Stephane Savary Professeur des Universités en Biochimie et Biologie Moléculaire

Identifiants chercheurs

IdHAL :

stephane-savary

ORCID :

0000-0002-9237-1727

IdRef :

071035044

ResearcherID :

http://www.researcherid.com/rid/C-8137-2011

Présentation

Stéphane SAVARY

CSGAUMR6265 CNRS, 1324 INRAE, Institut Agro Dijon, Université Bourgogne EuropeEquipe NeuroFeed9E, boulevard Jeanne d'Arc, 21000 Dijon, Francehttps://csga.fr/

POSITIONS AND EMPLOYMENTSince 2012: Professor of Biochemistry and Molecular Biology, IUT Dijon, University of Bourgogne1998-2012 : Associate Professor, Biochemistry and Molecular Biology, IUT Dijon, University of Bourgogne1996-1998 : Assistant Professor, Molecular Biology, University of Tours, Postdoc in the Research Institute of Insect Biology, Genomic relationship between the wasp Cotesia congregata and its symbiotic polydnavirus.

EDUCATION AND TRAINING2004 - Habilitation to Supervise Researches, Univeristy of Bourgogne, “Cloning and characterization of the ABCD2 gene: therapeutic hope for adrenoleukodystrophy”1996 - PhD. Immunology, University of the Mediterranean Marseille, France, CIML, Identification and characterization of novel ABC transporters in mammals.1993 - MS Immunology, University of the Mediterranean Marseille, France1989-1992 - BS,MS Biochemistry, University of the Mediterranean Marseille, France

THESIS AND MASTER SUPERVISIONSupervisor of 8 PhD studentsSupervisor of 10 Master studentsSupervisor of 2 postdoctoral fellows

RESEARCH RESPONSABILITIES2023 : Director of the Lab. BioperoxIL, EA7270 University of Bourgogne2017-2023: Deputy Director of BioperoxIL2004-2023: Head of the research group “ABCD transporters and X-ALD”, BioperoxIL

PUBLICATIONShttp://www.researcherid.com/rid/C-8137-201152 publications since 1994, average citation per article 35, Average iF 5,1 , h-index 23 (Jan 2025)

OTHER EXPERIENCES AND PROFESSIONAL MEMBERSHIP

President of the BCP 64/65 University Bourgogne Europe

Elected to the Administrative Council of the IUT of Dijon 2018-2022

Member of the concil of the Doctoral School Environment-Health of the University of Bourgogne-Franche-Comté since 2017 (

https://e2s.ubfc.fr/

)

Elected to the Comission of human ressources of the IUT of Dijon 2014-2022

Elected to the Scientific Council of the IUT of Dijon 2006-2012

vice-president of the recruitment committee (section 64 Biochemistry-Molecular Biology) of the University of Bourgogne 2002-2004

President of the AEP-Bio (Association for the Study of Peroxisomes) whose aim is to animate a scientific network and organize scientific meeting every two years on peroxisomal themes.

Co-organizer of the 3rd OEPM (Dijon, 2012), of the 29th Forum of Young Researchers SFBBM (Dijon, 2002) and Organizer of the 11th (Dijon, 2004) and 12th (Paris, 2006) meeting of AEP-Bio

SCIENTIFIC SUMMARYCloning of novel ABC transporters in mammalsABCA1 - Tangier Disease, Cholesterol efflux https://omim.org/entry/600046ABCB7 - Sideroblastic Anemia https://omim.org/entry/300135ABCG1 - Cholesterol efflux https://omim.org/entry/603076ABCD2 - Closest homolog of ABCD1, whose defect is associated with X-linked adrenoleukodystrophy https://omim.org/entry/601081

ABCD2, a therapeutic target for X-ALDTranscriptional regulation of the Abcd2 genePPARalpha pathway, fibrates, fatty acidsDHEA, Thyroid hormone and thyromimetics as inducersPhenyl butyrate and chromatin remodelingLXR antagonists

Structure-function analysis of ABCD2Substrate specificityFunctional redundancyOligomerization

Microglia and physiopathogenesis of X-ALDEstablishment of BV2 microglial mutant cell lines using CRISPR-mediated edition of Abcd1, Abcd2, Acox1 genesBiochemical and functional characterization (lipids, membrane properties, phagocytosis, cytokines, ...)Co-culture with oligodendrocytes or neurons (link between microglial peroxisomes and neurodegeneration)Co-culture with T lymphocytes (link between microglial peroxisomes and immune response)

Peroxisome, lipid sensing and control of food intake (from Jan 2024)

Publications

Article dans une revue (31)

Peroxisomes and the nervous system: progress and challenges in neuroinflammation and cell-specific functions Francesca Di Cara,Stéphane Savary Frontiers in Molecular Neuroscience, 2026, 19, pp.1745086. ⟨10.3389/fnmol.2026.1745086⟩ Article dans une revue hal-05562551v1
Impaired peroxisomal beta-oxidation in microglia triggers oxidative stress and impacts neurons and oligodendrocytes Ali Tawbeh,Catherine Gondcaille,Quentin Raas,Damien Loichot,Yannick Hamonet al. Frontiers in Molecular Neuroscience, 2025, 18, pp.1542938. ⟨10.3389/fnmol.2025.1542938⟩ Article dans une revue (data paper) hal-04958543v1
&lt;i&gt;Ribes nigrum&lt;/i&gt; leaf extract downregulates pro-inflammatory gene expression and regulates redox balance in microglial cells Alvard Minasyan,Vivien Pires,Catherine Gondcaille,Mikayel Ginovyan,Marika Mrózet al. BMC Complementary Medicine and Therapies, 2025, 25 (1), pp.49. ⟨10.1186/s12906-025-04780-7⟩ Article dans une revue hal-04958552v1
Analytical subcellular fractionation of microglial BV-2 cells with peroxisomal beta-oxidation defect Mounia Tahri-Joutey,Isabelle Hamer,Virginie Tevel,Quentin Raas,Catherine Gondcailleet al. Histochemistry and Cell Biology, 2025, 163 (1), pp.44. ⟨10.1007/s00418-025-02372-7⟩ Article dans une revue hal-05097597v1
Microgliosis: a double‐edged sword in the control of food intake Juliette Salvi,Pierre Andreoletti,Etienne Audinat,Eglantine Balland,Selma Ben Fradjet al. FEBS Journal, 2024, 291 (4), pp.615-631. ⟨10.1111/febs.16583⟩ Article dans une revue (article de synthèse) hal-03739689v1
Peroxisome deficiency underlies failures in hepatic immune cell development and antigen presentation in a severe Zellweger disease model Brendon Parsons,Daniel Medina-Luna,Michal Scur,Marinella Pinelli,Gayani Gamageet al. Cell Reports, 2024, 43 (2), pp.113744. ⟨10.1016/j.celrep.2024.113744⟩ Article dans une revue hal-04667779v1
Peroxisomal defects in microglial cells induce a disease-associated microglial signature Quentin Raas,Ali Tawbeh,Mounia Tahri-Joutey,Catherine Gondcaille,Céline Keimeet al. Frontiers in Molecular Neuroscience, 2023, 16 (Sec. Brain Disease Mechanisms), pp.1170313. ⟨10.3389/fnmol.2023.1170313⟩ Article dans une revue hal-04092819v1
Immune response of BV-2 microglial cells is impacted by peroxisomal beta-oxidation Ali Tawbeh,Quentin Raas,Mounia Tahri-Joutey,Céline Keime,Romain Kaiseret al. Frontiers in Molecular Neuroscience, 2023, 16, pp.1299314. ⟨10.3389/fnmol.2023.1299314⟩ Article dans une revue hal-04352894v1
Two Argan Oil Phytosterols, Schottenol and Spinasterol, Attenuate Oxidative Stress and Restore LPS-Dysregulated Peroxisomal Functions in &lt;i&gt;Acox1&lt;sup&gt;−/−&lt;/sup&gt;&lt;/i&gt; and Wild-Type BV-2 Microglial Cells Soukaina Essadek,Catherine Gondcaille,Stéphane Savary,Mohammad Samadi,Joseph Vamecqet al. Antioxidants , 2023, 12 (1), pp.168. ⟨10.3390/antiox12010168⟩ Article dans une revue hal-03994321v1
Protective Effect of Nopal Cactus (Opuntia ficus-indica) Seed Oil against Short-Term Lipopolysaccharides-Induced Inflammation and Peroxisomal Functions Dysregulation in Mouse Brain and Liver Mounia Tahri-Joutey,Fatima-Ezzahra Saih,Riad El Kebbaj,Catherine Gondcaille,Joseph Vamecqet al. International Journal of Molecular Sciences, 2022, 23 (19), pp.11849. ⟨10.3390/ijms231911849⟩ Article dans une revue hal-04342093v1
Peroxisomal ABC Transporters: An Update Ali Tawbeh,Catherine Gondcaille,Doriane Trompier,Stéphane Savary International Journal of Molecular Sciences, 2021, 22 (11), pp.6093. ⟨10.3390/ijms22116093⟩ Article dans une revue (article de synthèse) hal-04344446v1
Do ABC transporters regulate plasma membrane organization? Ambroise Wu,Karolina Wojtowicz,Stéphane Savary,Yannick Hamon,Tomasz Trombik Cellular and Molecular Biology Letters, 2020, 25 (1), ⟨10.1186/s11658-020-00224-x⟩ Article dans une revue hal-02997365v1
A microglial cell model for acyl-CoA oxidase 1 deficiency Q. Raas,F-E Saih,C. Gondcaille,D. Trompier,Y. Hamonet al. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2019, 1864 (4), pp.567-576. ⟨10.1016/j.bbalip.2018.10.005⟩ Article dans une revue hal-02359450v1
Peroxisomes in Immune Response and Inflammation Francesca Di Cara,Pierre Andreoletti,Doriane Trompier,Anne Vejux,Margret H Bülowet al. International Journal of Molecular Sciences, 2019, 20 (16), ⟨10.3390/ijms20163877⟩ Article dans une revue (article de synthèse) hal-04346483v1
CRISPR/Cas9-mediated knockout of Abcd1 and Abcd2 genes in BV-2 cells: novel microglial models for X-linked Adrenoleukodystrophy Q. Raas,C. Gondcaille,Y. Hamon,V. Leoni,C. Cacciaet al. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2019, 1864 (5), pp.704-714. ⟨10.1016/j.bbalip.2019.02.006⟩ Article dans une revue hal-02359446v1
Peroxisomal ATP-binding cassette transporters form mainly tetramers Flore Geillon,Catherine Gondcaille,Quentin Raas,Alexandre M M Dias,Delphine Pecqueuret al. Journal of Biological Chemistry, 2017, 292 (17), pp.6965-6977. ⟨10.1074/jbc.M116.772806⟩ Article dans une revue hal-02329531v1
Brain-derived neurotrophic factor of the cerebral microvasculature: a forgotten and nitric oxide-dependent contributor of brain-derived neurotrophic factor in the brain A. Monnier,Anne Prigent-Tessier,Aurore Quirie,Nathalie Bertrand,Stéphane Savaryet al. Acta Physiologica, 2017, 219 (4), pp.790-802. ⟨10.1111/apha.12743⟩ Article dans une revue hal-01414943v1
Flow Cytometric Analysis of the Expression Pattern of Peroxisomal Proteins, Abcd1, Abcd2, and Abcd3 in BV-2 Murine Microglial Cells. Meryam Debbabi,Thomas Nury,Imen Helali,El Mostafa Karym,Flore Geillonet al. Methods in Molecular Biology, 2017, 1595, pp.257-265. ⟨10.1007/978-1-4939-6937-1_25⟩ Article dans une revue hal-01539021v1
Predictive Structure and Topology of Peroxisomal ATP-Binding Cassette (ABC) Transporters Pierre Andreoletti,Quentin Raas,Catherine Gondcaille,Mustapha Cherkaoui-Malki,Doriane Trompieret al. International Journal of Molecular Sciences, 2017, 18 (7), pp.1593. ⟨10.3390/ijms18071593⟩ Article dans une revue hal-04342713v1
Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158 N murine oligodendrocytes Amira Zarrouk,Thomas Nury,El-Mostafa Karym,Anne Vejux,Randa Sghaieret al. Journal of Steroid Biochemistry and Molecular Biology, 2017, 169, pp.29-38. ⟨10.1016/j.jsbmb.2016.02.024⟩ Article dans une revue istex hal-04342669v1
LXR antagonists induce ABCD2 expression Catherine Gondcaille,Emmanuelle C. Genin,Tatiana E. Lopez,Alexandre M.M. Dias,Flore Geillonet al. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2014, 1841 (2), pp.259-266. ⟨10.1016/j.bbalip.2013.11.003⟩ Article dans une revue hal-01185659v1
Structure-function analysis of peroxisomal ATP-binding cassette transporters using chimeric dimers Flore Geillon,Catherine Gondcaille,Soëli Charbonnier,Carlo W. van Roermund,Tatiana E. Lopezet al. Journal of Biological Chemistry, 2014, 289 (35), pp.24511-24520. ⟨10.1074/jbc.M114.575506⟩ Article dans une revue hal-01223550v1
Brain Peroxisomes Doriane Trompier,A. Vejux,A. Zarrouk,Catherine Gondcaille,Flore Geillonet al. Biochimie, 2013, 98, pp.102-110. ⟨10.1016/j.biochi.2013.09.009⟩ Article dans une revue hal-01185043v1
Peroxisomal ABC transporters and X-linked adrenoleukodystrophy Flore Geillon,Doriane Trompier,Catherine Gondcaille,Gérard Lizard,Stéphane Savary Médecine/Sciences, 2012, 28 (12), pp.1087-1094. ⟨10.1051/medsci/20122812019⟩ Article dans une revue hal-01221377v1
Substrate specificity overlap and interaction between Adrenoleukodystrophy protein (ALDP/ABCD1) and Adrenoleukodystrophy-related protein (ALDRP/ABCD2) Emmanuelle C. Genin,Flore Geillon,Catherine Condcaille,Anne Athias,Philippe Gambertet al. Journal of Biological Chemistry, 2011, 286 (10), pp.8075-8084. ⟨10.1074/jbc.M110.211912⟩ Article dans une revue hal-01221369v1
Peroxisomal and mitochondrial status of two murine oligodendrocytic cell lines (158N, 158JP): potential models for the study of peroxisomal disorders associated with dysmyelination processes. Mauhamad Baarine,Kevin Ragot,Emmanuelle C. Genin,Hammam El Hajj,Doriane Trompieret al. Journal of Neurochemistry, 2009, 111 (1), pp.119-31. ⟨10.1111/j.1471-4159.2009.06311.x⟩ Article dans une revue hal-00514890v1
Exon organisation of the mouse gene encoding the Adrenoleukodystrophy related protein (ALDRP) Cyril Broccardo,Nathalie Troffer-Charlier,Stephane Savary,Jean-Louis Mandel,Giovanna Chimini European Journal of Human Genetics, 1998, 6, pp.638-641. ⟨10.1038/sj.ejhg.5200233⟩ Article dans une revue hal-04022404v1
Chromosomal localization of the adrenoleukodystrophy-related gene in man and mice Stéphane Savary,Nathalie Troffer-Charlier,Gabor Gyapay,Marie-Geneviève Mattei,Giovanna Chimini European Journal of Human Genetics, 1997, 5 (2), pp.99-101 Article dans une revue hal-03832784v1
A close relative of the adrenoleukodystrophy (ALD) gene codes for a peroxisomal protein with a specific expression pattern. Gaël Lombard-Platet,Stéphane Savary,Claude-Olivier Sarde,Jean-Louis Mandel,Giovanna Chimini Proceedings of the National Academy of Sciences of the United States of America, 1996, 93 (3), pp.1265-1269. ⟨10.1073/pnas.93.3.1265⟩ Article dans une revue hal-04993641v1
Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene S. Savary,F. Denizot,M. -F. Luciani,M. -G. Mattei,G. Chimini Mammalian Genome, 1996, 7 (9), pp.673-676. ⟨10.1007/s003359900203⟩ Article dans une revue istex hal-04342137v1
Cloning of Two Novel ABC Transporters Mapping on Human Chromosome 9 Marie Françoise Luciani,François Denizot,Stéphane Savary,Marie Geneviève Mattei,Giovanna Chimini Genomics, 1994, 21 (1), pp.150-159. ⟨10.1006/geno.1994.1237⟩ Article dans une revue istex hal-04342121v1

Communication dans un congrès (1)

Lessons from impaired peroxisomal function in microglia: implications for neuroinflammation and neuronal health Ali Tawbeh,Catherine Gondcaille,Quentin Raas,Mounia Tahri Joutey,Fatima-Ezzahra Saihet al. EMBO Workshop "Celebrating 70 years of peroxisome research", Sep 2025, Sant Feliu De Guixols, Spain Communication dans un congrès hal-05411753v1

Ouvrages (1)

X-linked Adrenoleukodystrophy Doriane Trompier,Stéphane Savary Morgan & Claypool Publishers, 2 (1), pp.1-134, 2013, Genetic Basis of Disease, Michael Dean, 9781615045549 Ouvrages hal-04345336v1