Sandrine Vadon - Le Goff

Publications

Article dans une revue (36)

A noncanonical‐ GPRC5A signaling regulates keratinocyte adhesion and migration by nuclear translocation Sarah Chanteloube,Choua Ya,Gabrielle Le Provost,Aurore Berthier,Cindy Dieryckxet al. FASEB Journal, 2025, 39 (2), pp.e70323. ⟨10.1096/fj.202400122R⟩ Article dans une revue hal-04933989v1
PCPE-2 (procollagen C-proteinase enhancer-2): The non-identical twin of PCPE-1 Manon Napoli,Julien Bauer,Christelle Bonod,Sandrine Vadon-Le Goff,Catherine Moali Matrix Biology, 2024, 134, pp.59-78. ⟨10.1016/j.matbio.2024.09.001⟩ Article dans une revue hal-04727512v1
Mono- and Bi-specific Nanobodies Targeting the CUB Domains of PCPE-1 Reduce the Proteolytic Processing of Fibrillar Procollagens Priscillia Lagoutte,Jean-Marie Bourhis,Natacha Mariano,Virginie Gueguen-Chaignon,David Vandrouxet al. Journal of Molecular Biology, 2024, 436 (16), pp.168667. ⟨10.1016/j.jmb.2024.168667⟩ Article dans une revue hal-04727482v1
Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system Marine Blanc,Clara Lettl,Jérémy Guérin,Anaïs Vieille,Sven Furleret al. PLoS Pathogens, 2023, 19 (5), pp.e1011368. ⟨10.1371/journal.ppat.1011368⟩ Article dans une revue hal-04246055v1
Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases Sandrine Vadon-Le Goff,Agnès Tessier,Manon Napoli,Cindy Dieryckx,Julien Baueret al. Nature Communications, 2023, 14, pp.8020. ⟨10.1038/s41467-023-43401-0⟩ Article dans une revue hal-04350568v1
Dynamics of the secreted frizzled related protein Sizzled and potential implications for binding to bone morphogenetic protein-1 (BMP-1) Urvashi Sharma,Sandrine Vadon-Le Goff,Karl Harlos,Yuguang Zhao,Natacha Marianoet al. Scientific Reports, 2022, 12 (1), pp.14850. ⟨10.1038/s41598-022-18795-4⟩ Article dans une revue hal-03838405v1
Procollagen C-proteinase enhancer-1 (PCPE-1), a potential biomarker and therapeutic target for fibrosis Priscillia Lagoutte,Emmanuel Bettler,Sandrine Vadon-Le Goff,Catherine Moali Matrix Biology Plus, 2021, 11, pp.100062. ⟨10.1016/j.mbplus.2021.100062⟩ Article dans une revue hal-03368863v1
BMP-1 disrupts cell adhesion and enhances TGF-β activation through cleavage of the matricellular protein thrombospondin-1 Cyril Anastasi,Patricia Rousselle,Maya Talantikite,Agnès Tessier,Caroline Cluzelet al. Science Signaling, 2020, 13 (639), pp.eaba3880. ⟨10.1126/scisignal.aba3880⟩ Article dans une revue hal-02991455v1
Structural Basis for the Acceleration of Procollagen Processing by Procollagen C-Proteinase Enhancer-1 David Pulido,Urvashi Sharma,Sandrine Vadon-Le Goff,Sadaf-Ahmahni Hussain,Sarah Cordeset al. Structure, 2018, 26 (10), pp.1384-1392.e3. ⟨10.1016/j.str.2018.06.011⟩ Article dans une revue hal-03094449v1
Structural Basis for the Acceleration of Procollagen Processing by Procollagen C-Proteinase Enhancer-1 David Pulido,Urvashi Sharma,Sandrine Vadon-Le Goff,Sadaf-Ahmahni Hussain,Sarah Cordeset al. Structure, 2018, 26 (10), pp.1384-1392.e3. ⟨10.1016/j.str.2018.06.011⟩ Article dans une revue hal-02342439v1
Inhibitors of BMP-1/tolloid-like proteinases: efficacy, selectivity and cellular toxicity Maya Talantikite,Pascaline Lecorché,Fabrice Beau,Odile Damour,Christoph Becker-Paulyet al. FEBS Open Bio, 2018, 8 (12), pp.2011-2021. ⟨10.1002/2211-5463.12540⟩ Article dans une revue hal-02342437v1
Deficiency of the DSPP-cleaving enzymes meprin α and meprin β does not result in dentin malformation in mice Philipp Arnold,Lara Koopmann,Florian Peters,Falk Birkenfeld,Sandrine Vadon-Le Goffet al. Cell and Tissue Research, 2017, 367 (2), pp.351-358. ⟨10.1007/s00441-016-2498-3⟩ Article dans une revue hal-02342448v1
Structural basis of homo- and heterotrimerization of collagen I Urvashi Sharma,Loïc Carrique,Sandrine Vadon-Le Goff,Natacha Mariano,Rainier-Numa Georgeset al. Nature Communications, 2017, 8 (1), ⟨10.1038/ncomms14671⟩ Article dans une revue hal-02342446v1
Interaction of Complement Defence Collagens C1q and Mannose-Binding Lectin with BMP-1/Tolloid-like Proteinases Monique Lacroix,Agnès Tessier,Chantal Dumestre-Pérard,Sandrine Vadon-Le Goff,Evelyne Goutet al. Scientific Reports, 2017, 7, pp.16958. ⟨10.1038/s41598-017-17318-w⟩ Article dans une revue hal-01657764v1
Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-β signaling as primary targets Mourad Bekhouche,Cedric Leduc,Laura Dupont,Lauriane Janssen,Frédéric Delolmeet al. FASEB Journal, 2016, 30 (5), pp.1741-1756. ⟨10.1096/fj.15-279869⟩ Article dans une revue hal-02342452v1
Proteolytic control of TGF-β co-receptor activity by BMP-1/tolloid-like proteases revealed by quantitative iTRAQ proteomics Frédéric Delolme,Cyril Anastasi,Lindsay B Alcaraz,Valentin Mendoza,Sandrine Vadon-Le Goffet al. Cellular and Molecular Life Sciences, 2015, 72 (5), pp.1009-1027. ⟨10.1007/s00018-014-1733-x⟩ Article dans une revue hal-02283031v1
BMP-1/tolloid-like proteinases synchronize matrix assembly with growth factor activation to promote morphogenesis and tissue remodeling Sandrine Vadon-Le Goff,David J.S. Hulmes,Catherine Moali Matrix Biology, 2015, 44-46, pp.14-23. ⟨10.1016/j.matbio.2015.02.006⟩ Article dans une revue hal-02342455v1
Proteolytic control of TGF-β co-receptor activity by BMP-1/tolloid-like proteases revealed by quantitative iTRAQ proteomics Frédéric Delolme,Cyril Anastasi,Lindsay Alcaraz,Valentin Mendoza,Sandrine Vadon-Le Goffet al. Cellular and Molecular Life Sciences, 2014, 72 (5), pp.1009-1027. ⟨10.1007/s00018-014-1733-x⟩ Article dans une revue hal-04766559v1
Procollagen C-proteinase enhancer grasps the stalk of the C-propeptide trimer to boost collagen precursor maturation. Jean-Marie Bourhis,Sandrine Vadon-Le Goff,Hassnae Afrache,Natacha Mariano,Daniel Kronenberget al. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (16), pp.6394-9 Article dans une revue hal-01322415v1
IMPROVED AND HIGH YIELD SYNTHESIS OF THE POTENT ARGINASE INHIBITOR : 2(S)-AMINO-6-BORONOHEXANOIC ACID Sandrine Vadon-Le Goff,Sylvie Dijols,Daniel Mansuy,Jean-Luc Boucher Organic Process Research and Development, 2005, 9, pp.677-679 Article dans une revue hal-00097853v1
SYNTHESIS AND EVALUATION OF NEW OMEGA-BORONO-ALPHA-AMINOACIDS AS RAT LIVER ARGINASE INHIBITORS Olivier Busnel,François Carreaux,Bertrand Carboni,Stéphanie Pethe,Sandrine Vadon-Le Goffet al. Bioorganic and Medicinal Chemistry, 2005, 13, pp.2373-2379 Article dans une revue hal-00097475v1
Coordination chemistry of the heme in cystathionine beta-synthase: formation of iron(II)-isonitrile complexes. S. Vadon-Legoff,M. Delaforge,Jl Boucher,M. Janosik,Jp Krauset al. Biochemical and Biophysical Research Communications, 2001, 283, pp.487-492 Article dans une revue hal-00315217v1
Modulation of cholinergic airway reactivity and nitric oxide production by endogenous arginase activity. H. Meurs,Ma Hamer,S. Pethe,S. Vadon-Legoff,Jl Boucheret al. British Journal of Pharmacology, 2000, 130, pp.1793-1798 Article dans une revue hal-00315218v1
Biosynthèse du monoxyde d'azote (NO) : mécanisme, régulation et contrôle Nicolas Sennequier,Sandrine Vadon-Le Goff Médecine/Sciences, 1998, 14 (11), pp.1185-1195 Article dans une revue hal-00127937v1
Inhibition of arginase in rat alveolar macrophages (AM phi) promotes utilization of L-arginine by nitric oxide synthase (NOS). C. Hey,Jl Boucher,S. Vadon,G. Ketterer,C. Stichnoteet al. Naunyn-Schmiedeberg's Archives of Pharmacology, 1997, 355, pp.138-138 Article dans une revue hal-00315242v1
Inhibition of arginase in rat and rabbit alveolar macrophages by N omega-hydroxy-D,L-indospicine, effects on L-arginine utilization by nitric oxide synthase. C. Hey,Jl Boucher,S. Vadon-Legoff,G. Ketterer,I. Wessleret al. British Journal of Pharmacology, 1997, 121, pp.395-400 Article dans une revue hal-00315220v1
N-omega-OH-D,L-indospicine, a potent and selective: Inhibitor of arginase in rat and rabbit alveolar macrophages (AM phi) can promote utilization of L-arginine by nitric oxide synthase (NOS) C. Hey,Jl Boucher,S. Vadon,G. Ketterer,C. Stichnoteet al. British Journal of Pharmacology, 1997, 120, pp.P48-P48 Article dans une revue hal-00315247v1
Synthesis and effects on arginase and nitric oxide synthase of two novel analogues of N omega-hydroxyarginine, N omega-hydroxyindospicine and p-hydroxyamidinophenylalanine S. Vadon,J. Custot,Jl Boucher,Xxxx Mansuyd JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1996, xxx, pp.645-648 Article dans une revue hal-00315239v1
Expression in yeast and purification of functional macrophage nitric oxide synthase. Evidence for cysteine-194 as iron proximal ligand. Ma Sari,S. Booker,M. Jaouen,S. Vadon,Ji Boucheret al. Biochemistry, 1996, 35, pp.7204-7213 Article dans une revue hal-00315221v1
Oxidation of arylamidoximes by hydrogen peroxide and horseradish peroxidase in water: Easy preparation and X-ray structure of O-(arylimidoyl)arylamidoximes. Jl Boucher,S. Vadon,A. P. Tomas,B. Viossat,Xxxx Mansuyd Tetrahedron Letters, 1996, 37, pp.3113-3116 Article dans une revue hal-00315240v1
N omega-hydroxyamino-alpha-amino acids as a new class of very strong inhibitors of arginases J. Custot,Jl Boucher,S. Vadon,C. Guedes,S. Dijolset al. Journal of Biological Inorganic Chemistry, 1996, 1, pp.73-82 Article dans une revue hal-00315238v1
N-OMEGA-HYDROXY-L-ARGININE, AN INTERMEDIATE IN THE L-ARGININE TO NITRIC-OXIDE PATHWAY, IS A STRONG INHIBITOR OF LIVER AND MACROPHAGE ARGINASE Jl Boucher,J. Custot,S. Vadon,M. Delaforge,M. Lepoivreet al. Biochemical and Biophysical Research Communications, 1994, 203, pp.1614-1621 Article dans une revue hal-00315241v1
N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase. Jl Boucher,J. Custot,S. Vadon,M. Delaforge,M. Lepoivreet al. Biochemical and Biophysical Research Communications, 1994, 203, pp.1614-1621 Article dans une revue hal-00315248v1
Particular ability of liver P450s3A to catalyze the oxidation of N omega-hydroxyarginine to citrulline and nitrogen oxides and occurrence in no synthases of a sequence very similar to the heme-binding sequence in P450s. Jp Renaud,Jl Boucher,S. Vadon,M. Delaforge,D. Mansuy Biochemical and Biophysical Research Communications, 1993, 192, pp.53-60 Article dans une revue hal-00315222v1
Cytochrome P450 catalyzes the oxidation of N omega-hydroxy-L-arginine by NADPH and O2 to nitric oxide and citrulline. Jl Boucher,A. Genet,S. Vadon,M. Delaforge,Y. Henryet al. Biochemical and Biophysical Research Communications, 1992, 187, pp.880-886 Article dans une revue hal-00315223v1
Formation of nitrogen oxides and citrulline upon oxidation of N omega-hydroxy-L-arginine by hemeproteins. Jl Boucher,A. Genet,S. Vadon,M. Delaforge,D. Mansuy Biochemical and Biophysical Research Communications, 1992, 184, pp.1158-1164 Article dans une revue hal-00315224v1

Communication dans un congrès (5)

Structural and biochemical analysis of Mini-Procollagen I C-terminal maturation Oskar Lipinski,Cindy Dieryckx,Natacha Mariano,Loic Carrique,Sandrine Vadon-Le Goffet al. Fourth Annual Meeting of the ProteoCure COST Action, May 2025, Heraklion (Grèce), Greece Communication dans un congrès hal-05400016v1
Recombinant mini-procollagens as tools for the biochemical characterization of collagen maturation Oskar Lipinski,Cindy Dieryckx,Natacha Mariano,Agnès Tessier,Jean-Baptiste Vincourtet al. Congrès annuel de la Société Française de Biochimie et Biologie Moléculaire, Jul 2024, Lyon, France Communication dans un congrès hal-05396745v1
The dark side of procollagen C-proteinase enhancer-2 (PCPE-2): inhibition of bone morphogenetic protein-1/tolloid-like proteinases Sandrine Vadon-Le Goff,Agnès Tessier,Manon Napoli,Mélissa Dussoyer,Priscillia Lagoutteet al. ANNUAL MEETING OF THE FRENCH SOCIETY FOR EXTRACELLULAR MATRIX BIOLOGY, Nov 2023, Strasbourg (FRANCE), France Communication dans un congrès hal-05400034v1
Nanobodies directed against procollagen C-proteinase enhancer 1 efficiently slow down the proteolytic maturation of fibrillar procollagens Priscillia Lagoutte,Jean-Marie Bourhis,Virginie Gueguen-Chaignon,Natacha Mariano,David Vandrouxet al. ECM Pharmacology Congress 2022, Jun 2022, Copenaghen, Denmark Communication dans un congrès hal-05396731v1
Strong alterations of collagen biosynthesis and fibrillogenesis in the dermis of recessive dystrophic epidermolysis bullosa mice Mélissa Dussoyer,Adeline Page,Frédéric Delolme,Dimitra Kiritsi,Sandrine Vadon-Le Goffet al. WOUND REPAIR AND REGENERATION - European Tissue Repair Society Meeting-2022, European Tissue Repair Society, Sep 2022, Lyon, France. pp.A30-A31 Communication dans un congrès hal-04911707v1

Poster de conférence (10)

Insight into Procollagen I C-terminal maturation through structural and biochemical studies Oskar Lipinski,Cindy Dieryckx,Natacha Mariano,Loic Carrique,Sandrine Vadon-Le Goffet al. Congrès 2025 de la Société Française de Biologie de la Matrice Extracellulaire, Sep 2025, Toulouse, France Poster de conférence hal-05397907v1
Development of an anti-fibrotic drug candidate targeting the PCPE regulators of BMP-1/tolloid like proteases Sandrine Vadon-Le Goff,Priscillia Lagoutte,Laura Chastagnier,Julien Bauer,Olivier Bouchotet al. 13th general Meeting of the International Proteolysis Society, Oct 2025, Buzios (Brazil), Brazil Poster de conférence hal-05397879v1
Structural and Biochemical Analysis of Mini-Procollagen I C-Terminal Maturation Oskar Lipinski,Cindy Dieryckx,Natacha Mariano,Loic Carrique,Sandrine Vadon-Le Goffet al. 4th MOSBRI (MOlecular-Scale Biophysics Research Infrastructure) Scientific Conference, Jun 2025, Paris, France Poster de conférence hal-05397918v1
Insights into the mechanism of action of PCPE-2, the endogenous inhibitor of human BMP-1/tolloid-like proteinases Julien Bauer,Priscillia Lagoutte,Jonathan Vaneyck,Loic Carrique,Mireille Dumoulinet al. Matrix Biology Europe 2024, Sep 2024, Lyon, France Poster de conférence hal-05400090v1
Investigating collagen maturation biochemistry through recombinant mini procollagens Oskar Lipinski,Cindy Dieryckx,Natacha Mariano,Jean-Baptiste Vincourt,Loic Carriqueet al. Matrix Biology Europe 2024, Sep 2024, Lyon, France Poster de conférence hal-05400117v1
Insights into the mechanism of action of PCPE-2, the endogenous inhibitor of human BMP-1/tolloid-like proteinases Julien Bauer,Jonathan Vaneyck,Mireille Dumoulin,Catherine Moali,Sandrine Vadon-Le Goff Congrès annuel de la Société Française de Biochimie et Biologie Moléculaire, Jul 2024, Lyon, France Poster de conférence hal-05400147v1
The dark side of procollagen C-proteinase enhancer-2 (PCPE-2): inhibition of bone morphogenetic protein-1/tolloid-like proteinases Sandrine Vadon-Le Goff,Agnès Tessier,Manon Napoli,Mélissa Dussoyer,Priscillia Lagoutteet al. ECM Pharmacology Congress 2024, Jun 2024, Copenhagen, Denmark Poster de conférence hal-05396726v1
The dark side of procollagen C-proteinase enhancer-2 (PCPE-2): inhibition of bone morphogenetic protein-1/tolloid-like proteinases Sandrine Vadon-Le Goff,Agnès Tessier,Manon Napoli,Mélissa Dussoyer,Priscillia Lagoutteet al. Gordon Research Conference Collagen 2023, Jul 2023, New London (New Hampshire), United States Poster de conférence hal-05396719v1
Nanobodies directed against procollagen C-proteinase enhancer 1 efficiently slow down the proteolytic maturation of fibrillar procollagens Priscillia Lagoutte,Jean-Marie Bourhis,Virginie Gueguen-Chaignon,Natacha Mariano,David Vandrouxet al. Joint Meeting on Proteostasis and Cellular Proteolysis, May 2023, Paris, France Poster de conférence hal-05396690v1
Nanobodies directed against procollagen C-proteinase enhancer 1 efficiently slow down the proteolytic maturation of fibrillar procollagens Priscillia Lagoutte,Jean-Marie Bourhis,Virginie Gueguen-Chaignon,Natacha Mariano,David Vandrouxet al. Matrix Biology Europe, Sep 2022, Firenze, Italy, Italy Poster de conférence hal-05396676v1

Brevet (2)

PROTEIN AND FRAGMENTS THEREOF, AND THEIR USE Sandrine Vadon-Le Goff,Catherine Moali France, Patent n° : EP 4 484 444 A1. 2025 Brevet hal-05400194v1
Ligand specific for the PCPE-1 glycoprotein and uses thereof Sandrine Vadon-Le Goff,Catherine Moali,Priscillia Lagoutte,David Vandroux,Alexandra Oudot France, Patent n° : WO2023/175277 A1. 2023 Brevet hal-05400224v1

Pré-publication, Document de travail (4)

GPRC5A regulates keratinocyte adhesion and migration through nuclear translocation of its C-terminus region Sarah Chanteloube,Choua Ya,Gabrielle Le Provost,Aurore Berthier,Cindy Dieryckxet al. 2024 Pré-publication, Document de travail hal-04769753v1
Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system Marine Blanc,Clara Lettl,Jérémy Guérin,Anaïs Vieille,Sven Furleret al. 2022 Pré-publication, Document de travail hal-03850702v1
Production of recombinant heterotrimeric mini-procollagen I and homotrimeric mini-procollagen II reveals new cleavage sites for BMP-1 Natacha Mariano,Cindy Dieryckx,Agnès Tessier,Jean-Baptiste Vincourt,Sandrine Vadon-Le Goffet al. 2022 Pré-publication, Document de travail hal-03851708v1
Procollagen C-Proteinase Enhancer 1 (PCPE-1) is a marker of myocardial fibrosis and impaired cardiac function in a murine model of pressure overload Priscillia Lagoutte,Alexandra Oudot,Mélissa Dussoyer,Victor Goncalves,Mélanie Guilleminet al. 2021 Pré-publication, Document de travail hal-03372769v1