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Publications

Pré-publication, Document de travail (4)

Slap restricts oncogenic Src-family kinase signaling to maintain colonic epithelial homeostasis Dana Naim,Zouheir Houhou,Florent Cauchois,Valerie Simon,Francina Langa Viveset al. 2026 Pré-publication, Document de travail (preprint/prepublication) hal-05446031v1
SLAP controls mTORC2 integrity via UBE3C-mediated mLST8 ubiquitination to mediate its tumour suppressive function in colorectal cancer Rudy Mevizou,Dana Naim,Florent Cauchois,Cécile Naudin,Georgia Greaveset al. 2025 Pré-publication, Document de travail hal-05380083v1
SHED-dependent oncogenic signalling of the PEAK3 pseudo-kinase Youcef Ounoughene,Elise Fourgous,Yvan Boublik,Estelle Saland,Nathan Guiraudet al. 2021 Pré-publication, Document de travail hal-03369637v1
Regulation of Src tumor activity by its N-terminal intrinsically disordered region Emilie Aponte,Marie Lafitte,Audrey Sirvent,Valerie Simon,Maud Barberyet al. 2021 Pré-publication, Document de travail hal-03369660v1

Article dans une revue (41)

SLAP controls mTORC2 integrity via UBE3C-mediated non-degradative mLST8 ubiquitination to suppress colorectal tumorigenesis Rudy Mevizou,Dana Naim,Florent Cauchois,Cécile Naudin,Georgia Greaveset al. Cell Death and Differentiation, In press, Online ahead of print. ⟨10.1038/s41418-025-01633-1⟩ Article dans une revue hal-05421846v1
Lipid-driven Src self-association modulates its transformation capacity Irrem-Laareb Mohammad,Marina I Giannotti,Elise Fourgous,Yvan Boublik,Alejandro Fernándezet al. Life Science Alliance, 2025, 8 (5), pp.e202403019. ⟨10.26508/lsa.202403019⟩ Article dans une revue hal-05317927v1
Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR Julie Nguyen,Marie Lafitte,Maud Barbery,Kevin Espie,Maya Jeitanyet al. Advanced Science, In press, 12 (38), pp.e02136. ⟨10.1002/advs.202502136⟩ Article dans une revue hal-05213630v1
Regulation of Src tumor activity by its N-terminal intrinsically disordered region Emilie Aponte,Marie Lafitte,Audrey Sirvent,Valérie Simon,Maud Barberyet al. Oncogene, 2022, 41 (7), pp.960-970. ⟨10.1038/s41388-021-02092-x⟩ Article dans une revue hal-03523417v1
Oncogenic Signalling of PEAK2 Pseudokinase in Colon Cancer Céline Lecointre,Elise Fourgous,Ingrid Montarras,Clément Kerneur,Valérie Simonet al. Cancers, 2022, 14 (12), pp.2981. ⟨10.3390/cancers14122981⟩ Article dans une revue hal-05086826v1
New functions of DDR1 collagen receptor in tumor dormancy, immune exclusion and therapeutic resistance Audrey Sirvent,Kevin Espie,Evangelia Papadopoulou,Dana Naim,Serge Roche Frontiers in Oncology, 2022, 12, pp.956926. ⟨10.3389/fonc.2022.956926⟩ Article dans une revue hal-03830459v1
SHED-Dependent Oncogenic Signaling of the PEAK3 Pseudo-Kinase Youcef Ounoughene,Elise Fourgous,Yvan Boublik,Estelle Saland,Nathan Guiraudet al. Cancers, 2021, 13 (24), pp.6344. ⟨10.3390/cancers13246344⟩ Article dans une revue hal-03515387v1
Src Family Tyrosine Kinases in Intestinal Homeostasis, Regeneration and Tumorigenesis Audrey Sirvent,Rudy Mevizou,Dana Naim,Marie Lafitte,Serge Roche Cancers, 2020, 12 (8), pp.2014. ⟨10.3390/cancers12082014⟩ Article dans une revue hal-02989641v1
Collagen Kinase Receptors as Potential Therapeutic Targets in Metastatic Colon Cancer Marie Lafitte,Audrey Sirvent,Serge Roche Frontiers in Oncology, 2020, 10, ⟨10.3389/fonc.2020.00125⟩ Article dans une revue hal-02989658v1
Roles of exosomes in metastatic colorectal cancer Marie Lafitte,Céline Lecointre,Serge Roche American Journal of Physiology - Cell Physiology, 2019, 317 (5), pp.C869-C880. ⟨10.1152/ajpcell.00218.2019⟩ Article dans une revue hal-02339517v1
Control of Tyrosine Kinase Signalling by Small Adaptors in Colorectal Cancer Rudy Mevizou,Audrey Sirvent,Serge Roche Cancers, 2019, 11 (5), pp.669. ⟨10.3390/cancers11050669⟩ Article dans une revue hal-02339136v1
DDR1 inhibition as a new therapeutic strategy for colorectal cancer Audrey Sirvent,Marie Lafitte,Serge Roche Molecular & Cellular Oncology, 2018, 5 (4), ⟨10.1080/23723556.2018.1465882⟩ Article dans une revue hal-01905024v1
Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer Maya Jeitany,Cédric Leroy,Priscillia Tosti,Marie Lafitte,Jordy Le Guetet al. EMBO Molecular Medicine, 2018, 10 (4), pp.e7918. ⟨10.15252/emmm.201707918⟩ Article dans une revue hal-01872978v1
Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation Céline Lecointre,Valérie Simon,Clément Kerneur,Frédéric Allemand,Aurélie Fournetet al. Structure, 2018, 26 (4), pp.545-554.e4. ⟨10.1016/j.str.2018.01.017⟩ Article dans une revue hal-01872982v1
The Unique Domain Forms a Fuzzy Intramolecular Complex in Src Family Kinases Miguel Arbesú,Mariano Maffei,Tiago N. Cordeiro,João M.C. Teixeira,Yolanda Pérezet al. Structure, 2017, 25 (4), pp.630--640.e4. ⟨10.1016/j.str.2017.02.011⟩ Article dans une revue hal-01875247v1
Syntenin mediates SRC function in exosomal cell-to-cell communication Naga Sailaja Imjeti,Kerstin Menck,Antonio Luis Egea-Jimenez,Céline Lecointre,Frédérique Lemboet al. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (47), pp.12495 - 12500. ⟨10.1073/pnas.1713433114⟩ Article dans une revue hal-01765373v1
The role of small adaptor proteins in the control of oncogenic signaling driven by tyrosine kinases in human cancer Cécile Naudin,Clément Chevalier,Serge Roche Oncotarget, 2016, 7, pp.11033-11055. ⟨10.18632/oncotarget.6929⟩ Article dans une revue inserm-01292961v1
Vesicular trafficking regulators are new players in breast cancer progression: Role of TOM1L1 in ERBB2-dependent invasion Clément Chevalier,Serge Roche,Christine Bénistant Molecular & Cellular Oncology, 2016, 3 (4), pp.e1182241. ⟨10.1080/23723556.2016.1182241⟩ Article dans une revue hal-01878026v1
TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion Clément Chevalier,Guillaume Collin,Simon Descamps,Heiani Touaitahuata,Valérie Simonet al. Nature Communications, 2016, 7 (1), pp.10765. ⟨10.1038/ncomms10765⟩ Article dans une revue hal-01299292v1
YES oncogenic activity is specified by its SH4 domain and regulates RAS/MAPK signaling in colon carcinoma cells Fanny Dubois,Cédric Leroy,Valérie Simon,Christine Benistant,Serge Roche American Journal of Cancer Research, 2015, 5 (6), pp.1972--1987 Article dans une revue hal-01883466v1
The SH3 Domain Acts as a Scaffold for the N-Terminal Intrinsically Disordered Regions of c-Src Mariano Maffei,Miguel Arbesú,Anabel-Lise Le~roux,Irene Amata,Serge Rocheet al. Structure, 2015, 23 (5), pp.893--902. ⟨10.1016/j.str.2015.03.009⟩ Article dans une revue hal-01883500v1
Progastrin a new pro-angiogenic factor in colorectal cancer S Najib,A Kowalski-Chauvel,C Do,S Roche,E Cohen-Jonathan-Moyalet al. Oncogene, 2015, 34 (24), pp.3120--3130. ⟨10.1038/onc.2014.255⟩ Article dans une revue hal-01883491v1
ABL Tyrosine Kinase Inhibition Variable Effects on the Invasive Properties of Different Triple Negative Breast Cancer Cell Lines Clément Chevalier,Aude Cannet,Simon Descamps,Audrey Sirvent,Valérie Simonet al. PLoS ONE, 2015, 10 (3), pp.e0118854. ⟨10.1371/journal.pone.0118854⟩ Article dans une revue hal-01883471v1
CBL controls a tyrosine kinase network involving AXL, SYK and LYN in nilotinib-resistant chronic myeloid leukaemia: CBL controls kinase expression Romain Gioia,Claire Trégoat,Pierre-Yves Dumas,Valérie Lagarde,Valérie Prouzet-Mauléonet al. Journal of Pathology, 2015, 237 (1), pp.14--24. ⟨10.1002/path.4561⟩ Article dans une revue istex hal-01883494v1
Contribution of phosphoproteomics in understanding SRC signaling in normal and tumor cells Audrey Sirvent,Serge Urbach,Serge Roche Proteomics, 2015, 15 (2-3), pp.232--244. ⟨10.1002/pmic.201400162⟩ Article dans une revue istex hal-01883488v1
SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2 Cécile Naudin,Audrey Sirvent,Cédric Leroy,Romain Larive,Valérie Simonet al. Nature Communications, 2014, 5, pp.3159. ⟨10.1038/ncomms4159⟩ Article dans une revue hal-01944933v1
Analyse in vivo de la signalisation tumorale induite par les tyrosinekinases par protéomique quantitative Audrey Sirvent,Serge Urbach,Serge Roche Médecine/Sciences, 2014, 30 (5), pp.558--566. ⟨10.1051/medsci/20143005020⟩ Article dans une revue hal-01942937v1
The short form of RON is expressed in acute myeloid leukemia and sensitizes leukemic cells to cMET inhibitors C Fialin,C Larrue,F Vergez,J Sarry,S Bertoliet al. Leukemia, 2012, 27 (2), pp.325-335. ⟨10.1038/leu.2012.240⟩ Article dans une revue hal-04784565v1
Specific Oncogenic Activity of the Src-Family Tyrosine Kinase c-Yes in Colon Carcinoma Cells. Florence Sancier,Aurélie Dumont,Audrey Sirvent,Ludmilla Paquay de Plater,Thomas Edmondset al. PLoS ONE, 2011, 6 (2), pp.e17237. ⟨10.1371/journal.pone.0017237⟩ Article dans une revue hal-00581348v1
Src family tyrosine kinases-driven colon cancer cell invasion is induced by Csk membrane delocalization. Audrey Sirvent,C. Bénistant,Julie Pannequin,L. Veracini,V. Simonet al. Oncogene, 2010, 29 (9), pp.1303-15. ⟨10.1038/onc.2009.450⟩ Article dans une revue hal-00443776v1
Quantitative phosphoproteomics reveals a cluster of tyrosine kinases that mediates SRC invasive activity in advanced colon carcinoma cells. Cédric Leroy,Camille Fialin,Audrey Sirvent,Valérie Simon,Serge Urbachet al. Cancer Research, 2009, 69 (6), pp.2279-86. ⟨10.1158/0008-5472.CAN-08-2354⟩ Article dans une revue hal-00367875v1
Evidence that Resistance to Nilotinib May Be Due to BCR-ABL, Pgp, or Src Kinase Overexpression François-Xavier Mahon,Sandrine Hayette,Valérie Lagarde,Francis Belloc,Béatrice Turcqet al. Cancer Research, 2008, 68 (23), pp.9809-9816. ⟨10.1158/0008-5472.CAN-08-1008⟩ Article dans une revue hal-03155362v1
Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells. Audrey Sirvent,Christine Benistant,Serge Roche Biology of the Cell, 2008, 100 (11), pp.617-31. ⟨10.1042/BC20080020⟩ Article dans une revue hal-00346793v1
The Src-like adaptor protein regulates PDGF-induced actin dorsal ruffles in a c-Cbl-dependent manner. Audrey Sirvent,C. Leroy,A. Boureux,V. Simon,Serge Roche Oncogene, 2008, 27 (24), pp.3494-500. ⟨10.1038/sj.onc.1211011⟩ Article dans une revue hal-00211547v1
The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1. Laurence Veracini,Valérie Simon,Véronique Richard,Burkhart Schraven,Vaclav Horejsiet al. Journal of Cell Biology, 2008, 182 (3), pp.603-14. ⟨10.1083/jcb.200705102⟩ Article dans une revue hal-00348407v1
The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells. Audrey Sirvent,A. Boureux,V. Simon,C. Leroy,Serge Roche Oncogene, 2007, 26 (52), pp.7313-7323. ⟨10.1038/sj.onc.1210543⟩ Article dans une revue hal-00189107v1
The Tom1L1-clathrin heavy chain complex regulates membrane partitioning of the tyrosine kinase Src required for mitogenic and transforming activities. Guillaume Collin,Mélanie Franco,Valérie Simon,Christine Bénistant,Serge Roche Molecular and Cellular Biology, 2007, 27 (21), pp.7631-40. ⟨10.1128/MCB.00543-07⟩ Article dans une revue hal-00189124v1
A Function for Phosphoinositide 3-Kinase β Lipid Products in Coupling βγ to Ras Activation in Response to Lysophosphatidic Acid Armelle Yart,Serge Roche,Reinhard Wetzker,Muriel Laffargue,Nicholas Tonkset al. Journal of Biological Chemistry, 2002, 277 (24), pp.21167-21178. ⟨10.1074/jbc.M110411200⟩ Article dans une revue hal-03191860v1
A Critical Role for Phosphoinositide 3-Kinase Upstream of Gab1 and SHP2 in the Activation of Ras and Mitogen-activated Protein Kinases by Epidermal Growth Factor Armelle Yart,Muriel Laffargue,Patrick Mayeux,Stany Chretien,Christine Pérèset al. Journal of Biological Chemistry, 2001, 276 (12), pp.8856-8864. ⟨10.1074/jbc.M006966200⟩ Article dans une revue hal-03191837v1
An Epidermal Growth Factor Receptor/Gab1 Signaling Pathway Is Required for Activation of Phosphoinositide 3-Kinase by Lysophosphatidic Acid Muriel Laffargue,Patrick Raynal,Armelle Yart,Christine Pérès,Bernard Payrastreet al. Journal of Biological Chemistry, 1999, 274 (46), pp.32835-32841. ⟨10.1074/jbc.274.46.32835⟩ Article dans une revue hal-03192161v1
A Function for Phosphatidylinositol 3-Kinase β (p85α-p110β) in Fibroblasts during Mitogenesis: Requirement for Insulin- and Lysophosphatidic Acid-Mediated Signal Transduction Serge Roche,J. Downward,Patrick Raynal,Sara Courtneidge Molecular and Cellular Biology, 1998, 18 (12), pp.7119-7129. ⟨10.1128/MCB.18.12.7119⟩ Article dans une revue hal-03191846v1