Sébastien Comesse

Présentation

Sébastien Comesse was born in 1973 and he obtained in 2001 his Ph.D. degree from Sorbonne University (Pierre et Marie Curie University) under the supervision of C Kadouri. He became Assistant Professor in 2005 in the URCOM (Unité de Recherche en Chimie Organique et Macromoléculaire) Laboratory of the University of Le Havre Normandie.

1. L'axe de recherche (avec un choix de deux axes).

Axe 1. Chimie durable et Santé

2. Thèmes de recherche

His research focuses on the development of new tandem/domino reactions starting from simple molecules such as α-bromoacetamides and acrylamides for the synthesis of biologically relevant N-heterocycles.

3. Mots-clés

Domino and tandem reactions, methodology, N-heterocycles

4. Production Scientifique

Publications : 62

Chapitres de livre : 1

Conférences invitées: 5

Brevets: 2

Publications

Article dans une revue (41)

Straightforward Access to Polyfunctionalized δ-Lactams via Domino Aza–Michael/Thia–Michael/Aldol Sequence Axelle Genty,Ismail Alahyen,Marie-José Tranchant,Jérôme Lhoste,Vincent Dallaet al. Molecules, 2025, 30 (10), pp.2154. ⟨10.3390/molecules30102154⟩ Article dans une revue hal-05067699v1
Iron-Catalyzed oxidation of triol containing vicinal diols into hydroxy lactones: A DFT Study David Branquet,Fabian Cuffel,Sébastien Comesse,Arnaud Martel,Laure Benhamou Journal of Organic Chemistry, 2025, 90 (41), pp.14464-14470. ⟨10.1021/acs.joc.5c01279⟩ Article dans une revue hal-05491802v2
N -benzyloxyacrylamides as bisnucleophiles in an organocatalyzed domino aza-Michael/Morita-Baylis-Hillman sequence Ismail Alahyen,Catherine Taillier,Jérôme Lhoste,Vincent Dalla,Sébastien Comesse Organic Letters, In press, ⟨10.1021/acs.orglett.4c00295⟩ Article dans une revue hal-04481372v1
2,3‐Epoxyamide‐alcohols in Domino Reactions: En Route to Molecular Diversity Abderrahman El Bouakher,Jérôme Lhoste,Arnaud Martel,Sébastien Comesse ChemistryOpen, 2024, 13 (9), pp.e202400115. ⟨10.1002/open.202400115⟩ Article dans une revue hal-04578270v1
Unlocking the C-centered ring-opening of phosphiranium ions for a straightforward entry to functionalized phosphines Mohammad Ahmad,Marie-José Tranchant,Sébastien Comesse,Nathalie Saffon-Merceron,Julien Pilméet al. Nature Communications, 2024, 15 (1), pp.8554. ⟨10.1038/s41467-024-53003-z⟩ Article dans une revue hal-04723930v1
Probing N-Alkoxy Effects in Domino Reactions of α-Bromoacetamide Derivatives Towards Functionalized γ-Lactams Philippe Champetter,Ismail Alahyen,Catherine Taillier,Jean-François Brière,Vincent Dallaet al. ChemistrySelect, 2022, 7 (38), ⟨10.1002/slct.202203305⟩ Article dans une revue hal-03808493v1
Access to Stable Quaternary Phosphiranium Salts by P-Alkylation and P-Arylation of Phosphiranes Julien Gasnot,Clément Botella,Sébastien Comesse,Sami Lakhdar,Carole Alayracet al. SYNLETT, 2020, 31 (09), pp.883-888. ⟨10.1055/s-0040-1708000⟩ Article dans une revue hal-02899695v1
Synergy between pristine and hydrophobically modified xanthans for stabilizing oil-in-water emulsions Céline Fantou,Jiseon Yoo,Sébastien COMESSE,Michel Grisel,Frédéric Renou Colloid and Interface Science Communications, 2020, 37, pp.100292. ⟨10.1016/j.colcom.2020.100292⟩ Article dans une revue hal-04687536v1
Taming the Reactivity of Phosphiranium Salts: Site‐Selective C‐Centered Ring Opening for Direct Synthesis of Phosphinoethylamines Julien Gasnot,Clément Botella,Sébastien Comesse,Sami Lakhdar,Carole Alayracet al. Angewandte Chemie International Edition, 2020, 59 (29), pp.11769-11773. ⟨10.1002/anie.201916449⟩ Article dans une revue hal-02899688v1
α-Halogenoacetamides: versatile and efficient tools for the synthesis of complex aza-heterocycles Abderrahman El Bouakher,Arnaud Martel,Sébastien Comesse Organic & Biomolecular Chemistry, 2019, 17 (37), pp.8467-8485. ⟨10.1039/C9OB01683J⟩ Article dans une revue hal-02313870v1
Impact of backbone stiffness and hydrophobic chain length of modified xanthan on oil in water emulsion stabilization Céline Fantou,Sébastien Comesse,Frédéric F. Renou,Michel Grisel Carbohydrate Polymers, 2019, 216, pp.352-359. ⟨10.1016/j.carbpol.2019.03.079⟩ Article dans une revue istex hal-02181669v1
Chemo-, Regio-, and Stereoselective Synthesis of Polysusbtituted Oxazolo[3,2- d ][1,4]oxazepin-5(3 H )ones via a Domino oxa-Michael/aza-Michael/Williamson Cycloetherification Sequence Abderrahman El Bouakher,Jordan Tasserie,Ronan Le Goff,Jérôme Lhoste,Arnaud Martelet al. Journal of Organic Chemistry, 2017, 82 (11), pp.5798-5809. ⟨10.1021/acs.joc.7b00629⟩ Article dans une revue hal-01912420v1
Chemical modification of xanthan in the ordered and disordered states: An open route for tuning the physico-chemical properties Céline Fantou,Audrey Roy,Emmanuelle Dé,Sébastien Comesse,Michel Griselet al. Carbohydrate Polymers, 2017, 178, pp.115-122. ⟨10.1016/j.carbpol.2017.09.039⟩ Article dans une revue hal-02181629v1
Bi(OTf) 3 -Catalysed Access to 2,3-Substituted Isoindolinones and Tricyclic N,O-Acetals by Trapping of Bis- N -Acyliminium Species in a Tandem Process Ahmed Aliyenne,Frédéric Pin,Vijaykumar Nimbarte,Ata Martin Lawson,Sébastien Comesseet al. European Journal of Organic Chemistry, 2016, 2016 (21), pp.3592-3602. ⟨10.1002/ejoc.201600530⟩ Article dans une revue istex hal-01928678v1
Synthesis of Oxazolidin-4-ones: Domino O -Alkylation/Aza-Michael/Intramolecular Retro-Claisen Condensation Abderrahman El Bouakher,Ronan Le Goff,Jordan Tasserie,Jérôme Lhoste,Arnaud Martelet al. Organic Letters, 2016, 18 (10), pp.2383-2386. ⟨10.1021/acs.orglett.6b00851⟩ Article dans une revue hal-01912406v1
An Unprecedented Straightforward Synthesis of Chiral Pyrrolo[3,4- b ]quinolone and Pyrrolo[3,2- b ]quinolone Backbones Starting from trans -4-Hydroxy-L-proline Sébastien Comesse,Adam Daïch Journal of Chemistry , 2016, 2016, pp.1-5. ⟨10.1155/2016/1504682⟩ Article dans une revue hal-02331437v1
Expeditious Synthesis of the Topoisomerase I Inhibitors Isoindolo[2,1-b]isoquinolin-7(5H)-one and the Alkaloid Rosettacin Based on Aryl Radical Cyclization of Enamide Generated by Using N-Acyl­iminium Chemistry Ata Martin Lawson,Lahssen El Blidi,Aurélie Namoune,Alexandre Bridoux,Vijaykumar Nimbarteet al. Synthesis: Journal of Synthetic Organic Chemistry, 2015, 47 (22), pp.3583-3592. ⟨10.1055/s-0034-1378811⟩ Article dans une revue hal-02332633v1
Highly Stereoselective Domino Oxa-Michael/Aza-Michael/Cyclization Synthesis of Bicyclic Lactams and Spirooxindole Skeleton R. Le Goff,M. Sanselme,Ata Martin Lawson,Adam Daïch,Sébastien Comesse European Journal of Organic Chemistry, 2015, 2015 (33), pp.7244-7248. ⟨10.1002/ejoc.201501072⟩ Article dans une revue istex hal-02413286v1
Simple Access to Highly Functional Bicyclic γ- and δ-Lactams: Origins of Chirality Transfer to Contiguous Tertiary/Quaternary Stereocenters Assessed by DFT Ronan Le goff,Arnaud Martel,Morgane Sanselme,Ata Martin Lawson,Adam Daïchet al. Chemistry - A European Journal, 2015, 21 (7), pp.2966-2979. ⟨10.1002/chem.201405094⟩ Article dans une revue istex hal-01929393v1
Hydrophobically Modified Xanthan: An Amphiphilic but Not Associative Polymer Audrey Roy,Sébastien Comesse,Michel Grisel,Nicolas Hucher,Zied Souguiret al. Biomacromolecules, 2014, 15 (4), pp.1160-1170. ⟨10.1021/bm4017034⟩ Article dans une revue hal-02163442v1
Synthesis of highly functionalized pyrrolidines as tunable templates for the direct access to (±)-coerulescine and the tricyclic core of martinellines Ronan Le Goff,Ata Martin Lawson,Adam Daïch,Sébastien Comesse Organic & Biomolecular Chemistry, 2013, 11 (11), pp.1818. ⟨10.1039/c3ob27472a⟩ Article dans une revue hal-02332622v1
A versatile domino process for the synthesis of substituted 3-aminomethylene-chromanones and 2-pyridones catalyzed by CsF Catalin Pintiala,Ata Martin Lawson,Sébastien Comesse,Adam Daïch Tetrahedron Letters, 2013, 54 (22), pp.2853-2857. ⟨10.1016/j.tetlet.2013.03.096⟩ Article dans une revue hal-02564869v1
Tandem aza-Michael/spiro-ring closure sequence: access to a versatile scaffold and total synthesis of (±)-coerulescine Meral Görmen,Ronan Le Goff,Ata Martin Lawson,Adam Daïch,Sébastien Comesse Tetrahedron Letters, 2013, 54 (17), pp.2174-2176. ⟨10.1016/j.tetlet.2013.02.047⟩ Article dans une revue istex hal-02564870v1
Diastereoselective Access to Tri- and Pentacyclic Spiro-γ-lactam-oxindole Cores through a Tandem Aza-Michael Initiated Ring Closure Sequence Iyad Allous,Sébastien Comesse,Morgane Sanselme,Adam Daïch European Journal of Organic Chemistry, 2011, 2011 (27), pp.5303 - 5310. ⟨10.1002/ejoc.201100731⟩ Article dans une revue istex hal-01931220v1
Intramolecular N-aza-amidoalkylation in association with Witkop–Winterfeldt oxidation as the key step to synthesize Luotonin-A analogues Frédéric Pin,Sébastien Comesse,Adam Daïch Tetrahedron, 2011, 67 (31), pp.5564-5571. ⟨10.1016/j.tet.2011.05.120⟩ Article dans une revue hal-02564879v1
Domino Process Optimized via ab Initio Study for an Alternative Access to Bicyclic Lactams Sébastien Comesse,Arnaud Martel,Adam Daïch Organic Letters, 2011, 13 (15), pp.4004-4007. ⟨10.1021/ol2015225⟩ Article dans une revue hal-00661218v1
Proximal Ester Assistance vs. Stereoelectronic Prohibition in Catalytic N-Acyliminium Ion Reactions: Stereoselective Formation of Aza-Heterocycles with Two Contiguous Quaternary-Tertiary Stereocenters Moussa Saber,Sébastien Comesse,Vincent Dalla,Pierre Netchitaïlo,Adam Daïch SYNLETT, 2011, 2011 (16), pp.2425-2429. ⟨10.1055/s-0030-1260311⟩ Article dans une revue hal-02564874v1
Formal [3+2]-Cycloaddition-Based Approach Using Ethoxymethylene Malonate Derivatives: Novel and Expedient Access to Functionalized N-Acyliminium Precursors Moussa Saber,Sébastien Comesse,Vincent Dalla,Adam Daïch,Morgane Sanselmeet al. SYNLETT, 2010, 2010 (14), pp.2197-2201. ⟨10.1055/s-0030-1258530⟩ Article dans une revue hal-02564898v1
Regioselective ring opening of the chiral non-racemic furoindolizidinols. New entry to alkylindolizidinediol derivatives Peter Šafář,Jozefína Žúžiová,Eva Tóthová,Štefan Marchalín,Nadežda Prónayováet al. Tetrahedron: Asymmetry, 2010, 21 (5), pp.623-630. ⟨10.1016/j.tetasy.2010.03.018⟩ Article dans une revue istex hal-02564901v1
Toward the improvement of the tandem halide displacement/amide coupling spiro-cyclization as a new route to γ-lactam and pyrroloisoquinoline templates Iyad Allous,Sébastien Comesse,Dušan Berkeš,Amar Alkyat,Adam Daïch Tetrahedron Letters, 2009, 50 (31), pp.4411-4415. ⟨10.1016/j.tetlet.2009.02.114⟩ Article dans une revue istex hal-02564909v1
Unexpected reversible nitrogen atom transfer in the synthesis of polysubstituted imides and 7-aza-hexahydroindolones via enaminonitrile γ-lactams Nabila Oukli,Sébastien Comesse,Nafa Chafi,Hassan Oulyadi,Adam Daïch Tetrahedron Letters, 2009, 50 (13), pp.1459-1462. ⟨10.1016/j.tetlet.2009.01.072⟩ Article dans une revue hal-02564911v1
Association of Intramolecular Furan Diels-Alder Reaction and N-Acylim­­i­n­ium Alkylation for the Synthesis of Pentacyclic Precursor of Aromathecins Frédéric Pin,Sébastien Comesse,Adam Daïch SYNLETT, 2009, 2009 (19), pp.3214-3218. ⟨10.1055/s-0029-1218300⟩ Article dans une revue hal-02564904v1
An Enantioselective Approach to Synthesis of Advanced Chiral Templates for the Construction of Indolic and Indolizidinic Alkaloids Sébastien Comesse,Adam Daïch,Catherine Kadouri-Puchot,Radouane Affani,Louis Hamon Heterocycles, 2009, 78 (9), pp.2193. ⟨10.3987/COM-09-11690⟩ Article dans une revue hal-02564906v1
Synthesis and reductive desulfurization of chiral non-racemic benzothienoindolizines. An efficient approach to a novel bioactive tylophorine alkaloid analogue and 6-phenylindolizidine Peter Šafář,Jozefína Žúžiová,Mária Bobošíková,Štefan Marchalín,Nadežda Prónayováet al. Tetrahedron: Asymmetry, 2009, 20 (18), pp.2137-2144. ⟨10.1016/j.tetasy.2009.08.010⟩ Article dans une revue istex hal-02564905v1
Highly diastereoselective approach to novel tetrahydrofuran-fused indolizidinols: a one-step formation of three contiguous stereocenters Frédéric Pin,Sébastien Comesse,Morgane Sanselme,Peter Šafář,Jozefína Žúžiováet al. Tetrahedron: Asymmetry, 2008, 19 (4), pp.467-475. ⟨10.1016/j.tetasy.2008.01.013⟩ Article dans une revue istex hal-02564921v1
New and Expeditious Tandem Sequence Aza-Michael/Intramolecular Nucleophilic Substitution Route to Substituted γ-Lactams: Synthesis of the Tricyclic Core of (±)-Martinellines Sébastien Comesse,Morgane Sanselme,Adam Daïch Journal of Organic Chemistry, 2008, 73 (14), pp.5566 - 5569. ⟨10.1021/jo702752w⟩ Article dans une revue istex hal-01933027v1
A Domino N-Amidoacylation/Aldol-Type Condensation Approach to the Synthesis of the Topo-I Inhibitor Rosettacin and Derivatives † Frédéric Pin,Sébastien Comesse,Morgane Sanselme,Adam Daïch Journal of Organic Chemistry, 2008, 73 (5), pp.1975 - 1978. ⟨10.1021/jo702387q⟩ Article dans une revue istex hal-01933035v1
An Unusual Polyheterocyclic Diversity by the π-Cyclisation of N -Carbamoyl­iminium Ion, with or without Tandem N , N -Acetal Cleavage, from Spiro(imidazolidinoquinazolinones) Sébastien Comesse,Morgane Sanselme,Adam Daïch,Anthony Pesquet,Adam Daïchet al. Synthesis: Journal of Synthetic Organic Chemistry, 2008, 2008 (9), pp.1389-1396. ⟨10.1055/s-2008-1067032⟩ Article dans une revue hal-02564919v1
A Novel and Expeditious Approach to Symmetrical and Unsymmetrical 5,5-Spiroimide Building Blocks Adam Daïch,Iyad Allous,Sébastien Comesse Letters in Organic Chemistry, 2008, 5 (2), pp.73-78. ⟨10.2174/157017808783743902⟩ Article dans une revue hal-02564922v1
Intermolecular and Intramolecular α-Amidoalkylation Reactions Using Bismuth Triflate as the Catalyst Frédéric Pin,Sébastien Comesse,Bernard Garrigues,Štefan Marchalín,Adam Daïch Journal of Organic Chemistry, 2007, 72 (4), pp.1181-1191. ⟨10.1021/jo062077x⟩ Article dans une revue istex hal-02564926v1
On the Synthesis and Reactivity of Enantiopure Azetidines Emilie Banide,Vincent Lemau de Talancé,Grégory Schmidt,Hodney Lubin,Sébastien COMESSEet al. European Journal of Organic Chemistry, 2007, 2007 (27), pp.4517-4524. ⟨10.1002/ejoc.200700283⟩ Article dans une revue istex hal-04687530v1