Séverine Denoyelle

Publications

Article dans une revue (32)

Novel insights into the effects of JMV2894, a growth hormone secretagogue, in Duchenne muscular dystrophy: A preclinical study in the D2-mdx mouse model Paola Mantuano,Brigida Boccanegra,Manuel Marinelli,Enrica Cristiano,Roberta Lentiet al. Biomedicine and Pharmacotherapy, 2025, 193, pp.118767. ⟨10.1016/j.biopha.2025.118767⟩ Article dans une revue hal-05509003v1
From Design to Outcome: The Role of Bi‐ and Multifunctional Ligands in Modern Therapeutics Célia Bouacha,Séverine Denoyelle,Sonia Cantel Advanced Therapeutics, 2025, 8 (10), ⟨10.1002/adtp.202500146⟩ Article dans une revue hal-05509035v1
Role of symmetry in 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as inhibitors of translation initiation Hongwei Yang,Ting Chen,Séverine Denoyelle,Limo Chen,Jing Fanet al. Bioorganic and Medicinal Chemistry Letters, 2023, 80, pp.129119. ⟨10.1016/j.bmcl.2022.129119⟩ Article dans une revue hal-04119175v1
Growth hormone secretagogues modulate inflammation and fibrosis in mdx mouse model of Duchenne muscular dystrophy Brigida Boccanegra,Ornella Cappellari,Paola Mantuano,Daniela Trisciuzzi,Antonietta Meleet al. Frontiers in Immunology, 2023, 14, pp.1119888. ⟨10.3389/fimmu.2023.1119888⟩ Article dans une revue hal-04121024v1
Design and characterization of a triazole-based growth hormone secretagogue receptor modulator inhibiting the glucoregulatory and feeding actions of ghrelin Sylvie Péraldi-Roux,Morgane Bayle,Céline M'Kadmi,Marjorie Damian,Justine Vailléet al. Biochemical Pharmacology, 2022, 202, ⟨10.1016/j.bcp.2022.115114⟩ Article dans une revue hal-03813988v1
GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner Gimena Fernandez,Agustina Cabral,Pablo Nicolás de Francesco,Maia Uriarte,Mirta Reynaldoet al. Cellular and Molecular Life Sciences, 2022, 79 (5), pp.277. ⟨10.1007/s00018-022-04302-5⟩ Article dans une revue hal-04687046v1
A Novel Truncated Liver Enriched Antimicrobial Peptide-2 Palmitoylated at its N-Terminal Antagonizes Effects of Ghrelin Lucie Holá,Blanka Železná,Alena Karnošová,Jaroslav Kuneš,Jean-Alain Fehrentzet al. Journal of Pharmacology and Experimental Therapeutics, 2022, 383 (2), pp.129-136. ⟨10.1124/jpet.122.001322⟩ Article dans une revue hal-04119343v1
Allosteric modulation of ghrelin receptor signaling by lipids Marjorie Damian,Maxime Louet,Antoniel Augusto Severo Gomes,Céline M’kadmi,Séverine Denoyelleet al. Nature Communications, 2021, 12 (1), pp.3938. ⟨10.1038/s41467-021-23756-y⟩ Article dans une revue hal-03407522v1
Allosteric modulation of ghrelin receptor signaling by lipids Marjorie Damian,Maxime Louet,Antoniel Augusto Severo Gomes,Céline M’kadmi,Séverine Denoyelleet al. Nature Communications, 2021, 12 (1), pp.3938. ⟨10.1038/s41467-021-23756-y⟩ Article dans une revue hal-03852471v1
Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor Maxime Louet,Marina Casiraghi,Marjorie Damian,Mauricio Gs Costa,Pedro Renaultet al. eLife, 2021, 10, pp.e63201. ⟨10.7554/elife.63201⟩ Article dans une revue hal-03407524v1
Circulating ghrelin crosses the blood-cerebrospinal fluid barrier via growth hormone secretagogue receptor dependent and independent mechanisms Maia Uriarte,Pablo de Francesco,Gimena Fernández,Daniel Castrogiovanni,Micaela d'Arcangeloet al. Molecular and Cellular Endocrinology, 2021, 538, pp.111449. ⟨10.1016/j.mce.2021.111449⟩ Article dans une revue hal-04614605v1
LEAP2 Impairs the Capability of the Growth Hormone Secretagogue Receptor to Regulate the Dopamine 2 Receptor Signaling Emilio Mustafá,Santiago Cordisco González,Marjorie Damian,Sonia Cantel,Severine Denoyelleet al. Frontiers in Pharmacology, 2021, 12, pp.712437. ⟨10.3389/fphar.2021.712437⟩ Article dans une revue hal-03382623v1
Development of non-peptidic inverse agonists of the ghrelin receptor (GHSR) based on the 1,2,4-triazole scaffold Khoubaib Ben Haj Salah,Mathieu Maingot,Anne-Laure Blayo,Céline M'Kadmi,Marjorie Damianet al. Journal of Medicinal Chemistry, 2020, 63 (19), pp.10796-10815. ⟨10.1021/acs.jmedchem.9b02122⟩ Article dans une revue hal-03027489v1
Development of a novel fluorescent ligand of growth hormone secretagogue receptor based on the N-Terminal Leap2 region Franco Barrile,Céline M'Kadmi,Pablo de Francesco,Agustina Cabral,Guadalupe García Romeroet al. Molecular and Cellular Endocrinology, 2019, 498, pp.110573. ⟨10.1016/j.mce.2019.110573⟩ Article dans une revue hal-02375522v1
N-Terminal Liver-Expressed Antimicrobial Peptide 2 (LEAP2) Region Exhibits Inverse Agonist Activity toward the Ghrelin Receptor Céline M'Kadmi,Agustina Cabral,Franco Barrile,Julien Giribaldi,Sonia Cantelet al. Journal of Medicinal Chemistry, 2019, 62 (2), pp.965-973. ⟨10.1021/acs.jmedchem.8b01644⟩ Article dans une revue hal-02307053v1
Evaluation of amidoxime derivatives as prodrug candidates of potent bis-cationic antimalarials Olivier Berger,Stéphanie Ortial,Sharon Wein,Séverine Denoyelle,Françoise Bressolleet al. Bioorganic and Medicinal Chemistry Letters, 2019, 29, pp.2203 - 2207. ⟨10.1016/j.bmcl.2019.06.045⟩ Article dans une revue hal-03488325v1
GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation Marjorie Damian,Véronique Pons,Pedro Renault,Céline M’kadmi,Bartholomé Delortet al. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (17), pp.4501-4506. ⟨10.1073/pnas.1712725115⟩ Article dans une revue hal-02322168v1
Synthesis of [1,2,4]Triazolo[4,3- a ]piperazin-6-ones: An Approach to the Triazole-Fused Ketopiperazine Scaffold Khoubaib Ben Haj Salah,Baptiste Legrand,Mathieu Bibian,Emmanuel Wenger,Jean-Alain Fehrentzet al. Organic Letters, 2018, 20 (11), pp.3250-3254. ⟨10.1021/acs.orglett.8b01112⟩ Article dans une revue hal-02871181v1
New ligands of the ghrelin receptor based on the 1,2,4-triazole scaffold by introduction of a second chiral center Mathieu Maingot,Anne-Laure Blayo,Severine Denoyelle,Céline M’kadmi,Marjorie Damianet al. Bioorganic and Medicinal Chemistry Letters, 2016, 26 (10), pp.2408-2412. ⟨10.1016/j.bmcl.2016.04.003⟩ Article dans une revue hal-02871896v1
Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling Céline M'Kadmi,Jean-Philippe Leyris,Lauriane Onfroy,Céline Galés,Aude Saulièreet al. Journal of Biological Chemistry, 2015, 290 (45), pp.27021-27039. ⟨10.1074/jbc.M115.659250⟩ Article dans une revue hal-03564155v1
Synthesis of Thieno[3,2- e ][1,4]diazepin-2-ones: Application of an Uncatalysed Pictet-Spengler Reaction Séverine Denoyelle,Guillaume Tambutet,Nicolas Masurier,Ludovic Maillard,Jean Martinezet al. European Journal of Organic Chemistry, 2015, 2015 (32), pp.7146-7153. ⟨10.1002/ejoc.201500943⟩ Article dans une revue istex hal-03563932v1
New trisubstituted 1,2,4-triazoles as ghrelin receptor antagonists. Anne-Laure Blayo,Mathieu Maingot,Babette Aicher,Céline M'Kadmi,Peter Schmidtet al. Bioorganic and Medicinal Chemistry Letters, 2015, 25 (1), pp.20-24. ⟨10.1016/j.bmcl.2014.11.031⟩ Article dans une revue istex hal-01090274v1
The 1,2,4-triazole as a scaffold for the design of ghrelin receptor ligands: development of JMV 2959, a potent antagonist Aline Moulin,Luc Brunel,Damien Boeglin,Luc Demange,Johanne Ryanet al. Amino Acids, 2013, 44 (2), pp.301-314. ⟨10.1007/s00726-012-1355-2⟩ Article dans une revue istex hal-02871938v1
Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors Séverine Denoyelle,Ting Chen,Hongwei Yang,Limo Chen,Yingzhen Zhanget al. European Journal of Medicinal Chemistry, 2013, 69, pp.537-553. ⟨10.1016/j.ejmech.2013.08.030⟩ Article dans une revue istex hal-03562672v1
Tumor suppression by small molecule inhibitors of translation initiation Limo Chen,Bertal Aktas,Yibo Wang,Xiaoying He,Rupam Sahooet al. Oncotarget, 2012, 3 (8), pp.869-881. ⟨10.18632/oncotarget.598⟩ Article dans une revue hal-04121321v1
In vitro inhibition of translation initiation by N,N′-diarylureas—potential anti-cancer agents Séverine Denoyelle,Ting Chen,Limo Chen,Yibo Wang,Edvin Klosiet al. Bioorganic and Medicinal Chemistry Letters, 2012, 22 (1), pp.402-409. ⟨10.1016/j.bmcl.2011.10.126⟩ Article dans une revue hal-04118217v1
Selective C-Acylation of 2-Aminoimidazo[1,2- a ]pyridine: Application to the Synthesis of Imidazopyridine-Fused [1,3]Diazepinones Nicolas Masurier,Roberta Aruta,Vincent Gaumet,Séverine Denoyelle,Emmanuel Moreauet al. Journal of Organic Chemistry, 2012, 77 (7), pp.3679 - 3685. ⟨10.1021/jo300364d⟩ Article dans une revue hal-01677551v1
Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target Ting Chen,Duygu Ozel,Yuan Qiao,Fred Harbinski,Limo Chenet al. Nature Chemical Biology, 2011, 7 (9), pp.610-616. ⟨10.1038/nchembio.613⟩ Article dans une revue hal-04119403v1
Synthesis and evaluation of hybrid bis-cationic salts as antimalarial drugs Stéphanie Ortial,Severine Denoyelle,Sharon Wein,Olivier Berger,Thierry Durandet al. ChemMedChem, 2010, 5 (1), pp.52-55. ⟨10.1002/cmdc.200900427⟩ Article dans une revue hal-00448020v1
A structure–activity investigation of hemifluorinated bifunctional bolaamphiphiles designed for gene delivery Mélanie Brunelle,Ange Polidori,Séverine Denoyelle,Anne-Sylvie Fabiano,Pascal Vuillaumeet al. Comptes Rendus. Chimie, 2009, 12 (1-2), pp.188-208. ⟨10.1016/j.crci.2008.05.018⟩ Article dans une revue istex hal-04119298v1
Design and synthesis of amidoxime derivatives for orally potent C-alkylamidine-based antimalarial agents Mahama Ouattara,Sharon Wein,Séverine Denoyelle,Stéphanie Ortial,Thierry Durandet al. Bioorganic and Medicinal Chemistry Letters, 2009, 19 (3), pp.624-626. ⟨10.1016/j.bmcl.2008.12.058⟩ Article dans une revue istex hal-03530218v1
Synthesis and preliminary biological studies of hemifluorinated bifunctional bolaamphiphiles designed for gene delivery Séverine Denoyelle,Ange Polidori,Mélanie Brunelle,Pascal Vuillaume,Sylvette Laurentet al. New Journal of Chemistry, 2006, 30 (4), pp.629. ⟨10.1039/b513944a⟩ Article dans une revue istex hal-04119479v1

Communication dans un congrès (7)

Development of potent GHSR inverse agonists: promising compounds for the treatment of obesity-related metabolic disorders Khoubaib Ben Haj Salah,Célia Bouacha,Céline M'Kadmi,Jérémie Neasta,Catherine Oiryet al. 24th Tetrahedron Symposium, Elsevier, Jun 2024, Montpellier, France Communication dans un congrès hal-04806641v1
La fluorescence au service de la santé : suivi in vitro et in vivo de molécules bioactives impliquées dans la prise alimentaire: Le Récepteur de la Ghréline Sonia Cantel,Séverine Denoyelle,Mario Perello,Jean‐louis Baneres,Jean-Alain Fehrentz UTT de Montpellier, Jan 2024, Montpellier, France Communication dans un congrès hal-04892225v1
Growth hormone secretagogues in Duchenne muscular dystrophy: a preclinical evaluation of potential benefits on muscle function and morphology Paola Mantuano,Brigida Boccanegra,Ornella Cappellari,Santa Cirmi,Elena Brescianiet al. 27th International Hybrid Annual Congress of the World Muscle Society (WMS 2022), World Muscle Society (WMS), Oct 2022, Halifax, NS, Canada. pp.S128 / VP.84, ⟨10.1016/j.nmd.2022.07.358⟩ Communication dans un congrès hal-04837446v1
De la paillasse à la mise sur le marché : une cible pour le traitement de l'obésité: Le récepteur de la Ghréline Sonia Cantel,Séverine Denoyelle,Jean‐louis Baneres,Jean Martínez,Jean-Alain Fehrentz UTT Montpellier, Feb 2022, Montpellier, France Communication dans un congrès hal-04892238v1
Growth hormone secretagogues exert anti-fibrotic actions in duchenne muscular dystrophy: a preclinical study Ornella Cappellari,Paola Mantuano,Brigida Boccanegra,Santa Cirmi,Elena Brescianiet al. 56th Annual Scientific Meeting of the European Society for Clinical Investigation (56th ESCI Annual Scientific Meeting) “Promoting Biomedical Research, Equal Health and Environment in the post-COVID Syndemic Era”, European Society for Clinical Investigation (ESCI), Jun 2022, Bari, Italy. pp.118 / 56ASM-0082 Communication dans un congrès hal-04836119v1
Le récepteur de la Ghréline : une cible majeure pour le développement de ligands à visée thérapeutique Séverine Denoyelle Conférences ED459, Jun 2019, Montpellier, France Communication dans un congrès hal-04833456v1
Ghrelin receptor: design and evaluation of inverse agonists Séverine Denoyelle GDR3545 – GPCR International Meeting, Oct 2019, Montpellier, France Communication dans un congrès hal-04833466v1

Poster de conférence (1)

Interplay between ghrelin and novel analogs of LEAP2, an endogenous ghrelin receptor antagonist: receptor activation and food intake regulation Lucie Holá,Alena Karnošová,Miroslava Blechová,Blanka Železná,Jaroslav Kunešet al. 36th European Peptide Symposium & 12th International Peptide Symposium, Aug 2022, Sitges (Barcelona), Spain. Wiley, Journal of Peptide Science, 28 (S3), pp.P041, 2022 Poster de conférence hal-04834748v1

Brevet (1)

New cationic bolaform hemifluorocarbon vectors, their preparation and applications in gene therapy Ange Polidori,Bernard Pucci,Séverine Denoyelle,Jean Pierre Salles France, Patent n° : FR2883563. 2006 Brevet hal-04121361v1