poirot,Marlène Dufresne,Nicole Vaysse,Daniel Fourmy European Journal of Biochemistry, 2005, 215 (3), pp.513-529. ⟨10.1111/j.1432-1033.1993.tb18061.x⟩ Article dans une revue inserm-04974721v1
Tamoxifen is a potent inhibitor of cholesterol esterification and prevents the formation of foam cells. Philippe de Médina,Bruno Payré,José Bernad,Isabelle Bosser,Bernard Pipyet al. Journal of Pharmacology and Experimental Therapeutics, 2004, 308 (3), pp.1165-1173. ⟨10.1124/jpet.103.060426⟩ Article dans une revue inserm-00090774v1
Molecular characterization of the microsomal tamoxifen binding site. Blandine Kedjouar,Philippe de Médina,Mustapha Oulad-Abdelghani,Bruno Payré,Sandrine Silvente-Poirotet al. Journal of Biological Chemistry, 2004, 279 (32), pp.34048-34061. ⟨10.1074/jbc.M405230200⟩ Article dans une revue inserm-00090773v1
Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis, and structure/affinity studies. Céline Galés,Marc E. Poirot,Julien Taillefer,Bernard Maigret,Jean Martinezet al. Molecular Pharmacology, 2003, 63, pp.973-982. ⟨10.1124/mol.63.5.973⟩ Article dans une revue inserm-00090776v1
High tumorigenic potential of a constitutively active mutant of the cholecystokinin 2 receptor. Céline Galés,Didier Sanchez,Marc E. Poirot,Stéphane Pyronnet,Louis Buscailet al. Oncogene, 2003, 22, pp.6081-6089. ⟨10.1038/sj.onc.1206823⟩ Article dans une revue inserm-00090775v1
The Biologically Crucial C Terminus of Cholecystokinin and the Non-peptide Agonist SR-146,131 Share a Common Binding Site in the Human CCK1 Receptor Chantal Escrieut,Véronique Gigoux,Elodie Archer,Sophie Verrier,Bernard Maigretet al. Journal of Biological Chemistry, 2002, 277 (9), pp.7546-7555. ⟨10.1074/jbc.M108563200⟩ Article dans une revue inserm-04974775v1
structure of cholecystokinin receptor binding sites and mechanism of activation/inactivation by agonists/antagonists Daniel Fourmy,Chantal Escrieu,Elodie Archer,Céline Galès,Véronique Gigouxet al. Pharmacology and Toxicology -Copenhagen-, 2002, 91, pp.313-320 Article dans une revue hal-00358676v1
The Third Intracellular Loop of the Rat and Mouse Cholecystokinin-A Receptors Is Responsible for Different Patterns of Gene Activation Roya Poosti,Laure Di Malta,Didier Gagne,Nicole Bernad,Jean-Claude Galleyrandet al. Molecular Pharmacology, 2000, 58 (6), pp.1381-1388. ⟨10.1124/mol.58.6.1381⟩ Article dans une revue inserm-04974769v1
Mutation of Asn-391 within the Conserved NPXXY Motif of the Cholecystokinin B Receptor Abolishes Gq Protein Activation without Affecting Its Association with the Receptor Céline Galés,Aline Kowalski-Chauvel,Marie Noelle Dufour,Catherine Seva,Luis Moroderet al. Journal of Biological Chemistry, 2000, 275 (23), pp.17321-17327. ⟨10.1074/jbc.M909801199⟩ Article dans une revue inserm-04974763v1
Arginine 336 and asparagine 333 of the human cholecystokinin-A receptor binding site interact with the penultimate aspartic acid and the C-terminal amide of cholecystokinin Véronique Gigoux,Chantal Escrieu,Jean-Alain Fehrentz,Sandrine Silvente-Poirot,Bernard Maigretet al. Journal of Biological Chemistry, 1999, 274 (29), pp.20457-20464. ⟨10.1074/jbc.274.29.20457⟩ Article dans une revue hal-00357552v1
Evidence for a Direct Interaction between the Penultimate Aspartic Acid of Cholecystokinin and Histidine 207, Located in the Second Extracellular Loop of the Cholecystokinin B Receptor Sandrine Silvente-Poirot,Chantal Escrieut,Céline Galès,Jean-Alain Fehrentz,Achim Escherichet al. Journal of Biological Chemistry, 1999, 274 (33), pp.23191-23197. ⟨10.1074/jbc.274.33.23191⟩ Article dans une revue inserm-04974753v1
evidence for a direct inetraction between the penultimate aspartic acid of cholecystokinin and histidine 207, located in the second extracellular loop of the cholecystokinin B receptor Sandrine Silvente-Poirot,Chantal Escrieu,Céline Galès,Jean-Alain Fehrentz,Achim Escherichet al. Journal of Biological Chemistry, 1999, 274 (33), pp.23191-23197 Article dans une revue hal-00357548v1
Arginine 197 of the cholecystokinin a receptor binding site interacts with the sulfate of the peptide agonist cholecystokinin Véronique Gigoux,Bernard Maigret,Chantal Escrieu,Sandrine Silvente-Poirot,Michelle Buissonet al. Protein Science, 1999, 8 (11), pp.2347-2354. ⟨10.1110/ps.8.11.2347⟩ Article dans une revue hal-00357556v1
Met-195 of the cholecystokinin-A receptor interacts with the sulfated tyrosine of cholecystokinin and is crucial for receptor transition to high affinity state Véronique Gigoux,Chantal Escrieu,Sandrine Silvente-Poirot,Bernard Maigret,Laurent Goullieuxet al. Journal of Biological Chemistry, 1998, 273 (23), pp.14380-14386. ⟨10.1074/jbc.273.23.14380⟩ Article dans une revue hal-00357491v1
Role of the Extracellular Domains of the Cholecystokinin Receptor in Agonist Binding Sandrine Silvente-Poirot,Chantal Escrieut,Stephen Wank Molecular Pharmacology, 1998, 54 (2), pp.364-371. ⟨10.1124/mol.54.2.364⟩ Article dans une revue inserm-04974746v1
Ligand-induced Internalization of Cholecystokinin Receptors Markus Pohl,Sandrine Silvente-Poirot,Joseph Pisegna,Nadya Tarasova,Stephen Wank Journal of Biological Chemistry, 1997, 272 (29), pp.18179-18184. ⟨10.1074/jbc.272.29.18179⟩ Article dans une revue inserm-04974735v1
A Segment of Five Amino Acids in the Second Extracellular Loop of the Cholecystokinin-B Receptor Is Essential for Selectivity of the Peptide Agonist Gastrin Sandrine Silvente-Poirot,Stephen Wank Journal of Biological Chemistry, 1996, 271 (25), pp.14698-14706. ⟨10.1074/jbc.271.25.14698⟩ Article dans une revue inserm-04974732v1
Electric properties of photoaffinity-labelled pancreatic A-subtype cholecystokinin J. Jiménez,M. Dufresne,Sandrine Silvente-Poirot,N. Vaysse,Daniel Fourmy Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 1990, 511, pp.333-9. ⟨10.1016/s0021-9673(01)93296-0⟩ Article dans une revue inserm-04974698v1

Brevet (88)

PHYTOSTEROL DERIVATIVES, AND COMPOSITIONS COMPRISING THE SAME, FOR USE AS MEDICAMENTS Sandrine Silvente-Poirot,Philippe de Medina,M Poirot France, Patent n° : EP2025064259. 2025 Brevet inserm-05110310v1
Methods for the treatment of cancers Sandrine Silvente-Poirot,Julio Buñay,Michel Record,Philippe de Medina,M Poirot France, Patent n° : EP25305623.8. 2025 Brevet inserm-05110314v1
Phytosterol derivatives, and compositions comprising the same, for use as medicaments Marc Poirot,Philippe de Medina,Sandrine Silvente-Poirot France, Patent n° : EP24305827. 2024 Brevet inserm-04773991v1
Methods for the treatment of breast cancer Marc Poirot,Philippe de Medina,Khadijetou Diallo,Sandrine Silvente-Poirot France, Patent n° : EP2430515.8.2024. 2024 Brevet inserm-04773966v1
Radiotraceurs de tomographie par émission de positrons (TEP) de fluoro-oxystérols Marc Poirot,Frédéric Courbon,Mohammad Samadi,Philippe de Medina,Sandrine Silvente-Poirotet al. France, N° de brevet: WO2024146880A1. 2024 Brevet inserm-04773942v1
METHODS AND PHARMACEUTICAL COMPOSITIONS FOR REPROGRAMING IMMUNE ENVIRONMENT IN A SUBJECT IN NEED THEREOF Marc Poirot,Julie Leignadier,Philippe de Medina,Michel Record,Sandrine Silvente-Poirot United States, Patent n° : US2023138400A1. 2023 Brevet inserm-04773900v1
Fluoro-oxysterols positron emission tomography (PET) radiotracers Marc Poirot,Frédéric Courbon,Mohammad Samadi,Philippe de Medina,Sandrine Silvente-Poirotet al. France, Patent n° : European patent, EP23305003.8. 2023 Brevet hal-04842549v1
PROCEDE POUR LA PREPARATION DE DERIVES DE STEROL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Canada, N° de brevet: CA2856609C. 2021 Brevet inserm-04772970v1
METHODS AND PHARMACEUTICAL COMPOSITIONS FOR REPROGRAMING IMMUNE ENVIRONMENT IN A SUBJECT IN NEED THEREOF Marc Poirot,Julie Leignadier,Philippe de Medina,Michel Record,Sandrine Silvente-Poirot United States, Patent n° : US2020016177A1. 2020 Brevet inserm-04773893v1
MÉTHODES ET COMPOSITIONS PHARMACEUTIQUES PERMETTANT LA REPROGRAMMATION DE L'ENVIRONNEMENT IMMUNITAIRE CHEZ UN SUJET EN AYANT BESOIN Marc Poirot,Julie Leignadier,Philippe de Medina,Michel Record,Sandrine Silvente-Poirot France, N° de brevet: EP3515453A1. 2019 Brevet inserm-04773879v1
Dendrogenina A y agentes antineoplásicos para el tratamiento de tumores quimiosensibles o quimiorresistentes Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot España, N° de brevet: ES2734425T3. 2019 Brevet inserm-04773729v1
Dendrogenin A and antineoplastic agents for the treatment of chemosensitive or chemoresistant tumors Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot France, Patent n° : US10188666B2. 2019 Brevet inserm-04773745v1
DENDROGÉNINE A ET AGENTS ANTINÉOPLASTIQUES POUR LE TRAITEMENT DES TUMEURS CHIMIOSENSITIVES OU CHIMIORÉSISTANTES Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot France, N° de brevet: EP3272350B1. 2019 Brevet inserm-04773717v1
Endrogenina A y agentes antineoplásicos para el tratamiento de tumores quimiosensibles o quimiorresistentes Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot España, N° de brevet: ES2656913T3. 2018 Brevet inserm-04773723v1
甾醇衍生物的制备方法 Marc Poirot,Michaël Paillasse,Philippe de Medina,Sandrine Silvente-Poirot China, Patent n° : CN104039807B. 2018 Brevet inserm-04773150v1
癌の診断法及びデンドロゲニンＡを用いての処置に対する癌の応答を予測する方法 Marc Poirot,Emmanuel Noguer,Sandrine Silvente-Poirot France, Patent n° : JP2018503064A. 2018 Brevet inserm-04773867v1
METHODS OF DIAGNOSING AND TREATING CANCER Marc Poirot,Sandrine Silvente-Poirot United States, Patent n° : US2018231556A1. 2018 Brevet inserm-04773847v1
MÉTHODES ET COMPOSITIONS PHARMACEUTIQUES PERMETTANT LA REPROGRAMMATION DE L'ENVIRONNEMENT IMMUNITAIRE CHEZ UN SUJET EN AYANT BESOIN Marc Poirot,Julie Leignadier,Philippe de Medina,Michel Record,Sandrine Silvente-Poirot France, N° de brevet: WO2018055080A1. 2018 Brevet inserm-04773906v1
DENDROGÉNINE A ET AGENTS ANTINÉOPLASTIQUES POUR LE TRAITEMENT DES TUMEURS CHIMIOSENSITIVES OU CHIMIORÉSISTANTES Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot France, N° de brevet: EP3272350A1. 2018 Brevet inserm-04773712v1
Sales de adición de ácidos de 5alfa-hidroxi-6beta-[2-(1H-imidazol-4-il)etilamino]colestan-3beta-ol Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Francia, N° de brevet: ES2650914T3. 2018 Brevet inserm-04772765v1
MÉTHODES DE DIAGNOSTIC DU CANCER ET DE PRÉDICTION DE RÉPONSE DU CANCER À UN TRAITEMENT À LA DENDROGÉNINE Marc Poirot,Emmanuel Noguer,Sandrine Silvente-Poirot France, N° de brevet: EP3221467A1. 2017 Brevet inserm-04773861v1
Proceso para la preparación de derivados de esterol Marc Poirot,Michaël Paillasse,Philippe de Medina,Sandrine Silvente-Poirot España, N° de brevet: ES2613753T3. 2017 Brevet inserm-04773222v1
DENDROGÉNINE A ET AGENTS ANTINÉOPLASTIQUES POUR LE TRAITEMENT DES TUMEURS CHIMIOSENSITIVES OU CHIMIORÉSISTANTES Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot France, N° de brevet: EP3041477B1. 2017 Brevet inserm-04773704v1
processo para o preparo de derivados de esterol Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Brazil, Patent n° : BR112014012458A2. 2017 Brevet inserm-04772921v1
Process for the preparation of sterol derivatives Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Austria, Patent n° : AU2012342460B2. 2017 Brevet inserm-04772907v1
ACID ADDITION SALTS OF 5a-HYDROXY-6ß-[2-(1H-IMIDAZOL-4-YL)ETHYL AMINO]CHOLESTAN-3ß-OL. Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Mexico, Patent n° : MX351610B. 2017 Brevet inserm-04772804v1
METHODS OF DIAGNOSING CANCER AND OF PREDICTING RESPONSE OF CANCER TO DENDROGENIN A TREATMENT Marc Poirot,Sandrine Silvente-Poirot,Emmanuel Noguer United States, Patent n° : US2017321283A1. 2017 Brevet inserm-04773868v1
METHODS OF DIAGNOSING AND TREATING CANCER Marc Poirot,Sandrine Silvente-Poirot United States, Patent n° : US2017234881A1. 2017 Brevet inserm-04773829v1
癌を診断及び処置する方法 Marc Poirot,Sandrine Silvente-Poirot Japan, Patent n° : JP2017527290A. 2017 Brevet inserm-04773842v1
ACID ADDITION SALTS OF 5ALPHA-HYDROXY-6BETA -[2-(1H-IMIDAZOL-4-YL)ETHYLAMINO]CHOLESTAN-3BETA -OL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : EP2768841B1. 2017 Brevet inserm-04772755v1
Methods for Determining the Oncogenic Condition of Cell, Uses Thereof, and Methods for Treating Cancer Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : US2017176446A1. 2017 Brevet inserm-04772284v1
MÉTHODES DE DIAGNOSTIC ET DE TRAITEMENT DU CANCER Marc Poirot,Sandrine Silvente-Poirot France, N° de brevet: EP3194615A1. 2017 Brevet inserm-04773835v1
ステロール誘導体の調製方法 Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : JP6157492B2. 2017 Brevet inserm-04773268v1
MÉTHODES DE DIAGNOSTIC DU CANCER ET DE PRÉDICTION DE RÉPONSE DU CANCER À UN TRAITEMENT À LA DENDROGÉNINE Marc Poirot,Sandrine Silvente-Poirot,Emmanuel Noguer France, N° de brevet: WO2016079057A1. 2016 Brevet inserm-04773871v1
Dendrogenin A and antineoplastic agents for the treatment of chemosensitive or chemoresistant tumors Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot China, Patent n° : CN105611934A. 2016 Brevet inserm-04773695v1
METHODES DE DIAGNOSTIC ET DE TRAITEMENT DU CANCER Marc Poirot,Sandrine Silvente-Poirot Canada, N° de brevet: CA2960036A1. 2016 Brevet inserm-04773830v1
METHODES DE DIAGNOSTIC DU CANCER ET DE PREDICTION DE REPONSE DU CANCER A UN TRAITEMENT A LA DENDROGENINE Marc Poirot,Emmanuel Noguer,Sandrine Silvente-Poirot Canada, N° de brevet: CA2968002A1. 2016 Brevet inserm-04773858v1
PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE STÉROL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, N° de brevet: EP2782923B1. 2016 Brevet inserm-04773181v1
PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Mexico, Patent n° : MX343787B. 2016 Brevet inserm-04773308v1
Process for the preparation of sterol derivatives Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina United States, Patent n° : US9447141B2. 2016 Brevet inserm-04773449v1
化学療法感受性又は化学療法抵抗性腫瘍の治療のためのデンドロゲニンＡ及び抗腫瘍薬 Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot Japan, Patent n° : JP2016532709A. 2016 Brevet inserm-04773739v1
DENDROGÉNINE A ET AGENTS ANTINÉOPLASTIQUES POUR LE TRAITEMENT DES TUMEURS CHIMIOSENSITIVES OU CHIMIORÉSISTANTES Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot France, N° de brevet: EP3041477A1. 2016 Brevet inserm-04773700v1
Dendrogenin A and antineoplastic agents for the treatment of chemosensitive or chemoresistant tumors Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot Australia, Patent n° : AU2014317117A1. 2016 Brevet inserm-04773484v1
MÉTHODES POUR DÉTERMINER L'ÉTAT ONCOGÉNIQUE D'UNE CELLULE, LEURS APPLICATIONS, ET MÉTHODES POUR TRAITER LE CANCER Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, N° de brevet: EP2446276B9. 2016 Brevet inserm-04772270v1
MÉTHODES DE DIAGNOSTIC ET DE TRAITEMENT DU CANCER Marc Poirot,Sandrine Silvente-Poirot France, N° de brevet: WO2016034742A1. 2016 Brevet inserm-04773852v1
DENDROGENIN A AND ANTINEOPLASTIC AGENTS FOR THE TREATMENT OF CHEMOSENSITIVE OR CHEMORESISTANT TUMORS Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot United States, Patent n° : US2016193233A1. 2016 Brevet inserm-04773751v1
METHODS FOR DETERMINING THE ONCOGENIC CONDITION OF CELL, USES THEREOF, AND METHODS FOR TREATING CANCER Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : PL2446276T3. 2015 Brevet inserm-04772282v1
СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ СТЕРИНА Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : RU2014125435A. 2015 Brevet inserm-04773440v1
DENDROGÉNINE A ET AGENTS ANTINÉOPLASIQUES POUR LE TRAITEMENT DE TUMEURS CHIMIOSENSIBLES OU CHIMIORÉSISTANTES Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot France, N° de brevet: WO2015032838A1. 2015 Brevet inserm-04773825v1
КИСЛОТНО-АДДИТИВНЫЕ СОЛИ 5α-ГИДРОКСИ-6β-[2-(1H-ИМИДАЗОЛ-4-ИЛ)ЭТИЛАМИНО]ХОЛЕСТАН-3β-ОЛА Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Russia, Patent n° : RU2014119929A. 2015 Brevet inserm-04772821v1
PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina India, Patent n° : IN976MUN2014A. 2015 Brevet inserm-04773233v1
DENDROGENINE A ET AGENTS ANTINEOPLASIQUES POUR LE TRAITEMENT DE TUMEURS CHIMIOSENSIBLES OU CHIMIORESISTANTES Marc Poirot,Philippe de Medina,Michaël Paillasse,Christian Récher,Sandrine Silvente-Poirot Canada, N° de brevet: CA2922715A1. 2015 Brevet inserm-04773546v1
ACID ADDITION SALTS OF 5ALFA-HYDROXY-6BETA-[2-(1H-IMIDAZOL-4-YL)ETHYL AMINO]CHOLESTAN-3BETA-OL. Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Mexico, Patent n° : MX2014004744A. 2015 Brevet inserm-04772791v1
ステロール誘導体の調製方法 Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Japan, Patent n° : JP2015502934A. 2015 Brevet inserm-04773250v1
PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina South Africa, Patent n° : ZA201403736B. 2015 Brevet inserm-04773467v1
細胞の腫瘍形成状態を決定する方法、その使用、及び癌の治療方法 Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : JP5765587B2. 2015 Brevet inserm-04772280v1
Aminoalkylsterol compounds with antitumoral and neuroprotective activity Marc Poirot,Sandrine Silvente-Poirot,Philippe de Medina France, Patent n° : US8957055B2. 2015 Brevet inserm-04772244v1
PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Mexico, Patent n° : MX2014006303A. 2014 Brevet inserm-04773301v1
ACID ADDITION SALTS OF 5α-HYDROXY-6β-[2-(1H-IMIDAZOL-4-YL)ETHYLAMINO]CHOLESTAN-3β-OL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina South Korea, Patent n° : KR20140083014A. 2014 Brevet inserm-04772786v1
PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES. Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Mexico, Patent n° : MX2014006303A. 2014 Brevet inserm-04773292v1
PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina United States, Patent n° : US2014309417A1. 2014 Brevet inserm-04773447v1
Acid addition salts of 5alpha-hydroxy-6beta-[2-(1H-imidazol-4-yl)ethylamino]cholestan-3beta-ol Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : AU2012324980A1. 2014 Brevet inserm-04772297v1
５α−ヒドロキシ−６β−［２−（１Ｈ−イミダゾール−４−イル）エチルアミノ］コレスタン−３β−オールの酸付加塩 Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Japan, Patent n° : JP2014530245A. 2014 Brevet inserm-04772775v1
PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina United States, Patent n° : US2014309417A1. 2014 Brevet inserm-04772885v1
Process for the preparation of sterol derivatives Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina China, Patent n° : CN104039807A. 2014 Brevet inserm-04773135v1
PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE STÉROL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, N° de brevet: EP2782923A1. 2014 Brevet inserm-04773167v1
ACID ADDITION SALTS OF 5ALPHA-HYDROXY-6BETA-[2-(1H-IMIDAZOL-4-YL)ETHYLAMINO]CHOLESTAN-3BETA-OL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina United States, Patent n° : US2014274984A1. 2014 Brevet inserm-04772841v1
Acid addition salts of 5[alpha]-hydroxy-6[beta]-[2-(1h-imidazol-4-yl)ethylamino]cholestan-3[beta]-ol Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : CN103958541A. 2014 Brevet inserm-04772748v1
Process for the preparation of sterol derivatives Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Austria, Patent n° : AU2012342460A1. 2014 Brevet inserm-04772895v1
Methods for determining the oncogenic condition of cell, uses thereof, and methods for treating cancer Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : CN102498404B. 2014 Brevet inserm-04772266v1
PROCESS FOR THE PREPARATION OF STEROL DERIVATES Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina South Korea, Patent n° : KR20140098131A. 2014 Brevet inserm-04773285v1
SELS D'ADDITION D'ACIDE DE 5Alpha-HYDROXY-6Beta-[2-(1H-IMIDAZOL-4-YL)- ÉTHYLAMINO]CHOLESTAN-3Beta-OL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, N° de brevet: WO2013057148A1. 2013 Brevet inserm-04772848v1
PROCEDE POUR LA PREPARATION DE DERIVES DE STEROL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina Canada, N° de brevet: CA2856609A1. 2013 Brevet inserm-04772952v1
PROCÉDÉ POUR LA PRÉPARATION DE DÉRIVÉS DE STÉROL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, N° de brevet: WO2013076257A1. 2013 Brevet inserm-04773460v1
SELS D'ADDITION D'ACIDE DE 5'-HYDROXY-6'-[2-(1H-IMIDAZOL-4-YL)- ETHYLAMINO]CHOLESTAN-3'-OL Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, N° de brevet: CA2852622A1. 2013 Brevet inserm-04772735v1
Aminoalkylsterol compounds with antitumoral and neuroprotective activity Marc Poirot,Sandrine Silvente-Poirot,Philippe de Medina France, Patent n° : US8524694B2. 2013 Brevet inserm-04772236v1
Aminoalkyl sterol compounds having an anti-tumoral and neuroprotective activity Marc Poirot,Sandrine Silvente-Poirot,Philippe de Medina France, Patent n° : US7947668B2. 2011 Brevet inserm-04772230v1
DETECTION DE L'ETAT ONCOGENE DE CELLULES HUMAINES OU DE MAMMIFERES PAR PRESENCE D'UN MARQUEUR ET EVALUATION DE L'ACTIVITE D'UN MEDICAMENT PAR DOSAGE DUDIT MARQUEUR Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : FR2947340B1. 2011 Brevet inserm-04772274v1
METHODES POUR DETERMINER L'ETAT ONCOGENIQUE D'UNE CELLULE, LEURS APPLICATIONS, ET METHODES POUR TRAITER LE CANCER Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, Patent n° : CA2766011A1. 2010 Brevet inserm-04772259v1
MÉTHODES POUR DÉTERMINER L'ÉTAT ONCOGÉNIQUE D'UNE CELLULE, LEURS APPLICATIONS, ET MÉTHODES POUR TRAITER LE CANCER Marc Poirot,Sandrine Silvente-Poirot,Michaël Paillasse,Philippe de Medina France, N° de brevet: WO2010149941A1. 2010 Brevet inserm-04772286v1
Aminoalkylsterol compounds having antitumor and neuroprotective activity Marc Poirot,Sandrine Silvente-Poirot,Philippe de Medina France, Patent n° : JP4601297B2. 2010 Brevet inserm-04772227v1
AMINOALKYL STEROL COMPOUNDS HAVING AN ANTI-TUMORAL AND NEUROPROTECTIVE ACTIVITY Marc Poirot,Sandrine Silvente-Poirot,Philippe de Medina France, Patent n° : EP1497309B1. 2009 Brevet inserm-04772209v1
AMINOALKYLSTERINVERBINDUNGEN MIT ANTI-KREBS UND NEUROPROTEKTIVER AKTIVITÄT Marc Poirot,Philippe de Medina,Sandrine Silvente-Poirot France, Patent n° : ATE420888T1. 2009 Brevet inserm-04772185v1
COMPUESTOS AMINOALQUILESTEROLES CON ACTIVIDAD ANTITUMORAL Y NEUROPROTECTORA Marc Poirot,Sandrine Silvente-Poirot,Philippe de Medina France, Patent n° : ES2321287T3. 2009 Brevet inserm-04772212v1
Aminoalkyl sterol compounds having an anti-tumoral and neuroprotective activity Philippe de Medina,Sandrine Silvente-Poirot,Marc Poirot France, Patent n° : AU2003262422B8. 2008 Brevet inserm-04772197v1
COMPOSES AMINOALKYLSTEROLES AVEC ACTIVITE ANTI-TUMEUR ET NEUROPROTECTRICE Marc Poirot,Philippe de Medina,Sandrine Silvente-Poirot France, Patent n° : EP1497309A2. 2005 Brevet inserm-04772177v1
STEROL DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND MEDICAMENTS COMPRISING SAME Marc Poirot,Philippe de Medina,Sandrine Silvente-Poirot France, Patent n° : WO03089449A2. 2003 Brevet inserm-04772249v1
AMINOALKYL STEROL COMPOUNDS HAVING AN ANTI-TUMORAL AND NEUROPROTECTIVE ACTIVITY Marc Poirot,Philippe de Medina,Sandrine Silvente-Poirot France, Patent n° : CA2481561A1. 2003 Brevet inserm-04772202v1

Pré-publication, Document de travail (2)

Oxysterols at the Crossroads of Cholesterol Metabolism and Cancer Marc Poirot,Silia Ayadi,Julio Buñay,Chloe Gressein,Philippe De Medinaet al. 2025 Pré-publication, Document de travail inserm-05345161v1
Liver X Receptors and the Hallmarks of Aging: From Molecular Mechanisms to Therapeutic Opportunities Marc Poirot,Julio Buñay,Silia Ayadi,Sandrine Silvente-Poirot,Philippe De Medina 2025 Pré-publication, Document de travail inserm-05329469v1

Chapitre d'ouvrage (2)

The Cholesterol-5,6-Epoxide Hydrolase: A Metabolic Checkpoint in Several Diseases Philippe de Medina,Silia Ayadi,Khadijetou Diallo,Julio Buñay,Laly Pucheuet al. Implication of Oxysterols and Phytosterols in Aging and Human Diseases, 1440, Springer International Publishing, pp.149-161, 2024, Advances in Experimental Medicine and Biology, ⟨10.1007/978-3-031-43883-7_8⟩ Chapitre d'ouvrage inserm-04317348v1
Vitamin E: an overview Farid Khallouki,Robert Wyn Owen,Mourad Akdad,Bachir El Bouhali,Sandrine Silvente-Poirotet al. Molecular Nutrition, Elsevier, pp.51-66, 2020, ⟨10.1016/B978-0-12-811907-5.00001-4⟩ Chapitre d'ouvrage inserm-03084874v1

Communication dans un congrès (24)

Cholesterol and cancer M Poirot,Sandrine Silvente-Poirot WebiNacre, réseau NaCRE, Jul 2024, Paris ( virtual ), France Communication dans un congrès inserm-05029268v1
Oxysterols M Poirot,Sandrine Silvente-Poirot Toulouse school of lipids, Inserm, Feb 2024, Toulouse, France Communication dans un congrès inserm-05029054v1
Chemical synthesis and biochemical properties of cholestane-5α,6β-diol-3-sulfonate, a non-hydrolysable analogue of cholestane-5α,6β-diol-3β-sulfate Philippe de Medina,Silia Ayadi,Regis Soules,Bruno Payre,Sandrine Rup-Jacqueset al. 12th ENOR symposium : Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France Communication dans un congrès inserm-05029639v1
Biochemical and structural evidences that the human glutathion S-transferase A1 catalyzes the biosynthesis of dendrogenins. Silia Ayadi,Georges Ndikoum-Matip,Philippe de Medina,Regis Soules,Virginie Nahoumet al. 12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France Communication dans un congrès inserm-05029665v1
Metabolic switching from tumor promoter activities of oncosterone and 27-hydroxycholesterol to 27-hydroxy-oncosterone with antiproliferative properties Silia Ayadi,Silvia Friedrichs,Regis Soulès,Laly Pucheu,Dieter Lütjohannet al. 12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France Communication dans un congrès inserm-05029635v1
The oxysterol dendrogenin A increases the activation of migratory dendritic cells by acting through the LXRβ. Julio Buñay,Laly Pucheu,Silia Ayadi,Michel Record,Philippe de Medinaet al. 12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France Communication dans un congrès inserm-05029673v1
Synthesis and cellular evaluation of new bi-specific estrogen receptor modulators and ACAT/SOAT inhibitors as anticancer agents Farid Khallouki,M Poirot,Stéphanie Caze-Subra,Kerstin Bystricky,Sandrine Silvente-Poirotet al. 12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France Communication dans un congrès inserm-05029726v1
Discovery of a new metabolic branch on the cholesterol pathway: importance in cancers and other diseases M Poirot,Sandrine Silvente-Poirot Smith-Lemli-Opitz Conferences, SLO foundation, Jun 2023, Seattle, United States Communication dans un congrès inserm-05029087v1
The 5,6-epoxycholesterol metabolic branch: possible involvement in aging and degenerative diseases M Poirot,Sandrine Silvente-Poirot invited conference, Bruce D Hammock, Jan 2023, Davis (virtual conference), United States Communication dans un congrès inserm-05029116v1
Combined OCDO/DDA extraction and quantification method for a fast and accurate HPLC-MS analysis Regis Soules,Philippe de Medina,Silia Ayadi,Étienne Chatelut,Sandrine Silvente-Poirotet al. 12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France Communication dans un congrès inserm-05029741v1
GSTA1-1 is a multifunctional enzyme involved in 5,6α-epoxycholesterol conjugation with biological nucleophiles Silia Ayadi,Georges Ndikoum-Matip,Philippe de Medina,Virginie Nahoum,Laurent Maveyraudet al. 11th ENOR symposium, ENOR, Sep 2022, Oslo, Norway Communication dans un congrès inserm-05029750v1
A combined OCDO/DDA extraction and quantification method for a fast and accurate determination of a carcinogenic metabolic deregulation in patients Regis Soules,Étienne Chatelut,Sandrine Silvente-Poirot,M Poirot,Ben Allal 11th ENOR symposium, ENOR, Sep 2022, Oslo, Norway Communication dans un congrès inserm-05029775v1
Reprogramming tumor cells with the oxysterol, dendrogenin A, to release immunogenic anti-tumor small extracellular vesicles enriched in exosomes. Julio Buñay,Michel Record,Laly Pucheu,M Poirot,Philippe de Medinaet al. 11th ENOR symposium, ENOR, Sep 2022, Oslo, Norway Communication dans un congrès inserm-05029772v1
Chemical synthesis and biological properties of cholestane-5α,6β-diol-3-sulfonate, a non-hydrolyzable analogue of cholestane-5α,6β-diol-3-O-sulfate Philippe de Medina,Mohammad Samadi,Silia Ayadi,Sandrine Rup-Jacques,Regis Souleset al. 11th ENOR symposium (European Network for Oxysterol Research), ENOR, Sep 2022, Oslo, Norway Communication dans un congrès inserm-05029757v1
Comparative Studies on the metabolism of 5,6-epoxycholesterol, cholestane-3β,5α,6β-triol and Oncosterone in the cancer cell lines MCF-7, MDA-MB-231 and HEPG2. Philippe de Medina,Silia Ayadi,Dieter Lütjohann,Sandrine Silvente-Poirot,M Poirot 11th ENOR symposium, ENOR, Sep 2022, Oslo, Norway Communication dans un congrès inserm-05029763v1
New targeting in oxysterol metabolism for triple negative breast cancer therapy. Khadijetou Diallo,Philippe de Medina,Regis Soules,Laly Pucheu,Arnaud Mallingeret al. 10th ENOR Symposium – Web Meeting, ENOR, Sep 2021, Web Conf, United Kingdom Communication dans un congrès inserm-05029825v1
Side chain hydroxylation of cholestane-3β,5α,6β-triol and Oncosterone lead to the production of new endogenous oxysterols potentially involved in breast cancer development. Tifany Lalande,Regis Soules,Sandrine Silvente-Poirot,Philippe de Medina,M Poirot 10th ENOR Symposium – Web Meeting, ENOR, Sep 2021, Web Conf, United Kingdom Communication dans un congrès inserm-05029836v1
Characterization of a cholesterol metabolic switch controlling breast carcinogenesis M Poirot,Sandrine Silvente-Poirot 10th ENOR annual symposium, ENOR, Sep 2021, Oslo / Virtual, Norway Communication dans un congrès inserm-05029135v1
Inhibition of oncosterone biosynthesis as a new pharmacological anticancer strategy in breast cancer. Philippe de Medina,Rabea Bartölke,Regis Soules,Sandrine Silvente-Poirot,M Poirot 10th ENOR Symposium – Web Meeting, ENOR, Sep 2021, Web Conf, United Kingdom Communication dans un congrès inserm-05029843v1
Characterization of a cholesterol metabolic switch controlling breast carcinogenesis Philippe de Medina,Silia Ayadi,Emmanuel Noguer,Lisa Barrett,Regis Souleset al. 10th ENOR Symposium – Web Meeting, ENOR, Sep 2021, Web Conf, United Kingdom Communication dans un congrès inserm-05029820v1
Biochemical and pharmacological characterization of the enzyme responsible for the biosynthesis of 6-oxo-cholestan-3β-5α-diol (OCDO), a carcinogenic oxysterol M Poirot,Sandrine Silvente-Poirot 9th ENOR SYMPOSIUM, Metabolism and Oxysterols: Therapeutics for Lifelong Health, ENOR, Sep 2019, Edinbourg, Ecosse, United Kingdom Communication dans un congrès inserm-05029857v1
Biochemical and pharmacological characterization of the enzyme responsible for the biosynthesis of 6-oxo-cholestan-3β-5α-diol (OCDO), a carcinogenic oxysterol M Poirot,Sandrine Silvente-Poirot 9th ENOR SYMPOSIUM, Metabolism and Oxysterols: Therapeutics for Lifelong Health, ENOR, Sep 2019, Edimburgh, Scotland, United Kingdom Communication dans un congrès inserm-05029141v1
Design, synthesis and cellular evaluation of new bi-specific estrogen receptor modulators and ACAT inhibitors as anticancer agents Farid Khallouki,Guillaume Amouroux,Stéphanie Caze-Subra,Kerstin Bystricky,Patrick Balagueret al. 9th ENOR SYMPOSIUM, Metabolism and Oxysterols: Therapeutics for Lifelong Health, ENOR, Sep 2019, Edinbourg, Ecosse, United Kingdom Communication dans un congrès inserm-05029855v1
An oxysterol oncometabolite and glucocorticoid receptor signaling in triple negative breast cancer cell proliferation. Arnaud Mallinger,Khadijetou Diallo,M Poirot,Sandrine Silvente-Poirot 9th ENOR SYMPOSIUM, Metabolism and Oxysterols: Therapeutics for Lifelong Health, ENOR, Sep 2019, Edinbourgh (Scotland), United Kingdom Communication dans un congrès inserm-05029849v1

Article de blog scientifique (1)

Cholesterol et cancer Marc Poirot,Sandrine Silvente-Poirot 2024 Article de blog scientifique inserm-04774192v1